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48-558: In 2003, David Gobel , Aubrey de Grey , and Dane Gobel rebranded the organization Methuselah Foundation, named after Methuselah , the grandfather of Noah in the Hebrew Bible , whose lifespan was recorded as 969 years. The new name was introduced at the 32nd Annual Meeting of the American Aging Association , where they awarded the first Methuselah Mouse Prize to Andrej Bartke for his work on mice that lived

96-579: A $ 7 trillion marketplace. All of the Foundation's grants, investments, prizes and policy decisions follow seven strategies: The Methuselah Funds (M Fund) was created in 2017 as an LLC subsidiary of the Methuselah Foundation to incubate and invest in early-stage companies. The entity operates as the mechanism through which the Foundation turns its vision into reality by identifying young companies whose research promises to transform

144-621: A Master of Medical Science (MMSc) degree through the Yale Physician Associate Program and Yale Physician Assistant Online Program for prospective physician assistants . Public health degrees are administered through the Yale School of Public Health . There are also joint degree programs with other disciplines at Yale, including the MD/ Juris Doctor (J.D.) in conjunction with Yale Law School ;

192-479: A broadband network that allowed sick kids at thousands of homes and over 110 children's hospitals to "go out and play" in a rich virtual world where they can communicate with friends and family. He is also co-inventor of World's, Inc., one of the internet’s earliest shared 3D virtual worlds using avatar-based communication. As co-founder and vice president of Knowledge Adventure, Inc. (1991–1994), Gobel invented "mouse movies" (now known as non-linear video) in which

240-504: A co-founder of ethereum and transhumanist, made a series of donations to the foundation. The three transfers, made minutes apart, contained 432 trillion Dogelon Mars , worth about $ 336 million at the time of transfer, and two transfers of 1000 Ether in total, worth more than $ 2 million. David Gobel David Gobel (born 1952 in Baltimore , Maryland ) is an American philanthropist , entrepreneur , inventor , and futurist . He

288-860: A controlled laboratory environment." In November 2016, in conjunction with the Vascular Tissue Challenge, the New Organ Alliance hosted at the NASA Research Park the Vascular Tissue Challenge Roadmapping Workshop, with funding from the NSF . In 2013, Methuselah began fiscally sponsoring and collaborating with the Organ Preservation Alliance, an initiative coordinating research and stakeholders for

336-578: A controlled laboratory environment." Two teams were awarded prizes for their breakthrough work in 2021. In November 2016, in conjunction with the Vascular Tissue Challenge, the New Organ Alliance hosted at the NASA Research Park the Vascular Tissue Challenge Roadmapping Workshop, with funding from the NSF. In 2021, Methuselah announced that a second collaboration with NASA , the Deep Space Food Challenge, awarded $ 25,000 prizes to each of

384-532: A former administrator pled guilty to fraud and tax charges for the theft of over $ 40 million dollars of computer and electronic software. Jamie Petrone-Codrington illegally bought and sold hardware purchased for the School of Medicine, starting in 2013. According to the court records, Petrone-Codrington was turned in by an anonymous tip after being seen loading computer equipment into her private vehicle, and after ordering high volumes of equipment. Before 1845, there

432-570: A minimum of $ 1,000 annually, toward the organization. The initiative was named after the 300 Spartans who held the pass at Thermopylae in 480 BC during the Greco-Persian War . In addition, in 2015, the foundation began memorializing The 300 donors with a monument at St. Thomas Island in the U.S. Virgin Islands . On September 16, 2006, Peter Thiel , co-founder and former CEO of the online payments system PayPal , announced that he

480-892: A student fails, it is his or her responsibility to meet with a professor and arrange for an alternative assessment - passing grades are not released), clinical clerkship evaluations, and the United States Medical Licensing Examination (USMLE). Prior to graduation , students are required to submit a thesis based on original research . For 2024, U.S. News & World Report ranked Yale School of Medicine tied at #10 in Best Medical Schools: Research and tied at #108 in Best Medical Schools: Primary Care. In 18th century United States, credentials were not needed to practice medicine. Prior to

528-512: A tobacco-farming community where his parents came from, and where he practiced as a country physician for the rest of his life. The saddlebags that Dr. Bissell carried in his practice, packed with paper packets and glass bottles, are today in the school's Medical Historical Library. The original building (at Grove and Prospect) later became Sheffield Hall, part of the Sheffield Scientific School (razed in 1931). In 1860,

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576-515: A tuition-free fifth year of research are eligible for the Master of Health Science degree. The school employs the "Yale System" established by Dean Winternitz in the 1920s, wherein first- and second-year students are not graded or ranked among their classmates. In addition, course examinations are anonymous and are intended only for students' self-evaluation. Student performance is thus based on seminar participation, qualifying examinations (if

624-405: A variety of companies developing breakthrough technologies and clinical interventions in regenerative medicine. These companies include: Under Gobel, Methuselah has sponsored several competitions to encourage scientific innovation that can benefit longevity: In addition, Gobel has overseen Methuselah's investment in and support of organizations whose mission has been to promote an environment that

672-465: A venture project to design and build the world’s first fully independent artificial intelligence robotic online professional stock trading system. He also developed VastMind, a cloud-enabled parallel processing grid computing application to utilize wasted CPU cycles in broadband and LAN connected computers. He co-founded Starbright in 1995, partnering with Steven Spielberg , Intel , Sprint , and Tandem Computers to design and create Starbright World ,

720-691: Is co-founder and CEO of the Methuselah Foundation , CEO of the Methuselah Fund , and one of the first to publicly advance the idea of longevity escape velocity , even before this term was formulated. David Gobel heads the Methuselah Foundation, a medical charity that was organized in 2000 and is based in Springfield , VA. Under Gobel's leadership, Methuselah has invested millions of dollars to support research and development in regenerative medicine, regenerative medicine , and

768-941: Is actively involved in efforts to change how the public thinks about extending the healthy human lifespan. With co-founders Dane Gobel and Aubrey de Grey , Gobel established Methuselah in order to, as stated on its original website, "shed light on the processes of aging and find ways to extend healthy life." The organization works in a variety of ways: Incubating companies that are developing breakthrough technologies, supporting mission-relevant ventures that promote longevity research, funding such research directly and supporting projects and prizes to accelerate breakthroughs in longevity. Through Methuselah, Gobel, and de Grey established research programs focused on advanced human bioremedial biology at Rice University and Arizona State University —the world's first use of environmental remediation techniques to be directed at reversing "pollution" in human cells. Gobel also oversaw Methuselah's funding of

816-483: Is known for its historical collections. The faculty includes 70 National Academy of Sciences members, 47 National Academy of Medicine members, and 13 Howard Hughes Medical Institute investigators. For the class of 2022, the school received 4,968 applications to fill 104 seats. The median GPA for the class was 3.89, and the median MCAT was 521. The School of Medicine offers the Doctor of Medicine (MD) degree and

864-472: Is supportive of life extension, including: Gobel was instrumental in the 2007 creation of a new rejuvenation research program called " Strategies for engineered negligible senescence " (SENS), to help identify, repair and remove cell-level damage before it causes systemic harm. Though Methuselah continues to provide support for years, SENS spun out as the independent SENS Research Foundation in 2009, and continues its work to use regenerative medicine to repair

912-642: Is the medical school at Yale University , a private research university in New Haven, Connecticut . It was founded in 1810 as the Medical Institution of Yale College and formally opened in 1813. The primary teaching hospital for the school is Yale New Haven Hospital . The school is home to the Harvey Cushing/John Hay Whitney Medical Library , one of the largest modern medical libraries which

960-483: The Albert Einstein College of Medicine to fund development. Aging is a leading risk factor for most common neurodegenerative diseases, including strokes, brain tumors, aneurysms, cognitive impairments and dementias. In 2013, Methuselah Foundation began a partnership with Organovo to fund the use of their 3D bioprinters at academic research centers for biomedical research. Under the grant program,

1008-543: The National Institute on Aging's Interventions Testing Program. In 2015, with funding from the Methuselah Foundation and Life Extension Foundation , the bowhead whale genome was sequenced by João Pedro de Magalhães and his team at the University of Liverpool . The bowhead whale is possibly the longest-lived mammal, capable of living over 200 years. The genome project was undertaken to learn more about

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1056-521: The University of California, Riverside . Additionally, in 2009, the first Mprize Lifespan Achievement Award went to Z. Dave Sharp of the University of Texas Health Science Center at San Antonio for extending the lifespan of already aged mice using the pharmaceutical rapamycin . In May 2014, at the 43rd Annual Meeting of the American Aging Association, Methuselah Foundation awarded a $ 10,000 Mprize to Huber Warner for his founding of

1104-712: The VOXER iPhone app and the world's first hand-held mass spectrometer (aka ' Tricorder ') He also conceived and co-designed the IdeaFactory , DHS’s innovation management system. Using "wisdom of crowds" principles and bottom-up techniques to bring the experience and intelligence of 170,000 employees to bear on critical problems of security, efficiency and public service, IdeaFactory is featured on whitehouse.gov as an example of government innovation. During his tenure at TSA, Gobel helped design and develop numerous other programs, including TSA’s Red Cell counter-terrorism group,

1152-772: The 18 U.S. teams that designed a novel food production technology concept that maximizes safe, nutritious and palatable food outputs for long-duration space missions. The competition has entered a second round, in which teams must actually build their technology. The Alliance for Longevity Initiatives, whose mission is to create social and political action around the issue of combating age-related chronic conditions and increasing our number of healthy, disease-free years. The organization seeks to build policies that encourage economic and scientific support for more longevity solutions, such as bioengineered patient trials and dramatically improved biomedical research models that use engineered human tissue. Methuselah Foundation contributed $ 1 million to

1200-612: The 2015 sequencing of the longest-lived mammal, the bowhead whale, which can live more than 200 years. The objective of this work was to identify any protective molecular adaptations within the species that may be relevant to age-related diseases, particularly cancer. In 2021, Methuselah contributed $ 1 million to Albert Einstein College of Medicine to fund the development of engineered replacement brain structures to correct age-related neurological damage without losing memories or self identity. Gobel has directed Methuselah's investment in

1248-628: The Arena XXI transportation security system, the Virtual Continuity of Operations conops, and TSA’s Information Technology Management Council. Gobel is co-founder of the Supercentenarian Research Foundation. He developed corporate and technology strategy at Eyegaze, a company that develops an advance eye-driven communication device. From 1996 to 2002, Gobel was president of Obvious Software LLC,

1296-472: The M Fund aims to maximize the business success of a portfolio company inline with strategic liquidity events. However, unlike those organizations, it is primarily focused on maximizing what it calls "return on mission", which it defines as extending the healthy human lifespan. As such, the M Fund strives to support real-world products and therapies that can help any patient come to market. Gobel and Ruiz have led investments in: In 2016, NASA in partnership with

1344-534: The MD/ Master of Business Administration (MBA) in conjunction with the Yale School of Management ; the MD/ Master of Public Health (MPH) in conjunction with the Yale School of Public Health ; science or engineering in conjunction with the Yale Graduate School of Arts and Sciences (MD/ PhD ); and the MD/ Master of Divinity (MDiv) in conjunction with Yale Divinity School . Students pursuing

1392-408: The New Organ Alliance announced the Vascular Tissue Challenge. Creating a sufficient blood vessel system – vasculature – is often seen by biomedical researchers as a primary impediment in engineering thick tissues. The Vascular Tissue Challenge offers a $ 500,000 prize "to be divided among the first three teams that successfully create thick, metabolically-functional human vascularized organ tissue in

1440-408: The New Organ Alliance announced the Vascular Tissue Challenge. Creating a sufficient blood vessel system – vasculature – is often seen by biomedical researchers as a primary impediment in engineering thick tissues. The Vascular Tissue Challenge offers a $ 500,000 prize "to be divided among the first three teams that successfully create thick, metabolically-functional human vascularized organ tissue in

1488-573: The New Organ Liver Prize, a $ 1,000,000 award to the first team that can create a bioengineered or regenerative liver therapy for a "large mammal, enabling the host to recover in the absence of native liver function and survive three months with a normal lifestyle." The initiative is held in partnership with the Organ Preservation Alliance. New Organ Alliance worked out a technology roadmap report for organ banking and bioengineering solutions to help address organ shortages. The roadmap

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1536-568: The backbone organization for the strategies for engineered negligible senescence (SENS) program, a long-term research framework developed by Aubrey de Grey. The SENS program aims to prevent or reverse seven forms of molecular or cellular damage associated with aging. During that time, de Grey and David Gobel established SENS-related research programs on human bioremedial biology – "getting the crud out" in Methuselah's parlance – at Rice University and Arizona State University . The programs were

1584-463: The close relationship between the Methuselah Foundation and SENS Research Foundation and their common activities, there are sometimes misunderstandings about their budgets, directions, and amounts of donations which can be distributed between these organizations for various purposes. In 2004, the Methuselah Foundation began a donor initiative called "The Methuselah 300" ("The 300"), a community of philanthropic donors pledging $ 25,000 over 25 years, at

1632-559: The damage underlying the diseases of aging. As Chief Venture Strategist in the Office of Security Operations at TSA from 2002 to 2013, Gobel proposed, designed, and operated the Department of Homeland Security 's first venture capital arm, which was focused on nurturing companies and technologies to modernize and automate security for the country. He was responsible for multiple investments in cutting-edge security capabilities, including

1680-413: The equivalent of 180 human years. The Foundation's work includes: Throughout its history, the Foundation has helped to reshape the perception of longevity research with the public and the scientific community. When it was launched, the field of longevity science was largely thought to be a playground for eccentrics. Today, anti-aging or longevity research exists in the scientific mainstream and represents

1728-549: The first faculty members. Silliman was a professor of chemistry and taught at both Yale College and the Medical School. The other two founding faculty were Jonathan Knight , anatomy, physiology and surgery and Eli Ives , pediatrics. One of Yale's earliest medical graduates was Dr. Asaph Leavitt Bissell of Hanover, New Hampshire , who graduated in 1815, a member of the school's second graduating class. Following his graduation, Dr. Bissell moved to Suffield, Connecticut ,

1776-479: The first use of environmental remediation principles directed at reversing "pollution" in human cells. Additionally, Methuselah sponsored a series of SENS-focused roundtables and conferences , and funded the writing of Ending Aging , co-authored by de Grey and Michael Rae. Under de Grey's continued leadership, SENS spun out from Methuselah as the SENS Research Foundation in 2009. Due to

1824-489: The foundation committed "at least $ 500,000 in direct funding for research projects across several institutions." The first recipients were Yale School of Medicine , UCSF School of Medicine , and the Murdoch Children's Research Institute . The Methuselah Mouse Prize (Mprize) was created to increase scientific and public interest in longevity research by awarding two cash prizes: "one to the research team that broke

1872-545: The founding of the medical school, Yale graduates would train through an apprenticeship in order to become physicians. Yale President Ezra Stiles conceived the idea of training physicians at Yale and ultimately, his successor Timothy Dwight IV helped found the medical school. The school was chartered in 1810 and opened in New Haven in 1813. Nathan Smith (medicine and surgery) and Benjamin Silliman (pharmacology) were

1920-536: The human lifespan, providing them with seed funds to underwrite their work and supporting them with ongoing business counsel. In this way, M Fund operates much like a business incubator to help young startups focus and build, and a business accelerator to help more mature organizations develop or acquire the resources needed to sustain their growth. Strategic counsel is typically provided by Foundation Founder and M Fund CEO David Gobel and M Fund Co-Founder and Managing Director Sergio Ruiz. Like traditional venture funds,

1968-415: The mammal's mechanisms for longevity and resistance to age-related diseases, which are unknown. An assembly of the bowhead whale genome has been made available online to promote further research. The Methuselah Foundation fiscally sponsors the New Organ Alliance, an initiative aimed at raising awareness and facilitating research to help alleviate organ donation shortages. In 2013, the foundation announced

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2016-408: The movement of the user's mouse would link non-linearly to a database of video frames. At Knowledge Adventure, Gobel produced and directed 6 best-selling multimedia titles, including "3D Body Adventure," "Buzz Aldrin's Space Adventure," "Science Adventure," "America Adventure," " Bug Adventure ," and "The Discoverers" by Daniel J. Boorstin. Yale School of Medicine The Yale School of Medicine

2064-516: The preservation of tissues and organs. The organization's activities have included: The Organ Preservation Alliance, an initiative coordinating research and stakeholders focused on the preservation of tissues and organs. In 2015, OPA became an independent Tax exempt non-profit organization. In 2006, Methuselah contributed capital and fiscal sponsorship to launch the Supercentenarian Research Foundation (SRF). SRF

2112-623: The school moved to Medical Hall on York Street, near Chapel (this building was razed in 1957). In 1925, the school moved to its current campus, neighboring the hospital. This campus includes the Sterling Hall of Medicine (erected in 1925), Boyer Center for Molecular Medicine (1991, designed by Cesar Pelli ), Anlyan Center (2003, designed by Payette and Venturi Scott Brown ) and the Amistad Building (2007, designed by Herbert Newman). On March 28, 2022, Jamie Petrone-Codrington,

2160-423: The world record for the oldest-ever mouse; and one to the team that developed the most successful late-onset rejuvenation strategy ." The Mprize was announced publicly in 2003 by David Gobel and Aubrey de Grey at the American Aging Association . The prize for longevity was first won by a research team led by Andrzej Bartke of Southern Illinois University . The prize for rejuvenation first went to Stephen Spindler of

2208-693: Was developed through a workshop in May 2015 in Washington, D.C. , along with a subsequent roundtable held by the Office of Science and Technology Policy . It is funded from the National Science Foundation and Methuselah Foundation. Two follow-up perspectives were published, "The Promise of Organ and Tissue Preservation to Transform Medicine" and "Bioengineering Priorities on a Path to Ending Organ Shortage". In 2016, NASA in partnership with

2256-444: Was formed to study why supercentenarians , people over 110 years of age, live longer than most, and why they die. Eight autopsies of supercentenarians were conducted by SRF, with six indicating senile cardiac transthyretin amyloidosis at the time of death. With this disease, a defective protein "amasses in and clogs blood vessels, forcing the heart to work harder and eventually fail." From 2003 to 2009, Methuselah Foundation served as

2304-684: Was pledging $ 3.5 million to the Methuselah Foundation and the SENS programs "to support scientific research into the alleviation and eventual reversal of the debilities caused by aging". In 2007, Justin Bonomo , a professional poker player, pledged 5% of his tournament winnings to SENS research. In January 2018, the anonymous principal of the Pineapple Fund donated $ 1 million to the Methuselah Foundation, in addition to $ 2 million donated to SENS Research Foundation. On May 12, 2021, Vitalik Buterin ,

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