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146-479: Chihuahuita's history dates back over 400 years. Prior to European arrival, Manso Indians lived on the land. The first European in the area was Francisco Sanchez who introduced horses and other livestock to the area in 1581. A Spanish explorer who visited Chihuahuita called it Los Vueltos del Rio , or Turns of the River in 1583. A Catholic missionary, Fray Alonso de Benavides attempted and failed to convert

292-871: A German naturalist, Peter Simon Pallas , as a valley that once connected the Black Sea and the Caspian Sea, and subsequently was proposed as a natural boundary between continents. By the mid-19th century, there were three main conventions, one following the Don, the Volga–Don Canal and the Volga, the other following the Kuma–Manych Depression to the Caspian and then the Ural River, and the third abandoning

438-643: A Semitic term for west , this being either Akkadian erebu meaning 'to go down, set' (said of the sun) or Phoenician 'ereb 'evening, west', which is at the origin of Arabic maghreb and Hebrew ma'arav . Martin Litchfield West stated that "phonologically, the match between Europa's name and any form of the Semitic word is very poor", while Beekes considers a connection to Semitic languages improbable. Most major world languages use words derived from Eurṓpē or Europa to refer to

584-435: A biochemical target, compounds described in patents or literature, or biocontrol organisms. Compounds that are active in the screening process, known as hits or leads, cannot be used as pesticides, except for biocontrol organisms and some potent natural products. These lead compounds need to be optimised by a series of cycles of synthesis and testing of analogs. For approval by regulatory authorities for use as pesticides,

730-818: A boundary along the Terek and Kuban rivers, so southwards from the Kuma and the Manych, but still with the Caucasus entirely in Asia. However, most geographers in the Soviet Union favoured the boundary along the Caucasus crest, and this became the common convention in the later 20th century, although the Kuma–Manych boundary remained in use in some 20th-century maps. Some view the separation of Eurasia into Asia and Europe as

876-582: A common currency, the euro , and participate in the European single market and a customs union . A large bloc of countries, the Schengen Area , have also abolished internal border and immigration controls. Regular popular elections take place every five years within the EU; they are considered to be the second-largest democratic elections in the world after India's . The EU is the third-largest economy in

1022-406: A large land mass completely or almost completely surrounded by water at its borders. Prior to the adoption of the current convention that includes mountain divides, the border between Europe and Asia had been redefined several times since its first conception in classical antiquity , but always as a series of rivers, seas and straits that were believed to extend an unknown distance east and north from

1168-552: A mile in size. A historical survey of the area is planned to take place in 2017. Historically Mexicans settled in Chihuahuita. In 1920, 95% of residents were Mexican and in 1930, 97% had Mexican roots. Currently (as of 2017) around 100 families live in the area. City plans for Chihuahuita included parks and swimming areas in 1912. Census records for 1910 showed that nearly half of all school-aged children in El Paso lived in

1314-538: A pesticide is a chemical or biological agent (such as a virus , bacterium , or fungus ) that deters, incapacitates, kills, or otherwise discourages pests. Target pests can include insects, plant pathogens , weeds, molluscs , birds , mammals , fish , nematodes (roundworms), and microbes that destroy property, cause nuisance, or spread disease, or are disease vectors . Along with these benefits, pesticides also have drawbacks, such as potential toxicity to humans and other species. The word pesticide derives from

1460-401: A pesticide was first seen in the 1920s with inorganic pesticides, and later it was found that development of resistance is to be expected, and measures to delay it are important. Integrated pest management (IPM) was introduced in the 1950s. By careful analysis and spraying only when an economical or biological threshold of crop damage is reached, pesticide application is reduced. This became in

1606-763: A precise eastern boundary of Europe arises in the Early Modern period, as the eastern extension of Muscovy began to include North Asia . Throughout the Middle Ages and into the 18th century, the traditional division of the landmass of Eurasia into two continents, Europe and Asia, followed Ptolemy, with the boundary following the Turkish Straits , the Black Sea , the Kerch Strait , the Sea of Azov and

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1752-711: A residue of Eurocentrism : "In physical, cultural and historical diversity, China and India are comparable to the entire European landmass, not to a single European country. [...]." During the 2.5 million years of the Pleistocene , numerous cold phases called glacials ( Quaternary ice age ), or significant advances of continental ice sheets, in Europe and North America, occurred at intervals of approximately 40,000 to 100,000 years. The long glacial periods were separated by more temperate and shorter interglacials which lasted about 10,000–15,000 years. The last cold episode of

1898-685: A result, the Reconquista took the greater part of eight hundred years, in which period a long list of Alfonsos, Sanchos, Ordoños, Ramiros, Fernandos, and Bermudos would be fighting their Christian rivals as much as the Muslim invaders. During the Dark Ages, the Western Roman Empire fell under the control of various tribes. The Germanic and Slav tribes established their domains over Western and Eastern Europe, respectively. Eventually

2044-743: Is a continent located entirely in the Northern Hemisphere and mostly in the Eastern Hemisphere . It is bordered by the Arctic Ocean to the north, the Atlantic Ocean to the west, the Mediterranean Sea to the south, and Asia to the east. Europe shares the landmass of Eurasia with Asia, and of Afro-Eurasia with both Asia and Africa . Europe is commonly considered to be separated from Asia by

2190-401: Is also evidence that Homo sapiens arrived in Europe around 54,000 years ago, some 10,000 years earlier than previously thought. The earliest sites in Europe dated 48,000 years ago are Riparo Mochi (Italy), Geissenklösterle (Germany) and Isturitz (France). The European Neolithic period—marked by the cultivation of crops and the raising of livestock, increased numbers of settlements and

2336-455: Is becoming widespread and has been used with success in countries such as Indonesia , China , Bangladesh , the U.S., Australia , and Mexico . IPM attempts to recognize the more widespread impacts of an action on an ecosystem , so that natural balances are not upset. Each use of a pesticide carries some associated risk. Proper pesticide use decreases these associated risks to a level deemed acceptable by pesticide regulatory agencies such as

2482-488: Is closest to Anatolia (or Asia Minor), but is considered part of Europe politically and it is a member state of the EU. Malta was considered an island of North-western Africa for centuries, but now it is considered to be part of Europe as well. "Europe", as used specifically in British English , may also refer to Continental Europe exclusively. The term "continent" usually implies the physical geography of

2628-562: Is generally considered a transcontinental country divided entirely by water, while Russia and Kazakhstan are only partly divided by waterways. France, the Netherlands, Portugal and Spain are also transcontinental (or more properly, intercontinental, when oceans or large seas are involved) in that their main land areas are in Europe while pockets of their territories are located on other continents separated from Europe by large bodies of water. Spain, for example, has territories south of

2774-456: Is similarly challenging, yet well documented in developing countries. Because of critical development periods of the fetus and newborn children, these non-working populations are more vulnerable to the effects of pesticides, and may be at increased risk of developing neurocognitive effects and impaired development. While measuring biomarkers or markers of biological effects may provide more accurate estimates of exposure, collecting these data in

2920-550: Is sometimes considered to mark the end of antiquity; alternatively antiquity is considered to end with the fall of the Western Roman Empire in 476 CE; the closure of the pagan Platonic Academy of Athens in 529 CE; or the rise of Islam in the early 7th century CE. During most of its existence, the Byzantine Empire was one of the most powerful economic, cultural, and military forces in Europe. During

3066-422: Is somewhat arbitrary and inconsistent compared to any clear-cut definition of the term "continent". The current division of Eurasia into two continents now reflects East-West cultural, linguistic and ethnic differences which vary on a spectrum rather than with a sharp dividing line. The geographic border between Europe and Asia does not follow any state boundaries and now only follows a few bodies of water. Turkey

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3212-474: Is substantial evidence of associations between organophosphate insecticide exposures and neurobehavioral alterations. Limited evidence also exists for other negative outcomes from pesticide exposure including neurological, birth defects , and fetal death . The American Academy of Pediatrics recommends limiting exposure of children to pesticides and using safer alternatives: Pesticides are also found in majority of U.S. households with 88 million out of

3358-477: Is the largest and most populous , spanning 39% of the continent and comprising 15% of its population. Europe had a total population of about 745 million (about 10% of the world population ) in 2021; the third-largest after Asia and Africa. The European climate is affected by warm Atlantic currents, such as the Gulf Stream , which produce a temperate climate , tempering winters and summers, on much of

3504-593: Is the oldest area of El Paso. It is located in the southernmost area of the city and is between downtown El Paso and the rail yards . It lies along the Mexico-United States border . When the city designated it as a historic district, the boundaries of the neighborhood included Canal Street on the north, the Franklin Canal in the south and Santa Fe Street to the East. The area is around a quarter of

3650-504: Is to find new compounds or agents with improved properties such as a new mode of action or lower application rate. Another aim is to replace older pesticides which have been banned for reasons of toxicity or environmental harm or have become less effective due to development of resistance . The process starts with testing (screening) against target organisms such as insects , fungi or plants . Inputs are typically random compounds, natural products , compounds designed to disrupt

3796-483: Is widespread in Latin America , as around US$ 3 billion are spent each year in the region. Records indicate an increase in the frequency of pesticide poisonings over the past two decades. The most common incidents of pesticide poisoning is thought to result from exposure to organophosphate and carbamate insecticides. At-home pesticide use, use of unregulated products, and the role of undocumented workers within

3942-845: The Carolingian Renaissance of the 9th century. From that time, the term designated the sphere of influence of the Western Church , as opposed to both the Eastern Orthodox churches and to the Islamic world . A cultural definition of Europe as the lands of Latin Christendom coalesced in the 8th century, signifying the new cultural condominium created through the confluence of Germanic traditions and Christian-Latin culture, defined partly in contrast with Byzantium and Islam , and limited to northern Iberia ,

4088-517: The Don (ancient Tanais ). But maps produced during the 16th to 18th centuries tended to differ in how to continue the boundary beyond the Don bend at Kalach-na-Donu (where it is closest to the Volga, now joined with it by the Volga–Don Canal ), into territory not described in any detail by the ancient geographers. Around 1715, Herman Moll produced a map showing the northern part of the Ob River and

4234-573: The European population at the time. The plague had a devastating effect on Europe's social structure; it induced people to live for the moment as illustrated by Giovanni Boccaccio in The Decameron (1353). It was a serious blow to the Roman Catholic Church and led to increased persecution of Jews , beggars and lepers . The plague is thought to have returned every generation with varying virulence and mortalities until

4380-512: The Greeks and Phoenicians gave rise to early Mediterranean cities. Early Iron Age Italy and Greece from around the 8th century BCE gradually gave rise to historical Classical antiquity, whose beginning is sometimes dated to 776 BCE, the year of the first Olympic Games . Ancient Greece was the founding culture of Western civilisation. Western democratic and rationalist culture are often attributed to Ancient Greece. The Greek city-state,

4526-636: The Inquisition against heretics. In the Iberian Peninsula , the Reconquista concluded with the fall of Granada in 1492 , ending over seven centuries of Islamic rule in the south-western peninsula. In the east, a resurgent Byzantine Empire recaptured Crete and Cyprus from the Muslims, and reconquered the Balkans. Constantinople was the largest and wealthiest city in Europe from the 9th to

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4672-801: The Iron Curtain , with NATO in the West and the Warsaw Pact in the East . This divide ended with the Revolutions of 1989 , the fall of the Berlin Wall , and the dissolution of the Soviet Union , which allowed European integration to advance significantly. European integration is being advanced institutionally since 1948 with the founding of the Council of Europe , and significantly through

4818-733: The Irtysh River , a major tributary of the Ob, as components of a series of partly-joined waterways taking the boundary between Europe and Asia from the Turkish Straits, and the Don River all the way to the Arctic Ocean. In 1721, he produced a more up to date map that was easier to read. However, his proposal to adhere to major rivers as the line of demarcation was never taken up by other geographers who were beginning to move away from

4964-479: The Mediterranean Sea —namely, Ceuta and Melilla —which are parts of Africa and share a border with Morocco. According to the current convention, Georgia and Azerbaijan are transcontinental countries where waterways have been completely replaced by mountains as the divide between continents. The first recorded usage of Eurṓpē as a geographic term is in the Homeric Hymn to Delian Apollo , in reference to

5110-708: The Megalithic Temples of Malta and Stonehenge , were constructed throughout Western and Southern Europe. The modern native populations of Europe largely descend from three distinct lineages: Mesolithic hunter-gatherers , descended from populations associated with the Paleolithic Epigravettian culture; Neolithic Early European Farmers who migrated from Anatolia during the Neolithic Revolution 9,000 years ago; and Yamnaya Steppe herders who expanded into Europe from

5256-607: The Neandertal valley in Germany ) appeared in Europe 150,000 years ago (115,000 years ago it is found already in the territory of present-day Poland ) and disappeared from the fossil record about 40,000 years ago, with their final refuge being the Iberian Peninsula. The Neanderthals were supplanted by modern humans ( Cro-Magnons ), who seem to have appeared in Europe around 43,000 to 40,000 years ago. However, there

5402-655: The Pechenegs and the Cuman-Kipchaks , caused a massive migration of Slavic populations to the safer, heavily forested regions of the north, and temporarily halted the expansion of the Rus' state to the south and east. Like many other parts of Eurasia , these territories were overrun by the Mongols . The invaders, who became known as Tatars , were mostly Turkic-speaking peoples under Mongol suzerainty. They established

5548-693: The Pontic–Caspian steppe of Ukraine and southern Russia in the context of Indo-European migrations 5,000 years ago. The European Bronze Age began c. 3200 BCE in Greece with the Minoan civilisation on Crete , the first advanced civilisation in Europe. The Minoans were followed by the Myceneans , who collapsed suddenly around 1200 BCE, ushering the European Iron Age . Iron Age colonisation by

5694-630: The Serbian Principality (later Kingdom and Empire ), and the Duchy of Croatia (later Kingdom of Croatia ). To the east, Kievan Rus' expanded from its capital in Kiev to become the largest state in Europe by the 10th century. In 988, Vladimir the Great adopted Orthodox Christianity as the religion of state. Further east, Volga Bulgaria became an Islamic state in the 10th century, but

5840-598: The UN Environment Programme estimate that 3 million agricultural workers in the developing world experience severe poisoning from pesticides each year, resulting in 18,000 deaths. According to one study, as many as 25 million workers in developing countries may suffer mild pesticide poisoning yearly. Other occupational exposures besides agricultural workers, including pet groomers, groundskeepers , and fumigators , may also put individuals at risk of health effects from pesticides. Pesticide use

5986-624: The United States Environmental Protection Agency (EPA) and the Pest Management Regulatory Agency (PMRA) of Canada. DDT , sprayed on the walls of houses, is an organochlorine that has been used to fight malaria vectors (mosquitos) since the 1940s. The World Health Organization recommend this approach. It and other organochlorine pesticides have been banned in most countries worldwide because of their persistence in

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6132-545: The decline of the Roman Empire , Europe entered a long period of change arising from what historians call the " Age of Migrations ". There were numerous invasions and migrations amongst the Ostrogoths , Visigoths , Goths , Vandals , Huns , Franks , Angles , Saxons , Slavs , Avars , Bulgars , Vikings , Pechenegs , Cumans , and Magyars . Renaissance thinkers such as Petrarch would later refer to this as

6278-434: The environment or the food chain in order to be approved by the authorities. Persistent pesticides, including DDT , were banned many years ago , an exception being spraying in houses to combat malaria vectors . From biblical times until the 1950s the pesticides used were inorganic compounds and plant extracts . The inorganic compounds were derivatives of copper , arsenic , mercury, sulfur , among others, and

6424-465: The fall of the Western Roman Empire in 476 CE, Christian consolidation of Europe in the wake of the Migration Period marked the European post-classical Middle Ages . The Italian Renaissance spread in the continent a new humanist interest in art and science which led to the modern era . Since the Age of Discovery , led by Spain and Portugal , Europe played a predominant role in global affairs with multiple explorations and conquests around

6570-429: The insurrectos , or revolutionaries. The majority of Mexicans settled in Chihuahuita because the housing was more affordable there. Poor sanitary conditions in the area were described by the El Paso Herald early on. Physicians, including Dr. Michael P. Schuster, husband of Eugenia Schuster , reported unhealthful conditions and advocated for improved sewage and free garbage pick-up. Many Mexican families put up with

6716-432: The last glacial period ended about 10,000 years ago. Earth is currently in an interglacial period of the Quaternary, called the Holocene . Homo erectus georgicus , which lived roughly 1.8 million years ago in Georgia , is the earliest hominin to have been discovered in Europe. Other hominin remains, dating back roughly 1 million years, have been discovered in Atapuerca , Spain . Neanderthal man (named after

6862-499: The phloem or both. Non-systemic pesticides (contact pesticides) remain on the surface and act through direct contact with the target organism. Pesticides are more effective if they are systemic. Systemicity is a prerequisite for the pesticide to be used as a seed-treatment. Pesticides can be classified as persistent (non-biodegradable) or non-persistent ( biodegradable ). A pesticide must be persistent enough to kill or control its target but must degrade fast enough not to accumulate in

7008-517: The polis , was the fundamental political unit of classical Greece. In 508 BCE, Cleisthenes instituted the world's first democratic system of government in Athens . The Greek political ideals were rediscovered in the late 18th century by European philosophers and idealists. Greece also generated many cultural contributions: in philosophy , humanism and rationalism under Aristotle , Socrates and Plato ; in history with Herodotus and Thucydides ; in dramatic and narrative verse, starting with

7154-457: The watershed of the Ural Mountains , the Ural River , the Caspian Sea , the Greater Caucasus , the Black Sea , and the waterway of the Bosporus Strait . Europe covers about 10.18 million km (3.93 million sq mi), or 2% of Earth's surface (6.8% of land area), making it the second-smallest continent (using the seven-continent model ). Politically, Europe is divided into about fifty sovereign states , of which Russia

7300-402: The "Dark Ages". Isolated monastic communities were the only places to safeguard and compile written knowledge accumulated previously; apart from this, very few written records survive. Much literature, philosophy, mathematics, and other thinking from the classical period disappeared from Western Europe, though they were preserved in the east, in the Byzantine Empire. While the Roman empire in

7446-470: The 121.1 million households indicating that they use some form of pesticide in 2012. As of 2007, there were more than 1,055 active ingredients registered as pesticides, which yield over 20,000 pesticide products that are marketed in the United States. Owing to inadequate regulation and safety precautions, 99% of pesticide-related deaths occur in developing countries that account for only 25% of pesticide usage. One study found pesticide self-poisoning

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7592-461: The 12th centuries, with a population of approximately 400,000. The Empire was weakened following the defeat at Manzikert , and was weakened considerably by the sack of Constantinople in 1204 , during the Fourth Crusade . Although it would recover Constantinople in 1261, Byzantium fell in 1453 when Constantinople was taken by the Ottoman Empire . In the 11th and 12th centuries, constant incursions by nomadic Turkic tribes, such as

7738-401: The 12th to the 15th centuries, the Grand Duchy of Moscow grew from a small principality under Mongol rule to the largest state in Europe, overthrowing the Mongols in 1480, and eventually becoming the Tsardom of Russia . The state was consolidated under Ivan III the Great and Ivan the Terrible , steadily expanding to the east and south over the next centuries. The Great Famine of 1315–1317

7884-913: The 14th and 16th centuries: it saw the flowering of art , philosophy , music , and the sciences , under the joint patronage of royalty , the nobility, the Roman Catholic Church and an emerging merchant class. Patrons in Italy, including the Medici family of Florentine bankers and the Popes in Rome , funded prolific quattrocento and cinquecento artists such as Raphael , Michelangelo and Leonardo da Vinci . Pesticide Pesticides are substances that are used to control pests . They include herbicides , insecticides , nematicides , fungicides , and many others (see table). The most common of these are herbicides, which account for approximately 50% of all pesticide use globally. Most pesticides are used as plant protection products (also known as crop protection products), which in general protect plants from weeds , fungi, or insects . In general,

8030-444: The 18th century. During this period, more than 100 plague epidemics swept across Europe. The Renaissance was a period of cultural change originating in Florence , and later spreading to the rest of Europe. The rise of a new humanism was accompanied by the recovery of forgotten classical Greek and Arabic knowledge from monastic libraries, often translated from Arabic into Latin . The Renaissance spread across Europe between

8176-419: The 1970s and 1980s, Chihuahuita was a "hot spot" for selling and buying heroin and the trade was run by Gilberto Ontiveros, also known as El Greñas. During this time, there was a strong gang in the area known as the Chihuahuita gang. Residents also began to seek historic designation in 1979. The area was designated as a historic district finally in 1991. Many Mexicans used Chihuahuita as a place to cross into

8322-538: The 2000s and less than 40 in the 2010s. Biopesticides are cheaper to develop, since the authorities require less toxicological and environmental study. Since 2000 the rate of new biological product introduction has frequently exceeded that of conventional products. More than 25% of existing chemical pesticides contain one or more chiral centres (stereogenic centres). Newer pesticides with lower application rates tend to have more complex structures, and thus more often contain chiral centres. In cases when most or all of

8468-456: The 2020s the official policy of international organisations, industry, and many governments. With the introduction of high yielding varieties in the 1960s in the green revolution , more pesticides were used. Since the 1980s genetically modified crops were introduced, which resulted in lower amounts of insecticides used on them. Organic agriculture, which uses only non-synthetic pesticides, has grown and in 2020 represents about 1.5 per cent of

8614-400: The 50 years of peace that followed are known as Golden Age of Athens , the seminal period of ancient Greece that laid many of the foundations of Western civilisation. Greece was followed by Rome , which left its mark on law , politics , language , engineering , architecture , government , and many more key aspects in western civilisation. By 200 BCE, Rome had conquered Italy and over

8760-421: The British Isles, France, Christianised western Germany, the Alpine regions and northern and central Italy. The concept is one of the lasting legacies of the Carolingian Renaissance : Europa often figures in the letters of Charlemagne's court scholar, Alcuin . The transition of Europe to being a cultural term as well as a geographic one led to the borders of Europe being affected by cultural considerations in

8906-448: The Chihuahuita district. Recreational areas were proposed in 1922, and considered a priority by George E. Kessler , a landscape engineer . The area he recommended consisted of two blocks next to Aoy School in the neighborhood and would include a playground and general recreation area. Chihuahuita Recreation Center on Charles Street offers sports and summer camps for youth. It was first opened in 1981. Europe Europe

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9052-448: The Don altogether, following the Greater Caucasus watershed to the Caspian. The question was still treated as a "controversy" in geographical literature of the 1860s, with Douglas Freshfield advocating the Caucasus crest boundary as the "best possible", citing support from various "modern geographers". In Russia and the Soviet Union , the boundary along the Kuma–Manych Depression was the most commonly used as early as 1906. In 1958,

9198-427: The Early Middle Ages, and soon spread throughout Europe. A struggle for influence between the nobility and the monarchy in England led to the writing of Magna Carta and the establishment of a parliament . The primary source of culture in this period came from the Roman Catholic Church . Through monasteries and cathedral schools , the Church was responsible for education in much of Europe. The Papacy reached

9344-452: The East, especially relating to areas under Byzantine, Ottoman, and Russian influence. Such questions were affected by the positive connotations associated with the term Europe by its users. Such cultural considerations were not applied to the Americas, despite their conquest and settlement by European states. Instead, the concept of "Western civilization" emerged as a way of grouping together Europe and these colonies. The question of defining

9490-421: The Frankish tribes were united under Clovis I . Charlemagne , a Frankish king of the Carolingian dynasty who had conquered most of Western Europe, was anointed " Holy Roman Emperor " by the Pope in 800. This led in 962 to the founding of the Holy Roman Empire , which eventually became centred in the German principalities of central Europe. East Central Europe saw the creation of the first Slavic states and

9636-404: The Great 's efforts to make Russia more European, ignored the whole boundary question with his claim that neither Russia, Scandinavia, northern Germany, nor Poland were fully part of Europe. Since then, many modern analytical geographers like Halford Mackinder have declared that they see little validity in the Ural Mountains as a boundary between continents. The mapmakers continued to differ on

9782-519: The Latin pestis (plague) and caedere (kill). The Food and Agriculture Organization (FAO) has defined pesticide as: Pesticides can be classified by target organism (e.g., herbicides , insecticides , fungicides , rodenticides , and pediculicides – see table), Biopesticides according to the EPA include microbial pesticides, biochemical pesticides, and plant-incorporated protectants. Pesticides can be classified into structural classes, with many structural classes developed for each of

9928-427: The Levant and North Africa and making inroads into Asia Minor . In the mid-7th century, following the Muslim conquest of Persia , Islam penetrated into the Caucasus region. Over the next centuries Muslim forces took Cyprus , Malta , Crete , Sicily , and parts of southern Italy . Between 711 and 720, most of the lands of the Visigothic Kingdom of Iberia were brought under Muslim rule—save for small areas in

10074-423: The Manso to Christianity in 1630. Fray Garcia de San Francisco y Zuniga was more successful in establishing himself in the area. He built a mission, "Nuestra Senora de Guadalupe de los Mansos del Paso del Norte," in 1659 and forced the Manso to dig irrigation ditches and dams in the area. In 1768, residents of the area under the leadership of Don Joseph Sobrado y Horcasitas built a dam called La Presa to help contain

10220-414: The Mediterranean Sea without the inclusion of any mountain ranges. Cartographer Herman Moll suggested in 1715 Europe was bounded by a series of partly-joined waterways directed towards the Turkish straits, and the Irtysh River draining into the upper part of the Ob River and the Arctic Ocean . In contrast, the present eastern boundary of Europe partially adheres to the Ural and Caucasus Mountains, which

10366-465: The Rio Grande in the area which often flooded. In 1818, Ricardo Brusuelas received a land grant from Spain where he developed a ranch. Bruseuelas ranch, once established, encouraged other Mexicans to move to Chihuahuita. The Santa Fe Railroad was built in the area in 1881. In the 1890s, more Mexican people migrated north and the area started to be known as Chihuahuita. Flooding in 1897 was especially severe in Chihuahuita, ruining many homes. A gas plant

10512-563: The Roadblockers took over much of the area. In the 1950s, the streets of Chihuahuita were finally paved. People were still living in tenements "where as many as ten families shared a single toilet and relied on a central hydrant for water," according to Monica Perales. "General clean up" of the area included a "majority of the houses and buildings condemned and destroyed," according to the El Paso Herald-Post in 1964. In

10658-801: The Soviet Geographical Society formally recommended that the boundary between the Europe and Asia be drawn in textbooks from Baydaratskaya Bay , on the Kara Sea , along the eastern foot of Ural Mountains, then following the Ural River until the Mugodzhar Hills , and then the Emba River ; and Kuma–Manych Depression, thus placing the Caucasus entirely in Asia and the Urals entirely in Europe. The Flora Europaea adopted

10804-509: The Tanais (the modern Don River) as the boundary. The Roman Empire did not attach a strong identity to the concept of continental divisions. However, following the fall of the Western Roman Empire , the culture that developed in its place , linked to Latin and the Catholic church, began to associate itself with the concept of "Europe". The term "Europe" is first used for a cultural sphere in

10950-703: The USA (457 kt) was the second-largest user. Applications per cropland area in 2021 varied widely, from 10.9 kg/ hectare in Brazil to 0.8 kg/ha in the Russian Federation. The level in Brazil was about twice as high as in Argentina (5.6 kg/ha) and Indonesia (5.3 kg/ha). Insecticide use in the US has declined by more than half since 1980 (0.6%/yr), mostly due to the near phase-out of organophosphates . In corn fields,

11096-484: The United States to search for work during the 1990s. In 1993, Chief Agent Silvestre Reyes implemented "Operation Blockade," which increased the number of Border Patrol officers in the area. The strategy did decrease the number of illegal crossings in Chihuahuita. Reyes' policy emphasized border security, rather than the number of arrests. The blockade helped residents because gangs in Chihuahuita used to prey on

11242-595: The Workplace". Better understanding of how pesticides elicit their toxic effects is needed before this method of exposure assessment can be applied to occupational exposure of agricultural workers. Alternative methods to assess exposure include questionnaires to discern from participants whether they are experiencing symptoms associated with pesticide poisoning. Self-reported symptoms may include headaches, dizziness, nausea, joint pain, or respiratory symptoms. Multiple challenges exist in assessing exposure to pesticides in

11388-496: The adoption of Christianity ( c. 1000 CE) . The powerful West Slavic state of Great Moravia spread its territory all the way south to the Balkans, reaching its largest territorial extent under Svatopluk I and causing a series of armed conflicts with East Francia . Further south, the first South Slavic states emerged in the late 7th and 8th century and adopted Christianity : the First Bulgarian Empire ,

11534-572: The agricultural industry makes characterizing true pesticide exposure a challenge. It is estimated that 50–80% of pesticide poisoning cases are unreported. Underreporting of pesticide poisoning is especially common in areas where agricultural workers are less likely to seek care from a healthcare facility that may be monitoring or tracking the incidence of acute poisoning. The extent of unintentional pesticide poisoning may be much greater than available data suggest, particularly among developing countries. Globally, agriculture and food production remain one of

11680-506: The area did seem to have an effect, with the El Paso Herald reporting "The cleanliness of the infantry camp and the activity of the city health officers has resulted in Chihuahuita turning over a new leaf. Chihuahuita is clean." However, in 1915, a report of the area wrote, "Probably in no place in the United States could such crude, beastly, primitive conditions be found as exist in Chihuahuita." The El Paso Herlad wrote about how it

11826-653: The area. Improvements to the area, despite being recommended by individuals such as George E. Kessler , were largely ignored by the city. As the Great Depression hit the country, the poor in Chihuahuita were also affected. Housing projects were built by the El Paso Housing Authority in the 1940s. Also in the 1940s and 50s, gangs of Pachucos heavily influenced Chihuahuita. Gangs such as the Canal Kids, Sinners, Las Pompas, La Chihua and

11972-648: The basis of many modern legal systems, funded the construction of the Hagia Sophia and brought the Christian church under state control. From the 7th century onwards, as the Byzantines and neighbouring Sasanid Persians were severely weakened due to the protracted, centuries-lasting and frequent Byzantine–Sasanian wars , the Muslim Arabs began to make inroads into historically Roman territory, taking

12118-563: The boundary between the lower Don and Samara well into the 19th century. The 1745 atlas published by the Russian Academy of Sciences has the boundary follow the Don beyond Kalach as far as Serafimovich before cutting north towards Arkhangelsk , while other 18th- to 19th-century mapmakers such as John Cary followed Strahlenberg's prescription. To the south, the Kuma–Manych Depression was identified c.  1773 by

12264-632: The breakdown of acetylcholine at the neural synapse . Excess acetylcholine can lead to symptoms like muscle cramps or tremors, confusion, dizziness and nausea. Studies show that farm workers in Ethiopia, Kenya, and Zimbabwe have decreased concentrations of plasma acetylcholinesterase, the enzyme responsible for breaking down acetylcholine acting on synapses throughout the nervous system . Other studies in Ethiopia have observed reduced respiratory function among farm workers who spray crops with pesticides. Numerous exposure pathways for farm workers increase

12410-422: The city was neglecting half of its citizens. However, another Herald article urged the city to " annex Chihuahuita," and considered the area a colony of Mexico. The city of El Paso proposed a program of demolishing unsuitable housing, "one block a week," in 1914. General John J. Pershing offered to clean up the area himself, and said he could introduce "modern sanitary methods." The military's presence near

12556-403: The compound is metabolized and eliminated from the body, and provide insights into the timing of exposure. Markers of biological effect provide an estimation of exposure based on cellular activities related to the mechanism of action. For example, many studies investigating exposure to pesticides often involve the quantification of the acetylcholinesterase enzyme at the neural synapse to determine

12702-590: The continent The prevalent definition of Europe as a geographical term has been in use since the mid-19th century. Europe is taken to be bounded by large bodies of water to the north, west and south; Europe's limits to the east and north-east are usually taken to be the Ural Mountains , the Ural River , and the Caspian Sea ; to the south-east, the Caucasus Mountains , the Black Sea , and

12848-573: The continent. Chinese, for example, uses the word Ōuzhōu ( 歐洲 / 欧洲 ), which is an abbreviation of the transliterated name Ōuluóbā zhōu ( 歐羅巴洲 ) ( zhōu means "continent"); a similar Chinese-derived term Ōshū ( 欧州 ) is also sometimes used in Japanese such as in the Japanese name of the European Union, Ōshū Rengō ( 欧州連合 ) , despite the katakana Yōroppa ( ヨーロッパ ) being more commonly used. In some Turkic languages,

12994-424: The continent. Further from the sea, seasonal differences are more noticeable producing more continental climates . European culture consists of a range of national and regional cultures, which form the central roots of the wider Western civilisation , and together commonly reference ancient Greece and ancient Rome , particularly through their Christian successors , as crucial and shared roots. Beginning with

13140-640: The continents as the lands given by Noah to his three sons; Europe was defined as stretching from the Pillars of Hercules at the Strait of Gibraltar , separating it from Northwest Africa , to the Don, separating it from Asia. The convention received by the Middle Ages and surviving into modern usage is that of the Roman era used by Roman-era authors such as Posidonius , Strabo , and Ptolemy , who took

13286-746: The cost side of pesticide use there can be costs to the environment and costs to human health. Pesticides safety education and pesticide applicator regulation are designed to protect the public from pesticide misuse , but do not eliminate all misuse. Reducing the use of pesticides and choosing less toxic pesticides may reduce risks placed on society and the environment from pesticide use. Pesticides may affect health negatively. mimicking hormones causing reproductive problems, and also causing cancer. A 2007 systematic review found that "most studies on non-Hodgkin lymphoma and leukemia showed positive associations with pesticide exposure" and thus concluded that cosmetic use of pesticides should be decreased. There

13432-505: The decline was even steeper, due to the switchover to transgenic Bt corn . Pesticides increase agricultural yields and lower costs. One study found that not using pesticides reduced crop yields by about 10%. Another study, conducted in 1999, found that a ban on pesticides in the United States may result in a rise of food prices , loss of jobs, and an increase in world hunger. There are two levels of benefits for pesticide use, primary and secondary. Primary benefits are direct gains from

13578-640: The development of major commercial routes along the coast of the Mediterranean and Baltic Seas . The growing wealth and independence acquired by some coastal cities gave the Maritime Republics a leading role in the European scene. The Middle Ages on the mainland were dominated by the two upper echelons of the social structure: the nobility and the clergy. Feudalism developed in France in

13724-718: The end of the 18th century, gave rise to radical economic, cultural, and social change in Western Europe and eventually the wider world. Both world wars began and were fought to a great extent in Europe, contributing to a decline in Western European dominance in world affairs by the mid-20th century as the Soviet Union and the United States took prominence and competed over dominance in Europe and globally. The resulting Cold War divided Europe along

13870-502: The environment and human toxicity. DDT has become less effective, as resistance was identified in Africa as early as 1955, and by 1972 nineteen species of mosquito worldwide were resistant to DDT. Total pesticides use in agriculture in 2021 was 3.54 million tonnes of active ingredients (Mt), a 4 percent increase with respect to 2020, an 11 percent increase in a decade, and a doubling since 1990. Pesticides use per area of cropland in 2021

14016-590: The epic poems of Homer ; in drama with Sophocles and Euripides ; in medicine with Hippocrates and Galen ; and in science with Pythagoras , Euclid , and Archimedes . In the course of the 5th century BCE, several of the Greek city states would ultimately check the Achaemenid Persian advance in Europe through the Greco-Persian Wars , considered a pivotal moment in world history, as

14162-409: The exact biological mechanism which the pesticide disrupts. The modes of action are important for resistance management, and are categorized and administered by the insecticide , herbicide , and fungicide resistance action committees. Pesticides may be systemic or non-systemic. A systemic pesticide moves (translocates) inside the plant. Translocation may be upward in the xylem , or downward in

14308-589: The field is often impractical and many methods are not sensitive enough to detect low-level concentrations. Rapid cholinesterase test kits exist to collect blood samples in the field. Conducting large scale assessments of agricultural workers in remote regions of developing countries makes the implementation of these kits a challenge. The cholinesterase assay is a useful clinical tool to assess individual exposure and acute toxicity. Considerable variability in baseline enzyme activity among individuals makes it difficult to compare field measurements of cholinesterase activity to

14454-584: The following two centuries it conquered Greece , Hispania ( Spain and Portugal ), the North African coast, much of the Middle East , Gaul ( France and Belgium ), and Britannia ( England and Wales ). Expanding from their base in central Italy beginning in the third century BCE, the Romans gradually expanded to eventually rule the entire Mediterranean basin and Western Europe by the turn of

14600-608: The general population, and many others that are specific to occupational exposures of agricultural workers. Beyond farm workers, estimating exposure to family members and children presents additional challenges, and may occur through "take-home" exposure from pesticide residues collected on clothing or equipment belonging to parent farm workers and inadvertently brought into the home. Children may also be exposed to pesticides prenatally from mothers who are exposed to pesticides during pregnancy. Characterizing children's exposure resulting from drift of airborne and spray application of pesticides

14746-505: The growth of the pesticide industry. During this period, it became increasingly evident that DDT, which had been sprayed widely in the environment to combat the vector, had accumulated in the food chain . It had become a global pollutant, as summarized in the well-known book Silent Spring .Finally, DDT was banned in the 1970s in several countries, and subsequently all persistent pesticides were banned worldwide, an exception being spraying on interior walls for vector control. Resistance to

14892-651: The height of its power during the High Middle Ages. An East-West Schism in 1054 split the former Roman Empire religiously, with the Eastern Orthodox Church in the Byzantine Empire and the Roman Catholic Church in the former Western Roman Empire. In 1095 Pope Urban II called for a crusade against Muslims occupying Jerusalem and the Holy Land . In Europe itself, the Church organised

15038-509: The idea of water boundaries as the only legitimate divides between Europe and Asia. Four years later, in 1725, Philip Johan von Strahlenberg was the first to depart from the classical Don boundary. He drew a new line along the Volga , following the Volga north until the Samara Bend , along Obshchy Syrt (the drainage divide between the Volga and Ural Rivers ), then north and east along

15184-539: The largest industries. In East Africa, the agricultural industry represents one of the largest sectors of the economy, with nearly 80% of its population relying on agriculture for income. Farmers in these communities rely on pesticide products to maintain high crop yields. Some East Africa governments are shifting to corporate farming , and opportunities for foreign conglomerates to operate commercial farms have led to more accessible research on pesticide use and exposure among workers. In other areas where large proportions of

15330-596: The latter waterway to its source in the Ural Mountains . At this point he proposed that mountain ranges could be included as boundaries between continents as alternatives to nearby waterways. Accordingly, he drew the new boundary north along Ural Mountains rather than the nearby and parallel running Ob and Irtysh rivers. This was endorsed by the Russian Empire and introduced the convention that would eventually become commonly accepted. However, this did not come without criticism. Voltaire , writing in 1760 about Peter

15476-440: The magnitude of the inhibitory effect of organophosphate and carbamate pesticides. Another method of quantifying exposure involves measuring, at the molecular level, the amount of pesticide interacting with the site of action. These methods are more commonly used for occupational exposures where the mechanism of action is better understood, as described by WHO guidelines published in "Biological Monitoring of Chemical Exposure in

15622-412: The method of choice in one third of suicides worldwide, and recommended, among other things, more restrictions on the types of pesticides that are most harmful to humans. A 2014 epidemiological review found associations between autism and exposure to certain pesticides, but noted that the available evidence was insufficient to conclude that the relationship was causal. The World Health Organization and

15768-577: The millennium. The Roman Republic ended in 27 BCE, when Augustus proclaimed the Roman Empire . The two centuries that followed are known as the pax romana , a period of unprecedented peace, prosperity and political stability in most of Europe. The empire continued to expand under emperors such as Antoninus Pius and Marcus Aurelius , who spent time on the Empire's northern border fighting Germanic , Pictish and Scottish tribes. Christianity

15914-710: The northwest ( Asturias ) and largely Basque regions in the Pyrenees . This territory, under the Arabic name Al-Andalus , became part of the expanding Umayyad Caliphate . The unsuccessful second siege of Constantinople (717) weakened the Umayyad dynasty and reduced their prestige. The Umayyads were then defeated by the Frankish leader Charles Martel at the Battle of Poitiers in 732, which ended their northward advance. In

16060-416: The optimized compounds must meet several requirements. In addition to being potent (low application rate), they must show low toxicity to non-target organisms, low environmental impact, and viable manufacturing cost. The cost of developing a pesticide in 2022 was estimated to be 350 million US dollars. It has become more difficult to find new pesticides. More than 100 new active ingredients were introduced in

16206-483: The originally Persian name Frangistan ("land of the Franks ") is used casually in referring to much of Europe, besides official names such as Avrupa or Evropa . Clickable map of Europe, showing one of the most commonly used continental boundaries Key: blue : states which straddle the border between Europe and Asia ; green : countries not geographically in Europe, but closely associated with

16352-412: The parent compound or its metabolites in various types of media: urine, blood, serum. Biomarkers may include a direct measurement of the compound in the body before it's been biotransformed during metabolism. Other suitable biomarkers may include the metabolites of the parent compound after they've been biotransformed during metabolism. Toxicokinetic data can provide more detailed information on how quickly

16498-1144: The partial bans on neonicotinoids . Revised 2023 guidance by registration authorities describes the bee testing that is required for new insecticides to be approved for commercial use. In addition to their main use in agriculture , pesticides have a number of other applications. Pesticides are used to control organisms that are considered to be harmful, or pernicious to their surroundings. For example, they are used to kill mosquitoes that can transmit potentially deadly diseases like West Nile virus , yellow fever , and malaria . They can also kill bees , wasps or ants that can cause allergic reactions. Insecticides can protect animals from illnesses that can be caused by parasites such as fleas . Pesticides can prevent sickness in humans that could be caused by moldy food or diseased produce. Herbicides can be used to clear roadside weeds, trees, and brush. They can also kill invasive weeds that may cause environmental damage. Herbicides are commonly applied in ponds and lakes to control algae and plants such as water grasses that can interfere with activities like swimming and fishing and cause

16644-554: The pesticidal activity in a new compound is found in one enantiomer (the eutomer ), the registration and use of the compound as this single enantiomer is preferred. This reduces the total application rate and avoids the tedious environmental testing required when registering a racemate. However if a viable enantioselective manufacturing route cannot be found, then the racemate is registered and used. Insecticides with systemic activity against sucking pests, which are safe to pollinators , are sought after, particularly in view of

16790-399: The plant extracts contained pyrethrum , nicotine , and rotenone among others. The less toxic of these are still in use in organic farming . In the 1940s the insecticide DDT , and the herbicide 2,4-D , were introduced. These synthetic organic compounds were widely used and were very profitable. They were followed in the 1950s and 1960s by numerous other synthetic pesticides, which led to

16936-444: The poetry devoted to it. An alternative view is that of Robert Beekes , who has argued in favour of a pre-Indo-European origin for the name, explaining that a derivation from eurus would yield a different toponym than Europa. Beekes has located toponyms related to that of Europa in the territory of ancient Greece, and localities such as that of Europos in ancient Macedonia . There have been attempts to connect Eurṓpē to

17082-531: The population rely on subsistence, small-scale farming, estimating pesticide use and exposure is more difficult. Pesticides may exhibit toxic effects on humans and other non-target species, the severity of which depends on the frequency and magnitude of exposure. Toxicity also depends on the rate of absorption, distribution within the body, metabolism, and elimination of compounds from the body. Commonly used pesticides like organophosphates and carbamates act by inhibiting acetylcholinesterase activity, which prevents

17228-752: The poverty and unhealthy conditions because they believed they would be able to save enough money to return to Mexico in improved financial standing. Progressive-era reformers in El Paso looked to Chihuahuita as an area that needed attention. A physician, J.A. Samaniego, appealed to the city on June 16, 1910 to create trash collection in the area. The city council then followed up in July with plans for road paving and expansion of water services. The health department also identified 1,500 houses for demolition in September 1910 and that landowners, rather than tenants should be responsible for housing safety. In 1911, Chihuahuita

17374-480: The realisation of the European Union (EU), which represents today the majority of Europe. The European Union is a supranational political entity that lies between a confederation and a federation and is based on a system of European treaties . The EU originated in Western Europe but has been expanding eastward since the dissolution of the Soviet Union in 1991. A majority of its members have adopted

17520-507: The remote regions of north-western Iberia and the middle Pyrenees the power of the Muslims in the south was scarcely felt. It was here that the foundations of the Christian kingdoms of Asturias , Leon , and Galicia were laid and from where the reconquest of the Iberian Peninsula would start. However, no coordinated attempt would be made to drive the Moors out. The Christian kingdoms were mainly focused on their own internal power struggles. As

17666-421: The risk of pesticide poisoning, including dermal absorption walking through fields and applying products, as well as inhalation exposure. There are multiple approaches to measuring a person's exposure to pesticides, each of which provides an estimate of an individual's internal dose. Two broad approaches include measuring biomarkers and markers of biological effect. The former involves taking direct measurement of

17812-535: The state of the Golden Horde with headquarters in Crimea, which later adopted Islam as a religion, and ruled over modern-day southern and central Russia for more than three centuries. After the collapse of Mongol dominions, the first Romanian states (principalities) emerged in the 14th century: Moldavia and Walachia . Previously, these territories were under the successive control of Pechenegs and Cumans. From

17958-475: The target organisms listed in the table. A structural class is usually associated with a single mode of action , whereas a mode of action may encompass more than one structural class. The pesticidal chemical ( active ingredient ) is mixed ( formulated ) with other components to form the product that is sold, and which is applied in various ways. Pesticides in gas form are fumigants . Pesticides can be classified based upon their mode of action , which indicates

18104-480: The undocumented immigrants there and cause problems for those in the neighborhood. However, a survey conducted by the Border Rights Coalition in 1993 discovered that around 35% of Chihuahuita's residents didn't feel any safer despite the efforts of Border Patrol officers. Data collected between 1994 and 1996 do show a decrease in crime, with a 92% drop in Chihuahuita after Operation Blockade. When

18250-442: The use of pesticides and secondary benefits are effects that are more long-term. Controlling pests and plant disease vectors Controlling human/livestock disease vectors and nuisance organisms Controlling organisms that harm other human activities and structures In 2018 world pesticide sales were estimated to be $ 65 billion, of which 88% was used for agriculture. Generic accounted for 85% of sales in 2018. In one study, it

18396-415: The water to look or smell unpleasant. Uncontrolled pests such as termites and mold can damage structures such as houses. Pesticides are used in grocery stores and food storage facilities to manage rodents and insects that infest food such as grain. Pesticides are used on lawns and golf courses , partly for cosmetic reasons. Integrated pest management , the use of multiple approaches to control pests,

18542-407: The waterways connecting the Black Sea to the Mediterranean Sea . Islands are generally grouped with the nearest continental landmass, hence Iceland is considered to be part of Europe, while the nearby island of Greenland is usually assigned to North America , although politically belonging to Denmark. Nevertheless, there are some exceptions based on sociopolitical and cultural differences. Cyprus

18688-562: The west and the north, transmitting newly acquired skills in producing copper artifacts. In Western Europe the Neolithic period was characterised not by large agricultural settlements but by field monuments, such as causewayed enclosures , burial mounds and megalithic tombs . The Corded Ware cultural horizon flourished at the transition from the Neolithic to the Chalcolithic . During this period giant megalithic monuments, such as

18834-535: The west continued to decline, Roman traditions and the Roman state remained strong in the predominantly Greek-speaking Eastern Roman Empire , also known as the Byzantine Empire . During most of its existence, the Byzantine Empire was the most powerful economic, cultural, and military force in Europe. Emperor Justinian I presided over Constantinople's first golden age: he established a legal code that forms

18980-518: The western shore of the Aegean Sea . As a name for a part of the known world, it is first used in the 6th century BCE by Anaximander and Hecataeus . Anaximander placed the boundary between Asia and Europe along the Phasis River (the modern Rioni River on the territory of Georgia ) in the Caucasus, a convention still followed by Herodotus in the 5th century BCE. Herodotus mentioned that

19126-739: The widespread use of pottery—began around 7000 BCE in Greece and the Balkans , probably influenced by earlier farming practices in Anatolia and the Near East . It spread from the Balkans along the valleys of the Danube and the Rhine ( Linear Pottery culture ), and along the Mediterranean coast ( Cardial culture ). Between 4500 and 3000 BCE, these central European neolithic cultures developed further to

19272-490: The wire-mesh border fence was built in 2008 on the Mexico-United States border , with part of it bordering Chihuahuita, it blocked the view of the green Rio Grande and canal area. Residents say that the fence has stopped illegal immigration in the area. Some residents report that they miss being able to swim in the canal. An exhibit featuring Chihuahuita opened at the El Paso Museum of History in 2014. Chihuahuita

19418-627: The world had been divided by unknown persons into three parts—Europe, Asia, and Libya (Africa)—with the Nile and the Phasis forming their boundaries—though he also states that some considered the River Don , rather than the Phasis, as the boundary between Europe and Asia. Europe's eastern frontier was defined in the 1st century by geographer Strabo at the River Don. The Book of Jubilees described

19564-410: The world. The place name Evros was first used by the ancient Greeks to refer to their northernmost province, which bears the same name today. The principal river there – Evros (today's Maritsa ) – flows through the fertile valleys of Thrace , which itself was also called Europe, before the term meant the continent. In classical Greek mythology , Europa ( Ancient Greek : Εὐρώπη , Eurṓpē )

19710-700: The world. Between the 16th and 20th centuries, European powers colonised at various times the Americas , almost all of Africa and Oceania , and the majority of Asia. The Age of Enlightenment , the French Revolution , and the Napoleonic Wars shaped the continent culturally, politically, and economically from the end of the 17th century until the first half of the 19th century. The Industrial Revolution , which began in Great Britain at

19856-415: The world’s total agricultural land. Pesticides have become more effective. Application rates fell from 1,000–2,500 grams of active ingredient per hectare (g/ha) in the 1950s to 40–100 g/ha in the 2000s. Despite this, amounts used have increased. In high income countries over 20 years between the 1990s and 2010s amounts used increased 20%, while in the low income countries amounts increased 1623%. The aim

20002-422: Was legalised by Constantine I in 313 CE after three centuries of imperial persecution . Constantine also permanently moved the capital of the empire from Rome to the city of Byzantium (modern-day Istanbul ) which was renamed Constantinople in his honour in 330 CE. Christianity became the sole official religion of the empire in 380 CE, and in 391–392 CE the emperor Theodosius outlawed pagan religions. This

20148-478: Was 2.26 kg per hectare (kg/ha), an increase of 4 percent with respect to 2020; use per value of agricultural production was 0.86 kg per thousand international dollar (kg/1000 I$ ) (+2%); and use per person was 0.45 kg per capita (kg/cap) (+3%). Between 1990 and 2021, these indicators increased by 85 percent, 3 percent, and 33 percent, respectively. Brazil was the world's largest user of pesticides in 2021, with 720 kt of pesticides applications for agricultural use, while

20294-461: Was a Phoenician princess. One view is that her name derives from the Ancient Greek elements εὐρύς ( eurús ) 'wide, broad', and ὤψ ( ōps , gen. ὠπός , ōpós ) 'eye, face, countenance', hence their composite Eurṓpē would mean 'wide-gazing' or 'broad of aspect'. Broad has been an epithet of Earth herself in the reconstructed Proto-Indo-European religion and

20440-427: Was a potential "plague spot." The Herald also described how residents were being charged high rates in exchange for substandard conditions. In 1916, the city dealt with Chihuahuita's many health and infrastructure problems by destroying much of the area's housing, displacing residents, many of whom moved back to Ciudad Juarez. A new tax in the form of a $ 5 license for manufacturers and sellers of food and food products

20586-692: Was built at South Chihuahua and Third streets in 1882. An electric power plant was constructed by the El Paso Electric Railway Company at Fourth and Santa Fe streets in 1901. A severe criticism of Chihuahuita at the time included its illegal saloons and red light district . However, the city of El Paso itself had moved all regulated prostitution into Chihuahuita in the late 1800s. Prostitutes were charged an operating fee of $ 5.00 per week. The 1910 Mexican Revolution resulted in numerous Mexicans moving north to Chihuahuita, many as refugees. Residents of Chihuahuita sympathized with

20732-407: Was enacted by the city in 1917. This license forced many producers and food vendors in Chihuahuita to go out of business because it was too expensive to pay. Health issues in the area continued to be noticed through 1922. However, spraying pesticides targeting mosquitoes in the area in the 1930s and increased immunization rates of children in the area helped reduce the number of health issues in

20878-450: Was estimated that for every dollar ($ 1) that is spent on pesticides for crops results in up to four dollars ($ 4) in crops which would otherwise be lost to insects, fungi and weeds. In general, farmers benefit from having an increase in crop yield and from being able to grow a variety of crops throughout the year. Consumers of agricultural products also benefit from being able to afford the vast quantities of produce available year-round. On

21024-619: Was eventually absorbed into Russia several centuries later. The period between the year 1000 and 1250 is known as the High Middle Ages , followed by the Late Middle Ages until c. 1500. During the High Middle Ages the population of Europe experienced significant growth, culminating in the Renaissance of the 12th century . Economic growth, together with the lack of safety on the mainland trading routes, made possible

21170-468: Was known country-wide for having an extremely high mortality rate , twice as high as areas in New York City . City plans in 1912 included standardizing and paving the roads and improving living conditions for residents of the neighborhood. Problems concerning infrastructure and community health in Chihuahuita were compounded by the lack of action on behalf of the city of El Paso, who made plans, but did not always follow through. The El Paso Herald wrote that

21316-495: Was the first crisis that would strike Europe in the late Middle Ages. The period between 1348 and 1420 witnessed the heaviest loss. The population of France was reduced by half. Medieval Britain was afflicted by 95 famines, and France suffered the effects of 75 or more in the same period. Europe was devastated in the mid-14th century by the Black Death , one of the most deadly pandemics in human history which killed an estimated 25 million people in Europe alone—a third of

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