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77-576: The lives of the Freak Brothers revolve around the procurement and enjoyment of recreational drugs , particularly marijuana . The comics present a critique of the establishment while satirizing the counterculture . Fat Freddy's Cat appears in many of the stories, spinning off his own cartoon strip (which appeared as part of the Freak Brothers comic page, in the manner of older comic strip double features) and later some full-length episodes. An animated TV series adaptation, The Freak Brothers ,

154-658: A Schedule I drug , i.e., having the relatively highest abuse potential and no accepted medical use. Most marijuana at that time came from Mexico, but in 1975 the Mexican government agreed to eradicate the crop by spraying it with the herbicide paraquat, raising fears of toxic side effects. Colombia then became the main supplier. The "zero tolerance" climate of the Reagan and Bush administrations (1981–1993) resulted in passage of strict laws and mandatory sentences for possession of marijuana . The " War on Drugs " thus brought with it

231-406: A sidequel , a portmanteau of "side" (as in side-by-side) and " sequel ", when it occurs in the same timeframe as the original, sometimes contacting with the main narrative at points. In Japanese , the word gaiden ( 外伝 , pronounced [ɡaideɴ] , lit. "outside legends") also refers to such contemporaneous spin-offs and is frequently translated as "side story". Sometimes even when

308-424: A characteristic euphoria at moderate doses. High dosages taken to induce recreational drug effects may lead to overdoses. Antihistamines are also consumed in combination with alcohol, particularly by youth who find it hard to obtain alcohol. The combination of the two drugs can cause intoxication with lower alcohol doses. Hallucinations and possibly delirium resembling the effects of Datura stramonium can result if

385-603: A co-evolutionary relationship with psychotropic plant substances that is millions of years old." The severity of impact and type of risks that come with recreational drug use vary widely with the drug in question and the amount being used. There are many factors in the environment and within the user that interact with each drug differently. Alcohol is sometimes considered one of the most dangerous recreational drugs. Alcoholic drinks , tobacco products and other nicotine -based products (e.g., electronic cigarettes ), and cannabis are regarded by various medical professionals as

462-399: A fair amount of defecation. Like Garfield (whom he predates) he is laid back, but in his personal habits and outlook he is more like the Freak Brothers. However he tends to regard the Freak Brothers with amused contempt, frequently expressed by defecating in inappropriate and inconvenient places, such as stereo headphones. Like Calvin of Calvin and Hobbes he has a fertile imagination. He

539-400: A key tool in the analysis of comics in translation. Almost all of the titles in the series have a title in words. Issues #0–7 and #12–13 are in black and white; issues #8–11 were produced in both color and black-and-white editions. Several compilation titles have been published that merge several of the original titles into one book. Recreational drug use Recreational drug use

616-448: A large role in the exposure to and availability of certain types of drugs and patterns of use. According to addiction researcher Martin A. Plant, some people go through a period of self-redefinition before initiating recreational drug use. They tend to view using drugs as part of a general lifestyle that involves belonging to a subculture that they associate with heightened status and the challenging of social norms. Plant states: "From

693-589: A live-action Fabulous Furry Freak Brothers film. Shelton received the bulk of the money, which enabled him to live part-time in Europe. Meanwhile, the Universal-produced Freak Brothers film never made it to the production stage. In 2006, the company Grass Roots Films began production on a feature-length clay animation film based on the series, called Grass Roots , co-produced by German distribution company X Filme. In 2013, work on

770-712: A long worldwide history of use within medicinal and religious traditions. They are used in shamanic forms of ritual healing and divination , in initiation rites , and in the religious rituals of syncretistic movements such as União do Vegetal , Santo Daime , Temple of the True Inner Light , and the Native American Church . When used in religious practice, psychedelic drugs, as well as other substances like tobacco , are referred to as entheogens . Hallucinogen-induced psychosis occurs when psychosis persists despite no longer being intoxicated with

847-616: A number of different pharmacological mechanisms, the most prominent of which include potentiation of GABA or opioid activity, and inhibition of adrenergic , histamine or acetylcholine activity. Some are also capable of inducing feelings of euphoria . The most widely used depressant by far is alcohol (i.e. ethanol ). Stimulants or "uppers", such as amphetamines or cocaine , which increase mental or physical function, have an opposite effect to depressants. Depressants, in particular alcohol, can precipitate psychosis . A 2019 systematic review and meta-analysis by Murrie et al. found that

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924-437: A particular route of administration . Many drugs can be consumed in more than one way. For example, marijuana can be swallowed like food or smoked, and cocaine can be "sniffed" in the nostrils, injected, or, with various modifications, smoked. Many drugs are taken through various routes. Intravenous route is the most efficient, but also one of the most dangerous. Nasal, rectal, inhalation and smoking are safer. The oral route

1001-533: A sense of belonging to a group, family and attachment issues, history of trauma, failure at school or work, socioeconomic stressors, peer pressure, juvenile delinquency, availability, historical factors, or socio-cultural influences. There has been no consensus on a single cause. Instead, experts tend to apply the biopsychosocial model . Any number of factors may influence an individual's drug use, as they are not mutually exclusive . Regardless of genetics, mental health, or traumatic experiences, social factors play

1078-750: A sense of energy and alertness), and hallucinogens (drugs that induce perceptual distortions such as hallucination ). In popular practice, recreational drug use is generally tolerated as a social behaviour, rather than perceived as the medical condition of self-medication . However, drug use and drug addiction are severely stigmatized everywhere in the world. Many people also use prescribed and controlled depressants such as opioids , opiates , and benzodiazepines . What controlled substances are considered generally unlawful to possess varies by country, but usually includes cannabis , cocaine , opioids , MDMA , amphetamine , methamphetamine , psychedelics , benzodiazepines , and barbiturates . As of 2015, it

1155-480: A series of The Fabulous Furry Freak Brothers compilations and later The Adventures of Fat Freddy's Cat , which ran for four small size issues in the 1970s. Fat Freddy's Comics and Stories ( one-shot , 1983) also included several stories about the Cat. The Adventures of Fat Freddy's Cat were reprinted and expanded (starting over from #1) in six comic book size issues in the 1980s. They included new longer stories about

1232-632: A shift from reliance on imported supplies to domestic cultivation, particularly in Hawaii and California . Beginning in 1982, the Drug Enforcement Administration turned increased attention to marijuana farms in the United States, and there was a shift to the indoor growing of plants specially developed for small size and high yield. After over a decade of decreasing use, marijuana smoking began an upward trend once more in

1309-437: A supporting or cameo role, at the least as a historical mention, in the new subseries. Spin-offs sometimes generate their own spin-offs, leaving the new show in its own series only vaguely connected to the original series - for example, the police procedural franchises of NCIS / JAG and CSI have both spun multiple shows, including multiple spin-offs from series and spin-offs from spin-offs. A spin-off may be called

1386-410: A threesome of freaks (similar to, but distinct from, hippies ) from San Francisco . Other recurring characters include: Fat Freddy's Cat is a fictional orange Tabby cat , nominally belonging to Fat Freddy. While the Cat is usually featured in a small ' topper ' strip below a Freak Brothers strip, he has had independent appearances and storylines of his own. His two running jokes are Fat Freddy

1463-525: Is a big part of Scarface: The World Is Yours ). In the Fallout video game franchise, drugs ("chems" in the game) can fill the role of any above mentioned. Drug trafficking , gang rivalries , and their related criminal underworld also play a big part in the Grand Theft Auto video game franchise. The following substances are commonly used recreationally: Drugs are often associated with

1540-767: Is also an inn in Olongapo , Philippines , called "The Fabulous Furry Freak Brothers Stagger Inn". At the Le Havre Normandy University , Claire Bowen analysed the timeless appeal and current relevance of the Freak Brothers comics in the American couter culture of the 1970s Chiara Polli at the University of Messina conducted semiotic studies of a selection of Italian translations of the Freak Brothers Comics, using isotopies as

1617-448: Is any narrative work derived from an already existing work that focuses on different aspects from the original work. One of the earliest spin-offs of the modern media era, if not the first, happened in 1941 when the supporting character Throckmorton P. Gildersleeve from the old time radio comedy show Fibber McGee and Molly became the star of his own program The Great Gildersleeve (1941–1957). A spin-off (also spelt spinoff )

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1694-479: Is apt to tell tall stories to his three "nephews". One storyline features him playing the role of "F. Frederick Skitty", an undercover agent sworn to stop the distribution of "Tee Hee Hee", a drug that turns people into homosexuals . Another story involves a scheme by Fat Freddy to replicate Dick Whittington 's success and sell the Cat to the (fictional) small, oil-rich nation of Pootweet to deal with mice. The New Zealand band Fat Freddy's Drop , whose debut album won

1771-533: Is defined as the degree to which a psychoactive drug has the potential to cause harm to the user and is measured in several ways, such as by addictiveness and the potential for physical harm. More objectively harmful drugs may be colloquially referred to as "hard drugs", and less harmful drugs as "soft drugs". The term "soft drug" is considered controversial by critics as it may imply the false belief that soft drugs cause lesser or insignificant harm. Responsible drug use advocates that users should not take drugs at

1848-475: Is derived from already existing works that focus on more details and different aspects from the original work (e.g. particular topics, characters or events), and includes books, radio programs , television programs , films, video games , or any narrative work in any medium. In genre fiction , the term parallels its usage in television; it is usually meant to indicate a substantial change in narrative viewpoint and activity from that (previous) storyline based on

1925-518: Is estimated that about 5% of people worldwide aged 15 to 65 (158 million to 351 million) had used controlled drugs at least once. Common recreational drugs include caffeine , commonly found in coffee , tea , soft drinks , and chocolate ; alcohol , commonly found in beer , wine , cocktails , and distilled spirits ; nicotine , commonly found in tobacco , tobacco-based products , and electronic cigarettes ; cannabis and hashish (with legality of possession varying inter/intra-nationally); and

2002-555: Is extensively decked out with arcana and other memorabilia relating to the Fabulous Furry Freak Brothers and Fat Freddy's Cat. The science fiction novel Scam Artists of the Galaxy (2020) contains a location named Fat Freddy's Restaurant with a supercilious mostly orange cat. This novel's sequel, Election Matters: Life on Universityworld (2022), sees the cat and one of its kittens appear. Fat Freddy's Cat

2079-446: Is one of the safest and most comfortable, but of little bioavailability . Depressants are psychoactive drugs that temporarily diminish the function or activity of a specific part of the body or mind. Colloquially, depressants are known as "downers", and users generally take them to feel more relaxed and less tense. Examples of these kinds of effects may include anxiolysis, sedation, and hypotension. Depressants are widely used throughout

2156-413: Is the use of one or more psychoactive drugs to induce an altered state of consciousness , either for pleasure or for some other casual purpose or pastime. When a psychoactive drug enters the user's body, it induces an intoxicating effect . Recreational drugs are commonly divided into three categories: depressants (drugs that induce a feeling of relaxation and calmness), stimulants (drugs that induce

2233-794: Is too lazy to name him, and he suffers neglect and abuse from the Brothers' lifestyle. Single line segments appeared in student newspapers in Australia in the 1970s. Fat Freddy's Cat first appeared in 1969 in underground newspapers as a character in The Fabulous Furry Freak Brothers strip. He soon gained his own small spin-off topper strip, in imitation of the early Krazy Kat strips below The Family Upstairs by George Herriman . Some full-size stories also featured Fat Freddy's Cat. Many of these strips have been collected in comic book form by Rip Off Press in

2310-452: Is voiced by Tiffany Haddish in the animated series The Freak Brothers , which debuted in 2020, and is commonly called Kitty by Fat Freddy. This version of the character is female and is capable of conversing directly with the Freaks whom she once again has a habit of insulting and belittling. She can apparently handle weed much better than them, though this did not prevent her from having

2387-677: The Imperial College London , who stated that studies showing benefits for "moderate" alcohol consumption in "some middle-aged men" lacked controls for the variable of what the subjects were drinking beforehand. Experts in the United Kingdom have suggested that some psychoactive drugs that may be causing less harm to fewer users (although they are also used less frequently in the first place) are cannabis, psilocybin mushrooms , LSD , and MDMA ; however, these drugs have risks and side effects of their own. Drug harmfulness

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2464-655: The Thomas Pynchon novel Inherent Vice , was based in part on Freewheelin' Franklin Freek: "[T]here's this documentary on Daniel Ellsberg , called The Most Dangerous Man in America . There's a great picture of a buddy of his who has this great set of glasses, a floppy hat and these mutton chops. I took a still frame from that and I sent it to [Phoenix], along with the omnibus collection of The Fabulous Furry Freak Brothers comic, by Gilbert Shelton—and that's probably

2541-435: The U.S. government . These stories invariably show politicians and their agents as corrupt , incompetent, or both. The theme of foreign travel is sometimes explored, most notably in the three-part Idiots Abroad series. It is common for the storylines to begin with an air of realism, but rapidly descend into comic pantomime . Classic Freak Brothers stories include: In 1978, the Fabulous Furry Freak Brothers appeared in

2618-667: The controlled substances listed as controlled drugs in the Single Convention on Narcotic Drugs (1961) and the Convention on Psychotropic Substances (1971) of the United Nations (UN). Since the early 2000s, the European Union (EU) has developed several comprehensive and multidisciplinary strategies as part of its drug policy in order to prevent the diffusion of recreational drug use and abuse among

2695-468: The "100 Greatest Comics of the Century." The UK newspaper The Guardian said of a 2003 reprint of the story that, "The graphic quality is, even in slightly muddy reproduction, astonishing. Depictions of various European cities recall Hergé in their accuracy and detail ... As for the subject matter, considering the dates of composition, it has hardly dated." The Freak Brothers are not siblings. They are

2772-508: The 2005 Gilles Peterson Worldwide Winners Award , were named after the comic. The band's debut single was recorded under the influence of LSD that had been printed with blotter art of Fat Freddy's Cat, and the band liked the name. The popular 8-bit computer game Jet Set Willy has a room named "We Must Perform a Quirkafleeg" in honour of this strip. Fat Freddy's Restaurant in Galway , Ireland, described as "Galway's favourite restaurant",

2849-547: The Cat. A seventh edition was released (in the US only) in 1993. After the demise of the underground newspaper, the Cat continued to appear in various comic books. His last appearance to date was in a 1990 strip reprinted in The Fabulous Furry Freak Brothers #12. The Cat is much smarter than Freddy, and while sharing many of his preoccupations such as drugs, food, sleep and sex, his stories also feature

2926-672: The European population and raise public awareness on the adverse effects of drugs among all member states of the European Union , as well as conjoined efforts with European law enforcement agencies, such as Europol and EMCDDA , in order to counter organized crime and illegal drug trade in Europe. Many researchers have explored the etiology of recreational drug use. Some of the most common theories are: genetics , personality type, psychological problems, self-medication, sex, age, depression, curiosity, boredom, rebelliousness,

3003-661: The FBI reported that between the years 1966 and 1968, the number of arrests for marijuana possession, which had been outlawed throughout the United States under Marijuana Tax Act of 1937 , had increased by 98%. Despite acknowledgement that drug use was greatly growing among America's youth during the late 1960s, surveys have suggested that only as much as 4% of the American population had ever smoked marijuana by 1969. By 1972, however, that number would increase to 12%. That number would then double by 1977. The Controlled Substances Act of 1970 classified marijuana along with heroin and LSD as

3080-503: The Fabulous Furry Freak Brothers , had its first printing in 1971 and has been continually in print ever since. A weekly Freak Brothers comic strip was syndicated by Rip Off Press to underground and student publications in the 1970s, along with the related strip Fat Freddy's Cat . In addition to those strips, new adventures appeared in magazines such as Playboy , High Times , and Rip Off Comix ; these too were collected in comic book form. Shelton continued to write and draw

3157-964: The US as acetaminophen), the nonsteroidal anti-inflammatory drugs (NSAIDs) such as the salicylates (e.g. aspirin ), and opioid drugs such as hydrocodone , codeine , heroin and oxycodone . Some further examples of the brand name prescription opiates and opioid analgesics that may be used recreationally include Vicodin, Lortab, Norco (hydrocodone), Avinza, Kapanol (morphine), Opana, Paramorphan (oxymorphone), Dilaudid, Palladone (hydromorphone), and OxyContin (oxycodone). The following are examples of tranquilizers ( GABAergics ): Stimulants, also known as "psychostimulants", induce euphoria with improvements in mental and physical function, such as enhanced alertness, wakefulness, and locomotion. Stimulants are also occasionally called "uppers". Depressants or "downers", which decrease mental or physical function, are in stark contrast to stimulants and are considered to be their functional opposites. Stimulants enhance

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3234-728: The United States and in other parts of the world. The Freak Brothers' first comic book appearance was in Feds 'n' Heads , self-published by Shelton in the spring of 1968 (and later re-issued in multiple printings by Berkeley's the Print Mint ). They also appeared in the first two issues of Jay Lynch 's Bijou Funnies . In 1969 Shelton and three friends from Texas founded Rip Off Press in San Francisco, which took over publication of all subsequent Freak Brothers comics. The first compilation of their adventures, The Collected Adventures of

3311-616: The United States during the late 1980s–early 1990s. In video games , for example, drugs are portrayed in a variety of ways: including power-ups ( cocaine gum replenishes stamina in Red Dead Redemption 2 ), obstacles to be avoided (such as the Fuzzies in Super Mario World 2: Yoshi's Island that distort the player's view when accidentally consumed), items to be bought and sold for in-game currency (coke dealing

3388-409: The above reasons, the use of medicinal scopolamine for recreational uses is also observed. Analgesics (also known as "painkillers") are used to relieve pain (achieve analgesia ). The word analgesic derives from Greek "αν-" ( an- , "without") and "άλγος" ( álgos , "pain"). Analgesic drugs act in various ways on the peripheral and central nervous systems; they include paracetamol (also known in

3465-406: The activities of the series' principal protagonist, and so is a shift to that action and overall narrative thread of some other protagonist, which now becomes the central or main thread (storyline) of the new subseries. The new protagonist generally appears first as a minor or supporting character in the main storyline within a given milieu and it is very common for the previous protagonist to have

3542-436: The activity of the central and peripheral nervous systems . Common effects may include increased alertness , awareness , wakefulness , endurance , productivity , and motivation , arousal , locomotion , heart rate , and blood pressure , and a diminished desire for food and sleep . Use of stimulants may cause the body to significantly reduce its production of endogenous compounds that fulfill similar functions. Once

3619-450: The body to allergens , such as the pollen released by grasses and trees. An allergic reaction causes release of histamine by the body. Other uses of antihistamines are to help with normal symptoms of insect stings even if there is no allergic reaction. Their recreational appeal exists mainly due to their anticholinergic properties, that induce anxiolysis and, in some cases such as diphenhydramine , chlorpheniramine , and orphenadrine ,

3696-513: The cat respectively. Courtney Solomon and Mark Canton serve as executive producers, with Jeffrey Scott Edell serving as Co-Executive Producer, alongside Adam DeVine and Blake Anderson who also provide voice acting. The series is animated by Pure Imagination Studios and Starburns Industries studio, which also worked on Rick and Morty . In May 2022, the series was renewed for a second season. The series will be released on digital on April 17, 2023 by Lionsgate . Fat Freddy's Drop , formed in

3773-466: The consequences of irresponsible drug use to users. Another issue is that the illegality of drugs causes social and economic consequences for users—the drugs may be "cut" with adulterants and the purity varies wildly, making overdoses more likely—and legalization of drug production and distribution could reduce these and other dangers of illegal drug use. In efforts to curtail recreational drug use, governments worldwide introduced several laws prohibiting

3850-639: The consumption of club drugs is highly associated with the presence of criminal behaviors and recent alcohol abuse or dependence . The prevalence of recreational drugs in human societies is widely reflected in fiction, entertainment, and the arts, subject to prevailing laws and social conventions. For instance, in the music industry , the musical genres hip hop , hardcore rap , and trap , alongside their derivative subgenres and subcultures , are most notorious for having continuously celebrated and promoted drug trafficking , gangster lifestyle , and consumption of alcohol and other drugs since their inception in

3927-414: The drug is taken in much higher than therapeutic doses. Antihistamines are widely available over the counter at drug stores (without a prescription), in the form of allergy medication and some cough medicines . They are sometimes used in combination with other substances such as alcohol. The most common unsupervised use of antihistamines in terms of volume and percentage of the total is perhaps in parallel to

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4004-632: The drug. It is estimated that 26% of people with hallucinogen-induced psychosis will transition to a diagnosis of schizophrenia. This percentage is less than the psychosis transition rate for cannabis (34%) but higher than that of amphetamines (22%). Starting in the mid-20th century, psychedelic drugs have been the object of extensive attention in the Western world. They have been and are being explored as potential therapeutic agents in treating depression , post-traumatic stress disorder , obsessive–compulsive disorder , alcoholism , and opioid addiction . Yet

4081-581: The early 1990s, especially among teenagers, but by the end of the decade this upswing had leveled off well below former peaks of use. Many movements and organizations are advocating for or against the liberalization of the use of recreational drugs , most notably regarding the legalization of marijuana and cannabinoids for medical and/or recreational use. Subcultures have emerged among users of recreational drugs, as well as alternative lifestyles and social movements among those who abstain from them, such as teetotalism and " straight edge ". Since

4158-498: The early 2000s, medical professionals have acknowledged and addressed the problem of the increasing consumption of alcoholic drinks and club drugs (such as MDMA , cocaine , rohypnol , GHB , ketamine , PCP , LSD , and methamphetamine ) associated with rave culture among adolescents and young adults in the Western world . Studies have shown that adolescents are more likely than young adults to use multiple drugs , and

4235-1022: The effect of the ingested stimulant has worn off the user may feel depressed, lethargic, confused, and dysphoric. This is colloquially termed a "crash" and may promote reuse of the stimulant. Amphetamines are a significant cause of drug-induced psychosis. Importantly, a 2019 meta-analysis found that 22% of people with amphetamine-induced psychosis transition to a later diagnosis of schizophrenia. Examples of stimulants include: Hallucinogens can be divided into three broad categories: psychedelics , dissociatives , and deliriants . They can cause subjective changes in perception , thought , emotion and consciousness . Unlike other psychoactive drugs such as stimulants and opioids , hallucinogens do not merely amplify familiar states of mind but also induce experiences that differ from those of ordinary consciousness, often compared to non-ordinary forms of consciousness such as trance , meditation , conversion experiences, and dreams . Psychedelics, dissociatives, and deliriants have

4312-418: The film stopped. An animated television series adaptation titled The Freak Brothers , based on the characters and set in modern San Francisco, was released on Tubi on November 14, 2021. The series was preceded on May 6, 2020, by a mini-episode titled "Kentucky Fried Freaks". The series features Woody Harrelson , Pete Davidson , John Goodman , and Tiffany Haddish as voice actors for the three Freaks and

4389-464: The full-length pornographic film Up in Flames . The story involves the brothers' attempts to raise cash to make their rent deadline (the trio being in danger of being evicted from their apartment). Fat Freddy gains employment at a local food store run by graphic artist Robert Crumb 's character Mr. Natural . In 1979, Universal Studios paid Shelton and Rip Off Press $ 250,000 for the rights to make

4466-459: The function of endogenous neurotransmitters may have improved survival rates, conferring an evolutionary advantage. A typically restrictive prehistoric diet may have emphasized the apparent benefit of consuming psychoactive drugs , which had themselves evolved to imitate neurotransmitters. Chemical–ecological adaptations and the genetics of hepatic enzymes , particularly cytochrome P450 , have led researchers to propose that "humans have shared

4543-890: The harmful effects of the solvents or gases, or due to other chemicals used in the products inhaled. As with any recreational drug, users can be injured due to dangerous behavior while they are intoxicated, such as driving under the influence. Computer cleaning dusters are dangerous to inhale, because the gases expand and cool rapidly upon being sprayed. In many cases, users have died from hypoxia (lack of oxygen), pneumonia, cardiac failure or arrest, or aspiration of vomit. Examples include: Plants: Substances (also not necessarily psychoactive plants smoked within them): Minimally psychoactive plants which contain mainly caffeine and theobromine : Most known psychoactive plants: Solanaceae plants—contain atropine , hyoscyamine , and scopolamine : Cacti with mescaline : Other plants: Fungi: Spin-off (media) A spinoff or spin-off

4620-732: The late 1990s, is a Wellington , New Zealand , band that took its name from the Freak Brothers comics. According to the band, individual doses of a certain type of LSD popular in Wellington at that time had the image of Fat Freddy's Cat printed on it. Dropping — common slang for taking LSD — Fat Freddies became the inspiration for the band's name. Director Paul Thomas Anderson said the look of Joaquin Phoenix 's lead character, Larry "Doc" Sportello, in Anderson's 2014 adaptation of

4697-460: The list. In one adventure, Franklin is shown to turn down an offer of "smack" when hitching a ride. Food is a recurring subject. These stories most often involve Fat Freddy and his marijuana-induced "munchies" (increased appetite). The squalor engendered by the Brothers' indolence is often highlighted; several strips feature the household's cockroach population, ruled over by a fascist monarchy . Several stories satirize governments , particularly

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4774-999: The lungs. While some "inhalant" drugs are used for medical purposes , as in the case of nitrous oxide , a dental anesthetic, inhalants are used as recreational drugs for their intoxicating effect. Most inhalant drugs that are used non-medically are ingredients in household or industrial chemical products that are not intended to be concentrated and inhaled, including organic solvents (found in cleaning products, fast-drying glues, and nail polish removers), fuels ( gasoline (petrol) and kerosene ), and propellant gases such as Freon and compressed hydrofluorocarbons that are used in aerosol cans such as hairspray, whipped cream, and non-stick cooking spray. A small number of recreational inhalant drugs are pharmaceutical products that are used illicitly, such as anesthetics ( ether and nitrous oxide) and volatile anti- angina drugs ( alkyl nitrites , more commonly known as "poppers"). The most serious inhalant abuse occurs among children and teens who "[...] live on

4851-423: The medicinal use of some antihistamines to extend and intensify the effects of opioids and depressants. The most commonly used are hydroxyzine , mainly to extend a supply of other drugs, as in medical use, and the above-mentioned ethanolamine and alkylamine-class first-generation antihistamines, which are – once again as in the 1950s – the subject of medical research into their anti-depressant properties. For all of

4928-430: The mid-19th century to the 1930s, American physicians prescribed Cannabis sativa as a prescription drug for various medical conditions. In the 1960s, the counterculture movement introduced the use of psychoactive drugs, including cannabis. Young adults and college students reported the recreational prevalence of cannabis, among other drugs, at 20-25% while the cultural mindset of using was open and curious. In 1969,

5005-779: The most common and widespread gateway drugs . In the United States , Australia , and New Zealand , the general onset of drinking alcohol , tobacco smoking , cannabis smoking , and consumption of multiple drugs most frequently occurs during adolescence and in middle school and secondary school settings. Some scientific studies in the early 21st century found that a low to moderate level of alcohol consumption, particularly of red wine , might have substantial health benefits such as decreased risk of cardiovascular diseases , stroke , and cognitive decline . This claim has been disputed, specifically by British researcher David Nutt , professor of neuropsychopharmacology at

5082-539: The most commonly used method for drug use education; however, the success rates of these intervention programs are highly dependent on the commitment of participants and are limited in general. Alcohol is the most widely used recreational drug in Australia . 86.2% of Australians aged 12 years and over have consumed alcohol at least once in their lifetime, compared to 34.8% of Australians aged 12 years and over who have used cannabis at least once in their lifetime. From

5159-531: The most popular, and at the same time most stigmatized, use of psychedelics in Western culture has been associated with the search for direct religious experience , enhanced creativity , personal development, and "mind expansion". The use of psychedelic drugs was a major element of the 1960s counterculture , where it became associated with various social movements and a general atmosphere of rebellion and strife between generations. Inhalants are gases , aerosols , or solvents that are breathed in and absorbed through

5236-523: The most we really talked about [Phoenix's portrayal of the character]". The ultra supporters of Serie B Italian football (soccer) team Ternana Calcio , from the Italian Umbrian city of Terni are called "The Freak Brothers". Like many Italians ultras, they are linked with the political left. Fat Freddy's Restaurant, in Galway , Ireland, has arcana and other memorabilia relating to the Fabulous Furry Freak Brothers and Fat Freddy's Cat. There

5313-460: The possession of almost all varieties of recreational drugs during the 20th century. The " War on Drugs " promoted by the United States, however, is now facing increasing criticism. Evidence is insufficient to tell if behavioral interventions help prevent recreational drug use in children. One in four adolescents has used an illegal drug, and one in ten of those adolescents who need addiction treatment get some type of care. School-based programs are

5390-504: The rate of transition from opioid, alcohol and sedative induced psychosis to schizophrenia was 12%, 10% and 9% respectively. Antihistamines (or "histamine antagonists") inhibit the release or action of histamine . "Antihistamine" can be used to describe any histamine antagonist, but the term is usually reserved for the classical antihistamines that act upon the H 1 histamine receptor . Antihistamines are used as treatment for allergies . Allergies are caused by an excessive response of

5467-399: The same time as activities such as driving, swimming, operating machinery, or other activities that are unsafe without a sober state. Responsible drug use is emphasized as a primary prevention technique in harm-reduction drug policies. Harm-reduction policies were popularized in the late 1980s, although they began in the 1970s counter-culture, through cartoons explaining responsible drug use and

5544-438: The series until 1992, in collaboration with Dave Sheridan (1974 – 1982) and Paul Mavrides (1978 – 1992). The majority of the comic books consist of one or more multi-page stories together with a number of one-page strips; many of the latter have a one-row skit featuring Fat Freddy's Cat at the bottom of the page. Issues #8-10 contained only the long-form story "The Idiots Abroad", which The Comics Journal listed as #44 of

5621-401: The streets completely without family ties". Inhalant users inhale vapor or aerosol propellant gases using plastic bags held over the mouth or by breathing from a solvent-soaked rag or an open container. The effects of inhalants range from an alcohol-like intoxication and intense euphoria to vivid hallucinations , depending on the substance and the dosage. Some inhalant users are injured due to

5698-406: The ultimate high that sent them from 1969 to 2020. Drug use is the predominant theme that runs throughout all volumes of this title. The protagonists "live in a state of blissful torpor relieved only by bursts of paranoia or stimulant-induced frenzy." Marijuana is the most frequently mentioned, but numerous other stimulants and hallucinogens are mentioned as well. Heroin is usually missing from

5775-506: The user's point of view there are many positive reasons to become part of the milieu of drug taking. The reasons for drug use appear to have as much to do with needs for friendship, pleasure and status as they do with unhappiness or poverty. Becoming a drug taker, to many people, is a positive affirmation rather than a negative experience". Anthropological research has suggested that humans "may have evolved to counter-exploit plant neurotoxins ". The ability to use botanical chemicals to serve

5852-411: The world as prescription medicines and as illicit substances . When these are used, effects may include anxiolysis (reduction of anxiety), analgesia (pain relief), sedation , somnolence , cognitive/memory impairment, dissociation , muscle relaxation, lowered blood pressure / heart rate , respiratory depression , anesthesia , and anticonvulsant effects. Depressants exert their effects through

5929-732: Was released on Tubi on November 14, 2021. The Freak Brothers first appeared in The Rag , an underground newspaper published in Austin, Texas, beginning in May 1968. Their debut was in an advertising flyer for a winter 1968 film short called The Texas Hippies March on the Capitol . Freak Brothers strips soon became popular and, thanks to the Underground Press Syndicate , were regularly reprinted in underground papers around

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