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66-516: Grants are awarded based on the recommendations of NCC's Scientific Advisory Board, which uses National Institutes of Health evaluation standards. Scientific Advisory Board members are cancer research professionals, headed by Dr. Darell Bigner, founder and director of Duke University’s Preston Robert Tisch Brain Tumor Center, the largest brain tumor research facility in the country. Other Grant Review Committee members represent such institutions as

132-471: A certain percentage (2.8% in 2014) must be granted to small businesses under the SBIR/STTR program. As of 2011 , the extramural funding consisted of about 50,000 grants to more than 325,000 researchers at more than 3000 institutions. By 2018 , this rate of granting remained reasonably steady, at 47,000 grants to 2,700 organizations. In FY 2010 , NIH spent US$ 10.7bn (not including temporary funding from

198-508: A clinical trial, except for the most critically ill, as determined by the NIH Director. Over the last century, the responsibility to allocate funding has shifted from the OD and Advisory Committee to the individual ICs and Congress increasingly set apart funding for particular causes. In the 1970s, Congress began to earmark funds specifically for cancer research, and in the 1980s there was

264-1149: A comprehensive psychiatric emergency program), and the center for a mental health client dispersed housing and in-community employment program. In 2000, Sisters of Charity turned over Bayley Seton (along with their main Staten Island hospital) to Saint Vincent's Catholic Medical Center , which already included the Sisters' Manhattan and Westchester County hospitals, to create Saint Vincent's Catholic Medical Centers New York. Facing financial difficulties almost immediately, Bayley saw around half its services closed, including its emergency room, pharmacy, surgery, and most medical clinics. After filing for bankruptcy in 2003, Saint Vincent's spun off or closed almost half its sites, including selling another hospital on Bard Avenue to Bayonne Medical Center , becoming Richmond University Medical Center in 2007. Most psychiatric and addiction services were retained, as were outpatient clinics for geriatrics, patients with HIV infection, military and family health services, and mother and baby care. At

330-631: A deal was struck whereby at the end of 2008, the Salvation Army would purchase the Bayley campus, demolish the main hospital, and build a recreation center. The complex was to be known as the Kroc Center. There was public, political, and press outcry at this plan, especially because Richmond University Medical Center announced it was going to end most operations at Bayley Seton and scale back operations at its main campus. From 2014 to 2019,

396-468: A diverse research portfolio in order to capitalize on major discoveries in a variety of fields such as cell biology, genetics, physics, engineering, and computer science. Fourth, address public health needs according to the disease burden (e.g., prevalence and mortality). And fifth, construct and support the scientific infrastructure (e.g., well-equipped laboratories and safe research facilities) necessary to conduct research. Advisory committee members advise

462-601: A rate similar to inflation since the 1970s, research funding for the NIH nearly tripled through the 1990s and early 2000s, but has remained relatively stagnant since then. By the 1990s, the NIH committee focus had shifted to DNA research and launched the Human Genome Project . The NIH Office of the Director is the central office responsible for setting policy for NIH, and for planning, managing, and coordinating

528-400: A series of audit reports revealing that throughout the fiscal years 2000–2010, institutes under the aegis of the NIH did not comply with the time and amount requirements specified in appropriations statutes, in awarding federal contracts to commercial partners, committing the federal government to tens of millions of dollars of expenditure ahead of appropriation of funds from Congress. The NIH

594-523: A significant amount allocated for AIDS/HIV research. Funding for the NIH has often been a source of contention in Congress, serving as a proxy for the political currents of the time. During the 1980s, President Reagan repeatedly tried to cut funding for research, only to see Congress partly restore funding. The political contention over NIH funding slowed the nation's response to the AIDS epidemic; while AIDS

660-562: A wooden device used to collect cervical cells in women to detect cancer, and a strong advocate for early cancer screening. The National Cancer Center funds these research programs: The Breast Cancer Project, The Children’s Cancer Project, Aggressive Cancer Research, Fighting Childhood Leukemia, and The Prostate Cancer Project. This article about a United States health organization is a stub . You can help Misplaced Pages by expanding it . National Institutes of Health The National Institutes of Health , commonly referred to as NIH ,

726-613: Is available to the general public whereas the individual-level data is accessible to researchers. According to the City Journal NIH denies access to such attributes as intelligence, education and health on the grounds that studying their genetic basis would be stigmatizing. The NIH partnered with Moderna in 2020 during the COVID-19 pandemic to develop a vaccine. The final phase of testing began on July 27 with up to 30,000 volunteers assigned to one of two groups—one receiving

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792-612: Is composed of 27 separate institutes and centers that conduct and coordinate biomedical research. These are: In addition, the National Center for Research Resources operated from April 13, 1962, to December 23, 2011. The Advanced Research Projects Agency for Health (ARPA-H) is an entity formerly within the Office of the United States Secretary of Health and Human Services , which was created by Congress in

858-443: Is determined by the scientist. The total number of applicants has increased substantially, from about 60,000 investigators who had applied during the period from 1999 to 2003 to slightly less than 90,000 in who had applied during the period from 2011 to 2015. Due to this, the "cumulative investigator rate", that is, the likelihood that unique investigators are funded over a 5-year window, has declined from 43% to 31%. R01 grants are

924-520: Is requesting $ 2.5 billion for 2024. Source: Bayley Seton Hospital Bayley Seton Hospital (BSH) was a hospital in Stapleton , Staten Island , New York City . It was a part of the Bayley Seton campus of Richmond University Medical Center but is permanently closed. The campus was established in 1831 as a U.S Marine Hospital , and the current main building was constructed in

990-856: Is the primary agency of the United States government responsible for biomedical and public health research. It was founded in 1887 and is now part of the United States Department of Health and Human Services . Many NIH facilities are located in Bethesda, Maryland , and other nearby suburbs of the Washington metropolitan area , with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around

1056-597: The American Recovery and Reinvestment Act of 2009 ) on clinical research , US$ 7.4bn on genetics -related research, US$ 6.0bn on prevention research, US$ 5.8bn on cancer, and US$ 5.7bn on biotechnology . In 2008 a Congressional mandate called for investigators funded by the NIH to submit an electronic version of their final manuscripts to the National Library of Medicine 's research repository, PubMed Central (PMC), no later than 12 months after

1122-509: The Consolidated Appropriations Act, 2022 . Modeled after DARPA , HSARPA , IARPA , and ARPA-E , it is intended to pursue unconventional research projects through methods not typically used by federal agencies or private sector companies. Secretary Xavier Becerra delegated ARPA-H to the NIH on May 24, 2022. It received $ 1 billion in appropriations in 2022, and $ 1.5 billion in 2023, and as of June 2023 it

1188-595: The Dana-Farber Cancer Institute , the University of Pittsburgh Cancer Institute and Duke University Medical Center . The Center's funding of basic research epitomizes the high standards of founder Dr. James Ernest Ayre. Dr. James Ernest Ayre was a ground-breaking gynecologist dedicated to cancer research by ways of immunology and cytology detection. He was the co-inventor of the Ayre spatula ,

1254-697: The Hygienic Laboratory , was established within the Marine Hospital Service , which at the time was expanding its functions beyond the system of Marine Hospitals into quarantine and research programs. It was initially located at the New York Marine Hospital on Staten Island . In 1891, it moved to the top floor of the Butler Building in Washington, D.C. In 1904, it moved again to a new campus at

1320-775: The Old Naval Observatory , which grew to include five major buildings. In 1901, the Division of Scientific Research was formed, which included the Hygienic Laboratory as well as other research offices of the Marine Hospital Service. In 1912, the Marine Hospital Service became the Public Health Service (PHS). In 1922, PHS established a Special Cancer Investigations laboratory at Harvard Medical School . This marked

1386-641: The Second World War assured a large military and veteran population for the hospital. In 1980, President Ronald Reagan announced plans to close or sell all such hospitals, and despite local protest, Staten Island Public Health Service Hospital was sold to the Sisters of Charity of New York , a Catholic medical and social services system. The Sisters of Charity renamed the hospital Bayley Seton, after their order's founder, Elizabeth Ann Seton . The renamed hospital expanded its campus buildings to include

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1452-692: The Wuhan Institute of Virology (WIV)—which has been at the center of speculation since early 2020 that SARS-CoV-2 may have escaped in a lab incident. Under political pressure, the NIH withdrew funding to EcoHealth Alliance in July 2020. On February 13, 2012, the National Institutes of Health (NIH) announced a new group of individuals assigned to research pain. This committee is composed of researchers from different organizations and will focus to "coordinate pain research activities across

1518-568: The mRNA-1273 vaccine and the other receiving salt water injections—and continued until there had been approximately 100 cases of COVID-19 among the participants. In 2021, the NIH contributed $ 4,395,399 towards the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program. Following the outbreak of the COVID-19 pandemic , NIH-funded EcoHealth Alliance has been the subject of controversy and increased scrutiny due to its ties to

1584-654: The 1930s. In 1981, it became a private hospital. Bayley Seton is located on a 20-acre (81,000 m ), 12-building site in the Clifton and Stapleton areas of the North Shore of the New York City Borough of Staten Island . The complex is bounded by Bay Street to the east, Vanderbilt Avenue to the south, Tompkins Avenue to the west, and residential development to the north. The block, with portions sold off over time, also includes Public School 721,

1650-577: The 21 drugs with the highest therapeutic impact on society introduced between 1965 and 1992, public funding was "instrumental" for 15. As of 2011 NIH-supported research helped to discover 153 new FDA-approved drugs, vaccines, and new indications for drugs in the 40 years prior. One study found NIH funding aided either directly or indirectly in developing the drugs or drug targets for all of the 210 FDA-approved drugs from 2010 to 2016. In 2015, Pierre Azoulay et al. estimated $ 10 million invested in research generated two to three new patents. Since its inception,

1716-826: The Center for Cancer Research, Office of Scientific Operations, Management Operations Support Branch, the division of Cancer Epidemiology and Genetics and the division of Cancer Treatment and Diagnosis. The National Institute of Environmental Health Sciences is located in the Research Triangle region of North Carolina . Other ICs have satellite locations in addition to operations at the main campus. The National Institute of Allergy and Infectious Diseases maintains its Rocky Mountain Labs in Hamilton, Montana , with an emphasis on BSL3 and BSL4 laboratory work. NIDDK operates

1782-772: The Director. NIH submits its budget request to the Department of Health and Human Services (HHS), and the HHS considers this request as a portion of its budget. Many adjustments and appeals occur between NIH and HHS before the agency submits NIH's budget request to the Office of Management and Budget (OMB). OMB determines what amounts and research areas are approved for incorporation into the President's final budget. The President then sends NIH's budget request to Congress in February for

1848-490: The Jewish Chronic Disease Hospital. When three doctors resigned after refusing to inject patients without their consent, the experiment gained considerable media attention. The NIH was a major source of funding for Southam's research and had required all research involving human subjects to obtain their consent prior to any experimentation. Upon investigating all of their grantee institutions,

1914-560: The NIH Toolbox was rolled out to the research community. NIH Toolbox assessments are based, where possible, on Item Response Theory and adapted for testing by computer. NIH sponsors the Database of Genotypes and Phenotypes (dbGaP), a repository of information produced by studies investigating the interaction of genotype and phenotype. The information includes phenotypes, molecular assay data, analyses and documents. Summary-level data

1980-461: The NIH budget doubled. For a time, funding essentially remained flat, and for seven years following the financial crisis, the NIH budget struggled to keep up with inflation. In 1999 Congress increased the NIH's budget by $ 2.3 billion to $ 17.2 billion in 2000. In 2009 Congress again increased the NIH budget to $ 31 billion in 2010. In 2017 and 2018, Congress passed laws with bipartisan support that substantially increasing appropriations for NIH, which

2046-437: The NIH but may apply for funding. Throughout the history of the NIH, the amount of funding received has increased, but the proportion to each IC remains relatively constant. The individual ICs then decide who will receive the grant money and how much will be allotted. Policy changes on who receives funding significantly affect researchers. For example, the NIH has recently attempted to approve more first-time NIH R01 applicants or

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2112-476: The NIH discovered that the majority of them did not protect the rights of human subjects. From then on, the NIH has required all grantee institutions to approve any research proposals involving human experimentation with review boards. In 1967, the Division of Regional Medical Programs was created to administer grants for research for heart disease, cancer, and strokes . That same year, the NIH director lobbied

2178-429: The NIH has often been a source of contention in Congress, serving as a proxy for the political currents of the time. In 1992, the NIH encompassed nearly 1 percent of the federal government's operating budget and controlled more than 50 percent of all funding for health research, and 85 percent of all funding for health studies in universities. While government funding for research in other disciplines has been increasing at

2244-670: The NIH intramural research program has been a source of many pivotal scientific and medical discoveries. Some of these include: In September 2006, the NIH Blueprint for Neuroscience Research started a contract for the NIH Toolbox for the Assessment of Neurological and Behavioral Function to develop a set of state-of-the-art measurement tools to enhance collection of data in large cohort studies. Scientists from more than 100 institutions nationwide contributed. In September 2012,

2310-453: The NIH would take the balance of each study design into consideration when awarding grants. The announcement also stated that this rule would probably not apply when studying sex-specific diseases (for example, ovarian or testicular cancer). One of the goals of the NIH is to "expand the base in medical and associated sciences in order to ensure a continued high return on the public investment in research." Taxpayer dollars funding NIH are from

2376-492: The National Institute for General Medical Science awarded funding to 30% of applicants. NIH employs five broad decision criteria in its funding policy. First, ensure the highest quality of scientific research by employing an arduous peer review process. Second, seize opportunities that have the greatest potential to yield new knowledge and that will lead to better prevention and treatment of disease. Third, maintain

2442-565: The Phoenix Epidemiology and Clinical Research Branch in Phoenix, Arizona . As of 2017, 153 scientists receiving financial support from the NIH have been awarded a Nobel Prize and 195 have been awarded a Lasker Award . NIH devotes 10% of its funding to research within its own facilities (intramural research), and gives >80% of its funding in research grants to extramural (outside) researchers. Of this extramural funding,

2508-729: The Richmond Center for Rehab & Specialty Care Center, the New York Foundling Hospital Staten Island, and an unaffiliated geriatric center. On October 1, 1831, Staten Island's first hospital, the Seaman's Retreat, was opened here by the Marine Hospital Service , to serve retired naval and commercial sailors. Three of these original colonnaded structures remain as of 2024 , dating from the 1830s and 1840s. The Marine Hospital Service provided medical treatment to naval personnel. On May 6, 1857,

2574-689: The Saint Elizabeth Ann outpatient clinics, and turned over part of the campus to the New York Foundling Hospital . In the 1990s Amethyst House , a women's Drug Abuse Treatment center was opened, as well as an Alcoholism Acute Care Unit on the 3rd floor, a St. Vincent's Nursing School on the fifth floor, social service agencies in other buildings, including the Richmond Center for Rehab & Specialty Care Center, hospital inpatient drug rehab treatment services, services for co-occurring mental and substance abuse disorders,

2640-474: The South Shore of Staten Island, about 2.5 miles (4.0 km) south of Fort Wadsworth ). In 1874, some of these resources were transferred to the Marine Hospital Service buildings at what is now the Bayley Seton campus. The Seaman's Retreat was also housed there; when it moved around three miles (5 km) northwest in 1883, it became Sailors' Snug Harbor . At that point, the entire complex was operated by

2706-532: The TV series Gotham used the hospital as a setting for interior and exterior scenes set in Arkham Asylum . The Amazon series Hunters also used the campus for filming. Many films have shot on the campus including "The Adjustment Bureau", "Salt", "Terrifier 2" and the locally shot comedy "Abnormal Attraction" starring Malcolm McDowell, Bruce Davison, Gilbert Gottfried , and Leslie Easterbrook. As of 2020,

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2772-566: The U.S. Marine Hospital Service. With this move came a greater need for the study of disease. In 1887, 28-year-old officer Joseph J. Kinyoun established a single-room Laboratory of Hygiene for Bacteriological Investigation on the top floor of the Marine Hospital, where it remained until 1891. The building still stands and is part of Bayley Seton Hospital. In 1902, the United States Congress passed legislation to fund

2838-635: The United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program. As of 2013 , the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in

2904-649: The White House for increased federal funding in order to increase research and the speed with which health benefits could be brought to the people. An advisory committee was formed to oversee the further development of the NIH and its research programs. By 1971 cancer research was in full force and President Nixon signed the National Cancer Act , initiating a National Cancer Program, President's Cancer Panel, National Cancer Advisory Board, and 15 new research, training, and demonstration centers. Funding for

2970-415: The beginning of 2008, Saint Vincent's Catholic Medical Centers and Richmond University Medical Center negotiated a deal to share Bayley Seton. As of 2007 , there were an estimated 1,500 patients who used the Bayley Seton facilities regularly, and as of 2004, the hospital employed approximately 550 staff, just more than half the 990 employed in 2000. Six smaller buildings were closed, staff consolidated, and

3036-567: The beginning of a partnership with universities. In 1930, the Hygienic Laboratory was re-designated as the National Institute of Health by the Ransdell Act , and was given $ 750,000 to construct two NIH buildings at the Old Naval Observatory campus. In 1937, NIH absorbed the rest of the Division of Scientific Research, of which it was formerly part. In 1938, NIH moved to its current campus in Bethesda, Maryland . Over

3102-473: The creation of vaccines against hepatitis , Haemophilus influenzae (HIB), and human papillomavirus (HPV). In 2019, the NIH was ranked number two in the world, behind Harvard University , for biomedical sciences in the Nature Index , which measured the largest contributors to papers published in a subset of leading journals from 2015 to 2018. In 1887, a laboratory for the study of bacteria,

3168-522: The federal government with the goals of stimulating pain research collaboration… and providing an important avenue for public involvement" ("Members of new", 2012). With a committee such as this research will not be conducted by each individual organization or person but instead a collaborating group which will increase the information available. With this hopefully more pain management will be available including techniques for those with arthritis. In 2020 Beth Darnall , American scientist and pain psychologist,

3234-489: The institute on policy and procedures affecting the external research programs and provide a second level of review for all grant and cooperative agreement applications considered by the Institute for funding. In 2014, it was announced that the NIH is directing scientists to perform their experiments with both female and male animals, or cells derived from females as well as males if they are studying cell cultures, and that

3300-581: The laboratory and move it to Washington where, as a result of the 1930 Ransdell Act , it became the National Institutes of Health . In the 1930s, President Franklin Roosevelt began a campaign to construct and maintain U.S. Public Health Service Hospitals , to serve the military, veterans, and the general public. As part of this process, the current main building of Bayley Seton was constructed. The Staten Island Public Health Service Hospital

3366-463: The main hospital building was still in operation at reduced capacity. The Salvation Army had purchased a seven-acre portion of the campus with the intention of redeveloping the site into senior housing or a community center. However, the organization sold the building years ago before funds could be raised to proceed with the project. Buildings on that portion of the campus were demolished in 2018. Centers Plan for Healthy Living (CPHL) In 2012,

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3432-530: The most common funding mechanism and include investigator-initiated projects. The roughly 27,000 to 29,000 R01 applications had a funding success of 17-19% during 2012 though 2014. Similarly, the 13,000 to 14,000 R21 applications had a funding success of 13-14% during the same period. In FY 2016, the total number of grant applications received by the NIH was 54,220, with approximately 19% being awarded funding. Institutes have varying funding rates. The National Cancer Institute awarded funding to 12% of applicants, while

3498-574: The neighboring New York Marine Hospital (also the "Quarantine") in Tompkinsville , about 1 mile (1.6 km) north along the shore, was attacked by a local mob, fearful of the mostly immigrant detainees. The next year, on September 1, 1858, a mob again attacked the hospital, burning it down in what became known as the Staten Island Quarantine War . A new quarantine center was created on Swinburne Island (a fill off

3564-653: The next few decades, Congress would markedly increase funding of the NIH, and various institutes and centers within the NIH were created for specific research programs. In 1944, the Public Health Service Act was approved, and the National Cancer Institute became a division of NIH. In 1948, the name changed from National Institute of Health to National Institutes of Health. In the 1960s, virologist and cancer researcher Chester M. Southam injected HeLa cancer cells into patients at

3630-466: The next fiscal year's allocations. The House and Senate Appropriations Subcommittees deliberate and by fall, Congress usually appropriates funding. This process takes approximately 18 months before the NIH can allocate any actual funds. When a government shutdown occurs, the NIH continues to treat people who are already enrolled in clinical trials , but does not start any new clinical trials and does not admit new patients who are not already enrolled in

3696-539: The official date of publication. The NIH Public Access Policy was the first public access mandate for a U.S. public funding agency. In 2000, the Joint Economic Committee of Congress reported NIH research, which was funded at $ 16 billion a year in 2000, that some econometric studies had given a rate of return of 25 to 40 percent per year by reducing the economic cost of illness in the US. It found that of

3762-599: The programs and activities of all NIH components. The NIH Director plays an active role in shaping the agency's activities and outlook. The Director is responsible for providing leadership to the Institutes and Centers by identifying needs and opportunities, especially in efforts involving multiple Institutes. Within the Director's Office is the Division of Program Coordination, Planning and Strategic Initiatives with 12 divisions including: The Agency Intramural Research Integrity Officer "is directly responsible for overseeing

3828-468: The research grant applications of young scientists. To encourage the participation of young scientists, the application process has been shortened and made easier. In addition, first-time applicants are being offered more funding for their research grants than those who have received grants in the past. In 2011 and 2012, the Department of Health and Human Services Office of Inspector General published

3894-517: The resolution of all research misconduct allegations involving intramural research , and for promoting research integrity within the NIH Office of Intramural Research (OIR)." There is a Division of Extramural Activities, which has its own Director. The Office of Ethics has its own Director, as does the Office of Global Research. Intramural research is primarily conducted at the main campus in Bethesda, Maryland , and Rockville, Maryland , and

3960-437: The surrounding communities. The Bayview Campus in Baltimore , Maryland houses the research programs of the National Institute on Aging , National Institute on Drug Abuse , and National Human Genome Research Institute with nearly 1,000 scientists and support staff. The Frederick National Laboratory in Frederick, MD and the nearby Riverside Research Park, houses many components of the National Cancer Institute , including

4026-533: The taxpayers, making them the primary beneficiaries of advances in research. Thus, the general public is a key stakeholder in the decisions resulting from the NIH funding policy. However, some in the general public do not feel their interests are being represented, and individuals have formed patient advocacy groups to represent their own interests. Important stakeholders of the NIH funding policy include researchers and scientists. Extramural researchers differ from intramural researchers in that they are not employed by

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4092-414: The world, while, as of 2003, the extramural arm provided 28% of biomedical research funding spent annually in the U.S., or about US$ 26.4 billion. The NIH comprises 27 separate institutes and centers of different biomedical disciplines and is responsible for many scientific accomplishments, including the discovery of fluoride to prevent tooth decay , the use of lithium to manage bipolar disorder , and

4158-617: Was 37.3 billion dollars annually in FY2018. Researchers at universities or other institutions outside of NIH can apply for research project grants (RPGs) from the NIH. There are numerous funding mechanisms for different project types (e.g., basic research, clinical research, etc.) and career stages (e.g., early career, postdoc fellowships, etc.). The NIH regularly issues "requests for applications" (RFAs), e.g., on specific programmatic priorities or timely medical problems (such as Zika virus research in early 2016). In addition, researchers can apply for "investigator-initiated grants" whose subject

4224-455: Was appointed as scientific member of the group. To allocate funds, the NIH must first obtain its budget from Congress. This process begins with institute and center (IC) leaders collaborating with scientists to determine the most important and promising research areas within their fields. IC leaders discuss research areas with NIH management who then develops a budget request for continuing projects, new research proposals, and new initiatives from

4290-405: Was built as a five- to seven-story hospital, in a Mayan revival style. Until 1981, it operated inpatient and outpatient services, emergency, surgery, and rehabilitation wards. Military installations at Fort Wadsworth , Fort Hamilton (just across the narrows in Brooklyn ), the Staten Island Homeport , Miller Field Air Station , as well as air, naval and Coast Guard installations built during

4356-576: Was reported in newspaper articles from 1981, no funding was provided for research on the disease. In 1984 National Cancer Institute scientists found implications that "variants of a human cancer virus called HTLV-III are the primary cause of acquired immunodeficiency syndrome (AIDS)," a new epidemic that gripped the nation. In 1992, the NIH encompassed nearly 1 percent of the federal government's operating budget and controlled more than 50 percent of all funding for health research and 85 percent of all funding for health studies in universities. From 1993 to 2001

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