Misplaced Pages

#57942

40-454: Funding for construction of the initial $ 70 million facility came primarily from the state of Florida's cigarette tax, while the momentum to create the center came from a cadre of legislators, physicians, educators, and business leaders who envisioned a new dimension of cancer care and research in Florida. In late 1978, H. Lee Moffitt , a Florida state representative , recognized the need for

80-421: A Chimeric Antigen Receptor (CAR) T cell therapy, also known as CAR-T. Moffitt Cancer Center's Frederick Locke, is the co-lead investigator of the pivotal ZUMA-1 clinical trial that tested the new therapy, which is manufactured by Kite, a Gilead company. In February 2024, the U.S. Food and Drug Administration approved a first-of-its-kind immunotherapy pioneered at Moffitt for patients with advanced melanoma. Moffitt

120-576: A comprehensive cancer center within the state after several friends died from cancer. An excellent negotiator, Moffitt put his plan into motion by first proposing the idea to Hollis Boren, then dean of the University of South Florida College of Medicine. Over lunch at the Tampa Club, Moffitt proposed his idea. By dessert, Boren has signed on. "Out of that discussion came plans for a plug-shaped, multilevel cancer research teaching hospital to be built

160-546: A large percentage of melanoma patients with a specific gene mutation. Approved by the FDA in January 2014, Mekinist in combination with Tafinlar is one of the biggest advancements in melanoma treatment in the past 30 years. In August 2011, the U.S. Food and Drug Administration (FDA) approved the drug vemurafenib (Zelboraf) for metastatic melanoma patients who test positive for a specific gene mutation. Moffitt Cancer Center conducted

200-576: A new 50,000-square-foot satellite facility at International Plaza. The building replaced Moffitt's former outpatient center at Tampa General Hospital. In July 2012, William Dalton, became the CEO of M2Gen and Moffitt's new Personalized Medicine Institute. Alan List, who previously served as Moffitt's executive vice president/physician-in-chief and president of the Moffitt Medical Group, succeeded Dalton as CEO and president. Thomas Sellers assumed

240-566: A new cancer immunotherapy for melanoma patients called Keytruda became the first anti-PD-1 (programmed death receptor-1) therapy approved in the United States. Jeffrey Weber, director of the Donald A. Adam Comprehensive Melanoma Research Center of Excellence at Moffitt, was one of the lead investigators of the clinical trial which led to the drug receiving breakthrough status from the FDA. In January 2016, researchers at Moffitt teamed up with

280-517: A new legislative session. The Florida Legislature meets in a 60-day regular legislative session each year. Regular legislative sessions in odd-numbered years must begin on the first Tuesday after the first Monday in March. Under the state Constitution, the Legislature can begin even-numbered year regular legislative sessions at a time of its choosing. Special legislative sessions may be called by

320-525: A range of techniques to validate the role of the novel candidate genes in the development of cancer. The ultimate aim is to translate these findings into improved treatment options for cancer patients. There are many different genes being researched for possible cancer therapies. Among the most studied are the p53 gene and the PTEN gene . These genes are major regulators of the cell cycle and other pathways involved in cellular and genomic integrity. By halting

360-670: A registration trial using the drug manufactured by Genentech, a member of the Roche Group. Anna Giuliano, director of Moffitt's Center for Infection Research in Cancer, led two studies on human papillomavirus (HPV) infection in men. Her work strengthened the Food & Drug Administration (FDA) recommendation for boys and men to receive HPV vaccinations and provided useful data for the development of realistic cost-effectiveness models for male HPV vaccination internationally. In September 2014,

400-408: A regularly used form of immune gene therapy. CAR-T involves manipulation of a patient's natural T cells to express a chimeric antigen receptor. This receptor, now on millions of the patient's T cells, recognizes cancerous cells that express specific antigens . Usually, the T cell antigen receptor is inactive but when the receptor recognizes a certain cancerous antigen, the physical structure of

440-640: A robust anti-tumor immune response, spearheaded by the CAR-T cells. There are various known inhibitory receptors on the CAR-T cell; through manipulation of these receptors and the molecules that bind them, expression of the CAR-T cell can be amplified. CAR-T cells can also be combined with cytokines to improve the efficacy of the immunotherapy method. Cytokines are messenger molecules that can act on themselves, nearby cells, or distant cells. The signal pathways of these cytokines can be used to enhance CAR-T anti-tumor characteristics. For example, Interleukin 2 (IL2)

SECTION 10

#1732798582058

480-559: A short walk away from the USF clinics," The Tampa Times reported on February 5, 1979. Moffitt and Boren had gathered information about the need for a comprehensive cancer center, the article said, and the need was great. Moffitt sought community support and convinced the State Legislature to fund the facility. During the center's planning phase, consultants associated with NCI-designated Cancer Centers were retained to ensure that

520-491: A supermajority in the State House with 85 seats; Democrats are in the minority with 35 seats. In 1995, the U.S. Supreme Court ruled that states could not enact congressional term limits. Florida legislators must be at least twenty-one years old, an elector and resident of their district, and must have resided in Florida for at least two years prior to election. Each year during which the Legislature meets constitutes

560-404: A tumor immunologist with 33 years of oncology experience, its new president and CEO. Through clinical trials, Jeffrey Weber, director of the Donald A. Adam Comprehensive Melanoma Research Center at Moffitt, and researchers at Moffitt Cancer Center discovered two monotherapy drugs – Mekinist (trametinib) and Tafinlar (dabrafenib) – can be safely combined to overcome or delay treatment resistance for

600-477: Is a 28,000-square-foot outpatient facility bringing access to Moffitt expertise and nationally-ranked cancer care to Pasco County. Moffitt McKinley Hospital, 10901 N. McKinley Drive, Tampa, FL, is an inpatient surgical hospital located on Moffitt's McKinley Campus. The 10-story, 500,000-square-foot facility provides patients with the latest innovations in surgical techniques and inpatient care. Moffitt Cancer Center at Port Tampa Bay, 651 Channelside Drive, Tampa, FL,

640-536: Is a community outreach and education center near downtown Tampa. Former campuses: Future teams: Discontinued teams: Florida House of Representatives Minority The Florida House of Representatives is the lower house of the Florida Legislature , the state legislature of the U.S. state of Florida , the Florida Senate being the upper house . Article III, Section 1 of

680-412: Is a cytokine that acts as a growth factor for various immune system cells, including T cells. In regards to gene therapy, IL2 can be used to increase replication and dispersing of CAR-T cells throughout the body. There is room for improvement with this gene therapy approach. Firstly, the antigens of interest expressed on the cancer cells may sometimes be expressed on regular body cells, too. This means

720-752: Is a targeted approach to cancer therapy where actual immune cells of the patient and their genes are manipulated to produce an anti-tumor response. The body's own immune system is used to attack the tumor cells, therefore the immune system can naturally attack the specific cancer cells again to in the future if necessary. Many types of immunotherapies exist including bone marrow transplants, antibody therapies, and various manipulations of host immune cells to target and kill cancer cells. Cellular receptors , antigens, and cofactor molecules are some such cellular manipulations to target cancer cells. Chimeric antigen receptor T cell immunotherapy (CAR-T), possibly combined with cytokines and checkpoint inhibitors , are

760-723: Is an interdisciplinary medical specialty at the interface of medicinal chemistry and oncology that refers to the investigation of the chemistry of cancer and tumors at the molecular scale. Also the development and application of molecularly targeted therapies . Molecular oncology has identified genes that are involved in the development of cancer. The research combined diverse techniques ranging from genomics , computational biology , tumour imaging , in vitro and in vivo functional models to study biological and clinical phenotypes . The proteins produced by these genes may serve as targets for novel chemotherapy drugs and other cancer treatments, or imaging scans. Scientists use

800-512: The Constitution of Florida , adopted in 1968, defines the role of the Legislature and how it is to be constituted. The House is composed of 120 members, each elected from a single-member district with a population of approximately 180,000 residents. Legislative districts are drawn on the basis of population figures, provided by the federal decennial census. Representatives' terms begin immediately upon their election. The Republicans hold

840-727: The University of Florida and Shands at UF formed a partnership with Moffitt to develop programs in cancer care, research and prevention. In 2009, the University of South Florida and Moffitt were awarded $ 6 million in federal grant money to create the Center for Equal Health , a five-year partnership focused on addressing issues of cancer health disparities . Scientific programs include molecular oncology ;, drug discovery ; immunology ; experimental therapeutics ; computational biology of cancer; health outcomes; and behavior and risk assessment, detection and intervention. It also serves as

SECTION 20

#1732798582058

880-795: The Florida House of Representatives. Following sizable GOP gains in the 1994 election, which significantly reduced the Democratic Party majority in the Florida House, Republicans captured a majority in the 1996 election. The Republican Party has been the majority party since that time in the House. Additional information on the past composition of the Florida House of Representatives can be found in Allen Morris's The Florida Handbook (various years, published every two years for many years). Molecular Oncology Molecular oncology

920-546: The Florida Legislature approved more than $ 706 million for a new H. Lee Moffitt Cancer Center and Research Institute campus in Pasco County. $ 600 million in state funding will be distributed in yearly in $ 20 million yearly increments for each of the next 30 years. On June 10, 1998, in a ceremonial signing at Moffitt, Florida governor Lawton Chiles approved a legislative initiative to fund construction of

960-604: The Moffitt Research Center. Moffitt at International Plaza is a 50,000-square-foot full service outpatient facility near Tampa International Airport . The facility includes physician office visits, infusion services, radiation and radiology. Moffitt Cancer Center Prevention Research, Fowler Campus, located in north Tampa, is a facility that practices research for prevention and early detection of cancer. The Richard M. Schulze Family Foundation Outpatient Center at McKinley Campus, 10920 N. McKinley Drive, includes

1000-724: The Moffitt Tower Project, which opened in April 2003, adding more than 350,000 square feet (33,000 m) of new space. This expansion includes the Vincent A. Stabile Research Building, eponymously named in recognition of the largest private donation ever made to the Cancer Center. The new construction also includes an expansion of the Moffitt Clinic. In addition to new research laboratories, which nearly double

1040-399: The T cell changes to destroy the cancer cell. This is a method of cancer treatment that works on the cellular and molecular level. Some regulatory proteins , specifically immune checkpoint inhibitors , have been found to reduce the ability of T cells to multiply within the body. In order to optimize the efficacy of CAR-T gene therapy, these checkpoint inhibitors can be blocked to stimulate

1080-469: The acquisition of the Research Center building across from the Cancer Center enhanced the recruitment of scientists, clinicians, and support staff, and expanded Moffitt's vision beyond the original structure. The Moffitt Research Center became the focal point for basic and translational cancer research, with the overriding goal to produce discoveries that could be translated quickly from the bench to

1120-457: The body's T cells will attack its own healthy cells instead of the cancer cells when the antigen is lacking specificity with just the cancer cell. A possible solution to this problem is to include two different antigen receptors on the CAR-T cells to make them even more specific. The second issue with the CAR-T immunotherapy approach is that it can cause cytokine release syndrome . This is when an excess of pro-inflammatory factors are released by

1160-404: The breast and skin cancer clinics, infusion center, research labs and four surgery suites. Moffitt Malignant Hematology & Cellular Therapy at Memorial Healthcare System, 801 N. Flamingo Road, Pembroke Pines, FL, provides a comprehensive Blood and Marrow Transplant Cellular Therapy Program for South Florida residents. Moffitt Cancer Center at Wesley Chapel, 2590 Healing Way, Wesley Chapel, FL,

1200-678: The cancer center's research capabilities, the new facilities include a digital imaging center, and a new infusion center. In 1991, John Ruckdeschel , assumed the position of center director, president and CEO. Under Ruckdeschel's leadership, Moffitt became a National Cancer Institute (NCI) Comprehensive Cancer Center . In 2017, the NCI renewed Moffitt's Cancer Center Support Grant for another five years. Currently, Moffitt receives more than $ 50 million annually in peer-reviewed grant monies. In 2002, Ruckdeschel stepped down, and William Dalton, became Moffitt's third president, CEO and center director. In 2008,

1240-596: The cell cycle, these genes ensure that genetically damaged cells are not passing on that damage to daughter cells. The cell cycle may be paused and if the damage is severe enough, the p53 and PTEN gene pathways may signal for the death of the damaged cells. Both the p53 and PTEN genes are classified as tumor suppressors because their pathways oversee the repair of cells that may replicate out of control with damaged genetic material, eventually leading to cancer growth if not kept in check. Mutations in these genes are seen in more than half of human cancers. Immune gene therapy

H. Lee Moffitt Cancer Center & Research Institute - Misplaced Pages Continue

1280-454: The finished facility would be as technologically advanced and as efficiently designed as possible. Groundbreaking ceremonies took place in January 1983. The center was incorporated in the spring of 1984 and was named for Houston Lee Moffitt, then Speaker of the State House of Representatives. The building was dedicated in October 1986 and admitted its first patients that same month. In 1990,

1320-456: The governor, by a joint proclamation of the Senate president and House speaker, or by a three-fifths vote of all legislators. During any special session the Legislature may only address legislative business that is within the purview of the purpose or purposes stated in the special session proclamation. *Elected in a special election. From 1874 to 1996, the Democratic Party held majorities in

1360-426: The immune system and can cause unpleasant side effects for the patient like nausea and a high fever . In the past few decades, gene therapy has emerged as a targeted way to treat cancer. Gene therapy introduces foreign genetic sequences to diseased cells in order to change the expression of these cancerous cells that are functioning with severely damaged genomes. Cancer cells do not behave like normal cells, so

1400-418: The patient's bedside. The Florida Legislature allocated $ 12 million for renovation and equipment for this 100,000-square-foot (9,300 m) structure, and the Moffitt Research Center became fully operational in 1995. In 1999, 48,000 square feet (4,500 m) of basic research lab space was added to the Moffitt Research Center at a cost of $ 11 million to house the growing need for additional scientists. In 2022

1440-490: The role of center director. In February 2013, Moffitt began construction of a $ 74.2 million outpatient facility on the cancer center's 30-acre property on N McKinley Drive, about a mile from Moffitt's main campus. In November 2015, Moffitt opens the McKinley Outpatient Center. The six-story, 207,000-square-foot facility at 10920 N McKinley Drive is located about a mile from the main campus. Services on

1480-575: The site for the Bill and Beverly Young National Functional Genomics Center, funded by the U.S. Department of Defense . Moffitt Cancer Center is affiliated with the University of South Florida Morsani College of Medicine and provides education to medical students and residency training as well. On June 24, 2011, Moffitt Cancer Center opened the first blood and marrow transplant (BMT) clinic in Puerto Rico. On July 1, 2011, Moffitt Cancer Center opened

1520-546: The site include the skin and breast cancer clinics, four operating rooms, an imaging suite, research labs, space for blood draws and a Publix pharmacy. In July 2017, Moffitt and Memorial Healthcare announce a partnership to establish a comprehensive blood and marrow transplant cellular therapy program for South Florida residents. The alliance brings the renowned cancer center's access to research, clinical trials, and comprehensive treatment to leukemia, lymphoma and multiple myeloma patients. In August 2020, Moffitt named Patrick Hwu,

1560-452: The state of Florida in a study to see if making fruits and vegetables available to children who otherwise may not have them readily available can decrease their risk of cancer. In October 2017, the Food and Drug Administration announced the approval of Yescarta™, a revolutionary new immunotherapy for adult patients with diffuse large B cell lymphoma, a form of non-Hodgkin's lymphoma. Yescarta is

1600-487: Was a driving force in getting lifileucel (Amtagvi) FDA-approved for the treatment of adult patients with unresectable or metastatic melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor with or without a MEK inhibitor. Moffit Cancer Center is located on the campus of the University of South Florida in north Tampa. The center includes the hospital, Muriel Rothman Building (clinic), Vincent A. Stabile Research Building and

#57942