Amgen Inc. (formerly Applied Molecular Genetics Inc. ) is an American multinational biopharmaceutical company headquartered in Thousand Oaks, California . One of the world's largest independent biotechnology companies, As of 2022, Amgen has approximately 24,000 staff in total.
102-628: The name "AMGen" is a portmanteau of the company's original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after incorporation and coincident with its initial public offering ). The company is listed on the Nasdaq Global Select Market under the ticker symbol "AMGN", as well as a component of the Nasdaq-100 , the Dow Jones Industrial Average , and
204-426: A compound , which fully preserves the stems of the original words. The British lecturer Valerie Adams's 1973 Introduction to Modern English Word-Formation explains that "In words such as motel ..., hotel is represented by various shorter substitutes – ‑otel ... – which I shall call splinters. Words containing splinters I shall call blends". Thus, at least one of the parts of a blend, strictly speaking,
306-560: A KRAS G12C mutation and who have received at least one prior systemic therapy; this was the first approved targeted therapy for tumors with any KRAS mutation. Similar approvals for sotorasib in NSCLC followed in January 2022 in Europe and Japan. In September 2022, data from a late-stage study showed the company's cancer pill Lumakras beating out chemotherapy. This was the first approved drug in
408-600: A Phase III trial comparing the compound with ustekinumab and a placebo in treating psoriasis . In the same month, construction was completed on Amgen's next-generation biomanufacturing facility in Singapore. Blincyto ( blinatumomab ) was approved by the FDA in December of that year. Amgen's Thousand Oaks staff in 2022 numbered approximately 5,000 (8.5% of total city employment) and included hundreds of scientists, making Amgen
510-401: A breakthrough in finding and cloning the erythropoietin gene, a protein created in the kidney that stimulates red blood cell production. Lin's team created what would become Epogen ( epoetin alfa ). In 1985, Amgen researcher Larry Souza and his team cloned granulocyte colony-stimulating factor (G-CSF), leading to the development of Neupogen ( filgrastim ). In October 1988, Gordon Binder
612-475: A considerable range in climate because of differences in topography between one part of the county and another. Rainfall is limited in summer and crops have to be irrigated. The average annual temperature is near 60 °F at low elevations near the ocean, in the 50s over most of the northern two-thirds of the county, and less than 45 °F in the Topatopa Mountains . The annual range in temperature
714-535: A form suitable for carrying on horseback; (now esp.) one in the form of a stiff leather case hinged at the back to open into two equal parts". According to The American Heritage Dictionary of the English Language ( AHD ), the etymology of the word is the French porte-manteau , from porter , "to carry", and manteau , "cloak" (from Old French mantel , from Latin mantellum ). According to
816-426: A household in the county was $ 59,666, and the median income for a family was $ 65,285. Males had a median income of $ 45,310, versus $ 32,216 for females. The per capita income for the county was $ 24,600. About 6.4% of families and 9.2% of the population were below the poverty line , including 11.6% of those under age 18 and 6.3% of those aged 65 or over. According to an updated 2005 US Census, median household income
918-427: A kind of bath), the attributive blends of English are mostly head-final and mostly endocentric . As an example of an exocentric attributive blend, Fruitopia may metaphorically take the buyer to a fruity utopia (and not a utopian fruit); however, it is not a utopia but a drink. Coordinate blends (also called associative or portmanteau blends) combine two words having equal status, and have two heads. Thus brunch
1020-561: A manufacturing facility near Dublin, Ireland, in March. Amgen also opened an affiliate in China in 2013. In November 2014 the company announced it was halting all trials of rilotumumab in advanced gastric cancer patients after one of the trials found more deaths in those who took the compound with chemotherapy, than those without. Later in the same week, the company in conjunction with AstraZeneca reported positive results for brodalumab in
1122-545: A pre-historic contact with Polynesians . According to diachronic linguistics , certain words such as tomolo'o (canoe) could be related to Polynesian languages . The dialect of the Chumash language that was spoken in Ventura County was Ventureño . Several place names in the county has originated from Chumash, including Ojai , which means moon, and Simi Valley, which originates from the word Shimiyi and refers to
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#17327833711051224-486: A total blend, each of the words creating the blend is reduced to a mere splinter. Some linguists limit blends to these (perhaps with additional conditions): for example, Ingo Plag considers "proper blends" to be total blends that semantically are coordinate, the remainder being "shortened compounds". Commonly for English blends, the beginning of one word is followed by the end of another: Much less commonly in English,
1326-412: Is frankenword , an autological word exemplifying the phenomenon it describes, blending " Frankenstein " and "word". Ventura County, California Ventura County ( / v ɛ n ˈ t ʊər ə / ) is a county located in the southern part of the U.S. state of California . As of the 2020 census , the population was 843,843. The largest city is Oxnard , and the county seat
1428-477: Is a Japanese blend that has entered the English language. The Vietnamese language also encourages blend words formed from Sino-Vietnamese vocabulary . For example, the term Việt Cộng is derived from the first syllables of "Việt Nam" (Vietnam) and "Cộng sản" (communist). Many corporate brand names , trademarks, and initiatives, as well as names of corporations and organizations themselves, are blends. For example, Wiktionary , one of Misplaced Pages 's sister projects,
1530-496: Is a blend of wiki and dictionary . The word portmanteau was introduced in this sense by Lewis Carroll in the book Through the Looking-Glass (1871), where Humpty Dumpty explains to Alice the coinage of unusual words used in " Jabberwocky ". Slithy means "slimy and lithe" and mimsy means "miserable and flimsy". Humpty Dumpty explains to Alice the practice of combining words in various ways, comparing it to
1632-517: Is between 70 °F and 80 °F on the Coastal Plain and as much as 100 °F in the interior. For July, the average maximum temperature is between 70 °F and 80 °F on the Coastal Plain but exceeds 90 °F in the upper part of the Ventura- and Cuyama River Valleys. For January, the average minimum temperature is near 40 °F on the coast but in the lower 30s and upper 20s in
1734-440: Is both phonological and orthographic, but with no other shortening: The overlap may be both phonological and orthographic, and with some additional shortening to at least one of the ingredients: Such an overlap may be discontinuous: These are also termed imperfect blends. It can occur with three components: The phonological overlap need not also be orthographic: If the phonological but non-orthographic overlap encompasses
1836-526: Is in greenbelts between the cities. Because of this, its private low-key location, its country feel, and its proximity to Los Angeles, the Conejo Valley area has become a very attractive place to live. Like most areas of Ventura County, it once had relatively inexpensive real estate, but prices have risen sharply. For example, real estate in Newbury Park has increased in price by more than 250% in
1938-505: Is known for its steep coastal terrain with little beach access, nearby County Line Beach in the south coast community of Solromar is part of the fabled Malibu coastline. Ventura County has plenty of other surf spots along the coast including the notable surf spot, Rincon Point , on the Santa Barbara County-line. The Channel Islands in Ventura County are Anacapa and San Nicholas Islands . Ventura County has
2040-590: Is lacking". Also on this expedition was Father Junípero Serra , who later founded a mission on this site. On March 31, 1782, the Mission San Buenaventura was founded by Father Serra. It is named after Saint Bonaventure , one of the early intellectual founders of the Franciscan order. The town that grew up around the mission was originally named San Buenaventura (and retains the name officially), it has been known as Ventura since 1891. In
2142-699: Is neither a breakfasty lunch nor a lunchtime breakfast but instead some hybrid of breakfast and lunch; Oxbridge is equally Oxford and Cambridge universities. This too parallels (conventional, non-blend) compounds: an actor–director is equally an actor and a director. Two kinds of coordinate blends are particularly conspicuous: those that combine (near‑) synonyms: and those that combine (near‑) opposites: Blending can also apply to roots rather than words, for instance in Israeli Hebrew : "There are two possible etymological analyses for Israeli Hebrew כספר kaspár 'bank clerk, teller'. The first
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#17327833711052244-664: Is not a complete morpheme , but instead a mere splinter or leftover word fragment. For instance, starfish is a compound, not a blend, of star and fish , as it includes both words in full. However, if it were called a " stish " or a " starsh ", it would be a blend. Furthermore, when blends are formed by shortening established compounds or phrases, they can be considered clipped compounds , such as romcom for romantic comedy . Blends of two or more words may be classified from each of three viewpoints: morphotactic, morphonological, and morphosemantic. Blends may be classified morphotactically into two kinds: total and partial . In
2346-452: Is similar to a contraction . On the one hand, mainstream blends tend to be formed at a particular historical moment followed by a rapid rise in popularity. Contractions, on the other hand, are formed by the gradual drifting together of words over time due to them commonly appearing together in sequence, such as do not naturally becoming don't (phonologically, / d uː n ɒ t / becoming / d oʊ n t / ). A blend also differs from
2448-422: Is small, conserving water and obtaining water from additional sources outside of Ventura County are vital concerns. The climate, though mostly mild and dry, varies because of the variations in topography through for instance differences in elevation and physical geography. The Santa Clara River is the principal waterway. Lake Casitas , an artificial reservoir, is the largest body of water. The highest peaks in
2550-405: Is that it consists of (Hebrew>) Israeli כסף késef 'money' and the ( International /Hebrew>) Israeli agentive suffix ר- -ár . The second is that it is a quasi- portmanteau word which blends כסף késef 'money' and (Hebrew>) Israeli ספר √spr 'count'. Israeli Hebrew כספר kaspár started as a brand name but soon entered the common language. Even if the second analysis is the correct one,
2652-860: Is the city of Ventura . Ventura County comprises the Oxnard–Thousand Oaks–Ventura, CA Metropolitan Statistical Area, which is part of the Greater Los Angeles area (Los Angeles–Long Beach, CA Combined Statistical Area). It is also considered the southernmost county along the California Central Coast . Two of the Channel Islands are part of the county: Anacapa Island , which is the most visited island in Channel Islands National Park , and San Nicolas Island . Ventura County
2754-566: The Chumash Wilderness in the northernmost portion, adjacent to Kern County , as well as the large Sespe Wilderness and portions of both the Dick Smith Wilderness and Matilija Wilderness (both of these protected areas straddle the line with Santa Barbara County). All of the wilderness areas are within the jurisdiction of Los Padres National Forest. The coastal plain was formed by the deposition of sediments from
2856-533: The OED Online , the etymology of the word is the "officer who carries the mantle of a person in a high position (1507 in Middle French), case or bag for carrying clothing (1547), clothes rack (1640)". In modern French, a porte-manteau is a clothes valet , a coat-tree or similar article of furniture for hanging up jackets, hats, umbrellas and the like. An occasional synonym for "portmanteau word"
2958-871: The S&;P 100 and 500 indices. Amgen was established in Thousand Oaks in 1980, as Applied Molecular Genetics. Amgen was backed by a small group of venture capitalists, and its early focus was on recombinant DNA technology and recombinant human insulin . Its initial scientific advisory board consisted of Norman Davidson , Leroy Hood , Arnold Berk , John Carbon , Robert Schimke , Arno Motulsky , Marvin H. Caruthers , and Dave Gibson. In October 1980, Amgen named George Rathmann its first president and chief executive officer. On June 17, 1983, Amgen went public, selling two million common shares and raising nearly $ 40 million. That same year, after more than two years of work, an Amgen research team led by Fu-Kuen Lin had
3060-674: The Santa Clara River and from the streams of the Calleguas-Conejo drainage system. It has a mean elevation of fifty feet (15 m), but at points south of the Santa Clara River, the elevation is as much as 150 feet (46 m), and at points north of the river, as much as 300 feet (91 m). The coastal plain is generally known as the Oxnard Plain with the part that centers on Camarillo lying east of
3162-634: The U.S. 101 corridor and sent population rising in West County cities as well. The largest population growth there has been in Camarillo, Oxnard, and Ventura. Development in the East County and along the US 101 corridor is rare today, because most of these cities, such as Thousand Oaks and Simi Valley, are approaching build-out. Although the area still has plenty of open space and land, almost all of it
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3264-665: The Ventura River is a narrow valley north of Ventura . Ojai Valley is connected to the Ventura River Valley by San Antonio Creek. The small Upper Ojai Valley , east of Ojai Valley and 300 to 500 feet (91 to 152 m) higher, drains to the Ventura River on the west and to Santa Paula Creek on the east. Ojai and Upper Ojai Valleys are surrounded by mountains and are rich agricultural areas. The Ventura River flows south and drains an area of 226 square miles (590 km ). Over South Mountain and Oak Ridge, south of
3366-520: The 1790s, the Spanish Governor of California began granting land concessions to Spanish Californians who were often retiring soldiers. These concessions were known as ranchos and consisted of thousands of acres of land that were used primarily as ranch land for livestock. In Ventura County, Rancho Simi was granted in 1795 and Rancho El Conejo in 1802. Fernando Tico was granted Ojai and part of Ventura by Gov. Alvarado. In 1822, California
3468-914: The Amgen Foundation announced a commitment of up to $ 12.5 million to support COVID-19 relief efforts in March. Amgen's approved drugs or therapeutic biologicals include: In 2019, the company's largest selling products were Enbrel ( etanercept ), a tumor necrosis factor blocker used in the treatment of rheumatoid arthritis and other autoimmune diseases, and Neulasta ( pegfilgrastim ), an immunostimulator used to prevent infections in patients undergoing cancer chemotherapy . As of August 2022, Amgen had 17 clinical programs underway in Phase III, eight in Phase II, and 19 in Phase I. In September 2019, FDA granted fast track designation to sotorasib for
3570-477: The COVID R&;D alliance, announced the first patient enrolled in another trial evaluating Otezla and two other drugs as treatments for COVID-19. Amgen also announced that it would terminate its collaboration with Cytokinetics and transition the development and commercialization rights for omecamtiv mecarbil and AMG 594. Amgen and AstraZeneca announced positive topline results from a Phase 3 trial in which
3672-569: The Church to a secular administrator. The natives who had been working at the mission gradually left to work on the ranchos. By 1839, only 300 Indians were left at the Mission and it slipped into neglect. Several outhouses dating back to the 1800s were discovered in July 2007, at a site that had been cleared to prepare for development. The area proved to be a treasure trove for archaeologists who braved
3774-624: The CodeBreaK 100 clinical study, evaluating sotorasib in 126 patients with KRAS G12C-mutant advanced NSCLC who had failed three or fewer prior lines of anti-cancer therapies (including immunotherapy and/or chemotherapy). Amgen, the Global Coalition for Adaptive Research, and Eisai Co., Ltd. also announced enrollment of the first patient in a study testing multiple interventions for the treatment of patients hospitalized with COVID-19. In November 2020, Amgen, Takeda, and UCB , as part of
3876-636: The Conejo Grade. Geographically East County is the end of the Santa Monica Mountains , in which the Conejo Valley is located, and where there is a considerable increase in elevation. Communities which are considered to be in the East County are Thousand Oaks , Newbury Park , Lake Sherwood , Hidden Valley , Santa Rosa Valley, part of Westlake Village, Oak Park , Moorpark, and Simi Valley. A majority of these communities are in
3978-476: The Conejo Valley. West County, which is everything west of the Conejo Grade, consists of communities such as Camarillo , Oxnard, Somis, Point Mugu, Port Hueneme, Ventura, Ojai, Santa Paula, and Fillmore. West County consists of some of the first developed cities in the county. The largest beach communities are located in West County on the coastline of the Channel Islands Harbor. Starting in
4080-703: The Las Posas-Simi area from the Santa Rosa Valley and Tierra Rejada Valley. The intermountain valley of the Santa Clara River is the most prominent valley in the county and trends east–southwest. The Santa Clara River drains an area of 1,605 square miles (4,160 km ) and flows from its headwaters in Los Angeles to where it empties into the Pacific. Its principal tributaries are Piru Creek , Santa Paula Creek, and Sespe Creek . The valley of
4182-643: The Mission. Fremont and the Battalion continued south to sign the Treaty of Cahuenga with General Andrés Pico . The Treaty of Guadalupe Hidalgo formally transferred California to the United States in 1848. By 1849, a constitution had been adopted for the California territory. The new Legislature met and divided the pending state into 27 counties. At the time, the area that would become Ventura County
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4284-409: The Oxnard–Thousand Oaks–Ventura, CA Metropolitan Statistical Area. The United States Census Bureau ranked the Oxnard–Thousand Oaks–Ventura, CA Metropolitan Statistical Area as the 66th most populous metropolitan statistical area of the United States as of July 1, 2012. The Office of Management and Budget has further designated the Oxnard–Thousand Oaks–Ventura, CA Metropolitan Statistical Area as
4386-622: The Revelon Slough is called Pleasant Valley. Most of the arable land in the county is found on the coastal plain. Small coastal mountains rim Ventura County on its landward side. They range in elevation from 50 feet (15 m) along the coast south of the coastal plain, to about 3,100 feet (940 m) in the Santa Monica Mountains. The Santa Ynez Mountains, the Topatopa Mountains , and the Piru Mountains make up
4488-657: The Santa Clara River, are Las Posas Valley and Simi Valley. Las Posas Valley extends eastward from the Oxnard Plain almost to Simi Valley, which is in the east end of Ventura County. The city of Simi Valley is bounded on the east by the Santa Susana Mountains and on the south by the Simi Hills. To the south, over the Camarillo- and Las Posas Hills, are Santa Rosa- and Tierra Rejada Valleys, which extend from Camarillo eastward for ten miles (16 km). In
4590-592: The Santa Clarita Valley killing as many as 600 people, destroying 1,240 homes and flooding 7,900 acres (32 km ) of land, devastating farm fields and orchards. This was the single largest disaster to strike Ventura County and the second largest, in terms of lives lost, in the state. Ventura County can be separated into two major parts, East County and West County, which are divided by the Conejo Grade . East County consists of all cities east of
4692-449: The annual total is more than thirty-three inches. The drier parts of the county get less than five inches of rain annually, and the higher and wetter parts get more than 60 inches annually. Measureable amounts of rainfall in Ventura County are reported on thirty to thirty-five days annually, and half an inch or more on six to twelve days annually. In the northern parts of Ventura County, snowfall averages five inches or more per year, and along
4794-481: The area that would become Ventura County. Active occupation of California by Spain began in 1769. Gaspar de Portolà led a military expedition by land from San Diego to Monterey , passing through Ventura County in August of that year. A priest with the expedition, Father Juan Crespí , kept a journal of the trip and noted that the area was ideal for a mission to be established and it was a "good site to which nothing
4896-502: The beginning of one word may be followed by the beginning of another: Some linguists do not regard beginning+beginning concatenations as blends, instead calling them complex clippings, clipping compounds or clipped compounds . Unusually in English, the end of one word may be followed by the end of another: A splinter of one word may replace part of another, as in three coined by Lewis Carroll in " Jabberwocky ": They are sometimes termed intercalative blends; these words are among
4998-523: The body longer. This led to the development of Aranesp ( darbepoetin alfa ). In November 1998, Immunex, a future acquisition of Amgen, received approval for Enbrel (etanercept), the first rheumatoid arthritis drug targeting tumor necrosis factor alpha (TNF-alpha). Binder was succeeded as CEO by Kevin W. Sharer in 2000. Robert A. Bradway became Amgen's president and chief executive officer in May 2012, following Sharer's retirement. In March 2011, Amgen acquired
5100-504: The census of 2000, there were 753,197 people, 243,234 households, and 182,911 families living in the county. The population density was 408 inhabitants per square mile (158/km ). There were 251,712 housing units at an average density of 136 per square mile (53/km ). The racial makeup of the county was 69.9% White , 5.4% Asian , 2.0% Black or African American , 0.9% Native American , 0.2% Pacific Islander , 17.7% from other races , and 3.9% from two or more races. About one third (33.4%) of
5202-425: The city remains officially known as San Buenaventura, it is more commonly referred to as Ventura. The rail line to Northern California originally went through Saugus , Fillmore and Santa Paula, providing a boom to those communities along the line. In 1905, Tunnel #26 was completed between Chatsworth and Corriganville near Simi Valley, shortening the rail route. At a length of 7,369 feet (2,246 m), Tunnel #26
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#17327833711055304-526: The company of pursuing profits while putting patients at risk. Larry Husten, a contributor at Forbes.com elaborates on AMGEN's illegal marketing practices in this case, namely that the "government accused Amgen of marketing Aranesp for indications not approved by the FDA and other illegal marketing practices". Amgen engages with the public and private sectors in a variety of settings including to promote research and development , academic funding, event sponsorship, philanthropy , and political lobbying . Amgen
5406-422: The company's flagship manufacturing site. In 1994, Amgen became the fifth company to receive the U.S. Department of Commerce 's National Medal of Technology and Innovation , in recognition of its work developing medicines to improve quality of life for kidney and cancer patients. Also around this time, Amgen researcher Steve Elliott and his team added more sugar molecules to erythropoietin, causing it to remain in
5508-403: The county government is responsible for housing goals in unincorporated areas. Several affordable housing groups that are actively working on building housing for veterans and low income people have long waiting lists. Farmworker housing also has waiting lists though designated units continue to be built. The United States Office of Management and Budget has designated Ventura County as
5610-537: The county include Mount Pinos (8,831 ft; 2,692 m), Frazier Mountain (8,017 ft; 2,444 m), and Reyes Peak (7,525 ft; 2,294 m) in the Transverse Ranges . The uplands are well-timbered with coniferous forests , and receive plentiful snow in the winter. Mount Pinos is sacred to the Chumash Indians. It is known to them as Iwihinmu, and was considered to be the center of
5712-497: The county's total area is made up of national forest. Of the land outside of national forest land, approximately 59 percent is agricultural and 17.5 percent urban. North of Highway 126, the county is mountainous and mostly uninhabited, and contains some of the most unspoiled, rugged and inaccessible wilderness remaining in southern California. Most of this land is in the Los Padres National Forest , and includes
5814-670: The county, including the Burro Flats Painted Cave in Simi Valley. The plank canoe, called a tomol in Chumash , was important to their way of life. Canoe launching points on the mainland for trade with the Chumash of the Channel Islands were located at the mouth of the Ventura River , Mugu Lagoon and Point Hueneme. This has led to speculations among archeologists of whether the Chumash could have had
5916-599: The final syllable ר- -ár apparently facilitated nativization since it was regarded as the Hebrew suffix ר- -år (probably of Persian pedigree), which usually refers to craftsmen and professionals, for instance as in Mendele Mocher Sforim 's coinage סמרטוטר smartutár 'rag-dealer'." Blending may occur with an error in lexical selection , the process by which a speaker uses his semantic knowledge to choose words. Lewis Carroll's explanation, which gave rise to
6018-506: The fire caused over $ 2.176 billion (2018 USD) in damages, including more than $ 204.5 million in suppression costs, becoming the seventh-most destructive wildfire in state history. The agriculture industry suffered at least $ 171 million in losses due to the Thomas Fire. Southern California Edison paid the county over $ 11 million in claims related to damages and costs since its equipment was likely associated with one ignition point of
6120-419: The fire near Santa Paula. According to the U.S. Census Bureau , the county has a total area of 2,208 square miles (5,720 km ), of which 1,843 square miles (4,770 km ) is land and 365 square miles (950 km ) (16.5%) is water. Parts of the county are on the Oxnard Plain which includes the cities of Oxnard , Camarillo , Port Hueneme and much of Ventura . Other cities and communities lie in
6222-488: The first high school opening in 1890. Other towns were being established in the county. A plan for Hueneme (later Port Hueneme) was recorded in 1874, and Santa Paula 's plan was recorded in 1875. Along the banks of the Santa Clara River, the township of New Jerusalem (which would eventually be named El Rio ) was founded in 1875 by the owner of general store named Simon Cohen who became its first postmaster and banker in 1882. The community of Nordhoff (later renamed Ojai )
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#17327833711056324-575: The hills north of Ventura, was producing 90,000 barrels (14,000 m ) of oil a day, with annual production of over 1.5 million barrels. More oil fields came online in the 1920s and 1930s, with the Rincon field , the second largest, in 1927, and the adjacent San Miguelito in 1931. In the early hours of the morning of March 12–13, 1928, the St. Francis Dam collapsed, sending nearly 12,500 million U.S. gallons (47 gigaliters) of water rushing through
6426-677: The hills south of Santa Rosa Valley is the broad Conejo Valley. Santa Rosa Valley, Conejo Valley, Simi Valley, and Tierra Rejada Valley are drained by Calleguas Creek and its principal tributary, Conejo Creek. These creeks originate in the Santa Susana and Santa Monica Mountains . The county's diverse 43-mile (69 km) coastline features a variety of terrain. There are many State beaches: Emma Wood , San Buenaventura , McGrath , and Mandalay State Beach . Other beaches include Channel Islands Beach , Solimar Beach , Oxnard Beach Park , and Silver Strand Beach . While Point Mugu State Park
6528-403: The ingredients is the head and the other is attributive. A porta-light is a portable light, not a 'light-emitting' or light portability; light is the head. A snobject is a snobbery-satisfying object and not an objective or other kind of snob; object is the head. As is also true for (conventional, non-blend) attributive compounds (among which bathroom , for example, is a kind of room, not
6630-538: The intermountain valleys of the Transverse Range. The Santa Clara River Valley is the most prominent valley, while other valleys include Conejo Valley , Simi Valley , Santa Rosa Valley , Tierra Rejada Valley and Las Posas Valley. Other parts of the county are on small coastal mountains, such as the Santa Ynez Mountains , Simi Hills , Santa Monica Mountains and the Piru Mountains. Most of
6732-439: The investigational medicine tezepelumab demonstrated a statistically significant reduction in exacerbations in patients with severe asthma. In December 2020, the FDA granted breakthrough therapy designation to sotorasib for advanced or metastatic non-small cell lung cancer patients with KRAS G12C mutation. In May 2021, sotorasib received accelerated approval from FDA for treatment of adult patients with NSCLC whose tumors have
6834-495: The largest employer in Ventura County . In October 2017, the Amgen Foundation pledged $ 3 million to Khan Academy to support the development of free online biology lessons. In July 2020, Amgen granted an additional $ 3 million Khan Academy to support educational equity and science learning. In January 2020, the Amgen Foundation and Harvard University debuted LabXchange, a free online science education platform. Amgen and
6936-556: The last 10 years. The Thomas Fire was a massive wildfire that affected Ventura and Santa Barbara Counties, and one of multiple wildfires that ignited in Southern California in December 2017. It burned approximately 281,893 acres (440 sq mi; 114,078 ha), becoming the largest wildfire in modern California history , before it was fully contained on January 12, 2018. The Thomas Fire destroyed at least 1,063 structures, while damaging 280 others; and
7038-617: The lingering smell in the dirt to uncover artifacts that showed heavy utilization by mission inhabitants, Indians, early settlers and Spanish and Mexican soldiers. The Mexican–American War began in 1846 but its effect was not felt in Ventura County until 1847. In January of that year, Captain John C. Frémont led the California Battalion into San Buenaventura to find that the Europeans had fled, leaving only Native Americans in
7140-512: The mid-20th century, there was a large growth in population in the East County, moving from the San Fernando Valley in Los Angeles and out into the Conejo and Simi Valleys. Part of the Conejo Valley is situated in Los Angeles County . This part consists of Calabasas , Hidden Hills , Agoura Hills , Agoura , and Westlake Village . The other half of the Conejo Valley, which belongs to Ventura County, consists of Lake Sherwood , Hidden Valley , Oak Park , Thousand Oaks , and Newbury Park , which
7242-403: The mission. The number of cattle owned by the mission dropped from first to fifteenth ranking in the California Missions. The missions were secularized by the Mexican government in 1834 . The Mexican governors began granting land rights to Mexican Californians, often retiring soldiers. By 1846, there were 19 rancho grants in Ventura County. In 1836, Mission San Buenaventura was transferred from
7344-495: The morphemes or phonemes stay in the same position within the syllable. Some languages, like Japanese , encourage the shortening and merging of borrowed foreign words (as in gairaigo ), because they are long or difficult to pronounce in the target language. For example, karaoke , a combination of the Japanese word kara (meaning empty ) and the clipped form oke of the English loanword "orchestra" (J. ōkesutora , オーケストラ ),
7446-689: The northern border and Mount Pinos, more than twenty inches. Automobile emissions account for most of the air pollution . Other sources include chemical plants , gasoline stations , paint and cleaning products . Rivers in Ventura County include: The 2010 United States Census reported that Ventura County had a population of 823,318. The racial makeup of Ventura County was 565,804 (68.7%) White , 15,163 (1.8%) African American , 8,068 (1.0%) Native American , 55,446 (6.7%) Asian , 1,643 (0.2%) Pacific Islander , 140,253 (17.0%) from other races , and 36,941 (4.5%) from two or more races. Hispanic or Latino of any race were 331,567 persons (40.3%). As of
7548-596: The northern boundary of the coastal plain, the Santa Susana Mountains are alongside the eastern boundary of the county, and the Simi Hills and the Santa Monica Mountains are along the southern border with Los Angeles County . South Mountain and Oak Ridge are low and long mountains that separate Santa Clara Valley from the Las Posas Valley and Simi Valley . The Camarillo Hills and the Las Posas Hills extend from Camarillo to Simi Valley and separate
7650-481: The northern parts of Ventura County. No temperature data are available for the highest point in the county, Mount Pinos . The length of the growing season ranges more than 300 days near the coast to less than 175 days in the coldest part in northern Ventura County. In both the northern and southern ends of the county, the annual precipitation totals between ten and fifteen inches. In the Topatopa Mountains,
7752-495: The original "portmanteaus" for which this meaning of the word was created. In a partial blend, one entire word is concatenated with a splinter from another. Some linguists do not recognize these as blends. An entire word may be followed by a splinter: A splinter may be followed by an entire word: An entire word may replace part of another: These have also been called sandwich words, and classed among intercalative blends. (When two words are combined in their entirety,
7854-406: The petroleum products under Ventura County but none were financially successful, and the oil speculators eventually changed from oil to land development. In 1913, oil exploration began in earnest, with Ralph Lloyd obtaining the financial support of veteran oil man Joseph B. Dabney. Their first well, named "Lloyd No. 1", was started on January 20, 1914. The well struck oil at 2,558 feet (780 m) but
7956-537: The population is Hispanic or Latino of any race. 9.8% were of German, 7.7% English and 7.1% Irish ancestry according to Census 2000 . 67.1% spoke English, 26.2% Spanish and 1.5% Tagalog as their first language. There were 243,234 households, of which 39.7% had children under the age of 18 living with them, 59.5% were married couples living together, 10.9% had a female householder with no husband present, and 24.8% were non-families. 18.9% of all households were made up of individuals, and 7.4% had someone living alone who
8058-613: The population of Ventura County lives in the southern portion of the county. The major population centers are the Oxnard Plain and the Simi and Conejo Valleys. In local media, the county is usually split between the eastern portion, generally associated with the San Fernando Valley , and the western portion, often referred to as “Oxnard-Ventura". To the east is Los Angeles County . Because the total amount of precipitation
8160-453: The result is considered a compound word rather than a blend. For example, bagpipe is a compound, not a blend, of bag and pipe. ) Morphologically, blends fall into two kinds: overlapping and non-overlapping . Overlapping blends are those for which the ingredients' consonants, vowels or even syllables overlap to some extent. The overlap can be of different kinds. These are also called haplologic blends. There may be an overlap that
8262-654: The set of treatments that target KRAS, among the most common generic mutations found in cancers but one where researchers have struggled for years to design drugs to treat. The drug was approved in 2021 with a list price of $ 17,900 per month. Amgen reported Total CO2e emissions (Direct + Indirect) for the twelve months ending 31 December 2020 at 243 Kt (-6 /-2.4% y-o-y) and aims to reach net zero emissions by 2027. The Los Angeles Times reported on December 18, 2012, that Amgen pleaded guilty and agreed to pay $ 150 million in criminal penalty and $ 612 million to resolve 11 related whistleblower complaints. Federal prosecutors accused
8364-413: The stringy, thread-like clouds that typify the region. Others include Point Mugu from the word Muwu (meaning "beach"), Saticoy from the word Sa'aqtiko'y (meaning "sheltered for the wind"), and Sespe Creek from the word S'eqp'e (meaning "kneecap"). In October 1542, the expedition led by Juan Rodríguez Cabrillo anchored in an inlet near Point Mugu ; its members were the first Europeans to arrive in
8466-484: The then-common type of luggage , which opens into two equal parts: You see it's like a portmanteau—there are two meanings packed up into one word. In his introduction to his 1876 poem The Hunting of the Snark , Carroll again uses portmanteau when discussing lexical selection: Humpty Dumpty's theory, of two meanings packed into one word like a portmanteau, seems to me the right explanation for all. For instance, take
8568-471: The town of San Buenaventura was incorporated, becoming the first officially recognized town in what would become Ventura County. On January 1, 1873, Ventura County was officially split from Santa Barbara County, bringing a flurry of change. That same year, a courthouse and wharf were built in San Buenaventura. A bank was opened and the first public library was created. The school system grew, with
8670-407: The train stop. That community, now bearing the name of the factory shortened to the one word train stop Oxnard, has become the largest city in Ventura County. Oil has been known in Ventura County since before the arrival of the Europeans, as the native Chumash people used tar from natural seeps as a sealant and waterproofing for baskets and canoes. In the 1860s, several attempts were made to harvest
8772-621: The treatment of metastatic non-small-cell lung carcinoma (NSCLC) with the KRAS G12C mutation. In August 2020, Amgen, Takeda , and AbbVie , as part of a COVID-19 research and development (R&D) alliance, announced the first patients enrolled in the I-SPY COVID clinical trial. The trial evaluated the efficacy of Otezla and two other medicines in severely ill, hospitalized COVID-19 patients who required high-flow oxygen. In October 2020, Amgen announced positive topline Phase 2 results from
8874-462: The two words "fuming" and "furious". Make up your mind that you will say both words, but leave it unsettled which you will say first … if you have the rarest of gifts, a perfectly balanced mind, you will say "frumious". In then-contemporary English, a portmanteau was a suitcase that opened into two equal sections. According to the OED Online , a portmanteau is a "case or bag for carrying clothing and other belongings when travelling; (originally) one of
8976-538: The universe; being the highest peak in the vicinity, it has unimpeded views in three directions. The USDA Economic Research Service rated Ventura County the most desirable county to live in the 48 contiguous states, using six metrics of climate ("mild, sunny winters, temperate summers, low humidity"), topographic variation, and access to water, "that reflect environmental qualities most people prefer." There are 555,953 acres (224,986 ha) outside of national forest land in Ventura County, which means that 53 percent of
9078-406: The use of 'portmanteau' for such combinations, was: Humpty Dumpty's theory, of two meanings packed into one word like a portmanteau, seems to me the right explanation for all. For instance, take the two words "fuming" and "furious." Make up your mind that you will say both words ... you will say "frumious." The errors are based on similarity of meanings, rather than phonological similarities, and
9180-404: The way for development westward. The communities that have seen the most substantial development are Calabasas, Hidden Hills, Agoura Hills, Westlake Village, Thousand Oaks, and Newbury Park. The neighboring East County area of Simi Valley saw its already considerable population of nearly 60,000 inhabitants in 1970 grow to over 100,000 over the following two decades. Development moved farther down
9282-542: The whole of the shorter ingredient, as in then the effect depends on orthography alone. (They are also called orthographic blends. ) An orthographic overlap need not also be phonological: For some linguists, an overlap is a condition for a blend. Non-overlapping blends (also called substitution blends) have no overlap, whether phonological or orthographic: Morphosemantically, blends fall into two kinds: attributive and coordinate . Attributive blends (also called syntactic or telescope blends) are those in which one of
9384-591: Was $ 66,859, while the mean was $ 85,032. Per capita income was up to $ 29,634, making it the 6th wealthiest county in California. Ventura County typically has limited housing inventory, making it a consistently expensive location in Southern California, where it is usually the third-most-expensive county behind Orange and Los Angeles counties. As of March 2018 , the county was not on track to meet its state-mandated housing goals. Individual cities are responsible for meeting their assigned housing goals, while
9486-448: Was 65 years of age or older. The average household size was 3.04 and the average family size was 3.46. In the county, the population was spread out, with 28.4% under the age of 18, 9.0% from 18 to 24, 30.7% from 25 to 44, 21.7% from 45 to 64, and 10.2% who were 65 or older. The median age was 34 years. For every 100 females, there were 99.7 males. For every 100 females age 18 and over, there were 97.5 males. The median income for
9588-587: Was destroyed when it went wild. Other wells met a similar fate, until 1916, when a deal was struck with the Shell Oil Company . 1916 was the year that the large South Mountain Oil Field was discovered; other deals followed with General Petroleum in 1917 and Associated Oil Company in 1920. At its peak, the largest oil field in the county, the Ventura Avenue oilfield , discovered in 1919 in
9690-480: Was formerly an unincorporated area that is now the most westerly part of Thousand Oaks. Many working-class people migrated to this area during the 1960s and 1970s out of East and Central Los Angeles . As a result, there was a large growth in population into the Conejo Valley and into Ventura County through the U.S. Route 101 corridor. Making the U.S. 101 a full freeway in the 1960s, and the expansions that followed, helped make commuting to Los Angeles easier and opened
9792-562: Was historically inhabited by the Chumash people , who also settled much of Santa Barbara and San Luis Obispo Counties, with their presence dating back 10,000–12,000 years. The Chumash were hunter-gatherers , fishermen, and also traders with the Mojave , Yokuts , and Tongva Indians. The Chumash are also known for their rock paintings and for their great basketry. Chumash Indian Museum in Thousand Oaks has several reconstructed Chumash houses ('apa) and there are several Chumash pictographs in
9894-500: Was named CEO, succeeding George Rathmann. The following year, in 1989, Amgen received approval for the first recombinant human erythropoetin product, Epogen ( epoetin alfa ). In February 1991, Amgen received FDA approval for Neupogen for the prevention of infections in patients whose immune systems are suppressed due to cancer chemotherapy. Amgen opened a new manufacturing facility in Puerto Rico , in March 1993, which later became
9996-624: Was notified of Mexico's independence from Spain and the Governor of California , the Junta, the military in Monterey and the priests and neophytes at Mission San Buenaventura swore allegiance to Mexico on April 11, 1822. California land that had been vested in the King of Spain was now owned by the nation of Mexico. By the 1830s, Mission San Buenaventura was in a decline with fewer neophytes joining
10098-527: Was ranked 151 on the Fortune 500 list of the largest United States corporations by revenue in 2024. Portmanteau In linguistics , a blend —also known as a blend word , lexical blend , or portmanteau —is a word formed by combining the meanings, and parts of the sounds, of two or more words together. English examples include smog , coined by blending smoke and fog , as well as motel , from motor ( motorist ) and hotel . A blend
10200-454: Was started in 1874. Bardsdale , Fillmore , Piru , and Montalvo were established in 1887. 1892 saw Simi (later Simi Valley), Somis , Saticoy , and Moorpark . Oxnard was a latecomer, not being established until 1898. The Southern Pacific Railroad laid tracks through San Buenaventura in 1887. For convenience in printing their timetables, Southern Pacific shortened San Buenaventura to Ventura. The Post Office soon followed suit. While
10302-507: Was the longest tunnel ever constructed in its day. This tunnel joined to the railroad spur coming the other direction from Montalvo through Camarillo, Moorpark and Simi Valley, making the contemporary main line used today. One stop along the way, at a 90-degree turn, was at a sugar beet processing factory. The factory bore the name of its absentee owners, the Oxnard Brothers. A small community of farm and factory workers grew near
10404-416: Was the southern part of Santa Barbara County . The 1860s brought many changes to the area. A drought caused many of the ranchos to experience financial difficulties and most were divided, sub-divided and sold. Large sections of land were bought by eastern capitalists based on favorable reports of petroleum deposits. A United States Post Office was opened at Mission San Buenaventura in 1861. On April 1, 1866,
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