BTG Limited is an international specialist healthcare company that is developing and commercialising products targeting critical care, cancer and other disorders. The current name was adopted when the British Technology Group changed its name on 27 May 1998. BTG was a constituent of the FTSE 250 Index until it was acquired by Boston Scientific in August 2019.
16-639: In 1948, the National Research Development Corporation was formed with the purpose of commercialising innovations that arose from public funded research . This was complemented, in November 1975, by the establishment of the National Enterprise Board to implement the then-Government's policy of moving public sector industry into commercial private enterprise. These two organisations were merged by
32-521: A meal cooked in a 10% cypermethrin/oil mix that was mistakenly used for cooking oil. Shortly after the meal, the victim experienced nausea, prolonged vomiting, stomach pains, and diarrhea which progressed to convulsions, unconsciousness and coma. Other family members exhibited milder symptoms and survived after hospital treatment. It may cause allergic skin reactions in humans. Excessive exposure can cause nausea, headache, muscle weakness, salivation, shortness of breath and seizures. In humans, cypermethrin
48-715: A perceived need at the time to exploit the many products that had been developed during World War II by the Defence Research Establishments . It was set up by the Board of Trade under the Development of Inventions Act 1948 and the first managing director was Lord Giffard . The NRDC was established in India in 1953 to help develop and promote technologies developed at various national R&D institutions. The first commercial size hovercraft ,
64-548: Is a synthetic pyrethroid used as an insecticide in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. It behaves as a fast-acting neurotoxin in insects. It is easily degraded on soil and plants but can be effective for weeks when applied to indoor inert surfaces. It is a non-systemic and non-volatile insecticide that acts by contact and ingestion, used in agriculture and in pest control products. Exposure to sunlight, water and oxygen will accelerate its decomposition. Cypermethrin
80-444: Is deactivated by enzymatic hydrolysis to several carboxylic acid metabolites, which are eliminated in the urine. Worker exposure to the chemical can be monitored by measurement of the urinary metabolites, while severe overdosage may be confirmed by quantitation of cypermethrin in blood or plasma. Cypermethrin is very toxic to cats which cannot tolerate the therapeutic doses for dogs. This is associated with UGT1A6 deficiency in cats,
96-675: Is highly toxic to fish, bees and aquatic insects, according to the National Pesticide Information Center (NPIC) (previously National Pesticides Telecommunication Network) in the USA . It is found in many household ant and cockroach killers, including Raid , Ortho , Combat , ant chalk , and some products of Baygon in Southeast Asia . Cypermethrin is used in agriculture to control ectoparasites which infest cattle, sheep, and poultry. Cypermethrin
112-466: Is moderately toxic through skin contact or ingestion. It may cause irritation to the skin and eyes. Symptoms of dermal exposure include numbness, tingling, itching, burning sensation, loss of bladder control, incoordination, seizures and possible death. Pyrethroids may adversely affect the central nervous system. Human volunteers given dermal doses of 130 μg/cm on the earlobe experienced local tingling and burning sensations. One man died after eating
128-699: The SR.N1 , was built under a contract let by the NRDC to Saunders-Roe in 1958. In 1981, the NRDC was combined with the National Enterprise Board ('NEB') to form the British Technology Group ('BTG'). Typically the NRDC would patent the product for commercial exploitation and earn royalties as private sector companies generated sales from those products. Examples of such products include carbon fibre , asbestos - plastic composites and developments in semi-conductor technology . The development of
144-517: The hovercraft would also not have taken place without the involvement of the NRDC. In the 1970s, a team of Rothamsted Research scientists discovered three pyrethroids suitable for use as insecticides , namely permethrin , cypermethrin and deltamethrin . These compounds were subsequently licensed as NRDC 143, 149 and 161 respectively, to companies which then manufactured them for use worldwide. Cypermethrin Cypermethrin ( CP )
160-596: The Government in 1981 to form a new, non-statutory body called the British Technology Group . It acted principally to license and commercialise the use of publicly funded developments. The Group was put onto a statutory footing in the British Technology Group Act 1991 with HM Treasury initially being the only shareholder. Subsequently, in March 1992, Cinven arranged a management buy-out from
176-676: The Government. The company later floated on the London Stock Exchange in 1995. Three years later, on 27 May 1998, the Group adopted its present name. It now focuses its work on developing and commercialising medical innovations. Since acquiring the commercialisation rights to magnetic resonance imaging (MRI) (under a revenue share scheme) in 1983, BTG has come to license a large part of the world market in MRI, including licensees such as General Electric and Philips . BTG plc completed
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#1732791153385192-601: The United States and as BTG International Ltd. in the United Kingdom. National Research Development Corporation The National Research Development Corporation ( NRDC ) was a non-departmental government body established by the British Government to transfer technology from the public sector to the private sector. The NRDC was established by Attlee's Labour government in 1948 to meet
208-809: The acquisition of Protherics PLC in December 2008 and of Biocompatibles International plc in January 2011. In May 2016 BTG plc acquired the Israeli company Galil Medical for US$ 110 million. In September 2018, BTG plc acquired Novate Medical for up to $ 150 million. In late November 2018 Boston Scientific announced it would acquire BTG for $ 4.2 billion. The transaction was due to complete in August 2019. BTG earns revenues from specialty pharmaceutical and interventional medicine product sales and on royalties from partnered products. It trades as BTG International Inc. in
224-523: The enzyme responsible for metabolizing cypermethrin. As a consequence, cypermethrin remains much longer in the cat's organs than in dogs or other mammals and can be fatal in large doses. In male rats cypermethrin has been shown to exhibit a toxic effect on the reproductive system by Elbetieha et al. 2001. In another result, after 15 days of continual dosing, both androgen receptor levels and serum testosterone levels were significantly reduced. These data suggested that cypermethrin can induce impairments of
240-557: The proportion of abnormal sperm increases. It causes genetic damage: chromosomal abnormalities increased in bone marrow and spleen cells when mice were exposed to cypermethrin. Cypermethrin is classified as a possible human carcinogen , because it causes an increase in the frequency of lung tumors in female mice. Cypermethrin has been linked to an increase in bone marrow micronuclei in both mice and humans. One study showed that cypermethrin inhibits “gap junctional intercellular communication”, which plays an important role in cell growth and
256-475: The structure of seminiferous tubules and spermatogenesis in male rats at high doses. Long-term exposure to cypermethrin during adulthood is found to induce dopaminergic neurodegeneration in rats, and postnatal exposure enhances the susceptibility of animals to dopaminergic neurodegeneration if rechallenged during adulthood. If exposed to cypermethrin during pregnancy, rats give birth to offspring with developmental delays. In male rats exposed to cypermethrin,
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