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MRC Mitochondrial Biology Unit

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30-851: The MRC Mitochondrial Biology Unit (formerly the MRC Dunn Human Nutrition Unit ) is a department of the School of Clinical Medicine at the University of Cambridge , funded through a strategic partnership between the Medical Research Council and the University. It is located at the Addenbrooke’s Hospital / Cambridge Biomedical Campus site in Cambridge, England . The unit is concerned with

60-574: A network that encourages local collaborations between universities, NHS hospitals, and other research organisations. The CIMR is a cross-departmental institute in the University of Cambridge , receiving funding from the Wellcome Trust . Research is focused on four main areas: misfolded proteins and disease, intracellular membrane traffic , autoimmune disease and haematopoietic stem cell biology. The Wolfson Brain Imaging Centre

90-676: Is a department of the School of Clinical Medicine of the University of Cambridge , funded by the Medical Research Council. It is focused on research to understand mitochondrial process and their involvement in human diseases. It is co-located with the Cambridge Institute for Medical Research in the Wellcome Trust/MRC Building. The Institute of Metabolic Science (IMS) is dedicated to research, education, prevention and clinical care in

120-687: Is a large teaching hospital , and the central focus of the campus. The Rosie Hospital is Cambridge's first purpose-built maternity hospital, opened in October 1983. A multimillion-pound extension of the Rosie Hospital was completed in 2012. The Royal Papworth Hospital moved to new premises on the Cambridge Biomedical Campus in Spring 2019. AstraZeneca's global research and development facility, The Discovery Centre,

150-507: Is designed for those who already hold bachelor's degrees. This course has an intensive 2–year component with a mix of pre-clinical and clinical teaching, students attend the same lectures and practicals as 1st and 2nd year A100 students during the 8 week terms. They complete the Year 4 placements in the holidays and sit both the A100 2nd year and 4th year exams in the second year of their course. Then

180-432: Is located on the campus and is home to over 2,000 employees working in medicines discovery and development, in both small molecules and biologics . Research activities span all preclinical functional groups, including antibody engineering, medicinal chemistry and high throughput screening. The University of Cambridge Medical School , established in 1976. The LMB is a molecular biology research institute funded by

210-533: Is primarily focused on stem cell biology and/or translation. The SCI is principally funded by the Wellcome Trust and the Medical Research Council . The Wellcome Trust also funds the SCI's internationally competitive 4-Year PhD Programme in Stem Cell Biology and Medicine. Stem cell biology and regenerative medicine research is a designated University of Cambridge Strategic Initiative. The aims of

240-621: Is the medical school of the University of Cambridge in England . The medical school is considered as being one of the most prestigious in the world, ranking as 1st in The Complete University Guide, followed by Oxford University Medical School , Harvard Medical School , and Stanford School of Medicine and 2nd in the world in the 2023 Times Higher Education Ranking. The Cambridge Graduate Course in Medicine (A101)

270-535: Is the most competitive course offered by the University and in the UK, and is among the most competitive medical programs for entry in the world. The school is located alongside Addenbrooke's Hospital and other institutions in multiple buildings across the Cambridge Biomedical Campus . The Clinical School offers the A100 six-year standard course (accepting approximately 280 students each year) or

300-539: The Medical Research Council (MRC). Its original research focus was to investigate the role of vitamins in human health. Under the directorship of Egon Kodicek this focus changed to more general nutritional research. The Unit was restructured in 1998 under the directorship of Professor Sir John Walker to focus on mitochondrial research. The Unit was renamed in 2009 to the Mitochondrial Biology Unit to reflect its mitochondrial expertise. In March 2017

330-763: The Medical Research Council and the National Health Service . It was created in 1993 to study disease in the population and to identify, evaluate and monitor public healthcare interventions. The Cambridge Academy for Science and Technology is a secondary school for 14- to 18-year-olds offering GCSE, B-Tech and A-Level courses. It opened on 8 September 2014 in the Deakin Centre as the University Technical College Cambridge. On Friday 19 September 2017, it moved into its own building on Robinson Way, situated next to

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360-697: The University of Cambridge Department of Oncology, the MRC Cancer Cell Unit , and the University of Cambridge "Cambridge Molecular Therapeutics Programme". It was built in 2001 with funding from the Medical Research Council and a donation to the University of Cambridge from Hutchison Whampoa Ltd . The Hutchison/MRC Research Centre is a member institute of the Cambridge Cancer Centre, a virtual organisation of Cambridge researchers whose work has current or potential application to cancer research . The MRC Mitochondrial Biology Unit

390-513: The Wellcome Trust , Cancer Research UK , the University of Cambridge 's medical school , and the United Kingdom's governmental Medical Research Council , which has National Institute for Health and Care Research -designated biomedical research centre status. Cambridge Biomedical Campus is an accredited UK academic health and science centre. The Cambridge Biomedical Campus is home to the following institutions. Addenbrooke's Hospital

420-473: The A101 accelerated graduate course (accepting approximately 40 students each year). Admission is extremely competitive, with the offered courses having among the lowest acceptance rates in the university. Around 10% of applicants were accepted to the A100 standard course for 2022 entry, with 22 places for overseas fee-status applicants. Around 3% of applicants were accepted to the A101 graduate course in 2023. On

450-694: The Institute focuses primarily on Tumour Ecology and Evolution, with investigations across four main areas: The centre was officially opened by Queen Elizabeth II in February 2007. In 2018, Professor Gregory Hannon was announced as the new Director, taking over from Professor Simon Tavaré . Senior Group Leader at the institute, Professor Richard Gilbertson , is the Director of the Cancer Research UK Cambridge Centre,

480-478: The Institute of Public Health, Cambridge Centre for Brain Repair is a subsidiary of the University of Cambridge Department of Clinical Neurosciences. It is a research institute aiming to "understand, and eventually to alleviate and repair damage to the brain and spinal cord which results from injury or neurodegenerative disease." The Institute for Public Health is a partnership between the University of Cambridge ,

510-621: The Long Road Sixth Form College, parallel to the Bio-Medical Campus which encompasses Addenbrooke's Hospital , rebranded as Cambridge Academy for Science and Technology. Other entities located on the Cambridge Biomedical Campus include: Within the next decade, there are scheduled to be 3 new hospitals (including one rebuild) on the Biomedical Campus, bringing the total number of hospitals on

540-424: The SCI are: The SCI was formed in 2012 following an £8m investment by the Wellcome Trust and the Medical Research Council . The SCI will eventually be housed in a purpose-built 8000m facility to be constructed on the Cambridge Biomedical Campus site. The Cancer Research UK Cambridge Institute is one of four core funded Cancer Research UK Institutes and a department of the University of Cambridge. In 2018,

570-736: The UK Medical Research Council . It was founded in Cambridge in 1947 as the Unit for Research on the Molecular Structure of Biological Systems and moved to a site adjacent to Addenbrooke's Hospital in 1962. A 27,000m replacement building close to the previous site was completed in 2012 and opened in May 2013. The laboratory has won twelve Nobel Prizes including the 1962 prize ( Physiology or Medicine ) awarded for

600-765: The Unit was transferred from the MRC to the University of Cambridge . The current director of the Unit is Professor Judy Hirst . The Unit has three major scientific aims: The MBU is organised into nine independent research groups and includes 30-40 graduate students who are members of the University of Cambridge : Professor Judy Hirst FRS (2020 - ) Professor Massimo Zeviani (2013 - 2019) Professor Sir John Walker FRS (1998 - 2013) Dr Roger Whitehead (1973 – 1998) Dr Egon Kodicek CBE FRS (1963 - 1973) Dr Leslie Harris (1929 - 1963) Sir Frederick Gowland Hopkins (1927 - 1929) School of Clinical Medicine, University of Cambridge The School of Clinical Medicine

630-556: The areas of diabetes, obesity and related metabolic and endocrine diseases. The institute is a joint venture between the University of Cambridge, The Medical Research Council, Cambridge University NHS Hospitals Trust and the Wellcome Trust . It is led by co-directors Professor Sir Stephen O'Rahilly and Professor Nick Wareham . Lead researchers include Krishna Chatterjee , David Dunger , Sadaf Farooqi , Nita Forouhi , Stephen O’Rahilly , Nigel Unwin , Antonio Vidal-Puig , Nick Wareham , and Giles Yeo , among many others. Adjacent to

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660-451: The cohort integrates with A100 students in their 5th year for the final two years of the course. The Clinical School was established in 1976 while construction of the new building at its present site was underway. The clinical course was restructured in 2005 with the addition of a new final year, as the clinical course had previously been less than three years in length. Before 2017, approximately half of medical students left Cambridge after

690-465: The department received an annual budget of £45 million, £27.8 million of which came from Cancer Research UK. The institute offers highly competitive PhD programmes; both studentships and clinical research training fellowships (for aspiring clinical academics), attracting applicants from the UK and around the world. Cancer research is a designated University of Cambridge Strategic Initiative. Research in

720-574: The discovery of the double-helix structure of DNA . The Wellcome Trust- Medical Research Council Cambridge Stem Cell Institute or 'SCI' is a virtual organisation composed of the Anne McLaren Laboratory for Stem Cell Biology and Regenerative Medicine and the Wellcome Trust Centre for Stem Cell Research, as well as University-based Principal Investigators working in neighbouring Cambridge institutes whose research

750-587: The famous physician, into his third year at Addenbrooke’s Hospital, pioneered bedside examinations. Cambridge Biomedical Campus The Cambridge Biomedical Campus is the largest centre of medical research and health science in Europe. The site is located at the southern end of Hills Road in Cambridge , England . Over 20,000 people work at the site, which is home to Cambridge University Hospitals NHS Foundation Trust , Royal Papworth Hospital NHS Foundation Trust , AstraZeneca 's headquarters, Abcam ,

780-619: The pre-clinical component of the combined medical course or as part of the graduate course. The Herchel Smith Laboratory for Medicinal Chemistry is a laboratory under the aegis of the Regius Professor of Physic in the School of Clinical Medicine. The teaching of medicine at the University of Cambridge dates back to 1540 when Henry VIII endowed the University’s first Professorship of Physic, Dr John Blyth. In 1842, George Paget ,

810-471: The pre-clinical course as there were not enough places on the clinical course for them all; common destinations included medical schools based in Oxford, London and Manchester. From 2017, all medical students continue to study in Cambridge for the full six years provided they pass the pre-clinical component of the course. Students enter the clinical course at Cambridge following satisfactory progression during

840-523: The standard A100 course, students typically enter the clinical school on completion of three years of pre-clinical training. Approximately half of clinical training in Cambridge takes place at the Cambridge Biomedical Campus , with the other half located in regional hospitals and general practices across the east of England . The accelerated A101 Graduate Entry Course leads to the award of MB BChir (Doctor of Medicine and Doctor of Surgery) in 4 years, with approximately 40 students in each cohort. This course

870-536: The study of the mitochondrion , as this organelle has a varied and critical role in many aspects of eukaryotic metabolism and is implicated in many metabolic, degenerative, and age-related human diseases. The Unit was founded in 1927 using a donation from Sir William Dunn , who left £1 million to charity on his death in 1912. Part of this money was used to fund what was then called the Dunn Nutritional Laboratory, with its research supported by

900-526: Was created in 1995 to develop and apply advanced imaging methods to patients with traumatic brain injury. It is unique in being co-located with the Neurosciences Critical Care Unit of Addenbrooke's Hospital . Since its establishment it has become an internationally leading Positron Emission Tomography and Magnetic Resonance Imaging centre. The Hutchison/MRC Research Centre is a cancer research centre housing researchers from

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