120-625: Robert Knox or Rob Knox may refer to: Robert Knox (surgeon) (1791–1862), Scottish surgeon, anatomist and zoologist Robert Knox (bishop) (1808–1893), Bishop of Down, Connor and Dromore and Archbishop of Armagh Robert Knox (sailor) (1641–1720), English sea captain in the service of the British East India Company Robert Knox (private equity investor) (born 1952) Robert Knox (fl. 1966), mayor of Berwick-upon-Tweed Robert C. Knox (1892–1947), justice of
240-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether
360-497: A polygenist ; however, some have argued that he was a monogenist , including biographer Alan Bates, who considers such claims to be "exaggerated." Robert Knox once wrote that he believed all human races to descend from an original ' Caucasian ' race. In his best-selling work, The Races of Men (1850), a "Zoological history" of mankind, Knox exaggerated supposed racial differences in support of his project, asserting that, anatomically and behaviourally, "race, or hereditary descent,
480-403: A skin rash . Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through
600-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but
720-409: A consciousness of the great epochs of time, of the fact of extinction, and of the inadequacy of the biblical account. From Étienne Geoffroy St-Hilaire and Henri Marie Ducrotay de Blainville , he gained a spatial and thematic perspective on living things. If one had the skill, all living beings could be arranged in their correct placing in a notional table, and one would see both internally and externally
840-605: A dissecting room at l' Hôpital de la Pitié . Knox returned to Edinburgh by Christmas 1822. On 1 December 1823 he was elected a Fellow of the Royal Society of Edinburgh . During these years he communicated a number of well-received papers to the Royal and Wernerian societies of Edinburgh on zoological subjects, including a paper suggesting that the " Hottentot " or "Bosjesman" Khoe and San people descended from " Mongolic " Chinese people. Soon after his election he submitted
960-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox
1080-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major
1200-444: A formality, but, at £250, an expensive one. At this time most professorships were in the gift of the town council, resulting in such uninspiring teachers as the professor of anatomy Alexander Monro , who put off many of his students (including the young Charles Darwin who took the course 1825–1827). This created a demand for private tuition, and the flamboyant Knox—in sole charge after Barclay's death in 1826—had more students than all
1320-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in
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#17327653037301440-577: A less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash) was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox,
1560-404: A lover of labour for labour's sake." Such supposed racial characteristics meant that each race was naturally fitted for a particular environment and could not endure outside it. While Knox maintained that all races were capable of some form of civilized life, he maintained that a vast gulf stood between the limited attainments available to the 'negroid' and to most 'mongoloid' races on one hand and
1680-524: A nephew). He found it impossible to find a university post, and from then until 1856 he worked on medical journalism, gave public lectures, and wrote several books, including his most ambitious work, The Races of Men in which he argued that each race was suited to its environment and "perfect in its own way." Additionally, Knox wrote a book on fishing in Scotland, which became his best-selling work. In 1854 his son Robert died of heart disease; Knox tried for
1800-612: A plan to the Royal College of Surgeons of Edinburgh for a Museum of Comparative Anatomy, which was accepted, and on 13 January 1825 he was appointed curator of the museum with a salary of £100. In 1825, John Barclay offered him a partnership at his anatomy school in Surgeon's Square, Edinburgh. In order for his lectures to be recognised by the Edinburgh College of Surgeons, Knox had to be admitted to its fellowship;
1920-663: A posting to the Crimea but at 63 was judged too old. In 1856 he became the pathological anatomist to the Free Cancer Hospital , London. He joined the medical register at its inception in 1858 and practiced obstetrics in Hackney. On 27 November 1860 he was elected an Honorary Fellow of the Ethnological Society of London, where he spoke in public for the last time on 1 July 1862. He continued working at
2040-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on
2160-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with
2280-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into
2400-409: A species. According to Richards, The Races of Men advocated "a common material origin of life and its evolution by a process of saltatory descent"; that is to say, new species arose not by gradual change but by sudden leaps due to shifts in embryonic development. Knox tentatively concluded that "simple animals ... may have produced by continuous generation the more complex animals of after ages . . .
2520-463: A student's certificate of attendance (not an uncommon practice in private schools) and refused to accept any further certificates from him, effectively banning him from teaching in Scotland. In the same year he was expelled from the Royal Society of Edinburgh and had his election retrospectively cancelled. Knox left for London after the death of his wife (the remaining children were left with
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#17327653037302640-619: A teacher of mathematics and natural philosophy at Heriot's Hospital in Edinburgh. As an infant, he contracted smallpox , which destroyed his left eye and disfigured his face. He was educated at the Royal High School of Edinburgh , where he was remembered as a 'bully' who thrashed his contemporaries "mentally and corporeally". He won the Lord Provost's gold medal in his final year. In 1810, he joined medical classes at
2760-440: A theory of saltatory evolution, in which "deformations" in embryonic development produced "hopeful monsters" that, if fortuitously suited to the prevailing environmental conditions, gave rise to new species in a single, macroevolutionary leap. In 1857 he wrote: "The conversion of one of these species into another cannot be so difficult a matter with Nature, especially when all or most of the specific characters are already present in
2880-592: A year under John Abernethy at St Bartholomew's Hospital in London . He was sent immediately to Belgium to attend the wounded from the Battle of Waterloo and returned two weeks later with the first batch of wounded aboard a hospital ship; during the voyage he successfully employed Abernethy's technique of leaving wounds open to the air. His army work at the Brussels military hospital (near Waterloo) impressed upon him
3000-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox
3120-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond
3240-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during
3360-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through
3480-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade
3600-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope
3720-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c. 1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in
Robert Knox - Misplaced Pages Continue
3840-465: Is everything." He offered crude characterisations of each racial group: for example the Saxon (in which race he included himself) "invents nothing", "has no musical ear", lacks "genius", and is so "low and boorish" that "he does not know what you mean by fine art." No race was without its redeeming features, however; Knox described Saxons as "[t]houghtful, plodding, industrious beyond all other races, [and]
3960-487: Is known of Knox's wife, Susan Knox, whom he married in 1824. According to Knox's friend Henry Lonsdale the marriage was kept secret as she was 'of inferior rank.' During his time in Edinburgh, Knox lived at 4 Newington Place with his sisters Mary and Jessie, while Susan and his four children lived at Lilliput Cottage in Trinity, west of Leith . They had seven children, but only two of them survived into adulthood. Before
4080-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had
4200-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in
4320-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this
4440-474: The 72nd Highlanders and sailed with them to South Africa . There were few army surgeons in the Cape Colony but Knox found the people healthy and his duties were light. He enjoyed riding, shooting and the beauty of the landscape with which he felt in spiritual harmony—an early expression of his transcendental world view. Knox developed an interest in observing racial types, and disapproved of what he saw as
4560-519: The Anatomy Act of 1832 widened the supply, the main legal supply of corpses for anatomical purposes in the UK were those condemned to death and dissection by the courts. This led to a chronic shortage of legitimate subjects for dissection, and this shortage became more serious as the need to train medical students grew, and the number of executions fell. In his school Knox ran up against the problem from
4680-419: The Anatomy Act 1832 and disagreements with professional colleagues ruined his career in Scotland. Following these developments, he moved to London , though this did not revive his career. Knox's views on humanity gradually shifted over the course of his lifetime, as his initially positive views (influenced by the ideals of Étienne Geoffroy Saint-Hilaire ) gave way to a more pessimistic view. Knox also devoted
4800-514: The Boers ' contempt for the indigenous peoples. However, after an abortive Xhosa rebellion against the colonial forces, he was involved in a retaliatory raid commanded by Andries Stockenström , a magistrate and future Lieutenant Governor. Relations with Stockenström were marred when Knox accused O. G. Stockenström, Andries' brother, of theft, a charge apparently prompted by ill feeling between British and Boer officers. A court martial acquitted O. G. of
4920-750: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where
Robert Knox - Misplaced Pages Continue
5040-558: The University of Edinburgh . He soon became interested in transcendentalism and the work of Xavier Bichat . He was twice president of the Royal Physical Society, an undergraduate club to which he presented papers on hydrophobia and nosology . The final recorded event of his university years was his just failing the anatomy examination. Knox joined the "extramural" anatomy class of the famous John Barclay . Barclay
5160-474: The West Port Murders , on 2 November 1828 Burke and Hare were caught, and the whole city convulsed with horror, fed by ballads, broadsides, and newspapers, at the reported deeds of the pair. Hare turned King's evidence , and Burke was hanged, dissected and his remains were displayed. Knox was not prosecuted, which outraged many in Edinburgh. His house was attacked by a mob of 'the lowest rabble of
5280-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that
5400-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of
5520-564: The smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after the disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It
5640-619: The "much maligned races" of the Cape against accusations of cannibalism, and to rebuke the Dutch for treating them like "wild beasts". From the perspective of a Lowland Scot Protestant, Knox's racist works espoused extreme racial hostility to Celts in general (including the Highland Scots and Welsh people , but particularly the Irish people ). Due to what he observed to be a prevalence of
5760-531: The "peculiar Mongol face" in many Highland Scots, Knox once suggested that he considered Highland Scots to descend from an early migration of "Mongol races". He considered the "Caledonian Celt" as touching "the end of his career: they are reduced to about one hundred and fifty thousand" and that the "Welsh Celts are not troublesome, but might easily become so." For Knox, "the Irish Celt is the most to be dreaded" and openly advocated their ethnic cleansing around
5880-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses
6000-459: The 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which
6120-504: The Arkansas Supreme Court Robert Sinclair Knox (1881–c. 1963), British Army officer Rob Knox (1989–2008), English actor Rob Knox (producer) (born 1980), American record producer and songwriter [REDACTED] Topics referred to by the same term This disambiguation page lists articles about people with the same name. If an internal link led you here, you may wish to change
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#17327653037306240-582: The Cancer Hospital until shortly before his death on 20 December 1862, at 9 Lambe Terrace in Hackney . He was buried at Brookwood Cemetery near Woking , Surrey. Knox's interest in race began as an undergraduate. His relevant political views were radical: he was an abolitionist and anti-colonialist who criticised the Boer as "the cruel oppressor of the dark races." Knox is generally considered to be
6360-779: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,
6480-543: The Old Town,' and windows were broken. A committee of the Royal Society of Edinburgh exonerated him on the grounds that he had not dealt personally with Burke and Hare, but there was no forgetting his part in the case, and many remained wary of him. Almost immediately after the Burke and Hare case, the Royal College of Surgeons of Edinburgh began to harry him, and by June 1831 they had procured his resignation as curator of
6600-452: The Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and the malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and
6720-833: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,
6840-565: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor
6960-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add
7080-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing
7200-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When
7320-424: The case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form, the prodromal illness still occurred but may have been less severe than in
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#17327653037307440-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate
7560-556: The charge and Andries called Knox's conduct shameful. One of Stockenström's supporters, a former naval officer named Burdett, challenged Knox to a duel. Knox initially refused to fight, and Burdett "soundly horse whipped him on the parade before every Officer of the Garrison." Knox then grabbed a sabre and inflicted a slight wound to Burdett's arm. Knox's promotion to Assistant Surgeon was cancelled and he returned to Britain in disgrace, arriving on Christmas Day 1820. He remained only until
7680-507: The clearing the land of all Papists and Jacobites ; this means Celts. If left to themselves, they would clear them out, as Cromwell proposed, by the sword; it would not require six weeks to accomplish the work. But the Encumbered Estates Relief Bill will do it better." In his writings Knox synthesised a perspective on nature from three of the most influential natural historians of his time. From Cuvier, he took
7800-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized
7920-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as
8040-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly
8160-436: The dissecting theatre by Knox, "dressed in an overgown and with bloody fingers", Audubon reported that "The sights were extremely disagreeable, many of them shocking beyond all I ever thought could be. I was glad to leave this charnel house and breathe again the salubrious atmosphere of the streets". Knox's school flourished and he took on three assistants, Alexander Miller, Thomas Wharton Jones and William Fergusson . Little
8280-400: The distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach the outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series,
8400-527: The elegant variation of their organs and anatomy according to the principles of connection, unity of composition and compensation. Goethe is another crucial addition to the Knoxian way of looking at nature. Goethe thought that there were transcendental archetypes in the living world which could be perceived by genus. If the natural historian were perspicacious enough to examine the creatures in this correct order he could perceive—aesthetically—the archetype that
8520-435: The first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by the second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By
8640-423: The first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and the temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on
8760-458: The fish of the early world may have produced reptiles, then again birds and quadrupeds; lastly, man himself?" Newly formed species survived or perished according to external conditions, which acted as "potent checks to an infinite variety of forms". For one contemporary reviewer, his claim that "Species is the product of external circumstances, acting through millions of years" was "bold, disgusting, and gratuitous atheism." In modern terms, he proposed
8880-486: The following October, after which he went to Paris to study anatomy for just over a year (1821–22). It was then that he met both Georges Cuvier and Étienne Geoffroy Saint-Hilaire , who were to remain his heroes for the rest of life, to populate his later medical journalism, and to become the subject of his hagiography , Great artists and great anatomists . While in Paris he befriended Thomas Hodgkin , with whom he shared
9000-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to
9120-478: The genus Orthopoxvirus . The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and
9240-465: The grave after burial, to stop it being violated. In November 1827, William Hare began a new career when an indebted lodger died on him by chance. He was paid £7.10s (seven pounds & ten shillings) for delivering the body to Knox's dissecting rooms at Surgeons' Square. Now Hare and, his friend and accomplice, William Burke, set about murdering the city’s poor on a regular basis. After 16 more transactions, each netting £8-10, in what later became known as
9360-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox
9480-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,
9600-464: The last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred a year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of
9720-464: The latter part of his career to studying and theorising on evolution and ethnology ; during this period, he also wrote numerous works advocating scientific racism . His work on the latter further harmed his legacy and overshadowed his contributions to evolutionary theory , which he used to account for racial differences. Robert Knox was born in 1791 in Edinburgh's North Richmond Street, the eighth child of Mary (née Scherer) and Robert Knox (d. 1812),
9840-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after
9960-461: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Robert_Knox&oldid=1252226870 " Category : Human name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Robert Knox (surgeon) Robert Knox FRSE FRCSE (4 September 1791 – 20 December 1862)
10080-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in
10200-452: The malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and the common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15,
10320-404: The mid-1830s. Knox continued to purchase cadavers for his dissection class from such shadowy figures as the 'Black Bull Man,' but after the 1832 Anatomy Act made bodies more available to all anatomists, he quarrelled with HM Inspector of Anatomy over the supply of bodies, and his competitive edge was lost. In 1837 Knox applied for the chair in pathology at Edinburgh University but his candidature
10440-442: The much greater past achievements and future potential of white men on the other. The Black, Knox remarked, "is no more a white man than an ass is a horse or a zebra." Ultimately however, all races were "[d]estined ... to run, like all other animals, a certain limited course of existence", it mattering "little how their extinction is brought about". In 1862 Knox took the opportunity of a second edition of The Races of Men to defend
10560-454: The museum he had proposed and founded. In the same year he was obliged to resign his army commission to avoid further service in the Cape. This removed his last source of guaranteed income, but fortunately his classes were more popular than ever, with a record 504 students. His school moved to the grander premises of Old Surgeons' Hall in 1833 but his class declined after Edinburgh University made its own practical anatomy class compulsory in
10680-558: The need for a comprehensive training in anatomy if surgery were to be successful. Knox was intelligent, critical and irritable. He did not suffer fools gladly and—in an aside with terrible consequences for his future career—he was critical of the surgical work of Charles Bell with casualties at the Battle of Waterloo. After a further trip to Belgium he was placed in charge of Hilsea hospital near Portsmouth , where he experimented with non-mercurial cures for syphilis. In April 1817, he joined
10800-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox
10920-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox
11040-416: The ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)
11160-483: The other private tutors put together. He turned his sharp wit on the elders and the clergy of the city, satirising religion and delighting his students. Knox routinely referred to the Bridgewater Treatises as the "bilgewater treatises" and his 'continental' lectures were not for the squeamish. John James Audubon was in Edinburgh at the time to find subscribers for his Birds of America . Shown round
11280-526: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of
11400-497: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because
11520-416: The pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced a discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on
11640-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before
11760-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this
11880-405: The sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to the touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week,
12000-481: The skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to the whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on
12120-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There
12240-491: The start, since—after 1815—the Royal Colleges had increased the anatomical work in the medical curriculum. If he taught according to what was known as 'French method' the ratio would have had to approach one corpse per pupil. As a consequence, body-snatching became so prevalent that it was not unusual for relatives and friends of someone who had just died to watch over the body until burial, and then to keep watch over
12360-588: The time that the Great Famine was happening, stating in The Races of Men: A Fragment (1850): "The source of all evil lies in the race, the Celtic race of Ireland. There is no getting over historical facts. Look at Wales, look at Caledonia; it is ever the same. [...] The race must be forced from the soil; by fair means, if possible; still they must leave. The Orange club of Ireland is a Saxon confederation for
12480-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on
12600-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox
12720-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in
12840-489: The young. Thus a given species may perish, but another of the same consanguinité takes its place in space: it is a question of time... Thus parenté extends from species to genus and from genus to class and order, in characters not to be misunderstood." Knox is commemorated in the scientific name of a species of African lizard, Meroles knoxii . Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to
12960-519: Was a Scottish anatomist and ethnologist best known for his involvement in the Burke and Hare murders . Born in Edinburgh , Scotland , Knox eventually partnered with anatomist and former teacher John Barclay and became a lecturer on anatomy in the city, where he introduced the theory of transcendental anatomy . However, Knox's incautious methods of obtaining cadavers for dissection before the passage of
13080-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of
13200-550: Was an anatomist of the highest distinction, and perhaps the greatest anatomical teacher in Britain at that time. Redoubling his efforts, Knox passed competently the second time around. Knox graduated from the University of Edinburgh in 1814, with a Latin thesis on the effects of narcotics which was published the following year. He joined the army and was commissioned Hospital Assistant on 24 June 1815, after having studied for
13320-479: Was blocked by eleven existing professors, who preferred to abolish the post rather than appoint him. In 1842 he was unable to make payments to the Edinburgh funeratory system, from which bodies were supplied to private schools, and he relocated to Glasgow where, still short of subjects for dissection, he closed his school in 1844. In 1847 the Royal College of Surgeons of Edinburgh found him guilty of falsifying
13440-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation
13560-405: Was immanent in the totality of a series, although present in none of them. Knox wrote that he was concerned to prove the existence of a generic animal, "or in other terms, proving hereditary descent to have a relation primarily to genus or natural family". This way, he could lay claim to a stability in the natural order at the level of the genus, but let species be extinguished. Man was a genus; not
13680-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from
13800-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox
13920-542: Was one of several diseases introduced by the Columbian exchange to the New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in
14040-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout
14160-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it
14280-516: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed
14400-401: Was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of the smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is
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