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78-597: The Umeda Sky Building ( 梅田スカイビル , Umeda Sukai Biru ) is a two-tower mixed-use skyscraper located in Osaka , Japan . Located in the outskirts of Umeda business district in Kita-ku, Osaka , the Umeda Sky Building consists of two 40-story towers that connect at their two uppermost stories, which are interconnected via glass bridges with escalators and elevators which crosses the tower's open atrium space in

156-545: A BRCA genetic mutation. A major criterion governing the drugs approval was, on average, its ability to shrink tumours in patients for 7.9 months. In February 2015, the company announced it would acquire the US and Canadian rights to Actavis's branded respiratory drug business for an initial sum of US$ 600 million. Later in the same month the company announced it would partner with Orca Pharmaceuticals to develop retinoic acid -related orphan nuclear receptor gamma inhibitors for use in

234-550: A clinical trial of tremelimumab as a treatment for mesothelioma failed to meet its primary endpoint. As of 2008, David Brennan was paid US$ 1,574,144 for his role as chief executive officer. On 26 April 2012, it was announced that Brennan was to retire in early June of that year. In August 2012, Pascal Soriot was named CEO of AstraZeneca. It was also announced that Leif Johansson would succeed Louis Schweitzer as non-executive chairman on 1 June 2012, three months earlier than previously announced, and would become Chairman of

312-470: A "final offer" from Pfizer of £55 per share, which valued the company at £69.4   billion (US$ 117   billion). The companies had been meeting since January 2014. If the takeover had proceeded, Pfizer would have become the world's biggest drug maker. The transaction would also have been the biggest foreign takeover of a British company. Many in Britain, including politicians and scientists, had opposed

390-474: A Phase I/II trial collaboration with Pharmacyclics and Janssen Biotech investigating combination treatments. Also in November of the same year, the company agreed to sell its lipodystrophy treatment business to Aegerion Pharmaceuticals for more than US$ 325 million. In December, the company received accelerated FDA approval for Olaparib in the treatment of women with advanced ovarian cancer who have

468-542: A catalyst for economic growth, may not serve their intended purpose if they simply shift economic activity, rather than create it. A study done by Jones Lang LaSalle Incorporated (JLL) found that "90 percent of Hudson Yards' new office tenants relocated from Midtown." Some of the more frequent mixed-use scenarios in the United States are: The first large-scale attempt to create mixed-use development in Australia

546-716: A city can be impacted by mixed-use development. With the EPA putting models in the spreadsheet, it makes it much easier for municipalities, and developers to estimate the traffic, with Mixed-use spaces. The linking models also used as a resource tool measures the geography, demographics, and land use characteristics in a city. The Environmental Protection Agency has conducted an analysis on six major metropolitan areas using land usage, household surveys, and GIS databases. States such as California, Washington, New Mexico, and Virginia have adopted this standard as statewide policy when assessing how urban developments can impact traffic. Preconditions for

624-579: A combination of public and private interests, do not show a decrease in carbon emissions in comparison to metropolitan areas that have a low, dense configuration. This is possibly because hybrid metropolises are prone to attract car traffic from visitors. Due to the speculative nature of large scale real estate developments, mega-mixed-use projects often fall short on meeting equity and affordability goals. High-end residential, upscale retail, and Class A office spaces appealing to high-profile tenants are often prioritized due to their speculative potential. There

702-608: A cost of approximately £1 billion. In 2015 AstraZeneca arranged for the establishment of a direct air route between Cambridge and Gothenburg , which began operation on March 2, 2015. The company reserved 20 of the 32 seats on each flight, with the remaining seats available to the public, which was operated SUN-AIR for British Airways . The service connects AstraZeneca’s global headquarters in Cambridge with its research facility in Gothenburg. The service operated four days

780-690: A deal valued at up to $ 1.2 billion. Both the acquisitions were completed in February 2024. In March 2024, AstraZeneca announced it would acquire Amolyt Pharma for $ 1.05 billion in cash. In March 2024, AstraZeneca announced it would acquire Fusion Pharmaceuticals Inc for $ 2 billion in cash. In July 2024, National Institute for Health and Care Excellence (Nice) blocked the National Health Service (NHS) from providing Enhertu , an innovative treatment for advanced HER2-low breast cancer, due to AstraZeneca and Daiichi Sankyo not offering

858-623: A low enough price. Nice's decision, the first rejection of a breast cancer treatment in six years, highlighted the financial challenges of funding complex medicines, with Enhertu costing £117,857 per treatment course. Despite approval by the Medicines and Healthcare Regulatory Agency, Nice's non-recommendation meant the drug could only be available privately or under separate funding in Scotland. Clinical trials showed Enhertu extended patients' lives by five months compared to chemotherapy, but Nice and

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936-808: A major corporate restructuring, including the closure of its research and development activities at Alderley Park in Cheshire and Loughborough in the UK and at Lund in Sweden, investment of $ 500   million in the construction of a new research and development facility in Cambridge and the concentration of R&D in three locations: Cambridge, Gaithersburg, Maryland (location of MedImmune, where it will work on biotech drugs), and Gothenburg in Sweden, for research on traditional chemical drugs. AstraZeneca also announced that it would move its corporate headquarters from London to Cambridge in 2016. That announcement included

1014-635: A majority stake (65%) in Toshiba Building to Nomura Real Estate co. but maintains a 35% ownership. Sekisui House , which serves as the complex's owner and developer, serves as the main tenant of the tower, and serves as the company's headquarters. Mazda has an office in the Umeda Sky Building Tower East. The German consulate-general is located on the thirty-fifth floor of the Umeda Sky Building Tower East. AstraZeneca have their Japanese and Asia-Pacific headquarters in

1092-539: A new Cambridge– Gothenburg service by Sun-Air of Scandinavia . In mid-March the company announced it would co-commercialise naloxegol along with Daiichi Sankyo in a deal worth up to US$ 825 million. Towards the end of April the company announced a number of collaborations worth an estimated US$ 1.8 billion; first, to develop and commercialise MEDI4736, with Celgene , for use against non-Hodgkin’s lymphoma , myelodysplastic syndromes, and multiple myeloma with AstraZeneca receiving US$ 450 million. The second of two deals

1170-467: A new global health tech business, Evinova, that focused on provide global services to CROs and pharma companies to design, run and monitor clinical trials. In December 2023, AstraZeneca announced that it would acquire an RSV vaccine developer, Icosavax for $ 1.1 billion. Later that month, AstraZeneca agreed to acquire clinical-stage biopharmaceutical developer of cell therapies for the treatment of cancer and autoimmune diseases, Gracell Biotechnologies, in

1248-417: A role in 1986 with a zoning bylaw that allowed for commercial and residential units to be mixed. At the time, Toronto was in the beginning stages of planning a focus on developing mixed-use development due to the growing popularity of more social housing. The law has since been updated as recently as 2013, shifting much of its focus outside the downtown area which has been a part of the main city since 1998. With

1326-509: A significant focus on affordable housing provisions in these plans. Mixed-use buildings can be risky given that there are multiple tenants residing in one development. Mega-mixed-use projects, like Hudson Yards , are also extremely expensive. This development has cost the City of New York over 2.2 billion dollars. Critics argue that taxpayer dollars could better serve the general public if spent elsewhere. Additionally, mixed-use developments, as

1404-618: A significant intersection in Toronto, portions of the Mirvish Village project site are zoned as "commercial residential" and others as "mixed commercial residential". Within the City of Toronto's zoning by-laws, commercial residential includes "a range of commercial, residential and institutional uses, as well as parks." Mirvish Village's programmatic uses include rental apartments, a public market, and small-unit retail, while also preserving 23 of 27 heritage houses on site. The project

1482-611: A single building, a block or neighborhood, or in zoning policy across an entire city or other administrative unit. These projects may be completed by a private developer, (quasi-)governmental agency, or a combination thereof. A mixed-use development may be a new construction, reuse of an existing building or brownfield site , or a combination. Traditionally, human settlements have developed in mixed-use patterns. However, with industrialization , governmental zoning regulations were introduced to separate different functions, such as manufacturing, from residential areas. Public health concerns and

1560-665: A spin-off of the Sanofi-Aventis anti-infectives division. Astra acquired the experimental antibiotic NXL-104 (CEF104) (CAZ-AVI) through this acquisition. In 2011, AstraZeneca acquired Guangdong BeiKang Pharmaceutical Company, a Chinese generics business. In February 2012, AstraZeneca and Amgen announced a collaboration on treatments for inflammatory diseases. Then in April 2012, AstraZeneca acquired Ardea Biosciences, another biotechnology company, for $ 1.26 billion. In June 2012, AstraZeneca and Bristol Myers Squibb announced

1638-569: A strong ability to adapt to changing social and economic environments. When the COVID-19 pandemic hit, New York retailers located on long, commercially oriented blocks suffered severely as they were no longer attracting an audience of passersby. By combining multiple functions into one building or development, mixed-use districts can build resiliency through their ability to attract and maintain visitors. More sustainable transportation practices are also fostered. A study of Guangzhou, China , done by

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1716-493: A three-year collaboration with Mitsubishi Tanabe Pharma on diabetic nephropathy . In September 2014 the company would join forces with Eli Lilly in developing and commercialising its candidate BACE inhibitor – AZD3292 – used for the treatment of Alzheimer's disease . The deal could yield up to US$ 500 million for the company. In November 2014 the company's biologics R&D operation, MedImmune, agreed to acquire Definiens for more than US$ 150 million. The company also began

1794-543: A two-stage deal for the joint acquisition of the biotechnology company Amylin Pharmaceuticals . It was agreed that Bristol Myers Squibb would acquire Amylin for $ 5.3 billion in cash and the assumption of $ 1.7 billion in debt, with AstraZeneca then paying $ 3.4 billion in cash to Bristol Myers Squibb, and Amylin being folded into an existing diabetes joint venture between AstraZeneca and Bristol Myers Squibb. In March 2013 AstraZeneca announced plans for

1872-460: A week and was intended to support collaboration between staff in the two locations, allowing same-day travel for meetings. The route ended as a scheduled public service in 2016 due to insufficient demand, but these flights continue for AstraZeneca employees as of 2024. In April 2015, AstraZeneca's drug tremelimumab was approved as an orphan drug for the treatment of mesothelioma in the United States. In February 2016, AstraZeneca announced that

1950-543: Is a British-Swedish multinational pharmaceutical and biotechnology company with its headquarters at the Cambridge Biomedical Campus in Cambridge , England. It has a portfolio of products for major diseases in areas including oncology , cardiovascular , gastrointestinal , infection , neuroscience , respiratory , and inflammation . The company was founded in 1999 through the merger of

2028-618: Is also a trend towards making residential spaces in mixed-use developments to be condominiums, rather than rental spaces. A study done by the Journal of the American Planning Association found that a focus on homeownership predominantly excludes individuals working in public services, trades, cultural, sales and service, and manufacturing occupations from living in amenity-rich city centers. Despite incentives like density bonuses, municipalities and developers rarely put

2106-462: Is also absent in Germany and Russia where zoning codes make no distinction between different types of housing. America's attachment to private property and the traditional 1950s suburban home, as well as deep racial and class divides, have marked the divergence in mixed-use zoning between the continents. As a result, much of Europe's central cities are mixed use "by default" and the term "mixed-use"

2184-535: Is also found in these districts. This development pattern is centered around the idea of "live, work, play," transforming buildings and neighborhoods into multi-use entities. Efficiency, productivity, and quality of life are also increased with regards to workplaces holding a plethora of amenities. Examples include gyms, restaurants, bars, and shopping. Mixed-use neighborhoods promote community and socialization through their bringing together of employees, visitors, and residents. A distinctive character and sense-of-place

2262-446: Is an agreement to study a combination treatment of MEDI4736 and Innate Pharma's Phase II anti-NKG2A antibody IPH2201 for up to US$ 1.275 billion. The company's MedImmune arm also launched collaborative clinical trials with Juno Therapeutics , investigating combination treatments for cancer. The trials will assess combinations of MEDI4736 and one of Juno Therapeutics' CD19 directed chimeric antigen receptor T-cell candidates. In late June

2340-399: Is created by transforming single use districts that may run for eight hours a day (ex. commercial office buildings running 9am - 5pm) into communities that can run eighteen hours a day through the addition of cafes, restaurants, bars, and nightclubs. Safety of neighborhoods in turn may be increased as people stay out on the streets for longer hours. Mixed-use neighborhoods and buildings have

2418-422: Is incentivized in these regions. By taking undervalued and underutilized land, often former heavy industrial, developers can repurpose it to increase land and property values.  These projects also increase housing variety, density, and oftentimes affordability through their focus on multifamily, rather than single-family housing compounds. A more equal balance between the supply and demand of jobs and housing

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2496-717: Is much more relevant regarding new areas of the city where an effort is made to mix residential and commercial activities – such as in Amsterdam's Eastern Docklands . Expanded use of mixed-use zoning and mixed-use developments may be found in a variety of contexts, such as the following (multiple such contexts might apply to one particular project or situation): Any of the above contexts may also include parallel contexts such as: Mixed-use developments are home to significant employment and housing opportunities. Many of these projects are already located in established downtown districts, meaning that development of public transit systems

2574-582: Is notable for its public consultation process, which was lauded by Toronto city officials. Architect Henriquez and the developer had previously collaborated on mixed-use projects in Vancouver , British Columbia , including the successful Woodward's Redevelopment . In the United States, the Environmental Protection Agency (EPA) collaborates with local governments by providing researchers developing new data that estimates how

2652-725: Is on the London Stock Exchange and is a constituent of the FTSE 100 Index ; it also has a secondary listing on the Nasdaq Stockholm . It is also listed on the American Nasdaq and is a Nasdaq-100 company. AstraZeneca has one of the highest market capitalisations of pharmaceutical companies worldwide. Astra AB was founded in 1913 in Södertälje , Sweden , by 400 doctors and apothecaries . In 1993

2730-573: Is the US's largest project to ever be financed by TIF ( tax increment financing ) subsidies. It did not require voter approval, nor did it have to go through the city's traditional budgeting process. Rather, the project is financed by future property taxes and the EB-5 Visa Program. This program provides VISAs to overseas investors in exchange for placing a minimum of $ 500,000 into US real estate. AstraZeneca AstraZeneca plc ( / ˌ æ s t r ə ˈ z ɛ n ə k ə / ) ( AZ )

2808-491: The Cambridge Biomedical Campus adjacent to Addenbrooke's Hospital in Cambridge , United Kingdom . This facility, known as the Discovery Centre , was designed by Swiss architecture firm Herzog & de Meuron and officially opened by Prince Charles on the 23 November 2021. The building is designed to accommodate over 2,200 scientists across 16 laboratories covering approximately 19,000 square meters. built at

2886-472: The 1960s. Since the 1990s, mixed-use zoning has once again become desirable as it works to combat urban sprawl and increase economic vitality. In most of Europe, government policy has encouraged the continuation of the city center's role as a main location for business, retail, restaurant, and entertainment activity, unlike in the United States where zoning actively discouraged such mixed use for many decades. In England, for example, hotels are included under

2964-529: The American pharmaceutical business, Moderna . In March 2019, AstraZeneca announced it will pay up to US$ 6.9 billion to work with Daiichi Sankyo Co Ltd on an experimental treatment for breast cancer. AstraZeneca plans to use some of the proceeds of a US$ 3.5 billion share issue to fund the deal. The deal on the drug known as trastuzumab deruxtecan sent shares in Japan's Daiichi soaring 16%. In September 2019,

3042-666: The British chemicals company ICI (established from four British chemical companies) demerged its pharmaceuticals businesses and its agrochemicals and specialities businesses, to form Zeneca Group PLC . Finally, in 1999 Astra and Zeneca Group merged to form AstraZeneca plc, with its headquarters in London. In 1999, AstraZeneca identified a new location for the company's US base, the "Fairfax-plus" site in North Wilmington , Delaware. In 2002, its drug Iressa (gefitinib)

3120-556: The East Tower. PlatinumGames is also located in the building. Mixed-use development Mixed use is a type of urban development , urban design , urban planning and/or a zoning classification that blends multiple uses , such as residential, commercial, cultural, institutional, or entertainment, into one space, where those functions are to some degree physically and functionally integrated, and that provides pedestrian connections. Mixed-use development may be applied to

3198-790: The Journal of Geographical Information Science, found that taxis located in regions where buildings housed a greater variety of functions had greatly reduced traveling distances. Shorter traveling distances, in turn, support the use of micro-mobility . Pedestrian and bike-friendly infrastructure are fostered due to increased density and reduced distances between housing, workplaces, retail businesses, and other amenities and destinations. Additionally, mixed-use projects promote health and wellness, as these developments often provide better access (whether it be by foot, bicycle, or transit) to farmer's markets and grocery stores. However, hybrid metropolises, areas that have large and tall buildings which accommodate

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3276-466: The Pennsylvania Bio commerce organisation. In 2006, following a collaborative relationship begun in 2004, AstraZeneca acquired Cambridge Antibody Technology for £702 million. In February 2007, AstraZeneca agreed to buy Arrow Therapeutics, a company focused on the discovery and development of anti-viral therapies, for US$ 150   million. AstraZeneca's pipeline, and "patent cliff", was

3354-666: The Shin Umeda City General Information Center. It is also located near key transport hubs such as the Ōsaka Station and the Umeda Station , both of which serves as one of the most busiest railway stations in both Japan and the world. The building primarily highlights a rooftop observatory, named the Kuchu Teien Observatory , which is also known as The Floating Garden Observatory . The two-floor observatory serves as

3432-853: The Swedish Astra AB and the British Zeneca Group (itself formed by the demerger of the pharmaceutical operations of Imperial Chemical Industries in 1993). Since the merger it has been among the world's largest pharmaceutical companies and has made numerous corporate acquisitions, including Cambridge Antibody Technology (in 2006), MedImmune (in 2007), Spirogen (in 2013) and Definiens (by MedImmune in 2014). It has its research and development concentrated in three strategic centres: Cambridge, England; Gothenburg , Sweden and Gaithersburg in Maryland , U.S. AstraZeneca traces its earliest corporate history to 1913, when Astra AB

3510-468: The Umeda district and the entire Osaka Skyline in three dimensions. The towers' construction process started with the construction of the twin towers using reinforced concrete, while the construction of the sky deck began afterwards. As the structural works of the towers were completed, the sky deck was raised to the ground using the lift-up construction method, which used a set of hydraulic elevators to raise

3588-615: The United Kingdom approved the emergency use of the Oxford–AstraZeneca COVID-19 vaccine . In July 2021, AstraZeneca acquired Alexion Pharmaceuticals . In October 2021, the company, through Alexion, acquired Caelum Biosciences and its monoclonal treatment (CAEL-101) for light chain (AL) amyloidosis for up to $ 500 million. In July, the company announced it would acquire TeneoTwo for up to $ 1.3 billion, increasing its blood cancer drug offering. In October 2022 it

3666-409: The United Kingdom. However, it had slowed decision making for new investment projects waiting for a post-Brexit regulatory regime to settle down. In September 2017, the company's chairman Leif Johansson planned in taking the "first steps" in moving its research and manufacturing operations away from the United Kingdom, if there is a hard Brexit. In 2017, it was the eleventh largest drug company in

3744-457: The United States came after World War II when planner and New York City Parks Commissioner , Robert Moses , championed superhighways to break up functions and neighborhoods of the city. The antithesis to these practices came from activist and writer, Jane Jacobs , who was a major proponent of mixed-use zoning, believing it played a key role in creating an organic, diverse, and vibrant streetscape. These two figures went head-to-head during much of

3822-582: The Vegetable Garden, while the fourth tower was planned located along the eastern side of the third tower. Eventually, the Japan economic bubble of the 1980s caused widespread damage to the Japanese economy and brought the total number of towers down to two towers. During the architectural planning of the complex, Hiroshi Hara created the overall concept of the towers are based on two key concepts:

3900-439: The announcement that it would cut 1,600 jobs; three days later it announced it would cut an additional 2,300 jobs. It also announced that it would focus on three therapeutic areas: Respiratory Inflammation & Autoimmunity, Cardiovascular & Metabolic Disease, and Oncology. In October 2013, AstraZeneca announced it would acquire biotech oncology company Spirogen for around US$ 440 million. On 19 May 2014 AstraZeneca rejected

3978-681: The companies could not agree on a new price. The following is an illustration of the company's major mergers and acquisitions and historical predecessors: AstraZeneca develops, manufactures and sells pharmaceutical and biotechnology products to treat disorders in the oncology , cardiovascular , gastrointestinal , infection , neuroscience , respiratory and inflammation areas. AstraZeneca has its corporate headquarters in Cambridge, United Kingdom, and its main research and development (R&D) centres are in Cambridge (UK), Gaithersburg (Maryland, US), Gothenburg (Sweden) and Warsaw (Poland). AstraZeneca's global headquarters are located in

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4056-622: The company announced it had acquired the global rights to develop and commercialise Heptares Therapeutics' drug candidate HTL-1071, which focuses on blocking the adenosine A2A receptor, in a deal worth up to US$ 510 million. In the same month the company's MedImmune subsidiary acquired exclusive rights to Inovio Pharmaceuticals' INO-3112 immunotherapy, currently in Phase I/II, under an agreement which could net more than US$ 727.5 million for Inovio. INO-3112 targets Human papillomavirus types 16 and 18. In September, Valeant licensed Brodalumab from

4134-559: The company announced it has entered into a partnership agreement with Eolas Therapeutics on the Eolas Orexin-1 Receptor Antagonist (EORA) program for smoking cessation and other treatments. In July the company announced it would sell off its rights to Entocort ( budesonide ) to Tillotts Pharma for US$ 215 million. In July 2015, Genzyme announced it would acquire the rare cancer drug Caprelsa ( vandetanib ) from AstraZeneca for up to US$ 300 million. In August,

4212-526: The company announced that it would cease drug production at its German headquarters in Wedel , leading to the loss of 175 jobs by the end of 2021. In October 2019, AstraZeneca announced it would sell the global commercial rights for its drug to treat acid reflux to German pharmaceutical company Cheplapharm Arzneimittel GmbH for as much as US$ 276 million. In February 2020, AstraZeneca agreed to sublicense its global rights (except Europe, Canada and Israel) to

4290-458: The company for up to US$ 445 million. On 6 November it was reported that AstraZeneca had acquired ZS Pharma for US$ 2.7 billion. In December the company announced its intention to acquire the respiratory portfolio of Takeda Pharmaceutical – namely Alvesco and Omnaris – for US$ 575 million A day later, the company announced it had taken a 55% majority stake in Acerta for US$ 4 billion. As part of

4368-470: The deal. In July 2014 the company entered into a deal with Almirall to acquire its subsidiary Almirall Sofotec and its lung treatments including the COPD drug, Eklira. The US$ 2.1 billion deal included an allocation of US$ 1.2 billion for development in the respiratory franchise, one of AstraZeneca's three target therapeutic areas announced the year before. In August 2014 the company announced it had entered into

4446-517: The development of DS-1062, an antibody drug conjugate. The deal could potentially be worth up to US$ 6 billion for Daiichi. In September 2020, AstraZeneca acquired the preclinical oral PCSK9 inhibitor program from Dogma Therapeutics. On 27 December 2020, AstraZeneca CEO Pascal Soriot said that they have “figured out the winning formula” with their two-dose system with the Oxford University ’s COVID-19 vaccine . On 30 December 2020,

4524-437: The drug Movantik , to Redhill Biopharma. In June 2020, AstraZeneca made a preliminary approach to Gilead Sciences about a potential merger, worth almost US$ 240 billion. However, these plans were subsequently dropped because it would have distracted the company from its own pipeline and ongoing COVID-19 vaccine efforts. In July 2020, the business entered into its second collaboration with Daiichi Sankyo , centred around

4602-531: The early 1990s, when the local government wanted to reduce the then-dominant car-oriented development style. The Metropolitan Area Express , Portland's light rail system, encourages the mixing of residential, commercial, and work spaces into one zone. With this one-zoning-type planning system, the use of land at increased densities provides a return in public investments throughout the city. Main street corridors provide flexible building heights and high density uses to enable "gathering places". Hudson Yards project

4680-595: The first concept was to create a modern landmark in the city featuring modern architecture , and drew inspiration from the Grande Arche in Paris , France , which features a hypercube -like design. The second concept within the complex is to emphasize a vision of a "floating city", which can be reflected from the city's urban landscape and is contrasted with the opaque ceramic atrium at the ground floor. The concept also included open-air like amenities and viewing decks of

4758-404: The ground floor area. It is currently the fifteenth-tallest building in the prefecture, and is one of the city's most recognizable landmarks. The towers reached a total height of 170 m (557.74 ft) while the overall height of the tower including the towers' spires is at 190 metres (623.4 ft). The towers were designed by Hiroshi Hara , and was constructed by Takenaka Corporation and

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4836-456: The initial one with new policies focused on economic and urban renewal issues. In particular, the 1988 Plan was designed in collaboration with a transport strategy and was the first to recommend higher development densities. Since then, Australian planning authorities have given greater priority to mixed-use development of inner-city industrial land as a way of revitalising areas neglected by the decline in manufacturing, consolidating and densifying

4914-412: The previously underpopulated urban centres. This new urban planning approach has had a significant impact on the use of land parcels in major Australian cities: according to 2021 data from Australian Bureau of Statistics , mixed zoning already suppose more than 9% of new housing approvals. One of the first cities to adopt a policy on mixed-use development is Toronto . The local government first played

4992-441: The protection of property values stood as the motivation behind this separation. In the United States, the practice of zoning for single-family residential use was instigated to safeguard communities from negative externalities , including air, noise, and light pollution, associated with heavier industrial practices. These zones were also constructed to alleviate racial and class tensions. The heyday of separate-use zoning in

5070-501: The regulations in place, the city has overseen the development of high-rise condominiums throughout the city with amenities and transit stops nearby. Toronto's policies of mixed-use development have inspired other North American cities in Canada and the United States to bring about similar changes. One example of a Toronto mixed-use development is Mirvish Village by architect Gregory Henriquez . Located at Bloor and Bathurst Street ,

5148-405: The same umbrella as "residential," rather than commercial as they are classified under in the US. France similarly gravitates towards mixed-use as much of Paris is simply zoned to be "General Urban," allowing for a variety of uses. Even zones that house the mansions and villas of the aristocrats focus on historical and architectural preservation rather than single family zoning. Single family zoning

5226-534: The section upwards, and is the first time to be introduced within a construction project. The installation of the glass-layered escalators and elevators also followed the same system. The tower was fully completed and began opening its doors to the public on March 25, 1993. The two-tower skyscrapers sits within the Shin-Umeda City, a 4.34-hectare (10.7-acre) mixed-use area which includes The Westin Osaka , and

5304-494: The subject of much speculation in April 2007 leading to pipeline-boosting collaboration and acquisition activities. A few days later AstraZeneca acquired US company MedImmune for about US$ 15.2 billion to gain flu vaccines and an anti-viral treatment for infants; AstraZeneca subsequently consolidated all of its biologics operations into a dedicated biologics division called MedImmune. In 2010, AstraZeneca acquired Novexel Corp, an antibiotics discovery company formed in 2004 as

5382-463: The success of mixed-use developments are employment, population, and consumer spending . The three preconditions ensure that a development can attract quality tenants and financial success. Other factors determining the success of the mixed-use development is the proximity of production time, and the costs from the surrounding market. Mixed-use zoning has been implemented in Portland, Oregon , since

5460-587: The towers' main attraction and also features Café Sky 40 and the Fence of Vows. The tower also has an underground market that attempts to recreate the atmosphere of Osaka in the early 20th century. The base of the towers also presents two sets of urban gardens with walking trails and water features, namely the Island Garden, and the Vegetable Garden. The building was mainly owned by Toshiba Corporation through Toshiba Building Co., Ltd. In July 2008, Toshiba sold

5538-595: The transaction the company will gain commercial rights to Acerta's irreversible oral Bruton's tyrosine kinase inhibitor, acalabrutinib (ACP-196), which is currently in Phase III development for B-cell blood cancers and in Phase I or II clinical trials in solid tumours. In 2015, it was the eighth-largest drug company in the world based on sales revenue. In July 2017, the company's CEO Pascal Soriot said that Brexit would not affect its commitment to its current plans in

5616-476: The treatment of a number of autoimmune diseases, which could generate up to US$ 122.5 million for Orca. The company also announced its plan to spend US$ 40 million creating a new subsidiary focused on small molecule anti-infectives – primarily in the research of the gyrase inhibitor, AZD0914 , which is currently in Phase II for the treatment of gonorrhea . The company underwrote twenty out of thirty-two seats of

5694-459: The world based on sales and ranked seventh based on R&D investment. In January EVP Pam Cheng stated that AstraZeneca has ignited startup of duplicate QA testing facility in Sweden and has initiated hiring in Sweden. In February 2018, AstraZeneca announced it was spinning off six early-stage experimental drugs into a new biotechnology company, known as Viela Bio, valued at US$ 250 million. On 6 December 2018, AstraZeneca purchased nearly 8% of

5772-460: Was announced that the company would acquire LogicBio Therapeutics, which was active in clinical-stage genomic medicine . In November 2022, it was announced AstraZeneca had acquired the Amsterdam -headquartered clinical-stage biotechnology company, Neogene Therapeutics. In January, AstraZeneca announced it would acquire CinCor Pharma for $ 1.8 billion. In November 2023, AstraZeneca launched

5850-408: Was approved in Japan as monotherapy for non-small cell lung cancer . On 3 January 2004 Dr Robert Nolan, a former director of AstraZeneca, formed the management team of ZI Medical. In 2005, the company acquired KuDOS Pharmaceuticals, a UK biotech company, for £120 million. and entered into an anti-cancer collaboration agreement with Astex It also announced that it had become a Diamond Member of

5928-515: Was completed in 1993. The building was originally conceived in 1988 as the "City of Air" project, a planned mixed-use skyscraper which was envisioned to create four interconnected towers in northern Osaka, located within the Umeda central business district and is at close proximity to the Yodo River . The third tower of the complex was initially planned to be constructed within the current site of

6006-460: Was formed by a large group of doctors and apothecaries in Södertälje. Throughout the twentieth century, it grew into the largest pharmaceutical company in Sweden. Its British counterpart, Zeneca PLC was formed in 1993 when ICI divested its pharmaceuticals businesses; Astra AB and Zeneca PLC merged six years later, with the chosen headquarters in the United Kingdom. AstraZeneca's primary listing

6084-670: Was the Sydney Region Outline Plan , a plan that identified Sydney 's need to decentralise and organise its growth around the metropolitan area. Its main objective was to control the city's rapid post-war population growth by introducing growth corridors and economic centres that would help prevent uncontrolled sprawl and the overuse of the car as a means of transport Several city centres such as Parramatta or Campbelltown benefited from these policies, creating economic hubs with his own inner-city amenities along Sydney's main thoroughfares. Subsequent plans complemented

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