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37-710: The European Bioinformatics Institute ( EMBL-EBI ) is an intergovernmental organization (IGO) which, as part of the European Molecular Biology Laboratory (EMBL) family, focuses on research and services in bioinformatics . It is located on the Wellcome Genome Campus in Hinxton near Cambridge , and employs over 600 full-time equivalent (FTE) staff. Further, the EMBL-EBI hosts training programs that teach scientists

74-493: A treaty that acts as a charter creating the group. Treaties are formed when lawful representatives (governments) of several states go through a ratification process, providing the IGO with an international legal personality. Intergovernmental organizations are an important aspect of public international law . Intergovernmental organizations in a legal sense should be distinguished from simple groupings or coalitions of states, such as

111-735: A capitalist economy. The oldest regional organization is the Central Commission for Navigation on the Rhine , created in 1815 by the Congress of Vienna . There are several different reasons a state may choose membership in an intergovernmental organization. But there are also reasons membership may be rejected. Reasons for participation: Reasons for rejecting membership: Intergovernmental organizations are provided with privileges and immunities that are intended to ensure their independent and effective functioning. They are specified in

148-640: A fair trial . Otherwise, the organizations' immunities may be put in question in national and international courts. Some organizations hold proceedings before tribunals relating to their organization to be confidential, and in some instances have threatened disciplinary action should an employee disclose any of the relevant information. Such confidentiality has been criticized as a lack of transparency . The immunities also extend to employment law . In this regard, immunity from national jurisdiction necessitates that reasonable alternative means are available to effectively protect employees' rights; in this context,

185-854: A first instance Dutch court considered an estimated duration of proceedings before the Administrative Tribunal of the International Labour Organization of 15 years to be too long. An international organization does not pay taxes, is difficult to prosecute in court and is not obliged to provide information to any parliament. The United Nations focuses on five main areas: "maintaining peace and security , protecting human rights , delivering humanitarian aid , supporting sustainable development , and upholding international law ". UN agencies , such as UN Relief and Works Agency , are generally regarded as international organizations in their own right. Additionally,

222-534: A good resource for developmental projects in developing countries. The UN has to protect against any kind of human rights violation, and in the UN system, some specialized agencies, like ILO and United Nations High Commissioner for Refugees ( UNHCR ), work in the human rights' protection fields. The UN agency, ILO, is trying to end any kind of discrimination in the work field and child labor; after that, this agency promotes fundamental labor rights and to get safe and secure for

259-595: A variety of issues—was the League of Nations , founded on 10 January 1920 with a principal mission of maintaining world peace after World War I. The United Nations followed this model after World War II . This was signed on 26 June 1945, in San Francisco, at the conclusion of the United Nations Conference on International Organization, and came into force on 24 October 1945. Currently, the UN

296-410: A web browser. The stored data can be interacted with using a graphical UI, which supports the display of data in multiple resolution levels from karyotype, through individual genes, to nucleotide sequence. Originally centered on vertebrate animals as its main field of interest, since 2009 Ensembl provides annotated data regarding the genomes of plants, fungi, invertebrates, bacteria and other species, in

333-879: Is a collaborative project with Google DeepMind to make predicted protein structures from the AlphaFold AI system freely available to the scientific community. The first release of the database was in 2021; as of 2024, AlphaFold DB provides access to over 214 million protein structures. Intergovernmental organization Examples for international organizations include: UN General Assembly , World Trade Organization , African Development Bank , UN Economic and Social Council , UN Security Council , Asian Development Bank , International Bank for Reconstruction and Development , International Monetary Fund , International Finance Corporation , Inter-American Development Bank , United Nations Environment Programme. Scottish law professor James Lorimer has been credited with coining

370-401: Is freely and publicly available to the global community. The organization has five members: The wwPDB was founded in 2003 by RCSB PDB (USA), PDBe (Europe) and PDBj (Japan). In 2006 BMRB (USA) joined the wwPDB. EMDB (UK) joined in 2021. Each member's site can accept structural data and process the data. The processed data is sent to the "archive keeper". The RCSB PDB presently acts as

407-484: Is intended to be ensured by legal mechanisms that are internal to the intergovernmental organization itself and access to administrative tribunals. In the course of many court cases where private parties tried to pursue claims against international organizations, there has been a gradual realization that alternative means of dispute settlement are required as states have fundamental human rights obligations to provide plaintiffs with access to court in view of their right to

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444-419: Is provided, such as Basic Local Alignment Search Tool (BLAST) or Clustal Omega sequence alignment tool, enabling further data analysis. BLAST is an algorithm for comparing biomacromolecule primary structure, most often nucleotide sequence of DNA /RN, and amino acid sequence of proteins, stored in the bioinformatic databases, with the query sequence. The algorithm uses scoring of the available sequences against

481-817: Is the main IGO with its arms such as the United Nations Security Council (UNSC), the General Assembly (UNGA), the International Court of Justice (ICJ), the Secretariat (UNSA), the Trusteeship Council (UNTC) and the Economic and Social Council (ECOSOC). When defined as "organizations with at least three state parties, a permanent headquarters or secretariat, as well as regular meetings and budgets",

518-782: The G7 or the Quartet . Such groups or associations have not been founded by a constituent document and exist only as task groups . Intergovernmental organizations must also be distinguished from treaties. Many treaties (such as the North American Free Trade Agreement , or the General Agreement on Tariffs and Trade before the establishment of the World Trade Organization ) do not establish an independent secretariat and instead rely on

555-672: The International Telecommunication Union and other standards organizations ). Common types include: In regional organizations like the European Union , African Union , NATO , ASEAN and Mercosur , there are restrictions on membership due to factors such as geography or political regimes. To enter the European Union (EU), the states require different criteria; member states need to be European, liberal-democratic political system, and be

592-423: The "archive keeper". This ensures that there is only one version of the data which is identical for all users. The modified database is then made available to the other wwPDB members, each of whom makes the resulting structure files available through their websites to the public. (Data is accessed from the wwPDB website itself only through links to the member websites.) The member sites are more than just mirrors of

629-567: The Ensembl is a database organized around genomic data, maintained by the Ensembl Project . Tasked with the continuous annotation of the genomes of model organisms , Ensembl provides researchers a comprehensive resource of relevant biological information about each specific genome. The annotation of the stored reference genomes is automatic and sequence-based. Ensembl encompasses a publicly available genome database which can be accessed via

666-657: The French Emperor Napoleon. States then became the main decision makers who preferred to maintain their sovereignty as of 1648 at the Westphalian treaty that closed the 30 Years' War in Europe. The first and oldest international organization—being established employing a treaty, and creating a permanent secretariat, with a global membership—was the International Telecommunication Union (founded in 1865). The first general international organization—addressing

703-716: The UN such as the World Health Organization (which was made up of regional organizations such as PAHO that predated the UN). A few UN special agencies are very centralized in policy and decision-making, but some are decentralized; for example, the country-based projects or missions' directors and managers can decide what they want to do in the fields. The UN agencies have a variety of tasks based on their specialization and their interests. The UN agencies provide different kinds of assistance to low-income countries and middle-income countries, and this assistance would be

740-704: The United Nations has Specialized Agencies , which are organizations within the United Nations System that have their member states (often nearly identical to the UN Member States ) and are governed independently by them; examples include international organizations that predate the UN, such as the International Telecommunication Union , and the Universal Postal Union , as well as organizations that were created after

777-640: The distinction from international non-governmental organizations (INGOs), which are non-governmental organizations (NGOs) that operate internationally. These include international nonprofit organizations such as the World Organization of the Scout Movement , International Committee of the Red Cross and Médecins Sans Frontières , as well as lobby groups that represent the interests of multinational corporations. IGOs are established by

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814-585: The each entry are organized in logical sections (e.g. protein function, structure, expression, sequence or relevant publications), allowing a coordinated overview about the protein of interest. Links to external databases and original sources of data are also provided. In addition to standard search by the protein name/identifier, UniProt webpage houses tools for BLAST searching, sequence alignment or searching for proteins containing specific peptides. The AlphaFold Protein Structure Database (AlphaFold DB)

851-473: The final alignment of the sequences. The output of the Clustal Omega may be visualized in a guide tree (the phylogenetic relationship of the best-pairing sequences) or ordered by the mutual sequence similarity between the queries. The main advantage of Clustal Omega over other MSA tools (Muscle, ProbCons ) is its efficiency, while maintaining a significant accuracy of the results. Based at the EMBL-EBI,

888-539: The fundamentals of the work with biological data and promote the plethora of bioinformatic tools available for their research, both EMBL-EBI-based and not so. One of the roles of the EMBL-EBI is to index and maintain biological data in a set of databases, including Ensembl (housing whole genome sequence data), UniProt (protein sequence and annotation database) and Protein Data Bank (protein and nucleic acid tertiary structure database). A variety of online services and tools

925-630: The individual ventures of EMBL-EBI, Swiss Institute of Bioinformatics (SIB) (together maintaining Swiss-Prot and TrEMBL) and Protein Information Resource (PIR) (housing Protein Sequence Database), the increase in the global protein data generation led to their collaboration in the creation of UniProt in 2002. The protein entries stored in UniProt are cataloged by a unique UniProt identifier. The annotation data collected for

962-529: The jurisdiction of national courts. Certain privileges and immunities are also specified in the Vienna Convention on the Representation of States in their Relations with International Organizations of a Universal Character of 1975,. which however has so far not been signed by 35 states and is thus not yet in force (status: 2022). Rather than by national jurisdiction, legal accountability

999-467: The laborers. United Nations Environment Program(UNEP) is one of the UN's (United Nations) agencies and is an international organization that coordinates U.N. activities on the environment. An early prominent example of an international organization is the Congress of Vienna of 1814–1815, which was an international diplomatic conference to reconstitute the European political order after the downfall of

1036-569: The number of IGOs in the world increased from about 60 in 1940 to about 350 in 1980, after which it has remained roughly constant. Worldwide Protein Data Bank The Worldwide Protein Data Bank ( wwPDB ) is an organization that maintains the archive of macromolecular structure . Its mission is to maintain a single Protein Data Bank Archive of macromolecular structural data that

1073-511: The parties for their administration, for example by setting up a joint committee . Other treaties have established an administrative apparatus which was not deemed to have been granted binding legal authority. The broader concept wherein relations among three or more states are organized according to certain principles they hold in common is multilateralism . Intergovernmental organizations differ in function, membership, and membership criteria. They have various goals and scopes, often outlined in

1110-619: The purpose of realizing a common end". He distinguished between bilateral and multilateral organizations on one end and customary or conventional organizations on the other end. In his 1922 book An Introduction to the Study of International Organization , Potter argued that international organization was distinct from " international intercourse " (all relations between states), "international law" (which lacks enforcement) and world government . International Organizations are sometimes referred to as intergovernmental organizations (IGOs), to clarify

1147-431: The query by a scoring matrix such as BLOSUM 62. The highest scoring sequences represent the closest relatives of the query, in terms of functional and evolutionary similarity. The database search by BLAST requires input data to be in a correct format (e.g. FASTA , GenBank, PIR or EMBL format). Users may also designate the specific databases to be searched, select scoring matrices to be used and other parameters prior to

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1184-556: The sister project Ensembl Genomes . As of 2020, the various Ensembl project databases together house over 50,000 reference genomes. Protein Data Bank (PDB) is a database of three dimensional structures of biological macromolecules, such as proteins and nucleic acids. The data are typically obtained by X-ray crystallography or nuclear magnetic resonance spectroscopy (NMR spectroscopy), and submitted manually by structural biologists worldwide through PDB member organizations – PDBe , RCSB, PDBj and BMRB. The database can be accessed through

1221-635: The term "international organization" in a 1871 article in the Revue de Droit International et de Legislation Compare . Lorimer use the term frequently in his two-volume Institutes of the Law of Nations (1883, 1884). Other early uses of the term were by law professor Walther Schucking in works published in 1907, 1908 and 1909, and by political science professor Paul S. Reinsch in 1911. In 1935, Pitman B. Potter defined international organization as "an association or union of nations established or recognized by them for

1258-511: The tool run. The best hits in the BLAST results are ordered according to their calculated E-value (the probability of the presence of a similarly or higher-scoring hit in the database by chance). Clustal Omega is a multiple sequence alignment (MSA) tool that enables to find an optimal alignment of at least three and maximum of 4000 input DNA and protein sequences. Clustal Omega algorithm employs two profile Hidden Markov models (HMMs) to derive

1295-859: The treaties that give rise to the organization (such as the Convention on the Privileges and Immunities of the United Nations and the Agreement on the Privileges and Immunities of the International Criminal Court ), which are normally supplemented by further multinational agreements and national regulations (for example the International Organizations Immunities Act in the United States). The organizations are thereby immune from

1332-697: The treaty or charter . Some IGOs developed to fulfill a need for a neutral forum for debate or negotiation to resolve disputes. Others developed to carry out mutual interests with unified aims to preserve peace through conflict resolution and better international relations , promote international cooperation on matters such as environmental protection , to promote human rights , to promote social development (education, health care ), to render humanitarian aid , and to economic development . Some are more general in scope (the United Nations ) while others may have subject-specific missions (such as INTERPOL or

1369-670: The webpages of its members, including PDBe (housed at the EMBL-EBI). As a member of the Worldwide Protein Data Bank (wwPDB) consortium, PDBe aids in the joint mission of archiving and maintenance of macromolecular structure data. UniProt is an online repository of protein sequence and annotation data, distributed in UniProt Knowledgebase (UniProt KB), UniProt Reference Clusters (UniRef) and UniProt Archive (UniParc) databases. Originally conceived as

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