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116-514: The Black Death was a bubonic plague pandemic that occurred in Europe from 1346 to 1353. It was one of the most fatal pandemics in human history; as many as 50 million people perished, perhaps 50% of Europe's 14th century population. The disease is caused by the bacterium Yersinia pestis and spread by fleas and through the air. One of the most significant events in European history,

232-469: A plague outbreak in five Indian states caused an estimated 700 infections (including 52 deaths) and triggered a large migration of Indians within India as they tried to avoid the disease. It was during the 1894 Hong Kong plague outbreak that Alexandre Yersin isolated the bacterium responsible ( Yersinia pestis ), a few days after Japanese bacteriologist Kitasato Shibasaburō had isolated it. However,

348-633: A "pestilential fever" ( febris pestilentialis ) in his work On the Signs and Symptoms of Diseases ( De signis et symptomatibus aegritudium ). The phrase mors nigra , 'black death', was used in 1350 by Simon de Covino (or Couvin), a Belgian astronomer, in his poem "On the Judgement of the Sun at a Feast of Saturn" ( De judicio Solis in convivio Saturni ), which attributes the plague to an astrological conjunction of Jupiter and Saturn. His use of

464-533: A 1631 book on Danish history by J. I. Pontanus : "Commonly and from its effects, they called it the black death" ( Vulgo & ab effectu atram mortem vocitabant ). Research from 2017 suggests plague first infected humans in Europe and Asia in the Late Neolithic - Early Bronze Age . Research in 2018 found evidence of Yersinia pestis in an ancient Swedish tomb, which may have been associated with

580-576: A common morpheme-by-morpheme loan-translation is of the English word " skyscraper ", a kenning -like term which may be calqued using the word for "sky" or "cloud" and the word, variously, for "scrape", "scratch", "pierce", "sweep", "kiss", etc. At least 54 languages have their own versions of the English word. Some Germanic and Slavic languages derived their words for "translation" from words meaning "carrying across" or "bringing across", calquing from

696-515: A compound but not others. For example, the name of the Irish digital television service Saorview is a partial calque of that of the UK service " Freeview ", translating the first half of the word from English to Irish but leaving the second half unchanged. Other examples include " liverwurst " (< German Leberwurst ) and " apple strudel " (< German Apfelstrudel ). The " computer mouse "

812-464: A conjunction of planets had caused "a great pestilence in the air" ( miasma theory ). Muslim religious scholars taught that the pandemic was a "martyrdom and mercy" from God, assuring the believer's place in paradise. For non-believers, it was a punishment. Some Muslim doctors cautioned against trying to prevent or treat a disease sent by God. Others adopted preventive measures and treatments for plague used by Europeans. These Muslim doctors also depended on

928-747: A description of the disease modelled on Thucydides 's account of the 5th century BCE Plague of Athens , noting the spread of the Black Death by ship between maritime cities. Nicephorus Gregoras , while writing to Demetrios Kydones , described the rising death toll, the futility of medicine, and the panic of the citizens. The first outbreak in Constantinople lasted a year, but the disease recurred ten times before 1400. Carried by twelve Genoese galleys, plague arrived by ship in Sicily in October 1347;

1044-680: A human case of bubonic plague was reported. Officials responded by activating a city-wide plague-prevention system for the remainder of the year. Also in July 2020, in Mongolia, a teenager died from bubonic plague after consuming infected marmot meat. Yersinia pestis has been discovered in archaeological finds from the Late Bronze Age (~3800 BP ). The bacteria is identified by ancient DNA in human teeth from Asia and Europe dating from 2,800 to 5,000 years ago. Some authors have suggested that

1160-496: A large population of rats, the animals can harbor low levels of the plague infection without causing human outbreaks. With no new rat inputs being added to the population from other areas, the infection only spread to humans in very rare cases of overcrowding. After being transmitted via the bite of an infected flea, the Y. pestis bacteria become localized in an inflamed lymph node , where they begin to colonize and reproduce. Infected lymph nodes develop hemorrhages, which result in

1276-467: A role in controlling the 2003 Oran outbreak of the bubonic plague. Another means of prevention in large European cities was a city-wide quarantine to not only limit interaction with people who were infected, but also to limit the interaction with the infected rats. Several classes of antibiotic are effective in treating bubonic plague. These include aminoglycosides such as streptomycin and gentamicin , tetracyclines (especially doxycycline ), and

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1392-516: A role in increasing the transmission effectiveness of the plague. The plague resurfaced for a third time in the mid-19th century; this is also known as "the modern pandemic". Like the two previous outbreaks, this one also originated in Eastern Asia , most likely in Yunnan , a province of China, where there are several natural plague foci . The initial outbreaks occurred in the second half of

1508-527: A rue du Pipi. Pigs, cattle, chickens, geese, goats and horses roamed the streets of medieval London and Paris. Medieval homeowners were supposed to police their housefronts, including removing animal dung, but most urbanites were careless. William E. Cosner, a resident of the London suburb of Farringdon Without, received a complaint alleging that "men could not pass [by his house] for the stink [of] . . . horse dung and horse piss." One irate Londoner complained that

1624-576: A small sporadic outbreak characteristic of transmission from rodents to humans with no wide-scale impact. According to Achtman, the dating of the plague suggests that it was not carried along the Silk Road , and its widespread appearance in that region probably postdates the European outbreak. Additionally, the Silk Road had already been heavily disrupted before the spread of the Black Death; Western and Middle Eastern traders found it difficult to trade on

1740-536: A team led by Galina Eroshenko placed its origins more specifically in the Tian Shan mountains on the border between Kyrgyzstan and China. However more recent research notes that the previous sampling contained East Asian bias and that sampling since then has discovered strains of Y. pestis in the Caucasus region previously thought to be restricted to China. There is also no physical or specific textual evidence of

1856-607: A vector to jump from animals to humans. The mortality rate is highest in the summer and early fall. The successful control of rat populations in dense urban areas is essential to outbreak prevention. One example is the use of a machine called the Sulfurozador , used to deliver sulphur dioxide to eradicate the pest that spread the bubonic plague in Buenos Aires, Argentina during the early 18th century. Targeted chemoprophylaxis , sanitation , and vector control also played

1972-478: Is needed to the range of (especially non- commensal ) animals that might be involved in the transmission of plague. Archaeologist Barney Sloane has argued that there is insufficient evidence of the extinction of numerous rats in the archaeological record of the medieval waterfront in London, and that the disease spread too quickly to support the thesis that Y. pestis was spread from fleas on rats; he argues that transmission must have been person to person. This theory

2088-514: Is one of three types of plague caused by the bacterium Yersinia pestis . One to seven days after exposure to the bacteria, flu-like symptoms develop. These symptoms include fever , headaches , and vomiting , as well as swollen and painful lymph nodes occurring in the area closest to where the bacteria entered the skin. Acral necrosis , the dark discoloration of skin, is another symptom. Occasionally, swollen lymph nodes, known as " buboes ", may break open. The three types of plague are

2204-421: Is one or more infected, enlarged, and painful lymph nodes, known as buboes . Buboes associated with the bubonic plague are commonly found in the armpits, upper femoral area, groin, and neck region. These buboes will grow and become more painful over time, often to the point of bursting. Symptoms include heavy breathing, continuous vomiting of blood ( hematemesis ), aching limbs, coughing, and extreme pain caused by

2320-546: Is quite different from that of the borrowing language, or when the calque contains less obvious imagery. One system classifies calques into five groups. This terminology is not universal: Some linguists refer to a phonological calque , in which the pronunciation of a word is imitated in the other language. For example, the English word "radar" becomes the similar-sounding Chinese word 雷达 ( pinyin : léidá ), which literally means "to arrive (as fast) as thunder". Partial calques, or loan blends, translate some parts of

2436-564: Is still contested. It is speculated that rats aboard Zheng He 's ships in the 15th century may have carried the plague to Southeast Asia , India , and Africa. Research on the Delhi Sultanate and the Yuan dynasty shows no evidence of any serious epidemic in fourteenth-century India and no specific evidence of plague in 14th-century China, suggesting that the Black Death may not have reached these regions. Ole Benedictow argues that since

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2552-526: Is supported by research in 2018 which suggested transmission was more likely by body lice and fleas during the second plague pandemic . Academic debate continues, but no single alternative explanation for the plague's spread has achieved widespread acceptance. Many scholars arguing for Y. pestis as the major agent of the pandemic suggest that its extent and symptoms can be explained by a combination of bubonic plague with other diseases, including typhus , smallpox , and respiratory infections . In addition to

2668-444: Is the creation in a language of a new word, derived or composed with the help of elements already existing in that language, and which is not distinguished in any way by the external aspect of the older words, but which, in fact, is only the copy ( calque ) of a word existing in the mother tongue of the one who tries out a new language. [...] we want to recall only two or three examples of these copies ( calques ) of expressions, among

2784-622: Is very old. Homer used it in the Odyssey to describe the monstrous Scylla , with her mouths "full of black Death" ( Ancient Greek : πλεῖοι μέλανος Θανάτοιο , romanized :  pleîoi mélanos Thanátoio ). Seneca the Younger may have been the first to describe an epidemic as 'black death', ( Latin : mors atra ) but only in reference to the acute lethality and dark prognosis of disease. The 12th–13th century French physician Gilles de Corbeil had already used atra mors to refer to

2900-800: The Trésor de la langue française informatisé , the French term calque has been used in its linguistic sense, namely in a publication by Louis Duvau: Un autre phénomène d'hybridation est la création dans une langue d'un mot nouveau, dérivé ou composé à l'aide d'éléments existant déja dans cette langue, et ne se distinguant en rien par l'aspect extérieur des mots plus anciens, mais qui, en fait, n'est que le calque d'un mot existant dans la langue maternelle de celui qui s'essaye à un parler nouveau. [...] nous voulons rappeler seulement deux ou trois exemples de ces calques d'expressions, parmi les plus certains et les plus frappants. Another phenomenon of hybridization

3016-661: The Golden Horde army of Jani Beg in 1347. From Crimea, it was most likely carried by fleas living on the black rats that travelled on Genoese ships, spreading through the Mediterranean Basin and reaching North Africa , West Asia , and the rest of Europe via Constantinople , Sicily , and the Italian Peninsula . There is evidence that once it came ashore, the Black Death mainly spread from person-to-person as pneumonic plague , thus explaining

3132-507: The Great Plague of London in 1665–66. Later works, such as Albert Camus 's novel The Plague or Ingmar Bergman 's film The Seventh Seal have used bubonic plague in settings, such as quarantined cities in either medieval or modern times, as a backdrop to explore themes including the breakdown of society, institutions, and individuals during the plague; the cultural and psychological existential confrontation with mortality; and

3248-799: The Mamluk Sultanate , cultural center of the Islamic world , and the largest city in the Mediterranean Basin ; the Bahriyya child sultan an-Nasir Hasan fled and more than a third of the 600,000 residents died. The Nile was choked with corpses despite Cairo having a medieval hospital, the late 13th-century bimaristan of the Qalawun complex . The historian al-Maqrizi described the abundant work for grave-diggers and practitioners of funeral rites ; plague recurred in Cairo more than fifty times over

3364-629: The Neolithic , with flea-mediated strains emerging around 3,800 years ago during the late Bronze Age . The immediate territorial origins of the Black Death and its outbreak remain unclear, with some evidence pointing towards Central Asia , China, the Middle East , and Europe. The pandemic was reportedly first introduced to Europe during the siege of the Genoese trading port of Kaffa in Crimea by

3480-616: The Roman Empire before the reign of Trajan , six centuries before arriving at Pelusium in the reign of Justinian I . In 2013, researchers confirmed earlier speculation that the cause of the Plague of Justinian (541–549 CE, with recurrences until 750) was Y . pestis . This is known as the first plague pandemic . In 610, the Chinese physician Chao Yuanfang described a "malignant bubo" "coming in abruptly with high fever together with

3596-488: The Western canon . The Decameron , by Boccaccio, is notable for its use of a frame story involving individuals who have fled Florence for a secluded villa to escape the Black Death. First-person, sometimes sensationalized or fictionalized, accounts of living through plague years have also been popular across centuries and cultures. For example, Samuel Pepys 's diary makes several references to his first-hand experiences of

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3712-490: The World Health Organization recommends that only high-risk groups, such as certain laboratory personnel and health care workers, get inoculated. Several antibiotics are effective for treatment, including streptomycin , gentamicin , and doxycycline . Without treatment, plague results in the death of 30% to 90% of those infected. Death, if it occurs, is typically within 10 days. With treatment,

3828-471: The Y. pestis strain responsible for the Black Death as both the ancestor of later plague epidemics—including the third plague pandemic —and the descendant of the strain responsible for the Plague of Justinian . In addition, plague genomes from prehistory have been recovered. DNA taken from 25 skeletons from 14th-century London showed that plague is a strain of Y. pestis almost identical to that which hit Madagascar in 2013 . Further DNA evidence also proves

3944-620: The Yunnan Province in 1855. The term bubonic is derived from the Greek word βουβών , meaning ' groin ' . The bubonic plague is an infection of the lymphatic system , usually resulting from the bite of an infected flea, Xenopsylla cheopis (the Oriental rat flea ). Several flea species carried the bubonic plague, such as Pulex irritans (the human flea ), Xenopsylla cheopis , and Ceratophyllus fasciatus . Xenopsylla cheopis

4060-516: The besiegers and from them penetrated the town. The Mongol forces catapulted plague-infested corpses into Caffa as a form of attack, one of the first known instances of biological warfare . When spring arrived, the Italian merchants fled on their ships, unknowingly carrying the Black Death. Carried by the fleas on rats, the plague initially spread to humans near the Black Sea and then outwards to

4176-516: The fluoroquinolone ciprofloxacin . Mortality associated with treated cases of bubonic plague is about 1–15%, compared to a mortality of 40–60% in untreated cases. People potentially infected with the plague need immediate treatment and should be given antibiotics within 24 hours of the first symptoms to prevent death. Other treatments include oxygen, intravenous fluids, and respiratory support. People who have had contact with anyone infected by pneumonic plague are given prophylactic antibiotics. Using

4292-438: The gavocciolo had been and still was an infallible token of approaching death, such also were these spots on whomsoever they showed themselves. This was followed by acute fever and vomiting of blood . Most people died two to seven days after initial infection. Freckle-like spots and rashes, which may have been caused by flea-bites , were identified as another potential sign of plague. Bubonic plague Bubonic plague

4408-552: The germ theory of disease . Until then streets were usually unhygienic, with live animals and human parasites facilitating the spread of transmissible disease . By the early 14th century, so much filth had collected inside urban Europe that French and Italian cities were naming streets after human waste. In medieval Paris, several street names were inspired by merde, the French word for "shit". There were rue Merdeux, rue Merdelet, rue Merdusson, rue des Merdons and rue Merdiere—as well as

4524-403: The poll tax of the year 1377. Estimates of plague victims are usually extrapolated from figures for the clergy. Mathematical modelling is used to match the spreading patterns and the means of transmission . In 2018 researchers suggested an alternative model in which "the disease was spread from human fleas and body lice to other people". The second model claims to better fit the trends of

4640-440: The " Neolithic decline " around 3000 BCE, in which European populations fell significantly. This Y. pestis may have been different from more modern types, with bubonic plague transmissible by fleas first known from Bronze Age remains near Samara . The symptoms of bubonic plague are first attested in a fragment of Rufus of Ephesus preserved by Oribasius ; these ancient medical authorities suggest bubonic plague had appeared in

4756-764: The 14th century, as previously speculated. The Black Death was the second great natural disaster to strike Europe during the Late Middle Ages (the first one being the Great Famine of 1315–1317 ) and is estimated to have killed 30% to 60% of the European population, as well as approximately 33% of the population of the Middle East. There were further outbreaks throughout the Late Middle Ages and, also due to other contributing factors (the Crisis of

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4872-482: The 15th and early 16th centuries, and in the 16th and 17th centuries was transferred to other languages as a calque : Icelandic : svarti dauði , German : der schwarze Tod , and French : la mort noire . Previously, most European languages had named the pandemic a variant or calque of the Latin : magna mortalitas , lit.   'Great Death'. The phrase 'black death' – describing Death as black –

4988-455: The 1640s. Nestorian gravesites dating from 1338 to 1339 near Issyk-Kul have inscriptions referring to plague, which has led some historians and epidemiologists to think they mark the outbreak of the epidemic ; this is supported by recent direct findings of Y. pestis DNA in teeth samples from graves in the area with inscriptions referring to "pestilence" as the cause of death. Epidemics killed an estimated 25 million across Asia during

5104-448: The 18th century, the event was called the "pestilence" or "great pestilence", "the plague" or the "great death". Subsequent to the pandemic "the furste moreyn " (first murrain ) or "first pestilence" was applied, to distinguish the mid-14th century phenomenon from other infectious diseases and epidemics of plague. The 1347 pandemic plague was not referred to specifically as "black" in the time of occurrence in any European language, though

5220-553: The 18th century. The disease remained localized in Southwest China for several years before spreading. In the city of Canton , beginning in January 1894, the disease had killed 80,000 people by June. Daily water traffic with the nearby city of Hong Kong rapidly spread the plague there, killing over 2,400 within two months during the 1894 Hong Kong plague . The third pandemic spread the disease to port cities throughout

5336-468: The 8th century. Because the infectious disease spread inland by the transferring of merchandise through Justinian's efforts in acquiring luxurious goods of the time and exporting supplies, his capital became the leading exporter of the bubonic plague. Procopius, in his work Secret History , declared that Justinian was a demon of an emperor who either created the plague himself or was being punished for his sinfulness. Medieval society's increasing population

5452-405: The Black Death had far-reaching population, economic, and cultural impacts. It was the beginning of the second plague pandemic . The plague created religious, social and economic upheavals, with profound effects on the course of European history. The origin of the Black Death is disputed. Genetic analysis suggests Yersinia pestis bacteria evolved approximately 7,000 years ago, at the beginning of

5568-416: The Black Death in 14th century China. As a result, China's place in the sequence of the plague's spread is still debated to this day. According to Charles Creighton, records of epidemics in 14th-century China suggest nothing more than typhus and major Chinese outbreaks of epidemic disease post-date the European epidemic by several years. The earliest Chinese descriptions of the bubonic plague do not appear until

5684-511: The Black Death, because there were actually four strains of Yersinia pestis that became predominant in different parts of the world. Mongol records of illness such as food poisoning may have been referring to the Black Death. Another theory is that the plague originated near Europe and cycled through the Mediterranean, Northern Europe and Russia before making its way to China. Other historians, such as John Norris and Ole Benedictaw, believe

5800-698: The Democratic Republic of the Congo had the most plague cases, with over 1,100 cases in the Democratic Republic of the Congo alone. From 1,000 to 2,000 cases are conservatively reported per year to the WHO . From 2012 to 2017, reflecting political unrest and poor hygienic conditions, Madagascar began to host regular epidemics. Between 1900 and 2015, the United States had 1,036 human plague cases, with an average of 9 cases per year. In 2015, 16 people in

5916-579: The European population. Because the plague killed so many of the working population, wages rose due to the demand for labor. Some historians see this as a turning point in European economic development . The disease is also considered to have been responsible for the Plague of Justinian , originating in the Eastern Roman Empire in the 6th century CE, as well as the third epidemic , affecting China , Mongolia , and India , originating in

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6032-670: The Islamic city of Almería in al-Andalus . Mecca became infected in 1348 by pilgrims performing the Hajj . In 1351 or 1352, the Rasulid sultan of the Yemen , al-Mujahid Ali, was released from Mamluk captivity in Egypt and carried plague with him on his return home. During 1349, records show the city of Mosul suffered a massive epidemic, and the city of Baghdad experienced a second round of

6148-460: The Islamic world in 1347–52. However, there is a conspicuous lack of evidence for pandemic disease on the scale of the Black Death in China at this time. War and famine – and the diseases that typically accompanied them – probably were the main causes of mortality in the final decades of Mongol rule. Monica Green suggests that other parts of Eurasia outside the west do not contain the same evidence of

6264-471: The Late Middle Ages ), the European population did not regain its 14th century level until the 16th century. Outbreaks of the plague recurred around the world until the early 19th century. European writers contemporary with the plague described the disease in Latin as pestis or pestilentia , 'pestilence'; epidemia , 'epidemic'; mortalitas , 'mortality'. In English prior to

6380-619: The Latin translātiō or trādūcō . The Latin weekday names came to be associated by ancient Germanic speakers with their own gods following a practice known as interpretatio germanica : the Latin "Day of Mercury ", Mercurii dies (later mercredi in modern French ), was borrowed into Late Proto-Germanic as the "Day of Wōđanaz " ( Wodanesdag ), which became Wōdnesdæg in Old English , then "Wednesday" in Modern English. Since at least 1894, according to

6496-592: The Silk Road by 1325 and impossible by 1340, making its role in the spread of plague less likely. There are no records of the symptoms of the Black Death from Mongol sources or writings from travelers east of the Black Sea prior to the Crimean outbreak in 1346. Others still favor an origin in China. The theory of Chinese origin implicates the Silk Road, the disease possibly spreading alongside Mongol armies and traders, or possibly arriving via ship—however, this theory

6612-520: The Wars , of his personal encounter with the plague and the effect it had on the rising empire. In the spring of 542, the plague arrived in Constantinople, working its way from port city to port city and spreading around the Mediterranean Sea , later migrating inland eastward into Asia Minor and west into Greece and Italy. The Plague of Justinian is said to have been "completed" in the middle of

6728-532: The animal and the computer mouse. The common English phrase " flea market " is a loan translation of the French marché aux puces ("market with fleas"). At least 22 other languages calque the French expression directly or indirectly through another language. The word loanword is a calque of the German noun Lehnwort . In contrast, the term calque is a loanword, from the French noun calque ("tracing, imitation, close copy"). Another example of

6844-529: The appearance of a bundle of nodes beneath the tissue." The Chinese physician Sun Simo who died in 652 also mentioned a "malignant bubo" and plague that was common in Lingnan ( Guangzhou ). Ole Jørgen Benedictow believes that this indicates it was an offshoot of the first plague pandemic which made its way eastward to Chinese territory by around 600. A report by the Medical Faculty of Paris stated that

6960-414: The approximate sound of the borrowed word by matching it with a similar-sounding pre-existing word or morpheme in the target language. Proving that a word is a calque sometimes requires more documentation than does an untranslated loanword because, in some cases, a similar phrase might have arisen in both languages independently. This is less likely to be the case when the grammar of the proposed calque

7076-402: The bacteria enter through the skin through a flea bite and travel via the lymphatic vessels to a lymph node , causing it to swell. Diagnosis is made by finding the bacteria in the blood, sputum , or fluid from lymph nodes. Prevention is through public health measures such as not handling dead animals in areas where plague is common. While vaccines against the plague have been developed,

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7192-661: The bacterium reproduces in the person's blood and lungs respectively. Laboratory testing is required in order to diagnose and confirm plague. Ideally, confirmation is through the identification of Y. pestis culture from a patient sample. Confirmation of infection can be done by examining serum taken during the early and late stages of infection . To quickly screen for the Y. pestis antigen in patients, rapid dipstick tests have been developed for field use. Samples taken for testing include: Bubonic plague outbreaks are controlled by pest control and modern sanitation techniques. This disease uses fleas commonly found on rats as

7308-401: The bites of fleas whose midguts had become obstructed by replicating Y. pestis several days after feeding on an infected host. This blockage starves the fleas, drives them to aggressive feeding behaviour, and causes them to try to clear the blockage via regurgitation , resulting in thousands of plague bacteria flushing into the feeding site and infecting the host. The bubonic plague mechanism

7424-508: The broad-based antibiotic streptomycin has proven to be dramatically successful against the bubonic plague within 12 hours of infection. Globally between 2010 and 2015, there were 3,248 documented cases, which resulted in 584 deaths. The countries with the greatest number of cases are the Democratic Republic of the Congo , Madagascar , and Peru . For over a decade since 2001, Zambia, India, Malawi, Algeria, China, Peru, and

7540-476: The bubonic infection, others point to additional septicemic and pneumonic forms of plague, which lengthen the duration of outbreaks throughout the seasons and help account for its high mortality rate and additional recorded symptoms. In 2014, Public Health England announced the results of an examination of 25 bodies exhumed in the Clerkenwell area of London, as well as of wills registered in London during

7656-486: The city walls of Kaffa to infect the inhabitants, though it is also likely that infected rats travelled across the siege lines to spread the epidemic to the inhabitants. As the disease took hold, Genoese traders fled across the Black Sea to Constantinople , where the disease first arrived in Europe in summer 1347. The epidemic there killed the 13-year-old son of the Byzantine emperor , John VI Kantakouzenos , who wrote

7772-411: The continent. According to some epidemiologists, periods of unfavorable weather decimated plague-infected rodent populations, forcing their fleas onto alternative hosts, inducing plague outbreaks which often peaked in the hot summers of the Mediterranean and during the cool autumn months of the southern Baltic region . Among many other culprits of plague contagiousness, pre-existing malnutrition weakened

7888-652: The country. Unusually, most of the cases were pneumonic rather than bubonic. In June 2018, a child was confirmed to be the first person in Idaho to be infected by bubonic plague in nearly 30 years. A couple died in May 2019, in Mongolia, while hunting marmots . Another two people in the province of Inner Mongolia, China, were treated in November 2019 for the disease. In July 2020, in Bayannur , Inner Mongolia of China,

8004-512: The death of tissue. Y. pestis bacilli can resist phagocytosis and even reproduce inside phagocytes and kill them. As the disease progresses, the lymph nodes can hemorrhage and become swollen and necrotic . Bubonic plague can progress to lethal septicemic plague in some cases. The plague is also known to spread to the lungs and become the disease known as the pneumonic plague . Symptoms appear two to seven days after getting bitten and they include: The best-known symptom of bubonic plague

8120-597: The debate about the cause of the Black Death, and unambiguously demonstrates that Y. pestis was the causative agent of the epidemic plague that devastated Europe during the Middle Ages". In 2011 these results were further confirmed with genetic evidence derived from Black Death victims in the East Smithfield burial site in England. Schuenemann et al. concluded in 2011 "that the Black Death in medieval Europe

8236-437: The decay or decomposition of the skin while the person is still alive. Additional symptoms include extreme fatigue, gastrointestinal problems, spleen inflammation, lenticulae (black dots scattered throughout the body), delirium, coma , organ failure, and death. Organ failure is a result of the bacteria infecting organs through the bloodstream. Other forms of the disease include septicemic plague and pneumonic plague , in which

8352-628: The disease spread rapidly all over the island. Galleys from Kaffa reached Genoa and Venice in January 1348, but it was the outbreak in Pisa a few weeks later that was the entry point into northern Italy. Towards the end of January, one of the galleys expelled from Italy arrived in Marseilles . From Italy , the disease spread northwest across Europe, striking France , Spain , Portugal, and England by June 1348, then spreading east and north through Germany , Scotland and Scandinavia from 1348 to 1350. It

8468-540: The disease. Symptoms of the plague include fever of 38–41 °C (100–106 °F), headaches, painful aching joints , nausea and vomiting, and a general feeling of malaise . Left untreated, 80% of victims die within eight days. Contemporary accounts of the pandemic are varied and often imprecise. The most commonly noted symptom was the appearance of buboes (or gavocciolos ) in the groin, neck and armpits, which oozed pus and bled when opened. Boccaccio 's description: In men and women alike it first betrayed itself by

8584-466: The emergence of certain tumours in the groin or armpits, some of which grew as large as a common apple, others as an egg ... From the two said parts of the body this deadly gavocciolo soon began to propagate and spread itself in all directions indifferently; after which the form of the malady began to change, black spots or livid making their appearance in many cases on the arm or the thigh or elsewhere, now few and large, now minute and numerous. As

8700-411: The expression "black death" had occasionally been applied to fatal disease beforehand. "Black death" was not used to describe the plague pandemic in English until the 1750s; the term is first attested in 1755, where it translated Danish : den sorte død , lit.   'the black death'. This expression as a proper name for the pandemic had been popularized by Swedish and Danish chroniclers in

8816-486: The fifteen years before the Black Death reached Constantinople in 1347. The evidence does not suggest, at least at present, that these mortality crises were caused by plague. Although some scholars, including McNeill and Cao, see the 1333 outbreak as a prelude to the outbreaks in Europe from the late 1340s to the early 1350s, scholars of the Yuan and Ming periods remain skeptical about such an interpretation. Nonetheless,

8932-461: The first clear reports of the Black Death come from Kaffa , the Black Death most likely originated in the nearby plague focus on the northwestern shore of the Caspian Sea . Demographic historians estimate that China's population fell by at least 15 per cent, and perhaps as much as a third, between 1340 and 1370. This population loss coincided with the Black Death that ravaged Europe and much of

9048-489: The following one and a half centuries. During 1347, the disease travelled eastward to Gaza by April; by July it had reached Damascus , and in October plague had broken out in Aleppo . That year, in the territory of modern Lebanon , Syria , Israel , and Palestine , the cities of Ascalon , Acre , Jerusalem , Sidon , and Homs were all infected. In 1348–1349, the disease reached Antioch . The city's residents fled to

9164-411: The gut of infected fleas, and this results in the flea regurgitating ingested blood, which is now infected, into the bite site of a rodent or human host. Once established, the bacteria rapidly spread to the lymph nodes of the host and multiply. The fleas that transmit the disease only directly infect humans when the rat population in the area is wiped out from a mass infection. Furthermore, in areas with

9280-466: The immune response, contributing to an immense decline in European population. The disease struck various regions in the Middle East and North Africa during the pandemic , leading to serious depopulation and permanent change in both economic and social structures. By autumn 1347, plague had reached Alexandria in Egypt, transmitted by sea from Constantinople via a single merchant ship carrying slaves. By late summer 1348, it reached Cairo , capital of

9396-533: The latter's description was imprecise and also expressed doubts of its relation to the disease, and thus the bacterium is today only named after Yersin. The scale of death and social upheaval associated with plague outbreaks has made the topic prominent in many historical and fictional accounts since the disease was first recognized. The Black Death in particular is described and referenced in numerous contemporary sources , some of which, including works by Chaucer , Boccaccio , and Petrarch , are considered part of

9512-575: The mass mortality rate cheapened life and thus increased warfare, crime, popular revolt, waves of flagellants , and persecution. The Black Death originated in Central Asia and spread from Italy and then throughout other European countries. Arab historians Ibn Al-Wardni and Almaqrizi believed the Black Death originated in Mongolia. Chinese records also show a huge outbreak in Mongolia in the early 1330s. In 2022, researchers presented evidence that

9628-582: The north, but most of them ended up dying during the journey. Within two years, the plague had spread throughout the Islamic world, from Arabia across North Africa. The pandemic spread westwards from Alexandria along the African coast, while in April 1348 Tunis was infected by ship from Sicily. Tunis was then under attack by an army from Morocco; this army dispersed in 1348 and brought the contagion with them to Morocco, whose epidemic may also have been seeded from

9744-550: The origin of the plague and how it traveled through the continent. Mitochondrial DNA of modern rats in Western Europe indicated that these rats came from two different areas, one being Africa and the other unclear. The research regarding this pandemic has greatly increased with technology. Through archaeo-molecular investigation, researchers have discovered the DNA of plague bacillus in the dental core of those that fell ill to

9860-562: The people that scarce the tenth person of any sort was left alive. Geoffrey the Baker , Chronicon Angliae Plague was reportedly first introduced to Europe via Genoese traders from their port city of Kaffa in the Crimea in 1347. During a protracted siege of the city in 1345–1346, the Mongol Golden Horde army of Jani Beg —whose mainly Tatar troops were suffering from the disease— catapulted infected corpses over

9976-406: The period, which supported the pneumonic hypothesis. Currently, while osteoarcheologists have conclusively verified the presence of Y. pestis bacteria in burial sites across northern Europe through examination of bones and dental pulp , no other epidemic pathogen has been discovered to bolster the alternative explanations. The importance of hygiene was not recognized until the 19th century and

10092-474: The phrase is not connected unambiguously with the plague pandemic of 1347 and appears to refer to the fatal outcome of disease. The historian Cardinal Francis Aidan Gasquet wrote about the Great Pestilence in 1893 and suggested that it had been "some form of the ordinary Eastern or bubonic plague". In 1908, Gasquet said use of the name atra mors for the 14th-century epidemic first appeared in

10208-406: The plague as an allegory raising contemporary moral or spiritual questions. Some of the earliest instances of biological warfare were said to have been products of the plague, as armies of the 14th century were recorded catapulting diseased corpses over the walls of towns and villages to spread the pestilence. This was done by Jani Beg when he attacked the city of Kaffa in 1343. Later, plague

10324-666: The plague likely originated in Europe or the Middle East, and never reached China. Norris specifically argues for an origin in Kurdistan rather than Central Asia. The seventh year after it began, it came to England and first began in the towns and ports joining on the seacoasts, in Dorsetshire , where, as in other counties, it made the country quite void of inhabitants so that there were almost none left alive. ... But at length it came to Gloucester , yea even to Oxford and to London, and finally it spread over all England and so wasted

10440-507: The plague originated near Lake Issyk-Kul in Kyrgyzstan . The Mongols had cut the trade route (the Silk Road ) between China and Europe, which halted the spread of the Black Death from eastern Russia to Western Europe. The European epidemic may have begun with the siege of Caffa , an attack that Mongols launched on the Italian merchants' last trading station in the region, Caffa , in the Crimea . In late 1346, plague broke out among

10556-656: The plague was responsible for the Neolithic decline . The first recorded epidemic affected the Sasanian Empire and their arch-rivals, the Eastern Roman Empire (Byzantine Empire) and was named the Plague of Justinian (541–549 AD) after emperor Justinian I , who was infected but survived through extensive treatment. The pandemic resulted in the deaths of an estimated 25 million (6th century outbreak) to 50 million people (two centuries of recurrence). The historian Procopius wrote, in Volume II of History of

10672-475: The plague's death toll, as the rat-flea-human hypothesis would have produced a delayed but very high spike in deaths, contradicting historical death data. Lars Walløe argued that these authors "take it for granted that Simond's infection model, black rat → rat flea → human, which was developed to explain the spread of plague in India, is the only way an epidemic of Yersinia pestis infection could spread". Similarly, Monica Green has argued that greater attention

10788-483: The plague. Analysis of teeth of the deceased allows researchers to further understand both the demographics and mortuary patterns of the disease. For example, in 2013 in England, archeologists uncovered a burial mound to reveal 17 bodies, mainly children, who had died of the Bubonic plague. They analyzed these burial remains using radiocarbon dating to determine they were from the 1530s, and dental core analysis revealed

10904-401: The presence of DNA / RNA with polymerase chain reaction (PCR) techniques for Y. pestis from the tooth sockets in human skeletons from mass graves in northern, central and southern Europe that were associated archaeologically with the Black Death and subsequent resurgences. The authors concluded that this new research, together with prior analyses from the south of France and Germany, "ends

11020-515: The presence of Yersinia pestis. Other evidence for rats that are currently still being researched consists of gnaw marks on bones, predator pellets and rat remains that were preserved in situ . This research allows individuals to trace early rat remains to track the path traveled and in turn connect the impact of the Bubonic Plague to specific breeds of rats. Burial sites, known as plague pits, offer archaeologists an opportunity to study

11136-400: The quick inland spread of the epidemic, which was faster than would be expected if the primary vector was rat fleas causing bubonic plague. In 2022, it was discovered that there was a sudden surge of deaths in what is today Kyrgyzstan from the Black Death in the late 1330s; when combined with genetic evidence, this implies that the initial spread may not have been due to Mongol conquests in

11252-504: The remains of people who died from the plague. Another research study indicates that these separate pandemics were all interconnected. A current computer model indicates that the disease did not go away in between these pandemics. It rather lurked within the rat population for years without causing human epidemics. Calque Calquing is distinct from phono-semantic matching : while calquing includes semantic translation, it does not consist of phonetic matching—i.e., of retaining

11368-614: The remarkably high mortality rates during the Datong mortality should discourage us from rejecting the possibility of localized/regional outbreaks of plague in different parts of China, albeit differing in scale from, and unrelated to, the pandemic mortality of the Black Death. What we lack is any indication of a plague pandemic that engulfed vast territories of the Yuan Empire and later moved into western Eurasia through Central Asia. According to John Norris, evidence from Issyk-Kul indicates

11484-481: The rest of Europe as a result of people fleeing from one area to another. Rats migrated with humans, traveling among grain bags, clothing, ships, wagons, and grain husks. Continued research indicates that black rats , those that primarily transmitted the disease, prefer grain as a primary meal. Due to this, the major bulk grain fleets that transported major city's food shipments from Africa and Alexandria to heavily populated areas, and were then unloaded by hand, played

11600-425: The result of the route of infection: bubonic plague, septicemic plague , and pneumonic plague . Bubonic plague is mainly spread by infected fleas from small animals . It may also result from exposure to the body fluids from a dead plague-infected animal. Mammals such as rabbits , hares , and some cat species are susceptible to bubonic plague, and typically die upon contraction. In the bubonic form of plague,

11716-514: The risk of death is around 10%. Globally between 2010 and 2015 there were 3,248 documented cases, which resulted in 584 deaths. The countries with the greatest number of cases are the Democratic Republic of the Congo , Madagascar , and Peru . The plague is considered the likely cause of the Black Death that swept through Asia, Europe, and Africa in the 14th century and killed an estimated 50 million people, including about 25% to 60% of

11832-486: The role of Y. pestis and traces the source to the Tian Shan mountains in Kyrgyzstan . Researchers are hampered by a lack of reliable statistics from this period. Most work has been done on the spread of the disease in England, where estimates of overall population at the start of the plague vary by over 100%, as no census was undertaken in England between the time of publication of the Domesday Book of 1086 and

11948-420: The runoff from the local slaughterhouse had made his garden "stinking and putrid", while another charged that the blood from slain animals flooded nearby streets and lanes, "making a foul corruption and abominable sight to all dwelling near." In much of medieval Europe, sanitation legislation consisted of an ordinance requiring homeowners to shout, "Look out below!" three times before dumping a full chamber pot into

12064-430: The street. Early Christians considered bathing a temptation. With this danger in mind, St. Benedict declared, "To those who are well, and especially to the young, bathing shall seldom be permitted." St. Agnes took the injunction to heart and died without ever bathing. According to a team of medical geneticists led by Mark Achtman , Yersinia pestis "evolved in or near China" over 2,600 years ago. Later research by

12180-606: The western United States developed plague, including 2 cases in Yosemite National Park . These US cases usually occur in rural northern New Mexico, northern Arizona, southern Colorado, California, southern Oregon, and far western Nevada. In November 2017, the Madagascar Ministry of Health reported an outbreak to the WHO (World Health Organization) with more cases and deaths than any recent outbreak in

12296-471: The western United States. Y. pestis was discovered by Alexandre Yersin , a pupil of Louis Pasteur , during an epidemic of bubonic plague in Hong Kong in 1894; Yersin also proved this bacterium was present in rodents and suggested the rat was the main vehicle of transmission. The mechanism by which Y. pestis is usually transmitted was established in 1898 by Paul-Louis Simond and was found to involve

12412-688: The world in the second half of the 19th century and the early 20th century via shipping routes. The plague infected people in Chinatown in San Francisco from 1900 to 1904, and in the nearby locales of Oakland and the East Bay again from 1907 to 1909. During the former outbreak, in 1902, authorities made permanent the Chinese Exclusion Act , a law originally signed into existence by President Chester A. Arthur in 1882. The Act

12528-487: The writings of the ancient Greeks. Due to climate change in Asia , rodents began to flee the dried-out grasslands to more populated areas, spreading the disease. The plague disease, caused by the bacterium Yersinia pestis , is enzootic (commonly present) in populations of fleas carried by ground rodents , including marmots , in various areas, including Central Asia , Kurdistan , West Asia , North India , Uganda , and

12644-491: Was also dependent on two populations of rodents: one resistant to the disease, which act as hosts , keeping the disease endemic , and a second that lacks resistance. When the second population dies, the fleas move on to other hosts, including people, thus creating a human epidemic . Definitive confirmation of the role of Y. pestis arrived in 2010 with a publication in PLOS Pathogens by Haensch et al. They assessed

12760-454: Was caused by a variant of Y. pestis that may no longer exist". Later in 2011, Bos et al. reported in Nature the first draft genome of Y. pestis from plague victims from the same East Smithfield cemetery and indicated that the strain that caused the Black Death is ancestral to most modern strains of Y. pestis . Later genomic papers have further confirmed the phylogenetic placement of

12876-529: Was introduced into Norway in 1349 when a ship landed at Askøy , then spread to Bjørgvin (modern Bergen ). Finally, it spread to northern Russia in 1352 and reached Moscow in 1353. Plague was less common in parts of Europe with less-established trade relations, including the majority of the Basque Country , isolated parts of Belgium and the Netherlands , and isolated Alpine villages throughout

12992-514: Was named in English for its resemblance to the animal . Many other languages use their word for "mouse" for the "computer mouse", sometimes using a diminutive or, in Chinese , adding the word " cursor " ( 标 ), making shǔbiāo "mouse cursor" ( simplified Chinese : 鼠标 ; traditional Chinese : 鼠標 ; pinyin : shǔbiāo ). Another example is the Spanish word ratón that means both

13108-505: Was put to deadly halt when, in the Late Middle Ages , Europe experienced the deadliest disease outbreak in history. They called it the Great Dying or The Great Pestilence, later coined The Black Death. Lasting in potency for roughly six years, 1346–1352, the Black Death claimed one-third of the European human population, with mortality rates as high as 70%–80%. Some historians believe that society subsequently became more violent as

13224-576: Was supposed to last for 10 years, but was renewed in 1892 with the Geary Act , then followed by the 1902 decision. The last major outbreak in the United States occurred in Los Angeles in 1924, though the disease is still present in wild rodents and can be passed to humans who come in contact with them. According to the World Health Organization , the pandemic was considered active until 1959, when worldwide casualties dropped to 200 per year. In 1994,

13340-402: Was the most effective flea species for transmission. The flea is parasitic on house and field rats and seeks out other prey when its rodent host dies. Rats were an amplifying factor to bubonic plague due to their common association with humans as well as the nature of their blood. The rat's blood allows the rat to withstand a major concentration of the plague. The bacteria form aggregates in

13456-969: Was used during the Second Sino-Japanese War as a bacteriological weapon by the Imperial Japanese Army . These weapons were provided by Shirō Ishii 's units and used in experiments on humans before being used in the field. For example, in 1940, the Imperial Japanese Army Air Service bombed Ningbo with fleas carrying the bubonic plague. During the Khabarovsk War Crime Trials , the accused, such as Major General Kiyoshi Kawashima, testified that, in 1941, 40 members of Unit 731 air-dropped plague -contaminated fleas on Changde . These operations caused epidemic plague outbreaks. Substantial research has been done regarding

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