33-511: [REDACTED] Look up nemo in Wiktionary, the free dictionary. Nemo may refer to: Arts, entertainment and media [ edit ] Games [ edit ] Nemo (arcade game) , a 1990 arcade game by Capcom based on Little Nemo NEMO (video game console) , an unreleased console Music [ edit ] Nemo (American band) , an indie rock band Nemo (Belgian band) ,
66-409: A defunct Australian motor racing team (1999–2012) Science and technology [ edit ] Physics and computing [ edit ] Nemo (file manager) , a file manager for Linux distributions forked from Nautilus NEMO , an Australian open source electricity system model NEMO (Stellar Dynamics Toolbox) , a toolbox for stellar dynamics modeling Neutrino Ettore Majorana Observatory ,
99-409: A defunct Australian motor racing team (1999–2012) Science and technology [ edit ] Physics and computing [ edit ] Nemo (file manager) , a file manager for Linux distributions forked from Nautilus NEMO , an Australian open source electricity system model NEMO (Stellar Dynamics Toolbox) , a toolbox for stellar dynamics modeling Neutrino Ettore Majorana Observatory ,
132-1082: A former French rocket launch pad off the Riviera coast NeMO, a NASA project for the Next Mars Orbiter People and fictional characters [ edit ] Nemo (name) , a list of people and fictional characters with the given name, nickname or surname Constantin de Grimm , illustrator of Vanity Fair caricatures under the name "Nemo" Nemo Ramjet, pen name of C. M. Kosemen (born 1984), Turkish artist and author Places [ edit ] Antarctica [ edit ] Nemo Cove , Pourquoi Pas Island, Graham Land Nemo Glacier , Pourquoi Pas Island, Graham Land Nemo Peak (Antarctica) , Wiencke Island, Palmer Archipelago United States [ edit ] Nemo, Missouri , an unincorporated community Nemo, South Dakota , an unincorporated community Nemo, Texas , an unincorporated community Elsewhere [ edit ] 1640 Nemo , an asteroid Mount Nemo (British Columbia) , in
165-951: A former French rocket launch pad off the Riviera coast NeMO, a NASA project for the Next Mars Orbiter People and fictional characters [ edit ] Nemo (name) , a list of people and fictional characters with the given name, nickname or surname Constantin de Grimm , illustrator of Vanity Fair caricatures under the name "Nemo" Nemo Ramjet, pen name of C. M. Kosemen (born 1984), Turkish artist and author Places [ edit ] Antarctica [ edit ] Nemo Cove , Pourquoi Pas Island, Graham Land Nemo Glacier , Pourquoi Pas Island, Graham Land Nemo Peak (Antarctica) , Wiencke Island, Palmer Archipelago United States [ edit ] Nemo, Missouri , an unincorporated community Nemo, South Dakota , an unincorporated community Nemo, Texas , an unincorporated community Elsewhere [ edit ] 1640 Nemo , an asteroid Mount Nemo (British Columbia) , in
198-689: A former rock band Nemo (French band) , a rock band Nemo (singer) , a Swiss singer "Nemo" (song) , by Nightwish from their album Once "Nemo", a song by Umphrey's McGee from their album Safety in Numbers NEMO Music Showcase and Conference , a former annual music event in Boston, Massachusetts Other uses in arts, entertainment and media [ edit ] For fictional characters, see Nemo (name) . Nemo (magazine) , devoted to classic comic strips Nemo (1984 film) , directed by Arnaud Sélignac Network for
231-555: A former rock band Nemo (French band) , a rock band Nemo (singer) , a Swiss singer "Nemo" (song) , by Nightwish from their album Once "Nemo", a song by Umphrey's McGee from their album Safety in Numbers NEMO Music Showcase and Conference , a former annual music event in Boston, Massachusetts Other uses in arts, entertainment and media [ edit ] For fictional characters, see Nemo (name) . Nemo (magazine) , devoted to classic comic strips Nemo (1984 film) , directed by Arnaud Sélignac Network for
264-506: A neutrino-related experiment in Modane, France Nucleus for European Modelling of the Ocean , a computational model of ocean circulation Nemo Mobile, a Linux mobile system originally based on Mer . Vehicles [ edit ] Citroën Nemo , a small truck Sisu Nemo , a motor Nemo , a remotely controlled underwater vehicle operated by Tommy Gregory Thompson DSV-5 Nemo ,
297-401: A neutrino-related experiment in Modane, France Nucleus for European Modelling of the Ocean , a computational model of ocean circulation Nemo Mobile, a Linux mobile system originally based on Mer . Vehicles [ edit ] Citroën Nemo , a small truck Sisu Nemo , a motor Nemo , a remotely controlled underwater vehicle operated by Tommy Gregory Thompson DSV-5 Nemo ,
330-530: A program studying human survival in an underwater laboratory Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Nemo . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Nemo&oldid=1226986591 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description
363-530: A program studying human survival in an underwater laboratory Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Nemo . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Nemo&oldid=1226986591 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description
SECTION 10
#1732773401717396-456: A role in preeclampsia and may offer insights into the genetic etiology of this condition. An increased level of NEMO gene expression was found in the blood of pregnant women with preeclampsia and their children. However, a decrease of the mRNA levels of total NEMO and the transcripts 1A, 1B, and 1C in placentas derived from preeclamptic women may be the main reason for intensified apoptosis. Sanger sequencing has indicated two distinct variations in
429-676: A submersible used by the United States Navy between 1970 and 1986 to oversee and observe undersea construction work. Other uses in science and technology [ edit ] IKBKG or NF-Kappa-B essential modulator (NEMO), a protein NEMO (museum) , a national science museum in Amsterdam Nemo link , a submarine power cable between the United Kingdom and Belgium, operational since January, 2019. Caisson Nemo ,
462-432: A submersible used by the United States Navy between 1970 and 1986 to oversee and observe undersea construction work. Other uses in science and technology [ edit ] IKBKG or NF-Kappa-B essential modulator (NEMO), a protein NEMO (museum) , a national science museum in Amsterdam Nemo link , a submarine power cable between the United Kingdom and Belgium, operational since January, 2019. Caisson Nemo ,
495-619: Is a protein that in humans is encoded by the IKBKG gene . NEMO is a subunit of the IκB kinase complex that activates NF-κB . The human gene for IKBKG is located on the chromosome band Xq28 . Multiple transcript variants encoding different isoforms have been found for this gene. NEMO (IKK-γ) is the regulatory subunit of the inhibitor of IκB kinase (IKK) complex, which activates NF-κB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in
528-505: Is a rare genetic condition relating to a fault in IKBKG. It mostly affects males and has a highly variable set of symptoms and prognoses. A drug called NEMO Binding Domain (NBD) has been designed to inhibit activation of NF-κB . NBD is a peptide that acts by binding to regulatory subunit NEMO (IKK-γ) thereby preventing it from binding subunits IKK-α and IKK-β and activating the IKK complex. In
561-567: Is different from Wikidata All article disambiguation pages All disambiguation pages nemo [REDACTED] Look up nemo in Wiktionary, the free dictionary. Nemo may refer to: Arts, entertainment and media [ edit ] Games [ edit ] Nemo (arcade game) , a 1990 arcade game by Capcom based on Little Nemo NEMO (video game console) , an unreleased console Music [ edit ] Nemo (American band) , an indie rock band Nemo (Belgian band) ,
594-620: Is different from Wikidata All article disambiguation pages All disambiguation pages IKBKG 2JVX , 2JVY , 3BRT , 3BRV , 3CL3 , 3FX0 , 4BWN , 5AAY 8517 16151 ENSG00000269335 ENSMUSG00000004221 Q9Y6K9 O88522 NM_001321397 NM_001377312 NM_001377313 NM_001377314 NM_001377315 NM_010547 NM_178590 NP_003630 NP_001364241 NP_001364242 NP_001364243 NP_001364244 NP_034677 NP_848705 NF-kappa-B essential modulator ( NEMO ) also known as inhibitor of nuclear factor kappa-B kinase subunit gamma (IKK-γ)
627-494: The 3’ UTR region of the NEMO gene in preeclamptic women (IKBKG:c.*368C>A and IKBKG:c.*402C>T). The occurrence of a maternal TT genotype and either a TT genotype in the daughter or T allele in the son increases the risk of preeclampsia by 2.59 fold. The configuration of those maternal and fetal genotypes (TT mother/TT daughter or TT mother/T son) is also associated with the level of NEMO gene expression. NEMO deficiency syndrome
660-573: The Establishment and Maintenance of Order, a fictional DC Comics organization created by the extraterrestrial Controllers Companies and organizations [ edit ] Saint Lucia National Emergency Management Organisation Nemo 33 , a diving center in Uccle, Belgium NEMO Equipment , Inc., a manufacturer of outdoor tents and shelters Nemo Rangers GAA , an Irish athletic club Paul Morris Motorsport , also known as Nemo Racing,
693-458: The Establishment and Maintenance of Order, a fictional DC Comics organization created by the extraterrestrial Controllers Companies and organizations [ edit ] Saint Lucia National Emergency Management Organisation Nemo 33 , a diving center in Uccle, Belgium NEMO Equipment , Inc., a manufacturer of outdoor tents and shelters Nemo Rangers GAA , an Irish athletic club Paul Morris Motorsport , also known as Nemo Racing,
SECTION 20
#1732773401717726-465: The IKBKG gene results in incontinentia pigmenti , hypohidrotic ectodermal dysplasia , and several other types of immunodeficiencies. Incontinentia Pigmenti (IP) is an X-linked dominant disease caused by a mutation in the IKBKG gene. Since IKBKG helps activate NF-κB, which protects cells against TNF-alpha induced apoptosis , a lack of IKBKG (and hence a lack of active NF-κB) makes cells more prone to apoptosis. Moreover, NEMO has been shown to play
759-566: The IKK-β subunit fused with a sequence derived from the Antennapedia homeodomain that mediates membrane translocation . Furthermore, wild type NBD peptide has been shown to dose-dependently inhibit interaction of IKKB with NEMO compared to mutant controls. Additionally, NF-κB activation was suppressed in HeLa cells after incubation with NBD wild type peptides. Moreover, to better understand
792-751: The Selkirk Mountains Mount Nemo, a crag in Mount Nemo Conservation Area , Ontario, Canada Nemo Peak , a volcano in the Kuril Islands Point Nemo , the place in the ocean that is farthest from land Other uses [ edit ] German submarine U-505 , a World War II submarine captured by the US and temporarily renamed USS Nemo Patria NEMO , a mortar system February 2013 nor'easter , also known as "Winter Storm Nemo" Nemo,
825-461: The Selkirk Mountains Mount Nemo, a crag in Mount Nemo Conservation Area , Ontario, Canada Nemo Peak , a volcano in the Kuril Islands Point Nemo , the place in the ocean that is farthest from land Other uses [ edit ] German submarine U-505 , a World War II submarine captured by the US and temporarily renamed USS Nemo Patria NEMO , a mortar system February 2013 nor'easter , also known as "Winter Storm Nemo" Nemo,
858-413: The absence of regulatory subunit IKK-γ the IKK complex is inactive, preventing the downstream signal transduction cascade leading to NF-κB activation. Binding of IKK-γ to IKK-α and IKK-β subunits activates the IKK complex leading to phosphorylation of IκB kinase , IκBα , and release of NF-κB dimers p105 and RELA to translocate to the nucleus and activate transcription of NF-κB responsive genes . In
891-472: The lowest survival rate compared to DLBCL subtypes, Germinal Center B-cell -like and Undefined Type 3 lymphoma, highlighting the great clinical need to define targets for cancer therapy. Notably, the NBD peptide targets the inflammation induced NF-κB activation pathway sparing the protective functions of basal NF-κB activity allowing for greater therapeutic value and fewer undesired side effects. The NBD peptide
924-597: The number of osteoclasts present in the joints of rheumatoid arthritic showed to be more prevalent in mice treated with PBS or the mutant NBD peptide compared to the NBD wild type peptide. Markedly, throughout the mouse model studies neither toxicity or lethality nor damage to kidneys or livers, was observed. Despite the potential for NBD peptide as a viable NF- κB inhibitory drug, disadvantages arise because of its peptide form. Peptides as drugs lack membrane permeability, are poorly orally viable, and generally have lower metabolic stability than small molecule drugs. Therefore,
957-496: The potential efficacy of the NBD peptide in suppressing inflammation, NBD peptide was tested on collagen induced rheumatoid arthritis mouse models. Notably, aberrant NF-κB activity is strongly associated with many aspects of the pathology of rheumatoid arthritis. Mice injected with wild-type NBD peptide showed only slightly visual signs of paw and joint swelling whereas mice injected with PBS or mutant NBD control peptides developed severe joint inflammation. Additionally, analysis of
990-539: The presence of the NBD peptide, the IKK complex remains inactive and IκBα sequesters NF-κB dimers in the cytoplasm inhibiting transcription of NF-κB responsive genes. While NF-κB inhibitory drugs have previously been attractive to disease such as chronic inflammation and diabetes , specific cancers have been shown to have constitutive NF-κB activity. Advanced B-cell lymphoma (ABC), a subtype of Diffuse large B-cell lymphoma (DLBCL) has been shown to have fundamental and upregulated NF-κB activity. ABC lymphoma also has
1023-666: The theoretical fourth part of the human psyche that emphasizes the self's insignificance and meaninglessness, used in The Aristos by John Fowles Nemo (dog) , French President Macron's dog Nemo A534 , a German Shepherd dog who served in the US Air Force during the Vietnam War Nearly but not fully Missing Out, a variant of fear of missing out See also [ edit ] Nimo (disambiguation) NEEMO (NASA Extreme Environment Mission Operations),
Nemo - Misplaced Pages Continue
1056-478: The theoretical fourth part of the human psyche that emphasizes the self's insignificance and meaninglessness, used in The Aristos by John Fowles Nemo (dog) , French President Macron's dog Nemo A534 , a German Shepherd dog who served in the US Air Force during the Vietnam War Nearly but not fully Missing Out, a variant of fear of missing out See also [ edit ] Nimo (disambiguation) NEEMO (NASA Extreme Environment Mission Operations),
1089-406: Was designed by identifying the amino acid binding sequence on IKK-α and IKK-β to which NEMO binds. A small region on the carboxyl terminus of IKK-α (L738-L743) and IKK-β (L737-L742) is essential for a stable interaction with NEMO and for the assembly of the active IKK complex. Henceforth this region is called the NEMO binding domain (NBD). The NBD peptide consists of the region from T735 to E745 of
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