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111-522: The word admiral in Middle English comes from Anglo-French amiral , "commander", from Medieval Latin admiralis , admirallus . These evolved from the Arabic amīral ( أمير الـ ) – amīr ( أمير ) [ʔmjr] ( listen ), " king , prince , chief, leader, nobleman , lord , a governor , commander , or person who rules over a number of people" and al ( الـ ),

222-547: A change of command ceremony aboard aircraft carrier USS Enterprise (CVN 65) , while docked at Khalifa Bin Salman Port, Bahrain , U.S. Marine Corps Gen . James Mattis , Commander, U.S. Central Command , introduced Vice Admiral Mark I. Fox as "Admiral Fox, the prince of the sea, emir of the sea – to translate 'admiral' from the Arabic to English;" On 04 Feb 2021, in an announcement of his coronavirus -related death,

333-494: A strain of coronavirus known as "severe acute respiratory syndrome coronavirus 2" ( SARS-CoV-2 ). COVID-19 is mainly transmitted when people breathe in air contaminated by droplets / aerosols and small airborne particles containing the virus. Infected people exhale those particles as they breathe, talk, cough, sneeze, or sing. Transmission is more likely the closer people are. However, infection can occur over longer distances, particularly indoors. The transmission of

444-419: A certain critical size, generally thought to be <100μm diameter, evaporate faster than they settle; due to that fact, they form respiratory aerosol particles that remain airborne for a long period of time over extensive distances. Infectivity can begin four to five days before the onset of symptoms. Infected people can spread the disease even if they are pre-symptomatic or asymptomatic . Most commonly,

555-738: A demonstrative ( þis , þat ), after a possessive pronoun (e.g., hir , our ), or with a name or in a form of address. This derives from the Old English "weak" declension of adjectives. This inflexion continued to be used in writing even after final -e had ceased to be pronounced. In earlier texts, multisyllable adjectives also receive a final -e in these situations, but this occurs less regularly in later Middle English texts. Otherwise, adjectives have no ending and adjectives already ending in -e etymologically receive no ending as well. Earlier texts sometimes inflect adjectives for case as well. Layamon's Brut inflects adjectives for

666-815: A dialect of Old French , now known as Old Norman , which developed in England into Anglo-Norman . The use of Norman as the preferred language of literature and polite discourse fundamentally altered the role of Old English in education and administration, even though many Normans of this period were illiterate and depended on the clergy for written communication and record-keeping. A significant number of Norman words were borrowed into English and used alongside native Germanic words with similar meanings. Examples of Norman/Germanic pairs in Modern English include pig and pork , calf and veal , wood and forest , and freedom and liberty . The role of Anglo-Norman as

777-422: A higher risk of developing severe symptoms. Some complications result in death. Some people continue to experience a range of effects ( long COVID ) for months or years after infection, and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease. COVID‑19 transmission occurs when infectious particles are breathed in or come into contact with

888-502: A largely Anglo-Saxon vocabulary (with many Norse borrowings in the northern parts of the country) but a greatly simplified inflectional system. The grammatical relations that were expressed in Old English by the dative and instrumental cases were replaced in Early Middle English with prepositional constructions. The Old English genitive - es survives in the -'s of the modern English possessive , but most of

999-494: A lengthened – and later also modified – pronunciation of a preceding vowel. For example, in name , originally pronounced as two syllables, the /a/ in the first syllable (originally an open syllable) lengthened, the final weak vowel was later dropped, and the remaining long vowel was modified in the Great Vowel Shift (for these sound changes, see Phonology , above). The final ⟨e⟩ , now silent, thus became

1110-495: A lesser extent), and, therefore, it cannot be attributed simply to the influence of French-speaking sections of the population: English did, after all, remain the vernacular . It is also argued that Norse immigrants to England had a great impact on the loss of inflectional endings in Middle English. One argument is that, although Norse and English speakers were somewhat comprehensible to each other due to similar morphology,

1221-491: A more analytic language with a stricter word order. Both Old English and Old Norse were synthetic languages with complicated inflections. Communication between Vikings in the Danelaw and their Anglo-Saxon neighbours resulted in the erosion of inflection in both languages. Old Norse may have had a more profound impact on Middle and Modern English development than any other language. The effect of Old Norse on Old English

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1332-529: A process called apophony ), as in Modern English. With the discontinuation of the Late West Saxon standard used for the writing of Old English in the period prior to the Norman Conquest, Middle English came to be written in a wide variety of scribal forms, reflecting different regional dialects and orthographic conventions. Later in the Middle English period, however, and particularly with

1443-399: A range of effects, such as fatigue , for months, even after recovery. This is the result of a condition called long COVID , which can be described as a range of persistent symptoms that continue for weeks or months at a time. Long-term damage to organs has also been observed after the onset of COVID-19. Multi-year studies are underway to further investigate the potential long-term effects of

1554-571: A standard based on the London dialects (Chancery Standard) had become established. This largely formed the basis for Modern English spelling, although pronunciation has changed considerably since that time. Middle English was succeeded in England by Early Modern English , which lasted until about 1650. Scots developed concurrently from a variant of the Northumbrian dialect (prevalent in northern England and spoken in southeast Scotland ). During

1665-744: Is a novel severe acute respiratory syndrome coronavirus. It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan. All structural features of the novel SARS-CoV-2 virus particle occur in related coronaviruses in nature, particularly in Rhinolophus sinicus (Chinese horseshoe bats). Outside the human body, the virus is destroyed by household soap which bursts its protective bubble . Hospital disinfectants, alcohols, heat, povidone-iodine , and ultraviolet -C (UV-C) irradiation are also effective disinfection methods for surfaces. SARS-CoV-2

1776-662: Is a king in the Arabian language.' Amrayl is used by Robert of Gloucester, in the sense of a prince, or governour." The quote from John Minsheu 's Dictionarie in Spanish and English (1599), given in Johnson's Dictionary, has been confirmed as being accurate. Additionally, the definition of Amīr (أمير), as given in Edward William Lane 's Arabic-English Lexicon , concurs, in part, with Minsheu's definition, stating that

1887-571: Is associated with COVID-19 and is reported in as many as 88% of symptomatic cases. Published data on the neuropathological changes related with COVID-19 have been limited and contentious, with neuropathological descriptions ranging from moderate to severe hemorrhagic and hypoxia phenotypes , thrombotic consequences, changes in acute disseminated encephalomyelitis (ADEM-type), encephalitis and meningitis . Many COVID-19 patients with co-morbidities have hypoxia and have been in intensive care for varying lengths of time, confounding interpretation of

1998-433: Is available, guidelines and recommendations for hypertensive patients remain. The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to

2109-402: Is because pregnant women with COVID‑19 appear to be more likely to develop respiratory and obstetric complications that can lead to miscarriage , premature delivery and intrauterine growth restriction . Fungal infections such as aspergillosis , candidiasis , cryptococcosis and mucormycosis have been recorded in patients recovering from COVID‑19. COVID‑19 is caused by infection with

2220-522: Is closely related to the original SARS-CoV . It is thought to have an animal ( zoonotic ) origin. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus , in subgenus Sarbecovirus (lineage B) together with two bat-derived strains. It is 96% identical at the whole genome level to other bat coronavirus samples (BatCov RaTG13 ). The structural proteins of SARS-CoV-2 include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and

2331-433: Is now rare and used only in oxen and as part of a double plural , in children and brethren . Some dialects still have forms such as eyen (for eyes ), shoon (for shoes ), hosen (for hose(s) ), kine (for cows ), and been (for bees ). Grammatical gender survived to a limited extent in early Middle English before being replaced by natural gender in the course of the Middle English period. Grammatical gender

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2442-595: Is the cause of the bud release and the formation of the viral envelope. The N and E protein are accessory proteins that interfere with the host's immune response. Human angiotensin converting enzyme 2 (hACE2) is the host factor that SARS-CoV-2 virus targets causing COVID‑19. Theoretically, the usage of angiotensin receptor blockers (ARB) and ACE inhibitors upregulating ACE2 expression might increase morbidity with COVID‑19, though animal data suggest some potential protective effect of ARB; however no clinical studies have proven susceptibility or outcomes. Until further data

2553-469: Is the viral component that attaches to the host receptor via the ACE2 receptors. It includes two subunits: S1 and S2. Studies have shown that S1 domain induced IgG and IgA antibody levels at a much higher capacity. It is the focus spike proteins expression that are involved in many effective COVID‑19 vaccines. The M protein is the viral protein responsible for the transmembrane transport of nutrients. It

2664-885: The Alpha variant (B.1.1.7, formerly called the UK variant), first found in London and Kent, the Beta variant (B.1.351, formerly called the South Africa variant), the Gamma variant (P.1, formerly called the Brazil variant), the Delta variant (B.1.617.2, formerly called the India variant), and the Omicron variant (B.1.1.529), which had spread to 57 countries as of 7 December. On December 19, 2023,

2775-615: The Arabic definite article meaning "the." In Arabic, admiral is also represented as Amīr al-Baḥr ( أمير البحر ), where al-Baḥr (البحر) means the sea . The 1818 edition of Samuel Johnson 's A Dictionary of the English Language , edited and revised by the Rev. Henry John Todd , states that the term "has been traced to the Arab. emir or amir, lord or commander, and the Gr . ἄλιος ,

2886-755: The COVID-19 pandemic . The symptoms of COVID‑19 are variable but often include fever, fatigue, cough, breathing difficulties , loss of smell , and loss of taste . Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms . Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging), and 5% develop critical symptoms ( respiratory failure , shock , or multiorgan dysfunction ). Older people are at

2997-616: The Early Modern English and Modern English eras. Middle English generally did not have silent letters . For example, knight was pronounced [ˈkniçt] (with both the ⟨k⟩ and the ⟨gh⟩ pronounced, the latter sounding as the ⟨ch⟩ in German Knecht ). The major exception was the silent ⟨e⟩ – originally pronounced but lost in normal speech by Chaucer's time. This letter, however, came to indicate

3108-594: The Norman Conquest , had normally been written in French. Like Chaucer's work, this new standard was based on the East Midlands-influenced speech of London. Clerks using this standard were usually familiar with French and Latin , influencing the forms they chose. The Chancery Standard, which was adopted slowly, was used in England by bureaucrats for most official purposes, excluding those of

3219-777: The Northern England (corresponding to the Scandinavian Kingdom of Jórvík ), the East Midlands and the East of England , words in the spoken language emerged in the 10th and 11th centuries near the transition from Old to Middle English. Influence on the written languages only appeared from the beginning of the 13th century, this delay in Scandinavian lexical influence in English has been attributed to

3330-588: The Spanish flu , Middle East respiratory syndrome , and Zika virus . In January 2020, the World Health Organization (WHO) recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 guidance and international guidelines against using geographical locations or groups of people in disease and virus names to prevent social stigma . The official names COVID‑19 and SARS-CoV-2 were issued by

3441-482: The small intestine . The virus can cause acute myocardial injury and chronic damage to the cardiovascular system . An acute cardiac injury was found in 12% of infected people admitted to the hospital in Wuhan, China, and is more frequent in severe disease. Rates of cardiovascular symptoms are high, owing to the systemic inflammatory response and immune system disorders during disease progression, but acute myocardial injuries may also be related to ACE2 receptors in

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3552-710: The spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat SARS-CoV, maintains around 98% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only around 38% with the M protein of MERS-CoV . The many thousands of SARS-CoV-2 variants are grouped into either clades or lineages . The WHO, in collaboration with partners, expert networks, national authorities, institutions and researchers, have established nomenclature systems for naming and tracking SARS-CoV-2 genetic lineages by GISAID , Nextstrain and Pango . The expert group convened by

3663-603: The "d" and endured a series of different endings and spellings leading to the English spelling admyrall in the 14th century and to admiral by the 16th century. It is important to note that the etymology of a word does not suggest the antiquity of the word as it may have appeared in other languages with entirely different pronunciations. The Greek ναύαρχος, for instance, which is pronounced "naúarkhēs," existed from very ancient times in Greece. While ναύαρχος may be defined as "admiral" as used by Plutarch in his Parallel Lives ,

3774-645: The 12th century, incorporating a unique phonetic spelling system; and the Ancrene Wisse and the Katherine Group , religious texts written for anchoresses , apparently in the West Midlands in the early 13th century. The language found in the last two works is sometimes called the AB language . Additional literary sources of the 12th and 13th centuries include Layamon's Brut and The Owl and

3885-422: The 13th century and was replaced by thorn. Thorn mostly fell out of use during the 14th century and was replaced by ⟨th⟩ . Anachronistic usage of the scribal abbreviation [REDACTED] ( þe , "the") has led to the modern mispronunciation of thorn as ⟨ y ⟩ in this context; see ye olde . Wynn, which represented the phoneme /w/ , was replaced by ⟨ w ⟩ during

3996-409: The 13th century. Due to its similarity to the letter ⟨p⟩ , it is mostly represented by ⟨w⟩ in modern editions of Old and Middle English texts even when the manuscript has wynn. Under Norman influence, the continental Carolingian minuscule replaced the insular script that had been used for Old English. However, because of the significant difference in appearance between

4107-527: The 14th century, even after the loss of the majority of the continental possessions of the English monarchy . In the aftermath of the Black Death of the 14th century, there was significant migration into London , of people to the counties of the southeast of England and from the east and central Midlands of England, and a new prestige London dialect began to develop as a result of this clash of

4218-663: The 1540s after the printing and wide distribution of the English Bible and Prayer Book , which made the new standard of English publicly recognizable and lasted until about 1650. The main changes between the Old English sound system and that of Middle English include: The combination of the last three processes listed above led to the spelling conventions associated with silent ⟨e⟩ and doubled consonants (see under Orthography , below). Middle English retains only two distinct noun-ending patterns from

4329-622: The Arabic Amīr (أمير), the literal meaning of the phrase Amīr al-Baḥr (أمير البحر) is "Prince of the Sea." This position, versus "commander of the sea," is demonstrated by legal practices prevailing in the Ottoman Empire , whereas it was only possible for Phanariots to qualify for attaining four princely positions, those being grand dragoman , dragoman of the fleet , and the voivodees of Moldavia and Wallachia . Those Phanariots who attained

4440-513: The Arabic news website Saudi 24 News referred to Admiral Edmond Chagoury by the title "Prince of the Sea." One alternate etymology proposes that the term admiral evolved, instead, from the title of Amīr al-Umarā ʾ (أمير الأمراء). Under the reign of the Buyid dynasty (934 to 1062) of Iraq and Iran , the title of Amīr al-Umarāʾ, which means prince of princes, came to denote the heir-apparent , or crown prince . This alternate etymology states that

4551-548: The B.1 lineage. Several notable variants of SARS-CoV-2 emerged throughout 2020. Cluster 5 emerged among minks and mink farmers in Denmark . After strict quarantines and the slaughter of all the country's mink , the cluster was assessed to no longer be circulating among humans in Denmark as of 1 February 2021. As of December 2021 , there are five dominant variants of SARS-CoV-2 spreading among global populations:

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4662-542: The CNS, possibly within an infected white blood cell. Research conducted when Alpha was the dominant variant has suggested COVID-19 may cause brain damage. Later research showed that all variants studied (including Omicron) killed brain cells, but the exact cells killed varied by variant. It is unknown if such damage is temporary or permanent. Observed individuals infected with COVID-19 (most with mild cases) experienced an additional 0.2% to 2% of brain tissue lost in regions of

4773-562: The COVID-19 infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: a respiratory symptom cluster with cough, sputum , shortness of breath , and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; and a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhea. In people without prior ear, nose, or throat disorders, loss of taste combined with loss of smell

4884-572: The Church and legalities, which used Latin and Law French respectively. The Chancery Standard's influence on later forms of written English is disputed, but it did undoubtedly provide the core around which Early Modern English formed. Early Modern English emerged with the help of William Caxton 's printing press, developed during the 1470s. The press stabilized English through a push towards standardization, led by Chancery Standard enthusiast and writer Richard Pynson . Early Modern English began in

4995-569: The Danelaw, this endings tended gradually to become obscured and finally lost, "simplifying English grammar" in the process. In time, the inflections melted away and the analytic pattern emerged. Viking influence on Old English is most apparent in pronouns , modals, comparatives, pronominal adverbs (like hence and together ), conjunctions, and prepositions show the most marked Danish influence. The best evidence of Scandinavian influence appears in extensive word borrowings; however, texts from

5106-418: The Middle English period varied widely. Examples of writing from this period that have survived show extensive regional variation. The more standardized Old English literary variety broke down and writing in English became fragmented and localized and was, for the most part, being improvised. By the end of the period (about 1470), and aided by the invention of the printing press by Johannes Gutenberg in 1439,

5217-675: The Middle English period, many Old English grammatical features either became simplified or disappeared altogether. Noun, adjective, and verb inflections were simplified by the reduction (and eventual elimination) of most grammatical case distinctions. Middle English also saw considerable adoption of Anglo-Norman vocabulary, especially in the areas of politics, law, the arts, and religion, as well as poetic and emotive diction. Conventional English vocabulary remained primarily Germanic in its sources, with Old Norse influences becoming more apparent. Significant changes in pronunciation took place, particularly involving long vowels and diphthongs, which in

5328-557: The Nightingale . Some scholars have defined "Early Middle English" as encompassing English texts up to 1350. This longer time frame would extend the corpus to include many Middle English Romances (especially those of the Auchinleck manuscript c.  1330 ). Gradually, the wealthy and the government Anglicised again, although Norman (and subsequently French ) remained the dominant language of literature and law until

5439-644: The Norse speakers' inability to reproduce the ending sounds of English words influenced Middle English's loss of inflectional endings. Important texts for the reconstruction of the evolution of Middle English out of Old English are the Peterborough Chronicle , which continued to be compiled up to 1154; the Ormulum , a biblical commentary probably composed in Lincolnshire in the second half of

5550-544: The Old English -eþ , Midland dialects showing -en from about 1200, and Northern forms using -es in the third person singular as well as the plural. The past tense of weak verbs was formed by adding an -ed(e) , -d(e) , or -t(e) ending. The past-tense forms, without their personal endings, also served as past participles with past-participle prefixes derived from Old English: i- , y- , and sometimes bi- . Strong verbs , by contrast, formed their past tense by changing their stem vowel (e.g., binden became bound ,

5661-530: The SARS-CoV-2 virus entered into human populations through natural zoonosis , similar to the SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Social and environmental factors including climate change , natural ecosystem destruction and wildlife trade increased the likelihood of such zoonotic spillover . The disease quickly spread worldwide, resulting in

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5772-475: The WHO declared that another distinctive variant, JN.1, had emerged as a "variant of interest". Though the WHO expected an increase in cases globally, particularly for countries entering winter, the overall global health risk was considered low. The SARS-CoV-2 virus can infect a wide range of cells and systems of the body. COVID‑19 is most known for affecting the upper respiratory tract (sinuses, nose, and throat) and

5883-759: The WHO on 11 February 2020 with COVID-19 being shorthand for "coronavirus disease 2019". The WHO additionally uses "the COVID‑19 virus" and "the virus responsible for COVID‑19" in public communications. The symptoms of COVID-19 are variable depending on the type of variant contracted, ranging from mild symptoms to a potentially fatal illness. Common symptoms include coughing , fever , loss of smell (anosmia) and taste (ageusia), with less common ones including headaches , nasal congestion and runny nose , muscle pain , sore throat , diarrhea , eye irritation , and toes swelling or turning purple, and in moderate to severe cases, breathing difficulties . People with

5994-551: The WHO recommended the labelling of variants using letters of the Greek alphabet , for example, Alpha , Beta , Delta , and Gamma , giving the justification that they "will be easier and more practical to discussed by non-scientific audiences". Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR). The Pango tool groups variants into lineages , with many circulating lineages being classed under

6105-515: The brain connected to the sense of smell compared with uninfected individuals, and the overall effect on the brain was equivalent on average to at least one extra year of normal ageing; infected individuals also scored lower on several cognitive tests. All effects were more pronounced among older ages. The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric , duodenal and rectal epithelium as well as endothelial cells and enterocytes of

6216-591: The brain found as complications leading to death in people infected with COVID‑19. Infection may initiate a chain of vasoconstrictive responses within the body, including pulmonary vasoconstriction – a possible mechanism in which oxygenation decreases during pneumonia. Furthermore, damage of arterioles and capillaries was found in brain tissue samples of people who died from COVID‑19. COVID‑19 may also cause substantial structural changes to blood cells , sometimes persisting for months after hospital discharge. A low level of blood lymphocytess may result from

6327-428: The brains of those who have died from COVID‑19, but these results need to be confirmed. While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain. The virus may also enter the bloodstream from the lungs and cross the blood–brain barrier to gain access to

6438-409: The clear jelly liquid found in lung autopsies of people who died of COVID-19. One possibility addressed in medical research is that hyuralonic acid (HA) could be the leading factor for this observation of the clear jelly liquid found in the lungs, in what could be hyuralonic storm, in conjunction with cytokine storm . One common symptom, loss of smell, results from infection of the support cells of

6549-507: The comparative and superlative (e.g., greet , great; gretter , greater). Adjectives ending in -ly or -lich formed comparatives either with -lier , -liest or -loker , -lokest . A few adjectives also displayed Germanic umlaut in their comparatives and superlatives, such as long , lenger . Other irregular forms were mostly the same as in modern English. Middle English personal pronouns were mostly developed from those of Old English , with

6660-406: The data. Of people who show symptoms, 81% develop only mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging) that require hospitalization, and 5% of patients develop critical symptoms ( respiratory failure , septic shock , or multiorgan dysfunction ) requiring ICU admission. At least a third of

6771-486: The development of the Chancery Standard in the 15th century, orthography became relatively standardised in a form based on the East Midlands-influenced speech of London. Spelling at the time was mostly quite regular . (There was a fairly consistent correspondence between letters and sounds.) The irregularity of present-day English orthography is largely due to pronunciation changes that have taken place over

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6882-495: The different dialects, that was based chiefly on the speech of the East Midlands but also influenced by that of other regions. The writing of this period, however, continues to reflect a variety of regional forms of English. The Ayenbite of Inwyt , a translation of a French confessional prose work, completed in 1340, is written in a Kentish dialect . The best known writer of Middle English, Geoffrey Chaucer , wrote in

6993-658: The disease. Complications may include pneumonia , acute respiratory distress syndrome (ARDS), multi-organ failure , septic shock , and death. Cardiovascular complications may include heart failure, arrhythmias (including atrial fibrillation ), heart inflammation , thrombosis , particularly venous thromboembolism , and endothelial cell injury and dysfunction. Approximately 20–30% of people who present with COVID‑19 have elevated liver enzymes , reflecting liver injury. Neurologic manifestations include seizure , stroke, encephalitis , and Guillain–Barré syndrome (which includes loss of motor functions ). Following

7104-531: The double consonant represented a sound that was (or had previously been) geminated (i.e., had genuinely been "doubled" and would thus have regularly blocked the lengthening of the preceding vowel). In other cases, by analogy, the consonant was written double merely to indicate the lack of lengthening. The basic Old English Latin alphabet consisted of 20 standard letters plus four additional letters: ash ⟨æ⟩ , eth ⟨ð⟩ , thorn ⟨þ⟩ , and wynn ⟨ƿ⟩ . There

7215-468: The end of the Middle English period only the strong -'s ending (variously spelled) was in use. Some formerly feminine nouns, as well as some weak nouns, continued to make their genitive forms with -e or no ending (e.g., fole hoves , horses' hooves), and nouns of relationship ending in -er frequently have no genitive ending (e.g., fader bone , "father's bane"). The strong -(e)s plural form has survived into Modern English. The weak -(e)n form

7326-418: The exception of the third person plural, a borrowing from Old Norse (the original Old English form clashed with the third person singular and was eventually dropped). Also, the nominative form of the feminine third person singular was replaced by a form of the demonstrative that developed into sche (modern she ), but the alternative heyr remained in some areas for a long time. As with nouns, there

7437-721: The expression of ACE-2, thereby facilitating the SARS-Cov2 virus to enter cells and to replicate. A competition of negative feedback loops (via protective effects of interferon alpha) and positive feedback loops (via upregulation of ACE-2) is assumed to determine the fate of patients suffering from COVID-19. Additionally, people with COVID‑19 and acute respiratory distress syndrome (ARDS) have classical serum biomarkers of CRS, including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer , and ferritin . Systemic inflammation results in vasodilation , allowing inflammatory lymphocytic and monocytic infiltration of

7548-428: The eyes, nose, or mouth. The risk is highest when people are in close proximity, but small airborne particles containing the virus can remain suspended in the air and travel over longer distances, particularly indoors. Transmission can also occur when people touch their eyes, nose or mouth after touching surfaces or objects that have been contaminated by the virus. People remain contagious for up to 20 days and can spread

7659-525: The face. While drugs have been developed to inhibit the virus, the primary treatment is still symptomatic , managing the disease through supportive care , isolation , and experimental measures . During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus", with the disease sometimes called "Wuhan pneumonia". In the past, many diseases have been named after geographical locations, such as

7770-523: The heart. ACE2 receptors are highly expressed in the heart and are involved in heart function. A high incidence of thrombosis and venous thromboembolism occurs in people transferred to intensive care units with COVID‑19 infections, and may be related to poor prognosis. Blood vessel dysfunction and clot formation (as suggested by high D-dimer levels caused by blood clots) may have a significant role in mortality, incidents of clots leading to pulmonary embolisms , and ischaemic events (strokes) within

7881-503: The host cell. Following viral entry, COVID‑19 infects the ciliated epithelium of the nasopharynx and upper airways. Autopsies of people who died of COVID‑19 have found diffuse alveolar damage , and lymphocyte-containing inflammatory infiltrates within the lung. From the CT scans of COVID-19 infected lungs, white patches were observed containing fluid known as ground-glass opacity (GGO) or simply ground glass. This tended to correlate with

7992-412: The indicator of the longer and changed pronunciation of ⟨a⟩ . In fact, vowels could have this lengthened and modified pronunciation in various positions, particularly before a single consonant letter and another vowel or before certain pairs of consonants. A related convention involved the doubling of consonant letters to show that the preceding vowel was not to be lengthened. In some cases,

8103-528: The infection, children may develop paediatric multisystem inflammatory syndrome , which has symptoms similar to Kawasaki disease , which can be fatal. In very rare cases, acute encephalopathy can occur, and it can be considered in those who have been diagnosed with COVID‑19 and have an altered mental status. According to the US Centers for Disease Control and Prevention , pregnant women are at increased risk of becoming seriously ill from COVID‑19. This

8214-583: The lack of written evidence from the areas of Danish control, as the majority of written sources from Old English were produced in the West Saxon dialect spoken in Wessex , the heart of Anglo-Saxon political power at the time. The Norman Conquest of England in 1066 saw the replacement of the top levels of the English-speaking political and ecclesiastical hierarchies by Norman rulers who spoke

8325-760: The language of government and law can be seen in the abundance of Modern English words for the mechanisms of government that are derived from Anglo-Norman, such as court , judge , jury , appeal , and parliament . There are also many Norman-derived terms relating to the chivalric cultures that arose in the 12th century, an era of feudalism , seigneurialism , and crusading . Words were often taken from Latin, usually through French transmission. This gave rise to various synonyms, including kingly (inherited from Old English), royal (from French, inherited from Vulgar Latin), and regal (from French, which borrowed it from Classical Latin). Later French appropriations were derived from standard, rather than Norman, French. Examples of

8436-403: The later Middle English period began to undergo the Great Vowel Shift . Little survives of early Middle English literature , due in part to Norman domination and the prestige that came with writing in French rather than English. During the 14th century, a new style of literature emerged with the works of writers including John Wycliffe and Geoffrey Chaucer , whose Canterbury Tales remains

8547-454: The lower respiratory tract (windpipe and lungs). The lungs are the organs most affected by COVID‑19 because the virus accesses host cells via the receptor for the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant on the surface of type II alveolar cells of the lungs. The virus uses a special surface glycoprotein called a " spike " to connect to the ACE2 receptor and enter

8658-409: The lung and the heart. In particular, pathogenic GM-CSF-secreting T cells were shown to correlate with the recruitment of inflammatory IL-6-secreting monocytes and severe lung pathology in people with COVID‑19. Lymphocytic infiltrates have also been reported at autopsy. Multiple viral and host factors affect the pathogenesis of the virus. The S-protein , otherwise known as the spike protein,

8769-417: The masculine accusative, genitive, and dative, the feminine dative, and the plural genitive. The Owl and the Nightingale adds a final -e to all adjectives not in the nominative, here only inflecting adjectives in the weak declension (as described above). Comparatives and superlatives were usually formed by adding -er and -est . Adjectives with long vowels sometimes shortened these vowels in

8880-447: The moment a person first becomes infected and the appearance of the first symptoms. The median delay for COVID-19 is four to five days possibly being infectious on 1–4 of those days. Most symptomatic people experience symptoms within two to seven days after exposure, and almost all will experience at least one symptom within 12 days. Most people recover from the acute phase of the disease. However, some people continue to experience

8991-427: The more complex system of inflection in Old English : Nouns of the weak declension are primarily inherited from Old English n -stem nouns but also from ō -stem, wō -stem, and u -stem nouns, which did not inflect in the same way as n -stem nouns in Old English, but joined the weak declension in Middle English. Nouns of the strong declension are inherited from the other Old English noun stem classes. Some nouns of

9102-460: The most studied and read work of the period. The transition from Late Old English to Early Middle English had taken place by the 1150s to 1180s, the period when the Augustinian canon Orrm wrote the Ormulum , one of the oldest surviving texts in Middle English. The influence of Old Norse aided the development of English from a synthetic language with relatively free word order to

9213-693: The old insular g and the Carolingian g (modern g ), the former continued in use as a separate letter, known as yogh , written ⟨ȝ⟩ . This was adopted for use to represent a variety of sounds: [ɣ], [j], [dʒ], [x], [ç] , while the Carolingian g was normally used for [g]. Instances of yogh were eventually replaced by ⟨j⟩ or ⟨y⟩ and by ⟨gh⟩ in words like night and laugh . In Middle Scots , yogh became indistinguishable from cursive z , and printers tended to use ⟨z⟩ when yogh

9324-480: The olfactory epithelium , with subsequent damage to the olfactory neurons . The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. It is clear that many people with COVID-19 exhibit neurological or mental health issues . The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues . However, SARS-CoV-2 has been detected at low levels in

9435-423: The other case endings disappeared in the Early Middle English period, including most of the roughly one dozen forms of the definite article ("the"). The dual personal pronouns (denoting exactly two) also disappeared from English during this period. The loss of case endings was part of a general trend from inflections to fixed word order that also occurred in other Germanic languages (though more slowly and to

9546-488: The peak viral load in upper respiratory tract samples occurs close to the time of symptom onset and declines after the first week after symptoms begin. Current evidence suggests a duration of viral shedding and the period of infectiousness of up to ten days following symptom onset for people with mild to moderate COVID-19, and up to 20 days for persons with severe COVID-19, including immunocompromised people. Severe acute respiratory syndrome coronavirus   2 (SARS-CoV-2)

9657-411: The people who are infected with the virus do not develop noticeable symptoms at any point in time. These asymptomatic carriers tend not to get tested and can still spread the disease. Other infected people will develop symptoms later (called "pre-symptomatic") or have very mild symptoms and can also spread the virus. As is common with infections, there is a delay, or incubation period , between

9768-521: The period in Scandinavia and Northern England do not provide certain evidence of an influence on syntax. However, at least one scholarly study of this influence shows that Old English may have been replaced entirely by Norse, by virtue of the change from Old English to Norse syntax. While the Old Norse influence was strongest in the dialects under Danish control that composed the southern part of

9879-575: The princely position of dragoman of the fleet served under the Ottoman admiral having administration of the Aegean islands and the Anatolian coast. Modern acknowledgement of the phrase Amīr -al-Baḥr (أمير البحر) meaning "Prince of the Sea" includes a speech made in an official U.S. military ceremony conducted in an Arabic port, and a news article published by an Arabic news outlet: On 24 May 2012, in

9990-416: The respiratory tract, people with severe COVID‑19 have symptoms of systemic hyperinflammation. Clinical laboratory findings of elevated IL‑2 , IL‑6 , IL‑7 , as well as the following suggest an underlying immunopathology: Interferon alpha plays a complex, Janus-faced role in the pathogenesis of COVID-19. Although it promotes the elimination of virus-infected cells, it also upregulates

10101-569: The resulting doublet pairs include warden (from Norman) and guardian (from later French; both share a common ancestor loaned from Germanic). The end of Anglo-Saxon rule did not result in immediate changes to the language. The general population would have spoken the same dialects as they had before the Conquest. Once the writing of Old English came to an end, Middle English had no standard language, only dialects that evolved individually from Old English. Early Middle English (1150–1350) has

10212-417: The sea, q. d. prince of the sea . The word is written both with and without the d, in other languages, as well as our own. Barb. Lat. admirallus and amiralius. V. Ducange. Barb. Græc. ἄμηρχλιος. V. Meursii Gloss. Græco-Barbarum, edit. 1610. p. 29. Fr. admiral and amiral. Dan. the same. Germ. ammiral. Dutch, admirael or ammirael. Ital. ammiraglio. Sp. almirante. Minsheu, in his Spanish Dictionary, says 'almiralle

10323-740: The second half of the 14th century in the emerging London dialect, although he also portrays some of his characters as speaking in northern dialects, as in " The Reeve's Tale ". In the English-speaking areas of lowland Scotland , an independent standard was developing, based on the Northumbrian dialect . This would develop into what came to be known as the Scots language . A large number of terms for abstract concepts were adopted directly from scholastic philosophical Latin (rather than via French). Examples are "absolute", "act", "demonstration", and "probable". The Chancery Standard of written English emerged c.  1430 in official documents that, since

10434-458: The second person singular in -(e)st (e.g., þou spekest , "thou speakest"), and the third person singular in -eþ (e.g., he comeþ , "he cometh/he comes"). ( þ (the letter "thorn") is pronounced like the unvoiced th in "think", but under certain circumstances, it may be like the voiced th in "that"). The following table illustrates a typical conjugation pattern: Plural forms vary strongly by dialect, with Southern dialects preserving

10545-409: The strong type have an -e in the nominative/accusative singular, like the weak declension, but otherwise strong endings. Often, these are the same nouns that had an -e in the nominative/accusative singular of Old English (they, in turn, were inherited from Proto-Germanic ja -stem and i -stem nouns). The distinct dative case was lost in early Middle English, and although the genitive survived, by

10656-408: The term means "One having, holding, or possessing, command; a commander; a governor; a lord; a prince, or king." While other Greek words of the period existed to indicate "belonging to the sea," or "of the sea," the now obsolete Gr. ἄλιος mentioned in Johnson's Dictionary is expressly defined as "of the sea, Lat. marinus, epith. of sea-gods , nymphs , etc." Though there are multiple meanings for

10767-757: The term was in use for the Greco-Arab naval leaders (e.g. Christodulus ) in the Norman-Arab-Byzantine culture of Norman Sicily , which had formerly been ruled by Arabs, at least by the early 11th century. During this time, the Norman Roger II of Sicily (1095–1154) employed a Greek Christian, known as George of Antioch , who previously had served as a naval commander for several North African Muslim rulers. Roger styled George in Abbasid fashion as Amir of Amirs , or Amīr al-Umarāʾ, with

10878-551: The title becoming Latinized in the 13th century as ammiratus ammiratorum . The Sicilians and later the Genoese took the first two parts of the term from their Aragon opponents and used them as one word, amiral . . The French gave their sea commanders similar titles while in Portuguese and Spanish the word changed to almirante . As the word was used by people speaking Latin or Latin-based languages it gained

10989-412: The very pronunciation of ναύαρχος demonstrates that it is not a part of the etymology for the English word "admiral." The word "admiral" has come to be almost exclusively associated with the highest naval rank in most of the world's navies , equivalent to the army rank of general . However, this was not always the case; for example, in some European countries prior to the end of World War II , admiral

11100-516: The virus acting through ACE2-related entry into lymphocytes. Another common cause of death is complications related to the kidneys . Early reports show that up to 30% of hospitalised patients both in China and in New York have experienced some injury to their kidneys, including some persons with no previous kidney problems. Although SARS-CoV-2 has a tropism for ACE2-expressing epithelial cells of

11211-752: The virus even if they do not develop symptoms. Testing methods for COVID-19 to detect the virus's nucleic acid include real-time reverse transcription polymerase chain reaction (RT‑PCR), transcription-mediated amplification , and reverse transcription loop-mediated isothermal amplification (RT‑LAMP) from a nasopharyngeal swab . Several COVID-19 vaccines have been approved and distributed in various countries, many of which have initiated mass vaccination campaigns . Other preventive measures include physical or social distancing , quarantining , ventilation of indoor spaces, use of face masks or coverings in public, covering coughs and sneezes, hand washing , and keeping unwashed hands away from

11322-509: The virus is carried out through virus-laden fluid particles, or droplets, which are created in the respiratory tract, and they are expelled by the mouth and the nose. There are three types of transmission: "droplet" and "contact", which are associated with large droplets, and "airborne", which is associated with small droplets. If the droplets are above a certain critical size, they settle faster than they evaporate , and therefore they contaminate surfaces surrounding them. Droplets that are below

11433-425: Was indicated by agreement of articles and pronouns (e.g., þo ule "the feminine owl") or using the pronoun he to refer to masculine nouns such as helm ("helmet"), or phrases such as scaft stærcne (strong shaft), with the masculine accusative adjective ending -ne . Single-syllable adjectives added -e when modifying a noun in the plural and when used after the definite article ( þe ), after

11544-559: Was not available in their fonts; this led to new spellings (often giving rise to new pronunciations), as in McKenzie , where the ⟨z⟩ replaced a yogh, which had the pronunciation /j/ . Coronavirus disease 2019 Coronavirus disease 2019 ( COVID-19 ) is a contagious disease caused by the coronavirus SARS-CoV-2 . The first known case was identified in Wuhan , China, in December 2019. Most scientists believe

11655-520: Was not yet a distinct j , v , or w , and Old English scribes did not generally use k , q , or z . Ash was no longer required in Middle English, as the Old English vowel /æ/ that it represented had merged into /a/ . The symbol nonetheless came to be used as a ligature for the digraph ⟨ae⟩ in many words of Greek or Latin origin, as did ⟨œ⟩ for ⟨oe⟩ . Eth and thorn both represented /θ/ or its allophone / ð / in Old English. Eth fell out of use during

11766-417: Was ousted by it in most dialects by the 15th. The following table shows some of the various Middle English pronouns. Many other variations are noted in Middle English sources because of differences in spellings and pronunciations at different times and in different dialects. As a general rule, the indicative first person singular of verbs in the present tense ended in -e (e.g., ich here , "I hear"),

11877-475: Was some inflectional simplification (the distinct Old English dual forms were lost), but pronouns, unlike nouns, retained distinct nominative and accusative forms. Third person pronouns also retained a distinction between accusative and dative forms, but that was gradually lost: The masculine hine was replaced by him south of the River Thames by the early 14th century, and the neuter dative him

11988-667: Was spoken after the Norman Conquest of 1066, until the late 15th century. The English language underwent distinct variations and developments following the Old English period. Scholarly opinion varies, but the University of Valencia states the period when Middle English was spoken as being from 1150 to 1500. This stage of the development of the English language roughly coincided with the High and Late Middle Ages . Middle English saw significant changes to its vocabulary, grammar, pronunciation, and orthography . Writing conventions during

12099-411: Was substantive, pervasive, and of a democratic character. Like close cousins, Old Norse and Old English resembled each other, and with some words and grammatical structures in common, speakers of each language roughly understood each other, but according to historian Simeon Potler the main difference lied on their inflectional endings, which led to much confusion within the mixed population that existed in

12210-415: Was the third highest naval rank after general admiral and grand admiral . The rank of admiral has also been subdivided into various grades, several of which are historically extinct while others remain in use in most present-day navies. The Royal Navy used the colours red, white, and blue, in descending order to indicate seniority of its admirals until 1864; for example, Horatio Nelson 's highest rank

12321-482: Was vice-admiral of the white. The generic term for these naval equivalents of army generals is flag officer . Some navies have also used army-type titles for them, such as the Cromwellian "general at sea". While the rank is used in most of NATO countries, it is ranked differently depending on the country. Middle English Middle English (abbreviated to ME ) is a form of the English language that

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