The Force is a metaphysical and ubiquitous power in the Star Wars fictional universe . "Force-sensitive" characters use the Force throughout the franchise. Heroes like the Jedi seek to "become one with the Force", matching their personal wills with the will of the Force, while the Sith and other villains exploit the Force and try to bend it toward their own selfish and destructive desires. The Force has been compared to aspects of several world religions, and the phrase " May the Force be with you " has become part of pop culture vernacular .
180-619: George Lucas created the concept of the Force to address character and plot developments in Star Wars (1977). He also wanted to "awaken a certain kind of spirituality" in young audiences, suggesting a belief in God without endorsing any specific religion. He developed the Force as a nondenominational religious concept, "distill[ed from] the essence of all religions", premised on the existence of God and distinct ideas of good and evil . Lucas said there
360-479: A National Film Board production, in which Kroitor says, "Many people feel that in the contemplation of nature and in communication with other living things, they become aware of some kind of force, or something, behind this apparent mask which we see in front of us, and they call it God". Although Lucas had Kroitor's line in mind specifically, Lucas said the underlying sentiment is universal and that "similar phrases have been used extensively by many different people for
540-485: A liver cell can have more than 2000. The mitochondrion is composed of compartments that carry out specialized functions. These compartments or regions include the outer membrane, intermembrane space , inner membrane , cristae , and matrix . Although most of a eukaryotic cell's DNA is contained in the cell nucleus , the mitochondrion has its own genome ("mitogenome") that is substantially similar to bacterial genomes. This finding has led to general acceptance of
720-487: A "Force-sensitive lineage" and suggesting that the Force can be used by anyone. Several Star Wars characters say " May the Force be with you " (or derivatives of it) and the expression has become a popular catchphrase . In 2005, "May the Force be with you" was chosen as number 8 on the American Film Institute 's 100 Years... 100 Movie Quotes list. May 4 is Star Wars Day , taken from the pun "May
900-423: A "spiritual force". According to The A.V. Club , The Last Jedi depicts the Force "closer to the sorcery of fairy tales and medieval romance than it's ever been." Eric Charles points out that the television films The Ewok Adventure (1984) and Ewoks: The Battle for Endor (1985), intended for children, are "fairy tales in a science fiction setting" which feature magic and other fairy tale motifs rather than
1080-453: A Pretty (how) Town , Filmmaker and 6-18-67 . He was passionate and interested in camerawork and editing, defining himself as a filmmaker as opposed to being a director, and he loved making abstract visual films that created emotions purely through non-narrative structures. In 1967, Lucas re-enrolled as a USC graduate student in film production. He began working under movie and logo designer Saul Bass and film editor Verna Fields for
1260-567: A bad side. We are part of the Force because we generate the power that makes the Force live. When we die, we become part of that Force, so we never really die; we continue as part of the Force." — George Lucas during a production meeting for The Empire Strikes Back Lucas and screenwriter Leigh Brackett decided that the Force and the Emperor would be the main concerns in The Empire Strikes Back (1980). The focus on
1440-498: A bunch of gobbledegook ". When writing The Force Awakens (2015) with Lawrence Kasdan , J. J. Abrams respected that Lucas had established midi-chlorians' effect on some characters' ability to use the Force. However, as a child, he interpreted Obi-Wan Kenobi 's explanation of the Force in Star Wars to mean that any character could use its power, and that the Force was more grounded in spirituality than science. Abrams retained
1620-688: A clique of film students known as The Dirty Dozen . He also became good friends with fellow acclaimed student filmmaker and future Indiana Jones collaborator, Steven Spielberg and Martin Scorsese . A group of friends, which included Chris Lewis and Don Glut , started the Clean Cut Cinema Club. Lucas, Kleiser and Lewis then formed a short-lived production company called Sunrise Productions with offices on Sunset Boulevard. There they would make up stage names for themselves, Lucas calling himself Lucas Beaumont. Their only project would be
1800-482: A concept. Although Chris Taylor suggested fans want less detail, not more, in explaining the Force, Chris Bell argues that the introduction of midi-chlorians provided depth to the franchise and fomented engagement among fans and franchise writers. Religion expert John D. Caputo writes, "In the 'Gospel according to Lucas' a world is conjured up in which the intractable oppositions that have tormented religious thinkers for centuries are reconciled ... The gifts that
1980-502: A deep rumble associated with aggressive use or a more high-pitched sound associated with benevolent use. Jedi with special training can continue to exist after death, and some interact with the living as "being[s] of light" referred to as "Force ghosts." Obi-Wan's spirit provides Luke with guidance at key moments in the original trilogy, and Yoda appears as a spirit to guide Luke in The Last Jedi . Voices of past Jedi help Rey at
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#17327868731432160-601: A donation to NYU through the Hobson/Lucas Family Foundation to establish the Martin Scorsese Institute of Global Cinematic Arts . Mitochondrion A mitochondrion ( pl. mitochondria ) is an organelle found in the cells of most eukaryotes , such as animals , plants and fungi . Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which
2340-563: A fifth force would carry two types of charge—one for the light side and one for the dark—and that each would be carried by its own particle. Nepomuk Otte, also from Georgia Tech, cautions that Newton's third law of motion says telekinesis would apply a force back on the Force-wielding character. Fabien Paillusson from the University of Lincoln argues that the Force of the Star Wars universe reflects our own quest for understanding
2520-462: A fundamental role in immunity by aiding in antiviral defense, pathogen elimination, inflammation, and immune cell recruitment. Mitochondria have long been recognized for their central role in the intrinsic pathway of apoptosis , a form of PCD. In recent decades, they have also been identified as a signalling hub for much of the innate immune system . The endosymbiotic origin of mitochondria distinguishes them from other cellular components, and
2700-401: A high enough midi-chlorian count to feel and use the Force. Midi-chlorians are sentient, and arguably were the first species to emerge in the Star Wars universe. The species was a foundation of all life, as some deemed life impossible without midi-chlorians, and ultimately resided in all living beings, connecting two aspects of the Force. The Living Force (also known as a spirit or life essence)
2880-804: A key supporter in the creation of the federal E-Rate program to provide broadband funding to schools and libraries, and the Lucas Museum of Narrative Art , a forthcoming art museum in Los Angeles developed with his wife, Mellody Hobson . Lucas was born and raised in Modesto, California , the son of Dorothy Ellinore Lucas (née Bomberger) and George Walton Lucas Sr., and is of German, Swiss-German, English, Scottish, and distant Dutch and French descent. His family attended Disneyland during its opening week in July 1955, and Lucas would remain enthusiastic about
3060-568: A large multisubunit protein called translocase in the outer membrane , which then actively moves them across the membrane. Mitochondrial pro-proteins are imported through specialised translocation complexes. The outer membrane also contains enzymes involved in such diverse activities as the elongation of fatty acids , oxidation of epinephrine , and the degradation of tryptophan . These enzymes include monoamine oxidase , rotenone -insensitive NADH-cytochrome c-reductase, kynurenine hydroxylase and fatty acid Co-A ligase . Disruption of
3240-529: A lengthy explanation of the Force of Others and introduces its Ashla light side and Bogan dark side. The Ashla and Bogan are mentioned 10 and 31 times, respectively, and the Force of Others plays a more prominent role in the story. In this draft, Luke Starkiller's mission is to retrieve the Kyber Crystal , which can intensify either the Ashla or Bogan powers. The film's shorter third draft has no references to
3420-465: A limited amount of ATP either by breaking the sugar produced during photosynthesis or without oxygen by using the alternate substrate nitrite . ATP crosses out through the inner membrane with the help of a specific protein , and across the outer membrane via porins . After conversion of ATP to ADP by dephosphorylation that releases energy, ADP returns via the same route. Pyruvate molecules produced by glycolysis are actively transported across
3600-1255: A lot of free energy from the reactants without breaking bonds of an organic fuel. The free energy put in to remove an electron from Fe is released at complex III when Fe of cytochrome c reacts to oxidize ubiquinol (QH 2 ): 2 Fe 3 + ( cyt c ) + QH 2 ⟶ 2 Fe 2 + ( cyt c ) + Q + 2 H + ( aq ) {\displaystyle {\ce {2Fe^{3+}(cyt\,c){}+QH2->2Fe^{2+}(cyt\,c){}+Q{}+2H+(aq)}}} Δ r G o ′ = − 30 kJ/mol {\displaystyle \Delta _{r}G^{o'}=-30{\text{ kJ/mol}}} The ubiquinone (Q) generated reacts, in complex I , with NADH: Q + H + ( aq ) + NADH ⟶ QH 2 + NAD + {\displaystyle {\ce {Q + H+(aq){}+ NADH -> QH2 + NAD+ {}}}} Δ r G o ′ = − 81 kJ/mol {\displaystyle \Delta _{r}G^{o'}=-81{\text{ kJ/mol}}} While
3780-554: A millionaire by the age of 30. He attended Modesto Junior College , where he studied anthropology , sociology, and literature, amongst other subjects. He also began shooting with an 8 mm camera, including filming car races. At this time, Lucas became interested in Canyon Cinema : screenings of underground , avant-garde 16 mm filmmakers like Jordan Belson , Stan Brakhage and Bruce Conner . Lucas and childhood friend John Plummer also saw classic European films of
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#17327868731433960-520: A mitochondrion: Mitochondria have folding to increase surface area, which in turn increases ATP (adenosine triphosphate) production. Mitochondria stripped of their outer membrane are called mitoplasts . The outer mitochondrial membrane , which encloses the entire organelle, is 60 to 75 angstroms (Å) thick. It has a protein-to-phospholipid ratio similar to that of the cell membrane (about 1:1 by weight). It contains large numbers of integral membrane proteins called porins . A major trafficking protein
4140-464: A producer of the Indiana Jones films, had been appointed as co-chair of Lucasfilm Ltd. It was reported that Kennedy would work alongside Lucas, who would remain chief executive and serve as co-chairman for at least one year, after which she would succeed him as the company's sole leader. With the sale of Lucasfilm to Disney, Lucas is currently Disney's second-largest single shareholder, after
4320-700: A reduction of oxidative stress . In neurons, concomitant increases in cytosolic and mitochondrial calcium act to synchronize neuronal activity with mitochondrial energy metabolism. Mitochondrial matrix calcium levels can reach the tens of micromolar levels, which is necessary for the activation of isocitrate dehydrogenase , one of the key regulatory enzymes of the Krebs cycle . The relationship between cellular proliferation and mitochondria has been investigated. Tumor cells require ample ATP to synthesize bioactive compounds such as lipids , proteins , and nucleotides for rapid proliferation. The majority of ATP in tumor cells
4500-496: A religion based on the Force. Practitioners of Jediism pray to and express gratitude to the Force. Scientists are mostly skeptical about a "real world" explanation for the Force. Astrophysicist Jeanne Cavelos says in The Science of Star Wars that explaining the Force is particularly difficult because "it does so many different things". Force powers like precognition imply the time travel of information. Cavelos explores
4680-470: A success. Lucas then created his own company, Lucasfilm, Ltd. , and directed the successful American Graffiti (1973). Lucas then set his sights on adapting Flash Gordon , an adventure serial from his childhood that he fondly remembered. When he was unable to obtain the rights, he set out to write an original space adventure that would eventually become Star Wars . Despite his success with his previous film, all but one studio turned Star Wars down. It
4860-554: A technical snag in cell fractionation techniques, the alleged ER vesicle contaminants that invariably appeared in the mitochondrial fraction have been re-identified as membranous structures derived from the MAM—the interface between mitochondria and the ER. Physical coupling between these two organelles had previously been observed in electron micrographs and has more recently been probed with fluorescence microscopy . Such studies estimate that at
5040-537: A toy, called the Force Trainer , which uses EEG to read users' beta waves to lift a training droid-themed ball with a shaft of air. The New Republic , Townhall , The Atlantic , and others have compared various political machinations to the "Jedi mind trick", a Force power used to undermine opponents' perceptions and willpower. Critic Tim Robley compared the Force to the ruby slippers from The Wizard of Oz (1939), with both being entities that send
5220-542: A tree; Lucas's seatbelt had snapped, ejecting him and thereby saving his life. However, his lungs were bruised from severe hemorrhaging and he required emergency medical treatment. This incident caused him to lose interest in racing as a career, but also inspired him to pursue his other interests. Lucas's father owned a stationery store, and had wanted George to work for him when he turned 18. Lucas had been planning to go to art school, but his father said he wouldn't pay for it. Lucas declared upon leaving home that he would be
5400-586: A troubled production but was a surprise hit, becoming the highest-grossing film at the time , winning six Academy Awards and sparking a cultural phenomenon . Lucas produced and co-wrote the sequels The Empire Strikes Back (1980) and Return of the Jedi (1983). With director Steven Spielberg , he created, produced, and co-wrote Indiana Jones films Raiders of the Lost Ark (1981), The Temple of Doom (1984), The Last Crusade (1989) and The Kingdom of
5580-482: A very good eye, and he thought visually," he recalled. At Plummer's recommendation, Lucas then transferred to the University of Southern California (USC) School of Cinematic Arts . USC was one of the earliest universities to have a school devoted to motion picture film . During the years at USC, Lucas shared a dorm room with Randal Kleiser . Along with classmates such as Walter Murch , Caleb Deschanel , Hal Barwood , John Milius and Matthew Robbins , they became
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5760-517: A very high protein-to-phospholipid ratio (more than 3:1 by weight, which is about 1 protein for 15 phospholipids). The inner membrane is home to around 1/5 of the total protein in a mitochondrion. Additionally, the inner membrane is rich in an unusual phospholipid, cardiolipin . This phospholipid was originally discovered in cow hearts in 1942, and is usually characteristic of mitochondrial and bacterial plasma membranes. Cardiolipin contains four fatty acids rather than two, and may help to make
5940-600: A warehouse in Van Nuys, California . After seeing the map for the location was zoned as light industrial , Lucas named the group Industrial Light and Magic, which became the Special Visual Effects department on Star Wars . Alongside Dykstra, other leading members of the original ILM team were Ken Ralston , Richard Edlund , Dennis Muren , Robert Blalack , Joe Johnston , Phil Tippett , Steve Gawley , Lorne Peterson and Paul Huston. By June 2013, Lucas
6120-427: A waste product of protein metabolism. A mutation in the genes regulating any of these functions can result in mitochondrial diseases . Mitochondrial proteins (proteins transcribed from mitochondrial DNA) vary depending on the tissue and the species. In humans, 615 distinct types of proteins have been identified from cardiac mitochondria, whereas in rats , 940 proteins have been reported. The mitochondrial proteome
6300-531: Is a conscious choice between good and bad, and "the world works better if you're on the good side". In 1970s San Francisco , where Lucas lived when he wrote the drafts that became Star Wars , New Age ideas that incorporated the concept of qi and other notions of a mystical life-force were "in the air" and widely embraced. Lucas used the term the Force to "echo" its use by Canadian cinematographer Roman Kroitor in Arthur Lipsett 's 21-87 (1963),
6480-500: Is a significant interplay between the mitochondrion and ER with regard to calcium. The calcium is taken up into the matrix by the mitochondrial calcium uniporter on the inner mitochondrial membrane . It is primarily driven by the mitochondrial membrane potential . Release of this calcium back into the cell's interior can occur via a sodium-calcium exchange protein or via "calcium-induced-calcium-release" pathways. This can initiate calcium spikes or calcium waves with large changes in
6660-526: Is an extension of Filoni's conversations with Lucas about the nature of the Force. Filoni credits the prequel films for better developing the concept of the Force, particularly the idea of a balance between the light and dark sides. Obi-Wan Kenobi describes the Force as "an energy field created by all living things" in Star Wars . In The Phantom Menace , Qui-Gon says microscopic lifeforms called midi-chlorians, which exist inside all living cells, allow some characters to be Force-sensitive; characters must have
6840-489: Is called chemiosmosis , and was first described by Peter Mitchell , who was awarded the 1978 Nobel Prize in Chemistry for his work. Later, part of the 1997 Nobel Prize in Chemistry was awarded to Paul D. Boyer and John E. Walker for their clarification of the working mechanism of ATP synthase. Under certain conditions, protons can re-enter the mitochondrial matrix without contributing to ATP synthesis. This process
7020-536: Is considered to be one of the most significant figures of the 20th-century New Hollywood movement, and a pioneer of the modern blockbuster . Despite this, he has remained an independent filmmaker away from Hollywood for most of his career. After graduating from the University of Southern California in 1967, Lucas moved to San Francisco and co-founded American Zoetrope with filmmaker Francis Ford Coppola . He wrote and directed THX 1138 (1971), based on his student short Electronic Labyrinth: THX 1138 4EB , which
7200-457: Is generated via the oxidative phosphorylation pathway (OxPhos). Interference with OxPhos cause cell cycle arrest suggesting that mitochondria play a role in cell proliferation. Mitochondrial ATP production is also vital for cell division and differentiation in infection in addition to basic functions in the cell including the regulation of cell volume, solute concentration , and cellular architecture. ATP levels differ at various stages of
7380-401: Is known as proton leak or mitochondrial uncoupling and is due to the facilitated diffusion of protons into the matrix. The process results in the unharnessed potential energy of the proton electrochemical gradient being released as heat. The process is mediated by a proton channel called thermogenin , or UCP1 . Thermogenin is primarily found in brown adipose tissue , or brown fat, and
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7560-458: Is never regenerated. It is the oxidation of the acetate portion of acetyl-CoA that produces CO 2 and water, with the energy thus released captured in the form of ATP. In the liver, the carboxylation of cytosolic pyruvate into intra-mitochondrial oxaloacetate is an early step in the gluconeogenic pathway, which converts lactate and de-aminated alanine into glucose, under the influence of high levels of glucagon and/or epinephrine in
7740-561: Is often found in unicellular organisms, while human liver cells have about 1000–2000 mitochondria per cell, making up 1/5 of the cell volume. The mitochondrial content of otherwise similar cells can vary substantially in size and membrane potential, with differences arising from sources including uneven partitioning at cell division, leading to extrinsic differences in ATP levels and downstream cellular processes. The mitochondria can be found nestled between myofibrils of muscle or wrapped around
7920-454: Is responsible for non-shivering thermogenesis. Brown adipose tissue is found in mammals, and is at its highest levels in early life and in hibernating animals. In humans, brown adipose tissue is present at birth and decreases with age. Mitochondrial fatty acid synthesis (mtFASII) is essential for cellular respiration and mitochondrial biogenesis. It is also thought to play a role as a mediator in intracellular signaling due to its influence on
8100-643: Is sometimes referred to in terms of "dark" and "light" sides, with villains like the Sith drawing on the dark side to act aggressively while the Jedi use the light side for defense and peace. According to Filoni, Lucas believed a character's intentions when using the Force—their "will to be selfless or selfish"—is what distinguishes light and dark sides. The Force is also used by characters who are neither Jedi nor Sith, such as Leia Organa and Kylo Ren . Characters throughout
8280-479: Is the energy generated by all living things. Through midi-chlorians, it is fed into the Cosmic Force, which bounds all things and communicates with living sentient beings. In 1981, Lucas compared using the Force to yoga , saying any character can use its power. Dave Filoni said in 2015 that all Star Wars characters are "Force intuitive": some characters, like Luke Skywalker , are aware of their connection to
8460-425: Is the pore-forming voltage-dependent anion channel (VDAC). The VDAC is the primary transporter of nucleotides , ions and metabolites between the cytosol and the intermembrane space. It is formed as a beta barrel that spans the outer membrane, similar to that in the gram-negative bacterial outer membrane . Larger proteins can enter the mitochondrion if a signaling sequence at their N-terminus binds to
8640-400: Is the space enclosed by the inner membrane. It contains about 2/3 of the total proteins in a mitochondrion. The matrix is important in the production of ATP with the aid of the ATP synthase contained in the inner membrane. The matrix contains a highly concentrated mixture of hundreds of enzymes, special mitochondrial ribosomes , tRNA , and several copies of the mitochondrial DNA genome . Of
8820-573: Is thought to be dynamically regulated. Mitochondria (or related structures) are found in all eukaryotes (except the Oxymonad Monocercomonoides ). Although commonly depicted as bean-like structures they form a highly dynamic network in the majority of cells where they constantly undergo fission and fusion . The population of all the mitochondria of a given cell constitutes the chondriome. Mitochondria vary in number and location according to cell type. A single mitochondrion
9000-405: Is used throughout the cell as a source of chemical energy . They were discovered by Albert von Kölliker in 1857 in the voluntary muscles of insects. Meaning a thread-like granule, the term mitochondrion was coined by Carl Benda in 1898. The mitochondrion is popularly nicknamed the "powerhouse of the cell", a phrase popularized by Philip Siekevitz in a 1957 Scientific American article of
9180-466: The Indiana Jones television prequel spinoff The Young Indiana Jones Chronicles (1992–93). There were unsuccessful projects, however, including More American Graffiti (1979), Willard Huyck 's Howard the Duck (1986), which was the biggest flop of Lucas's career, Coppola's Tucker: The Man and His Dream (1988) and Radioland Murders (1994) directed by Mel Smith . The animation studio Pixar
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#17327868731439360-485: The N -formylation of mitochondrial proteins , similar to that of bacterial proteins, can be recognized by formyl peptide receptors . Normally, these mitochondrial components are sequestered from the rest of the cell but are released following mitochondrial membrane permeabilization during apoptosis or passively after mitochondrial damage. However, mitochondria also play an active role in innate immunity, releasing mtDNA in response to metabolic cues. Mitochondria are also
9540-528: The National Film Board of Canada like Arthur Lipsett 's 21-87 , cameraman Jean-Claude Labrecque 's cinéma vérité 60 Cycles , the work of Norman McLaren and the documentaries of Claude Jutra . Lucas fell madly in love with pure cinema and quickly became prolific at making 16 mm nonstory noncharacter visual tone poems and cinéma vérité with such titles as Look at Life , Herbie , 1:42.08 , The Emperor , Anyone Lived in
9720-808: The National Mall in Washington, D.C., to commemorate American civil rights leader Martin Luther King Jr. On September 19, 2006, the University of Southern California announced that Lucas had donated $ 175–180 million to his alma mater to expand the film school. It is the largest single donation to USC and the largest gift to a film school anywhere. Previous donations led to the already-existing George Lucas Instructional Building and Marcia Lucas Post-Production building. In 2013, Lucas and his wife Mellody Hobson donated $ 25 million to
9900-537: The San Francisco Bay Area and co-founded the studio American Zoetrope with Coppola, hoping to create a liberating environment for filmmakers to direct outside the perceived oppressive control of the Hollywood studio system . Coppola thought Lucas's Electronic Labyrinth could be adapted into his first full-length feature film, which was produced by American Zoetrope as THX 1138 , but was not
10080-529: The Soviet Union to the Galactic Empire . The Gospel According to Star Wars says that Reagan's invocation of the Force was actually perverting Star Wars ' "self-dispossessing" (or other-focused) ethos: [The] blessing "May the Force be with you" is the expression of a hope for others ("May the Force be with you "), not for ourselves as with Reagan ("The Force is with us "). Moreover,
10260-620: The United States Air Force as an officer, but he was immediately turned down because of his numerous speeding tickets. He was later drafted by the United States Army for military service in Vietnam , but he was exempted from service after medical tests showed he had diabetes , the disease that killed his paternal grandfather. Lucas saw many inspiring films in class, particularly the visual films coming out of
10440-621: The United States House of Representatives subcommittee on Telecommunications and the Internet as the head of his Foundation to advocate for a free wireless broadband educational network. In 2012, Lucas sold Lucasfilm to The Walt Disney Company for a reported sum of $ 4.05 billion. It was widely reported at the time that Lucas intended to give the majority of the proceeds from the sale to charity. A spokesperson for Lucasfilm said: "George Lucas has expressed his intention, in
10620-513: The United States Information Agency , where he met his future wife Marcia Griffin . Working as a teaching instructor for a class of U.S. Navy students who were being taught documentary cinematography, Lucas directed the short film Electronic Labyrinth: THX 1138 4EB , which won first prize at the 1967–68 National Student film festival. Lucas was awarded a student scholarship by Warner Bros. to observe and work on
10800-445: The cell cycle and cell growth . Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. Mitochondria have been implicated in several human disorders and conditions, such as mitochondrial diseases , cardiac dysfunction , heart failure and autism . The number of mitochondria in a cell can vary widely by organism , tissue , and cell type. A mature red blood cell has no mitochondria, whereas
10980-421: The citric acid cycle , or the Krebs cycle, and oxidative phosphorylation . However, the mitochondrion has many other functions in addition to the production of ATP. A dominant role for the mitochondria is the production of ATP, as reflected by the large number of proteins in the inner membrane for this task. This is done by oxidizing the major products of glucose : pyruvate , and NADH , which are produced in
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#173278687314311160-463: The cytosol . However, large proteins must have a specific signaling sequence to be transported across the outer membrane, so the protein composition of this space is different from the protein composition of the cytosol . One protein that is localized to the intermembrane space in this way is cytochrome c . The inner mitochondrial membrane contains proteins with three types of functions: It contains more than 151 different polypeptides , and has
11340-564: The endosymbiotic hypothesis - that free-living prokaryotic ancestors of modern mitochondria permanently fused with eukaryotic cells in the distant past, evolving such that modern animals, plants, fungi, and other eukaryotes are able to respire to generate cellular energy . Mitochondria may have a number of different shapes. A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins . The two membranes have different properties. Because of this double-membraned organization, there are five distinct parts to
11520-404: The glycine cleavage system (GCS), mtFASII has an influence on energy metabolism. Other products of mtFASII play a role in the regulation of mitochondrial translation, FeS cluster biogenesis and assembly of oxidative phosphorylation complexes. Furthermore, with the help of mtFASII and acylated ACP, acetyl-CoA regulates its consumption in mitochondria. The concentrations of free calcium in
11700-832: The highest-grossing film of all time , displaced five years later by Spielberg's E.T. the Extra-Terrestrial . After the success of American Graffiti and prior to the beginning of filming on Star Wars , Lucas was encouraged to renegotiate for a higher fee for writing and directing Star Wars than the US$ 150,000 agreed. He declined to do so, instead negotiating for advantage in some of the as-yet-unspecified parts of his contract with Fox, in particular, ownership of licensing and merchandising rights (for novelizations , clothing, toys, etc.) and contractual arrangements for sequels. Lucasfilm has earned hundreds of millions of dollars from licensed games, toys, and collectibles created for
11880-514: The localization site for immune and apoptosis regulatory proteins, such as BAX , MAVS (located on the outer membrane ), and NLRX1 (found in the matrix ). These proteins are modulated by the mitochondrial metabolic status and mitochondrial dynamics. Mitochondria play a central role in many other metabolic tasks, such as: Some mitochondrial functions are performed only in specific types of cells. For example, mitochondria in liver cells contain enzymes that allow them to detoxify ammonia ,
12060-446: The sperm flagellum . Often, they form a complex 3D branching network inside the cell with the cytoskeleton . The association with the cytoskeleton determines mitochondrial shape, which can affect the function as well: different structures of the mitochondrial network may afford the population a variety of physical, chemical, and signalling advantages or disadvantages. Mitochondria in cells are always distributed along microtubules and
12240-425: The "Special Editions". The trilogy received further modifications and restorations for DVD releases in 2004, Blu-ray releases in 2011 and 4K releases released in 2019. Additionally, Lucas released a director's cut of THX 1138 in 2004, with the film re-cut and containing a number of CGI additions. The first Star Wars prequel was finished and released in 1999 as Episode I – The Phantom Menace , which would be
12420-452: The "secret sauce" of his movies. Lucas is the wealthiest film celebrity in the world. His personal net worth is estimated to be between $ 7.5–9.4 billion. Lucas has pledged to give half of his fortune to charity as part of an effort called The Giving Pledge led by Bill Gates and Warren Buffett to persuade America's richest individuals to donate their financial wealth to charities. In 1991, The George Lucas Educational Foundation
12600-628: The 1978 Star Wars Holiday Special for 20th Century Fox Television . That year, Lucas hired Los Angeles-based real-estate specialist Charles Weber to manage the company, telling him that he could keep the job as long as he made money. Lucas wanted the focus of the company to be making independent films, but the company gradually became enlarged from five employees to almost 100, increasing in middle management and running up costs. In 1980, after Weber asked Lucas for fifty million dollars to invest in other companies and suggested that they sell Skywalker Ranch to do so, Lucas fired Weber and had to let half of
12780-636: The Ashla, but it mentions the Bogan eight times and Luke is still driven to recover the Kyber Crystal. Lucas finished the fourth and near-final draft on January 1, 1976. This version trims "the Force of Others" to "the Force", makes a single reference to the Force's seductive " dark side ", distills an explanation of the Force to 28 words, and eliminates the Kyber Crystal. Producer Gary Kurtz , who studied comparative religion in college, had long discussions with Lucas about religion and philosophy throughout
12960-475: The CGI film Strange Magic , his first musical. The film was produced at Skywalker Ranch . Gary Rydstrom directed the movie. At the same time the sequel trilogy was announced, a fifth installment of the Indiana Jones series also entered pre-development phase with Harrison Ford and Steven Spielberg set to return. Lucas originally did not specify whether the selling of Lucasfilm would affect his involvement with
13140-835: The Chicago-based not-for-profit After School Matters, of which Hobson is the chair. On April 15, 2016, it was reported that Lucas had donated between $ 501,000 and $ 1 million through the Lucas Family Foundation (now the Hobson/Lucas Family Foundation) to the Obama Foundation , which is charged with overseeing the construction of the Barack Obama Presidential Center on Chicago's South Side . In 2021, Lucas and his wife Mellody Hobson made
13320-585: The Clones (2002) and Revenge of the Sith (2005). He last collaborated on the CGI-animated movie and television series of the same name, Star Wars: The Clone Wars (2008–2014, 2020), the war film Red Tails (2012) and the CGI film Strange Magic (2015). Lucas is also known for his collaboration with composer John Williams , who was recommended to him by Spielberg, and with whom he has worked for all
13500-406: The Clones . The final prequel, Episode III – Revenge of the Sith , began production in 2002 and was released in 2005. Numerous older fans and critics at the time considered the prequels more mixed compared to the original trilogy, though they were box office successes and popular with younger fans. In 2004, Lucas reflected that his transition from independent to corporate filmmaker mirrored
13680-474: The Clones and Revenge of the Sith , and featured the last Star Wars stories in which Lucas was involved in a major way. In 2012, Lucas self-funded and served as executive producer for Red Tails , a war film based on the exploits of the Tuskegee Airmen during World War II . He also took over directing of reshoots while director Anthony Hemingway worked on other projects. I'm moving away from
13860-535: The Crystal Skull (2008), and served as an executive producer, with a cursory involvement in pre and post-production, on The Dial of Destiny (2023). In 1997, Lucas re-released the original Star Wars trilogy as part of a Special Edition featuring several modifications; home media versions with further changes were released in 2004 and 2011. He returned to directing with a Star Wars prequel trilogy comprising The Phantom Menace (1999), Attack of
14040-528: The Emperor was later shifted to Return of the Jedi (1983), and the dark side of the Force was treated as The Empire Strikes Back ' s main villain. The Phantom Menace (1999) introduces midi-chlorians (or midichlorians ), microscopic creatures that connect characters to the Force. Lucas later requested a passage about midi-chlorians be retroactively added to notes written in August 1977 expanding on
14220-439: The Force "a mixture of what appears to be ESP and early Christian faith." It has been studied in a religious context from an academic perspective. The Magic of Myth compares the sharp distinction between the good "light side" and evil "dark side" of the Force to Zoroastrianism , which posits that "good and evil, like light and darkness, are contrary realities". The connectedness between the light and dark sides has been compared to
14400-472: The Force and how it works, the more it took away from its core meaning. Kotaku suggests Rian Johnson depicted more nuance in the Force in The Last Jedi than Lucas did in his films. According to Rob Weinert-Kendt, the "Force theme" in John Williams ' score represents the power and responsibility of wielding the Force. Paranormal abilities like the Force are a common device in science fiction, and
14580-483: The Force and science-fiction tropes . These Ewok films have been described as depicting "sorcery" that is distinct from the Force powers depicted in the first six Star Wars films. Drawing from the Star Wars roleplaying game sourcebook he co-authored in 1987, Bill Slavicsek says that "The Ewoks' mystical beliefs contain many references to the Force, though it is never named as such." In his 1977 review of Star Wars , Vincent Canby of The New York Times called
14760-458: The Force can do." Johnson observed that every Star Wars movie introduces new Force powers to meet that film's story needs. Star Wars Rebels producer Dave Filoni cites several influences on how the Force is used in the show. The character Bendu —named in homage to the term Lucas originally associated with the Jedi—does not align with the franchise's normal dark-or-light duality, and this role
14940-494: The Force has been compared to the role magic plays in the fantasy genre. The Star Wars films illustrate that characters not familiar with the particulars of the Force associate it with mysticism and magic, such as when an Imperial officer alludes to the "sorcerer's ways" of Darth Vader. The depiction of the Force in Star Wars has been compared to that of magic in Harry Potter , with the former being described as more of
15120-517: The Force, which is ... Lucas's tribute to something beyond science: imagination, the soul, God in man ... It appears in various contradictory and finally nonsensical guises, a facile and perfunctory bow to metaphysics. I wish that Lucas had had the courage of his materialistic convictions, instead dragging in a sop to a spiritual force the main thrust of the movie so cheerfully ignores. The introduction of midi-chlorians in The Phantom Menace
15300-498: The Force, while characters such as Han Solo draw upon the Force unconsciously. Filoni said the most potent Force users are characters whose midi-chlorian count provides a natural affinity for using the Force and who undertake intense training and discipline. Rogue One (2016) portrays the Force more as a religion "than simply a way to manipulate objects and people". In the years following the Great Jedi Purge depicted in
15480-419: The Force. It's depicted as ... something supernatural within this universe, but it's not the same thing as a personal god that Christians or Jews or Muslims might believe in. It's this impersonal force that is in some ways this neutral, impersonal energy that is out there to be used for good or for evil." At one point, Francis Ford Coppola suggested to George Lucas that they use their combined fortunes to start
15660-704: The Fourth be with you". The expression was intentionally similar to the Christian dominus vobiscum , "the Lord be with you". President Ronald Reagan in 1985 said "the Force is with us", referring to the United States , to create the Strategic Defense Initiative (itself often nicknamed Star Wars ) to protect against Soviet ballistic missiles . Some weeks earlier, Reagan had compared
15840-436: The Jedi masters enjoy have a perfectly plausible scientific basis, even if its ways are mysterious". Characters' faith in the Force reinforces Rogue One ' s message of hope. The A.V. Club said Rian Johnson's depiction of the Force in The Last Jedi goes "beyond George Lucas' original transcendental concept". Polygon said Johnson's film "democratize[s] the Force", depicting Force sensitivity in characters from outside
16020-571: The Jedi, Raiders of the Lost Ark , Indiana Jones and the Temple of Doom , and Indiana Jones and the Last Crusade ). After Lucas sold Lucasfilm to Disney, Williams stayed on board with the franchise, and continued to score the remaining three films of the " Skywalker Saga " ( The Force Awakens , The Last Jedi , and The Rise of Skywalker , for which he received a further three Oscar nominations), after which he announced his "retirement" from
16200-400: The Los Angeles staff go. By the same year, the corporate subsidiary had been discontinued and its business was absorbed into the various divisions of Lucasfilm. Lucas founded Industrial Light & Magic in 1975, he wanted his 1977 film Star Wars to include visual effects that had never been seen on film before. After discovering that the in-house effects department at 20th Century Fox
16380-565: The MAM provided insight into the mechanistic basis underlying such physiological processes as intrinsic apoptosis and the propagation of calcium signaling, but it also favors a more refined view of the mitochondria. Though often seen as static, isolated 'powerhouses' hijacked for cellular metabolism through an ancient endosymbiotic event, the evolution of the MAM underscores the extent to which mitochondria have been integrated into overall cellular physiology, with intimate physical and functional coupling to
16560-594: The MAM, which may comprise up to 20% of the mitochondrial outer membrane, the ER and mitochondria are separated by a mere 10–25 nm and held together by protein tethering complexes. Purified MAM from subcellular fractionation is enriched in enzymes involved in phospholipid exchange, in addition to channels associated with Ca signaling. These hints of a prominent role for the MAM in the regulation of cellular lipid stores and signal transduction have been borne out, with significant implications for mitochondrial-associated cellular phenomena, as discussed below. Not only has
16740-611: The Main Title Theme, the Force Theme (less commonly referred to as Obi Wan Kenobi's Theme), the Rebel Alliance Theme and Princess Leia's Theme (all introduced in this film) repeatedly. Subsequent films also added to the catalog of themes for different characters, factions, and locations. The score was released to critical acclaim and won Williams his third Academy Award for Best Original Score . The score
16920-454: The Whills, beings that "control the universe" and "feed off the Force." He elaborated that individuals function as "vehicles for the Whills to travel around in", and that midi-chlorians "communicate with the Whills [who] in a general sense ... are the Force." After selling Lucasfilm to Disney in 2012, Lucas said his biggest concern about the franchise's future was the Force being "muddled into
17100-586: The [ Star Wars ] blessing is precisely a request for hope for others (" May the Force be with you"), whereas Reagan's claim sounds like a possessive assertion ("The Force is with us"). George Lucas George Walton Lucas Jr. (born May 14, 1944) is an American filmmaker and philanthropist. He created the Star Wars and Indiana Jones franchises and founded Lucasfilm , LucasArts , Industrial Light & Magic and THX . He served as chairman of Lucasfilm before selling it to The Walt Disney Company in 2012. Nominated for four Academy Awards , he
17280-510: The area of the inner membrane is about five times as large as that of the outer membrane. This ratio is variable and mitochondria from cells that have a greater demand for ATP, such as muscle cells, contain even more cristae. Mitochondria within the same cell can have substantially different crista-density, with the ones that are required to produce more energy having much more crista-membrane surface. These folds are studded with small round bodies known as F 1 particles or oxysomes. The matrix
17460-417: The blood. Here, the addition of oxaloacetate to the mitochondrion does not have a net anaplerotic effect, as another citric acid cycle intermediate (malate) is immediately removed from the mitochondrion to be converted to cytosolic oxaloacetate, and ultimately to glucose, in a process that is almost the reverse of glycolysis . The enzymes of the citric acid cycle are located in the mitochondrial matrix, with
17640-404: The business ... From the company, from all this kind of stuff. —George Lucas on his future career plans In January 2012, Lucas announced his retirement from producing large blockbuster films, and instead re-focusing his career on smaller, independently budgeted features. In June 2012, it was announced that producer Kathleen Kennedy , a long-term collaborator with Steven Spielberg and
17820-410: The cell can regulate an array of reactions and is important for signal transduction in the cell. Mitochondria can transiently store calcium , a contributing process for the cell's homeostasis of calcium. Their ability to rapidly take in calcium for later release makes them good "cytosolic buffers" for calcium. The endoplasmic reticulum (ER) is the most significant storage site of calcium, and there
18000-440: The cell cycle suggesting that there is a relationship between the abundance of ATP and the cell's ability to enter a new cell cycle. ATP's role in the basic functions of the cell make the cell cycle sensitive to changes in the availability of mitochondrial derived ATP. The variation in ATP levels at different stages of the cell cycle support the hypothesis that mitochondria play an important role in cell cycle regulation. Although
18180-483: The characters' relationship. Chris Taylor called the Force "largely a mystery" in Star Wars . Taylor ascribes the "more poetic, more spiritual ... and more demonstrative" descriptions of the Force in The Empire Strikes Back to Lawrence Kasdan , who co-wrote the film, but says the film does little to expand audiences' understanding of it. In 1997, Lucas said that the more detail he articulated about
18360-470: The climax of The Rise of Skywalker , and Luke's and Leia's spirits watch over her at the film's conclusion. In an early draft of Return of the Jedi , Lucas planned to resurrect Obi-Wan and Yoda at the climax, and some drafts included scenes of the two helping Luke stop the Emperor. The final arc of The Clone Wars ' sixth season reveals that Qui-Gon Jinn learned how to transition into the "cosmic Force" from entities who represent various emotions; Yoda hears
18540-447: The company. The sale reflected Lucas's desire to stop the cash flow losses from his seven-year research projects associated with new entertainment technology tools, as well as his company's new focus on creating entertainment rather than tools. As of June 1983, Lucas was worth $ 60 million, but he met cash-flow difficulties following his divorce that year, concurrent with the sudden dropoff in revenues from Star Wars licenses following
18720-639: The creative differences between him and the producers of The Force Awakens . Lucas went on to say that he needed to support the company and its employees who were going to suffer financially. Lucas described the previous six Star Wars films as his "children" and defended his vision for them, while criticizing The Force Awakens for having a "retro feel", saying: "I worked very hard to make them completely different, with different planets, with different spaceships – you know, to make it new." Lucas also drew some criticism and subsequently apologized for his remark likening Disney to "white slavers". In 2015, Lucas wrote
18900-415: The creator and executive producer for a second Star Wars animated series on Cartoon Network, Star Wars: The Clone Wars which premiered with a feature film of the same name before airing its first episode. The supervising director for this animated series was Dave Filoni , who was chosen by Lucas and closely collaborated with him on its development. This series bridged the events between Attack of
19080-436: The cycle, increasing all the other intermediates as one is converted into the other. Hence, the addition of any one of them to the cycle has an anaplerotic effect, and its removal has a cataplerotic effect. These anaplerotic and cataplerotic reactions will, during the course of the cycle, increase or decrease the amount of oxaloacetate available to combine with acetyl-CoA to form citric acid. This in turn increases or decreases
19260-452: The cytosol. This type of cellular respiration , known as aerobic respiration , is dependent on the presence of oxygen . When oxygen is limited, the glycolytic products will be metabolized by anaerobic fermentation , a process that is independent of the mitochondria. The production of ATP from glucose and oxygen has an approximately 13-times higher yield during aerobic respiration compared to fermentation. Plant mitochondria can also produce
19440-667: The deceased Qui-Gon's voice in Attack of the Clones (2002), and he reveals in Revenge of the Sith that he has contact with Qui-Gon. A short story by Claudia Gray depicts Obi-Wan learning this technique from Qui-Gon in the years leading up to Star Wars . The Force plays an important role in several Star Wars plot lines. Anakin Skywalker's rise as a Jedi, descent into the Sith Lord Darth Vader, and redemption back to
19620-425: The distribution of these organelles is also correlated with the endoplasmic reticulum . Recent evidence suggests that vimentin , one of the components of the cytoskeleton, is also critical to the association with the cytoskeleton. The mitochondria-associated ER membrane (MAM) is another structural element that is increasingly recognized for its critical role in cellular physiology and homeostasis . Once considered
19800-486: The end of the trilogy. The success of the first Star Wars film also resulted in more attention focused on Lucas, both positive and negative, attracting wealth and fame, but also many people who wanted Lucas's financial backing or just to threaten him. Following the release of the first Star Wars film, Lucas worked extensively as a writer and producer, including on the many Star Wars spinoffs made for film, television and other media. Lucas acted as executive producer for
19980-426: The endomembrane system. The MAM is enriched in enzymes involved in lipid biosynthesis, such as phosphatidylserine synthase on the ER face and phosphatidylserine decarboxylase on the mitochondrial face. Because mitochondria are dynamic organelles constantly undergoing fission and fusion events, they require a constant and well-regulated supply of phospholipids for membrane integrity. But mitochondria are not only
20160-470: The enzymes, the major functions include oxidation of pyruvate and fatty acids , and the citric acid cycle . The DNA molecules are packaged into nucleoids by proteins, one of which is TFAM . The most prominent roles of mitochondria are to produce the energy currency of the cell, ATP (i.e., phosphorylation of ADP ), through respiration and to regulate cellular metabolism . The central set of reactions involved in ATP production are collectively known as
20340-458: The estate of Steve Jobs . Lucas worked as a creative consultant on the Star Wars sequel trilogy 's first film, The Force Awakens . Lucas's involvement included attending early story meetings; according to Lucas, "I mostly say, 'You can't do this. You can do that.' You know, 'The cars don't have wheels. They fly with antigravity.' There's a million little pieces ... I know all that stuff." Lucas's son Jett told The Guardian that his father
20520-506: The event the deal closes, to donate the majority of the proceeds to his philanthropic endeavors." Lucas also spoke on the matter: "For 41 years, the majority of my time and money has been put into the company. As I start a new chapter in my life, it is gratifying that I have the opportunity to devote more time and resources to philanthropy." In 2005, Lucas gave $ 1 million to help build the Martin Luther King Jr. Memorial on
20700-620: The exception of succinate dehydrogenase , which is bound to the inner mitochondrial membrane as part of Complex II. The citric acid cycle oxidizes the acetyl-CoA to carbon dioxide, and, in the process, produces reduced cofactors (three molecules of NADH and one molecule of FADH 2 ) that are a source of electrons for the electron transport chain , and a molecule of GTP (which is readily converted to an ATP). The electrons from NADH and FADH 2 are transferred to oxygen (O 2 ) and hydrogen (protons) in several steps via an electron transport chain. NADH and FADH 2 molecules are produced within
20880-453: The exposure of mitochondrial elements to the cytosol can trigger the same pathways as infection markers. These pathways lead to apoptosis , autophagy , or the induction of proinflammatory genes. Mitochondria contribute to apoptosis by releasing cytochrome c , which directly induces the formation of apoptosomes . Additionally, they are a source of various damage-associated molecular patterns (DAMPs). These DAMPs are often recognised by
21060-403: The film series into a "Saga". In 1994, Lucas began work on the screenplay of the first prequel, tentatively titled Episode I: The Beginning . In 1997, to celebrate the 20th anniversary of Star Wars , Lucas restored the original trilogy and made numerous modifications using newly available digital technology to bring them closer to his original vision. The films were re-released in theaters as
21240-512: The film. In October 2016, Lucas announced his decision to not be involved in the story of the film but would remain an executive producer. In 2016, Rogue One: A Star Wars Story , the first film of a Star Wars anthology series was released. It told the story of the rebels who stole the plans for the Death Star featured in the original Star Wars film, and it was reported that Lucas liked it more than The Force Awakens . The Last Jedi ,
21420-517: The films in both of these franchises. He also produced and wrote a variety of films and television series through Lucasfilm between the 1970s and the 2010s. Lucas is one of history's most financially successful filmmakers . He directed or wrote the story for ten of the 100 highest-grossing movies at the North American box office, adjusted for ticket-price inflation. Through his companies Industrial Light and Magic and Skywalker Sound , Lucas
21600-437: The first film Lucas had directed in over two decades. Following the release of the first prequel, Lucas announced that he would also be directing the next two, and began working on Episode II . The first draft of Episode II was completed just weeks before principal photography, and Lucas hired Jonathan Hales , a writer from The Young Indiana Jones Chronicles , to polish it. It was completed and released in 2002 as Attack of
21780-465: The first four Indiana Jones films, which his colleague and good friend Steven Spielberg directed. Craig Barron , who worked at ILM as part of the matte painting department, told Star Wars Insider that Lucas liked to spend time with the department's painters and often spoke of what movies he wanted to make. According to Barron, Lucas had wanted to make a film about Alexander the Great , but this film
21960-541: The forces of the world we live in. National Geographic compared the Higgs boson 's role as "carrier" of the Higgs field to the way Jedi are "carriers" of the Force. A previsualization video highlighting the idea of "kicking someone's ass with the Force" steered LucasArts game designers toward producing The Force Unleashed (2008), which sold six million copies as of July 2009. In 2009, Uncle Milton Industries released
22140-420: The franchise use their Force powers in myriad ways, including Obi-Wan using a "mind trick" to undermine a stormtrooper's will, Darth Vader choking subordinates without touching them, Qui-Gon Jinn repelling several battle droids at once, Rey lifting a large pile of rocks, and Kylo Ren stopping blaster fire in mid-air. Film and television use of the Force is sometimes accompanied by a sound effect, such as
22320-432: The franchise. The original Star Wars film went through a tumultuous production, and during editing, Lucas suffered chest pains initially feared to be a heart attack, but actually a fit of hypertension and exhaustion. The effort that Lucas exerted during post-production for the film, and its subsequent sequels, caused strains on his relationship with his wife Marcia Lucas, and was a contributing factor to their divorce at
22500-544: The idea of the Force having a light and a dark side, and some characters' seduction by the dark side helps create conflict for the story. Pablo Hidalgo of the Lucasfilm Story Group gave his "blessing" for writer-director Rian Johnson to introduce a new Force power in The Last Jedi (2017) "if the story required it and if it felt like it stretches into new territory but doesn't break the idea of what
22680-549: The inner membrane (TIM) complex or via OXA1L . In addition, there is a membrane potential across the inner membrane, formed by the action of the enzymes of the electron transport chain . Inner membrane fusion is mediated by the inner membrane protein OPA1 . The inner mitochondrial membrane is compartmentalized into numerous folds called cristae , which expand the surface area of the inner mitochondrial membrane, enhancing its ability to produce ATP. For typical liver mitochondria,
22860-410: The inner membrane impermeable, and its disruption can lead to multiple clinical disorders including neurological disorders and cancer. Unlike the outer membrane, the inner membrane does not contain porins, and is highly impermeable to all molecules. Almost all ions and molecules require special membrane transporters to enter or exit the matrix. Proteins are ferried into the matrix via the translocase of
23040-785: The inner mitochondrial membrane ( NADH dehydrogenase (ubiquinone) , cytochrome c reductase , and cytochrome c oxidase ). At complex IV , O 2 reacts with the reduced form of iron in cytochrome c : O 2 + 4 H + ( aq ) + 4 Fe 2 + ( cyt c ) ⟶ 2 H 2 O + 4 Fe 3 + ( cyt c ) {\displaystyle {\ce {O2{}+4H+(aq){}+4Fe^{2+}(cyt\,c)->2H2O{}+4Fe^{3+}(cyt\,c)}}} Δ r G o ′ = − 218 kJ/mol {\displaystyle \Delta _{r}G^{o'}=-218{\text{ kJ/mol}}} releasing
23220-434: The inner mitochondrial membrane, and into the matrix where they can either be oxidized and combined with coenzyme A to form CO 2 , acetyl-CoA , and NADH , or they can be carboxylated (by pyruvate carboxylase ) to form oxaloacetate. This latter reaction "fills up" the amount of oxaloacetate in the citric acid cycle and is therefore an anaplerotic reaction , increasing the cycle's capacity to metabolize acetyl-CoA when
23400-510: The lack of detail about the Force makes it "a religion for the secular age". According to Jennifer Porter, professor of religious studies at the Memorial University of Newfoundland , "the Force is a metaphor for godhood that resonates and inspires within [people] a deeper commitment to the godhood identified within their traditional faith". According to Christian Pastor Clayton Keenan, "the spirituality of 'Star Wars' has to do with
23580-460: The last 13,000 years". The first draft of Star Wars makes two references to "the Force of Others" and does not explain the concept: King Kayos utters the blessing "May the Force of Others be with you all", and he later says "I feel the Force also". The power of the Force of Others is kept secret by the Jedi Bendu of the Ashla, an "aristocratic cult" in the second draft. The second draft offers
23760-483: The levels of bioactive lipids, such as lysophospholipids and sphingolipids . Octanoyl-ACP (C8) is considered to be the most important end product of mtFASII, which also forms the starting substrate of lipoic acid biosynthesis. Since lipoic acid is the cofactor of important mitochondrial enzyme complexes, such as the pyruvate dehydrogenase complex (PDC), α-ketoglutarate dehydrogenase complex (OGDC), branched-chain α-ketoacid dehydrogenase complex (BCKDC), and in
23940-472: The light side of the Force is the main story arc for the first six Star Wars films. Yoda 's arc in the sixth season of The Clone Wars depicts him exploring "bigger questions" about the Force and taking various inspirations from the franchise's expanded universe . In The Force Awakens , Finn 's exposure to the Force helps make him question his training. Writer Rian Johnson used the Force to allow Rey and Kylo Ren to communicate in The Last Jedi , developing
24120-441: The making of a film of his choosing. The film he chose after finding the animation department closed down was Finian's Rainbow (1968) which was being directed by Francis Ford Coppola , who was revered among film school students of the time as a cinema graduate who had "made it" in Hollywood. In 1969, Lucas was one of the camera operators on the classic Rolling Stones concert film Gimme Shelter . In 1969, Lucas moved back to
24300-423: The matrix via the citric acid cycle and in the cytoplasm by glycolysis . Reducing equivalents from the cytoplasm can be imported via the malate-aspartate shuttle system of antiporter proteins or fed into the electron transport chain using a glycerol phosphate shuttle . The major energy-releasing reactions that make the mitochondrion the "powerhouse of the cell" occur at protein complexes I, III and IV in
24480-474: The membrane potential. These can activate a series of second messenger system proteins that can coordinate processes such as neurotransmitter release in nerve cells and release of hormones in endocrine cells. Ca influx to the mitochondrial matrix has recently been implicated as a mechanism to regulate respiratory bioenergetics by allowing the electrochemical potential across the membrane to transiently "pulse" from ΔΨ-dominated to pH-dominated, facilitating
24660-434: The metaphor, saying society is the same way, says we all must get along with each other. In a rough draft of Revenge of the Sith (2005), Palpatine says he "used the power of the Force to will the midichlorians to start the cell divisions that created" Anakin Skywalker. This line was removed as the script progressed. Lucas' story treatments for a potential sequel trilogy involved "a microbiotic world" and creatures known as
24840-479: The mitochondria and may contribute to the decline in mitochondrial function associated with aging. As the proton concentration increases in the intermembrane space, a strong electrochemical gradient is established across the inner membrane. The protons can return to the matrix through the ATP synthase complex, and their potential energy is used to synthesize ATP from ADP and inorganic phosphate (P i ). This process
25020-538: The museum in California. On January 17, 2017, Lucas announced that an eleven-acre campus with green space and the museum's five-story 300,000 square foot building will be constructed over what was a parking lot in Exposition Park , Los Angeles, California. It is due to be completed in 2025. Lucas was also heavily involved and invested in the scoring process for the original Star Wars soundtrack , which
25200-586: The nature of the Force. Lucas based the concept on symbiogenesis , calling midi-chlorians a "loose depiction" of mitochondria . He further said: [Mitochondria] probably had something ... to do with the beginnings of life and how one cell decided to become two cells with a little help from this other little creature who came in, without whom life couldn't exist. And it's really a way of saying we have hundreds of little creatures who live on us, and without them, we all would die. There wouldn't be any life. They are necessary for us; we are necessary for them. Using them in
25380-484: The never completed short "Five, Four, Three", a self-referential and self-deprecating mockumentary about the making of a satirical teen beach movie called "Orgy Beach Party". Lucas was deeply influenced by the Filmic Expression course taught at the school by filmmaker Lester Novros which concentrated on the non-narrative elements of Film Form like color, light, movement, space, and time. Another inspiration
25560-536: The next two Star Wars films, commissioning Irvin Kershner to direct The Empire Strikes Back and Richard Marquand to direct Return of the Jedi , while receiving a story credit on the former and sharing a screenwriting credit with Lawrence Kasdan on the latter. Lucas also gave away his screenwriting credit out of great respect for Leigh Brackett for The Empire Strikes Back after her death from cancer. He also acted as story writer and executive producer on
25740-409: The outer membrane are small (diameter: 60 Å) particles named sub-units of Parson. The mitochondrial intermembrane space is the space between the outer membrane and the inner membrane. It is also known as perimitochondrial space. Because the outer membrane is freely permeable to small molecules, the concentrations of small molecules, such as ions and sugars, in the intermembrane space is the same as in
25920-478: The outer membrane permits proteins in the intermembrane space to leak into the cytosol, leading to cell death. The outer mitochondrial membrane can associate with the endoplasmic reticulum (ER) membrane, in a structure called MAM (mitochondria-associated ER-membrane). This is important in the ER-mitochondria calcium signaling and is involved in the transfer of lipids between the ER and mitochondria. Outside
26100-591: The park. He was interested in comics and science fiction, including television programs such as the Flash Gordon serials. Long before Lucas began making films, he yearned to be a racecar driver, and he spent most of his high school years racing on the underground circuit at fairgrounds and hanging out at garages. On June 12, 1962, a few days before his high school graduation, Lucas was driving his souped-up Autobianchi Bianchina when another driver broadsided him, flipping his car several times before it crashed into
26280-528: The possibility of brain implants or sensors being used to detect users' intent and manipulate energy fields, and compares such discipline to contemporary patients learning to control prosthetics . A scientific explanation of the Force would require new discoveries in physics, such as unknown fields or particles or a fifth force beyond the four fundamental interactions . Flavio Fenton of the Georgia Institute of Technology School of Physics suggests
26460-488: The prequel trilogy, some characters have lost faith in the Force, and the Galactic Empire hunts down surviving Jedi and other Force-sensitive characters. By the time of the events in The Force Awakens , some characters think the Jedi and the Force are myths. Some Force-sensitive characters derive special, psychic abilities from it, such as telekinesis , mind control , and extrasensory perception . The Force
26640-416: The protagonist on a quest. In her 1980 Washington Post review of The Empire Strikes Back , Judith Martin described the Force as "a mishmash of current cultic fashions without any base in ideas. It doesn't seem to be connected with ethics or a code of decent behavior, either." John Simon wrote in his 1977 review of Star Wars for New York magazine: And then there is that distressing thing called
26820-402: The rate of ATP production by the mitochondrion, and thus the availability of ATP to the cell. Acetyl-CoA, on the other hand, derived from pyruvate oxidation, or from the beta-oxidation of fatty acids , is the only fuel to enter the citric acid cycle. With each turn of the cycle one molecule of acetyl-CoA is consumed for every molecule of oxaloacetate present in the mitochondrial matrix, and
27000-455: The reactions are controlled by an electron transport chain, free electrons are not amongst the reactants or products in the three reactions shown and therefore do not affect the free energy released, which is used to pump protons (H ) into the intermembrane space. This process is efficient, but a small percentage of electrons may prematurely reduce oxygen, forming reactive oxygen species such as superoxide . This can cause oxidative stress in
27180-508: The relationship between yin and yang in Taoism , although the balance between yin and yang lacks the element of evil associated with the dark side. Taylor identifies other similarities between the Force and a Navajo prayer, prana , and qi . It is a common plot device in jidaigeki films like The Hidden Fortress (1958), which inspired Star Wars , for samurai who master qi to achieve astonishing feats of swordsmanship. Taylor added that
27360-459: The same pattern-recognition receptors (PRRs) that respond to pathogen-associated molecular patterns (PAMPs) during infections. For example, mitochondrial mtDNA resembles bacterial DNA due to its lack of CpG methylation and can be detected by Toll-like receptor 9 and cGAS . Double-stranded RNA (dsRNA), produced due to bidirectional mitochondrial transcription, can activate viral sensing pathways through RIG-I-like receptors . Additionally,
27540-995: The same name. Some cells in some multicellular organisms lack mitochondria (for example, mature mammalian red blood cells ). The multicellular animal Henneguya salminicola is known to have retained mitochondrion-related organelles despite a complete loss of their mitochondrial genome. A large number of unicellular organisms , such as microsporidia , parabasalids and diplomonads , have reduced or transformed their mitochondria into other structures, e.g. hydrogenosomes and mitosomes . The oxymonads Monocercomonoides , Streblomastix , and Blattamonas have completely lost their mitochondria. Mitochondria are commonly between 0.75 and 3 μm in cross section, but vary considerably in size and structure. Unless specifically stained , they are not visible. In addition to supplying cellular energy, mitochondria are involved in other tasks, such as signaling , cellular differentiation , and cell death , as well as maintaining control of
27720-448: The second film in the sequel trilogy, was released in 2017; Lucas described the film as "beautifully made". Lucas has had cursory involvement with Solo: A Star Wars Story (2018), the Star Wars streaming series The Mandalorian , and the premiere of the eighth season of Game of Thrones . Lucas met with J. J. Abrams before the latter began writing the script to the sequel trilogy's final film, The Rise of Skywalker , which
27900-427: The series would be a tragic one, examining Anakin Skywalker's fall to the dark side. Lucas also began to change the status of the prequels relative to the originals; at first, they were supposed to be a "filling-in" of history tangential to the originals, but now he saw that they could form the beginning of one long story that started with Anakin's childhood and ended with his death. This was the final step towards turning
28080-582: The series. Lucas was in attendance for a ceremony honoring Williams as the 44th recipient of the AFI Life Achievement Award , the first composer to receive the honor, and gave a speech in praise of their relationship and his work. In interviews, and most famously at the 40th Anniversary Star Wars Celebration convention, Lucas has repeatedly reaffirmed the importance of Williams to the Star Wars saga, affectionately referring to him as
28260-569: The sound and visual effects subdivisions of Lucasfilm, while Lucasfilm Games, later renamed LucasArts , produces products for the gaming industry. Having lost much of his fortune in a divorce settlement in 1987, Lucas was hesitant on making additional Star Wars features. However, the prequels , which were still only a series of ideas partially pulled from his original drafts of "The Star Wars", continued to tantalize him with technical possibilities that would make it worthwhile to revisit his older material. When Star Wars became popular once again, in
28440-458: The specific mechanisms between mitochondria and the cell cycle regulation is not well understood, studies have shown that low energy cell cycle checkpoints monitor the energy capability before committing to another round of cell division. Programmed cell death (PCD) is crucial for various physiological functions, including organ development and cellular homeostasis. It serves as an intrinsic mechanism to prevent malignant transformation and plays
28620-483: The story of Star Wars character Darth Vader in some ways, but concluded he was glad to be able to make his films the way he wanted to. Lucas collaborated with Jeff Nathanson as a writer of the 2008 film Indiana Jones and the Kingdom of the Crystal Skull , directed by Steven Spielberg. Similar to the Star Wars prequels, the reception was mixed with fans and critics alike. From 2008 to 2014, Lucas also served as
28800-542: The theatrical run of Return of the Jedi . At this point, Lucas had no desire to return to Star Wars , and had unofficially canceled the sequel trilogy . Lucas, formerly a member of Writers Guild of America West , left and maintained financial core status in 1981. Also in 1983, Lucas and Tomlinson Holman founded the audio company THX . The company was formerly owned by Lucasfilm and contains equipment for stereo, digital, and theatrical sound for films, and music. Skywalker Sound and Industrial Light & Magic , are
28980-417: The time, including Jean-Luc Godard 's Breathless , François Truffaut 's Jules et Jim and Federico Fellini 's 8½ . "That's when George really started exploring," Plummer said. Through his interest in autocross racing, Lucas met renowned cinematographer Haskell Wexler , another race enthusiast. Wexler, later to work with Lucas on several occasions, was impressed by Lucas's talent. "George had
29160-409: The tissue's energy needs (e.g., in muscle ) are suddenly increased by activity. In the citric acid cycle, all the intermediates (e.g. citrate , iso-citrate , alpha-ketoglutarate , succinate, fumarate , malate and oxaloacetate) are regenerated during each turn of the cycle. Adding more of any of these intermediates to the mitochondrion therefore means that the additional amount is retained within
29340-470: The wake of Dark Horse 's comic book line and Timothy Zahn 's trilogy of spin-off novels , Lucas realized that there was still a large audience. His children were older, and with the explosion of CGI technology he began to consider directing once again. By 1993, it was announced, in Variety among other sources, that Lucas would be making the prequels. He began penning more to the story, indicating that
29520-405: The writing process. Kurtz told Lucas he was unhappy with drafts in which the Force was connected with the Kyber Crystal, and he was also dissatisfied with the early Ashla and Bogan concepts. "The act of living generates a force field, an energy. That energy surrounds us; when we die, that energy joins with all the other energy. There is a giant mass of energy in the universe that has a good side and
29700-544: Was "very torn" about having sold the rights to the franchise, despite having hand-picked Abrams to direct, and that his father was "there to guide" but that "he wants to let it go and become its new generation." Among the materials turned over to the production team were story treatments Lucas developed when he considered creating Episodes VII – IX himself; in January 2015, Lucas stated that Disney had discarded his story ideas. The Force Awakens , directed by J. J. Abrams ,
29880-494: Was a critical success but a financial failure. His next work as a writer-director was American Graffiti (1973), inspired by his youth in early 1960s Modesto, California , and produced through the newly founded Lucasfilm. The film was critically and commercially successful and received five Academy Award nominations, including Best Director and Best Picture . Lucas's next film, the epic space opera Star Wars (1977), later retitled Star Wars: Episode IV – A New Hope , had
30060-607: Was composed by John Williams , on the recommendation of his friend and colleague Steven Spielberg. Whilst initially wanting to use tracks and film music in a similar manner to 2001: A Space Odyssey , which served as the inspiration for the film, Williams advised against this and instead proposed a system of recurring themes (or leitmotifs ) to enhance the story in the style of classical composers Gustav Holst , William Walton , and Igor Stravinsky ; works that Lucas had used as " temp tracks " for Williams to gain inspiration from. The film, and subsequent sequels and prequels, make use of
30240-897: Was considering establishing a museum, the Lucas Cultural Arts Museum, to be built on Crissy Field near the Golden Gate Bridge in San Francisco, which would display his collection of illustrations and pop art, with an estimated value of more than $ 1 billion. Lucas offered to pay the estimated $ 300 million cost of constructing the museum, and would endow it with $ 400 million when it opened, eventually adding an additional $ 400 million to its endowment. After being unable to reach an agreement with The Presidio Trust , Lucas turned to Chicago. A potential lakefront site on Museum Campus in Chicago
30420-440: Was controversial, with Evan Narcisse of Time writing that the concept ruined Star Wars for him and a generation of fans because "the mechanisms of the Force became less spiritual and more scientific". Film historian Daniel Dinello called midi-chlorians "anathema to Star Wars fanatics who thought they reduced the Force to a kind of viral infection." Referring to "midi-chlorians" became a screenwriting shorthand for over-explaining
30600-590: Was founded as a nonprofit operating foundation to celebrate and encourage innovation in schools. The foundation's content is available under the brand Edutopia , in an award-winning web site, social media and via documentary films. Lucas, through his foundation, was one of the leading proponents of the E-Rate program in the universal service fund , which was enacted as part of the Telecommunications Act of 1996 . On June 24, 2008, Lucas testified before
30780-612: Was founded in 1979 as the Graphics Group, one third of the Computer Division of Lucasfilm . Pixar's early computer graphics research resulted in a digital film The Adventures of André & Wally B. and groundbreaking effects in films such as Star Trek II: The Wrath of Khan and Young Sherlock Holmes , and the group was purchased in 1986 by Steve Jobs shortly after he left Apple Computer . Jobs paid Lucas $ 5 million and put $ 5 million as capital into
30960-494: Was involved in the production of, and financially benefited from, almost every big-budget film released in the U.S. from the late 1980s until the 2012 Disney sale. In addition to his career as a filmmaker, Lucas has founded and supported multiple philanthropic organizations and campaigns dedicated to education and the arts, including the George Lucas Educational Foundation , which has been noted as
31140-702: Was listed by the American Film Institute in 2005 as the greatest film score of all time . The professional relationship formed by Lucas and Williams extended through to Williams working on all of Lucas's blockbuster franchise movies: the remaining two films of the Star Wars original trilogy ; all three films of prequel trilogy developed over fifteen years later; and the five films of the Indiana Jones franchise, in which Williams reunited with his long-time collaborator Spielberg. In his collaborations with Lucas, Williams received six of his fifty-two Academy Award nominations ( Star Wars, The Empire Strikes Back, Return of
31320-503: Was no longer operational, Lucas approached Douglas Trumbull , best known for the effects on 2001: A Space Odyssey (1968) and Silent Running (1972). Trumbull declined as he was already committed to working on Steven Spielberg 's film Close Encounters of the Third Kind (1977), but suggested his assistant John Dykstra to Lucas. Dykstra brought together a small team of college students, artists, and engineers and set them up in
31500-418: Was only because Alan Ladd Jr. at 20th Century Fox liked American Graffiti that he forced through a production and distribution deal for the film, which ended up restoring Fox to financial stability after a number of flops. Star Wars was significantly influenced by samurai films of Akira Kurosawa , Spaghetti Westerns , as well as classic sword and sorcery fantasy stories. Star Wars quickly became
31680-577: Was proposed in May 2014. By June 2014, Chicago had been selected, pending approval of the Chicago Plan Commission , which was granted. The museum project was renamed the Lucas Museum of Narrative Art . On June 24, 2016, Lucas announced that he was abandoning his plans to locate the museum in Chicago, due to a lawsuit by a local preservation group, Friends of the Parks, and would instead build
31860-587: Was released in 2019. Lucas founded a film production company Lucasfilm in 1971, and incorporated as Lucasfilm Ltd. on September 12, 1977. In the mid-1970s, the company's offices were located on the Universal Studios Lot . Lucas founded the Star Wars Corporation, Inc. as a subsidiary to control various legal and financial aspects of Star Wars (1977), including copyright, and sequel and merchandising rights. It also produced
32040-399: Was released on December 18, 2015. Kathleen Kennedy produced the film and its sequels. The new sequel trilogy was jointly produced by Lucasfilm and The Walt Disney Company , which had acquired Lucasfilm in 2012. During an interview with talk show host and journalist Charlie Rose that aired on December 24, 2015, Lucas likened his decision to sell Lucasfilm to Disney to a divorce and outlined
32220-565: Was the Serbian montagist (and dean of the USC Film Department) Slavko Vorkapich , a film theoretician who made stunning montage sequences for Hollywood studio features at MGM , RKO , and Paramount . Vorkapich taught the autonomous nature of the cinematic art form, emphasizing the kinetic energy inherent in motion pictures. After graduating with a bachelor of fine arts in film in 1967, he tried joining
32400-519: Was ultimately never produced. Projects where Lucas was credited as executive producer and sometimes story writer in this period include Kurosawa's Kagemusha (1980), John Korty 's Twice Upon a Time (1983), Ewoks: Caravan of Courage (1984), Ewoks: Battle for Endor (1985), Mishima: A Life in Four Chapters (1985), Jim Henson 's Labyrinth (1986), Ron Howard 's Willow (1988), Don Bluth 's The Land Before Time (1988), and
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