62-571: A hangover is the experience of various unpleasant physiological and psychological effects usually following the consumption of alcohol , such as wine , beer , and liquor . Hangovers can last for several hours or for more than 24 hours. Typical symptoms of a hangover may include headache , drowsiness , concentration problems, dry mouth , dizziness , fatigue , gastrointestinal distress (e.g., nausea , vomiting , diarrhea ), absence of hunger , light sensitivity , depression , sweating , hyper-excitability, irritability , and anxiety . While
124-433: A dehydrating effect by causing increased urine production (diuresis), which could cause thirst, dry mouth, dizziness and may lead to an electrolyte imbalance . Studies suggest that electrolyte changes play only a minor role in the genesis of the alcohol hangover and are caused by dehydration effects. Drinking water may help relieve symptoms as a result of dehydration but it is unlikely that rehydration significantly reduces
186-484: A Spanish slang term for a glass of beer. Similar is the Irish 'brown bottle flu' derived from the type of bottle common to beer. In German, the hangover is known as a "Kater", literally a tomcat . The most likely origin of the term is a pun on catarrh . Nowadays, "Kater" often is understood literally, resulting in cat motifs as depictions of hangovers. Alcohol hangover has considerable economic consequences. In Finland ,
248-653: A bell and visual stimuli. In the 19th century, physiological knowledge began to accumulate at a rapid rate, in particular with the 1838 appearance of the Cell theory of Matthias Schleiden and Theodor Schwann . It radically stated that organisms are made up of units called cells. Claude Bernard 's (1813–1878) further discoveries ultimately led to his concept of milieu interieur (internal environment), which would later be taken up and championed as " homeostasis " by American physiologist Walter B. Cannon in 1929. By homeostasis, Cannon meant "the maintenance of steady states in
310-683: A car or operating heavy machinery . An alcohol hangover is associated with a variety of symptoms that may include drowsiness, headache, concentration problems, dry mouth, dizziness, gastrointestinal complaints, fatigue, sweating, nausea , hyper-excitability, anxiety , and a feeling of general discomfort that may last more than 24 hours. Alcohol hangover symptoms develop when blood alcohol concentration falls considerably and peak when it returns to almost zero. Hangover symptoms validated in controlled studies include general malaise , thirst, headache , feeling dizzy or faint, tiredness, loss of appetite, nausea, stomach ache, and feeling as though one's heart
372-591: A car or operating heavy machinery are also negatively influenced. In mid-2017, it was reported that one company in the UK allows sick days when hung over. As of 2019, South Korea's 'hangover-cure product' market, which comes in various formulations such as beverages, pills, and jelly, is a 250 billion won (US$ 213 million) industry. Psychological research of alcohol hangover is growing rapidly. The Alcohol Hangover Research Group had its inaugural meeting in June 2010 as part of
434-432: A country with a population of 5 million persons, over 1 million workdays are lost each year because of hangovers. The average annual opportunity cost due to hangovers are estimated as 2000 (USD) per working adult. The socioeconomic implications of an alcohol hangover include workplace absenteeism, impaired job performance, reduced productivity and poor academic achievement. Potentially dangerous daily activities such as driving
496-503: A distinct subdiscipline. In 1920, August Krogh won the Nobel Prize for discovering how, in capillaries, blood flow is regulated. In 1954, Andrew Huxley and Hugh Huxley, alongside their research team, discovered the sliding filaments in skeletal muscle , known today as the sliding filament theory. Recently, there have been intense debates about the vitality of physiology as a discipline (Is it dead or alive?). If physiology
558-430: A higher buildup of acetaldehyde than normally seen in other groups. The high concentration of acetaldehyde causes the alcohol flush reaction , colloquially known as the "Asian Flush". Since the alcohol flush reaction is highly uncomfortable and the possibility of hangovers is immediate and severe, people with this gene variant are less likely to become alcoholics . Acetaldehyde may also influence glutathione peroxidase ,
620-412: A key antioxidant enzyme, and increases the susceptibility to oxidative stress . Likewise, acetic acid (or the acetate ion ) can cause additional problems. One study found that injecting sodium acetate into rats caused them to have nociceptive behavior (headaches). In addition, there is a biochemical explanation for this finding. High acetate levels cause adenosine to accumulate in many parts of
682-459: A medical field originates in classical Greece , at the time of Hippocrates (late 5th century BC). Outside of Western tradition, early forms of physiology or anatomy can be reconstructed as having been present at around the same time in China , India and elsewhere. Hippocrates incorporated the theory of humorism , which consisted of four basic substances: earth, water, air and fire. Each substance
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#1732791108868744-485: A medical point of view. Health care professionals prefer to study alcohol abuse from a standpoint of treatment and prevention, and there is a view that the hangover provides a useful, natural and intrinsic disincentive to excessive drinking. Within the limited amount of serious study on the subject, there is debate about whether a hangover may be prevented or at least mitigated. There is also a vast body of folk medicine and simple quackery . A four-page literature review in
806-412: A mitigating effect on hangover symptoms, while some whiskey congeners such as butanol protect the stomach against gastric mucosal damage in the rat. Different types of alcoholic beverages contain different amounts of congeners. In general, dark liquors have a higher concentration while clear liquors have a lower concentration. Whereas vodka has virtually no more congeners than pure ethanol, bourbon has
868-414: A total congener content 37 times higher than that found in vodka. Several studies have examined whether certain types of alcohol cause worse hangovers. All four studies concluded that darker liquors, which have higher congeners, produced worse hangovers. One even showed that hangovers were worse and more frequent with darker liquors. In a 2006 study, an average of 14 standard drinks (330 ml each) of beer
930-430: A unified science of life based on the cell actions, later renamed in the 20th century as cell biology . In the 20th century, biologists became interested in how organisms other than human beings function, eventually spawning the fields of comparative physiology and ecophysiology . Major figures in these fields include Knut Schmidt-Nielsen and George Bartholomew . Most recently, evolutionary physiology has become
992-399: Is methanol . It is naturally formed in small quantities during fermentation and it can be accidentally concentrated by improper distillation techniques. Metabolism of methanol produces some extremely toxic compounds, such as formaldehyde and formic acid , which may play a role in the severity of hangover. Ethanol slows the conversion of methanol into its toxic metabolites so that most of
1054-550: Is a subdiscipline of botany concerned with the functioning of plants. Closely related fields include plant morphology , plant ecology , phytochemistry , cell biology , genetics , biophysics , and molecular biology . Fundamental processes of plant physiology include photosynthesis , respiration , plant nutrition , tropisms , nastic movements , photoperiodism , photomorphogenesis , circadian rhythms , seed germination , dormancy , and stomata function and transpiration . Absorption of water by roots, production of food in
1116-427: Is achieved through communication that occurs in a variety of ways, both electrical and chemical. Changes in physiology can impact the mental functions of individuals. Examples of this would be the effects of certain medications or toxic levels of substances. Change in behavior as a result of these substances is often used to assess the health of individuals. Much of the foundation of knowledge in human physiology
1178-400: Is essential for diagnosing and treating health conditions and promoting overall wellbeing. It seeks to understand the mechanisms that work to keep the human body alive and functioning, through scientific enquiry into the nature of mechanical, physical, and biochemical functions of humans, their organs, and the cells of which they are composed. The principal level of focus of physiology is at
1240-469: Is known for having a corresponding humor: black bile, phlegm, blood, and yellow bile, respectively. Hippocrates also noted some emotional connections to the four humors, on which Galen would later expand. The critical thinking of Aristotle and his emphasis on the relationship between structure and function marked the beginning of physiology in Ancient Greece . Like Hippocrates , Aristotle took to
1302-498: Is no evidence that any treatments for hangovers are effective. Recommendations for foods, drinks and activities to relieve hangover symptoms abound. The ancient Romans , on the authority of Pliny the Elder , favored raw owl 's eggs or fried canary , while the " prairie oyster " restorative, introduced at the 1878 Paris World Exposition, calls for raw egg yolk mixed with Worcestershire sauce , Tabasco sauce , salt and pepper. By 1938,
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#17327911088681364-580: Is perhaps less visible nowadays than during the golden age of the 19th century, it is in large part because the field has given birth to some of the most active domains of today's biological sciences, such as neuroscience , endocrinology , and immunology . Furthermore, physiology is still often seen as an integrative discipline, which can put together into a coherent framework data coming from various different domains. Initially, women were largely excluded from official involvement in any physiological society. The American Physiological Society , for example,
1426-483: Is racing. Some symptoms such as changes in sleep pattern and gastrointestinal distress are attributed to direct effects of the alcohol intoxication, or withdrawal symptoms . Drowsiness and impaired cognitive function are the two dominant features of alcohol hangover. The processes which lead to hangovers are still poorly understood. Several pathophysiological changes may give rise to the alcohol hangover including increased levels of acetaldehyde, hormonal alterations of
1488-464: Is still secondary to the total amount of ethanol consumed. Although methanol is not produced in toxic amounts by fermentation of sugars from grain starches, it is a major occurrence in fruit spirits . However, in modern times, reducing methanol with the absorption of a molecular sieve is a practical method for production. This food ingredient article is a stub . You can help Misplaced Pages by expanding it . This article about an alcohol
1550-649: Is the scientific study of functions and mechanisms in a living system . As a subdiscipline of biology , physiology focuses on how organisms , organ systems , individual organs , cells , and biomolecules carry out chemical and physical functions in a living system. According to the classes of organisms , the field can be divided into medical physiology , animal physiology , plant physiology , cell physiology , and comparative physiology . Central to physiological functioning are biophysical and biochemical processes, homeostatic control mechanisms, and communication between cells. Physiological state
1612-555: Is the condition of normal function. In contrast, pathological state refers to abnormal conditions , including human diseases . The Nobel Prize in Physiology or Medicine is awarded by the Royal Swedish Academy of Sciences for exceptional scientific achievements in physiology related to the field of medicine . Because physiology focuses on the functions and mechanisms of living organisms at all levels, from
1674-631: The British Medical Journal concludes: "No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover. The most effective way to avoid the symptoms of alcohol induced hangover is to avoid drinking." Most remedies do not significantly reduce overall hangover severity. Some compounds reduce specific symptoms such as vomiting and headache, but are not effective in reducing other common hangover symptoms such as drowsiness and fatigue. Some sources indicate there
1736-725: The Research Society on Alcoholism (RSA) 33rd Annual Scientific Meeting in San Antonio , Texas , USA. In 2012, Éduc'alcool, a Quebec -based non-profit organization that aims to educate the public on the responsible use of alcohol, published a report noting hangovers have long-lasting effects that inhibit the drinker's capabilities a full 24 hours after heavy drinking. Physiological Physiology ( / ˌ f ɪ z i ˈ ɒ l ə dʒ i / ; from Ancient Greek φύσις ( phúsis ) 'nature, origin' and -λογία ( -logía ) 'study of')
1798-529: The Ritz-Carlton Hotel provided a hangover remedy in the form of a mixture of Coca-Cola and milk (Coca-Cola itself having been invented, by some accounts, as a hangover remedy). Alcoholic writer Ernest Hemingway relied on tomato juice and beer. Other purported hangover cures include cocktails such as Bloody Mary or Black Velvet (consisting of equal parts champagne and stout ). A 1957 survey by an American folklorist found widespread belief in
1860-463: The alcoholic beverages industry, congeners are substances produced during fermentation other than the desired type of alcohol ( ethanol ). These substances include small amounts of chemicals such as methanol and other alcohols (known as fusel alcohols ), acetone , acetaldehyde , esters , tannins , and aldehydes (e.g. furfural ). Congeners are responsible for most of the taste and aroma of distilled alcoholic beverages, and contribute to
1922-458: The cytokine pathways and decrease of the availability of glucose . Additional associated phenomena are dehydration , metabolic acidosis , disturbed prostaglandin synthesis, increased cardiac output , vasodilation , sleep deprivation and insufficient eating. Some complex organic molecules found in alcoholic beverages known as congeners may play an important role in producing hangover effects because some, such as methanol , are metabolized to
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1984-621: The NAD/NADH redox system, alcoholic beverages make normal bodily functions more difficult. Consequences of the alcohol induced redox changes in the human body include increased triglyceride production, increased amino acid catabolism , inhibition of the citric acid cycle , lactic acidosis , ketoacidosis , hyperuricemia , disturbance in cortisol and androgen metabolism and increased fibrogenesis . The metabolism of glucose and insulin are also influenced. However, recent studies showed no significant correlation between hangover severity and
2046-418: The blood . Santorio Santorio in 1610s was the first to use a device to measure the pulse rate (the pulsilogium ), and a thermoscope to measure temperature. In 1791 Luigi Galvani described the role of electricity in the nerves of dissected frogs. In 1811, César Julien Jean Legallois studied respiration in animal dissection and lesions and found the center of respiration in the medulla oblongata . In
2108-421: The body and the physiological processes through which they are regulated." In other words, the body's ability to regulate its internal environment. William Beaumont was the first American to utilize the practical application of physiology. Nineteenth-century physiologists such as Michael Foster , Max Verworn , and Alfred Binet , based on Haeckel 's ideas, elaborated what came to be called "general physiology",
2170-720: The brain. But when the rats were given caffeine, which blocks the action of adenosine, they no longer experienced headaches. In addition to ethanol and water, most alcoholic drinks also contain congeners , either as flavoring or as a by-product of fermentation and the wine aging process . While ethanol is by itself sufficient to produce most hangover effects, congeners may potentially aggravate hangover and other residual effects to some extent. Congeners include substances such as amines , amides , acetones , acetaldehydes, polyphenols , methanol, histamines , fusel oil , esters , furfural , and tannins , many but not all of which are toxic. One study in mice indicates that fusel oil may have
2232-512: The causes of a hangover are still poorly understood, several factors are known to be involved including acetaldehyde accumulation, changes in the immune system and glucose metabolism, dehydration , metabolic acidosis , disturbed prostaglandin synthesis, increased cardiac output , vasodilation , sleep deprivation , and malnutrition . Beverage-specific effects of additives or by-products such as congeners in alcoholic beverages also play an important role. The symptoms usually occur after
2294-522: The concentrations of various hormones , electrolytes , free fatty acids , triglycerides , lactate, ketone bodies , cortisol, and glucose in blood and urine samples. Alcohol also induces the CYP2E1 enzyme, which metabolizes ethanol and other substances into more reactive toxins. In particular, in binge drinking the enzyme is activated and plays a role in creating a harmful condition known as oxidative stress which can lead to cell death. Acetaldehyde,
2356-542: The death rate from surgery by a substantial amount. The Physiological Society was founded in London in 1876 as a dining club. The American Physiological Society (APS) is a nonprofit organization that was founded in 1887. The Society is, "devoted to fostering education, scientific research, and dissemination of information in the physiological sciences." In 1891, Ivan Pavlov performed research on "conditional responses" that involved dogs' saliva production in response to
2418-454: The efficacy of heavy fried foods, tomato juice and sexual activity. Other untested or discredited treatments include: Hangovers occur commonly. A somewhat dated French idiomatic expression for hangover is "mal aux cheveux", literally "sore hair" (or "[even] my hair hurts"). Some terms for 'hangover' are derived from names for liquor, for example, in Chile a hangover is known as a caña from
2480-431: The election of women was celebrated in 2015 with the publication of the book "Women Physiologists: Centenary Celebrations And Beyond For The Physiological Society." ( ISBN 978-0-9933410-0-7 ) Prominent women physiologists include: Human physiology Animal physiology Plant physiology Fungal physiology Protistan physiology Algal physiology Bacterial physiology Congener (alcohol) In
2542-592: The first by-product of ethanol, is between 10 and 30 times more toxic than alcohol itself and can remain at an elevated plateau for many hours after initial ethanol consumption. In addition, certain genetic factors can amplify the negative effects of acetaldehyde. For example, some people (predominantly East Asians ) have a mutation in their alcohol dehydrogenase gene that makes this enzyme unusually fast at converting ethanol to acetaldehyde. In addition, about half of all East Asians convert acetaldehyde to acetic acid more slowly (via acetaldehyde dehydrogenase ), causing
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2604-502: The humoral theory of disease, which also consisted of four primary qualities in life: hot, cold, wet and dry. Galen ( c. 130 –200 AD) was the first to use experiments to probe the functions of the body. Unlike Hippocrates, Galen argued that humoral imbalances can be located in specific organs, including the entire body. His modification of this theory better equipped doctors to make more precise diagnoses. Galen also played off of Hippocrates' idea that emotions were also tied to
2666-458: The humors, and added the notion of temperaments: sanguine corresponds with blood; phlegmatic is tied to phlegm; yellow bile is connected to choleric; and black bile corresponds with melancholy. Galen also saw the human body consisting of three connected systems: the brain and nerves, which are responsible for thoughts and sensations; the heart and arteries, which give life; and the liver and veins, which can be attributed to nutrition and growth. Galen
2728-416: The immune system. The concentration of several cytokines have been found to be significantly increased in the blood after alcohol consumption. These include interleukin 12 (IL-12), interferon gamma (IFNγ) and interleukin 10 (IL-10). Some pharmacological studies such as on tolfenamic acid and Opuntia ficus-indica (OFI) have also indicated an involvement of the immune system. These studies suggest that
2790-410: The individual." In more differentiated organisms, the functional labor could be apportioned between different instruments or systems (called by him as appareils ). In 1858, Joseph Lister studied the cause of blood coagulation and inflammation that resulted after previous injuries and surgical wounds. He later discovered and implemented antiseptics in the operating room, and as a result, decreased
2852-639: The intoxicating effect of the alcohol begins to wear off, generally the morning after a night of heavy drinking. Though many possible remedies and folk cures have been suggested, there is no compelling evidence to suggest that any are effective for preventing or treating hangovers. Avoiding alcohol or drinking in moderation are the most effective ways to avoid a hangover. The socioeconomic consequences of hangovers include workplace absenteeism , impaired job performance , reduced productivity and poor academic achievement . A hangover may also impair performance during potentially dangerous daily activities such as driving
2914-402: The leaves, and growth of shoots towards light are examples of plant physiology. Human physiology is the study of how the human body's systems and functions work together to maintain a stable internal environment. It includes the study of the nervous, endocrine, cardiovascular, respiratory, digestive, and urinary systems, as well as cellular and exercise physiology. Understanding human physiology
2976-449: The level of organs and systems within systems. The endocrine and nervous systems play major roles in the reception and transmission of signals that integrate function in animals. Homeostasis is a major aspect with regard to such interactions within plants as well as animals. The biological basis of the study of physiology, integration refers to the overlap of many functions of the systems of the human body, as well as its accompanied form. It
3038-580: The methanol can be excreted harmlessly in the breath and urine without forming its toxic metabolites. This may explain the temporary postponement of symptoms reported in the common remedy of drinking more alcohol to relieve hangover symptoms. Since methanol metabolism is effectively inhibited by consumption of alcohol, methanol accumulates during drinking and only begins to be metabolized once ethanol has been cleared. This delayed action makes it an attractive candidate explanation for delayed post-intoxication symptoms and correlations between methanol concentrations and
3100-455: The molecular and cellular level to the level of whole organisms and populations, its foundations span a range of key disciplines: There are many ways to categorize the subdisciplines of physiology: Although there are differences between animal , plant , and microbial cells, the basic physiological functions of cells can be divided into the processes of cell division , cell signaling , cell growth , and cell metabolism . Plant physiology
3162-405: The notably toxic substances formaldehyde and formic acid . After being ingested, the ethanol in alcoholic beverages is first converted to acetaldehyde by the enzyme alcohol dehydrogenase and then to acetic acid by oxidation and egestion process. These reactions also convert nicotinamide adenine dinucleotide (NAD) to its reduced form NADH in a redox reaction . By causing an imbalance of
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#17327911088683224-409: The notion of physiological division of labor, which allowed to "compare and study living things as if they were machines created by the industry of man." Inspired in the work of Adam Smith , Milne-Edwards wrote that the "body of all living beings, whether animal or plant, resembles a factory ... where the organs, comparable to workers, work incessantly to produce the phenomena that constitute the life of
3286-497: The presence and severity of alcohol hangover. Alcohol's effect on the stomach lining can account for nausea because alcohol stimulates the production of hydrochloric acid in the stomach. Studies show that alcohol hangover is associated with a decrease in blood glucose concentration (less than 70 mg/dl), but the relationship between blood glucose concentration and hangover severity is unclear. Also known as insulin shock, hypoglycemia can lead to coma or even death. In current research,
3348-521: The presence and severity of hangover symptoms can probably be reduced by administration of a cyclooxygenase inhibitor such as aspirin or ibuprofen . Several factors which do not in themselves cause alcohol hangover are known to influence its severity. These factors include personality, genetics, health status, age, sex, associated activities during drinking such as smoking, the use of other drugs, physical activity such as dancing, as well as sleep quality and duration. Hangovers are poorly understood from
3410-448: The presence of hangover symptoms that have been found in studies. The metabolic processes required for alcohol elimination deplete essential vitamins and electrolytes. Furthermore, alcohol is a diuretic , causing excretion of electrolytes through urination. After a night of drinking, the resulting lack of key B and C vitamins, as well as potassium, magnesium, and zinc may cause fatigue, aching and other hangover-like symptoms. Ethanol has
3472-602: The same year, Charles Bell finished work on what would later become known as the Bell–Magendie law , which compared functional differences between dorsal and ventral roots of the spinal cord . In 1824, François Magendie described the sensory roots and produced the first evidence of the cerebellum's role in equilibration to complete the Bell–Magendie law. In the 1820s, the French physiologist Henri Milne-Edwards introduced
3534-402: The significant relationship between immune factors and hangover severity is the most convincing among all factors so far studied. An imbalance of the immune system , in particular of cytokine metabolism has been identified as playing a role in the pathophysiology of the hangover state. Especially the hangover symptoms nausea, headache, and fatigue have been suggested to be mediated by changes in
3596-405: The taste of non-distilled drinks. Brandy , rum and red wine have the highest amount of congeners, while vodka and beer have the least. Congeners are the basis of alcohol congener analysis , a sub-discipline of forensic toxicology which determines what a person drank. There is some evidence that high-congener drinks induce more severe hangovers , but the effect is not well studied and
3658-402: Was also the founder of experimental physiology. And for the next 1,400 years, Galenic physiology was a powerful and influential tool in medicine . Jean Fernel (1497–1558), a French physician, introduced the term "physiology". Galen, Ibn al-Nafis , Michael Servetus , Realdo Colombo , Amato Lusitano and William Harvey , are credited as making important discoveries in the circulation of
3720-955: Was founded in 1887 and included only men in its ranks. In 1902, the American Physiological Society elected Ida Hyde as the first female member of the society. Hyde, a representative of the American Association of University Women and a global advocate for gender equality in education, attempted to promote gender equality in every aspect of science and medicine. Soon thereafter, in 1913, J.S. Haldane proposed that women be allowed to formally join The Physiological Society , which had been founded in 1876. On 3 July 1915, six women were officially admitted: Florence Buchanan , Winifred Cullis , Ruth Skelton , Sarah C. M. Sowton , Constance Leetham Terry , and Enid M. Tribe . The centenary of
3782-404: Was needed to produce a hangover, but only 7 to 8 drinks was required for wine or liquor (note that one standard drink has the same amount of alcohol regardless of type). Another study ranked several drinks by their ability to cause a hangover as follows (from low to high): distilled ethanol diluted with fruit juice, beer, vodka, gin, white wine, whisky, rum, red wine and brandy. One potent congener
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#17327911088683844-410: Was provided by animal experimentation . Due to the frequent connection between form and function, physiology and anatomy are intrinsically linked and are studied in tandem as part of a medical curriculum. Involving evolutionary physiology and environmental physiology , comparative physiology considers the diversity of functional characteristics across organisms. The study of human physiology as
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