1Y4E , 2BEC , 2E30 , 2KBV , 2L0E , 2MDF , 2YGG
4-492: 6548 20544 ENSG00000090020 ENSMUSG00000028854 P19634 Q61165 NM_003047 NM_016981 NM_001358455 NP_003038 NP_058677 NP_001345384 The sodium-hydrogen antiporter 1 ( NHE-1 ) also known as sodium/hydrogen exchanger 1 or SLC9A1 ( SoLute Carrier family 9A1 ) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene . The Na/H antiporter (SLC9A1)
8-399: Is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors , mitogens , neurotransmitters , tumor promoters , and others. Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II and CHP . It is also
12-844: The nephron of the kidney , specifically in the intercalary cells of the collecting duct and in the epithelial cells of the proximal convoluted tubule . The membrane pump is primarily responsible for maintaining homeostasis of pH and sodium. Defects in Na+/H+ antiporters may result in heart or kidney failure. Angiotensin II upregulates this antiporter in the proximal convoluted tubule in order to promote Na reabsorption and H secretion. Na+/H+ exchangers are thought to be implicated in other disorders such as hypertension. In one study, transgenic mice over expressing this membrane protein were shown to have increased reabsorption and retention of sodium after increased salt intake. In dopamine receptor signalling,
16-441: The target of the experimental drug rimeporide , which is being developed for the treatment of Duchenne muscular dystrophy . Sodium%E2%80%93hydrogen antiporter The sodium–hydrogen antiporter or sodium–proton exchanger ( Na+/H+ exchanger or NHX ) is a membrane protein that transports Na into the cell, and H out of the cell ( antiport ). They are found in the membranes of many cells, and especially in those of
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