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148-605: Established in 1937 in memory of professor Léon Bérard (1876–1960), one of the founders of the League of Nations , to celebrate outstanding service in the field of social medicine . The prize is awarded when there is enough funding, consisting of a bronze medal and a sum of 2500 CHF to be awarded to a person who has accomplished it. Established in 1980 by professor İhsan Doğramacı (1915–2010) to celebrate paediatricians and child health specialists who have given distinguished service in this field every two years. The prize consists of

296-515: A League of Nations mandate ) and the Soviet Union on 18 September 1934, but the Empire of Japan and Germany (under Hitler) withdrew in 1933. This marked the League's largest extent at 58 member states. In December 1920, Argentina quit (being absent from all sessions and votes) without formally withdrawing, on rejection of an Argentine resolution that all sovereign states would be admitted to

444-471: A "permanent league of neutral nations" to work for peace and disarmament. Within months, a call was made for an international women's conference to be held in The Hague . Coordinated by Mia Boissevain , Aletta Jacobs and Rosa Manus , the congress, which opened on 28 April 1915 was attended by 1,136 participants from neutral nations, and resulted in the establishment of an organisation which would become

592-578: A League with the reservation that only Congress could take the U.S. into war. Lodge gained a majority of Senators and Wilson refused to allow a compromise. The Senate voted on the ratification on 19 March 1920, and the 49–35 vote fell short of the needed 2/3 majority . The League held its first council meeting in Paris on 16 January 1920, six days after the Versailles Treaty and the Covenant of

740-575: A blood meal from a previously Plasmodium infected person or animal. Parasites are then typically introduced by the bite of an infected Anopheles mosquito. Some of these inoculated parasites, called " sporozoites ", probably remain in the skin, but others travel in the bloodstream to the liver , where they invade hepatocytes . They grow and divide in the liver for 2–10 days, with each infected hepatocyte eventually harboring up to 40,000 parasites. The infected hepatocytes break down, releasing these invasive Plasmodium cells, called " merozoites ", into

888-644: A body. In the midst of the War, Wilson refused. In 1915, a body similar to the Bryce Group was set up in the United States, led by former president William Howard Taft . It was called the League to Enforce Peace . It advocated the use of arbitration in conflict resolution and the imposition of sanctions on aggressive countries. None of these early organisations envisioned a continuously functioning body; with

1036-440: A certificate of achievement, a plaque from the organization's founder, and an amount of money that cannot exceed US$ 40,000. Established in 2008 in memory of Lee Jong-wook (1945–2006) to celebrate outstanding contributions to public health that went beyond the call of normal duties. The prize consists of a plaque and a sum of money which will not exceed US$ 100,000. The award, which embraces Nelson Mandela 's (1918–2013) humility,

1184-494: A certified award, a plaque, and up to US$ 40,000. The prize can be awarded to more than one person or institution that has made an outstanding contribution to health development. His Highness Sheikh Sabah Al-Ahmad Al-Jaber Al-Sabah (1929–2020) Prize is awarded for research in health care for the elderly and health promotion by the State of Kuwait Health Promotion Foundation to the individual(s) or institution(s). The prize consists of

1332-462: A child under five died of malaria in 2021, and "many of these deaths are preventable and treatable". Malaria is commonly associated with poverty and has a significant negative effect on economic development. In Africa, it is estimated to result in losses of US$ 12 billion a year due to increased healthcare costs, lost ability to work, and adverse effects on tourism. The term malaria originates from Medieval Italian : mala aria 'bad air',

1480-421: A condition of durable peace, "behind international law, and behind all treaty arrangements for preventing or limiting hostilities, some form of international sanction should be devised which would give pause to the hardiest aggressor." The war had had a profound impact, affecting the social, political and economic systems of Europe and inflicting psychological and physical damage. Several empires collapsed: first

1628-414: A consistent supply of microscopy slides and stains. In places where microscopy is unavailable, malaria is diagnosed with RDTs, rapid antigen tests that detect parasite proteins in a fingerstick blood sample. A variety of RDTs are commercially available, targeting the parasite proteins histidine rich protein 2 (HRP2, detects P. falciparum only), lactate dehydrogenase , or aldolase . The HRP2 test

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1776-618: A gold-plated silver medal, a certificate, and an honorarium for services in the field of family health. On the idea and with financial support from Mr Ryōichi Sasakawa (1899–1995), Chairman of the Japan Shipbuilding Industry Foundation and President of the Sasakawa Memorial Health Foundation, the award was founded in 1984. The Sasakawa Health Prize consists of a statuette and money of the order of US$ 30,000 to be given to

1924-407: A good choice for the nations of the world. Support for Geneva as the selection came from Swiss Federal Councillor Gustave Ador and economist William Rappard. The Palais Wilson on Geneva's western lakeshore, named after Woodrow Wilson, was the League's first permanent home. The covenant had ambiguities, as Carole Fink points out. There was not a good fit between Wilson's "revolutionary conception of

2072-472: A greater likelihood of complications and death. Malaria infection affects the immune responses following vaccination for various diseases. For example, malaria suppresses immune responses to polysaccharide vaccines. A potential solution is to give curative treatment before vaccination in areas where malaria is present. Due to the non-specific nature of malaria symptoms, diagnosis is typically suspected based on symptoms and travel history, then confirmed with

2220-456: A laboratory test showing hemoglobin levels below 8 grams per deciliter of blood. In areas of the world with little to no malaria, the WHO recommends only testing people with possible exposure to malaria (typically travel to a malaria-endemic area) and unexplained fever. In sub-Saharan Africa, testing is low, with only about one in four (28%) of children with a fever receiving medical advice or

2368-488: A laboratory test to detect the presence of the parasite in the blood (parasitological test). In areas where malaria is common, the World Health Organization (WHO) recommends clinicians suspect malaria in any person who reports having fevers, or who has a current temperature above 37.5 °C without any other obvious cause. Malaria should be suspected in children with signs of anemia : pale palms or

2516-534: A large amount of sweat on the surface of the skin. Due to the high levels of lactic acid released from the human body, it has been hypothesized to represent a specific human host-recognition cue for anthropophilic (attracted to humans) mosquitoes. Pungent foot odor Most studies use human odors as stimuli to attract host seeking mosquitoes and have reported a strong and significant attractive effect. The studies have found human odor samples very effective in attracting mosquitoes. Foot odors have been demonstrated to have

2664-636: A less pronounced and almost continuous fever. Symptoms typically begin 10–15 days after the initial mosquito bite, but can occur as late as several months after infection with some P. vivax strains. Travellers taking preventative malaria medications may develop symptoms once they stop taking the drugs. Severe malaria is usually caused by P. falciparum (often referred to as falciparum malaria). Symptoms of falciparum malaria arise 9–30 days after infection. Individuals with cerebral malaria frequently exhibit neurological symptoms, including abnormal posturing , nystagmus , conjugate gaze palsy (failure of

2812-435: A non-invasive way to detect malarial infections. In addition, these volatile compounds were heavily detected by mosquito antennae as an attractant, making the children more vulnerable to the bite of the mosquitos. Fatty acids Fatty acids have been identified as an attractive compound for mosquitoes, they are typically found in volatile emissions from the skin. These fatty acids that produce body odor profiles originate from

2960-564: A part of miasma theory ; the disease was formerly called ague or marsh fever due to its association with swamps and marshland. The term appeared in English at least as early as 1768. Malaria was once common in most of Europe and North America, where it is no longer endemic, though imported cases do occur. The scientific study of malaria is called malariology. Adults with malaria tend to experience chills and fever—classically in periodic intense bouts lasting around six hours, followed by

3108-530: A period of sweating and fever relief—as well as headache, fatigue, abdominal discomfort, and muscle pain . Children tend to have more general symptoms: fever, cough, vomiting, and diarrhea. Initial manifestations of the disease—common to all malaria species—are similar to flu-like symptoms , and can resemble other conditions such as sepsis , gastroenteritis , and viral diseases . The presentation may include headache , fever , shivering , joint pain , vomiting , hemolytic anemia , jaundice , hemoglobin in

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3256-507: A person(s) and/or of the order of US$ 40,000 to be given to an institution(s), who have accomplished outstanding innovative work in health development, such as the promotion of specific health programmes or significant advancements in primary health care, to encourage the further development of health. The prize was established in 1993 under the directive of HM Sheikh Zayed Bin Sultan Al Nahayyan (1918–2004). The prize consists of

3404-575: A postdoctoral scholar at the University of California, Berkeley studying the structural basis of membrane manipulation and cell-cell fusion by bacterial pathogens, discusses studies that determine how odor profiles can be used to diagnose the disease. Within the study, samples of volatile compounds from around 400 children within schools in Western Kenya were collected - to identify asymptomatic infections. These biomarkers have been established as

3552-399: A pressure group within the then-governing Liberal Party . In Dickinson's 1915 pamphlet After the War he wrote of his "League of Peace" as being essentially an organisation for arbitration and conciliation. He felt that the secret diplomacy of the early twentieth century had brought about war, and thus, could write that, "the impossibility of war, I believe, would be increased in proportion as

3700-635: A rapid diagnostic test in 2021. There was a 10-percentage point gap in testing between the richest and the poorest children (33% vs 23%). Additionally, a greater proportion of children in Eastern and Southern Africa (36%) were tested than in West and Central Africa (21%). According to UNICEF, 61% of children with a fever were taken for advice or treatment from a health facility or provider in 2021. Disparities are also observed by wealth, with an 18 percentage point difference in care-seeking behaviour between children in

3848-466: A short time, and a "thin film" of blood, allowing them to clearly see individual parasites and identify the infecting Plasmodium species. Under typical field laboratory conditions, a microscopist can detect parasites when there are at least 100 parasites per microliter of blood, which is around the lower range of symptomatic infection. Microscopic diagnosis is relatively resource intensive, requiring trained personnel, specific equipment, electricity, and

3996-595: A small proportion of public expenditure on health. In contrast, a similar programme in Tanzania would cost an estimated one-fifth of the public health budget. In 2021, the World Health Organization confirmed that China has eliminated malaria. In 2023, the World Health Organization confirmed that Azerbaijan , Tajikistan , and Belize have eliminated malaria. In areas where malaria is common, children under five years old often have anaemia , which

4144-541: A study expedition for the League of Nations ' Malaria Commission. In 1948, WHO acquired control of the foundation. A bronze medal and a fixed amount of 2500 CHF make up the Darling Foundation Prize, which is given for exceptional work in the pathology, aetiology, epidemiology, treatment, prevention, or control of malaria. It was discontinued in 2000. The foundation was founded in 1969 by Mrs Parisot in honour of professor Jacques Parisot (1882–1967), who

4292-518: A way past the net. Insecticide-treated nets (ITNs) are estimated to be twice as effective as untreated nets and offer greater than 70% protection compared with no net. Between 2000 and 2008, the use of ITNs saved the lives of an estimated 250,000 infants in Sub-Saharan Africa. According to UNICEF, only 36% of households had sufficient ITNs for all household members in 2019. In 2000, 1.7 million (1.8%) African children living in areas of

4440-797: A year in September. The special functions of the Assembly included the admission of new members, the periodical election of non-permanent members to the council, the election with the Council of the judges of the Permanent Court, and control of the budget. In practice, the Assembly was the general directing force of League activities. The Council acted as a type of executive body directing the Assembly's business. It began with four permanent members – Great Britain , France , Italy , and Japan – and four non-permanent members that were elected by

4588-479: Is a feature of blackwater fever , where haemoglobin from lysed red blood cells leaks into the urine. Infection with P. falciparum may result in cerebral malaria, a form of severe malaria that involves encephalopathy . It is associated with retinal whitening, which may be a useful clinical sign in distinguishing malaria from other causes of fever. An enlarged spleen , enlarged liver or both of these , severe headache, low blood sugar , and haemoglobin in

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4736-518: Is associated with potentially life-threatening conditions about as often as with a diagnosis of P. falciparum infection. P. vivax proportionally is more common outside Africa. Some cases have been documented of human infections with several species of Plasmodium from higher apes , but except for P. knowlesi —a zoonotic species that causes malaria in macaques —these are mostly of limited public health importance. The Anopheles mosquitos initially get infected by Plasmodium by taking

4884-446: Is caused by six Plasmodium species: P. falciparum , P. malariae , P. ovale curtisi , P. ovale wallikeri , P. vivax and P. knowlesi . Among those infected, P. falciparum is the most common species identified (~75%) followed by P. vivax (~20%). Although P. falciparum traditionally accounts for the majority of deaths, recent evidence suggests that P. vivax malaria

5032-465: Is deemed severe when any of the following criteria are present, otherwise it is considered uncomplicated. Cerebral malaria is defined as a severe P. falciparum -malaria presenting with neurological symptoms, including coma (with a Glasgow coma scale less than 11, or a Blantyre coma scale less than 3), or with a coma that lasts longer than 30 minutes after a seizure. Methods used to prevent malaria include medications, mosquito elimination and

5180-531: Is insufficient evidence that mosquito repellents can prevent malaria infection. Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are effective, have been commonly used to prevent malaria, and their use has contributed significantly to the decrease in malaria in the 21st century. ITNs and IRS may not be sufficient to eliminate the disease, as these interventions depend on how many people use nets, how many gaps in insecticide there are (low coverage areas), if people are not protected when outside of

5328-451: Is not available. In areas where the disease is common, malaria should be confirmed if possible before treatment is started due to concerns of increasing drug resistance . Resistance among the parasites has developed to several antimalarial medications; for example, chloroquine -resistant P. falciparum has spread to most malarial areas, and resistance to artemisinin has become a problem in some parts of Southeast Asia . The disease

5476-400: Is relatively invisible to immune surveillance. However, circulating infected blood cells are destroyed in the spleen . To avoid this fate, the P. falciparum parasite displays adhesive proteins on the surface of the infected blood cells, causing the blood cells to stick to the walls of small blood vessels, thereby sequestering the parasite from passage through the general circulation and

5624-449: Is sometimes due to malaria. Giving children with anaemia in these areas preventive antimalarial medication improves red blood cell levels slightly but does not affect the risk of death or need for hospitalisation. Vector control refers to methods used to decrease malaria by reducing the levels of transmission by mosquitoes. For individual protection, the most effective insect repellents are based on DEET or picaridin . However, there

5772-408: Is spread exclusively through bites of infected female Anopheles mosquitoes. The mosquito bite introduces the parasites from the mosquito's saliva into a person's blood. The parasites travel to the liver , where they mature and reproduce. Five species of Plasmodium commonly infect humans. The three species associated with more severe cases are P. falciparum (which is responsible for

5920-425: Is typical) to several years. After a period of dormancy, they reactivate and produce merozoites. Hypnozoites are responsible for long incubation and late relapses in P. vivax infections, although their existence in P. ovale is uncertain. The parasite is relatively protected from attack by the body's immune system because for most of its human life cycle it resides within the liver and blood cells and

6068-413: Is typically attributed to treatment failure. People may develop some immunity when exposed to frequent infections. Malaria infection develops via two phases: one that involves the liver (exoerythrocytic phase), and one that involves red blood cells, or erythrocytes (erythrocytic phase). When an infected mosquito pierces a person's skin to take a blood meal, sporozoites in the mosquito's saliva enter

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6216-818: Is widely used in Africa, where P. falciparum predominates. However, since HRP2 persists in the blood for up to five weeks after an infection is treated, an HRP2 test sometimes cannot distinguish whether someone currently has malaria or previously had it. Additionally, some P. falciparum parasites in the Amazon region lack the HRP2 gene, complicating detection. RDTs are fast and easily deployed to places without full diagnostic laboratories. However they give considerably less information than microscopy, and sometimes vary in quality from producer to producer and lot to lot. Serological tests to detect antibodies against Plasmodium from

6364-567: Is widespread in the tropical and subtropical regions that exist in a broad band around the equator . This includes much of sub-Saharan Africa , Asia , and Latin America . In 2022, some 249 million cases of malaria worldwide resulted in an estimated 608,000 deaths, with 80 percent being five years old or less. Around 95% of the cases and deaths occurred in sub-Saharan Africa. Rates of disease decreased from 2010 to 2014, but increased from 2015 to 2021. According to UNICEF, nearly every minute,

6512-692: The 1939 New York World's Fair , a semi-official flag and emblem for the League of Nations emerged: two five-pointed stars within a blue pentagon. They symbolised the Earth's five continents and "five races ". A bow at the top displayed the English name ("League of Nations"), while another at the bottom showed the French (" Société des Nations "). The League consisted of 42 founding members in November 1920. Six other states joined in its founding year (by December 1920), and seven more joined by September 1924, bringing

6660-581: The Axis powers in the 1930s. Its credibility was weakened because the United States never joined. Japan and Germany left in 1933, Italy left in 1937, and Spain left in 1939. The Soviet Union only joined in 1934 and was expelled in 1939 after invading Finland . Furthermore, the League demonstrated an irresolute approach to sanction enforcement for fear it might only spark further conflict, further decreasing its credibility. One example of this hesitancy

6808-651: The First World War . The main organisation ceased operations on 18 April 1946 when many of its components were relocated into the new United Nations . As the template for modern global governance, the League profoundly shaped the modern world. The League's primary goals were stated in its eponymous Covenant . They included preventing wars through collective security and disarmament and settling international disputes through negotiation and arbitration . Its other concerns included labour conditions, just treatment of native inhabitants, human and drug trafficking ,

6956-570: The Fourteen Points of January 1918), as well as the work of the Phillimore Commission. The outcome of House's work and Wilson's own first draft proposed the termination of "unethical" state behaviour, including forms of espionage and dishonesty. Methods of compulsion against recalcitrant states would include severe measures, such as "blockading and closing the frontiers of that power to commerce or intercourse with any part of

7104-644: The Islamic Organization for Medical Sciences , came up with the idea and donated the funding after taking into account the high frequency of Down syndrome in the Eastern Mediterranean region. The award, which consists of a bronze medal and the current equivalent of US$ 2,000, is given to one or more individuals who have distinguished themselves in Down syndrome research. The prize has been given out every two years since 2000. The foundation

7252-572: The Istituto Superiore di Sanità , with funds from the Italian Government. The prize awards US$ 10,000 travelling fellowships to keen researchers from developing countries to enable them to gain experience researching health issues that relate to developing countries. The Darling Foundation was established in 1929 in honour of eminent malaria expert Samuel Taylor Darling (1872–1925), who died tragically while participating in

7400-509: The Rockefeller Foundation . It made major grants designed to build up the technical expertise of the League staff. Ludovic Tournès argues that by the 1930s the foundations had changed the League from a "Parliament of Nations" to a modern think tank that used specialised expertise to provide an in-depth impartial analysis of international issues. The official languages of the League of Nations were French and English. During

7548-723: The Russian Empire in February 1917, followed by the German Empire , Austro-Hungarian Empire and Ottoman Empire . Anti-war sentiment rose across the world; the First World War was described as " the war to end all wars ", and its possible causes were vigorously investigated. The causes identified included arms races, alliances, militaristic nationalism, secret diplomacy, and the freedom of sovereign states to enter into war for their own benefit. One proposed remedy

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7696-526: The Treaty of Versailles , signed on 28 June 1919. French women's rights advocates invited international feminists to participate in a parallel conference to the Paris Conference in hopes that they could gain permission to participate in the official conference. The Inter-Allied Women's Conference asked to be allowed to submit suggestions to the peace negotiations and commissions and were granted

7844-621: The United Nations (UN) replaced it in 1946 and inherited several agencies and organisations founded by the League. Current scholarly consensus views that, even though the League failed to achieve its main goal of world peace , it did manage to build new roads towards expanding the rule of law across the globe; strengthened the concept of collective security , gave a voice to smaller nations; fostered economic stabilisation and financial stability , especially in Central Europe in

7992-519: The Women's International League for Peace and Freedom (WILPF). At the close of the conference, two delegations of women were dispatched to meet European heads of state over the next several months. They secured agreement from reluctant foreign ministers, who overall felt that such a body would be ineffective, but agreed to participate in or not impede creation of a neutral mediating body, if other nations agreed and if President Woodrow Wilson would initiate

8140-596: The Zürich Peace Conference held between 17 and 19 May 1919, the women of the WILPF condemned the terms of the Treaty of Versailles for both its punitive measures, as well as its failure to provide for condemnation of violence and exclusion of women from civil and political participation. Upon reading the Rules of Procedure for the League of Nations, Catherine Marshall , a British suffragist, discovered that

8288-411: The bone marrow for 11 days, then return to the blood circulation to await uptake by the bite of another mosquito. Once inside a mosquito, the gametocytes undergo sexual reproduction, and eventually form daughter sporozoites that migrate to the mosquito's salivary glands to be injected into a new host when the mosquito bites. The liver infection causes no symptoms; all symptoms of malaria result from

8436-491: The polymerase chain reaction to detect the parasite's DNA have been developed, but they are not widely used in areas where malaria is common, due to their cost and complexity. The risk of disease can be reduced by preventing mosquito bites through the use of mosquito nets and insect repellents or with mosquito-control measures such as spraying insecticides and draining standing water . Several medications are available to prevent malaria for travellers in areas where

8584-468: The 1920s; helped to raise awareness of problems like epidemics , slavery , child labour , colonial tyranny, refugee crises and general working conditions through its numerous commissions and committees; and paved the way for new forms of statehood, as the mandate system put the colonial powers under international observation. Professor David Kennedy portrays the League as a unique moment when international affairs were "institutionalised", as opposed to

8732-399: The Assembly for a three-year term. The first non-permanent members were Belgium , Brazil , Greece , and Spain . The composition of the Council was changed several times. The number of non-permanent members was first increased to six on 22 September 1922 and to nine on 8 September 1926. Werner Dankwort of Germany pushed for his country to join the League; joining in 1926, Germany became

8880-495: The Council of the League took place on 16 January 1920, and the first meeting of the Assembly of the League took place on 15 November 1920. In 1919, U.S. president Woodrow Wilson won the Nobel Peace Prize for his role as the leading architect of the League. The diplomatic philosophy behind the League represented a fundamental shift from the preceding hundred years. The League lacked its own armed force and depended on

9028-636: The Council take action aiming at the international organisation of intellectual work, which it did by adopting a report presented by the Fifth Committee of the Second Assembly and inviting a committee on intellectual co-operation to meet in Geneva in August 1922. The French philosopher Henri Bergson became the first chairman of the committee. The work of the committee included: an inquiry into

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9176-587: The Eastern Mediterranean. The foundation's purpose is to award a prize known as the Shousha Prize, which is to be given to a person who made the most significant contribution to any health problem in the geographical area in which Shousha served the WHO. The foundation also gives a fellowship every six years that amounts to US$ 15,000. The prize was founded in 1998 to promote the study of Down syndrome . Abdul Rahman Abdulla Al-Awadi , head of

9324-654: The IPU by 1914. Its foundational aims were to encourage governments to solve international disputes by peaceful means. Annual conferences were established to help governments refine the process of international arbitration. Its structure was designed as a council headed by a president, which would later be reflected in the structure of the League. At the start of the First World War, the first schemes for an international organisation to prevent future wars began to gain considerable public support, particularly in Great Britain and

9472-460: The League accused Italian soldiers of targeting International Red Cross and Red Crescent Movement medical tents, Benito Mussolini responded that "the League is very well when sparrows shout, but no good at all when eagles fall out." At its greatest extent from 28 September 1934 to 23 February 1935, it had 58 members. After some notable successes and some early failures in the 1920s, the League ultimately proved incapable of preventing aggression by

9620-400: The League as a solid replacement for a corrupt alliance system, a guardian of international order, and protector of small states," versus Lloyd George's desire for a "cheap, self-enforcing, peace, such as had been maintained by the old and more fluid Concert of Europe." Furthermore, the League, according to Carole Fink, was, "deliberately excluded from such great-power prerogatives as freedom of

9768-502: The League of Nations came into force. On 1 November 1920, the headquarters of the League was moved from London to Geneva , where the first General Assembly was held on 15 November 1920. Geneva made sense as an ideal city for the League, since Switzerland had been a neutral country for centuries and was already the headquarters for the International Red Cross. Its strong democracy and location in central Europe made it

9916-601: The League of Nations, Afghanistan abolished slavery in 1923, Iraq in 1924, Nepal in 1926, Transjordan and Persia in 1929, Bahrain in 1937, and Ethiopia in 1942. Led by Fridtjof Nansen , the Commission for Refugees was established on 27 June 1921 to look after the interests of refugees, including overseeing their repatriation and, when necessary, resettlement. At the end of the First World War, there were two to three million ex-prisoners of war from various nations dispersed throughout Russia; within two years of

10064-486: The League of Nations, the Inter-Parliamentary Union (IPU), was formed by the peace activists William Randal Cremer and Frédéric Passy in 1889 (and still exists as an international body focused on the world's various elected legislative bodies). The IPU was founded with an international scope, with a third of the members of parliaments (in the 24 countries that had parliaments) serving as members of

10212-467: The League on the grounds that "Ethiopia had not reached a state of civilisation and internal security sufficient to warrant her admission." The League also succeeded in reducing the death rate of workers constructing the Tanganyika railway from 55 to 4 per cent. Records were kept to control slavery, prostitution, and the trafficking of women and children . Partly as a result of pressure brought by

10360-652: The League's size to 55. Costa Rica withdrew in December 1924, making it the member to have most quickly withdrawn, and Brazil became the first founding member to withdraw in June 1926. Germany (under the Weimar Republic ) was admitted to the League of Nations through a resolution passed on 8 September 1926. The League's size remained at 54 for the next five years. Through the first half of the 1930s, six more states joined, including Iraq in 1932 (newly independent from

10508-466: The League. It resumed its participation in September 1933. The League's membership declined through the second half of the 1930s as it weakened. Between 1935 and the start of World War II in Europe in September 1939, only Egypt joined (becoming the last state to join), 11 members left, and 3 members ceased to exist or fell under military occupation (Ethiopia, Austria, and Czechoslovakia). The Soviet Union

10656-586: The League. The British were particularly active in setting up junior branches for secondary students. The League of Nations was relatively more universal and inclusive in its membership and structure than previous international organisations, but the organisation enshrined racial hierarchy by curtailing the right to self-determination and prevented decolonisation. At the Paris Peace Conference in 1919, Wilson, Cecil and Smuts all put forward their draft proposals. After lengthy negotiations between

10804-471: The League: representation had been accorded not only to governments but also to representatives of employers' and workers' organisations. Albert Thomas was its first director. The ILO successfully restricted the addition of lead to paint, and convinced several countries to adopt an eight-hour work day and forty-eight-hour working week. It also campaigned to end child labour, increase the rights of women in

10952-843: The Legal Status of Women sought to inquire into the status of women all over the world. It was formed in 1937, and later became part of the United Nations as the Commission on the Status of Women. Malaria Malaria is a mosquito-borne infectious disease that affects vertebrates and Anopheles mosquitoes. Human malaria causes symptoms that typically include fever , fatigue , vomiting , and headaches . In severe cases, it can cause jaundice , seizures , coma , or death . Symptoms usually begin 10 to 15 days after being bitten by an infected Anopheles mosquito . If not properly treated, people may have recurrences of

11100-574: The Paris-based Office international d'hygiène publique (OIHP) founded in 1907 after the International Sanitary Conferences , was discharging most of the practical health-related questions, and its relations with the League's Health Committee were often conflictual. The Health Committee's purpose was to conduct inquiries, oversee the operation of the League's health work, and prepare work to be presented to

11248-801: The Permanent Court of International Justice and several other agencies and commissions created to deal with pressing international problems. These included the Disarmament Commission, the International Labour Organization (ILO) , the Mandates Commission, the International Commission on Intellectual Cooperation (precursor to UNESCO ), the Permanent Central Opium Board , the Commission for Refugees,

11396-515: The Secretariat was responsible for preparing the agenda for the Council and the Assembly and publishing reports of the meetings and other routine matters, effectively acting as the League's civil service. In 1931 the staff numbered 707. The Assembly consisted of representatives of all members of the League, with each state allowed up to three representatives and one vote. It met in Geneva and, after its initial sessions in 1920, it convened once

11544-909: The Slavery Commission, and the Economic and Financial Organization . Three of these institutions were transferred to the United Nations after the Second World War: the International Labour Organization, the Permanent Court of International Justice (as the International Court of Justice ), and the Health Organisation (restructured as the World Health Organization ). The Permanent Court of International Justice

11692-471: The United States. Goldsworthy Lowes Dickinson , a British political scientist, coined the term "League of Nations" in 1914 and drafted a scheme for its organisation. Together with Lord Bryce , he played a leading role in the founding of the group of internationalist pacifists known as the Bryce Group , later the League of Nations Union . The group became steadily more influential among the public and as

11840-405: The absence of Duffy antigens on red blood cells. The impact of sickle cell trait on malaria immunity illustrates some evolutionary trade-offs that have occurred because of endemic malaria. Sickle cell trait causes a change in the haemoglobin molecule in the blood. Normally, red blood cells have a very flexible, biconcave shape that allows them to move through narrow capillaries ; however, when

11988-489: The arms trade, global health, prisoners of war, and protection of minorities in Europe. The Covenant of the League of Nations was signed on 28 June 1919 as Part I of the Treaty of Versailles , and it became effective with the rest of the Treaty on 10 January 1920. Australia was granted the right to participate as an autonomous member nation, marking the start of Australian independence on the global stage. The first meeting of

12136-418: The blood have been developed, but are not used for malaria diagnosis due to their relatively poor sensitivity and specificity. Highly sensitive nucleic acid amplification tests have been developed, but are not used clinically due to their relatively high cost, and poor specificity for active infections. Malaria is classified into either "severe" or "uncomplicated" by the World Health Organization (WHO). It

12284-430: The bloodstream and migrate to the liver where they infect hepatocytes, multiplying asexually and asymptomatically for a period of 8–30 days. After a potential dormant period in the liver, these organisms differentiate to yield thousands of merozoites, which, following rupture of their host cells, escape into the blood and infect red blood cells to begin the erythrocytic stage of the life cycle. The parasite escapes from

12432-540: The bloodstream. In the blood, the merozoites rapidly invade individual red blood cells , replicating over 24–72 hours to form 16–32 new merozoites. The infected red blood cell lyses, and the new merozoites infect new red blood cells, resulting in a cycle that continuously amplifies the number of parasites in an infected person. Over rounds of this infection cycle, a small portion of parasites do not replicate, but instead develop into early sexual stage parasites called male and female " gametocytes ". These gametocytes develop in

12580-408: The brain, they contribute to coma . In the placenta they contribute to low birthweight and preterm labor, and increase the risk of abortion and stillbirth. The destruction of red blood cells during infection often results in anemia, exacerbated by reduced production of new red blood cells during infection. Only female mosquitoes feed on blood; male mosquitoes feed on plant nectar and do not transmit

12728-434: The cause, recurrence can be classified as either recrudescence , relapse , or reinfection. Recrudescence is when symptoms return after a symptom-free period due to failure to remove blood-stage parasites by adequate treatment. Relapse is when symptoms reappear after the parasites have been eliminated from the blood but have persisted as dormant hypnozoites in liver cells. Relapse commonly occurs between 8 and 24 weeks after

12876-567: The commission's foundation, it had helped 425,000 of them return home. It established camps in Turkey in 1922 to aid the country with an ongoing refugee crisis, helping to prevent the spread of cholera , smallpox and dysentery as well as feeding the refugees in the camps. It also established the Nansen passport as a means of identification for stateless people . The Committee for the Study of

13024-518: The commission's results were later incorporated into the Covenant of the League of Nations . The French authorities also drafted a much more far-reaching proposal in June 1918; they advocated annual meetings of a council to settle all disputes, as well as an "international army" to enforce its decisions. American President Woodrow Wilson instructed Edward M. House to draft a US plan which reflected Wilson's own idealistic views (first articulated in

13172-516: The conditions of intellectual life, assistance to countries where intellectual life was endangered, creation of national committees for intellectual cooperation, cooperation with international intellectual organisations, protection of intellectual property, inter-university co-operation, co-ordination of bibliographical work and international interchange of publications, and international co-operation in archaeological research. The Slavery Commission sought to eradicate slavery and slave trading across

13320-492: The council or the Assembly. The Court was open to all the nations of the world under certain broad conditions. The International Labour Organization was created in 1919 on the basis of Part XIII of the Treaty of Versailles. The ILO, although having the same members as the League and being subject to the budget control of the Assembly, was an autonomous organisation with its own Governing Body, its own General Conference and its own Secretariat. Its constitution differed from that of

13468-436: The council. This body focused on ending leprosy , malaria , and yellow fever , the latter two by starting an international campaign to exterminate mosquitoes. The Health Organisation also worked successfully with the government of the Soviet Union to prevent typhus epidemics, including organising a large education campaign. Linked with health, but also commercial concerns, was the topic of narcotics control. Introduced by

13616-545: The course of the diplomatic efforts surrounding World War I , both sides had to clarify their long-term war aims. By 1916 in Britain, fighting on the side of the Allies , and in the neutral United States, long-range thinkers had begun to design a unified international organisation to prevent future wars. Historian Peter Yearwood argues that when the new coalition government of David Lloyd George took power in December 1916, there

13764-549: The creation of a mandate system for captured colonies of the Central Powers during the war. Cecil focused on the administrative side and proposed annual council meetings and quadrennial meetings for the Assembly of all members. He also argued for a large and permanent secretariat to carry out the League's administrative duties. According to historian Patricia Clavin, Cecil and the British continued their leadership of

13912-473: The delegates, the Hurst – Miller draft was finally produced as a basis for the Covenant . After more negotiation and compromise, the delegates finally approved of the proposal to create the League of Nations ( French : Société des Nations , German : Völkerbund ) on 25 January 1919. The final Covenant of the League of Nations was drafted by a special commission, and the League was established by Part I of

14060-521: The development of respiratory distress , which occurs in up to 25% of adults and 40% of children with severe P. falciparum malaria. Possible causes include respiratory compensation of metabolic acidosis , noncardiogenic pulmonary oedema , concomitant pneumonia , and severe anaemia . Although rare in young children with severe malaria, acute respiratory distress syndrome occurs in 5–25% of adults and up to 29% of pregnant women. Coinfection of HIV with malaria increases mortality. Kidney failure

14208-478: The development of a rules-based global order into the 1920s and 1930s, with a primary focus on the League of Nations. The British goal was to systematise and normalise the economic and social relations between states, markets, and civil society. They gave priority to business and banking issues, but also considered the needs of ordinary women, children and the family as well. They moved beyond high-level intellectual discussions, and set up local organisations to support

14356-509: The disease in the long run, but the initial costs required are out of reach of many of the world's poorest people. There is a wide difference in the costs of control (i.e. maintenance of low endemicity) and elimination programs between countries. For example, in China—whose government in 2010 announced a strategy to pursue malaria elimination in the Chinese provinces —the required investment is

14504-578: The disease is common. Occasional doses of the combination medication sulfadoxine/pyrimethamine are recommended in infants and after the first trimester of pregnancy in areas with high rates of malaria. As of 2023, two malaria vaccines have been endorsed by the World Health Organization . The recommended treatment for malaria is a combination of antimalarial medications that includes artemisinin . The second medication may be either mefloquine , lumefantrine , or sulfadoxine/pyrimethamine. Quinine , along with doxycycline , may be used if artemisinin

14652-475: The disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquito vector is itself harmed by Plasmodium infections, causing reduced lifespan. Human malaria is caused by single-celled microorganisms of the Plasmodium group. It

14800-462: The disease. Females of the mosquito genus Anopheles prefer to feed at night. They usually start searching for a meal at dusk, and continue through the night until they succeed. However, in Africa, due to the extensive use of bed nets, they began to bite earlier, before bed-net time. Malaria parasites can also be transmitted by blood transfusions , although this is rare. Symptoms of malaria can recur after varying symptom-free periods. Depending upon

14948-581: The exception of the Fabian Society in England, they maintained a legalistic approach that would limit the international body to a court of justice. The Fabians were the first to argue for a "council" of states, necessarily the Great Powers , who would adjudicate world affairs, and for the creation of a permanent secretariat to enhance international co-operation across a range of activities. In

15096-494: The eyes to turn together in the same direction), opisthotonus , seizures , or coma . Diagnosis based on skin odor profiles Humans emanate a large range of smells. Studies have been conducted on how to detect human malaria infections through volatile compounds from the skin - suggesting that volatile biomarkers may be a reliable source for the detection of infection, including those asymptomatic. Using skin body odor profiles can be efficient in diagnosing global populations, and

15244-431: The fifth permanent member of the Council. Later, after Germany and Japan both left the League, the number of non-permanent seats was increased from nine to eleven, and the Soviet Union was made a permanent member giving the council a total of fifteen members. The Council met, on average, five times a year and in extraordinary sessions when required. In total, 107 sessions were held between 1920 and 1939. The League oversaw

15392-441: The first Geneva Conventions establishing laws dealing with humanitarian relief during wartime, and the international Hague Conventions of 1899 and 1907 governing rules of war and the peaceful settlement of international disputes. Theodore Roosevelt at the acceptance for his Nobel Prize in 1910, said: "it would be a masterstroke if those great powers honestly bent on peace would form a League of Peace." One small forerunner of

15540-442: The frequency with which malaria parasites complete their life cycle in the cell. Individuals who are homozygous (with two copies of the abnormal haemoglobin beta allele ) have sickle-cell anaemia , while those who are heterozygous (with one abnormal allele and one normal allele) experience resistance to malaria without severe anaemia. Although the shorter life expectancy for those with the homozygous condition would tend to disfavour

15688-400: The guidelines were completely undemocratic and they were modified based on her suggestion. The League would be made up of a Assembly (representing all member states), a Council (with membership limited to major powers), and a permanent Secretariat. Member states were expected to "respect and preserve as against external aggression" the territorial integrity of other members and to disarm "to

15836-399: The highest attractiveness to anthropophilic mosquitoes. Some of these studies have included traps that had been baited with nylon socks previously worn by human participants and were deemed efficient in catching adult mosquitos. Foot odors have high numbers of volatile compounds, which in turn elicit an olfactory response from mosquitoes. Malaria has several serious complications , including

15984-429: The home, and an increase in mosquitoes that are resistant to insecticides. Modifications to people's houses to prevent mosquito exposure may be an important long term prevention measure. Mosquito nets help keep mosquitoes away from people and reduce infection rates and transmission of malaria. Nets are not a perfect barrier and are often treated with an insecticide designed to kill the mosquito before it has time to find

16132-596: The hope that each state would declare itself a free state that respects its citizens and welcomes foreign visitors as fellow rational beings, thus promoting peaceful society worldwide. International co-operation to promote collective security originated in the Concert of Europe that developed after the Napoleonic Wars in the 19th century in an attempt to maintain the status quo between European states and so avoid war. By 1910, international law developed, with

16280-423: The infection of red blood cells. Symptoms develop once there are more than around 100,000 parasites per milliliter of blood. Many of the symptoms associated with severe malaria are caused by the tendency of P. falciparum to bind to blood vessel walls, resulting in damage to the affected vessels and surrounding tissue. Parasites sequestered in the blood vessels of the lung contribute to respiratory failure . In

16428-502: The initial symptoms and is often seen in P. vivax and P. ovale infections. P. vivax malaria cases in temperate areas often involve overwintering by hypnozoites, with relapses beginning the year after the mosquito bite. Reinfection means that parasites were eliminated from the entire body but new parasites were then introduced. Reinfection cannot readily be distinguished from relapse and recrudescence, although recurrence of infection within two weeks of treatment ending

16576-526: The issues of foreign policy should be known to and controlled by public opinion." The 'Proposals' of the Bryce Group were circulated widely, both in England and the US, where they had a profound influence on the nascent international movement. In January 1915, a peace conference directed by Jane Addams was held in the neutral United States. The delegates adopted a platform calling for creation of international bodies with administrative and legislative powers to develop

16724-634: The liver undetected by wrapping itself in the cell membrane of the infected host liver cell. Within the red blood cells, the parasites multiply further, again asexually, periodically breaking out of their host cells to invade fresh red blood cells. Several such amplification cycles occur. Thus, classical descriptions of waves of fever arise from simultaneous waves of merozoites escaping and infecting red blood cells. Some P. vivax sporozoites do not immediately develop into exoerythrocytic-phase merozoites, but instead, produce hypnozoites that remain dormant for periods ranging from several months (7–10 months

16872-535: The lowest point consistent with domestic safety." All states were required to submit complaints for arbitration or judicial inquiry before going to war. The Council would create a Permanent Court of International Justice to make judgements on the disputes. Despite Wilson's efforts to establish and promote the League, for which he was awarded the Nobel Peace Prize in October 1919, the United States never joined. Senate Republicans led by Henry Cabot Lodge wanted

17020-431: The metabolism of glycerol, lactic acid, amino acids, and lipids - through the action of bacteria found within the skin. They create a “chemical signature” for the mosquitoes to locate a potential host, humans in particular. Lactic acid Lactic acid, a naturally produced levorotatory isomer, has been titled an attractant of mosquitoes for a long time. Lactic acid is predominantly produced by eccrine-sweat glands, creating

17168-504: The modified haemoglobin S molecules are exposed to low amounts of oxygen, or crowd together due to dehydration, they can stick together forming strands that cause the cell to distort into a curved sickle shape. In these strands, the molecule is not as effective in taking or releasing oxygen, and the cell is not flexible enough to circulate freely. In the early stages of malaria, the parasite can cause infected red cells to sickle, and so they are removed from circulation sooner. This reduces

17316-637: The parasite eventually disappears from that area, as happened in North America, Europe, and parts of the Middle East. However, unless the parasite is eliminated from the whole world, it could re-establish if conditions revert to a combination that favors the parasite's reproduction. Furthermore, the cost per person of eliminating anopheles mosquitoes rises with decreasing population density, making it economically unfeasible in some areas. Prevention of malaria may be more cost-effective than treatment of

17464-413: The pre-First World War methods of law and politics. The concept of a peaceful community of nations had been proposed as early as 1795, when Immanuel Kant 's Perpetual Peace: A Philosophical Sketch outlined the idea of a league of nations to control conflict and promote peace between states. Kant argued for the establishment of a peaceful world community, not in a sense of a global government, but in

17612-456: The prevention of bites. As of 2023, there are two malaria vaccines , approved for use in children by the WHO: RTS,S and R21 . The presence of malaria in an area requires a combination of high human population density, high Anopheles mosquito population density and high rates of transmission from humans to mosquitoes and from mosquitoes to humans. If any of these is lowered sufficiently,

17760-411: The richest (71%) and the poorest (53%) households. Malaria is usually confirmed by the microscopic examination of blood films or by antigen -based rapid diagnostic tests (RDT). Microscopy—i.e. examining Giemsa -stained blood with a light microscope —is the gold standard for malaria diagnosis. Microscopists typically examine both a "thick film" of blood, allowing them to scan many blood cells in

17908-509: The right to sit on commissions dealing specifically with women and children. Though they asked for enfranchisement and full legal protection under the law equal with men, those rights were ignored. Women won the right to serve in all capacities, including as staff or delegates in the League of Nations organisation. They also won a declaration that member nations should prevent trafficking of women and children and should equally support humane conditions for children, women and men labourers. At

18056-437: The screening and monitoring of infection to officially eradicate malaria. Research findings have predominantly relied on chemical explanations to explain the differences in attractiveness among humans based on distinct odor profiles. The existence of volatile compounds, like fatty acids, and lactic acid is an essential reason on why some individuals are more appealing to mosquitos than others. Volatile compounds Kanika Khanna,

18204-548: The seas and naval disarmament, the Monroe Doctrine and the internal affairs of the French and British empires, and inter-Allied debts and German reparations, not to mention the Allied intervention and the settlement of borders with Soviet Russia." Although the United States never joined, unofficial observers became more and more involved, especially in the 1930s. American philanthropies became heavily involved, especially

18352-545: The seat of the League at Geneva, comprised a body of experts in various spheres under the direction of the general secretary . Its principal sections were Political, Financial and Economics, Transit, Minorities and Administration (administering the Saar and Danzig ), Mandates, Disarmament, Health, Social (Opium and Traffic in Women and Children), Intellectual Cooperation and International Bureaux, Legal, and Information. The staff of

18500-494: The second International Opium Convention , the Permanent Central Opium Board had to supervise the statistical reports on trade in opium , morphine, cocaine and heroin. The board also established a system of import certificates and export authorisations for the legal international trade in narcotics . The League of Nations had devoted serious attention to the question of international intellectual cooperation since its creation. The First Assembly in December 1920 recommended that

18648-563: The spleen. The blockage of the microvasculature causes symptoms such as those in placental malaria. Sequestered red blood cells can breach the blood–brain barrier and cause cerebral malaria. Due to the high levels of mortality and morbidity caused by malaria—especially the P. falciparum species—it has placed the greatest selective pressure on the human genome in recent history. Several genetic factors provide some resistance to it including sickle cell trait , thalassaemia traits, glucose-6-phosphate dehydrogenase deficiency , and

18796-612: The trait's survival, the trait is preserved in malaria-prone regions because of the benefits provided by the heterozygous form. Liver dysfunction as a result of malaria is uncommon and usually only occurs in those with another liver condition such as viral hepatitis or chronic liver disease . The syndrome is sometimes called malarial hepatitis . While it has been considered a rare occurrence, malarial hepatopathy has seen an increase, particularly in Southeast Asia and India. Liver compromise in people with malaria correlates with

18944-415: The urine with kidney failure may occur. Complications may include spontaneous bleeding, coagulopathy , and shock . Malaria during pregnancy can cause stillbirths , infant mortality , miscarriage , and low birth weight , particularly in P. falciparum infection, but also with P. vivax . Malaria is caused by infection with parasites in the genus Plasmodium . In humans, malaria

19092-424: The urine , retinal damage , and convulsions . The classic symptom of malaria is paroxysm —a cyclical occurrence of sudden coldness followed by shivering and then fever and sweating, occurring every two days ( tertian fever ) in P. vivax and P. ovale infections, and every three days ( quartan fever ) for P. malariae . P. falciparum infection can cause recurrent fever every 36–48 hours, or

19240-401: The vast majority of malaria deaths), P. vivax , and P. knowlesi (a simian malaria that spills over into thousands of people a year). P. ovale and P. malariae generally cause a milder form of malaria. Malaria is typically diagnosed by the microscopic examination of blood using blood films , or with antigen-based rapid diagnostic tests . Methods that use

19388-533: The victorious Allied Powers of World War I (Britain, France, Italy and Japan were the initial permanent members of the Council) to enforce its resolutions, keep to its economic sanctions, or provide an army when needed. The Great Powers were often reluctant to do so. Sanctions could hurt League members, so they were reluctant to comply with them. During the Second Italo-Ethiopian War , when

19536-672: The workplace, and make shipowners liable for accidents involving seamen. After the demise of the League, the ILO became an agency of the United Nations in 1946. The League's Health Organisation had three bodies: the Health Bureau, containing permanent officials of the League; the General Advisory Council or Conference, an executive section consisting of medical experts; and the Health Committee. In practice,

19684-463: The world and to use any force that may be necessary..." The two principal drafters and architects of the covenant of the League of Nations were the British politician Lord Robert Cecil and the South African statesman Jan Smuts . Smuts's proposals included the creation of a council of the great powers as permanent members and a non-permanent selection of the minor states. He also proposed

19832-427: The world where malaria is common were protected by an ITN. That number increased to 20.3 million (18.5%) African children using ITNs in 2007, leaving 89.6 million children unprotected and to 68% African children using mosquito nets in 2015. The percentage of children sleeping under ITNs in sub-Saharan Africa increased from less than 40% in 2011 to over 50% in 2021. Most nets are impregnated with pyrethroids ,

19980-406: The world, and fought forced prostitution. Its main success was through pressing the governments who administered mandated countries to end slavery in those countries. The League secured a commitment from Ethiopia to end slavery as a condition of membership in 1923, and worked with Liberia to abolish forced labour and intertribal slavery. The United Kingdom had not supported Ethiopian membership of

20128-520: Was a founding member of WHO and signed the Organization's Constitution on behalf of France at the 1946 International Health Conference in New York. The foundation's goal is to promote social medicine or public health research by providing fellowships, which are given out every two years (even years). A bronze medal and a value of US$ 5,000 make up the prize. It was discontinued in 2015. The award

20276-409: Was allocated by the Assembly (the League was supported financially by its member states). The relations between the assembly and the council and the competencies of each were for the most part not explicitly defined. Each body could deal with any matter within the sphere of competence of the league or affecting peace in the world. Particular questions or tasks might be referred to either. Unanimity

20424-399: Was awarded every two years until it was discontinued in 2000. League of Nations The League of Nations ( LN or LoN ; French : Société des Nations [sɔsjete de nɑsjɔ̃] , SdN ) was the first worldwide intergovernmental organisation whose principal mission was to maintain world peace . It was founded on 10 January 1920 by the Paris Peace Conference that ended

20572-417: Was established in 2019 to celebrate a person(s) or institution(s) that made a significant contribution to health promotion extended far beyond the call of normal duties. The award consists of a plaque. In 1966, the 9th World Health Assembly established a foundation bearing Aly Tewfik Shousha (1891–1964) to honour the memory as one of the World Health Organization founders and first WHO regional director for

20720-517: Was expelled on 14 December 1939 for invading Finland , as one of the last acts of the League before it ceased functioning. The main constitutional organs of the League were the Assembly, the council, and the Permanent Secretariat. It also had two essential wings: the Permanent Court of International Justice and the International Labour Organization . In addition, there were several auxiliary agencies and bodies. Each organ's budget

20868-439: Was formed in 2003 by the State of Kuwait and awarded an individual who has made an exceptional contribution to the prevention, control, or study of diabetes, cardiovascular disease, or cancer. The prize, which consists of a bronze medal and an amount of money estimated to be worth US$ 5,000, can be awarded to one or more people once a year. Established in 1991 in memory of Francesco Pocchiari (1924–1989), former Director-General of

21016-459: Was founded in 1987 to pay tribute to Comlan A. A. Quenum (1926–1984), a Beninese physician and the first African to serve as the regional director of the WHO, and is given to the individual deemed to have made the greatest contribution to enhancing health in the region of Africa. The prize is funded by the Government of Cameroon and consists of a bronze medal and a reward of US$ 2,000. The prize

21164-483: Was led by Walter Phillimore (and became known as the Phillimore Committee), but also included Eyre Crowe , William Tyrrell , and Cecil Hurst . The recommendations of the so-called Phillimore Commission included the establishment of a "Conference of Allied States" that would arbitrate disputes and impose sanctions on offending states. The proposals were approved by the British government, and much of

21312-407: Was provided for by the Covenant, but not established by it. The Council and the Assembly established its constitution. Its judges were elected by the Council and the Assembly, and its budget was provided by the latter. The Court was to hear and decide any international dispute which the parties concerned submitted to it. It might also give an advisory opinion on any dispute or question referred to it by

21460-469: Was required for the decisions of both the assembly and the council, except in matters of procedure and some other specific cases such as the admission of new members. This requirement was a reflection of the league's belief in the sovereignty of its component nations; the league sought a solution by consent, not by dictation. In case of a dispute, the consent of the parties to the dispute was not required for unanimity. The Permanent Secretariat, established at

21608-554: Was the Abyssinia Crisis , in which Italy's sanctions were only limited from the outset (coal and oil were not restricted), and later altogether abandoned despite Italy being declared the aggressors in the conflict. The onset of the Second World War in 1939 showed that the League had failed its primary purpose: to prevent another world war. It was largely inactive until its abolition. The League lasted for 26 years;

21756-432: Was the creation of an international organisation whose aim was to prevent future war through disarmament, open diplomacy, international co-operation, restrictions on the right to wage war, and penalties that made war unattractive. In London Balfour commissioned the first official report into the matter in early 1918, under the initiative of Lord Robert Cecil . The British committee was finally appointed in February 1918. It

21904-486: Was widespread discussion among intellectuals and diplomats of the desirability of establishing such an organisation. When Lloyd George was challenged by Wilson to state his position with an eye on the postwar situation, he endorsed such an organisation. Wilson himself included in his Fourteen Points in January 1918 a "league of nations to ensure peace and justice." British foreign secretary, Arthur Balfour , argued that, as

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