The SRC Homology 3 Domain (or SH3 domain ) is a small protein domain of about 60 amino acid residues. Initially, SH3 was described as a conserved sequence in the viral adaptor protein v-Crk. This domain is also present in the molecules of phospholipase and several cytoplasmic tyrosine kinases such as Abl and Src . It has also been identified in several other protein families such as: PI3 Kinase , Ras GTPase-activating protein , CDC24 and cdc25 . SH3 domains are found in proteins of signaling pathways regulating the cytoskeleton , the Ras protein , and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases, SH3 proteins usually bind far away from the active site . Approximately 300 SH3 domains are found in proteins encoded in the human genome. In addition to that, the SH3 domain was responsible for controlling protein-protein interactions in the signal transduction pathways and regulating the interactions of proteins involved in the cytoplasmic signaling.
6-583: SH3 or SH-3 may refer to: SH3 domain , a protein structural domain thought to be involved in the formation of productive protein-protein binding interactions Renesas SH-3 , a member of the SuperH microprocessor family, used in mobile and hand-held devices Silent Hill 3 , the third installment in the Silent Hill survival horror video game series published by Konami Shadow Hearts: From The New World ,
12-641: A consensus sequence that can be represented as a regular expression or Short linear motif : with 1 and 4 being aliphatic amino acids, 2 and 5 always and 3 sometimes being proline. The sequence binds to the hydrophobic pocket of the SH3 domain. More recently, SH3 domains that bind to a core consensus motif R-x-x-K have been described. Examples are the C-terminal SH3 domains of adaptor proteins like Grb2 and Mona (a.k.a. Gads, Grap2, Grf40, GrpL etc.). Other SH3 binding motifs have emerged and are still emerging in
18-482: Is different from Wikidata All article disambiguation pages All disambiguation pages SH3 domain The SH3 domain has a characteristic beta-barrel fold that consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets . The linker regions may contain short helices. The SH3-type fold is an ancient fold found in eukaryotes as well as prokaryotes. The classical SH3 domain
24-430: Is usually found in proteins that interact with other proteins and mediate assembly of specific protein complexes, typically via binding to proline -rich peptides in their respective binding partner. Classical SH3 domains are restricted in humans to intracellular proteins, although the small human MIA family of extracellular proteins also contain a domain with an SH3-like fold. Many SH3-binding epitopes of proteins have
30-447: The same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=SH3&oldid=911016146 " Category : Letter–number combination disambiguation pages Hidden categories: Short description
36-650: The third game in the Shadow Hearts series. Silent Hunter III , a submarine simulation developed and published by Ubisoft. State Highway 3 , a common highway name in many countries Sikorsky SH-3 Sea King , also known as "Sikorsky S-61", a military helicopter produced by the United States Stronghold 3 a medieval castle-building simulation game from Firefly Studios . released on September 30, 2011. The sulfur analogue of hydronium (H 3 S) [REDACTED] Topics referred to by
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