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Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides . It is a yellow crystalline solid that has been used to dye wool.

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31-501: Granadilla is a flowering plant species of genus Passiflora , or the fruit of these plants ( passion fruit ). It is often confused with passion fruit, and the term often refers specifically to the fruit of Passiflora ligularis , although other species such as the Passiflora quadrangularis (giant granadilla) are included. Granadilla may also refer to: Passiflora About 550, see list Passiflora , known also as

62-469: A distribution centered on Mexico. Supersection Auriculata includes eight species from South America, one of which is also found in Central America. Supersection Multiflora includes nineteen species. Supersection Decaloba includes 123 species. Passiflora has a largely neotropic distribution, unlike other genera in the family Passifloraceae , which includes more Old World species (such as

93-483: A long history of use as a traditional medicine by Native Americans in North America and were adapted by European colonists . The fresh or dried leaves of maypop are used to make a tea that is used as a sedative . Passionflower as dried powder or an extract is used as a dietary supplement . There is insufficient clinical evidence for using passionflower to treat any medical condition. Passionflower

124-680: A seemingly crowded leaf), extrafloral nectaries , trichomes , variegation , and chemical defenses. These, combined with adaptations on the part of the butterflies, were important in the foundation of coevolutionary theory . Recent studies have shown that passiflora both grow faster and protect themselves better in high-nitrogen soils. In low-nitrogen environments, passiflora focus on growth rather than defense and are more vulnerable to herbivores. The following lepidoptera larvae are known to feed on Passiflora : The generally high pollinator and parasite specificity in Passiflora may have led to

155-420: A sticky fluid. Many small insects get stuck to this and get digested to nutrient -rich goo by proteases and acid phosphatases . Since the insects usually killed are rarely major pests , this passion flower seems to be a protocarnivorous plant . Banana passion flower or "banana poka" ( P. tarminiana ), originally from Central Brazil , is an invasive weed , especially on the islands of Hawaii . It

186-513: Is classified as generally recognized as safe for use as a food ingredient in the U.S. The passion in passion flower purportedly refers to the passion of Jesus in Christian theology ; the word passion comes from the Latin passio , meaning 'suffering'. In the 15th and 16th centuries, Spanish Christian missionaries adopted the unique physical structures of this plant, particularly

217-451: Is commonly spread by feral pigs eating the fruits. It overgrows and smothers stands of endemic vegetation, mainly on roadsides. Blue passion flower ( P. caerulea ) is an invasive species in Spain and considered likely to threaten ecosystems there. On the other hand, some species are endangered due to unsustainable logging and other forms of habitat destruction . For example,

248-623: Is currently being done extensively for flowers, foliage and fruit. The following hybrids and cultivars have gained the Royal Horticultural Society 's Award of Garden Merit : During the Victorian era the flower (which in all but a few species lasts only one day) was very popular, and many hybrids were created using the winged-stem passion flower ( P. alata ), the blue passion flower ( P. caerulea ) and other tropical species. Many cool-growing Passiflora from

279-489: Is known as Krishnakamala because of its dark violet blue colour which resembles Bhagwan Krishna . Apigenin Apigenin is found in many fruits and vegetables, but parsley , celery , celeriac , and chamomile tea are the most common sources. Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids . Dried parsley can contain about 45  mg  apigenin/gram of

310-469: Is the most species rich genus of both the family Passifloraceae and the tribe Passifloreae. With over 550 species, an extensive hierarchy of infrageneric ranks is required to represent the relationships of the species. The infrageneric classification of Passiflora not only uses the widely used ranks of subgenus, section and series, but also the rank of supersection. The New World species of Passiflora were first divided among 22 subgenera by Killip (1938) in

341-412: The amino acid α- alanine . Esters like ethyl butyrate , ethyl caproate , n - hexyl butyrate and n - hexyl caproate give the fruits their flavor and appetizing smell. Sugars , contained mainly in the fruit, are most significantly d- fructose , d- glucose and raffinose . Among enzymes , Passiflora was found to be rich in catalase , pectin methylesterase and phenolase . Passiflora

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372-647: The blue passion flower ( P. caerulea ) now grows wild in Spain. The purple passionfruit ( P. edulis ) and its yellow relative flavicarpa have been introduced in many tropical regions as commercial crops. Passion flowers have floral structures adapted for biotic pollination . Pollinators of Passiflora include bumblebees , carpenter bees (e.g., Xylocopa sonorina ), wasps , bats , and hummingbirds (especially hermits such as Phaethornis ); some others are additionally capable of self-pollination . Passiflora often exhibit high levels of pollinator specificity, which has led to frequent coevolution across

403-425: The passion flowers or passion vines , is a genus of about 550 species of flowering plants , the type genus of the family Passifloraceae . They are mostly tendril-bearing vines , with some being shrubs or trees . They can be woody or herbaceous . Passion flowers produce regular and usually showy flowers with a distinctive corona . There can be as many as eight concentric coronal series, as in

434-513: The two-flowered passion flower ( P. biflora ) has been sequenced . Most species have round or elongated edible fruit. A native source of beta-Carbolines (e.g., passion flower in North America) is mixed with Desmanthus illinoensis (Illinois bundleflower) root bark to produce a hallucinogenic drink called prairiehuasca, which is an analog of the shamanic brew ayahuasca . Passiflora incarnata (maypop) leaves and roots have

465-758: The Andes Mountains can be grown successfully for their beautiful flowers and fruit in cooler Mediterranean climates, such as the Monterey Bay and San Francisco in California and along the western coast of the U.S. into Canada . One blue passion flower or hybrid even grew to large size at Malmö Central Station in Sweden . Passion flowers have been a subject of studies investigating extranuclear inheritance ; paternal inheritance of chloroplast DNA has been documented in this genus. The plastome of

496-878: The Chilean passion flower ( P. pinnatistipula ) is a rare vine growing in the Tropical Andes southwards from Venezuela between 2,500 and 3,800 metres (8,200 and 12,500 ft) in altitude, and in Coastal Central Chile, where it only occurs in a few tens of square kilometres of fog forest by the sea, near Zapallar. P. pinnatistipula has a round fruit, unusual in Tacsonia group species like banana passion flower and P. mixta , with their elongated tubes and brightly red to rose-colored petals. Notable and sometimes economically significant pathogens of Passiflora are several sac fungi of

527-630: The Roman Catholic heartland, the regularly shaped flowers have reminded people of the face of a clock . In Israel they are known as "clock-flower" ( שעונית ) and in Greece as "clock plant" ( ρολογιά ); in Japan too, they are known as tokeisō ( 時計草 , 'clock plant') . In Hawaiian, they are called lilikoʻi ; lī is a string used for tying fabric together, such as a shoelace , and liko means 'to spring forth leave'. In India , it

558-464: The activity of endogenous antioxidant enzymes such as SOD and CAT, helping to reduce oxidative stress. Apigenin is biosynthetically derived from the general phenylpropanoid pathway and the flavone synthesis pathway. The phenylpropanoid pathway starts from the aromatic amino acids L-phenylalanine or L-tyrosine , both products of the Shikimate pathway . When starting from L-phenylalanine, first

589-490: The amino acid is non-oxidatively deaminated by phenylalanine ammonia lyase (PAL) to make cinnamate, followed by oxidation at the para position by cinnamate 4-hydroxylase (C4H) to produce p -coumarate. As L-tyrosine is already oxidized at the para position, it skips this oxidation and is simply deaminated by tyrosine ammonia lyase (TAL) to arrive at p -coumarate. To complete the general phenylpropanoid pathway, 4-coumarate CoA ligase (4CL) substitutes coenzyme A (CoA) at

620-518: The carboxy group of p -coumarate. Entering the flavone synthesis pathway, the type III polyketide synthase enzyme chalcone synthase (CHS) uses consecutive condensations of three equivalents of malonyl CoA followed by aromatization to convert p -coumaroyl-CoA to chalcone . Chalcone isomerase (CHI) then isomerizes the product to close the pyrone ring to make naringenin . Finally, a flavanone synthase (FNS) enzyme oxidizes naringenin to apigenin. Two types of FNS have previously been described; FNS I,

651-506: The case of P. xiikzodz . The flower is pentamerous (except for a few Southeast Asian species) and ripens into an indehiscent fruit with numerous seeds. The fruit ranges from 5–20 centimetres (2–8 in) long and 2.5–5 cm (1–2 in) across, depending upon the species or cultivar . Many species of Passiflora have been found to contain beta-carboline harmala alkaloids , some of which are MAO inhibitors . The flower and fruit have only traces of these chemicals, but

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682-431: The first monograph of the genus. More recent work has reduced these to 4, which are commonly accepted today (in order from most basally to most recently branching): Some studies have shown that the segregate Old World genera Hollrungia and Tetrapathaea are nested within Passiflora , and form a fifth subgenus ( Tetrapathaea ). Other studies support the current four subgenus classification. Relationships below

713-680: The genus Adenia ). The vast majority of Passiflora are found in Mexico, Central America, the United States and South America, although there are additional representatives in Southeast Asia and Oceania . New species continue to be identified: for example, P. xishuangbannaensis and P. pardifolia have only been known to the scientific community since 2005 and 2006, respectively. Some species of Passiflora have been naturalized beyond their native ranges. For example,

744-763: The genus Septoria (including S. passiflorae ), the undescribed proteobacterium called " Pseudomonas tomato " ( pv. passiflorae ), the Potyvirus passionfruit woodiness virus , and the Carlavirus Passiflora latent virus . Passion flower is not recommended during pregnancy because it may induce contractions. Consuming passion flower products may cause drowsiness, nausea , dizziness, abnormal heart rhythms , asthma , or rhinitis . A number of species of Passiflora are cultivated outside their natural range for both their flowers and fruit. Hundreds of hybrids have been named; hybridizing

775-530: The genus), quercetin , rutin , saponarin , shaftoside , vicenin and vitexin . Maypop, blue passion flower ( P. caerulea ), and perhaps others contain the flavone chrysin . Also documented to occur at least in some Passiflora in quantity are the hydrocarbon nonacosane and the anthocyanidin pelargonidin -3-diglycoside. The genus is rich in organic acids including formic , butyric , linoleic , linolenic , malic , myristic , oleic and palmitic acids as well as phenolic compounds, and

806-617: The genus. The sword-billed hummingbird ( Ensifera ensifera ) is a notable example: it, with its immensely elongated bill, is the sole pollinator of 37 species of high Andean Passiflora in the supersection Tacsonia . The leaves are used for feeding by the larvae of a number of species of Lepidoptera . Famously, they are exclusively targeted by many butterfly species of the tribe Heliconiini . The many defensive adaptations visible on Passiflora include diverse leaf shapes (which help disguise their identity), colored nubs (which mimic butterfly eggs and can deter Heliconians from ovipositing on

837-440: The herb, and dried chamomile flower about 3–5 mg/gram. The apigenin content of fresh parsley is reportedly 215.5 mg/100 grams, which is much higher than the next highest food source, green celery hearts providing 19.1 mg/100 grams. Apigenin competitively binds to the benzodiazepine site on GABA A receptors. There exist conflicting findings regarding how apigenin interacts with this site. Apigenin can increase

868-1248: The leaves and the roots often contain more. The most common of these alkaloids is harman , but harmaline , harmalol , harmine , and harmol are also present. The species known to bear such alkaloids include: P. actinia , P. alata (winged-stem passion flower), P. alba , P. bryonioides (cupped passion flower), P. caerulea (blue passion flower), P. capsularis , P. decaisneana , P. edulis (passion fruit), P. eichleriana , P. foetida (stinking passion flower), P. incarnata (maypop), P. quadrangularis (giant granadilla), P. suberosa , P. subpeltata and P. warmingii . Other compounds found in passion flowers are coumarins (e.g. scopoletin and umbelliferone ), maltol , phytosterols (e.g. lutenin ) and cyanogenic glycosides (e.g. gynocardin ) which render some species, i.e. P. adenopoda , somewhat poisonous. Many flavonoids and their glycosides have been found in Passiflora , including apigenin , benzoflavone , homoorientin , 7-isoorientin , isoshaftoside , isovitexin (or saponaretin ), kaempferol , lucenin , luteolin , n- orientin , passiflorine (named after

899-567: The numbers of its various flower parts, as symbols of the last days of Jesus and especially his crucifixion : The flower has been given names related to this symbolism throughout Europe since the 15th century. In Spain , it is known as espina de Cristo ('thorn of Christ'). Older Germanic names include Christus-Krone ('Christ's crown'), Christus-Strauss ('Christ's bouquet'), Dorn-Krone ('crown of thorns'), Jesus-Lijden ('Jesus' passion'), Marter ('passion') or Muttergottes-Stern ('Mother of God's star'). Outside

930-848: The subgenus level are not known with certainty and are an active area of research. The Old World species form two clades – supersection Disemma (part of subgenus Decaloba ) and subgenus Tetrapathaea . The former is composed of 21 species divided into sections Disemma (three Australian species), Holrungiella (one New Guinean species) and Octandranthus (seventeen south and east Asian species). The remaining (New World) species of subgenus Decaloba are divided into seven supersections. Supersection Pterosperma includes four species from Central America and southern Mexico. Supersection Hahniopathanthus includes five species from Central America, Mexico and northernmost South America . Supersection Cicea includes nineteen species, with apetalous flowers. Supersection Bryonioides includes twenty-one species, with

961-452: The tremendous morphological variation in the genus. It is thought to have among the highest foliar diversity among all plant genera, with leaf shapes ranging from unlobed to five-lobed frequently found on the same plant. Coevolution can be a major driver of speciation, and may be responsible for the radiation of certain clades of Passiflora such as Tacsonia . The bracts of the stinking passion flower are covered by hairs which exude

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