In molecular biology , the sulfonylurea receptors ( SUR ) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells . More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels K ir 6.x ( 6.1 and 6.2 ). The association of four K ir 6.x and four SUR subunits form an ion conducting channel commonly referred to as the K ATP channel .
21-523: (Redirected from SUR ) [REDACTED] Look up sur or sûr in Wiktionary, the free dictionary. Sur , SUR or El Sur may refer to: Arts, entertainment and media [ edit ] Films [ edit ] Sur (film) , a 1988 Argentine film directed by Fernando Solanas Sur , a 1970 Mexican film directed by Gabriel Retes El Sur (film) 1983 film by Víctor Erice, based on
42-585: A 10th-century Hungarian general Science and technology [ edit ] Seemingly unrelated regressions (SUR), a statistical technique for analysing multivariate data Sulfonylurea receptor (SUR), the molecular target of sulfonylurea antidiabetic drugs Transport [ edit ] Summer Beaver Airport (IATA airport code: SUR), southwest of the First Nations community of Nibinamik, Ontario, Canada Surbiton railway station (National Rail station code SUR), London, England SS Sur ,
63-522: A 10th-century Hungarian general Science and technology [ edit ] Seemingly unrelated regressions (SUR), a statistical technique for analysing multivariate data Sulfonylurea receptor (SUR), the molecular target of sulfonylurea antidiabetic drugs Transport [ edit ] Summer Beaver Airport (IATA airport code: SUR), southwest of the First Nations community of Nibinamik, Ontario, Canada Surbiton railway station (National Rail station code SUR), London, England SS Sur ,
84-717: A Chilean newspaper Television [ edit ] Canal Sur , TV channel in Andalusia, Spain Telesur , a Latin-American TV channel Places [ edit ] Shur (Bible) or Sur, a wilderness from the Book of Exodus Sur (river) , a river in Bavaria, Germany Súr , a village in Hungary Sur, Diyarbakır , a district and municipality of Diyarbakır Province, Turkey Sur, Iran (disambiguation) Sur, Oman ,
105-443: A Chilean newspaper Television [ edit ] Canal Sur , TV channel in Andalusia, Spain Telesur , a Latin-American TV channel Places [ edit ] Shur (Bible) or Sur, a wilderness from the Book of Exodus Sur (river) , a river in Bavaria, Germany Súr , a village in Hungary Sur, Diyarbakır , a district and municipality of Diyarbakır Province, Turkey Sur, Iran (disambiguation) Sur, Oman ,
126-654: A Panamanian coaster in service 1955–65 Solapur railway station in Maharashtra, India Other uses [ edit ] Sur language , a minor Plateau language of Nigeria Soviet ruble (ISO 4217 code: SUR), the currency of the Soviet Union Sur offering , a burnt offering in Tibetan Buddhism Sur SC , a sports club based in Sur, Oman Sydney University Regiment , a regiment of
147-402: A Panamanian coaster in service 1955–65 Solapur railway station in Maharashtra, India Other uses [ edit ] Sur language , a minor Plateau language of Nigeria Soviet ruble (ISO 4217 code: SUR), the currency of the Soviet Union Sur offering , a burnt offering in Tibetan Buddhism Sur SC , a sports club based in Sur, Oman Sydney University Regiment , a regiment of
168-589: A town in Oman Sur, Switzerland , a village Sur State , a princely state of India merged with Idar State in 1821 Tyre, Lebanon (Arabic: Ṣūr ; Phoenician: Ṣur ; Turkish: Sur ), a city in Lebanon People [ edit ] Sur (Pashtun tribe) , a Pashtun tribe in Afghanistan, Pakistan and India Sur (poet) , a 16th-century blind Bhakti saint, poet and musician Súr (chieftain) ,
189-409: A town in Oman Sur, Switzerland , a village Sur State , a princely state of India merged with Idar State in 1821 Tyre, Lebanon (Arabic: Ṣūr ; Phoenician: Ṣur ; Turkish: Sur ), a city in Lebanon People [ edit ] Sur (Pashtun tribe) , a Pashtun tribe in Afghanistan, Pakistan and India Sur (poet) , a 16th-century blind Bhakti saint, poet and musician Súr (chieftain) ,
210-539: The Australian Army See also [ edit ] Big Sur (disambiguation) El Sur Ranch , California, US South (disambiguation) Suriname , a country Surr , a game played in India All pages with titles beginning with Sur All pages with titles containing Sur Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
231-411: The Australian Army See also [ edit ] Big Sur (disambiguation) El Sur Ranch , California, US South (disambiguation) Suriname , a country Surr , a game played in India All pages with titles beginning with Sur All pages with titles containing Sur Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
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#1732790785383252-621: The energy balance within the cell. Depending on the tissue in which the K ATP channel is expressed, altering the membrane potential can trigger a variety of downstream events. For example, in pancreatic beta cells , high levels of glucose lead to increased production of ATP, which, in turn, binds to the K ATP channel resulting in channel closure. The relative depolarization (decrease in membrane hyperpolarization ), in turn, opens voltage-dependent calcium channels increasing intracellular calcium concentrations, which triggers exocytosis of insulin . Under cerebral ischemic conditions, SUR1,
273-624: The film El Sur Music [ edit ] "Sur" (song) , a tango song composed by Homero Manzi and Aníbal Troilo Sur , a 1987 album by Uruguayan singer Jaime Roos Sur, a chapter in Sindhi music and poetry Svara (स्वर) or sur, the seven notes of the Indian musical scale Periodicals [ edit ] Sur (magazine) , former literary journal published in Buenos Aires, backed by Victoria Ocampo El Sur (newspaper) ,
294-458: The film El Sur Music [ edit ] "Sur" (song) , a tango song composed by Homero Manzi and Aníbal Troilo Sur , a 1987 album by Uruguayan singer Jaime Roos Sur, a chapter in Sindhi music and poetry Svara (स्वर) or sur, the seven notes of the Indian musical scale Periodicals [ edit ] Sur (magazine) , former literary journal published in Buenos Aires, backed by Victoria Ocampo El Sur (newspaper) ,
315-421: The 💕 [REDACTED] Look up sur or sûr in Wiktionary, the free dictionary. Sur , SUR or El Sur may refer to: Arts, entertainment and media [ edit ] Films [ edit ] Sur (film) , a 1988 Argentine film directed by Fernando Solanas Sur , a 1970 Mexican film directed by Gabriel Retes El Sur (film) 1983 film by Víctor Erice, based on
336-417: The novella by Adelaida García Morales Los Cuentos de Borges: El Sur (film) 1992 film by Carlos Saura Sur – The Melody of Life , a 2002 Indian film directed by Tanuja Chandra Literature [ edit ] "Sur" (short story) , a short story by Ursula K. Le Guin "El Sur" (story) ("The South"), a short story by Jorge Luis Borges El Sur , a novella by Adelaida García Morales , basis of
357-417: The novella by Adelaida García Morales Los Cuentos de Borges: El Sur (film) 1992 film by Carlos Saura Sur – The Melody of Life , a 2002 Indian film directed by Tanuja Chandra Literature [ edit ] "Sur" (short story) , a short story by Ursula K. Le Guin "El Sur" (story) ("The South"), a short story by Jorge Luis Borges El Sur , a novella by Adelaida García Morales , basis of
378-481: The regulatory subunit of the K ATP and the NC Ca-ATP channels, is expressed in neurons, astrocytes, oligodendrocytes, endothelial cells and by reactive microglia. Blockade of SUR1 receptors with glibenclamide has been involved in improved outcome in animal stroke models and investigational human studies by preventing brain swelling and enhancing neuroprotection. The isoforms of the sulfonylurea receptor have
399-462: The sulfonylurea receptor are known, SUR1 encoded by the ABCC8 gene, and SUR2A and SUR2B , which are splice variants arising from a single ABCC9 gene. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated K ir 6.x potassium channel. Hence, the K ATP channel monitors
420-482: The title Sur . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Sur&oldid=1254426738 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages sur From Misplaced Pages,
441-498: The title Sur . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Sur&oldid=1254426738 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Sulfonylurea receptor Three forms of
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