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93-567: MCI Concord was a level 4, medium level security prison. The prison is located in Concord, Massachusetts on state Route 2 . A Massachusetts State Police barracks (Troop A-3) and the Northeastern Correctional Center (Minimum Security) are located across the highway from the prison. The prison was designed to house 550-600 medium security inmates, but as of 2024 the population had declined to about 300. MCI-Concord

186-494: A strain of coronavirus known as "severe acute respiratory syndrome coronavirus 2" ( SARS-CoV-2 ). COVID-19 is mainly transmitted when people breathe in air contaminated by droplets / aerosols and small airborne particles containing the virus. Infected people exhale those particles as they breathe, talk, cough, sneeze, or sing. Transmission is more likely the closer people are. However, infection can occur over longer distances, particularly indoors. The transmission of

279-419: A certain critical size, generally thought to be <100μm diameter, evaporate faster than they settle; due to that fact, they form respiratory aerosol particles that remain airborne for a long period of time over extensive distances. Infectivity can begin four to five days before the onset of symptoms. Infected people can spread the disease even if they are pre-symptomatic or asymptomatic . Most commonly,

372-523: A compromise, proclaiming the day as Patriots' Day . In April 1975, Concord hosted a bicentennial celebration of the battle, featuring an address at the Old North Bridge by President Gerald Ford . Concord has a remarkably rich literary history centered in the 19th century around Ralph Waldo Emerson (1803–1882), who moved there in 1835 and quickly became its most prominent citizen. A successful lecturer and philosopher, Emerson had deep roots in

465-422: A higher risk of developing severe symptoms. Some complications result in death. Some people continue to experience a range of effects ( long COVID ) for months or years after infection, and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease. COVID‑19 transmission occurs when infectious particles are breathed in or come into contact with

558-470: A manner indistinguishable from the American pronunciation of the word "conquered." In the local dialect of Greater Boston , it is frequently heard with the [ər] in the second syllable replaced by [ ʏ ] ( [ˈkɒŋkʏd] KAHN -kəd ). According to Concord's 2016 Comprehensive Annual Financial Report, the principal employers in the town are: Concord and West Concord stations are served by

651-423: A range of effects, such as fatigue , for prolonged periods after an initial COVID-19 infection. This is the result of a condition called long COVID , which can be described as a range of persistent symptoms that continue for months or years. Long-term damage to organs has been observed after the onset of COVID-19. Multi-year studies are underway to further investigate the protracted effects of long COVID. Reducing

744-580: A small cabin near Walden Pond , where he wrote Walden (1854). After being imprisoned in the Concord jail for refusing to pay taxes in political protest against slavery and the Mexican–American War , Thoreau penned the influential essay "Resistance to Civil Government", popularly known as Civil Disobedience (1849). Evidencing their strong political beliefs through actions, Thoreau and many of his neighbors served as station masters and agents on

837-625: A special riot squad of the Massachusetts State Police put down a mass attempt at escape from the Concord State Reformatory. State Police quelled escape attempt by 59 convicts at Concord Reformatory; rescue 13 guards, 2 civilians held as hostages. On November 22, 1972, inmates in E Building began rioting and causing a major disturbance. Correction officers requested assistance and seventy-five state police officers (along with four sharpshooters) were sent to

930-551: A vote of 265 to 272. The ban on selling water in polyethylene terephthalate (PET) bottles of one liter or less passed in 2012 by a vote of 403 to 364, and a repeal effort in April failed by a vote of 621 to 687. According to the United States Census Bureau , the town has a total area of 25.9 square miles (67 km ), of which 24.9 square miles (64 km ) is land and 1.0 square mile (2.6 km ), or 3.75%,

1023-744: Is a novel severe acute respiratory syndrome coronavirus. It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan. All structural features of the novel SARS-CoV-2 virus particle occur in related coronaviruses in nature, particularly in Rhinolophus sinicus (Chinese horseshoe bats). Outside the human body, the virus is destroyed by household soap which bursts its protective bubble . Hospital disinfectants, alcohols, heat, povidone-iodine , and ultraviolet -C (UV-C) irradiation are also effective disinfection methods for surfaces. SARS-CoV-2

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1116-571: Is associated with COVID-19 and is reported in as many as 88% of symptomatic cases. Published data on the neuropathological changes related with COVID-19 have been limited and contentious, with neuropathological descriptions ranging from moderate to severe hemorrhagic and hypoxia phenotypes , thrombotic consequences, changes in acute disseminated encephalomyelitis (ADEM-type), encephalitis and meningitis . Many COVID-19 patients with co-morbidities have hypoxia and have been in intensive care for varying lengths of time, confounding interpretation of

1209-433: Is available, guidelines and recommendations for hypertensive patients remain. The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to

1302-402: Is because pregnant women with COVID‑19 appear to be more likely to develop respiratory and obstetric complications that can lead to miscarriage , premature delivery and intrauterine growth restriction . Fungal infections such as aspergillosis , candidiasis , cryptococcosis and mucormycosis have been recorded in patients recovering from COVID‑19. COVID‑19 is caused by infection with

1395-522: Is closely related to the original SARS-CoV . It is thought to have an animal ( zoonotic ) origin. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus , in subgenus Sarbecovirus (lineage B) together with two bat-derived strains. It is 96% identical at the whole genome level to other bat coronavirus samples (BatCov RaTG13 ). The structural proteins of SARS-CoV-2 include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and

1488-595: Is the cause of the bud release and the formation of the viral envelope. The N and E protein are accessory proteins that interfere with the host's immune response. Human angiotensin converting enzyme 2 (hACE2) is the host factor that SARS-CoV-2 virus targets causing COVID‑19. Theoretically, the usage of angiotensin receptor blockers (ARB) and ACE inhibitors upregulating ACE2 expression might increase morbidity with COVID‑19, though animal data suggest some potential protective effect of ARB; however no clinical studies have proven susceptibility or outcomes. Until further data

1581-469: Is the viral component that attaches to the host receptor via the ACE2 receptors. It includes two subunits: S1 and S2. Studies have shown that S1 domain induced IgG and IgA antibody levels at a much higher capacity. It is the focus spike proteins expression that are involved in many effective COVID‑19 vaccines. The M protein is the viral protein responsible for the transmembrane transport of nutrients. It

1674-529: Is water. The city of Lowell is 13 miles (21 km) to the north, Boston is 19 miles (31 km) to the east, and Nashua, New Hampshire , is 23 miles (37 km) to the north. Massachusetts state routes 2 , 2A , 62 , 126 , 119 , 111 , and 117 pass through Concord. The town center is near the confluence of the Sudbury and Assabet rivers, forming the Concord River , which flows north to

1767-605: The Los Angeles Times characterized the ban as "born of convoluted reasoning" and "wrongheaded." Some residents believed the ban would do little to affect the sales of bottled water, which was still highly accessible in the surrounding areas, and that it restricted consumers' freedom of choice. Opponents also considered the ban to unfairly target one product in particular, when other, less healthy alternatives such as soda and fruit juice were still readily available in bottled form. Nonetheless, subsequent efforts to repeal

1860-424: The 2020 census , the town population was 18,491. The United States Census Bureau considers Concord part of Greater Boston . The town center is near where the Sudbury and Assabet rivers join to form the Concord River . The area that became the town of Concord was originally known as Musketaquid , an Algonquian word for "grassy plain." Concord was established in 1635 by a group of English settlers; by 1775,

1953-938: The Alpha variant (B.1.1.7, formerly called the UK variant), first found in London and Kent, the Beta variant (B.1.351, formerly called the South Africa variant), the Gamma variant (P.1, formerly called the Brazil variant), the Delta variant (B.1.617.2, formerly called the India variant), and the Omicron variant (B.1.1.529), which had spread to 57 countries as of 7 December. On December 19, 2023,

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2046-755: The COVID-19 pandemic . The symptoms of COVID‑19 are variable but often include fever, fatigue, cough, breathing difficulties , loss of smell , and loss of taste . Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms . Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging), and 5% develop critical symptoms ( respiratory failure , shock , or multiorgan dysfunction ). Older people are at

2139-693: The Charlestown State Prison in Charlestown, Massachusetts and Concord became the "Massachusetts Reformatory" where prisoners under 30 years of age received a one number maximum term for the crime they were convicted of and the Massachusetts Parole Board could release the offender a month after their judgment, or anytime up to their maximum term. If the offender proved to be reformed of the behavior that caused his incarceration he would be put on supervised parole which

2232-455: The MBTA 's Fitchburg Line . Yankee Line provides commuter bus service between Concord and Boston. Concord's sister cities are: Concord is featured in the 2012 video game Assassin's Creed 3 , the 2020 video game Assassin's Creed Valhalla and the 2015 video game Fallout 4 . The video game Walden, a game , based on Henry David Thoreau's Walden, is set in the town. Scenes from

2325-693: The Merrimack River in Lowell. Gunpowder was manufactured from 1835 to 1940 in the American Powder Mills complex extending upstream along the Assabet River. Local government consists of a five-member executive Select Board and a legislature utilizing open town meeting . On the federal level, Concord is part of Massachusetts's 3rd congressional district , represented by Lori Trahan . The state's senior ( Class I ) member of

2418-618: The Old North Bridge , leading to a number of casualties on both sides and forcing them to fall back and rejoin the Army's main force. After the British completed their search for the cache in Concord, they marched back to Boston, but were constantly attacked by minutemen in hit-and-run attacks, suffering more casualties before reaching Charlestown, Boston . The minutemen then blockaded the narrow land accesses to Charlestown, initiating

2511-588: The Spanish flu , Middle East respiratory syndrome , and Zika virus . In January 2020, the World Health Organization (WHO) recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 guidance and international guidelines against using geographical locations or groups of people in disease and virus names to prevent social stigma . The official names COVID‑19 and SARS-CoV-2 were issued by

2604-654: The Underground Railroad . The Wayside , a house on Lexington Road, has been home to several authors. It was occupied by scientist John Winthrop (1714–1779) when Harvard College was temporarily moved to Concord during the Revolutionary War. The Wayside was later the home of the Alcott family (who referred to it as "Hillside"); the Alcotts sold it to Hawthorne in 1852, and the family moved into

2697-739: The United States Senate is Elizabeth Warren . The junior ( Class II ) senator is Ed Markey . At the 2020 census, there were 18,491 people, 7,295 housing units and 6,439 families residing in the town. The population density was 714.0 inhabitants per square mile (275.7/km ). The average density of housing units was 282.0 per square mile (108.9/km ). The racial makeup of the town was 82.94% White , 2.61% African American , 6.18% Asian , 4.55% Hispanic or Latino (of any race), 0.02% Native American , 0.02% Pacific Islander , 1.02% from other races , and 6.86% from two or more races. There were 6,439 families, of which 35.98% had children under

2790-583: The siege of Boston . Poet Ralph Waldo Emerson subsequently described the shot fired by the minutemen at the Old North Bridge in his 1837 poem " Concord Hymn " as the " shot heard round the world ". In 1894, the Lexington Historical Society petitioned the Massachusetts State Legislature to proclaim April 19 "Lexington Day"; Concord countered with "Concord Day". Governor Frederic T. Greenhalge opted for

2883-482: The small intestine . The virus can cause acute myocardial injury and chronic damage to the cardiovascular system . An acute cardiac injury was found in 12% of infected people admitted to the hospital in Wuhan, China, and is more frequent in severe disease. Rates of cardiovascular symptoms are high, owing to the systemic inflammatory response and immune system disorders during disease progression, but acute myocardial injuries may also be related to ACE2 receptors in

Massachusetts Correctional Institution – Concord - Misplaced Pages Continue

2976-710: The spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat SARS-CoV, maintains around 98% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only around 38% with the M protein of MERS-CoV . The many thousands of SARS-CoV-2 variants are grouped into either clades or lineages . The WHO, in collaboration with partners, expert networks, national authorities, institutions and researchers, have established nomenclature systems for naming and tracking SARS-CoV-2 genetic lineages by GISAID , Nextstrain and Pango . The expert group convened by

3069-579: The 2017 comedy film Daddy's Home 2 were filmed at Concord scout house. Parts of the 2019 film Little Women were shot on the Concord River . Jane Langton 's Homer Kelly murder mystery novels are largely set in Concord. Her 1964 novel 'The Transcendental Murder' was described in the Boston Globe in 1975 as 'a hymn to Concord, its history, its houses, its hallowed ground, its people and patriots, and its ghosts (Emerson and Thoreau)'. Italian director Lucio Fulci 's 1981 horror film The House by

3162-405: The 20th century, Concord developed into an affluent Boston suburb and tourist destination, drawing visitors to the Old North Bridge , Orchard House and Walden Pond . The town retains its literary culture and is home to notable authors, including Doris Kearns Goodwin , Alan Lightman and Gregory Maguire . Concord is also notable for its progressive and environmentalist politics, becoming in 2012

3255-521: The Acts of 1955, c. 770, all the prisons were merely renamed, "MCI-(at the city or town the prison was located). In 1955, the state prison at Walpole , and the reformatory at Concord were in fact "two" distinct "maximum" security facilities. In 1972, c. 777, s.8, the Massachusetts reformatory "name" was changed to be, "MCI-Concord." Only the name was changed. Court commitments from District Courts to

3348-517: The Alcotts are buried on Authors' Ridge in Concord's Sleepy Hollow Cemetery . The 20th-century composer Charles Ives wrote his Concord Sonata ( c.  1904–1915 ) as a series of impressionistic portraits of literary figures associated with the town. Concord maintains a lively literary culture to this day; notable authors who have called the town home in recent years include Doris Kearns Goodwin , Alan Lightman , Robert B. Parker , and Gregory Maguire . In 1849, Ephraim Wales Bull developed

3441-560: The Army's march by Samuel Prescott on April 18, quickly mustered and confronted the British in Lexington . Though who fired the first shot is unknown, a firefight broke out and the British fired a volley at the Americans before dispersing them with a bayonet charge , killing eight. The British proceeded into Concord and dispersed into company-sized formations to search for the cache. At 11:00am, 400 minutemen engaged 100 British troops at

3534-548: The B.1 lineage. Several notable variants of SARS-CoV-2 emerged throughout 2020. Cluster 5 emerged among minks and mink farmers in Denmark . After strict quarantines and the slaughter of all the country's mink , the cluster was assessed to no longer be circulating among humans in Denmark as of 1 February 2021. As of December 2021 , there are five dominant variants of SARS-CoV-2 spreading among global populations:

3627-542: The CNS, possibly within an infected white blood cell. Research conducted when Alpha was the dominant variant has suggested COVID-19 may cause brain damage. Later research showed that all variants studied (including Omicron) killed brain cells, but the exact cells killed varied by variant. It is unknown if such damage is temporary or permanent. Observed individuals infected with COVID-19 (most with mild cases) experienced an additional 0.2% to 2% of brain tissue lost in regions of

3720-562: The COVID-19 infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: a respiratory symptom cluster with cough, sputum , shortness of breath , and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; and a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhea. In people without prior ear, nose, or throat disorders, loss of taste combined with loss of smell

3813-765: The Cemetery was partly filmed in Concord - notably the Holy Family Church, a Main Street realty and the Concord Free Public Library . The Mother-Daughter Book Club series of children's novels is set in Concord. COVID-19 Coronavirus disease 2019 ( COVID-19 ) is a contagious disease caused by the coronavirus SARS-CoV-2 . The first known case was identified in Wuhan , China, in December 2019. Most scientists believe

Massachusetts Correctional Institution – Concord - Misplaced Pages Continue

3906-722: The Concord Reformatory to put down the uprising. On February 15, 1976, 60 to 80 inmates caused $ 1 million worth of damage to three buildings during a four hour riot that ended when the inmates voluntarily surrendered. Pursuant to the Supreme Judicial Court’s April 3, 2020 Opinion and Order in the Committee for Public Counsel Services v. Chief Justice of the Trial Court, SJC-12926 matter, as amended on April 10, April 28 and June 23, 2020 (the “Order”),

3999-581: The Concord grape") Concord grape spread worldwide, bringing him up to $ 1,000 a cutting, but he died a relatively poor man. The inscription on his tombstone reads, "He sowed—others reaped." On September 5, 2012, Concord became the first community in the United States to approve a ban on the sale of water in single-serving plastic bottles. The law banned the sale of PET bottles of one liter (34 U.S. fl oz) or less starting January 1, 2013. The ban provoked national controversy. An editorial in

4092-645: The Judicial branch of our tripartite system, Commissioner Hogan abolished the Maximum Security Reformatory for men at MCI-Concord and made it a medium security facility that would also be used as a "reception and diagnostic center" which was at MCI-Norfolk already for offenders sentenced to the Maximum Security State Prison Sentence. Before 1978-80 Concord had never housed any State sentenced inmates, so

4185-523: The Massachusetts reformatory. In 1955, because of overcrowding at the State Prison in Charlestown and rioting inmates, Governor Herter formed a committee to study the system and it was decided to revamp the entire State Prison system and the Commissioner was ordered to purchase more prison facilities for those sentenced to the State Prison; to ease the overcrowding situation at Charlestown. During

4278-530: The SARS-CoV-2 virus entered into human populations through natural zoonosis , similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Social and environmental factors including climate change , natural ecosystem destruction and wildlife trade increased the likelihood of such zoonotic spillover . The disease quickly spread worldwide, resulting in

4371-618: The Special Master posted weekly reports for COVID-19 testing and cases for each of the correctional facilities administered by the Department of Correction and each of the county Sheriffs’ offices. Prisoner and staff vaccinations started in the spring of 2021. Weekly reported was stopped in the summer of 2021 and the website terminated. There had been 296 prisoners testing positive and two deaths at MCI-Concord before reporting ended. On January 24, 2024, Governor Healey announced that

4464-475: The WHO declared that another distinctive variant, JN.1, had emerged as a "variant of interest". Though the WHO expected an increase in cases globally, particularly for countries entering winter, the overall global health risk was considered low. The SARS-CoV-2 virus can infect a wide range of cells and systems of the body. COVID‑19 is most known for affecting the upper respiratory tract (sinuses, nose, and throat) and

4557-759: The WHO on 11 February 2020 with COVID-19 being shorthand for "coronavirus disease 2019". The WHO additionally uses "the COVID‑19 virus" and "the virus responsible for COVID‑19" in public communications. The symptoms of COVID-19 are variable depending on the type of variant contracted, ranging from mild symptoms to a potentially fatal illness. Common symptoms include coughing , fever , loss of smell (anosmia) and taste (ageusia), with less common ones including headaches , nasal congestion and runny nose , muscle pain , sore throat , diarrhea , eye irritation , and toes swelling or turning purple, and in moderate to severe cases, breathing difficulties . People with

4650-551: The WHO recommended the labelling of variants using letters of the Greek alphabet , for example, Alpha , Beta , Delta , and Gamma , giving the justification that they "will be easier and more practical to discussed by non-scientific audiences". Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR). The Pango tool groups variants into lineages , with many circulating lineages being classed under

4743-538: The adjacent Orchard House in 1858. Hawthorne dubbed the house "The Wayside" and lived there until his death. The house was purchased in 1883 by Boston publisher Daniel Lothrop and his wife, Harriett, who wrote the Five Little Peppers series and other children's books under the pen name Margaret Sidney . Today, The Wayside and the Orchard House are both museums. Emerson, Thoreau, Hawthorne, and

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4836-480: The age of 18 living with them, 62.98% were married couples living together, 22.4% had a female householder with no spouse present, 12.4% had a male householder with no spouse present, and 28.42% were non-families, and 24.59% of all households were made up of individuals. The average family size was 3.18. 25.1% of the population were under the age of 18, 4.2% from 18 to 24, 25.8% from 25 to 44, 28.4% from 45 to 64, and 16.5% who were 65 years of age or older. The median age

4929-403: The ban have failed in open town meetings . An effort to repeal Concord's ban on the sale of plastic water bottles was resoundingly defeated at a Town Meeting. Resident Jean Hill, who led the initial fight for the ban, said, "I really feel at the age of 86 that I've really accomplished something." Town Moderator Eric Van Loon didn't even bother taking an official tally because opposition to repeal

5022-515: The brain connected to the sense of smell compared with uninfected individuals, and the overall effect on the brain was equivalent on average to at least one extra year of normal ageing; infected individuals also scored lower on several cognitive tests. All effects were more pronounced among older ages. The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric , duodenal and rectal epithelium as well as endothelial cells and enterocytes of

5115-591: The brain found as complications leading to death in people infected with COVID‑19. Infection may initiate a chain of vasoconstrictive responses within the body, including pulmonary vasoconstriction – a possible mechanism in which oxygenation decreases during pneumonia. Furthermore, damage of arterioles and capillaries was found in brain tissue samples of people who died from COVID‑19. COVID‑19 may also cause substantial structural changes to blood cells , sometimes persisting for months after hospital discharge. A low level of blood lymphocytess may result from

5208-428: The brains of those who have died from COVID‑19, but these results need to be confirmed. While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain. The virus may also enter the bloodstream from the lungs and cross the blood–brain barrier to gain access to

5301-409: The clear jelly liquid found in lung autopsies of people who died of COVID-19. One possibility addressed in medical research is that hyuralonic acid (HA) could be the leading factor for this observation of the clear jelly liquid found in the lungs, in what could be hyuralonic storm, in conjunction with cytokine storm . One common symptom, loss of smell, results from infection of the support cells of

5394-406: The data. Of people who show symptoms, 81% develop only mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging) that require hospitalization, and 5% of patients develop critical symptoms ( respiratory failure , septic shock , or multiorgan dysfunction ) requiring ICU admission. At least a third of

5487-721: The expression of ACE-2, thereby facilitating the SARS-Cov2 virus to enter cells and to replicate. A competition of negative feedback loops (via protective effects of interferon alpha) and positive feedback loops (via upregulation of ACE-2) is assumed to determine the fate of patients suffering from COVID-19. Additionally, people with COVID‑19 and acute respiratory distress syndrome (ARDS) have classical serum biomarkers of CRS, including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer , and ferritin . Systemic inflammation results in vasodilation , allowing inflammatory lymphocytic and monocytic infiltration of

5580-428: The eyes, nose, or mouth. The risk is highest when people are in close proximity, but small airborne particles containing the virus can remain suspended in the air and travel over longer distances, particularly indoors. Transmission can also occur when people touch their eyes, nose or mouth after touching surfaces or objects that have been contaminated by the virus. People remain contagious for up to 20 days and can spread

5673-525: The face. While drugs have been developed to inhibit the virus, the primary treatment is still symptomatic , managing the disease through supportive care , isolation , and experimental measures . During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus", with the disease sometimes called "Wuhan pneumonia". In the past, many diseases have been named after geographical locations, such as

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5766-426: The first community in the United States to ban single-serving PET bottles. The area which became the town of Concord was originally known as "Musketaquid", situated at the confluence of the Sudbury and Assabet rivers. The name was an Algonquian word for "grassy plain", fitting the area's low-lying marshes and kettle holes . Native Americans had cultivated corn crops there; the rivers were rich with fish and

5859-523: The heart. ACE2 receptors are highly expressed in the heart and are involved in heart function. A high incidence of thrombosis and venous thromboembolism occurs in people transferred to intensive care units with COVID‑19 infections, and may be related to poor prognosis. Blood vessel dysfunction and clot formation (as suggested by high D-dimer levels caused by blood clots) may have a significant role in mortality, incidents of clots leading to pulmonary embolisms , and ischaemic events (strokes) within

5952-503: The host cell. Following viral entry, COVID‑19 infects the ciliated epithelium of the nasopharynx and upper airways. Autopsies of people who died of COVID‑19 have found diffuse alveolar damage , and lymphocyte-containing inflammatory infiltrates within the lung. From the CT scans of COVID-19 infected lungs, white patches were observed containing fluid known as ground-glass opacity (GGO) or simply ground glass. This tended to correlate with

6045-495: The ideal grape. Early ripening, to escape the killing northern frosts, but with a rich, full-bodied flavor, the hardy Concord grape thrives where European cuttings had failed to survive. In 1853, Bull felt ready to put the first bunches of Concord grapes before the public and won a prize at the Boston Horticultural Society Exhibition. From these early arbors, the fame of Bull's ("the father of

6138-528: The infection, children may develop paediatric multisystem inflammatory syndrome , which has symptoms similar to Kawasaki disease , which can be fatal. In very rare cases, acute encephalopathy can occur, and it can be considered in those who have been diagnosed with COVID‑19 and have an altered mental status. According to the US Centers for Disease Control and Prevention , pregnant women are at increased risk of becoming seriously ill from COVID‑19. This

6231-531: The land was lush and arable. The area was largely depopulated in 1633 by an epidemic of smallpox , a disease likely to have been introduced to the New World by European explorers and settlers. In 1635, a group of English settlers led by Rev. Peter Bulkley and Major Simon Willard received a land grant from the General Court and negotiated a land purchase with the local indigenous tribes . Bulkeley

6324-454: The lower respiratory tract (windpipe and lungs). The lungs are the organs most affected by COVID‑19 because the virus accesses host cells via the receptor for the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant on the surface of type II alveolar cells of the lungs. The virus uses a special surface glycoprotein called a " spike " to connect to the ACE2 receptor and enter

6417-409: The lung and the heart. In particular, pathogenic GM-CSF-secreting T cells were shown to correlate with the recruitment of inflammatory IL-6-secreting monocytes and severe lung pathology in people with COVID‑19. Lymphocytic infiltrates have also been reported at autopsy. Multiple viral and host factors affect the pathogenesis of the virus. The S-protein , otherwise known as the spike protein,

6510-465: The maximum security reformatory facility did their classification in the building designated as the "New Line" where it was decided whether the reformatory inmate would stay at the maximum security reformatory or be moved to the Farm across the street. Since June 2009 MCI-Concord was redesignated as a medium security facility of the State Prison and Massachusetts. Timothy Leary 's Concord Prison Experiment

6603-438: The mid-19th century, centered around Ralph Waldo Emerson . Emerson's circle included Nathaniel Hawthorne , Louisa May Alcott and Henry David Thoreau . Major works written in Concord during this period include Alcott's novel Little Women , Emerson's essay Self-Reliance , and Thoreau's Walden and Civil Disobedience . In this era, the now-ubiquitous Concord grape was developed in Concord by Ephraim Wales Bull . In

6696-447: The moment a person first becomes infected and the appearance of the first symptoms. The median delay for COVID-19 is four to five days possibly being infectious on 1–4 of those days. Most symptomatic people experience symptoms within two to seven days after exposure, and almost all will experience at least one symptom within 12 days. Most people recover from the acute phase of the disease. However, some people continue to experience

6789-509: The now-ubiquitous Concord grape at his home on Lexington Road, where the original vine still grows. Welch's , the first company to sell grape juice, maintains a headquarters in Concord. The Boston-born Bull developed the Concord grape by experimenting with seeds from some of the native species. On his farm outside Concord, down the road from the Emerson, Thoreau, Hawthorne and Alcott homesteads, he planted some 22,000 seedlings before producing

6882-480: The olfactory epithelium , with subsequent damage to the olfactory neurons . The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. It is clear that many people with COVID-19 exhibit neurological or mental health issues . The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues . However, SARS-CoV-2 has been detected at low levels in

6975-536: The peaceful acquisition. The battles of Lexington and Concord were the first military engagements of the American Revolutionary War . On April 19, 1775, 700 British Army troops led by Lieutenant-Colonel Francis Smith marched from Boston to Concord to confiscate a cache of arms stored in the town. Unbeknownst to them, Patriot leaders had moved most of the cache elsewhere. 150 Patriot minutemen from local towns, who had been forewarned of

7068-488: The peak viral load in upper respiratory tract samples occurs close to the time of symptom onset and declines after the first week after symptoms begin. Current evidence suggests a duration of viral shedding and the period of infectiousness of up to ten days following symptom onset for people with mild to moderate COVID-19, and up to 20 days for persons with severe COVID-19, including immunocompromised people. Severe acute respiratory syndrome coronavirus   2 (SARS-CoV-2)

7161-411: The people who are infected with the virus do not develop noticeable symptoms at any point in time. These asymptomatic carriers tend not to get tested and can still spread the disease. Other infected people will develop symptoms later (called "pre-symptomatic") or have very mild symptoms and can also spread the virus. As is common with infections, there is a delay, or incubation period , between

7254-673: The philosopher Amos Bronson Alcott (1799–1888), the father of Louisa May Alcott (1832–1888). A native Concordian, Henry David Thoreau (1817–1862) was another notable member of Emerson's circle. This substantial collection of literary talent in one small town led Henry James to dub Concord "the biggest little place in America." Among the products of this intellectually stimulating environment were Emerson's many essays, including Self-Reliance (1841), Louisa May Alcott's novel Little Women (1868), and Hawthorne's story collection Mosses from an Old Manse (1846). Thoreau famously lived in

7347-504: The population had grown to 1,400. As dissension between colonists in North America and the British crown intensified, 700 troops were sent to confiscate militia ordnance stored at Concord on April 19, 1775. The ensuing conflict, the battles of Lexington and Concord , were the incidents (including the shot heard round the world ) that triggered the American Revolutionary War . A rich literary community developed in Concord during

7440-517: The reformatory did not stop until the reformatory sentence was repealed in 1994. Around 1978–80, after a major riot at the reformatory, where the inmates even robbed the prison Canteen Store, during a movie, Dog Day Afternoon held in the Gym (where all the inmates go at one time) over 150 reformatory inmates were transferred to the State Prison, and 150 State inmates were transferred to the reformatory. Then, without Legislative authority, or even notifying

7533-416: The respiratory tract, people with severe COVID‑19 have symptoms of systemic hyperinflammation. Clinical laboratory findings of elevated IL‑2 , IL‑6 , IL‑7 , as well as the following suggest an underlying immunopathology: Interferon alpha plays a complex, Janus-faced role in the pathogenesis of COVID-19. Although it promotes the elimination of virus-infected cells, it also upregulates

7626-859: The risk of long COVID includes staying up to date on the most recent COVID-19 vaccine, practicing good hygiene, maintaining clean indoor air, and physical distancing from people infected with a respiratory virus. Complications may include pneumonia , acute respiratory distress syndrome (ARDS), multi-organ failure , septic shock , and death. Cardiovascular complications may include heart failure, arrhythmias (including atrial fibrillation ), heart inflammation , thrombosis , particularly venous thromboembolism , and endothelial cell injury and dysfunction. Approximately 20–30% of people who present with COVID‑19 have elevated liver enzymes , reflecting liver injury. Neurologic manifestations include seizure , stroke, encephalitis , and Guillain–Barré syndrome (which includes loss of motor functions ). Following

7719-469: The state Department of Corrections planned to close the prison by summertime, citing a decline in the statewide prison population and an effort to curb state spending in the face of declining tax revenues. The facility officially closed on July 17, 2024. Concord, Massachusetts Concord ( / ˈ k ɒ ŋ k ər d / ) is a town in Middlesex County, Massachusetts , United States. In

7812-561: The town: his father, Rev. William Emerson (1769–1811), grew up in Concord before becoming an eminent Boston minister, and his grandfather, William Emerson Sr. , witnessed the battle at the North Bridge from his house, and later became a chaplain in the Continental Army. Emerson was at the center of a group of like-minded Transcendentalists living in Concord. Among them were the author Nathaniel Hawthorne (1804–1864) and

7905-516: The virus acting through ACE2-related entry into lymphocytes. Another common cause of death is complications related to the kidneys . Early reports show that up to 30% of hospitalised patients both in China and in New York have experienced some injury to their kidneys, including some persons with no previous kidney problems. Although SARS-CoV-2 has a tropism for ACE2-expressing epithelial cells of

7998-752: The virus even if they do not develop symptoms. Testing methods for COVID-19 to detect the virus's nucleic acid include real-time reverse transcription polymerase chain reaction (RT‑PCR), transcription-mediated amplification , and reverse transcription loop-mediated isothermal amplification (RT‑LAMP) from a nasopharyngeal swab . Several COVID-19 vaccines have been approved and distributed in various countries, many of which have initiated mass vaccination campaigns . Other preventive measures include physical or social distancing , quarantining , ventilation of indoor spaces, use of face masks or coverings in public, covering coughs and sneezes, hand washing , and keeping unwashed hands away from

8091-509: The virus is carried out through virus-laden fluid particles, or droplets, which are created in the respiratory tract, and they are expelled by the mouth and the nose. There are three types of transmission: "droplet" and "contact", which are associated with large droplets, and "airborne", which is associated with small droplets. If the droplets are above a certain critical size, they settle faster than they evaporate , and therefore they contaminate surfaces surrounding them. Droplets that are below

8184-433: Was 42 years. For every 100 females, there were 100.3 males. For every 100 women aged 18 and over, there were 101.8 men. At the time of the 2020 census , the median household income was $ 184,086. About 2.5% of the population was below the poverty line, including 1.7% of those under age 18 and 1.1% of those aged 65 or over. The town's name is pronounced by its residents as / ˈ k ɒ ŋ k ər d / KONG -kərd , in

8277-760: Was also the home to the department's Central Date Computation Unit, Central Records Unit, Central Research Unit, and the Data Collection Unit. All of which were split between the SFU Building outside and B-Building within the walls of the facility. MCI Concord opened in May 1878 as the New State Prison at Concord with Mexican War veteran General Chamberlain as its warden. In 1884, all the State inmates were taken out of Concord and transferred to

8370-496: Was an influential religious leader who "carried a good number of planters with him into the woods"; Willard was a canny trader who spoke the Algonquian language and had gained the trust of Native Americans. They exchanged wampum , hatchets, knives, cloth, and other useful items for the six-square-mile (16 km ) purchase from Squaw Sachem of Mistick , which formed the basis of the new town, called "Concord" in appreciation of

8463-486: Was conducted at MCI Concord during the early 1960s. In early July, 1882 at 12:00 midnight inmates at the Concord Reformatory began to cause a disturbance by shouting and banging on doors. The noise went on for hours and the prison's warden decided to punish the inmates by revoking their yard privileges for July 4. This caused the disturbance to escalate with inmates breaking down wooden doors and furniture being destroyed. The riot stopped three days later. On April 22, 1959,

8556-406: Was so overwhelming. It appeared that upwards of 80 to 90 percent of the 1,127 voters in attendance raised their ballots against the repeal measure. The issue had been bubbling in Concord for several years. In 2010, a ban approved in a town meeting, which wasn't written as a bylaw, was rejected by the state attorney general's office. In 2011, a new version of the ban narrowly failed at a town meeting by

8649-407: Was subject to termination if the parolee proved to be rehabilitated. The courts sentenced those they felt could be reformed to the reformatory, and the more serious offenders to the State prison. Programs were set up at Concord so that the offender could prove himself reformed, and be paroled could learn a trade to be used on their return to society. In 1893, additional construction added 230 cells to

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