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27-489: (Redirected from Da ) [REDACTED] Look up da , Da , DA , or Appendix:Variations of "da" in Wiktionary, the free dictionary. Da , DA , dA , DÄ and other variants may refer to: Arts, entertainment, and media [ edit ] DA! (band) , a Chicago post-punk band of the 1980s Da (play) , a 1978 play by Hugh Leonard Da (film) ,

54-636: A tricarboxylic acid (TCA) cycle intermediate. In 2018, using growth conditions known to induce domoic acid production in Pseudo-nitzschia multiseries , transcriptome sequencing successfully identified candidate domoic acid biosynthesis genes responsible for the pyrrolidine core. These domoic acid biosynthesis genes, or ‘Dab’ enzymes were heterologously expressed, characterized, and annotated as dabA (terpene cyclase), dabB (hypothetical protein), dabC (α-ketoglutarate–dependent dioxygenase), and dabD (CYP450). Domoic acid biosynthesis begins with

81-555: A 1988 film based on the play Damon Amendolara , American sports talk radio host Daniel Amos , also known as D.A. and Dä, an American Christian rock band Dennis Armand Lucchesi, who recorded the song " Ready 'n' Steady " under the name "D.A." Destination America , television channel DeviantArt or DA, a website that focuses on art Dumbledore's Army , a group formed by Harry Potter in his 5th year to teach students defensive spells Jon Moxley , formerly Dean Ambrose in WWE,

108-463: A cutting utensil also known as daa Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title DA . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=DA&oldid=1255145918 " Category : Disambiguation pages Hidden categories: Short description

135-510: A defunct Israeli political party Defence Advisory Notice , a government demand in Australia and the UK not to publish or broadcast a specified news item Democratic Alliance (South Africa) , a South African political party Democratic Awakening , East German political party Department of Agriculture (Philippines) , an executive department Deutsche Alternative ("German Alternative"),

162-648: A rightist group District attorney , (United States) chief prosecutor for a local government area, particularly a county Dreptate şi Adevăr a defunct alliance of parties in Romania Places [ edit ] Da County , a division in Sichuan, China DA postcode area , a postcode area in England Da River or Black River, a river in China and northwestern Vietnam Dah, Ivory Coast ,

189-593: A species of red algae, Chondria armata , in Japan, which is commonly referred to as dōmoi (ドウモイ) in the Tokunoshima dialect, or hanayanagi . Poisonings in history have been rare, or undocumented; however, it is thought that the increase in human activities is resulting in an increasing frequency of harmful algal blooms along coastlines in recent years. In 2015, the North American Pacific coast

216-717: A syllable in Javanese script Da. or Dòna, the honorific Mrs. in Occitan language Da Hoss , an American racehorse Dame of St Andrew , a discontinued award within the Order of Barbados Danish language (ISO 639-1 alpha-2 code DA) Dearness allowance , cost of living allowance to government employees in Bangladesh, India, and Pakistan Desk accessory , graphical programs Direct action (military) , in special operations Disadvantage , an off-case argument used by

243-609: A village in Montagnes District, Ivory Coast, also spelt "Da" Science and technology [ edit ] Biology and medicine [ edit ] DA (chemotherapy) , standard-dose cytarabine plus daunorubicin Deoxyanthocyanidin Domoic acid , a neurotoxin produced by phytoplankton Donor-Acceptor Dopamine , a monoamine neurotransmitter Other uses in science and technology [ edit ] Dalton (unit) (symbol Da), also called

270-502: A wrestler Degrees and licenses [ edit ] Diploma of Anesthesiology, a degree conferred by some medical institutions such as the Royal College of Anaesthetists Doctor of Arts , an academic degree Organizations [ edit ] Da! , a Russian youth movement Debtors Anonymous Air Georgia , a Georgian airline (IATA code DA) Politics and judiciary [ edit ] Da (political party) ,

297-401: Is a heat-resistant and very stable toxin, which can damage kidneys at concentrations that are 100 times lower than what causes neurological effects. In order to be diagnosed and treated if poisoned, domoic acid must first be detected. Methods such as ELISA or probe development with polymerase chain reaction (PCR) may be used to detect the toxin or the organism producing this toxin. There

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324-523: Is different from Wikidata All article disambiguation pages All disambiguation pages da">da The requested page title contains unsupported characters : ">". Return to Main Page . Domoic acid There has been little use of domoic acid throughout history except for in Japan , where it has been used as an anthelmintic for centuries. Domoic acid was first isolated in 1959 from

351-603: Is important to pay attention to environmental condition factors. On August 18, 1961, in Capitola and Santa Cruz, California there was an invasion of what people described as chaotic seabirds. These birds were believed to be under the influence of domoic acid, and it inspired a scene in Alfred Hitchcock 's feature film The Birds . In the Elementary Season 1 Episode 13 "The Red Team", domoic acid

378-442: Is needed to resolve the final isomerization reaction to complete the pathway to Domoic acid. Using intermediates 5 and 6, a Diels-Alder reaction produced a bicyclic compound (7). 7 then underwent ozonolysis to open the six-membered ring leading to selenide (8). 8 was then deselenated to form 9 (E-9 and Z-9), lastly leading to the formation of (-) domoic acid. The effects of domoic acid have been attributed to several mechanisms, but

405-477: Is no known antidote available for domoic acid. Therefore, if poisoning occurs, it is advised to go quickly to a hospital. Cooking or freezing affected fish or shellfish tissue that are contaminated with domoic acid does not lessen the toxicity. As a public health concern, the concentration of domoic acid in shellfish and shellfish parts at point of sale should not exceed the current permissible limit of 20 mg/kg tissue. In addition, during processing shellfish, it

432-444: Is normal, the uncontrolled increase of calcium causes the cells to degenerate. Because the hippocampus may be severely damaged, short-term memory loss occurs. It may also cause kidney damage – even at levels considered safe for human consumption, a new study in mice has revealed. The kidney is affected at a hundred times lower than the concentration allowed under FDA regulations. Domoic acid producing algal blooms are associated with

459-467: The 1987 domoic acid poisoning on Prince Edward Island concentrations ranging from 0.31 to 1.28 mg/kg of muscle tissue were noted in people that became ill (three of whom died). Dangerous levels of domoic acid have been calculated based on cases such as the one on Prince Edward island. The exact LD 50 for humans is unknown; for mice the LD 50 is 3.6 mg/kg. New research has found that domoic acid

486-503: The DabA-catalyzed geranylation of L-glutamic acid (L-Glu) with geranyl pyrophosphate (GPP) to form N-geranyl -L-glutamic acid (L-NGG). DabD then performs three successive oxidation reactions at the 7′-methyl of L-NGG to produce 7′-carboxy-L-NGG, which is then cyclized by DabC to generate the naturally occurring isodomoic acid A. Finally, an uncharacterized isomerase could convert isodomoic acid A to domoic acid. Further investigation

513-530: The Negative team in a policy debate Doomsday argument , a probabilistic argument based on demographics predicting how many people will be born Duck's ass or duck's arse, a haircut; particularly popular during the 1950s Dynamic game difficulty balancing , also known as difficulty adjustment or DA, an algorithm in video games. See also [ edit ] Da Da Da (disambiguation) Dah (disambiguation) The D.A. (disambiguation) Boti ,

540-415: The channel from rapid desensitization. In addition there is a synergistic effect with endogenous glutamate and N-Methyl-D-aspartate receptor agonists that contribute to the excitotoxicity. In the brain, domoic acid especially damages the hippocampus and amygdaloid nucleus. It damages the neurons by activating AMPA and kainate receptors , causing an influx of calcium. Although calcium flowing into cells

567-534: The first and only to synthesize domoic acid in 1982. In 1999, using C - and C -labelled precursors, the biosynthesis of domoic acid in the diatom genus Pseudo-nitzschia was examined. After addition of [1,2-13C2]-acetate, NMR spectroscopy showed enrichment of every carbon in domoic acid, indicating incorporation of the carbon isotopes. This enrichment was consistent with two biosynthetic pathways. The labeling pattern determined that domoic acid can be biosynthesized by an isoprenoid intermediate in combination with

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594-414: The one of concern is through glutamate receptors . Domoic acid is an excitatory amino acid analogue of glutamate; a neurotransmitter in the brain that activates glutamate receptors. Domoic acid has a very strong affinity for these receptors, which results in excitotoxicity initiated by an integrative action on ionotropic glutamate receptors at both sides of the synapse, coupled with the effect of blocking

621-715: The phenomenon of amnesic shellfish poisoning (ASP). Domoic acid can bioaccumulate in marine organisms such as shellfish, anchovies, and sardines that feed on the phytoplankton known to produce this toxin. It can accumulate in high concentrations in the tissues of these plankton feeders when the toxic phytoplankton are high in concentration in the surrounding waters. Domoic acid is a neurotoxin that inhibits neurochemical processes, causing short-term memory loss, brain damage, and, in severe cases, death in humans. In marine mammals, domoic acid typically causes seizures and tremors. Studies have shown that there are no symptomatic effects in humans at levels of 0.5 mg/kg of body weight. In

648-749: The unified atomic mass unit Deca- or da-, an SI prefix for a factor of 10 Distribution amplifier , a device that accepts a single input signal and provides this same signal to multiple isolated outputs Double-action , a firearm operation mechanism in which the trigger both cocks and releases the hammer NZR DA class , a New Zealand diesel locomotive SJ Da , a Swedish electric locomotive Domain authority Domain Authority Sports [ edit ] U.S. Soccer Development Academy , former United States soccer league Other uses [ edit ] D.A. Wallach (born 1985), American musician and business executive Da (Javanese) ,

675-650: The windshield of a car on the Pacific Coast Highway . On Friday, June 14, 2019, a teenager was attacked and injured by a sea lion that was alleged to be under the influence of domoic acid in Pismo Beach on the Central California coast. Domoic acid is a structural analog of kainic acid , proline , and endogenous excitatory neurotransmitter glutamate . Ohfune and Tomita, who wanted to investigate its absolute stereochemistry, were

702-479: Was heavily impacted by an algal bloom, consisting predominantly of the domoic acid-producing pennate diatom, Pseudo-nitzschia . Consequently, elevated levels of domoic acid were measured in stranded marine mammals, prompting the closure of beaches and damaging razor clam, rock crab and Dungeness crab fisheries. In 1961, seabirds attacked the Capitola area in California , and though it was never confirmed, it

729-476: Was later hypothesized that they were under the influence of domoic acid. In 1987, in Prince Edward Island , Canada, there was a shellfish poisoning resulting in 3 deaths. Blue mussels ( Mytulis edulis ) contaminated with domoic acid were blamed. Domoic acid has been suggested to have been involved in an incident which took place on June 22, 2006, when a California brown pelican flew through

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