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80-457: Prior to MCF-7, it was not possible for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months. The patient, Frances Mallon died in 1970 due to metastatic breast cancer. Her cells were the source of much of current knowledge about breast cancer. At the time of sampling, she was a nun in the convent of Immaculate Heart of Mary in Monroe, Michigan under

160-560: A Swedish Empire colony. Established as a haven for religious and political tolerance, the colonial-era Province of Pennsylvania was known for its relatively peaceful relations with native tribes, innovative government system , and religious pluralism . Pennsylvania played a vital and historic role in the American Revolution and the ultimately successful quest for independence from the British Empire , hosting

240-620: A biracial member of the Oblate Sisters of Providence in Baltimore, established the institute in Monroe. Father Gillet found that Monroe had no school for the daughters of French Canadians and their descendants, most of whom were Catholic. He petitioned the local bishop , Peter Paul Lefevere , coadjutor bishop of Detroit , for a religious institute to assume teaching duties. The bishop declined, so Gillet invited three women to form

320-1045: A Farmer in Pennsylvania, To the Inhabitants of the British Colonies , which were published in the Pennsylvania Chronicle between December 2, 1767, and February 15, 1768. When the Founding Fathers convened in Philadelphia in 1774, 12 colonies sent representatives to the First Continental Congress . The Second Continental Congress , which began in May 1775, authored and signed the Declaration of Independence in Philadelphia, but when Philadelphia fell to

400-766: A century, the Pennsylvania General Assembly met at various places in the Philadelphia area before it began meeting regularly in Independence Hall in Philadelphia for 63 years. However, events such as the Paxton Boys massacres of 1763 had made the legislature aware of the need for a central capital. In 1799, the General Assembly moved to the Lancaster Courthouse. The Pennsylvania General Assembly met in

480-451: A heavy snowstorm, presumably because of a faulty flue . The General Assembly met at a nearby Methodist Church until a new capitol could be built. Following an architectural selection contest, Chicago architect Henry Ives Cobb was asked to design and build a replacement building. However, the legislature had little money to allocate to the project. When they dubbed the roughly finished, somewhat industrial Cobb Capitol building complete,

560-457: A leader in technology and healthcare. Similarly, Philadelphia has a concentration of university expertise. Healthcare, retail, transportation, and tourism are some of the state's growing industries of the postindustrial era. As in the rest of the nation, most residential population growth has occurred in suburban rather than central city areas, although both major cities have had significant revitalization in their downtown areas. Philadelphia anchors

640-450: A more general acknowledgement of Duchemin within the IHM community. Defunct Defunct In 2012, the Monroe campus was used for filming numerous scenes of Arnaud Desplechin 's movie Jimmy P: Psychotherapy of a Plains Indian (2013), which was entered in the 2013 Cannes Film Festival , depicting the now vanished Winter Veteran Hospital of Topeka, Kansas . Pennsylvania This

720-536: A new religious congregation. It would become known as the Sisters, Servants of the Immaculate Heart of Mary. The co-foundress and first religious superior of the Monroe community was Mother Theresa Maxis Duchemin, one of the first members of Oblate Sisters of Providence of Baltimore. It was the first religious congregation established in the country for women of African descent. On January 15, 1846,

800-469: A variety of settings; and working to improve the environment. The IHM is divided among three separate congregations . The Motherhouse currently houses more than 200 sisters, more than 100 of whom are aging and require supportive care. The beginnings of the institute came about in 1845 shortly after Father Louis Florent Gillet, C.Ss.R. , arrived in Monroe, Michigan, to become the pastor of St. Mary Parish. On November 10, Gillet and Theresa Maxis Duchemin,

880-706: Is an accepted version of this page Pennsylvania ( / ˌ p ɛ n s ɪ l ˈ v eɪ n i ə / PEN -sil- VAY -nee-ə , lit.   ' Penn's forest country ' ), officially the Commonwealth of Pennsylvania ( Pennsylvania Dutch : Pennsilfaani ), is a U.S. state spanning the Mid-Atlantic , Northeastern , Appalachian , and Great Lakes regions of the United States . It borders Delaware to its southeast, Maryland to its south, West Virginia to its southwest, Ohio and

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960-496: Is centered in and around Pittsburgh , the state's second-largest city. The state's subsequent five most populous cities are Allentown , Reading , Erie , Scranton , and Bethlehem . Pennsylvania's history of human habitation extends thousands of years before the foundation of the colonial Province of Pennsylvania in 1681. Archaeologists believe the first settlement of the Americas occurred at least 15,000 years ago, during

1040-849: Is in Duncannon in Perry County . According to the U.S. Department of Housing and Urban Development 's 2022 Annual Homeless Assessment Report , there were an estimated 12,691 homeless people in Pennsylvania. Among Pennsylvania residents, as of 2020, nearly three out of four, 74.5%, are native to the state and were born in Pennsylvania, 18.4% were born in a different U.S. state, 1.5% were born in Puerto Rico , U.S. Island areas, or born abroad to American parent(s), and 5.6% were foreign born. Foreign-born Pennsylvanians are largely from Asia (36.0%), Europe (35.9%), and Latin America (30.6%) with

1120-464: Is the fifth-most populated state in the U.S. after California , Texas , Florida , and New York . In 2019, net migration to other states resulted in a decrease of 27,718, and immigration from other countries resulted in an increase of 127,007. Net migration to Pennsylvania was 98,289. Migration of native Pennsylvanians resulted in a decrease of 100,000 people. 7.2% of the population was foreign-born as of 2021. Pennsylvania's center of population

1200-865: The British in the Philadelphia campaign , the Continental Congress moved west, where it met at the Lancaster courthouse on Saturday, September 27, 1777, and then to York . In York, the Second Continental Congress adopted the Articles of Confederation , largely authored by Pennsylvania delegate John Dickinson, that formed 13 independent States into a new union. Later, the Constitution was written, and Philadelphia

1280-524: The Clovis culture . By 1000 CE, in contrast to their nomadic hunter-gatherer ancestors , the native population of Pennsylvania had developed agricultural techniques and a mixed food economy. By the time European colonization of the Americas began, at least two major Native American tribes inhabited Pennsylvania. The first, the Lenape , spoke an Algonquian language and inhabited the eastern region of

1360-538: The Cold War . Pennsylvania's geography is highly diverse. The Appalachian Mountains run through the center of the state; the Allegheny and Pocono mountains span much of Northeastern Pennsylvania ; close to 60% of the state is forested . While it has no ocean shoreline, it has 140 miles (225 km) of waterfront along Lake Erie and the tidal Delaware River. Pennsylvania is the fifth-most populous state in

1440-545: The Delaware River to the east, 80°31' W to the west, and the 42° N to the north, except for a short segment on the western end where a triangle extends north to Lake Erie . The state has five geographical regions: Allegheny Plateau , Ridge and Valley , Atlantic Coastal Plain , Piedmont , and Erie Plain . Pennsylvania's diverse topography produces a variety of climates, though the entire state experiences cold winters and humid summers. Straddling two major zones,

1520-596: The First and Second Continental Congress in Philadelphia , which formed the Continental Army and appointed George Washington as its commander in 1775, and unanimously adopted the Declaration of Independence the following year. On December 12, 1787, Pennsylvania was the second state to ratify the U.S. Constitution . In July 1863, the Battle of Gettysburg , fought over three days in and around Gettysburg ,

1600-666: The Last Glacial Period , though it is unclear when humans first inhabited present-day Pennsylvania. Between 10,000 and 16,000 years ago, Native Americans crossed the two continents, arriving in North America . Meadowcroft Rockshelter in Jefferson Township includes the earliest known signs of human activity in Pennsylvania and perhaps all of North America, including the remains of a civilization that existed over 10,000 years ago and possibly pre-dated

1680-493: The New Sweden Colony in the region of Fort Christina on the site of present-day Wilmington, Delaware . New Sweden claimed and, for the most part, controlled the lower Delaware River region, including parts of present-day Delaware, New Jersey, and Pennsylvania, but settled few colonists there. On March 12, 1664, King Charles II of England gave James, Duke of York a grant that incorporated all lands included in

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1760-896: The Northeast megalopolis and is associated with the Northeastern United States . Pittsburgh is part of the Great Lakes megalopolis and is often associated with the Rust Belt . During the September 11, 2001, terrorist attacks on the United States , the small town of Shanksville, Pennsylvania , received worldwide attention after United Airlines Flight 93 crashed into a field in Stonycreek Township , located 1.75 miles (2.82 km) north of

1840-524: The Ohio River to its west, Lake Erie and New York to its north, the Delaware River and New Jersey to its east, and the Canadian province of Ontario to its northwest via Lake Erie . Pennsylvania was founded in 1681 through a royal land grant to William Penn , the son of the state's namesake . Prior to that, between 1638 and 1655, a southeast portion of the state was part of New Sweden ,

1920-517: The Secretary of War under President Abraham Lincoln . Control of the machine was subsequently passed on to Cameron's son J. Donald Cameron , whose ineffectiveness resulted in a transfer of power to the more shrewd Matthew Quay and finally to Boies Penrose . The post-Civil War era, known as the Gilded Age , saw the continued rise of industry in Pennsylvania. Pennsylvania was home to some of

2000-791: The Spanish–American War . Pennsylvania was an important industrial center in World War I , and the state provided over 300,000 soldiers for the military. On May 31, 1918, the Pittsburgh Agreement was signed in Pittsburgh to declare the formation of the independent state of Czechoslovakia with future Czechoslovak president Tomáš Masaryk . In 1922, 310,000 Pennsylvania miners joined the UMW General coal strike , which lasted 163 days and shut down most coal mines within

2080-672: The United States . Pennsylvania has 51 miles (82 km) of coastline along Lake Erie and 57 miles (92 km) of shoreline along the Delaware Estuary . Of the original Thirteen Colonies , Pennsylvania is the only state that does not border the Atlantic Ocean . The boundaries of the state are the Mason–Dixon line (39°43' N) to the south, Twelve-Mile Circle on the Pennsylvania- Delaware border,

2160-609: The University of Pennsylvania in Philadelphia . The university, one of nine colonial colleges , was the first college established in Pennsylvania and one of the first in the nation. Today, it is an Ivy League university, which is routinely ranked among the world's best universities. Dickinson College in Carlisle , founded by Benjamin Rush and named after John Dickinson, was the first college founded after Revolutionary War and

2240-624: The county commission and freedom of religion , which were subsequently replicated in many of the Thirteen Colonies . What had been Upland on the Pennsylvania side of the Pennsylvania-Delaware border was renamed Chester County when Pennsylvania instituted its colonial governments on March 4, 1681. Penn signed a peace treaty with Tamanend , leader of the Lenape, which began a long period of friendly relations between

2320-509: The seventh-largest metropolitan area in the country and one of the largest metropolitan areas in the world, and Pittsburgh is the center of the nation's 27th-largest metropolitan areas. As of 2020, the Lehigh Valley in eastern Pennsylvania is the nation's 69th-largest metropolitan area. Pennsylvania also has six additional metropolitan areas that rank among the nation's 200-most populous metropolitan areas. Philadelphia forms part of

2400-691: The 15th U.S. president and was the first president to be born in Pennsylvania. The Battle of Gettysburg , the major turning point of the American Civil War , took place near Gettysburg in July 1863. An estimated 350,000 Pennsylvanians served in the Union Army forces, including 8,600 African American military volunteers . The politics of Pennsylvania were for decades dominated by the financially conservative Republican -aligned Cameron machine , established by U.S. Senator Simon Cameron , later

2480-491: The 1980s, novices didn't even learn about Duchemin in formation... At one point, they even enlisted a cardinal to intervene in the publication of a book that might have outed them as having been co-founded by a black woman." In 1992, an IHM sister, Marger Gannon, published letters acknowledging Duchemin and her significance; this began a period of collaboration between the IHM and Oblate sisters (the latter of whom had always acknowledged Duchemin as their own co-founder), as well as

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2560-553: The 45th President of the United States Donald Trump occurred. Pennsylvania is 170 miles (274 km) north to south and 283 miles (455 km) east to west. Of a total 46,055 square miles (119,282 km ), 44,817 square miles (116,075 km ) are land, 490 square miles (1,269 km ) are inland waters, and 749 square miles (1,940 km ) are waters in Lake Erie . It is the 33rd-largest state in

2640-428: The 48 states. The Philadelphia Naval Shipyard served as an important naval base, and Pennsylvania produced important military leaders, including George C. Marshall , Hap Arnold , Jacob Devers , and Carl Spaatz . During the war, over a million Pennsylvanians served in the armed forces, and more Medals of Honor were awarded to Pennsylvanians than to individuals from any other state. The Three Mile Island accident

2720-788: The Detroit area, and Immaculate Heart of Mary High School in Westchester, Illinois . In 1948, the Michigan congregation began its first missionary work outside the continental United States when the Sisters opened a mission in Cayey, Puerto Rico . In 2008, the Sisters opened Detroit Cristo Rey High School ; they co-sponsor it with the Congregation of St. Basil . Struggling with enrollment and financial issues, Marygrove College ceased operations in 2019. Their co-founder, Mother Duchemin,

2800-480: The General Assembly refused to occupy the building. In 1901, political and popular indignation prompted a second contest that was restricted to Pennsylvania architects; Joseph Miller Huston of Philadelphia was chosen to design the present Pennsylvania State Capitol that incorporated Cobb's building into a magnificent public work, finished and dedicated in 1907. James Buchanan , a Franklin County native, served as

2880-1015: The Hurons abandoned much of their western territory and moved closer to the Susquehanna River, and the Iroquois and Mohawk tribes moved further north. Northwest of the Allegheny River was the Iroquoian Petun , who were fragmented into three groups during the Beaver Wars: the Petun of New York, the Wyandot of Ohio, and the Tiontatecaga of the Kanawha River in southern West Virginia. South of the Allegheny River

2960-481: The Immaculate Heart of Mary The Sisters, Servants of the Immaculate Heart of Mary ( I.H.M. ) is a Catholic religious institute of sisters, founded in 1845 by Fr. Louis Florent Gillet, CSsR , and Mother Theresa Maxis Duchemin , a co-founder of the Oblate Sister of Providence . Via their first Superior, Mother Duchemin, they were the first predominantly White order founded by a Black Catholic (though

3040-648: The Netherlands confirmed the English conquest on July 21, 1667, although there were temporary reversions. On September 12, 1672, during the Third Anglo-Dutch War , the Dutch reconquered New York Colony / New Amsterdam , establishing three County Courts, which went on to become original Counties in present-day Delaware and Pennsylvania. The one that later transferred to Pennsylvania was Upland. This

3120-563: The Quakers and the Indians. Additional treaties between Quakers and other tribes followed. The Treaty of Shackamaxon of William Penn was never violated. Between 1730 and when the Pennsylvania Colony was shut down by Parliament with the Currency Act in 1764, the Pennsylvania Colony made its own paper money to account for the shortage of actual gold and silver. The paper money was called Colonial Scrip . The Colony issued bills of credit, which were as good as gold or silver coins because of their legal tender status. Since they were issued by

3200-444: The United States , with over 13 million residents as of the 2020 United States census . The state is the 33rd-largest by area and has the ninth-highest population density among all states. The largest metropolitan statistical area is the southeastern Delaware Valley , which includes and surrounds Philadelphia, the state's largest and nation's sixth-most populous city. The second-largest metropolitan area, Greater Pittsburgh ,

3280-541: The ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes. Tumor necrosis factor alpha ( TNF alpha ) inhibits the growth of MCF-7 breast cancer cells. Treatment with anti-estrogens can modulate the secretion of insulin-like growth factor binding proteins . Omega-3 and 6 fatty acids such as EPA, DHA and AA has been reported to inhibit MCF-7 cell line growth and proliferation. PIK3CA helical mutations were identified in MCF-7, but with low AKT activation. Sisters, Servants of

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3360-429: The city's population as of 2000. In the 20th century, as Pennsylvania's historical national and even global leadership in mining largely ceased and its steelmaking and other heavy manufacturing sectors slowed, the state sought to grow its service and other industries to replace the jobs and economic productivity lost from the downturn of these industries. Pittsburgh's concentration of universities has enabled it to be

3440-420: The development of labor unions helped them gain living wages. However, the rise of unions also led to a rise of union busting with several private police forces springing up. Pennsylvania was the location of the first documented organized strike in North America, and Pennsylvania was the location of two hugely prominent strikes, the Great Railroad Strike of 1877 and the Coal Strike of 1902 . The eight-hour day

3520-417: The fifth and currently the sixth-largest city after decades of being among the top three. After 1990, as information-based industries became more important in the economy, state and local governments put more resources into the old, well-established public library system. Some localities, however, used new state funding to cut local taxes. New ethnic groups, especially Hispanics and Latinos , began entering

3600-415: The first St. Mary Academy in Monroe opened with 40 students.In 1858, the sisters established a mission to serve the German-speaking Catholic children of Pennsylvania , at the request of the Bishop of Philadelphia , the now- sainted John Neumann . As a result of this mission, a dispute broke out between the bishops of Detroit and Philadelphia regarding their jurisdiction over the Sisters. Mother Theresa

3680-463: The first. At the time, Pennsylvania was the most ethnically and religiously diverse of the thirteen colonies. Because a third of Pennsylvania's population spoke German , the Constitution was presented in German so those citizens could participate in the discussion about it. Reverend Frederick Muhlenberg , a Lutheran minister and the first Speaker of the U.S. House of Representatives , acted as chairman of Pennsylvania's ratifying convention. For half

3760-515: The government and not a banking institution, they were interest-free, largely defraying the expense of the government and therefore taxation of the people. It also promoted general employment and prosperity, since the government used discretion and did not issue excessive amounts that inflated the currency. Benjamin Franklin had a hand in creating this currency, whose utility, he said, was never to be disputed. The currency also met with "cautious approval" by Adam Smith . In 1740, Franklin also founded

3840-433: The land be called New Wales, but there were objections to that name, so he recommended Sylvania (from the Latin silva : "forest, woods"). The King named it Pennsylvania (literally "Penn's Woods") in honor of Admiral Penn. The younger Penn was embarrassed at this name, fearing that people would think he had named it after himself, but King Charles would not rename the grant. Penn established a government with two innovations,

3920-567: The largest chocolate manufacturer in North America. Heinz Company was also founded during this period. These huge companies exercised a large influence on the politics of Pennsylvania; as Henry Demarest Lloyd put it, oil baron John D. Rockefeller "had done everything with the Pennsylvania legislature except refine it". Pennsylvania created a Department of Highways and engaged in a vast program of road-building, while railroads continued to see heavy usage. The growth of industry eventually provided middle class incomes to working-class households after

4000-399: The largest steel companies in the world. Andrew Carnegie founded the Carnegie Steel Company in Pittsburgh and Charles M. Schwab founded Bethlehem Steel in Bethlehem . Other titans of industry, including John D. Rockefeller and Jay Gould , also operated in Pennsylvania. In the latter half of the 19th century, the U.S. oil industry was born in Western Pennsylvania , which supplied

4080-417: The majority of the state, except for the southeastern corner, has a humid continental climate ( Köppen climate classification Dfb ). The southern portion of the state has a humid subtropical climate. The largest city, Philadelphia , has a humid subtropical climate (Köppen Cfa ). Summers are generally hot and humid. Moving toward the mountainous interior of the state, the winter climate becomes colder,

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4160-416: The name of Sister Catherine Frances. MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231 , account for more than two-thirds of all abstracts reporting studies on mentioned breast cancer cell lines, as concluded from a Medline -based survey. MCF-7 cells have the following characteristics: This cell line retained several characteristics of differentiated mammary epithelium, including

4240-441: The north to West Virginia in the southwest, including the Susquehanna, Allegheny , and Monongahela rivers near present-day Pittsburgh . European disease and constant warfare with several neighboring tribes and groups of Europeans weakened these two tribes, and they were grossly outpaced financially as the Hurons and Iroquois blocked them from proceeding west into Ohio during the Beaver Wars . As they lost numbers and land,

4320-442: The north-central region with York , Carlisle , and the state capital Harrisburg on the Susquehanna River in the east-central region of the state. Altoona and Johnstown are in the state's west-central region. The state's three-most populated cities, in order of size, are Philadelphia, Pittsburgh, and Allentown. As of the 2020 U.S. census , Pennsylvania had a population of 13,011,844, up from 12,702,379 in 2010. Pennsylvania

4400-627: The number of cloudy days increases, and snowfall amounts are greater. Western areas of the state, particularly locations near Lake Erie , can receive over 100 inches (250 cm) of snowfall annually, and the entire state receives plentiful precipitation throughout the year. The state may be subject to severe weather from spring through summer into autumn. Tornadoes occur annually in the state, sometimes in large numbers, such as 30 recorded tornadoes in 2011; generally speaking, these tornadoes do not cause significant damage. Cities in Pennsylvania include Philadelphia , Reading , Lebanon , and Lancaster in

4480-473: The old Dauphin County Court House until December 1821 when the Federal -style Hills Capitol, named for Lancaster architect Stephen Hills , was constructed on a hilltop land grant of four acres set aside for a seat of state government in Harrisburg by the son and namesake of John Harris, Sr. , a Yorkshire native who founded a trading post and ferry on the east shore of the Susquehanna River in 1705. The Hills Capitol burned down on February 2, 1897, during

4560-491: The order hid this fact for 160 years). Founded (and still headquartered) in Monroe, Michigan , the sisters originally began as teachers. They have since added ministries of: pastoral care in hospitals, long-term care facilities and other health care settings; parish ministry and outreach to poor communities and individuals in need; social services; working with those with AIDS; providing spiritual direction and retreats; advocacy efforts; programs and services for older adults in

4640-408: The original Virginia Company of Plymouth Grant and other lands. This grant was in conflict with the Dutch claim for New Netherland , which included parts of today's Pennsylvania. On June 24, 1664, the Duke of York sold the portion of his large grant that included present-day New Jersey to John Berkeley and George Carteret for a proprietary colony. The land was not yet in British possession, but

4720-628: The other in Chester County, Pennsylvania . In 1920, St. Mary Academy and College had outgrown its facilities in Monroe. The institute made plans to construct a new college facility. The Sisters initially planned to build the new campus in Monroe, but Bishop Michael Gallagher invited them to build in nearby Detroit . There the college would have a larger field of influence and could offer a Catholic higher education to thousands of young women who might otherwise not have such an opportunity. The Sisters built their new college in Detroit and named it Marygrove College . On June 3, 1929, St. Mary Academy in Monroe

4800-429: The remainder from Africa (5%), North America (3.1%), and Oceania (0.4%). The state's largest ancestry groups, expressed as a percentage of total people who responded with a particular ancestry for the 2010 census, were German 28.5%, Irish 18.2%, Italian 12.8%, African Americans 9.6%, English 8.5%, Polish 7.2%, and French 4.2%. As of 2018, the top countries of origin for Pennsylvania's immigrants were India ,

4880-437: The sale boxed in the portion of New Netherland on the West side of the Delaware River. The British conquest of New Netherland began on August 29, 1664, when New Amsterdam was coerced to surrender while facing cannons on British ships in New York Harbor . The conquest was completed in October 1664, when the British captured Fort Casimir in what today is New Castle, Delaware . The Treaty of Breda between England, France, and

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4960-404: The southeast, Pittsburgh in the southwest, and the tri-cities of Allentown , Bethlehem , and Easton in the central east, known as the Lehigh Valley . The northeast includes the former anthracite coal mining cities of Scranton , Wilkes-Barre , Pittston , Nanticoke , and Hazleton . Erie is located in the northwest. State College is located in the central region. Williamsport is in

5040-464: The state to fill low-skill jobs in agriculture and service industries. For example, in Chester County , Mexican immigrants brought the Spanish language , increased Catholicism , high birth rates, and cuisine when they were hired as agricultural laborers; in some rural localities, they made up half or more of the population. Stateside Puerto Ricans built a large community in the state's third-largest city, Allentown , where they comprise over 40% of

5120-449: The state, then known as Lenapehoking . It included most of present-day New Jersey and the Lehigh Valley and Delaware Valley regions in eastern and southeastern Pennsylvania. The Lenape's territory ended somewhere between the Delaware River in the east and the Susquehanna River in central Pennsylvania. The second tribe, the Susquehannock , spoke an Iroquoian language and were based in Western Pennsylvania from New York state in

5200-525: The state. In 1923, President Calvin Coolidge established the Allegheny National Forest under the authority of the Weeks Act of 1911. The forest is located in the northwest part of the state in Elk , Forest , McKean , and Warren Counties for the purposes of timber production and watershed protection in the Allegheny River basin. The Allegheny is the state's only national forest. Pennsylvania manufactured 6.6 percent of total U.S. military armaments produced during World War II , ranking sixth among

5280-404: The state." The ensuing hostilities became known as Pontiac's War . After the Stamp Act Congress of 1765, delegate John Dickinson of Philadelphia wrote the Declaration of Rights and Grievances . The Congress was the first meeting of the Thirteen Colonies , which convened at the request of the Massachusetts assembly; nine of the 13 colonies sent delegates. Dickinson then wrote Letters from

5360-409: The town. All 40 civilians and 4 Al-Qaeda hijackers on board were killed. The hijackers had intended to crash the plane into either the United States Capitol or The White House . After learning from family members via air phone of the earlier attacks on the World Trade Center , however, Flight 93's passengers revolted against the hijackers and fought for control of the plane, causing it to crash. It

5440-426: The unification of the states. Established in 1773, it was ratified on September 9, 1783, five days after the Treaty of Paris . James Smith wrote that in 1763, "the Indians again commenced hostilities, and were busily engaged in killing and scalping the frontier inhabitants in various parts of Pennsylvania. This state was then a Quaker government, and at the first of this war the frontiers received no assistance from

5520-462: The vast majority of kerosene for years thereafter. As the Pennsylvania oil rush developed, Pennsylvania's oil boom towns, such as Titusville , rose and later fell. Coal mining, primarily in the state's Coal Region in the northeast region of the state, also was a major industry for much of the 19th and 20th centuries. In 1903, Milton S. Hershey began construction on a chocolate factory in Hershey, Pennsylvania ; The Hershey Company grew to become

5600-463: Was a nation known as Calicua, which may have been part of the Monongahela culture . In the 17th century, the Dutch and the English each claimed both sides of the Delaware River as part of their colonial lands in America. The Dutch were the first to take possession. By June 3, 1631, the Dutch began settling the Delmarva Peninsula by establishing the Zwaanendael Colony on the site of present-day Lewes, Delaware . In 1638, Sweden established

5680-503: Was destroyed by fire. This caused extreme difficulties for the IHM institute, as they were burdened with heavy debts from the building of Marygrove College. The cost of rebuilding the motherhouse and academy in Monroe was prohibitive. With the onset soon afterward of the Great Depression of 1929, their financial woes increased. Nevertheless, the institute finished the reconstruction and moved into their new facilities in 1932. The congregation established Marian and Immaculata high schools in

5760-550: Was eventually adopted, and the coal and iron police were banned. At the beginning of the 20th century, Pennsylvania's economy centered on steel production, logging , coal mining , textile production, and other forms of industrial manufacturing . A surge in immigration to the U.S. during the late 19th and early 20th centuries provided a steady flow of cheap labor for these industries, which often employed children and people who could not speak English from Southern and Eastern Europe . Thousands of Pennsylvanians volunteered during

5840-546: Was faulted by Bishop Lefevre for this and was removed from her office of Superior General . She was sent to the mission in Pennsylvania. Shortly after this, in 1859, the Sisters in that state separated from the community in Michigan and were established as an independent congregation under the Bishop of Philadelphia. This congregation later further split into two more, one based in Scranton, Pennsylvania (founded in 1871 ), and

5920-543: Was once again chosen to be cradle to the new nation. The Constitution was drafted and signed at the Pennsylvania State House in Philadelphia, now known as Independence Hall , the same building where the Declaration of Independence was previously adopted and signed in 1776. On December 12, 1787, Pennsylvania was the second state to ratify the U.S. Constitution , five days after Delaware became

6000-608: Was partially reversed on February 9, 1674, when the Treaty of Westminster ended the Third Anglo-Dutch War and reverted all political situations to the status quo ante bellum . The British retained the Dutch Counties with their Dutch names. By June 11, 1674, New York reasserted control over the outlying colonies, including Upland, and the names started to be changed to British names by November 11, 1674. Upland

6080-439: Was partitioned on November 12, 1674, producing the general outline of the current border between Pennsylvania and Delaware. On February 28, 1681, Charles II granted a land charter to Quaker leader William Penn to repay a debt of £16,000 (around £2,100,000 in 2008, adjusting for retail inflation) owed to William's father. The transaction represents one of the largest land grants to an individual in history. Penn proposed that

6160-613: Was the bloodiest and most decisive battle of the American Civil War , claiming over 50,000 Union and Confederate fatalities and repelling Robert E. Lee 's invasion of the North, leading to the Union's preservation . Throughout the late 19th and 20th centuries, the state's manufacturing-based economy contributed to the development of much of the nation's early infrastructure, including key bridges, skyscrapers , and military hardware used in U.S.-led victories in World War I , World War II , and

6240-493: Was the first African American to found a predominantly White order. She was one of the earliest Black Mother Superiors in the nation. She was also the first US-born Black Catholic to become a religious sister. The IHM sisters, however, scrubbed their records of Duchemin for 160 years. "[They] did not want to be associated with a black sister. It was "embarrassing" and "unpleasant," as sisters wrote in various letters. It would scare white people away from their ministries... before

6320-441: Was the most significant nuclear accident in U.S. commercial nuclear power plant history. The state was hard-hit by the decline and restructuring of the steel industry and other heavy industries during the late 20th century. With job losses came heavy population losses, especially in the state's largest cities. Pittsburgh lost its place among the top ten most populous cities in the United States by 1950, and Philadelphia dropped to

6400-657: Was the only one of the four aircraft hijacked that day that never reached its intended target and the heroism of the passengers has been commemorated. Since 2003, the Tekko anime convention has been held annually in Pittsburgh. In October 2018, the Tree of Life – Or L'Simcha Congregation , a conservative Jewish synagogue, experienced the Pittsburgh synagogue shooting , which resulted in 11 fatalities. On July 13, 2024, near Butler, Pennsylvania , an assassination attempt on

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