128-549: The University of Liverpool (abbreviated UOL ) is the "original red brick " research university situated in Liverpool , England. Founded in 1881 as University College Liverpool, Victoria University , it gained independence by Royal Charter in 1903 attaining the decree to award degrees. The university owns and operates some of the nation's historical and cultural assets, such as the Victoria Gallery & Museum ,
256-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether
384-403: A skin rash . Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through
512-427: A University of Liverpool degree as well as a degree from XJTLU. The teaching language is English. The university offers a wide selection of accommodation that are on campus as well as student villages off campus. As part of a £660 million investment in campus facilities and student experience, the university has built 3 new on campus halls, while refurbishing existing accommodation. The accommodation offered currently by
640-598: A broad range of teaching and research in both arts and sciences, and the University of Liverpool School of Medicine established in 1835 is today one of the largest medical schools in the UK. It also has strong links to the neighbouring Royal Liverpool University Hospital . The university has a students' union to represent students' interests, known as the Liverpool Guild of Students . The university previously had
768-729: A catered or self-catering basis. The centrepiece of the campus remains the university's original red brick building, the Victoria Building. Opened in 1892, it has recently been restored as the Victoria Gallery and Museum, complete with cafe and activities for school visits. In 2011 the university made a commitment to invest £660m into the 'Student Experience', £250m of which will reportedly be spent on Student Accommodation. Announced so far have been two large On-Campus halls of residences (the first of which, Vine Court, opened September 2012), new Veterinary Science facilities, and
896-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but
1024-474: A college of science established, in partnership with Durham, in 1871. Reading was established as an extension college by the University of Oxford in 1892, incorporating pre-existing schools of art and science, while Nottingham was established as a civic college in 1881 and students were awarded degrees by the University of London until it received its Royal Charter in 1948. Combined English Universities
1152-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox
1280-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major
1408-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in
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#17327866016591536-582: A large atrium and houses seven separate laboratories that can accommodate 1,600 students at a time. A flexible teaching space, computing centre, multi-departmental teaching spaces and communal work spaces can also be found inside. The adjoining University Lecture Block building contains four lecture rooms and further social spaces. In 2008 the University of Liverpool was voted joint seventeenth greenest university in Britain by WWF supported company Green League. This represents an improvement after finishing 55th in
1664-577: A less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash) was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox,
1792-638: A mixture of Wake-on-LAN and commercial power management software. The university is ranked in the top 1% of universities worldwide according to Academic ranking of world universities and has previously been ranked within the top 150 university globally by the guide. It is also a founding member of the Russell Group and a founding member of the Northern Consortium . The university is a research-based university with 33,000 students pursuing over 450 programmes spanning 54 subject areas. It has
1920-650: A pay rise of 1% which unions equated to a 13% pay cut since 2008. The strikes were supported by both the university's Guild of Students and the National Union of Students . Some students at the university supported the strike, occupying buildings on campus. The university is mainly based around a single urban campus approximately five minutes' walk from Liverpool City Centre, at the top of Brownlow Hill and Mount Pleasant. Occupying 100 acres, it contains 192 non-residential buildings that house 69 lecture theatres, 114 teaching areas and research facilities. The main site
2048-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on
2176-553: A range of subjects. The university was the first in the UK to establish departments in oceanography , civic design , architecture , and biochemistry (at the Johnston Laboratories ). It was also the first UK university to establish an independent university campus in China, known as Xi'an Jiaotong-Liverpool University . The Interdisciplinary Centre for Sustainability Research (ICSR) was established in 2024 to tackle
2304-579: A recently refurbished Lecture Theatre Block (LTB) and teaching facilities (Central Teaching Labs, CTL) for the Departments of Chemistry and Physics and the School of Environmental Sciences, within the university's Central City Centre Campus. It was completed and officially opened in September 2012 with an estimated project cost of £23m. The main building, the 'Central Teaching Laboratory', is built around
2432-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with
2560-419: A result, it meets the dictionary definition of a red brick university, and is sometimes named as such. Department for Education research in 2016 split universities into four categories: ancient (pre-1800), red brick (1800–1960), plate glass (1960-1992), and post-1992 . Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to
2688-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into
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#17327866016592816-400: A strategic partnership with Laureate International Universities , a for-profit college collective, for University of Liverpool online degrees. In 2019, the university announced a new partnership with Kaplan Open Learning for delivery of their online degrees. The figurehead of the university is the chancellor . The following have served in that role: The professional head of the university
2944-523: A £10m refurbishment of the Liverpool Guild of Students . New Central Teaching Laboratories for physics, earth sciences, chemistry and archaeology were opened in autumn 2012. In 2013, the University of Liverpool opened a satellite campus in Finsbury Square in London , offering a range of professionally focussed masters programmes. The Central Teaching Hub is a large multi-use building that houses
3072-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox
3200-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond
3328-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during
3456-405: Is an inter-university competition between Liverpool, Leeds and Manchester. The Varsity Cup is a popular "derby" event between Liverpool John Moores University and the University of Liverpool. There have been ten Nobel Prize Laureates who have been based at the university during a significant point in their career. Red brick university A red brick university (or redbrick university )
3584-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through
3712-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade
3840-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope
3968-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c. 1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in
University of Liverpool - Misplaced Pages Continue
4096-552: Is divided into three faculties: Health and Life Sciences; Humanities and Social Sciences; and Science and Engineering. The Veterinary Teaching Hospital (Leahurst) and Ness Botanical Gardens are based on the Wirral Peninsula . There was formerly a marine biology research station at Port Erin on the Isle of Man until it closed in 2006. Fifty-one residential buildings, on or near the campus, provide 3,385 rooms for students, on
4224-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had
4352-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in
4480-632: Is situated in Suzhou Industrial Park in the eastern part of Suzhou in the province of Jiangsu , 90 km west of Shanghai. It is a science and engineering university with a second focus in English, recognised by the Chinese Ministry of Education as a "not for profit" educational institution. The university offers undergraduate degree programmes in the fields of Science, Engineering, and Management. Students are rewarded with
4608-655: Is the vice-chancellor . The following have served in that role: Since 2009, teaching departments of the university have been divided into three faculties: Science and Engineering, Health and Life Sciences, and Humanities and Social Sciences. Each faculty is headed by an Executive Pro-Vice-Chancellor, who is responsible for all schools in the faculty. Faculty of Health & Life Sciences Faculty of Humanities & Social Sciences Faculty of Science & Engineering In terms of average UCAS points of entrants, Liverpool ranked 40th in Britain in 2014. The university gives offers of admission to 83.1% of its applicants,
4736-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this
4864-698: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where
4992-475: The Humboldt University of Berlin , which emphasised practical knowledge over the academic sort. This distinguished the red brick universities from the ancient English universities of Oxford and Cambridge and from the newer (although still pre-Victorian) University of Durham , collegiate institutions which concentrated on divinity and the liberal arts, and imposed religious tests (e.g. assent to
5120-569: The Mason Science College (opened two years before University College Liverpool in 1880), an elaborate red brick and terracotta building in central Birmingham which was demolished in 1962. These universities were distinguished by being non- collegiate institutions that admitted men without reference to religion or background and concentrated on imparting to their students "real-world" skills, often linked to engineering and medicine. In this sense they owed their structural heritage to
5248-645: The N8 Group in 2004. In the 21st century physicists, engineers and technicians from the University of Liverpool were involved in the construction of the Large Hadron Collider at CERN , working on two of the four detectors in the LHC. In 2004, Sylvan Learning, later known as Laureate International Universities, became the worldwide partner for University of Liverpool online. In 2019, it was announced that Kaplan Open Learning, part of Kaplan, Inc , would be
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5376-521: The N8 Group . As of 2024, the university holds four academic fellows of the Academy of Social Sciences and one of the British Academy . Among its alumni and faculty are 10 Nobel prize laureates , with notable alumni leading fields in medicine , law , business , engineering , arts , politics , and technology . Liverpool is consistently ranked among the top 1% of global universities for
5504-676: The Ness Botanic Gardens , the Liverpool Royal Infirmary , and the more recent, Yoko Ono Lennon Centre . Organised by three faculties divided into 35 schools and departments, the university offers more than 230 first degree courses across 103 subjects. It is a founding member of the leading research-intensive association of British universities, the Russell Group , and in Northern England ,
5632-568: The Thirty-Nine Articles ) on staff and students. Scotland's ancient universities ( St Andrews , Glasgow , Aberdeen and Edinburgh ) were founded on a different basis between 1400 and 1600. The first wave of large civic red brick universities all gained official university status before the First World War: all of these institutions have origins dating back to older medical or engineering colleges, and were located in
5760-516: The United Nations Sustainable Development Goals (SDGs) . As of 2023, Liverpool withheld total net assets of £1.169 billion, with a turnover of £675.1 million, including £118 million from research grants and contracts, the ninth-largest endowment among all universities in the UK. Graduates of the university are styled with the post-nominal letters , Lpool , to indicate the institution. The university
5888-624: The University of Dundee (originally an independent university college, before becoming a constituent college of the University of St Andrews), Newcastle University (previously a college of the University of Durham, and noted by Truscot as "perhaps" being included), and the Welsh university colleges (not named, but could include Aberystwyth (1872), Cardiff (1883), Bangor (1885) and Swansea (1920)). Notably, Whyte does not include Reading or Nottingham, which Truscot lists in his second edition. Many other institutions share similar characteristics to
6016-403: The University of London . Following a royal charter and act of Parliament in 1903, it became an independent university (the University of Liverpool) with the right to confer its own degrees. The next few years saw major developments at the university, including Sir Charles Sherrington 's discovery of the synapse and William Blair-Bell's work on chemotherapy in the treatment of cancer. In
6144-463: The University of Oxford and the only university to receive its charter between the two world wars, describes itself as a "red brick" university. Queen's University Belfast gained university status in 1908 during the same period as the English red brick universities, having previously been established in 1845 as a college of the Queen's University of Ireland (later Royal University of Ireland ). As
6272-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that
6400-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of
6528-564: The smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after the disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It
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#17327866016596656-456: The "red brick" university alluded to in Peers' book, receiving university status in 1903, the University of Birmingham was the first of the civic universities to gain independent university status in 1900 and the university has stated that the popularity of the term "red brick" owes much to its own Chancellor's Court, constructed from Accrington red brick . The University of Birmingham grew from
6784-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses
6912-459: The 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated, the other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which
7040-408: The 1930s to 1940s Sir James Chadwick and Sir Joseph Rotblat made major contributions to the development of the atomic bomb . From 1943 to 1966 Allan Downie , Professor of Bacteriology, was involved in the eradication of smallpox . In 1994 the university was a founding member of the Russell Group , a collaboration of twenty leading research-intensive universities, as well as a founding member of
7168-571: The 7th highest amongst the Russell Group . According to the 2017 Times and Sunday Times Good University Guide, approximately 12% of Liverpool's undergraduates come from independent schools. In the 2016–17 academic year, the university had a domicile breakdown of 72:3:25 of UK:EU:non-EU students respectively with a female to male ratio of 55:45. In the Complete University Guide 2013, published in The Independent ,
7296-779: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,
7424-452: The Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and the malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and
7552-539: The Second World War (with the exception of Reading) rather than before the First World War. The Robbins Report lists University of Reading , University of Southampton , University of Hull , University of Exeter , University of Leicester and Keele University as being "younger civic universities". Of these, the University of Reading , founded in the late 19th century as an extension college of
7680-833: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,
7808-565: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor
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#17327866016597936-551: The University of Liverpool was ranked 31st out of 124, based on nine measures, while The Times Good University Guide 2008 ranked Liverpool 34th out of 113 universities. The Sunday Times university guide recently ranked the University of Liverpool 27th out of 123. In 2010, The Sunday Times has ranked University of Liverpool 29th of 122 institutions nationwide. In 2008 the THE-QS World University Rankings rated University of Liverpool 99th best in
8064-422: The University of Liverpool with a University College in 1881, and the University of Sheffield with a medical school in 1828, Firth College in 1879 and a technical school in 1884, which merged to form a university college in 1897. Of the redbricks that gained independent university status later, Newcastle owed its beginnings to a medical school established in 1834 and affiliated to Durham University from 1852, and
8192-406: The University of Liverpool's reputation for internationally outstanding research. Chemistry, Computer Science, General Engineering, Archaeology, Agriculture, Veterinary & Food Science, Architecture, Clinical Medicine, and English, are ranked in the top 10 in the UK for research excellence rated as 4* (world-leading) or 3* (internationally excellent), and also performed particularly well in terms of
8320-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add
8448-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing
8576-501: The basis of the Manchester Institute of Science and Technology (UMIST), and thus led towards the current University of Manchester formed in 2004. The University of Birmingham has origins dating back to the 1825 Birmingham Medical School . The University of Leeds also owes its foundations to a medical school: the 1831 Leeds School of Medicine . The University of Bristol began with the 1876 University College, Bristol ,
8704-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When
8832-424: The case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form, the prodromal illness still occurred but may have been less severe than in
8960-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate
9088-405: The civic universities, while using the pseudonym "Bruce Truscot" in his 1943 book Redbrick University . Although Peers used red brick in the title of the original book, he used redbrick adjectivally in the text and in the title of the 1945 sequel. He is said to have later regretted his use of red brick in the title. The term red brick for this category of universities is used as a contrast to
9216-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized
9344-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as
9472-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly
9600-400: The distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach the outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series,
9728-435: The first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by the second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By
9856-423: The first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and the temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on
9984-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to
10112-478: The genus Orthopoxvirus . The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and
10240-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox
10368-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,
10496-408: The impact of their research. The Computer Science department was ranked 1st in UK for 4* and 3* research, with 97% of the research being rated as world-leading or internationally excellent – the highest proportion of any computer science department in the UK. The Chemistry department was also ranked 1st in the UK with 99% of its research rated as 4* world leading or 3* internationally excellent In 2006
10624-462: The industrial centres of the late Victorian and Edwardian eras that required strong scientific and technical workforces. These universities developed out of various 19th-century private research and education institutes in industrial cities known as university colleges , and presented their students for external examinations of the University of London or were part of the federal Victoria University . The 1824 Manchester Mechanics' Institute formed
10752-464: The last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred a year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of
10880-659: The league table the previous year. The position of the university is determined by point allocation in departments such as Transport, Waste management, sustainable procurement and Emissions among other categories; these are then transpired into various awards. Liverpool was awarded the highest achievement possible in Environmental policy, Environmental staff, Environmental audit, Fair trade status, Ethical investment policy and Waste recycled while also scoring points in Carbon emissions, Water recycle and Energy source. Liverpool
11008-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after
11136-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in
11264-407: The main building for University College, Liverpool) is built from a distinctive red pressed brick, with terracotta decorative dressings. On this basis the University of Liverpool claims to be the original "red brick" institution, although the titular, fictional Redbrick University was a cipher for all the civic universities of the day. While the University of Liverpool was an inspiration for
11392-452: The malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and the common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15,
11520-692: The new partner for the University of Liverpool's online programmes. Laureate continued to provide some teaching provision for existing students until 2021. The university has produced ten Nobel Prize winners, from the fields of science, medicine, economics and peace . The Nobel laureates include the physician Sir Ronald Ross , physicist Charles Barkla , physicist Martin Lewis Perl , the physiologist Sir Charles Sherrington , physicist Sir James Chadwick , chemist Sir Robert Robinson , chemist Har Gobind Khorana , physiologist Rodney Porter , economist Ronald Coase and physicist Joseph Rotblat . Sir Ronald Ross
11648-513: The older more established universities that were all stone masonry constructions. The use of bricks was seen as a cheaper and less traditional alternative and therefore not as highly regarded, reflected in the general view of these new universities compared to the established ones. Peers's reference was inspired by the fact that the Victoria Building at the University of Liverpool (designed by Alfred Waterhouse and completed in 1892 as
11776-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox
11904-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox
12032-416: The ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)
12160-445: The original civic universities, namely those in the second wave of civic universities before the advent of the plate glass universities in 1961. These universities were similar to the red bricks in that they evolved from local university colleges and (with the exception of Keele) awarded external degrees of the University of London before being granted full university status; they differ in that they became universities later, after
12288-413: The original redbrick institutions, or their predecessor institutes, gained university status before World War I and were initially established as civic science or engineering colleges. Eight of the nine original institutions are members of the Russell Group . The term red brick or redbrick was coined by Edgar Allison Peers , a professor of Spanish at the University of Liverpool , to describe
12416-588: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of
12544-497: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because
12672-416: The pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced a discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on
12800-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before
12928-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this
13056-405: The sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to the touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week,
13184-481: The skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to the whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on
13312-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There
13440-553: The sports have both male and female teams and most are involved in competition on a national scale. BUCS is the body which organises national university competitions involving 154 institutions in 47 sports. Most sports involve travelling to various locations across the country, mainly on Wednesday afternoons. Two other prominent competitions are the Christie Championships and the Varsity Cup. The Christie Cup
13568-516: The universities around the world by SCImago Institutions Rankings . In the 2021 Research Excellence Framework (REF), which assesses the quality of research in UK higher education institutions, Liverpool is ranked joint 25th by GPA (along with Durham University and the University of Nottingham ) and 19th for research power (the grade point average score of a university, multiplied by the full-time equivalent number of researchers submitted). The Research Excellence Framework for 2014 has confirmed
13696-408: The university became the first in the UK to establish an independent university in China, making it the world's first Sino-British university. Resulting from a partnership between the University of Liverpool and Xi'an Jiaotong University , Xi'an Jiaotong-Liverpool University is the first Sino-British university between research-led universities, exploring new educational models for China. The campus
13824-532: The university for 2019/2020 academic year are listed below: Greenbank Student Village In 2018, the university faced strong criticism from the student body that the university provided halls were too expensive, by the Cut the Rent campaign. Privately accommodation owned Apollo Court ranked 3rd and Myrtle Court ranked 4th in the UK for value for money on a university review platform StudentCrowd. In 2021 "Gladstone Halls"
13952-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on
14080-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox
14208-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in
14336-640: The world, and 137th best worldwide in 2009. In 2011 the QS World University Rankings ranked the university in 123rd place, up 14. In the Times Good University Guide 2013, the University of Liverpool was ranked 29th. Liverpool is ranked 122nd in the world (and 15th in the UK) in the 2016 Round University Ranking . The 2018 U.S. News & World Report ranks Liverpool 129th in the world. In 2019, it ranked 178th among
14464-617: Was a university constituency in the UK Parliament created by the Representation of the People Act 1918 for graduates of Durham University and the six pre-World War One red bricks (Birmingham, Bristol, Leeds, Liverpool, Manchester, and Sheffield). Graduates of Oxford , Cambridge , and London had already been enfranchised and graduates of the University of Wales were enfranchised at the same time. Reading University
14592-537: Was added to the Combined English Universities constituency in 1928 (prior to this its graduates, taking London degrees, would have joined the London constituency). The constituency was abolished in 1950. Various other civic institutions with origins dating from the 19th and early to mid-20th centuries have also been described as "red brick". According to historian William Whyte of the University of Oxford, Truscott's original definition includes
14720-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of
14848-768: Was also the first British Nobel laureate in 1902. The university is also associated with Professors Ronald Finn and Sir Cyril Clarke who jointly won the Lasker-DeBakey Clinical Medical Research Award in 1980 and Sir David Weatherall who won the Lasker-Koshland Special Achievement Award in Medical Science in 2010. These Lasker Awards are popularly known as America's Nobels . Over the 2013/2014 academic year, members of staff took part in numerous strikes after staff were offered
14976-496: Was established in 1881 as College Liverpool, admitting its first students in 1882. In 1884, it became part of the federal Victoria University . In 1894 Oliver Lodge , a professor at the university, made the world's first public radio transmission and two years later took the first surgical X-ray in the United Kingdom. The Liverpool University Press was founded in 1899, making it the third-oldest university press in England. Students in this period were awarded external degrees by
15104-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation
15232-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from
15360-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox
15488-542: Was one of several diseases introduced by the Columbian exchange to the New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in
15616-512: Was originally one of the nine civic universities founded in the major industrial cities of England in the 19th century. However, with the 1960s proliferation of plate glass universities and the reclassification of polytechnics in the Further and Higher Education Act 1992 as post-1992 universities , all British universities founded in the late 19th and early 20th centuries in major cities are now sometimes referred to as "red brick". Six of
15744-409: Was renamed after leading communist and anti-racist leader Dorothy Kuya . The University of Liverpool has a proud sporting tradition and has many premier teams in a variety of sports. The current sporting project comes under the title of Sport Liverpool and offers over 50 different sports ranging from football, rugby, cricket and hockey to others such as windsurfing, lacrosse and cheerleading. Many of
15872-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout
16000-650: Was the first among UK universities to develop their desktop computer power management solution, which has been widely adopted by other institutions. The university has subsequently piloted other advanced software approaches further increasing savings. The university has also been at the forefront of using the Condor HTC computing platform in a power saving environment. This software, which makes use of unused computer time for computationally intensive tasks usually results in computers being left turned on. The university has demonstrated an effective solution for this problem using
16128-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it
16256-516: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed
16384-401: Was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of the smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is
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