Ethyl methanesulfonate ( EMS ) is an organosulfur compound with the formula CH 3 SO 3 C 2 H 5 . It is the ethyl ester of methanesulfonic acid . A colorless liquid, it is classified as an alkylating agent . EMS is the most commonly used chemical mutagen in experimental genetics . Mutations induced by EMS exposure can then be studied in genetic screens or other assays.
18-625: (Redirected from Ems ) Ems or EMS may refer to: Places and rivers [ edit ] Domat/Ems , a Swiss municipality in the canton of Grisons Ems (river) (Eems), a river in northwestern Germany and northeastern Netherlands that discharges in the Dollart Bay Ems (Eder) , a river of Hesse, Germany, a tributary of the Eder River Ems (Chichester Harbour) , an English river with its mouth at Emsworth, Hampshire Bad Ems ,
36-1339: A Brazilian pharmaceutical company EMS Recordings , a 1949–1952 American experimental-music record label EMS Technologies , an American company Organizations [ edit ] Edinburgh Mathematical Society Environmental Media Services , an American nonprofit organization Estonian Mathematical Society European Monetary System , a former European monetary cooperation European Mathematical Society Schools [ edit ] United States [ edit ] Eagleview Middle School , El Paso County, Colorado Eastern Middle School , Montgomery County, Maryland Elwood Middle School , New York Penn State College of Earth and Mineral Sciences (commonly referred to as EMS), part of Penn State University, University Park, Pennsylvania Eastern Mennonite School , Harrisonburg, Virginia Eastern Mennonite Seminary , Harrisonburg, Virginia Elsewhere [ edit ] Earl Marriott Secondary School , Surrey, British Columbia, Canada English Martyrs School and Sixth Form College , Hartlepool, County Durham, England Exeter Mathematics School , Exeter, Devon, England EM Strasbourg Business School , Strasbourg, France Science and technology [ edit ] Physics, chemistry, and biology [ edit ] Electromagnetic suspension ,
54-600: A German town in Rhineland-Palatinate, until 1913 named Ems Businesses [ edit ] Eastern Mountain Sports , an outdoor retailer Eitzen Maritime Services , a Norwegian company Electronic Music Studios , a manufacturer of synthesizers Elektromreža Srbije , a Serbian electric utility company Event Marketing Solutions , a UK-based provider of vehicle-based marketing roadshows Ems-Chemie , Swiss chemical company EMS (pharmaceuticals) ,
72-443: A management system of an organization similar to a quality management system Engine monitoring system, data logging, display and alerting device, a simpler form of an aircraft engine-indicating and crew-alerting system Expected mean squares , in statistics Other uses [ edit ] Ems (ship) , an 1893 British iron sailing ship Express Mail Service , an international express postal service offered by members of
90-401: A method to suspend an object Electromagnetic spectrum , is the range of all possible electromagnetic radiation Ethyl methanesulfonate (or methanesulfonic acid ethyl ester), a mutagen European macroseismic scale , a scale used when measuring earthquakes intensity Environmental Mutagen Society Computer and engineering [ edit ] Electronics manufacturing services ,
108-419: A neurological condition Electrical muscle stimulation , a type of medical therapy, also referred to as Electro Myo-Stimulation , a technique used in sports training and rehabilitation Equine metabolic syndrome , a horse disease Other science and technology [ edit ] Earthen manure storage , structures for the storage of liquid livestock manure Environmental management system , part of
126-562: A rate of 5x10 to 5x10 per gene without substantial killing. A 5x10 per gene mutation rate observed in a typical EMS mutagenesis experiment of the model organism C. elegans , corresponds to a raw mutation rate of ~7x10 mutations per G/C base pair, or about 250 mutations within an originally mutagenized gamete (containing a ~100 Mbp, 36% GC haploid genome). Such a mutagenized gamete would have about 9 different loss-of-function mutations in genes, with 1 to 2 of these mutations being within essential genes and therefore lethal. However, since it
144-496: A recombination process catalyzed by the proteins specified by these six genes is employed in repairing EMS lethal lesions in DNA. Generally speaking EMS is unstable in water. It hydrolyzes to ethanol and methanesulfonic acid. At neutral to acidic pH at room temperature, it has a fairly long half-life of over 1 day. Therefore, EMS must be specifically degraded before disposal. Protocols call for degradation of EMS in an equal volume of
162-810: A stoichiometric fashion by reacting with the active site cysteine of the O-6-methylguanine-DNA methyltransferase repair protein. The in vivo half-life of O -ethylguanine was reported to be about 9 days in mouse brain, while it was about 1 day in mouse liver. EMS induces mitotic recombination in Saccharomyces cerevisiae . It was suggested that EMS damage to DNA may result in a repair process leading to genetic exchange. Bacteriophage T4 mutants defective in any one of six genes known to be required for genetic recombination were found to be more sensitive to inactivation by EMS than wild type bacteriophage. This finding suggests that
180-574: A trading system with a user interface for market data, indicators and order entry Medical and veterinary [ edit ] Emergency medical services , a service providing out-of-hospital acute care and transport Emergency Hospital Service , also known as the Emergency Medical Service, which provided centralised state-run medical care in World War II Britain Eosinophilia–myalgia syndrome ,
198-440: A type of company Electronic meeting system , a collaborative computer software Element management system , software to monitor and control network elements (devices) in telecommunications Emergency Management Services , a part of MS-Windows Energy management software , software to monitor and optimize energy consumption in buildings or communities Energy management system , a system to control, monitor, and optimize
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#1732766269982216-473: Is unlikely the same essential gene is mutated in independent gametes, and if loss of the essential gene did not kill the gamete itself, downstream gamete fusion often allows for survival of the resulting zygote and organism, as the now heterozygous non-functional mutated allele may be rescued by the still wildtype allele provided by the other gamete. The ethyl group of EMS reacts with guanine in DNA , forming
234-635: The Universal Postal Union Experimental Music Studios , computer music center at the University of Illinois E. M. S. Namboodiripad (1909–1998), Indian communist leader A US Navy hull classification symbol: Expeditionary medical ship (EMS) See also [ edit ] Ems Dispatch , a historical document EM (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
252-552: The abnormal base O -ethylguanine. During DNA replication , DNA polymerases that catalyze the process frequently place thymine, instead of cytosine, opposite O -ethylguanine. Following subsequent rounds of replication, the original G:C base pair can become an A:T pair (a transition mutation). This changes the genetic information, is often harmful to cells, and can result in disease . RNA polymerase can also place uridine (RNA analog of thymine) opposite an O -ethylguanine lesion. O -ethylguanine can be repaired in vivo in
270-586: The 💕 Domat may refer to: Domat/Ems , a municipality of the canton of Graubünden, Switzerland Jean Domat Domat (olive) , a Turkish olive see Olive#Cultivars Domatic number Domats is a commune of the Yonne département, in France Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with the title Domat . If an internal link led you here, you may wish to change
288-420: The generation and flow of Electric Power Engine management system, see engine control unit Enhanced Messaging Service , an extension to Short Message Service (SMS) for mobile phone Expanded Memory Specification , a memory specification for x86 PCs supported by DOS etc. Enterprise messaging system , a middleware system for sending messages between two or more clients Execution management system ,
306-667: The link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Domat&oldid=629079008 " Category : Disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Ethyl methanesulfonate EMS produces random mutations in genetic material by nucleotide substitution; particularly through G:C to A:T transitions induced by guanine alkylation . EMS typically produces only point mutations . Due to its potency and well understood mutational spectrum, EMS can induce mutations at
324-484: The title EMS . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=EMS&oldid=1242077748 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Domat From Misplaced Pages,
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