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58-426: (Redirected from Too Good To Be True ) Too Good to Be True may refer to: Film, television, and theatre [ edit ] Too Good to Be True (film) , a 1988 made-for-TV movie 2 Good 2 Be True , a 2022 Philippine family drama romantic comedy television series Too Good to Be True , a scrapped spin-off of TV series Small Wonder Too Good to Be True ,

116-539: A 1601 play by Wentworth Smith , Henry Chettle and Richard Hathwaye Too Good to Be True (TV series) , 2003 British drama thriller television series Too Good to Be True (2024 TV series) , 2024 British psychological thriller television series Albums [ edit ] Too Good to Be True (The Everly Brothers album) , 2005 Too Good to Be True (Rick Ross and Meek Mill album) , 2023 Songs [ edit ] "Too Good to Be True" (Clay Boland song) , 1936 "Too Good to Be True" (Danny Avila and

174-638: A common practice anymore, however, owing to the dangers of long-term use of barbiturates; they have been replaced by the benzodiazepines and Z-drug such as zolpidem, zaleplon and eszopiclone for sleep. The final class of barbiturates are known as long-acting barbiturates (the most notable one being phenobarbital, which has a half-life of roughly 92 hours). This class of barbiturates is used almost exclusively as anticonvulsants , although on rare occasions they are prescribed for daytime sedation. Barbiturates in this class are not used for insomnia, because, owing to their extremely long half-life, patients would awake with

232-420: A day or more, and subsequently result in bioaccumulation of the drug in the system. The therapeutic and recreational effects of long-acting barbiturates wear off significantly faster than the drug can be eliminated, allowing the drug to reach toxic concentrations in the blood following repeated administration (even when taken at the therapeutic or prescribed dose) despite the user feeling little or no effects from

290-480: A derivative of barbituric acid, or any salt of a derivative of barbituric acid" (all other barbiturates) were designated as being schedule III . Under the original CSA, no barbiturates were placed in schedule I, II, or V; however, amobarbital, pentobarbital, and secobarbital are now schedule II controlled substances unless they are in a suppository dosage form. In 1971, the Convention on Psychotropic Substances

348-683: A doctor, owing to the high lethality and relatively sudden onset of the withdrawal. Attempting to quit "cold turkey" may result in neurological damage due to excitotoxicity, severe physical injuries received during convulsions, and even death resulting from arrhythmias during grande Mal seizures, paralleling death caused by delirium tremens. Some symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgement, drowsiness, shallow breathing, staggering, and, in severe cases, coma or death. The lethal dosage of barbiturates varies greatly with tolerance and from one individual to another. The lethal dose

406-491: A manner similar to long-acting benzodiazepines such as diazepam and clonazepam . Often polysubstance use occurs and barbiturates are consumed with or substituted by other available substances, most commonly alcohol. People who use substances tend to prefer short-acting and intermediate-acting barbiturates. The most commonly used are amobarbital (Amytal), pentobarbital (Nembutal), and secobarbital (Seconal). A combination of amobarbital and secobarbital (called Tuinal )

464-401: A patient "under" in emergency surgery situations. Doctors can also bring a patient out of anesthesia just as quickly, should complications arise during surgery. The middle two classes of barbiturates are often combined under the title "short/intermediate-acting." These barbiturates are also employed for anesthetic purposes, and are also sometimes prescribed for anxiety or insomnia . This is not

522-499: A residual "hang-over" effect and feel groggy. Barbiturates can in most cases be used either as the free acid or as salts of sodium, calcium, potassium, magnesium, lithium, etc. Codeine - and dionine -based salts of barbituric acid have been developed. During World War II , military personnel in the Pacific region were given "goofballs" to improve their tolerance of the heat and humidity of daily working conditions. Goofballs reduced

580-505: Is also highly used. Short-acting and intermediate-acting barbiturates are usually prescribed as sedatives and sleeping pills. These pills begin acting fifteen to forty minutes after they are swallowed, and their effects last from five to six hours. Slang terms for barbiturates include barbs, barbies, bluebirds, dolls, wallbangers, yellows, downers, goofballs, sleepers, 'reds & blues', and tooties. (it lacks oxygen at #2 position of generic barbiturate structure) (the oxygen at #2 position

638-453: Is also taken with Richard and ends her engagement with Russell to be with Richard. Ellen convinces Richard to marry her, and they do so quickly. Ellen soon shows her dark side by becoming manipulative and jealous. At their lake house, she causes a rift between Richard and the long time caretaker by insinuating that he hit on her. She fires Danny's long time caregiver. When Margaret and Ruth visit, Richard talks to Ruth about using her artwork for

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696-415: Is an extended process often consisting of converting the patient to a long-acting benzodiazepine (i.e. Valium ), followed by slowly tapering off the benzodiazepine. Mental cravings for barbiturates can last for months or years in some cases and counselling/support groups are highly encouraged by addiction specialists. Patients should never try to tackle the task of discontinuing barbiturates without consulting

754-405: Is an ultra-short-acting barbiturate that is marketed under the name Sodium Pentothal. It is often mistaken for " truth serum ", or sodium amytal , an intermediate-acting barbiturate that is used for sedation and to treat insomnia, but was also used in so-called sodium amytal "interviews" where the person being questioned would incorrectly be thought to be more likely to provide the truth whilst under

812-424: Is associated with significant morbidity. One study found that 11% of males and 23% of females with a sedative - hypnotic misuse die by suicide. Other effects of barbiturate intoxication include drowsiness , lateral and vertical nystagmus , slurred speech and ataxia , decreased anxiety, and loss of inhibitions. Barbiturates are also used to alleviate the adverse or withdrawal effects of illicit drug use, in

870-404: Is considered one of the most dangerous withdrawals of any known addictive substance. Similarly to benzodiazepines, the longer acting barbiturates produce a less severe withdrawal syndrome than short acting and ultra-short acting barbiturates. Withdrawal symptoms are dose-dependent with heavier users being more affected than lower-dose addicts. The pharmacological treatment of barbiturate withdrawal

928-423: Is going to New York for a few days. Beside herself, Ellen begins plotting revenge. Ellen tells Ruth about the sleepless nights and nightmares she has been having and asks Ruth for her prescription barbiturate sleeping pills. Ruth goes to get them for her, and Ellen looks through her purse and finds a plane ticket to New York. Ellen opens all of the capsules and dumps the powder into a sweetener packet and then puts

986-420: Is highly variable among different members of the class, with superpotent barbiturates such as pentobarbital being potentially fatal in considerably lower doses than the low-potency barbiturates such as butalbital. Even in inpatient settings, the development of tolerance is still a problem, as dangerous and unpleasant withdrawal symptoms can result when the drug is stopped after dependence has developed. Tolerance to

1044-413: Is missing. Ellen ends up dying, and although initially classified as a suicide, Ruth is arrested and put on trial for murder. The district attorney is Ellen's ex-fiancé, Russell and he presents evidence that Ruth was jealous of Ellen and that Ellen sent him a letter mentioning Ruth trying to kill her. Margaret finds the swapped out sweetener packet and powder residue in the pocket of the jacket Ellen wore at

1102-429: Is somewhat more complex than telling the truth, especially under the influence of a sedative-hypnotic drug. The memory-impairing effects and cognitive impairments induced by sodium thiopental are thought to reduce a subject's ability to invent and remember lies. This practice is no longer considered legally admissible in court, owing to findings that subjects undergoing such interrogations may form false memories, putting

1160-417: Is specifically exempted from controlled substance status, while its sibling Fiorinal , which contains aspirin instead of paracetamol and may contain codeine phosphate, remains a schedule III drug. Recreational users report that a barbiturate high gives them feelings of relaxed contentment and euphoria . Physical and psychological dependence may also develop with repeated use. Chronic misuse of barbiturates

1218-629: Is the principal excitatory neurotransmitter in the mammalian CNS. Taken together, the findings that barbiturates potentiate inhibitory GABA A receptors and inhibit excitatory AMPA receptors can explain the superior CNS-depressant effects of these agents to alternative GABA potentiating agents such as benzodiazepines and quinazolinones . At higher concentration, they inhibit the Ca -dependent release of neurotransmitters such as glutamate via an effect on P / Q-type voltage-dependent calcium channels . Barbiturates produce their pharmacological effects by increasing

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1276-568: The 1970s most barbiturates were replaced by benzodiazepines . Barbituric acid itself does not have any direct effect on the central nervous system and chemists have derived over 2,500 compounds from it that possess pharmacologically active qualities. The broad class of barbiturates is further broken down and classified according to speed of onset and duration of action. Ultrashort-acting barbiturates are commonly used for anesthesia because their extremely short duration of action allows for greater control. These properties allow doctors to rapidly put

1334-492: The GABA A receptor at multiple homologous transmembrane pockets located at subunit interfaces, which are binding sites distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. In addition to this GABAergic effect, barbiturates also block AMPA and kainate receptors , subtypes of ionotropic glutamate receptor . Glutamate

1392-665: The GABA A receptor channel is only one of several representatives. This Cys-loop receptor superfamily of ion channels includes the neuronal nACh receptor channel, the 5-HT 3 receptor channel, and the glycine receptor channel. However, while GABA A receptor currents are increased by barbiturates (and other general anesthetics), ligand-gated ion channels that are predominantly permeable for cationic ions are blocked by these compounds. For example, neuronal nAChR channels are blocked by clinically relevant anesthetic concentrations of both thiopental and pentobarbital. Such findings implicate (non-GABA-ergic) ligand-gated ion channels, e.g.

1450-583: The Vamps song) , 2018 "Too Good to Be True" (Edens Edge song) , 2012 "Too Good to Be True" (Michael Peterson song) , 1998 "Too Good to Be True" by Motörhead from March ör Die , 1992 "Too Good to Be True", song by Tom Robinson Band on the 1978 album Power in the Darkness See also [ edit ] Too Good (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with

1508-617: The anxiolytic and sedative effects of barbiturates tends to develop faster than tolerance to their effects on smooth muscle, respiration, and heart rate, making them generally unsuitable for a long time psychiatric use. Tolerance to the anticonvulsant effects tends to correlate more with tolerance to physiological effects, however, meaning that they are still a viable option for long-term epilepsy treatment. Barbiturates in overdose with other CNS (central nervous system) depressants (e.g. alcohol, opiates, benzodiazepines) are even more dangerous owing to additive CNS and respiratory depressant effects. In

1566-417: The baby, not her. Ellen sees her doctor and tells her she wants an abortion and she has not discussed it with Richard. The doctor, who also a friend of Richard's says she cannot perform the abortion and be expected to keep it a secret from Richard, telling Ellen she'll have to go somewhere else. Ellen sneaks out of the house and goes to the lake house, where she stages her "accidental" fall, causing her to lose

1624-429: The baby. Richard, who has begun spending more time with Ruth, admits to her that he thinks Ellen losing the baby was for the best, and that he plans on leaving her because he does not love her anymore, and was only staying with her because of the baby. Ellen makes the connection that Richard is involved with Ruth when she sees the cover of his new book, with Ruth's art. Richard tells her they need some time apart and that he

1682-434: The basic structure, mainly in position 5 on the ring. In modern chemistry the barbiturates are often presented by its Hirshfeld surface representations showing its intermolecular interactions [1] calculated with CrystalExplorer Program. Sodium barbital and barbital have also been used as pH buffers for biological research, e.g., in immuno-electrophoresis or in fixative solutions. Barbiturates are classified based on

1740-418: The capsules back together, filling them with talcum powder . At Ellen's birthday party, she asks Richard to talk to her privately in another room, and she alludes to knowing what is going on between him and Ruth. As they argue, he confronts her about Danny's death. She admits to letting him drown because Richard paid more attention to Danny, than to her. Richard hits her causing her to fall, and he storms out of

1798-496: The case of benzodiazepines, not only do they have additive effects, barbiturates also increase the binding affinity of the benzodiazepine binding site, leading to exaggerated benzodiazepine effects. (ex. If a benzodiazepine increases the frequency of channel opening by 300%, and a barbiturate increases the duration of their opening by 300%, then the combined effects of the drugs increases the channels' overall function by 900%, not 600%). The longest-acting barbiturates have half-lives of

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1856-592: The class possess relevant enzyme induction capabilities, the degree of induction overall as well as the impact on each specific enzyme span a broad range, with phenobarbital and secobarbital being the most potent enzyme inducers and butalbital and talbutal being among the weakest enzyme inducers in the class. People who are known to have killed themselves by barbiturate overdose include Stefan Zweig , Charles Boyer , Ruan Lingyu , Dalida , Jeannine Deckers , Felix Hausdorff , Abbie Hoffman , Phyllis Hyman , C. P. Ramanujam , George Sanders , Jean Seberg , Lupe Vélez and

1914-466: The consequences of barbiturate withdrawal (she was hospitalized with burns, the doctors treating her not being aware of her barbiturate addiction). The use of Barbiturates is contraindicated in the following conditions: Barbiturates act as positive allosteric modulators and, at higher doses, as agonists of GABA A receptors . GABA is the principal inhibitory neurotransmitter in the mammalian central nervous system (CNS). Barbiturates bind to

1972-413: The cover of his upcoming book causing Ellen to have a fit. Ellen has been teaching Danny how to do distance swimming to the buoys while she sits in a row boat. One day, Danny complains of a cramp and Ellen ignores his pleas for help. Richard, inside working, hears Danny's screams for help and rushes out onto the water in a speed boat. Ellen pretends to try and help look for him as they both repeatedly dive in

2030-569: The demand on the respiratory system, as well as maintaining blood pressure. Many soldiers returned with addictions that required several months of rehabilitation before discharge. This led to growing dependency problems, often exacerbated by indifferent physicians prescribing high doses to unknowing patients through the 1950s and 1960s. In the late 1950s and 1960s, an increasing number of published reports of barbiturate overdoses and dependence problems led physicians to reduce their prescription, particularly for spurious requests. This eventually led to

2088-403: The drug passes through the placenta to the fetus. After the baby is born, it may experience withdrawal symptoms and have trouble breathing. In addition, nursing mothers who take barbiturates may transmit the drug to their babies through breast milk. A rare adverse reaction to barbiturates is Stevens–Johnson syndrome , which primarily affects the mucous membranes. With regular use, tolerance to

2146-489: The duration of action. Examples of each class include: Indications for the use of barbiturates include: There are special risks to consider for older adults, and women who are pregnant. When a person ages, the body becomes less able to rid itself of barbiturates. As a result, people over the age of sixty-five are at higher risk of experiencing the harmful effects of barbiturates, including drug dependence and accidental overdose. When barbiturates are taken during pregnancy,

2204-640: The duration of chloride ion channel opening at the GABA A receptor (pharmacodynamics: This increases the efficacy of GABA), whereas benzodiazepines increase the frequency of the chloride ion channel opening at the GABA A receptor (pharmacodynamics: This increases the potency of GABA). The direct gating or opening of the chloride ion channel is the reason for the increased toxicity of barbiturates compared to benzodiazepines in overdose. Further, barbiturates are relatively non-selective compounds that bind to an entire superfamily of ligand-gated ion channels, of which

2262-448: The effects of barbiturates develops. Research shows tolerance can develop with even one administration of a barbiturate. As with all GABAergic drugs, barbiturate withdrawal produces potentially fatal effects such as seizures, in a manner reminiscent of delirium tremens and benzodiazepine withdrawal although its more direct mechanism of GABA agonism makes barbiturate withdrawal even more severe than that of alcohol or benzodiazepines. It

2320-444: The house. Ruth and Margaret come in to console her, and Ruth stirs the sweetener, that is really the sleeping pill powder placed there by Ellen, into iced tea that Ellen drinks. Later that same day, Ruth is packing for her trip, she hears Ellen calling out to her and asks her to call the hospital, telling her she took sleeping pills. Ruth believes she is faking it and goes and counts the sleeping pills she gave Ruth, seeing that only one

2378-432: The influence of the drug. When dissolved in water, sodium amytal can be swallowed, or it can be administered by intravenous injection. The drug does not itself force people to tell the truth, but is thought to decrease inhibitions and slow creative thinking, making subjects more likely to be caught off guard when questioned, and increasing the possibility of the subject revealing information through emotional outbursts. Lying

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2436-497: The latter are less toxic in drug overdose . However, barbiturates are still used as anticonvulsants (e.g., phenobarbital and primidone ) and general anesthetics (e.g., sodium thiopental ). Barbiturates in high doses are used for medical aid in dying , and in combination with a muscle relaxant for euthanasia and for capital punishment by lethal injection . Barbiturates are frequently employed as euthanizing agents in small-animal veterinary medicine . Sodium thiopental

2494-614: The members of Heaven's Gate cult. Others who have died as a result of barbiturate overdose include Pier Angeli , Brian Epstein , Judy Garland , Jimi Hendrix , Marilyn Monroe , Inger Stevens , Dinah Washington , Ellen Wilkinson , and Alan Wilson ; in some cases these have been speculated to be suicides as well. Those who died of a combination of barbiturates and other drugs include Rainer Werner Fassbinder , Dorothy Kilgallen , Malcolm Lowry , Edie Sedgwick and Kenneth Williams . Dorothy Dandridge died of either an overdose or an unrelated embolism . Ingeborg Bachmann may have died of

2552-465: The neuronal nAChR channel, in mediating some of the (side) effects of barbiturates. This is the mechanism responsible for the (mild to moderate) anesthetic effect of barbiturates in high doses when used in anesthetic concentration. Drug interactions with barbiturates are: Caution is needed in people using: Caution is also required in patients with: Barbituric acid was first synthesized 27 November 1864, by German chemist Adolf von Baeyer . This

2610-411: The new substance by amalgamating Barbara with urea . Another story holds that Baeyer synthesized the substance from the collected urine of a Munich waitress named Barbara. No substance of medical value was discovered, however, until 1903 when two German scientists working at Bayer , Emil Fischer and Joseph von Mering , discovered that barbital was very effective in putting dogs to sleep. Barbital

2668-651: The party. Testing concludes that Ellen tried to stage her own murder, and the charges against Ruth are dropped. Richard and Ruth are seen at the lake house together. Barbiturate Barbiturates are a class of depressant drugs that are chemically derived from barbituric acid . They are effective when used medically as anxiolytics , hypnotics , and anticonvulsants , but have physical and psychological addiction potential as well as overdose potential among other possible adverse effects. They have been used recreationally for their anti-anxiety and sedative effects, and are thus controlled in most countries due to

2726-837: The patients name, and have to contain the name and initials, address, city and telephone number of the licensed prescriber issuing the prescriptions, as well as the name and initials, address and city of the person the prescription is issued to). Among that group of drugs are the barbiturates amobarbital , butalbital , cyclobarbital , and pentobarbital . In the United States, the Controlled Substances Act of 1970 classified most barbiturates as controlled substances—and they remain so as of August 2023 . Barbital , methylphenobarbital (also known as mephobarbital ), and phenobarbital are designated schedule IV drugs, and "Any substance which contains any quantity of

2784-740: The plasma-bound concentrations of the drug. Users who consume alcohol or other sedatives after the drug's effects have worn off, but before it has cleared the system, may experience a greatly exaggerated effect from the other sedatives which can be incapacitating or even fatal. Barbiturates induce a number of hepatic CYP enzymes (most notably CYP2C9 , CYP2C19 , and CYP3A4 ), leading to exaggerated effects from many prodrugs and decreased effects from drugs which are metabolized by these enzymes to inactive metabolites. This can result in fatal overdoses from drugs such as codeine , tramadol , and carisoprodol , which become considerably more potent after being metabolized by CYP enzymes. Although all known members of

2842-478: The reliability of all information obtained through such methods into question. Nonetheless, it is still employed in certain circumstances by defense and law enforcement agencies as a "humane" alternative to torture interrogation when the subject is believed to have information critical to the security of the state or agency employing the tactic. In 1988, the synthesis and binding studies of an artificial receptor binding barbiturates by six complementary hydrogen bonds

2900-881: The risks associated with such use. Barbiturates have largely been replaced by benzodiazepines and nonbenzodiazepines ("Z-drugs") in routine medical practice, particularly in the treatment of anxiety disorders and insomnia , because of the significantly lower risk of overdose, and the lack of an antidote for barbiturate overdose . Despite this, barbiturates are still in use for various purposes: in general anesthesia , epilepsy , treatment of acute migraines or cluster headaches , acute tension headaches , euthanasia , capital punishment , and assisted suicide . Barbiturates, such as phenobarbital , were long used as anxiolytics and hypnotics . Intermediate-acting barbiturates reduce time to fall asleep, increase total sleep time, and reduce REM sleep time. Today they have been largely replaced by benzodiazepines for these purposes because

2958-530: The scheduling of barbiturates as controlled drugs. In the Netherlands, the Opium Law classifies all barbiturates as List II drugs, with the exception of secobarbital , which is on List I . There is a small group of List II drugs for which physicians have to write the prescriptions according to the same, tougher guidelines as those for List I drugs (writing the prescription in full in letters, listing

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3016-430: The summer. Richard is a widower whose wife was killed in a car accident that crippled Danny. When they arrive, a beautiful woman, Ellen Berent, catches Richard's eye and it is revealed that she is also staying at Glen's with her mother, Margaret, and sister, Ruth. Glen tries to dissuade Richard from pursuing Ellen by mentioning her engagement to Russell Quinton, but a smitten Richard tells him to mind his own business. Ellen

3074-583: The title Too Good to Be True . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Too_Good_to_Be_True&oldid=1257834339 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Too Good to Be True (film) Richard Harland an author, and his son, Danny, are visiting Richard's attorney and friend, Glen for

3132-409: The water, but it is too late, and Danny drowns. Richard becomes more withdrawn from Ellen and begins sleeping in a guest bedroom at their house. Ellen panics as she loses her grip on Richard, and she goes in the guest room and wakes him up and they have sex. Ellen announces she is pregnant and they seem happy for a little while. Ellen tells Ruth she hates being pregnant and that Richard only cares about

3190-404: Was done by condensing urea with diethyl malonate . There are several stories about how the substance got its name. The most likely story is that Baeyer and his colleagues went to celebrate their discovery in a tavern where the town's artillery garrison were also celebrating the feast of Saint Barbara  – the patron saint of artillerymen. An artillery officer is said to have christened

3248-430: Was published. Since this first article, different kind of receptors were designed, as well as different barbiturates and cyanurates , not for their efficiencies as drugs but for applications in supramolecular chemistry , in the conception of materials and molecular devices. The preferred IUPAC name of the base compound, barbituric acid, is 1,3-diazinane-2,4,6-trione. Different barbiturates have different substituents in

3306-601: Was signed in Vienna . Designed to regulate amphetamines , barbiturates, and other synthetics, the 34th version of the treaty , as of 25 January 2014 , regulates secobarbital as schedule II, amobarbital, butalbital, cyclobarbital, and pentobarbital as schedule III, and allobarbital , barbital , butobarbital , mephobarbital , phenobarbital , butabarbital , and vinylbital as schedule IV on its "Green List". The combination medication Fioricet , consisting of butalbital, caffeine, and paracetamol (acetaminophen), however,

3364-511: Was then marketed by Bayer under the trade name Veronal . It is said that Mering proposed this name because the most peaceful place he knew was the Italian city of Verona . In 1912, Bayer introduced another barbituric acid derivative, phenobarbital , under the trade name Luminal, as a sedative – hypnotic . It was not until the 1950s that the behavioral disturbances and physical dependence potential of barbiturates became recognized. Since

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