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7-512: NXF may refer to: Protein-coding gene members of the NXF family NXF1 NXF2 National LGBT Federation , a non-governmental organisation in Dublin, Ireland Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title NXF . If an internal link led you here, you may wish to change

14-688: Is a protein which in humans is encoded by the NXF1 gene . This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 ( NXT1 ), and a ubiquitin -associated domain that mediates interactions with nucleoporins . Alternative splicing results in transcript variants. The LRRs and NTF2-like domains are required for export activity. The encoded protein of this gene shuttles between

21-792: Is a human protein encoded by the MAGOH gene . This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the germplasm , but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent fibroblasts . Drosophila flies produce unfit progeny when they have mutations in their mago nashi ( Japanese : 孫なし , Hepburn : mago nashi , lit.   ' grandchildless ' ) gene. The progeny have defects in germplasm assembly and germline development. MAGOH interacts with RBM8A and NXF1 . In Drosophila melanogaster , Mago Nashi and Tsunagi/ Y14 are core components of

28-838: Is joined to the next module by flexible 12-residue Pro-rich linker. Nuclear export of mRNAs is mediated by the Tap protein. Tap can form a multimeric complex with itself and with other members of the NXF family. Three functional domains of Tap have been well characterized: the RNA-binding domain, the Nuclear Transport Factor 2 (NTF2)-like domain, and the ubiquitin-associated (UBA) domain. MAGOH 1P27 , 2HYI , 2J0Q , 2J0S , 2XB2 , 3EX7 4116 17149 ENSG00000162385 ENSMUSG00000028609 P61326 P61327 NM_002370 NM_001282737 NP_002361 NP_001269666 Protein mago nashi homolog

35-711: The nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses . A variant allele of the homologous Nxf1 gene in mice suppresses a class of mutations caused by integration of an endogenous retrovirus (intracisternal A particle) into an intron. NXF1 has been shown to interact with TNPO2 , MAGOH , U2 small nuclear RNA auxiliary factor 1 , DHX9 , HuD and NUP214 . In molecular biology, another name for

42-629: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=NXF&oldid=1191049598 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages NXF1 10482 53319 ENSG00000162231 ENSMUSG00000010097 Q9UBU9 Q99JX7 NM_006362 NM_001081491 NM_001276704 NM_016813 NP_001074960 NP_006353 NP_001263633 NP_058093 Nuclear RNA export factor 1 , also known as NXF1 or TAP ,

49-572: The protein NXF1 is TAP. In particular this entry focuses on the C-terminal domain, which also contains the UBA (protein domain) . This entry contains the NXF family of shuttling transport receptors for nuclear export of mRNA, which include: The Tap-C domain is made of four alpha helices packed against each other. The arrangement of helices 1, 2 and 3 is similar to that seen in a UBA fold . and

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