119-554: Nucleosome Remodeling Factor (NURF) is an ATP-dependent chromatin remodeling complex first discovered in Drosophila melanogaster (fruit fly) that catalyzes nucleosome sliding in order to regulate gene transcription . It contains an ISWI ATPase , making it part of the ISWI family of chromatin remodeling complexes. NURF is highly conserved among eukaryotes and is involved in transcriptional regulation of developmental genes. NURF
238-479: A Mediterranean climate . The south-east ranges from oceanic (Tasmania and coastal Victoria) to humid subtropical (upper half of New South Wales), with the highlands featuring alpine and subpolar oceanic climates . The interior is arid to semi-arid . Driven by climate change , average temperatures have risen more than 1°C since 1960 . Associated changes in rainfall patterns and climate extremes exacerbate existing issues such as drought and bushfires . 2019
357-525: A belt of Brigalow grasslands lie between the coast and the mountains, while inland of the dividing range are large areas of grassland and shrubland. These include the western plains of New South Wales, and the Mitchell Grass Downs and Mulga Lands of inland Queensland. The northernmost point of the mainland is the tropical Cape York Peninsula . The landscapes of the Top End and
476-496: A hypoxia treatment experience decreased thorax length, while hyperoxia produces smaller flight muscles, suggesting negative developmental effects of extreme oxygen levels. Circadian rhythms are also subject to developmental plasticity. Light conditions during development affect daily activity patterns in Drosophila melanogaster , where flies raised under constant dark or light are less active as adults than those raised under
595-824: A large wave of immigration from across Europe , with such immigrants referred to as " New Australians ". This required a relaxation of the white Australia policy , which was justified to Australians using the slogan "populate or perish". A member of the Western Bloc during the Cold War , Australia participated in the Korean War and the Malayan Emergency during the 1950s and the Vietnam War from 1962 to 1972. During this time, tensions over communist influence in society led to unsuccessful attempts by
714-799: A 12-hour light/dark cycle. Temperature is one of the most pervasive factors influencing arthropod development. In Drosophila melanogaster temperature-induced developmental plasticity can be beneficial and/or detrimental. Most often lower developmental temperatures reduce growth rates which influence many other physiological factors. For example, development at 25 °C increases walking speed, thermal performance breadth , and territorial success, while development at 18 °C increases body mass, wing size, all of which are tied to fitness. Moreover, developing at certain low temperatures produces proportionally large wings which improve flight and reproductive performance at similarly low temperatures ( See acclimation ). Australia Australia , officially
833-419: A cluster of spiky hairs (claspers) surrounding the reproducing parts used to attach to the female during mating. Extensive images are found at FlyBase . Drosophila melanogaster can be distinguished from related species by the following combination of features: gena ~1/10 diameter of eye at greatest vertical height; wing hyaline and with costal index 2.4; male protarsus with a single row of ~12 setae forming
952-470: A common origin. Its geographic range includes all continents, including islands. D. melanogaster is a common pest in homes, restaurants, and other places where food is served. Flies belonging to the family Tephritidae are also called "fruit flies". This can cause confusion, especially in the Mediterranean, Australia , and South Africa , where the Mediterranean fruit fly Ceratitis capitata
1071-461: A date which later became Australia's national day . Most early settlers were convicts , transported for petty crimes and assigned as labourers or servants to "free settlers" (willing immigrants). Once emancipated , convicts tended to integrate into colonial society. Convict rebellions and uprisings were suppressed under martial law, which lasted for two years following the 1808 Rum Rebellion , Australia's only successful coup d'état . During
1190-448: A few hundred, very long (1.76 mm) sperm cells in seminal fluid to the female. Females store the sperm in a tubular receptacle and in two mushroom-shaped spermathecae ; sperm from multiple matings compete for fertilization. A last male precedence is believed to exist; the last male to mate with a female sires about 80% of her offspring. This precedence was found to occur through both displacement and incapacitation. The displacement
1309-560: A fully formed adult fruit fly. Males perform a sequence of five behavioral patterns to court females. First, males orient themselves while playing a courtship song by horizontally extending and vibrating their wings. Soon after, the male positions himself at the rear of the female's abdomen in a low posture to tap and lick the female genitalia. Finally, the male curls his abdomen and attempts copulation. Females can reject males by moving away, kicking, and extruding their ovipositor. Copulation lasts around 15–20 minutes, during which males transfer
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#17327937866321428-578: A genetic model for several human diseases including the neurodegenerative disorders Parkinson's , Huntington's , spinocerebellar ataxia and Alzheimer's disease . The fly is also being used to study mechanisms underlying aging and oxidative stress , immunity , diabetes , and cancer , as well as drug abuse . The life cycle of this insect has four stages: fertilized egg, larva, pupa, and adult. Embryogenesis in Drosophila has been extensively studied, as its small size, short generation time, and large brood size makes it ideal for genetic studies. It
1547-529: A greater mating efficiency for experienced males over naïve males. This modification also appears to have obvious evolutionary advantages, as increased mating efficiency is extremely important in the eyes of natural selection . Both male and female D. melanogaster flies act polygamously (having multiple sexual partners at the same time). In both males and females, polygamy results in a decrease in evening activity compared to virgin flies, more so in males than females. Evening activity consists of those in which
1666-778: A laboratory known as the Fly Room. The Fly Room was cramped with eight desks, each occupied by students and their experiments. They started off experiments using milk bottles to rear the fruit flies and handheld lenses for observing their traits. The lenses were later replaced by microscopes, which enhanced their observations. Morgan and his students eventually elucidated many basic principles of heredity, including sex-linked inheritance, epistasis , multiple alleles, and gene mapping . D. melanogaster had historically been used in laboratories to study genetics and patterns of inheritance. However, D. melanogaster also has importance in environmental mutagenesis research, allowing researchers to study
1785-581: A settlement was established in Van Diemen's Land (present-day Tasmania ), and in 1813, Gregory Blaxland , William Lawson and William Wentworth crossed the Blue Mountains west of Sydney, opening the interior to European settlement. The British claim extended to the whole Australian continent in 1827 when Major Edmund Lockyer established a settlement on King George Sound (modern-day Albany ). The Swan River Colony (present-day Perth )
1904-443: A sex comb; male epandrial posterior lobe small and nearly triangular; female abdominal tergite 6 with dark band running to its ventral margin; female oviscapt small, pale, without dorsodistal depression and with 12-13 peg-like outer ovisensilla. Drosophila melanogaster flies can sense air currents with the hairs on their backs. Their eyes are sensitive to slight differences in light intensity and will instinctively fly away when
2023-510: A shadow or other movement is detected. Under optimal growth conditions at 25 °C (77 °F), the D. melanogaster lifespan is about 50 days from egg to death. The developmental period for D. melanogaster varies with temperature, as with many ectothermic species. The shortest development time (egg to adult), seven days, is achieved at 28 °C (82 °F). Development times increase at higher temperatures (11 days at 30 °C or 86 °F) due to heat stress. Under ideal conditions,
2142-562: A short distance off the north-east coast and extends for more than 2,000 km (1,200 mi). Mount Augustus , claimed to be the world's largest monolith, is located in Western Australia. At 2,228 m (7,310 ft), Mount Kosciuszko is the highest mountain on the Australian mainland. Even taller are Mawson Peak , at 2,745 m (9,006 ft), on the remote Australian external territory of Heard Island , and, in
2261-411: A wide variety of landscapes, with tropical rainforests in the north-east, mountain ranges in the south-east, south-west and east, and desert in the centre. The desert or semi-arid land commonly known as the outback makes up by far the largest portion of land. Australia is the driest inhabited continent; its annual rainfall averaged over continental area is less than 500 mm. The population density
2380-436: Is 3.4 inhabitants per square kilometre, although the large majority of the population lives along the temperate south-eastern coastline. The population density exceeds 19,500 inhabitants per square kilometre in central Melbourne. In 2021 Australia had 10% of the global permanent meadows and pastureland. Forest cover is around 17% of Australia's total land area. The Great Barrier Reef , the world's largest coral reef, lies
2499-413: Is a constitutional monarchy , a parliamentary democracy and a federation . The country has maintained its mostly unchanged constitution alongside a stable liberal democratic political system since Federation in 1901. It is one of the world's oldest federations, in which power is divided between the federal and state governments. The Australian system of government combines elements derived from
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#17327937866322618-447: Is a holometabolous insect, so it undergoes a full metamorphosis. Their life cycle is broken down into four stages: embryo, larva, pupa, adult. The eggs, which are about 0.5 mm long, hatch after 12–15 hours (at 25 °C or 77 °F). The resulting larvae grow for about four days (at 25 °C) while molting twice (into second- and third-instar larvae), at about 24 and 48 hours after hatching. During this time, they feed on
2737-409: Is also unique among model organisms in that cleavage occurs in a syncytium . During oogenesis, cytoplasmic bridges called "ring canals" connect the forming oocyte to nurse cells. Nutrients and developmental control molecules move from the nurse cells into the oocyte. In the figure to the left, the forming oocyte can be seen to be covered by follicular support cells. After fertilization of the oocyte,
2856-570: Is an ISWI ATPase, distinguishable by its HAND , SANT , and SLIDE domains (SANT-like but with several insertions). The NURF complex in Homo sapiens has three subunits, BPTF , SNF2L , and pRBAP46/48, homologous to NURF301, NURF140, and NURF55, respectively. There is no human homolog for NURF38. NURF interacts with chromatin by binding to modified histones or interacting with various transcription factors . NURF catalyzes nucleosome sliding in either direction on DNA without any apparent modifications to
2975-413: Is an economic pest. The term " Drosophila ", meaning "dew-loving", is a modern scientific Latin adaptation from Greek words δρόσος , drósos , " dew ", and φιλία , philía , "lover". The term " melanogaster " meaning "black-belly", comes from Ancient Greek μέλας , mélas , “black”, and γᾰστήρ , gastḗr , "belly". Unlike humans , the sex and physical appearance of fruit flies
3094-577: Is attributed to sperm handling by the female fly as multiple matings are conducted and is most significant during the first 1–2 days after copulation. Displacement from the seminal receptacle is more significant than displacement from the spermathecae. Incapacitation of first male sperm by second male sperm becomes significant 2–7 days after copulation. The seminal fluid of the second male is believed to be responsible for this incapacitation mechanism (without removal of first male sperm) which takes effect before fertilization occurs. The delay in effectiveness of
3213-443: Is followed by the name of the gene affected and a description of its phenotype. (Note: Recessive alleles are in lower case, while dominant alleles are capitalised.) Drosophila genes are traditionally named after the phenotype they cause when mutated. For example, the absence of a particular gene in Drosophila will result in a mutant embryo that does not develop a heart. Scientists have thus called this gene tinman , named after
3332-453: Is induced by the DNA damaging agents ultraviolet light and mitomycin C . Females become receptive to courting males about 8–12 hours after emergence. Specific neuron groups in females have been found to affect copulation behavior and mate choice. One such group in the abdominal nerve cord allows the female fly to pause her body movements to copulate. Activation of these neurons induces
3451-405: Is involved in neuronal development and has been shown to enhance neurite outgrowth in vitro . Drosophila melanogaster Drosophila melanogaster is a species of fly (an insect of the order Diptera) in the family Drosophilidae . The species is often referred to as the fruit fly or lesser fruit fly , or less commonly the " vinegar fly", " pomace fly", or " banana fly". In
3570-408: Is not influenced by hormones . The appearance and sex of fruit flies is determined only by genetic information. Female fruit flies are substantially larger than male fruit flies, with females having bodies that are up to 30% larger than an adult male. Wild type fruit flies are yellow-brown, with brick-red eyes and transverse black rings across the abdomen. The black portions of the abdomen are
3689-586: Is now Southeast Asia. It is uncertain how many waves of immigration may have contributed to these ancestors of modern Aboriginal Australians. The Madjedbebe rock shelter in Arnhem Land is possibly the oldest site showing the presence of humans in Australia. The oldest human remains found are the Lake Mungo remains , which have been dated to around 41,000 years ago. Aboriginal Australian culture
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3808-629: Is one of only two pristine Archaean 3.6–2.7 Ga (billion years ago) crusts identified on the Earth. Having been part of all major supercontinents , the Australian continent began to form after the breakup of Gondwana in the Permian , with the separation of the continental landmass from the African continent and Indian subcontinent. It separated from Antarctica over a prolonged period beginning in
3927-422: Is one of the most widely used and genetically best-known of all eukaryotic organisms. All organisms use common genetic systems; therefore, comprehending processes such as transcription and replication in fruit flies helps in understanding these processes in other eukaryotes, including humans . Thomas Hunt Morgan began using fruit flies in experimental studies of heredity at Columbia University in 1910 in
4046-466: Is one of the oldest continuous cultures on Earth. At the time of first European contact, Aboriginal Australians belonged to wide range of societies, with diverse economies spread across at least 250 different language groups . Estimates of the Aboriginal population before British settlement range from 300,000 to 3 million. Aboriginal Australians cultures were (and remain) deeply connected with
4165-409: Is relatively very small and therefore often ignored, aside from its important eyeless gene. The D. melanogaster sequenced genome of 139.5 million base pairs has been annotated and contains around 15,682 genes according to Ensemble release 73. More than 60% of the genome appears to be functional non-protein-coding DNA involved in gene expression control. Determination of sex in Drosophila occurs by
4284-491: Is sent to a brain region that is a homolog of the hypothalamus and the hypothalamus then controls sexual behavior and desire. Gonadotropic hormones in Drosophila maintain homeostasis and govern reproductive output via a cyclic interrelationship, not unlike the mammalian estrous cycle . Sex peptide perturbs this homeostasis and dramatically shifts the endocrine state of the female by inciting juvenile hormone synthesis in
4403-411: Is unique. About 85% of flowering plants, 84% of mammals, more than 45% of birds , and 89% of in-shore, temperate-zone fish are endemic . Australia has at least 755 species of reptile, more than any other country in the world. Besides Antarctica, Australia is the only continent that developed without feline species. Feral cats may have been introduced in the 17th century by Dutch shipwrecks, and later in
4522-768: The Colonial Office that it be formally adopted. In 1824, the Admiralty agreed that the continent should be known officially by that name. The first official published use of the new name came with the publication in 1830 of The Australia Directory by the Hydrographic Office . Colloquial names for Australia include " Oz ", " Straya " and " Down Under ". Other epithets include "the Great Southern Land", "the Lucky Country" (from
4641-535: The Commonwealth of Australia , is a country comprising the mainland of the Australian continent , the island of Tasmania and numerous smaller islands . Australia has a total area of 7,688,287 km (2,968,464 sq mi), making it the sixth-largest country in the world and the largest country by area in Oceania . It is the world's oldest, flattest, and driest inhabited continent, with some of
4760-400: The D. melanogaster homolog of WRN also cause increased physiologic signs of aging, such as shorter lifespan, higher tumor incidence, muscle degeneration, reduced climbing ability, altered behavior and reduced locomotor activity. Meiotic recombination in D. melanogaster appears to be employed in repairing damage in germ-line DNA as indicated by the findings that meiotic recombination
4879-595: The Gulf Country —with their tropical climate—include forest, woodland, wetland, grassland, rainforest and desert. At the north-west corner of the continent are the sandstone cliffs and gorges of The Kimberley , and below that the Pilbara . The Victoria Plains tropical savanna lies south of the Kimberley and Arnhem Land savannas, forming a transition between the coastal savannas and the interior deserts. At
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4998-551: The Indian Ocean Dipole and the El Niño–Southern Oscillation , which is correlated with periodic drought , and the seasonal tropical low-pressure system that produces cyclones in northern Australia. These factors cause rainfall to vary markedly from year to year. Much of the northern part of the country has a tropical, predominantly summer-rainfall ( monsoon ). The south-west corner of the country has
5117-539: The Iraq War from 2003 to 2009. The nation's trade relations also became increasingly oriented towards East Asia in the 21st century, with China becoming the nation's largest trading partner by a large margin. In 2020, during the COVID-19 pandemic , several of Australia's largest cities were locked down for extended periods and free movement across the national and state borders was restricted in an attempt to slow
5236-664: The Menzies Government to ban the Communist Party of Australia , and a bitter split in the Labor Party in 1955. As a result of a 1967 referendum , the federal government gained the power to legislate with regard to Indigenous Australians, and Indigenous Australians were fully included in the census . Pre-colonial land interests (referred to as native title in Australia) was recognised in law for
5355-622: The Oz character of the same name . Likewise changes in the Shavenbaby gene cause the loss of dorsal cuticular hairs in Drosophila sechellia larvae. This system of nomenclature results in a wider range of gene names than in other organisms. The genome of D. melanogaster (sequenced in 2000, and curated at the FlyBase database ) contains four pairs of chromosomes – an X/Y pair, and three autosomes labeled 2, 3, and 4. The fourth chromosome
5474-738: The Pacific Community ; the Commonwealth of Nations ; and the defence and security organisations ANZUS , AUKUS , and the Five Eyes . It is also a major non-NATO ally of the United States. The name Australia (pronounced / ə ˈ s t r eɪ l i ə / in Australian English ) is derived from the Latin Terra Australis ( ' southern land ' ), a name used for a hypothetical continent in
5593-532: The Permian and continuing through to the Cretaceous . When the last glacial period ended in about 10,000 BC, rising sea levels formed Bass Strait , separating Tasmania from the mainland. Then between about 8,000 and 6,500 BC, the lowlands in the north were flooded by the sea, separating New Guinea, the Aru Islands , and the mainland of Australia. The Australian continent is moving toward Eurasia at
5712-686: The Territory of Papua and New Guinea in 1949 and gained independence from Australia in 1975. In 1914, Australia joined the Allies in fighting the First World War, and took part in many of the major battles fought on the Western Front . Of about 416,000 who served, about 60,000 were killed and another 152,000 were wounded. Many Australians regard the defeat of the Australian and New Zealand Army Corps (ANZAC) at Gallipoli in 1915 as
5831-528: The Torres Strait Islands . The Dutch charted the whole of the western and northern coastlines and named the island continent " New Holland " during the 17th century, and although no attempt at settlement was made, a number of shipwrecks left men either stranded or, as in the case of the Batavia in 1629, marooned for mutiny and murder, thus becoming the first Europeans to permanently inhabit
5950-517: The X:A ratio of X chromosomes to autosomes, not because of the presence of a Y chromosome as in human sex determination. Although the Y chromosome is entirely heterochromatic , it contains at least 16 genes, many of which are thought to have male-related functions. There are three transferrin orthologs, all of which are dramatically divergent from those known in chordate models. A June 2001 study by National Human Genome Research Institute comparing
6069-696: The bombing of Darwin and other Japanese attacks on Australian soil , led to a widespread belief in Australia that a Japanese invasion was imminent , and a shift from the United Kingdom to the United States as Australia's principal ally and security partner. Since 1951, Australia has been allied with the United States under the ANZUS treaty. In the decades following World War II, Australia enjoyed significant increases in living standards, leisure time and suburban development. Governments encouraged
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#17327937866326188-426: The emu and the kookaburra . Australia is home to many dangerous animals including some of the most venomous snakes in the world. The dingo was introduced by Austronesian people who traded with Indigenous Australians around 3000 BCE . Many animal and plant species became extinct soon after first human settlement, including the Australian megafauna ; others have disappeared since European settlement, among them
6307-595: The governor-general at the federal level and by the governors at the state level, who by section 63 of the Constitution and convention act on the advice of their ministers. Thus, in practice the governor-general acts as a legal figurehead for the actions of the prime minister and the Cabinet. The governor-general may in some situations exercise reserve powers : powers exercisable in the absence or contrary to ministerial advice. When these powers may be exercised
6426-505: The histone octamer itself. NURF is essential for the expression of homeotic genes. The ISWI ATPase specifically recognizes intact N-terminal histone tails. In Drosophila , NURF interacts with the transcription factor GAGA to remodel chromatin at the hsp70 promoter, and null mutations in the Nurf301 subunit prevent larval metamorphosis . Other NURF mutants cause the development of melanotic tumors from larval blood cells. In humans, hNURF
6545-409: The mesoderm , and posterior and anterior invagination of endoderm (gut), as well as extensive body segmentation until finally hatching from the surrounding cuticle into a first-instar larva. During larval development, tissues known as imaginal discs grow inside the larva. Imaginal discs develop to form most structures of the adult body, such as the head, legs, wings, thorax, and genitalia. Cells of
6664-429: The microorganisms that decompose the fruit, as well as on the sugar of the fruit itself. The mother puts feces on the egg sacs to establish the same microbial composition in the larvae's guts that has worked positively for herself. Then the larvae encapsulate in the puparium and undergo a four-day-long metamorphosis (at 25 °C), after which the adults eclose (emerge). Drosophila melanogaster, commonly known as
6783-661: The "baptism of fire" that forged the new nation's identity . The beginning of the campaign is commemorated annually on Anzac Day , a date which rivals Australia Day as the nation's most important. From 1939 to 1945, Australia joined the Allies in fighting the Second World War. Australia's armed forces fought in the Pacific , European and Mediterranean and Middle East theatres . The shock of Britain's defeat in Singapore in 1942, followed soon after by
6902-587: The "island continent" and is sometimes considered the world's largest island . Australia has 34,218 km (21,262 mi) of coastline (excluding all offshore islands), and claims an extensive exclusive economic zone of 8,148,250 square kilometres (3,146,060 sq mi). This exclusive economic zone does not include the Australian Antarctic Territory . Mainland Australia lies between latitudes 9° and 44° south , and longitudes 112° and 154° east . Australia's size gives it
7021-428: The 18th century by European settlers. They are now considered a major factor in the decline and extinction of many vulnerable and endangered native species. Seafaring immigrants from Asia are believed to have brought the dingo to Australia sometime after the end of the last ice age—perhaps 4000 years ago—and Aboriginal people helped disperse them across the continent as pets, contributing to the demise of thylacines on
7140-539: The 1964 book of the same name ), "the Sunburnt Country", and "the Wide Brown Land". The latter two both derive from Dorothea Mackellar 's 1908 poem " My Country ". Indigenous Australians comprise two broad groups: Human habitation of the Australian continent is estimated to have begun 50,000 to 65,000 years ago, with the migration of people by land bridges and short sea crossings from what
7259-543: The 2018 Environmental Performance Index . There are more than 1,800 animals and plants on Australia's threatened species list, including more than 500 animals. Paleontologists discovered a fossil site of a prehistoric rainforest in McGraths Flat , in South Australia, that presents evidence that this now arid desert and dry shrubland / grassland was once home to an abundance of life. Australia
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#17327937866327378-656: The Australian Antarctic Territory, Mount McClintock and Mount Menzies , at 3,492 m (11,457 ft) and 3,355 m (11,007 ft) respectively. Eastern Australia is marked by the Great Dividing Range , which runs parallel to the coast of Queensland, New South Wales and much of Victoria. The name is not strictly accurate, because parts of the range consist of low hills, and the highlands are typically no more than 1,600 m (5,200 ft) in height. The coastal uplands and
7497-558: The Australian mainland. The first ship and crew to chart the Australian coast and meet with Aboriginal people was the Duyfken , captained by Dutch navigator Willem Janszoon . He sighted the coast of Cape York Peninsula in early 1606, and made landfall on 26 February 1606 at the Pennefather River near the modern town of Weipa on Cape York. Later that year, Spanish explorer Luís Vaz de Torres sailed through and navigated
7616-611: The Commonwealth of Australia. This continued a process of increasing autonomy from the United Kingdom, highlighted by the Statute of Westminster Adoption Act 1942 , and culminating in the Australia Acts of 1986. Australia is a federal parliamentary democracy and constitutional monarchy comprising six states and ten territories . Its population of more than 28 million is highly urbanised and heavily concentrated on
7735-709: The Southern Hemisphere since ancient times. Several 16th-century cartographers used the word Australia on maps, but not to identify modern Australia. When Europeans began visiting and mapping Australia in the 17th century, the name Terra Australis was applied to the new territories. Until the early 19th century, Australia was best known as New Holland , a name first applied by the Dutch explorer Abel Tasman in 1644 (as Nieuw-Holland ) and subsequently anglicised. Terra Australis still saw occasional usage, such as in scientific texts. The name Australia
7854-632: The centre and Phanerozoic sedimentary basins , metamorphic and igneous rocks in the east. The Australian mainland and Tasmania are situated in the middle of the tectonic plate and have no active volcanoes, but due to passing over the East Australia hotspot , recent volcanism has occurred during the Holocene , in the Newer Volcanics Province of western Victoria and south-eastern South Australia. Volcanism also occurs in
7973-484: The colonies was achieved after a decade of planning, constitutional conventions and referendums , resulting in the establishment of the Commonwealth of Australia as a nation under the new Australian Constitution . After the 1907 Imperial Conference , Australia and several other self-governing British settler colonies were given the status of self-governing dominions within the British Empire. Australia
8092-847: The continent. In 1770, Captain James Cook sailed along and mapped the east coast, which he named " New South Wales " and claimed for Great Britain. Following the loss of its American colonies in 1783, the British Government sent a fleet of ships, the First Fleet , under the command of Captain Arthur Phillip , to establish a new penal colony in New South Wales . A camp was set up and the Union Flag raised at Sydney Cove , Port Jackson , on 26 January 1788,
8211-594: The convict system culminated in its abolition in the eastern colonies by the 1850s. Initially a free colony, Western Australia practised penal transportation from 1850 to 1868. The six colonies individually gained responsible government between 1855 and 1890, thus becoming elective democracies managing most of their own affairs while remaining part of the British Empire . The Colonial Office in London retained control of some matters, notably foreign affairs. In
8330-906: The copulation of others). This behavior is sensitive to environmental conditions, and females copulate less in bad weather conditions. D. melanogaster males exhibit a strong reproductive learning curve. That is, with sexual experience, these flies tend to modify their future mating behavior in multiple ways. These changes include increased selectivity for courting only intraspecifically, as well as decreased courtship times. Sexually naïve D. melanogaster males are known to spend significant time courting interspecifically, such as with D. simulans flies. Naïve D. melanogaster will also attempt to court females that are not yet sexually mature, and other males. D. melanogaster males show little to no preference for D. melanogaster females over females of other species or even other male flies. However, after D. simulans or other flies incapable of copulation have rejected
8449-421: The corpus allatum. D. melanogaster is often used for life extension studies, such as to identify genes purported to increase lifespan when mutated . D. melanogaster is also used in studies of aging . Werner syndrome is a condition in humans characterized by accelerated aging. It is caused by mutations in the gene WRN that encodes a protein with essential roles in repair of DNA damage. Mutations in
8568-735: The country's economy. It ranks highly for quality of life, health, education, economic freedom, civil liberties and political rights. Australia is a middle power , and has the world's thirteenth-highest military expenditure . It is a member of international groups including the United Nations; the G20 ; the OECD ; the World Trade Organization ; Asia-Pacific Economic Cooperation ; the Pacific Islands Forum ;
8687-454: The development time at 25 °C (77 °F) is 8 + 1 ⁄ 2 days, at 18 °C (64 °F) it takes 19 days and at 12 °C (54 °F) it takes over 50 days. Under crowded conditions, development time increases, while the emerging flies are smaller. Females lay some 400 eggs (embryos), about five at a time, into rotting fruit or other suitable material such as decaying mushrooms and sap fluxes . Drosophila melanogaster
8806-459: The early 2010s after the 2000s Australian drought . Although most of Australia is semi-arid or desert, the continent includes a diverse range of habitats from alpine heaths to tropical rainforests . Fungi typify that diversity—an estimated 250,000 species—of which only 5% have been described—occur in Australia. Because of the continent's great age, extremely variable weather patterns, and long-term geographic isolation, much of Australia's biota
8925-405: The early embryo (or syncytial embryo ) undergoes rapid DNA replication and 13 nuclear divisions until about 5000 to 6000 nuclei accumulate in the unseparated cytoplasm of the embryo. By the end of the eighth division, most nuclei have migrated to the surface, surrounding the yolk sac (leaving behind only a few nuclei, which will become the yolk nuclei). After the 10th division, the pole cells form at
9044-481: The eastern seaboard. Canberra is the nation's capital, while its most populous cities are Sydney and Melbourne , both with a population of more than 5 million. Australia's culture is diverse, and the country has one of the highest foreign-born populations in the world . It has a highly developed market economy and one of the highest per capita incomes globally . Its abundant natural resources and well-developed international trade relations are crucial to
9163-406: The effects of specific environmental mutagens. There are many reasons the fruit fly is a popular choice as a model organism: Genetic markers are commonly used in Drosophila research, for example within balancer chromosomes or P-element inserts, and most phenotypes are easily identifiable either with the naked eye or under a microscope. In the list of a few common markers below, the allele symbol
9282-451: The female fruit fly and are present in the early stages of embryo development. They determine the embryo's main features and early development. For example, the gene called Bicoid regulates the formation of the embryo's anterior end, and its absence leads to an embryo lacking a head. Zygotic genes: These genes are activated in later stages of embryo development when the fruit fly embryo begins to produce its own genetic products. For example,
9401-494: The female to cease movement and orient herself towards the male to allow for mounting. If the group is inactivated, the female remains in motion and does not copulate. Various chemical signals such as male pheromones often are able to activate the group. Also, females exhibit mate choice copying . When virgin females are shown other females copulating with a certain type of male, they tend to copulate more with this type of male afterwards than naïve females (which have not observed
9520-772: The first time when the High Court of Australia held in Mabo v Queensland (No 2) that Australia was neither terra nullius ( ' land belonging to no one ' ) or "desert and uncultivated land" at the time of European settlement. Following the abolition of the last vestiges of the White Australia policy in 1973, Australia's demography and culture transformed as a result of a large and ongoing wave of non-European immigration, mostly from Asia. The late 20th century also saw an increasing focus on foreign policy ties with other Pacific Rim nations. The Australia Acts severed
9639-492: The flies participate other than mating and finding partners, such as finding food. The reproductive success of males and females varies, because a female only needs to mate once to reach maximum fertility. Mating with multiple partners provides no advantage over mating with one partner, so females exhibit no difference in evening activity between polygamous and monogamous individuals. For males, however, mating with multiple partners increases their reproductive success by increasing
9758-413: The fruit fly and human genome estimated that about 60% of genes are conserved between the two species. About 75% of known human disease genes have a recognizable match in the genome of fruit flies, and 50% of fly protein sequences have mammalian homologs . An online database called Homophila is available to search for human disease gene homologues in flies and vice versa. Drosophila is being used as
9877-485: The fruit fly, has been a significant model organism in embryonic development research. Many of its genes that regulate embryonic development and their mechanisms of action have been crucial in understanding the fundamental principles of embryonic development regulation in many multicellular organisms, including humans. Here are some important genes regulating embryonic development in Drosophila melanogaster and their modes of action: Maternal genes: These genes are encoded in
9996-529: The genetic diversity of their offspring. This benefit of genetic diversity is an evolutionary advantage because it increases the chance that some of the offspring will have traits that increase their fitness in their environment. The difference in evening activity between polygamous and monogamous male flies can be explained with courtship. For polygamous flies, their reproductive success increases by having offspring with multiple partners, and therefore they spend more time and energy on courting multiple females. On
10115-467: The gradient. For example, the Hedgehog morphogen regulates the differentiation of segments and segment identity in the fruit fly embryo. These genes and their modes of action form a complex regulatory network that guides the embryonic development of Drosophila melanogaster. They influence cell differentiation, segment formation, and axial patterning in the embryo, ultimately leading to the development of
10234-412: The heart of the country are the uplands of central Australia . Prominent features of the centre and south include Uluru (also known as Ayers Rock), the famous sandstone monolith, and the inland Simpson , Tirari and Sturt Stony , Gibson , Great Sandy, Tanami , and Great Victoria deserts, with the famous Nullarbor Plain on the southern coast. The Western Australian mulga shrublands lie between
10353-482: The hunchback gene regulates the formation of segments in the embryo. Homeotic genes: This gene family regulates segmentation and axial patterning in development. They act as regulatory factors that determine cell fate in embryonic development. For example, the gene called Antennapedia regulates the formation of anterior limbs in the embryo. Morphogens: These are molecules that form gradients in embryonic development and regulate cell fate depending on their position in
10472-768: The imaginal disks are set aside during embryogenesis and continue to grow and divide during the larval stages—unlike most other cells of the larva, which have differentiated to perform specialized functions and grow without further cell division. At metamorphosis, the larva forms a pupa , inside which the larval tissues are reabsorbed and the imaginal tissues undergo extensive morphogenetic movements to form adult structures. Biotic and abiotic factors experienced during development will affect developmental resource allocation leading to phenotypic variation , also referred to as developmental plasticity. As in all insects, environmental factors can influence several aspects of development in Drosophila melanogaster . Fruit flies reared under
10591-486: The incapacitation mechanism is believed to be a protective mechanism that prevents a male fly from incapacitating his own sperm should he mate with the same female fly repetitively. Sensory neurons in the uterus of female D. melanogaster respond to a male protein, sex peptide , which is found in semen. This protein makes the female reluctant to copulate for about 10 days after insemination . The signal pathway leading to this change in behavior has been determined. The signal
10710-433: The inspiration for the species name ( melanogaster = "black-bellied" ). The brick-red color of the eyes of the wild type fly are due to two pigments: xanthommatin, which is brown and is derived from tryptophan , and drosopterins, which are red and are derived from guanosine triphosphate . They exhibit sexual dimorphism ; females are about 2.5 mm (0.10 in) long; males are slightly smaller. Furthermore, males have
10829-479: The interior deserts and Mediterranean-climate Southwest Australia . Lying on the Indo-Australian Plate , the mainland of Australia is the lowest and most primordial landmass on Earth with a relatively stable geological history. The landmass includes virtually all known rock types and from all geological time periods spanning more than 3.8 billion years of the Earth's history. The Pilbara Craton
10948-417: The island of New Guinea (considered geologically as part of the Australian continent), and in the Australian external territory of Heard Island and McDonald Islands . Seismic activity in the Australian mainland and Tasmania is also low, with the greatest number of fatalities having occurred in the 1989 Newcastle earthquake . The climate of Australia is significantly influenced by ocean currents, including
11067-620: The land and the environment, with stories of The Dreaming maintained through oral tradition , songs , dance and paintings. Certain groups engaged in fire-stick farming , fish farming , and built semi-permanent shelters . These practices have variously been characterised as " hunter-gatherer ", " agricultural ", "natural cultivation" and "intensification". Torres Strait Islander people first settled their islands at least 2,500 years ago. Culturally and linguistically distinct from mainland Aboriginal peoples, they were seafarers and obtained their livelihood from seasonal horticulture and
11186-447: The least fertile soils. It is a megadiverse country , and its size gives it a wide variety of landscapes and climates including deserts in the interior and tropical rainforests along the coast . The ancestors of Aboriginal Australians began arriving from south-east Asia 50,000 to 65,000 years ago, during the last glacial period . By the time of British settlement, Aboriginal Australians spoke 250 distinct languages and had
11305-494: The location for the future federal capital of Canberra . While it was being constructed, Melbourne served as the temporary capital from 1901 to 1927. The Northern Territory was transferred from the control of South Australia to the Commonwealth in 1911. Australia became the colonial ruler of the Territory of Papua (which had initially been annexed by Queensland in 1883) in 1902 and of the Territory of New Guinea (formerly German New Guinea ) in 1920. The two were unified as
11424-448: The mainland. Australia is also one of 17 megadiverse countries. Australian forests are mostly made up of evergreen species, particularly eucalyptus trees in the less arid regions; wattles replace them as the dominant species in drier regions and deserts. Among well-known Australian animals are the monotremes (the platypus and echidna ); a host of marsupials , including the kangaroo , koala , and wombat , and birds such as
11543-582: The males' advances, D. melanogaster males are much less likely to spend time courting nonspecifically in the future. This apparent learned behavior modification seems to be evolutionarily significant, as it allows the males to avoid investing energy into futile sexual encounters. In addition, males with previous sexual experience modify their courtship dance when attempting to mate with new females—the experienced males spend less time courting, so have lower mating latencies, meaning that they are able to reproduce more quickly. This decreased mating latency leads to
11662-474: The mid-19th century, explorers such as Burke and Wills charted Australia's interior. A series of gold rushes beginning in the early 1850s led to an influx of new migrants from China , North America and continental Europe, as well as outbreaks of bushranging and civil unrest; the latter peaked in 1854 when Ballarat miners launched the Eureka Rebellion against gold license fees. The 1860s saw
11781-602: The next two decades, social and economic reforms, together with the establishment of a Legislative Council and Supreme Court , saw the penal colony transition to a civil society. The indigenous population declined for 150 years following European settlement, mainly due to infectious disease. British colonial authorities did not sign any treaties with Aboriginal groups . As settlement expanded, tens of thousands of Indigenous people and thousands of settlers were killed in frontier conflicts while settlers dispossessed surviving Indigenous peoples of most of their land. In 1803,
11900-638: The nuclei that have made a mistake detach from their centrosomes and fall into the centre of the embryo (yolk sac), which will not form part of the fly. The gene network (transcriptional and protein interactions) governing the early development of the fruit fly embryo is one of the best understood gene networks to date, especially the patterning along the anteroposterior (AP) and dorsoventral (DV) axes (See under morphogenesis ). The embryo undergoes well-characterized morphogenetic movements during gastrulation and early development, including germ-band extension , formation of several furrows, ventral invagination of
12019-498: The oldest living culture in the world. Australia's written history commenced with Dutch exploration of most of the coastline in the 17th-century. British colonisation began in 1788 with the establishment of the penal colony of New South Wales . By the mid-19th century, most of the continent had been explored by European settlers and five additional self-governing British colonies were established, each gaining responsible government by 1890. The colonies federated in 1901, forming
12138-458: The other hand, monogamous flies only court one female, and expend less energy doing so. While it requires more energy for male flies to court multiple females, the overall reproductive benefits it produces has kept polygamy as the preferred sexual choice. The mechanism that affects courtship behavior in Drosophila is controlled by the oscillator neurons DN1s and LNDs. Oscillation of the DN1 neurons
12257-428: The political systems of the United Kingdom (a fused executive , constitutional monarchy and strong party discipline ) and the United States ( federalism , a written constitution and strong bicameralism with an elected upper house), resulting in a distinct hybrid. Federal government power is partially separated between three groups: Charles III reigns as King of Australia and is represented in Australia by
12376-482: The posterior end of the embryo, segregating the germ line from the syncytium. Finally, after the 13th division, cell membranes slowly invaginate, dividing the syncytium into individual somatic cells. Once this process is completed, gastrulation starts. Nuclear division in the early Drosophila embryo happens so quickly, no proper checkpoints exist, so mistakes may be made in division of the DNA. To get around this problem,
12495-594: The protection of threatened species. Numerous protected areas have been created under the National Strategy for the Conservation of Australia's Biological Diversity to protect and preserve unique ecosystems; 65 wetlands are listed under the Ramsar Convention , and 16 natural World Heritage Sites have been established. Australia was ranked 21st out of 178 countries in the world on
12614-480: The rate of 6 to 7 centimetres a year. The Australian mainland's continental crust , excluding the thinned margins, has an average thickness of 38 km, with a range in thickness from 24 km to 59 km. Australia's geology can be divided into several main sections, showcasing that the continent grew from west to east: the Archaean cratonic shields found mostly in the west, Proterozoic fold belts in
12733-545: The remaining constitutional ties between Australia and the United Kingdom while maintaining the monarch in her independent capacity as Queen of Australia . In a 1999 constitutional referendum , 55% of voters rejected abolishing the monarchy and becoming a republic. Following the September 11 attacks on the United States, Australia joined the United States in fighting the Afghanistan War from 2001 to 2021 and
12852-419: The resources of their reefs and seas. Agriculture also developed on some islands and villages appeared by the 1300s. By the mid-18th century in northern Australia, contact, trade and cross-cultural engagement had been established between local Aboriginal groups and Makassan trepangers , visiting from present-day Indonesia. The Dutch are the first Europeans that recorded sighting and making landfall on
12971-491: The rise of blackbirding , where South Sea Islanders were coerced or abducted into indentured labour, mainly by Queensland colonists. From 1886, Australian colonial governments began removing many Aboriginal children from their families and communities, justified on the grounds of child protection and forced assimilation policies. The Second Boer War (1899–1902) marked the largest overseas deployment of Australia's colonial forces . On 1 January 1901, federation of
13090-741: The spread of the SARS-CoV-2 virus . Surrounded by the Indian and Pacific oceans, Australia is separated from Asia by the Arafura and Timor seas, with the Coral Sea lying off the Queensland coast, and the Tasman Sea lying between Australia and New Zealand. The world's smallest continent and sixth-largest country by total area , Australia—owing to its size and isolation—is often dubbed
13209-406: The thylacine. Many of Australia's ecoregions, and the species within those regions, are threatened by human activities and introduced animal, chromistan , fungal and plant species. All these factors have led to Australia's having the highest mammal extinction rate of any country in the world. The federal Environment Protection and Biodiversity Conservation Act 1999 is the legal framework for
13328-416: The wild, D. melanogaster are attracted to rotting fruit and fermenting beverages, and are often found in orchards, kitchens and pubs. Starting with Charles W. Woodworth 's 1901 proposal of the use of this species as a model organism , D. melanogaster continues to be widely used for biological research in genetics , physiology , microbial pathogenesis , and life history evolution . D. melanogaster
13447-615: Was Australia's warmest recorded year, and the 2019–2020 bushfire season was the country's worst on record . Australia's greenhouse gas emissions per capita are among the highest in the world. Water restrictions are frequently in place in many regions and cities of Australia in response to chronic shortages due to urban population increases and localised drought. Throughout much of the continent, major flooding regularly follows extended periods of drought, flushing out inland river systems, overflowing dams and inundating large inland flood plains, as occurred throughout Eastern Australia in
13566-413: Was established in 1829, evolving into the largest Australian colony by area, Western Australia . In accordance with population growth, separate colonies were carved from New South Wales: Tasmania in 1825, South Australia in 1836, New Zealand in 1841, Victoria in 1851, and Queensland in 1859. South Australia was founded as a free colony—it never accepted transported convicts. Growing opposition to
13685-467: Was first purified from the model organism Drosophila melanogaster by Toshio Tsukiyama and Carl Wu in 1995. Tsukiyama and Wu described NURF’s chromatin remodeling activity on the hsp70 promoter . It was later discovered that NURF regulates transcription in this manner for hundreds of genes. A human ortholog of NURF, called hNURF, was isolated in 2003. The NURF complex in Drosophila contains four subunits: NURF301, NURF140, NURF55, and NURF38. NURF140
13804-416: Was found to be effected by sociosexual interactions , and is connected to mating-related decrease of evening activity. D. melanogaster remains one of the most studied organisms in biological research, particularly in genetics and developmental biology. It is also employed in studies of environmental mutagenesis. D. melanogaster was among the first organisms used for genetic analysis , and today it
13923-579: Was one of the founding members of the League of Nations in 1920, and the United Nations in 1945. The Statute of Westminster 1931 formally ended the ability of the UK to pass federal laws without Australia's consent. Australia adopted it in 1942, but it was backdated to 1939 to confirm the validity of legislation passed during World War II. The Australian Capital Territory was formed in 1911 as
14042-470: Was popularised by the explorer Matthew Flinders , who said it was "more agreeable to the ear, and an assimilation to the names of the other great portions of the Earth". The first time that Australia appears to have been officially used was in April 1817, when Governor Lachlan Macquarie acknowledged the receipt of Flinders' charts of Australia from Lord Bathurst . In December 1817, Macquarie recommended to
14161-438: Was the first animal to be launched into space in 1947. As of 2017, six Nobel Prizes have been awarded to drosophilists for their work using the insect. Drosophila melanogaster is typically used in research owing to its rapid life cycle, relatively simple genetics with only four pairs of chromosomes , and large number of offspring per generation. It was originally an African species, with all non-African lineages having
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