Chiral resolution , or enantiomeric resolution , is a process in stereochemistry for the separation of racemic mixture into their enantiomers . It is an important tool in the production of optically active compounds, including drugs . Another term with the same meaning is optical resolution .
36-482: (Redirected from Resolutions ) [REDACTED] Look up resolution or Resolving in Wiktionary, the free dictionary. Resolution(s) may refer to: Common meanings [ edit ] Resolution (debate) , the statement which is debated in policy debate Resolution (law) , a written motion adopted by a deliberative body New Year's resolution ,
72-584: A supersaturated solution of sodium ammonium tartrate with a d-crystal on one side of the reactor and a l-crystal on the opposite side, crystals of opposite handedness will form on the opposite sides of the reactor. Spontaneous resolution has also been demonstrated with racemic methadone . In a typical setup 50 grams dl-methadone is dissolved in petroleum ether and concentrated. Two millimeter-sized d- and l-crystals are added and after stirring for 125 hours at 40 °C two large d- and l-crystals are recovered in 50% yield. Another form of direct crystallization
108-423: A 2011 album by Dave Hause Resolution (EP) , a 2013 EP by Matt Corby Songs [ edit ] "Resolution" (Matt Corby song) , 2013 "Resolution" (Nick Lachey song) , a 2006 song by Nick Lachey from What's Left of Me "Resolution", a John Coltrane (1926–1967) song from A Love Supreme "Resolution", a Mahavishnu Orchestra song from the album Birds of Fire "Resolution", by Romantic Mode ,
144-423: A 2011 album by Dave Hause Resolution (EP) , a 2013 EP by Matt Corby Songs [ edit ] "Resolution" (Matt Corby song) , 2013 "Resolution" (Nick Lachey song) , a 2006 song by Nick Lachey from What's Left of Me "Resolution", a John Coltrane (1926–1967) song from A Love Supreme "Resolution", a Mahavishnu Orchestra song from the album Birds of Fire "Resolution", by Romantic Mode ,
180-662: A Western, sequel to Appaloosa Resolution (Wilson novel) , a 2016 work of historical fiction by A. N. Wilson Music [ edit ] Resolution (music) , the move of a note or chord from dissonance to consonance Albums [ edit ] Resolution (38 Special album) , 1997 Resolution (BoDeans album) , 2004 Resolution (Hamiet Bluiett album) , 1977 Resolution (Hidden in Plain View album) , 2007 Resolution (Lamb of God album) , 2012 Resolution (Andy Timmons album) , 2006 Resolution (Andy Pratt album) , 1976 Resolutions (album) ,
216-603: A Western, sequel to Appaloosa Resolution (Wilson novel) , a 2016 work of historical fiction by A. N. Wilson Music [ edit ] Resolution (music) , the move of a note or chord from dissonance to consonance Albums [ edit ] Resolution (38 Special album) , 1997 Resolution (BoDeans album) , 2004 Resolution (Hamiet Bluiett album) , 1977 Resolution (Hidden in Plain View album) , 2007 Resolution (Lamb of God album) , 2012 Resolution (Andy Timmons album) , 2006 Resolution (Andy Pratt album) , 1976 Resolutions (album) ,
252-567: A commitment that an individual makes at New Year's Day Dispute resolution , the settlement of a disagreement Science, technology, and mathematics [ edit ] Mathematics and logic [ edit ] Resolution (algebra) , an exact sequence in homological algebra Resolution (logic) , a rule of inference used for automated theorem proving Standard resolution , the bar construction of resolutions in homological algebra Resolution of singularities in algebraic geometry Measurements [ edit ] Resolution (audio) ,
288-683: A corporation Resolution (talent agency) , a talent agency in Los Angeles, New York, and Nashville Resolution Copper , a copper mining project near Superior, Arizona Resolution Foundation , an independent British think tank established in 2005 Resolution Limited , a Guernsey-based investor in insurance companies Resolution plc , a defunct manager of in-force UK life funds acquired by Pearl Group in 2008dabr Places [ edit ] Resolution, United States Virgin Islands Resolution Island (Nunavut) , in
324-544: A corporation Resolution (talent agency) , a talent agency in Los Angeles, New York, and Nashville Resolution Copper , a copper mining project near Superior, Arizona Resolution Foundation , an independent British think tank established in 2005 Resolution Limited , a Guernsey-based investor in insurance companies Resolution plc , a defunct manager of in-force UK life funds acquired by Pearl Group in 2008dabr Places [ edit ] Resolution, United States Virgin Islands Resolution Island (Nunavut) , in
360-399: A display device Graphic display resolutions , a list of particular display resolutions Distance resolution , the minimum distance that can be accurately measured Image resolution , a measure of the amount of detail in an image Optical resolution , the capability of an optical system to distinguish, find, or record details Printing resolution , the number of individual dots
396-399: A display device Graphic display resolutions , a list of particular display resolutions Distance resolution , the minimum distance that can be accurately measured Image resolution , a measure of the amount of detail in an image Optical resolution , the capability of an optical system to distinguish, find, or record details Printing resolution , the number of individual dots
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#1732771911400432-425: A measure of digital audio quality Resolution (electron density) , the quality of an X-ray crystallography or cryo-electron microscopy data set Angular resolution , the capability of an optical or other sensor to discern small objects Depositional resolution , the age difference of fossils contained in one stratum Display resolution , the number of distinct pixels in each dimension that can be displayed on
468-425: A measure of digital audio quality Resolution (electron density) , the quality of an X-ray crystallography or cryo-electron microscopy data set Angular resolution , the capability of an optical or other sensor to discern small objects Depositional resolution , the age difference of fossils contained in one stratum Display resolution , the number of distinct pixels in each dimension that can be displayed on
504-436: A printer can produce within a unit of distance (e.g., dots per inch ) Sensor resolution , the smallest change a sensor can detect in the quantity that it is measuring Spectral resolution , the capability of an optical system to distinguish different frequencies Resolution of a spectrometer , the ability to distinguish two close-lying energies (or wavelengths, or frequencies, or masses) Resolution (chromatography) ,
540-436: A printer can produce within a unit of distance (e.g., dots per inch ) Sensor resolution , the smallest change a sensor can detect in the quantity that it is measuring Spectral resolution , the capability of an optical system to distinguish different frequencies Resolution of a spectrometer , the ability to distinguish two close-lying energies (or wavelengths, or frequencies, or masses) Resolution (chromatography) ,
576-407: A process in stereochemistry for the separation of racemic compounds into their enantiomers URL resolution, a process in interpreting URLs Arts and entertainment [ edit ] Film and television [ edit ] "Resolutions" ( Star Trek: Voyager ) , a 1996 second-season episode of Star Trek: Voyager Resolution (film) , a 2012 horror movie "Resolution" ( Doctor Who ) ,
612-407: A process in stereochemistry for the separation of racemic compounds into their enantiomers URL resolution, a process in interpreting URLs Arts and entertainment [ edit ] Film and television [ edit ] "Resolutions" ( Star Trek: Voyager ) , a 1996 second-season episode of Star Trek: Voyager Resolution (film) , a 2012 horror movie "Resolution" ( Doctor Who ) ,
648-461: A special episode of Doctor Who Resolution (Boardwalk Empire) , an episode of the TV series Boardwalk Empire Literature and poetry [ edit ] Resolution (meter) , the replacement of one longum with two brevia "Resolution", a poem by Bertolt Brecht Resolutions (short story) , a 1911 short story by Franz Kafka Resolution (Parker novel) , a 2008 novel by Robert B. Parker,
684-413: A special episode of Doctor Who Resolution (Boardwalk Empire) , an episode of the TV series Boardwalk Empire Literature and poetry [ edit ] Resolution (meter) , the replacement of one longum with two brevia "Resolution", a poem by Bertolt Brecht Resolutions (short story) , a 1911 short story by Franz Kafka Resolution (Parker novel) , a 2008 novel by Robert B. Parker,
720-411: Is dissolved in a mixture of toluene and methanol to which solution is added optically active (S)- mandelic acid 3 . The alcohol (S)-enantiomer forms an insoluble diastereomeric salt with the mandelic acid and can be filtered from the solution. Simple deprotonation with sodium hydroxide liberates free (S)-alcohol. In the meanwhile the (R)-alcohol remains in solution unaffected and is recycled back to
756-945: The Arctic region of Canada Resolution Island, New Zealand , the largest (uninhabited) island in Fiordland, in the southwest of New Zealand Resolution Island, a fictional island in the novel Brown on Resolution Fort Resolution , a hamlet in the South Slave Region of the Northwest Territories, Canada Vessels [ edit ] Resolution , a Douglas DC-6 aircraft, BCPA Flight 304 , which crashed near San Francisco in 1953 Resolution (1793 ship) , an American trading vessel whose crew were massacred in 1794 HMNZS Resolution , Royal New Zealand Navy surveillance ship HMS Resolution , any of several British Royal Navy ships TIV Resolution ,
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#1732771911400792-693: The Arctic region of Canada Resolution Island, New Zealand , the largest (uninhabited) island in Fiordland, in the southwest of New Zealand Resolution Island, a fictional island in the novel Brown on Resolution Fort Resolution , a hamlet in the South Slave Region of the Northwest Territories, Canada Vessels [ edit ] Resolution , a Douglas DC-6 aircraft, BCPA Flight 304 , which crashed near San Francisco in 1953 Resolution (1793 ship) , an American trading vessel whose crew were massacred in 1794 HMNZS Resolution , Royal New Zealand Navy surveillance ship HMS Resolution , any of several British Royal Navy ships TIV Resolution ,
828-499: The disadvantage of necessarily discarding at least half of the starting racemic mixture. Asymmetric synthesis of one of the enantiomers is one means of avoiding this waste. The most common method for chiral resolution involves conversion of the racemic mixture to a pair of diastereomeric derivatives by reacting them with chiral derivatizing agents , also known as chiral resolving agents . The derivatives which are then separated by conventional crystallization, and converted back to
864-451: The enantiomers by removal of the resolving agent. The process can be laborious and depends on the divergent solubilities of the diastereomers, which is difficult to predict. Often the less soluble diastereomer is targeted and the other is discarded or racemized for reuse. It is common to test several resolving agents. Typical derivatization involves salt formation between an amine and a carboxylic acid . Simple deprotonation then yields back
900-453: The 💕 [REDACTED] Look up resolution or Resolving in Wiktionary, the free dictionary. Resolution(s) may refer to: Common meanings [ edit ] Resolution (debate) , the statement which is debated in policy debate Resolution (law) , a written motion adopted by a deliberative body New Year's resolution , a commitment that an individual makes at New Year's Day Dispute resolution ,
936-416: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Resolution&oldid=1242496321 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages resolution From Misplaced Pages,
972-483: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Resolution&oldid=1242496321 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Chiral resolution The use of chiral resolution to obtain enantiomerically pure compounds has
1008-400: The pure enantiomer. Examples of chiral derivatizing agents are tartaric acid and the amine brucine . The method was introduced (again) by Louis Pasteur in 1853 by resolving racemic tartaric acid with optically active (+)- cinchotoxine . One modern-day method of chiral resolution is used in the organic synthesis of the drug duloxetine : In one of its steps the racemic alcohol 1
1044-619: The racemic mixture by epimerization with hydrochloric acid in toluene. This process is known as RRR synthesis in which the R's stand for Resolution-Racemization-Recycle . The chiral pool consists of many widely available resolving agents. Via the process known as spontaneous resolution , 5-10% of all racemates crystallize as mixtures of enantiopure crystals. This phenomenon allowed Louis Pasteur to separate left-handed and right-handed sodium ammonium tartrate crystals. These experiments underpinned his discovery of optical activity . In 1882 he went on to demonstrate that by seeding
1080-421: The second opening theme for the anime After War Gundam X "Resolution", by Haruka Tomatsu , the first opening theme for the anime Sword Art Online: Alicization War of Underworld "The Resolution", a 2008 Jack's Mannequin song from The Glass Passenger Business and organizations [ edit ] Corporate resolution , a legal document defining which individuals are authorized to act on behalf of
1116-421: The second opening theme for the anime After War Gundam X "Resolution", by Haruka Tomatsu , the first opening theme for the anime Sword Art Online: Alicization War of Underworld "The Resolution", a 2008 Jack's Mannequin song from The Glass Passenger Business and organizations [ edit ] Corporate resolution , a legal document defining which individuals are authorized to act on behalf of
Resolution - Misplaced Pages Continue
1152-504: The separation of peaks in a chromatogram Resolution (mass spectrometry) , the ability to distinguish peaks in a mass spectrum Spatial resolution , the pixel width on the ground Temporal resolution , the sampling frequency of a digital audio device In number storage, the resolution is the reciprocal of the unit in the last place Other uses in science and technology [ edit ] Resolution (beam engine) , an early steam engine at Coalbrookdale Chiral resolution ,
1188-504: The separation of peaks in a chromatogram Resolution (mass spectrometry) , the ability to distinguish peaks in a mass spectrum Spatial resolution , the pixel width on the ground Temporal resolution , the sampling frequency of a digital audio device In number storage, the resolution is the reciprocal of the unit in the last place Other uses in science and technology [ edit ] Resolution (beam engine) , an early steam engine at Coalbrookdale Chiral resolution ,
1224-486: The settlement of a disagreement Science, technology, and mathematics [ edit ] Mathematics and logic [ edit ] Resolution (algebra) , an exact sequence in homological algebra Resolution (logic) , a rule of inference used for automated theorem proving Standard resolution , the bar construction of resolutions in homological algebra Resolution of singularities in algebraic geometry Measurements [ edit ] Resolution (audio) ,
1260-611: The world's first turbine installation vessel Resolution -class submarine , of the British Royal Navy Resolution (1802 ship) , a brig built in Spain and launched in 1802 See also [ edit ] Resolve (disambiguation) Resolved (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Resolution . If an internal link led you here, you may wish to change
1296-475: The world's first turbine installation vessel Resolution -class submarine , of the British Royal Navy Resolution (1802 ship) , a brig built in Spain and launched in 1802 See also [ edit ] Resolve (disambiguation) Resolved (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Resolution . If an internal link led you here, you may wish to change
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