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110-559: Symrise was founded in 2003 by the merger of Bayer subsidiary Haarmann & Reimer (H&R) and Dragoco, both based in Holzminden, Germany . Haarman & Reimer (H&R) was founded in 1874 by chemists Ferdinand Tiemann and Wilhelm Haarmann after they succeeded in first synthesizing vanillin from coniferin . Holzminden was the site where vanillin was first produced industrially. In 1917, H&R supported Leopold Ružička 's unsuccessful three-year project to synthesize irone ,

220-400: A maintenance drug to assist the treatment of opiate addiction, normally in long-term chronic intravenous (IV) heroin users. It is only prescribed following exhaustive efforts at treatment via other means. It is sometimes thought that heroin users can walk into a clinic and walk out with a prescription, but the process takes many weeks before a prescription for diamorphine is issued. Though this

330-488: A prodrug for the systemic delivery of morphine. When the drug is injected, however, it avoids this first-pass effect, very rapidly crossing the blood–brain barrier because of the presence of the acetyl groups, which render it much more fat soluble than morphine itself. Once in the brain, it then is deacetylated variously into the inactive 3-monoacetylmorphine and the active 6-monoacetylmorphine (6-MAM), and then to morphine, which bind to μ-opioid receptors , resulting in

440-408: A rush as a forerunner to the high experienced with the use of heroin, which is most pronounced with intravenous use. While the onset of the rush induced by injection can occur in as little as a few seconds, the oral route of administration requires approximately half an hour before the high sets in. Thus, with both higher the dosage of heroin used and faster the route of administration used, the higher

550-431: A German conglomerate formed from the merger of six chemical companies: BASF , Bayer , Hoechst (including Cassella and Kalle & Co.  [ de ] ), Agfa , Chemische Fabrik Griesheim-Elektron, and Chemische Fabrik vorm. Weiler Ter Meer . In the 1930s, Gerhard Domagk , director of Bayer's Institute of Pathology and Bacteriology, working with chemists Fritz Mietzsch and Joseph Klarer, discovered prontosil ,

660-474: A fast onset. Snorting heroin becomes an often unwanted route, once a user begins to inject the drug. The user may still get high on the drug from snorting, and experience a nod, but will not get a rush. A "rush" is caused by a large amount of heroin entering the body at once. When the drug is taken in through the nose, the user does not get the rush because the drug is absorbed slowly rather than instantly. Heroin for pain has been mixed with sterile water on site by

770-498: A fee of $ 1.02 billion. In August 2019, the business acquired the ≈60% of BlueRock Therapeutics it didn't already own for up to $ 600 million. In August 2020, Bayer announced it had acquired KaNDy Therapeutics Ltd, helping to boost its female healthcare business, for $ 425 million. In October, Bayer agreed to acquire Asklepios BioPharmaceuticals for $ 2 billion upfront. In June 2021, the company announced it acquire Noria Therapeutics Inc. and PSMA Therapeutics Inc. gaining rights to

880-539: A few addicts who have tried methadone and buprenorphine without success. Beginning in February 2010, addicts in Copenhagen and Odense became eligible to receive free diamorphine. Later in 2010, other cities including Århus and Esbjerg joined the scheme. It was estimated that around 230 addicts would be able to receive free diamorphine. However, Danish addicts would only be able to inject heroin according to

990-666: A fragrance of violets . In 1953, H&R was acquired by Bayer. Dragoco was founded in 1919 by Carl-Wilhelm Gerberding and his cousin August Bellmer. Horst-Otto Gerberding, majority holder and Chairman of the Executive Board at Dragoco, placed all of his shares into the new Syrmise corporation and the merger was completed May 23, 2003. In April 2005, Symrise acquired Flavours Direct, a UK-based manufacturer of compounded flavours and seasonings. In January 2006, Symrise acquired Hamburg based Kaden Biochemicals GmbH,

1100-559: A history of long-term use, opioid withdrawal symptoms can begin within hours of the last use. When given by injection into a vein, heroin has two to three times the effect of a similar dose of morphine . It typically appears in the form of a white or brown powder. Treatment of heroin addiction often includes behavioral therapy and medications. Medications can include buprenorphine , methadone , or naltrexone . A heroin overdose may be treated with naloxone . As of 2015, an estimated 17 million people use opiates, of which heroin

1210-548: A larger area in Elberfeld in 1866. Friedrich Bayer (1851–1920), the son of the company's founder, was a chemist and joined the company in 1873. After the death of his father in 1880, the company became a joint-stock company, Farbenfabriken vorm. Friedr. Bayer & Co, also known as Elberfelder Farbenfabriken. A further expansion in Elberfeld was impossible, so the company moved to the village Wiesdorf at Rhein and settled in

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1320-469: A law allowing diamorphine prescription as a standard treatment for addicts; a large-scale trial of diamorphine prescription had been authorized in the country in 2002. On 26 August 2016, Health Canada issued regulations amending prior regulations it had issued under the Controlled Drugs and Substances Act ; the "New Classes of Practitioners Regulations", the "Narcotic Control Regulations", and

1430-617: A lung irritant against British forces. In 1916, Bayer scientists discovered suramin , an anti- parasite drug that is still sold by Bayer under the brand name Germanin. The formula of suramin was kept secret by Bayer for commercial reasons, but it was elucidated and published in 1924 by Ernest Fourneau and his team at the Pasteur Institute . It is on the World Health Organization's List of Essential Medicines . In 1925, Bayer became part of IG Farben ,

1540-608: A more common cause of drug-related deaths. Depending on drug interactions and numerous other factors, death from overdose can take anywhere from several minutes to several hours. Death usually occurs due to lack of oxygen resulting from the lack of breathing caused by the opioid. Heroin overdoses can occur because of an unexpected increase in the dose or purity or because of diminished opioid tolerance. However, many fatalities reported as overdoses are probably caused by interactions with other depressant drugs such as alcohol or benzodiazepines . Since heroin can cause nausea and vomiting,

1650-577: A natural product of the opium poppy . Internationally, heroin is controlled under Schedules I and IV of the Single Convention on Narcotic Drugs , and it is generally illegal to make, possess, or sell without a license. About 448 tons of heroin were made in 2016. In 2015, Afghanistan produced about 66% of the world's opium. Illegal heroin is often mixed with other substances such as sugar, starch , caffeine , quinine , or other opioids like fentanyl . Bayer 's original trade name of heroin

1760-405: A number of cancer-based investigational compounds based on actinium-225 . In September 2015, Bayer spun out its $ 12.3 billion materials science division into a separate, publicly traded company called Covestro in which it retained about a 70% interest. Bayer spun out the division because it had relatively low profit margins compared to its life science divisions (10.2%, compared with 24.9% for

1870-499: A period of abstinence. If this occurs and the user takes a dose comparable to their previous use, the user may experience drug effects that are much greater than expected, potentially resulting in an overdose. It has been speculated that an unknown portion of heroin-related deaths are the result of an overdose or allergic reaction to quinine , which may sometimes be used as a cutting agent. When taken orally, heroin undergoes extensive first-pass metabolism via deacetylation , making it

1980-401: A producer of specialty botanical extracts. In November 2006, Symrise announced plans to sell shares worth €650 million in an IPO . The firm also announced that its main shareholders, including EQT, would also sell shares worth an unspecified amount. The IPO would leave well above 50% of Symrise shares in free-float . Deutsche Bank and UBS conducted the listing on December 11, 2006. Symrise

2090-483: A significant number of deaths attributed to heroin overdose are caused by aspiration of vomit by an unconscious person. Some sources quote the median lethal dose (for an average 75 kg opiate-naive individual) as being between 75 and 600 mg. Illicit heroin is of widely varying and unpredictable purity. This means that the user may prepare what they consider to be a moderate dose while actually taking far more than intended. Also, tolerance typically decreases after

2200-471: A trial diamorphine maintenance program for users that had failed multiple withdrawal programs. The aim of this program was to maintain the health of the user by avoiding medical problems stemming from the illicit use of diamorphine. The first trial in 1994 involved 340 users, although enrollment was later expanded to 1000, based on the apparent success of the program. The trials proved diamorphine maintenance to be superior to other forms of treatment in improving

2310-402: A variable single dose range using a hypodermic needle . The dose of heroin used for recreational purposes is dependent on the frequency and level of use. As with the injection of any drug, if a group of users share a common needle without sterilization procedures, blood-borne diseases, such as HIV/AIDS or hepatitis , can be transmitted. The use of a common dispenser for water for the use in

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2420-501: A variety of product lines including Alka-Seltzer , Flintstones vitamins and One-A-Day vitamins, and Cutter insect repellent . Along with the purchase of Cutter, Bayer acquired Cutter's Factor VIII business. Factor VIII, a clotting agent used to treat hemophilia , was produced, at the time, by processing donated blood. In the early days of the AIDS epidemic , people with hemophilia were found to have higher rates of AIDS, and by 1983

2530-442: Is a morphinan opioid substance synthesized from the dried latex of the opium poppy ; it is mainly used as a recreational drug for its euphoric effects. Heroin is used medically in several countries to relieve pain , such as during childbirth or a heart attack, as well as in opioid replacement therapy . Medical-grade diamorphine is used as a pure hydrochloride salt . Various white and brown powders sold illegally around

2640-527: Is a component of the EURO STOXX 50 stock market index. Bayer was founded in 1863 in Barmen as a partnership between dye salesman Friedrich Bayer (1825–1880) and dyer Friedrich Weskott (1821–1876). The company was established as a dyestuffs producer, but the versatility of aniline chemistry led Bayer to expand its business into other areas. In 1899, Bayer launched the compound acetylsalicylic acid under

2750-426: Is an example of a General Medicine business unit. Bayer Pharma produces the birth control pills Yaz and Yasmin . Both pills use a newer type of progestin hormone called drospirenone in combination with estrogen. Yaz is advertised as a treatment for premenstrual dysphoric disorder (PMDD) and moderate acne. Other key products include the cancer drug Nexavar , the multiple sclerosis drug betaferon / betaseron and

2860-466: Is clouded; heart function slows, and breathing is also severely slowed, sometimes enough to be life-threatening. Slowed breathing can also lead to coma and permanent brain damage . Heroin use has also been associated with myocardial infarction . Repeated heroin use changes the physical structure and physiology of the brain, creating long-term imbalances in neuronal and hormonal systems that are not easily reversed. Studies have shown some deterioration of

2970-415: Is heated by a flame underneath it, with the resulting smoke inhaled through a tube of rolled up foil, a method also known as " chasing the dragon ". Another popular route to intake heroin is insufflation (snorting), where a user crushes the heroin into a fine powder and then gently inhales it (sometimes with a straw or a rolled-up banknote , as with cocaine) into the nose, where heroin is absorbed through

3080-418: Is higher than expected. Users report an intense rush , an acute transcendent state of euphoria , which occurs while diamorphine is being metabolized into 6-monoacetylmorphine (6-MAM) and morphine in the brain. Some believe that heroin produces more euphoria than other opioids; one possible explanation is the presence of 6-monoacetylmorphine, a metabolite unique to heroin – although a more likely explanation

3190-498: Is less common than other methods of administration, mainly because there is little to no "rush", and the effects are less potent. Heroin is entirely converted to morphine by means of first-pass metabolism , resulting in deacetylation when ingested. Heroin's oral bioavailability is both dose-dependent (as is morphine's) and significantly higher than oral use of morphine itself, reaching up to 64.2% for high doses and 45.6% for low doses; opiate-naive users showed far less absorption of

3300-691: Is located in St. Louis , Missouri , United States . Bayer CropScience Limited is the Indian subsidiary of Bayer AG. It is listed on the Indian stock exchanges ; the Bombay Stock Exchange and National Stock Exchange of India , and has a market capitalization of $ 2 billion. Bayer BioScience, headquartered in Hyderabad, India , has about 400 employees, and has research, production, and an extensive sales network spread across India . Before

3410-404: Is more fat soluble and therefore more potent by injection, so smaller doses of it are needed for the same effect on pain. Both of these factors are advantageous if giving high doses of opioids via the subcutaneous route, which is often necessary for palliative care. It is also used in the palliative management of bone fractures and other trauma, especially in children. In the trauma context, it

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3520-699: Is more common to use morphine or other strong opioids in these situations. In 2004, the National Institute for Health and Clinical Excellence produced guidance on the management of caesarean section , which recommended the use of intrathecal or epidural diamorphine for post-operative pain relief . For women who have had intrathecal opioids, there should be a minimum hourly observation of respiratory rate, sedation and pain scores for at least 12 hours for diamorphine and 24 hours for morphine. Women should be offered diamorphine (0.3–0.4 mg intrathecally) for intra- and postoperative analgesia because it reduces

3630-415: Is primarily given by nose in hospital; although a prepared nasal spray is available. It has traditionally been made by the attending physician, generally from the same "dry" ampoules as used for injection. In children, Ayendi nasal spray is available at 720 micrograms and 1600 micrograms per 50 microlitres actuation of the spray, which may be preferable as a non-invasive alternative in pediatric care, avoiding

3740-544: Is reduced abruptly. Intravenous use of heroin (and any other substance) with needles and syringes or other related equipment may lead to: The withdrawal syndrome from heroin may begin within as little as two hours of discontinuation of the drug; however, this time frame can fluctuate with the degree of tolerance as well as the amount of the last consumed dose, and more typically begins within 6–24 hours after cessation. Symptoms may include sweating , malaise , anxiety, depression, akathisia , priapism , extra sensitivity of

3850-517: Is somewhat controversial among proponents of a zero-tolerance drug policy , it has proven superior to methadone in improving the social and health situations of addicts. The UK Department of Health's Rolleston Committee Report in 1926 established the British approach to diamorphine prescription to users, which was maintained for the next 40 years: dealers were prosecuted, but doctors could prescribe diamorphine to users when withdrawing. In 1964,

3960-430: Is still sold by Bayer. Other commonly known products initially commercialized by Bayer include heroin , phenobarbital , polyurethanes , and polycarbonates . In 1925, Bayer merged with five other German companies to form IG Farben , creating the world's largest chemical and pharmaceutical company. The first sulfonamide and the first systemically active antibacterial drug, forerunner of antibiotics , Prontosil ,

4070-631: Is the most common, and opioid use resulted in 122,000 deaths; also, as of 2015, the total number of heroin users worldwide is believed to have increased in Africa, the Americas, and Asia since 2000. In the United States, approximately 1.6 percent of people have used heroin at some point. When people die from overdosing on a drug, the drug is usually an opioid and often heroin. Heroin was first made by C. R. Alder Wright in 1874 from morphine,

4180-410: Is the rapidity of onset. While other opioids of recreational use produce only morphine, heroin also leaves 6-MAM, also a psycho- active metabolite . However, this perception is not supported by the results of clinical studies comparing the physiological and subjective effects of injected heroin and morphine in individuals formerly addicted to opioids; these subjects showed no preference for one drug over

4290-450: Is typically used in non-medical settings. It is used as a recreational drug for the euphoria it induces. Anthropologist Michael Agar once described heroin as "the perfect whatever drug." Tolerance develops quickly, and increased doses are needed in order to achieve the same effects. Its popularity with recreational drug users, compared to morphine , reportedly stems from its perceived different effects. Short-term addiction studies by

4400-517: The Brain Committee recommended that only selected approved doctors working at approved specialized centres be allowed to prescribe diamorphine and cocaine to users. The law was made more restrictive in 1968. Beginning in the 1970s, the emphasis shifted to abstinence and the use of methadone; currently, only a small number of users in the UK are prescribed diamorphine. In 1994, Switzerland began

4510-491: The Bundesliga football club Bayer 04 Leverkusen . Bayer AG was founded as a dyestuffs factory in 1863 in Barmen (later part of Wuppertal ), Germany, by Friedrich Bayer and his partner, Johann Friedrich Weskott, a master dyer. Bayer was responsible for the commercial tasks. Fuchsine and aniline became the company's most important products. The headquarters and most production facilities moved from Barmen to

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4620-538: The Commonwealth of Independent States countries such as Russia , Ukraine , Kazakhstan , Belarus , and others. On 28 August 2008, an explosion occurred at the Bayer CropScience facility at Institute, West Virginia , United States . A runaway reaction ruptured a tank and the resulting explosion killed two employees. The ruptured tank was close to a methyl isocyanate tank which was undamaged by

4730-470: The United States between 2013 and 2016. A Bayer spokesperson said that the largest investments will be made to expand the production of its herbicide Liberty. Liberty is an alternative to Monsanto's product, Roundup , which are both used to kill weeds. In 2016, as part of the wholesale corporate restructuring, Bayer CropScience became one of the three major divisions of Bayer AG, reporting directly to

4840-586: The United States , heroin is not accepted as medically useful. Under the generic name diamorphine, heroin is prescribed as a strong pain medication in the United Kingdom , where it is administered via oral , subcutaneous , intramuscular , intrathecal , intranasal or intravenous routes. It may be prescribed for the treatment of acute pain, such as in severe physical trauma , myocardial infarction , post- surgical pain and chronic pain , including end-stage terminal illnesses . In other countries it

4950-505: The east-coast United States is most commonly found in the hydrochloride salt form, requiring just water (and no heat) to dissolve. Users tend to initially inject in the easily accessible arm veins, but as these veins collapse over time, users resort to more dangerous areas of the body, such as the femoral vein in the groin. Some medical professionals have expressed concern over this route of administration, as they suspect that it can lead to deep vein thrombosis . Intravenous users can use

5060-422: The route of administration . Smoking is the fastest route of drug administration, although intravenous injection results in a quicker rise in blood concentration. These are followed by suppository (anal or vaginal insertion), insufflation (snorting), and ingestion (swallowing). A 2002 study suggests that a fast onset of action increases the reinforcing effects of addictive drugs. Ingestion does not produce

5170-667: The "Food and Drug Regulations", to allow doctors to prescribe diamorphine to people who have a severe opioid addiction who have not responded to other treatments. The prescription heroin can be accessed by doctors through Health Canada 's Special Access Programme (SAP) for "emergency access to drugs for patients with serious or life-threatening conditions when conventional treatments have failed, are unsuitable, or are unavailable." Medicinal uses: Neurological: Psychological: Cardiovascular & Respiratory: Gastrointestinal: Musculoskeletal: Skin: Miscellaneous: The onset of heroin's effects depends upon

5280-693: The 2016 restructuring, Bayer HealthCare comprised a further four subdivisions: Bayer Schering Pharma, Bayer Consumer Care, Bayer Animal Health and Bayer Medical Care. As part of the corporate restructuring, Animal Health was moved into its own business unit, leaving the division with the following categories; Allergy, Analgesics, Cardiovascular Risk Prevention, Cough & Cold, Dermatology, Foot Care, Gastrointestinals, Nutritionals and Sun Care. Bayer Consumer Care manages Bayer's OTC medicines portfolio. Key products include analgesics such as Bayer Aspirin and Aleve , food supplements Redoxon and Berocca , and skincare products Bepanthen and Bepanthol. Women's healthcare

5390-678: The Bayer group within IG Farben conducted medical experiments on inmates at Auschwitz and at the Mauthausen concentration camp . In one study of an anaesthetic, the company paid RM 170 per person for the use of 150 female inmates of Auschwitz. A Bayer employee wrote to Rudolf Höss , the Auschwitz commandant: "The transport of 150 women arrived in good condition. However, we were unable to obtain conclusive results because they died during

5500-573: The Belgian biotech company Plant Genetic Systems became part of Bayer through the Aventis acquisition. Also in 2002, Bayer AG acquired the Dutch seed company Nunhems, which at the time was one of the world's top five seed companies. In 2006, the U.S. Department of Agriculture announced that Bayer CropScience's LibertyLink genetically modified rice had contaminated the U.S. rice supply. Shortly after

5610-744: The CDC had identified contaminated blood products as a source of infection. According to the New York Times , this was "one of the worst drug-related medical disasters in history". Companies, including Bayer, developed new ways to treat donated blood with heat to decontaminate it, and these new products were introduced early in 1984. In 1997, Bayer and the other three makers of such blood products agreed to pay $ 660 million to settle cases on behalf of more than 6,000 hemophiliacs infected in United States. But in 2003, documents emerged showing that Cutter had continued to sell unheated blood products in markets outside

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5720-862: The Nobel committee had awarded the 1935 Nobel Peace Prize to a German pacifist, Carl von Ossietzky . IG Farben , Bayer's parent company, used slave labour in factories it built in Nazi concentration camps , most notably in the Monowitz concentration camp (known as Auschwitz III), part of the Auschwitz camp complex in German-occupied Poland. By 1943, almost half of IG Farben's 330,000-strong workforce consisted of slave labour or conscripts, including 30,000 Auschwitz prisoners. Helmuth Vetter , an Auschwitz camp physician, SS captain and employee of

5830-736: The Radiology Business Unit which markets contrast-enhanced diagnostic imaging equipment together with the necessary contrast agents. In addition to internal R&D, Bayer has participated in public–private partnerships . One example in the area of non-clinical safety assessment is the InnoMed PredTox program. Another is the Innovative Medicines Initiative of EFPIA and the European Commission . Bayer Chemicals AG (with

5940-524: The U.S. and Canadian trademark rights to "Bayer" and the Bayer cross, as well as the ownership of the Aspirin trademark in Canada. In 2004, Bayer HealthCare acquired the over-the-counter pharmaceutical division of Roche . In March 2008, Bayer HealthCare announced an agreement to acquire the portfolio and OTC division of privately owned Sagmel, Inc., a US-based company that markets OTC medications in most of

6050-451: The UK. Because significant tolerance to respiratory depression develops quickly with continued use and is lost just as quickly during withdrawal, it is often difficult to determine whether a heroin lethal overdose was accidental, suicide or homicide. Examples include the overdose deaths of Sid Vicious , Janis Joplin , Tim Buckley , Hillel Slovak , Layne Staley , Bradley Nowell , Ted Binion , and River Phoenix . Use of heroin by mouth

6160-565: The US until 1985, including in Malaysia, Singapore, Indonesia, Japan and Argentina, to offload a product they were unable to sell in Europe and the US; they also continued manufacturing the unheated product for several months. Bayer said it did this because some countries were doubtful about the efficacy of the new product. Bayer has been involved in other controversies regarding its drug products. In

6270-472: The United States alone for prevention of cardiovascular events. It is on the WHO Model List of Essential Medicines , the most important medications needed in a basic health system . There is an unresolved controversy over the roles played by Bayer scientists in the development of aspirin. Arthur Eichengrün , a Bayer chemist, said he was the first to discover an aspirin formulation that did not have

6380-471: The United States, Canada and several other countries. In the United States and Canada, Bayer's assets and trademarks, including the well-known Bayer cross, were acquired by Sterling Drug , a predecessor of Sterling Winthrop and were not reclaimed until 1994. Throughout the war, Bayer was involved in production and development of various chemical weapons. In 1914, Bayer manufactured dianisidine chlorosulfate for use in 105 mm artillery shell, intended as

6490-508: The acquisition bid, seeking a higher price. In September 2016, Monsanto agreed to a $ 66 billion offer by Bayer. In order to receive regulatory approval, Bayer agreed to divest a significant amount of its current agricultural assets to BASF in a series of deals. On 21 March 2018 the deal was approved by the European Union, and it was approved in the United States on 20 May 2018. The sale closed on 7 June 2018. The Monsanto brand

6600-403: The acquisition of Diana Group one of the leading manufacturers of natural flavours and the global number 1 for pet food solutions. The transaction was closed on July 29, 2014, and valued at around EUR 1.3 billion of equity and debt. In November 2020, Symrise announced its purchase agreement with Sensient Technologies Corporation, to acquire its fragrance and aroma business. World market share of

6710-803: The agriculture business and 27.5% for healthcare) and because the business required high levels of investment to maintain its growth, and to more clearly focus its efforts and identity in the life sciences. Covestro shares were first offered on the Frankfurt Stock Exchange in October 2015. Effective January 2016 following the spinout of Covestro, Bayer rebranded itself as a life sciences company, and restructured into three divisions and one business unit: Pharmaceuticals, Consumer Health, Crop Science, and Animal Health. In May 2016, Bayer offered to buy U.S. biotechnology company Monsanto for $ 62 billion. Shortly after Bayer's offer, Monsanto rejected

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6820-406: The anus or vagina before the plunger is pushed. The rectum or the vaginal canal is where the majority of the drug would likely be taken up, through the membranes lining their walls. Heroin is classified as a hard drug in terms of drug harmfulness . Like most opioids , unadulterated heroin may lead to adverse effects . The purity of street heroin varies greatly, leading to overdoses when the purity

6930-488: The area of the alizarin producer Leverkus and Sons . A new city, Leverkusen , was founded there in 1930 and became home to Bayer AG's headquarters. The company's corporate logo, the Bayer cross, was introduced in 1904, consisting of the word BAYER written vertically and horizontally, sharing the Y and enclosed in a circle. An illuminated version of the logo is a landmark in Leverkusen. Bayer's first major product

7040-562: The attending physician, and administered using a syringe with a nebulizer tip. Heroin may be used for fractures, burns, finger-tip injuries, suturing, and wound re-dressing, but is inappropriate in head injuries. Little research has been focused on the suppository (anal insertion) or pessary (vaginal insertion) methods of administration, also known as "plugging". These methods of administration are commonly carried out using an oral syringe . Heroin can be dissolved and withdrawn into an oral syringe which may then be lubricated and inserted into

7150-514: The blood-clotting drug, Kogenate . In May 2014, it was announced that Bayer would buy Merck & Co 's consumer health care unit for $ 14.2 billion. Bayer also controls Dihon Pharmaceutical Group Co., Ltd in China. The Pharmaceuticals Division focuses on prescription products, especially for women's healthcare and cardiology , and also on specialty therapeutics in the areas of oncology , hematology and ophthalmology . The division also comprises

7260-438: The brain's white matter due to heroin use, which may affect decision-making abilities, the ability to regulate behavior, and responses to stressful situations. Heroin also produces profound degrees of tolerance and physical dependence. Tolerance occurs when more and more of the drug is required to achieve the same effects. With physical dependence , the body adapts to the presence of the drug , and withdrawal symptoms occur if use

7370-541: The confiscation of Bayer's US assets and trademarks during World War I by the United States, and because of the subsequent widespread usage of the word. The term aspirin continued to be used in the US , UK and France for all brands of the drug, but it is still a registered trademark of Bayer in over 80 countries, including Canada, Mexico, Germany and Switzerland . As of 2011, approximately 40,000 tons of aspirin were produced each year and 10–20 billion tablets consumed in

7480-576: The deal is considered one of the worst corporate mergers in history. By 2023, Bayer's market value had declined by over 60% since its 2016 merger, leaving the company's overall worth at less than half of what it paid to acquire Monsanto. In 2003, to separate operational and strategic managements, Bayer AG was reorganized into a holding company . The group's core businesses were transformed into limited companies, each controlled by Bayer AG . These companies were: Bayer CropScience AG; Bayer HealthCare AG; Bayer MaterialScience AG and Bayer Chemicals AG, and

7590-501: The discovery of phenobarbital in 1911 and the discovery of its potent anti-epileptic activity in 1912. Phenobarbital was among the most widely used drugs for the treatment of epilepsy through the 1970s, and as of 2014 it remains on the World Health Organization's list of essential medications. During World War I (1914–1918), Bayer's assets, including the rights to its name and trademarks, were confiscated in

7700-642: The drug at low doses, having bioavailabilities of only up to 22.9%. The maximum plasma concentration of morphine following oral administration of heroin was around twice as much as that of oral morphine. Injection , also known as "slamming", "banging", "shooting up", "digging" or "mainlining", is a popular method which carries relatively greater risks than other methods of administration. Heroin base (commonly found in Europe), when prepared for injection, will only dissolve in water when mixed with an acid (most commonly citric acid powder or lemon juice) and heated. Heroin in

7810-483: The drug to have "too complicated a name" so Bayer settled on heroisch, the German word for heroic. In 1903, Bayer licensed the patent for the hypnotic drug diethylbarbituric acid from its inventors Emil Fischer and Joseph von Mering. It was marketed under the trade name Veronal as a sleep aid beginning in 1904. Systematic investigations of the effect of structural changes on potency and duration of action at Bayer led to

7920-400: The effects of heroin and causes an immediate return of consciousness but may result in withdrawal symptoms. The half-life of naloxone is shorter than some opioids, such that it may need to be given multiple times until the opioid has been metabolized by the body. Between 2012 and 2015, heroin was the leading cause of drug-related deaths in the United States. Since then, fentanyl has been

8030-595: The exception of H.C. Starck and Wolff Walsrode) was combined with certain components of the polymers segment to form the new company Lanxess on 1 July 2004; Lanxess was listed on the Frankfurt Stock Exchange in early 2005. Bayer HealthCare's Diagnostics Division was acquired by Siemens Medical Solutions in January 2007. Bayer sold its Animal Health business to Elanco in 2020. Heroin Heroin , also known as diacetylmorphine and diamorphine among other names,

8140-473: The experiments. We would kindly request that you send us another group of women to the same number and at the same price." After the war, the Allied Control Council seized IG Farben for "knowingly and prominently ... building up and maintaining German war potential". It was split into its six constituent companies in 1951, then split again into three: BASF, Bayer and Hoechst. Bayer

8250-513: The explosion. In March 2006, Merck KGaA announced a €14.6 billion bid for Schering AG , founded in 1851. By 2006, Schering had annual gross revenue of around €5 billion and employed about 26,000 people in 140 subsidiaries worldwide. Bayer responded with a white knight bid and in July acquired the majority of shares of Schering for €14.6 billion, and in 2007, Bayer took over Schering AG and formed Bayer Schering Pharma. The acquisition of Schering

8360-495: The fear of injection in children. A number of European countries prescribe heroin for treatment of heroin addiction . The initial Swiss HAT ( heroin-assisted treatment ) trial ("PROVE" study) was conducted as a prospective cohort study with some 1,000 participants in 18 treatment centers between 1994 and 1996, at the end of 2004, 1,200 patients were enrolled in HAT in 23 treatment centers across Switzerland. Diamorphine may be used as

8470-579: The first commercially available antibacterial drug. The discovery and development of this first sulfonamide drug opened a new era in medicine. Domagk won the Nobel Prize in Physiology or Medicine in 1939 "for the discovery of the antibacterial effects of prontosil". He was forced by the Nazi Party to relinquish the reward; German citizens had been forbidden from accepting Nobel prizes since

8580-424: The first neuroleptic ( chlorpromazine ) onto the German market. In the 1960s, Bayer introduced a pregnancy test, Primodos , that consisted of two pills that contained norethisterone (as acetate) and ethinylestradiol . It detected pregnancy by inducing menstruation in women who were not pregnant; the presence or absence of menstrual bleeding was then used to determine whether the user was pregnant. The test became

8690-478: The four core units, as depicted below. Bayer CropScience has products in crop protection (i.e. pesticides ), nonagricultural pest control, and seeds and plant biotechnology . In addition to conventional agrochemical business, it is involved in genetic engineering of food . In 2002, Bayer AG acquired Aventis (now part of Sanofi ) CropScience and fused it with their own agrochemicals division (Bayer Pflanzenschutz or "Crop Protection") to form Bayer CropScience;

8800-429: The genitals in females, general feeling of heaviness, excessive yawning or sneezing, rhinorrhea , insomnia , cold sweats, chills, severe muscle and bone aches, nausea, vomiting, diarrhea, cramps, watery eyes, fever, cramp-like pains, and involuntary spasms in the limbs (thought to be an origin of the term "kicking the habit" ). Heroin overdose is usually treated with the opioid antagonist naloxone . This reverses

8910-518: The head of the division, Liam Condon. Under the terms of the merger, Bayer promised to maintain Monsanto's more than 9,000 U.S. jobs and add 3,000 new U.S. high-tech positions. The prospective merger parties said at the time the combined agriculture business planned to spend $ 16 billion on research and development over the next six years and at least $ 8 billion on research and development in the United States. The global headquarters of Bayer CropScience

9020-437: The late 1990s it introduced a statin drug, Baycol ( cerivastatin ), but after 52 deaths were attributed to it, Bayer discontinued it in 2001. The side effect was rhabdomyolysis , causing kidney failure , which occurred with a tenfold greater frequency in patients treated with Baycol in comparison to those prescribed alternate medications of the statin class. Trasylol ( aprotinin ), used to control bleeding during major surgery,

9130-404: The need for supplemental analgesia after a caesarean section. Epidural diamorphine (2.5–5 mg) is a suitable alternative. Diamorphine continues to be widely used in palliative care in the UK, where it is commonly given by the subcutaneous route, often via a syringe driver if patients cannot easily swallow morphine solution . The advantage of diamorphine over morphine is that diamorphine

9240-462: The other. Equipotent injected doses had comparable action courses, with no difference in subjects' self-rated feelings of euphoria, ambition, nervousness, relaxation, drowsiness, or sleepiness. The rush is usually accompanied by a warm flushing of the skin, dry mouth, and a heavy feeling in the extremities. Nausea , vomiting , and severe itching may also occur. After the initial effects, users usually will be drowsy for several hours; mental function

9350-485: The policy set by Danish National Board of Health . Of the estimated 1500 drug users who did not benefit from the then-current oral substitution treatment, approximately 900 would not be in the target group for treatment with injectable diamorphine, either because of "massive multiple drug abuse of non-opioids" or "not wanting treatment with injectable diamorphine". In July 2009, the German Bundestag passed

9460-409: The potential risk for psychological dependence / addiction . Large doses of heroin can cause fatal respiratory depression, and the drug has been used for suicide or as a murder weapon. The serial killer Harold Shipman used diamorphine on his victims, and the subsequent Shipman Inquiry led to a tightening of the regulations surrounding the storage, prescribing and destruction of controlled drugs in

9570-500: The preparation of the injection, as well as the sharing of spoons and filters can also cause the spread of blood-borne diseases. Many countries now supply small sterile spoons and filters for single use in order to prevent the spread of disease. Smoking heroin refers to vaporizing it to inhale the resulting fumes, rather than burning and inhaling the smoke. It is commonly smoked in glass pipes made from glassblown Pyrex tubes and light bulbs. Heroin may be smoked from aluminium foil that

9680-518: The public learned of the contamination, the E.U. banned imports of U.S. long-grain rice and the futures price plunged. In April 2010, a Lonoke County, Arkansas jury awarded a dozen farmers $ 48 million. The case was appealed to the Arkansas Supreme Court, which affirmed the judgement. On 1 July 2011, Bayer CropScience agreed to a global settlement for up to $ 750 million. In September 2014, the firm announced plans to invest $ 1 billion in

9790-625: The relevant fragrance and flavor market (2015) Source: Bayer Bayer AG ( English: / ˈ b aɪ . ər / , commonly pronounced / ˈ b eɪ ər / ; German: [ˈbaɪɐ] ) is a German multinational pharmaceutical and biotechnology company and is one of the largest pharmaceutical companies and biomedical companies in the world. Headquartered in Leverkusen , Bayer's areas of business include: pharmaceuticals, consumer healthcare products, agricultural chemicals , seeds and biotechnology products. The company

9900-529: The route of administration is most commonly intravenous injection ; it may also be given by intramuscular or subcutaneous injection, as well as orally in the form of tablets. The onset of effects is usually rapid and lasts for a few hours. Common side effects include respiratory depression (decreased breathing), dry mouth, drowsiness, impaired mental function, constipation, and addiction . Use by injection can also result in abscesses , infected heart valves , blood-borne infections , and pneumonia . After

10010-521: The same researchers demonstrated that tolerance developed at a similar rate to both heroin and morphine. When compared to the opioids hydromorphone , fentanyl , oxycodone , and pethidine (meperidine), former addicts showed a strong preference for heroin and morphine, suggesting that heroin and morphine are particularly susceptible to misuse and causing dependence. Morphine and heroin were also much more likely to produce euphoria and other positive subjective effects when compared to these other opioids. In

10120-444: The social and health situation for this group of patients. It has also been shown to save money, despite high treatment expenses, as it significantly reduces costs incurred by trials, incarceration, health interventions and delinquency . Patients appear twice daily at a treatment center, where they inject their dose of diamorphine under the supervision of medical staff. They are required to contribute about 450 Swiss francs per month to

10230-427: The soft tissue in the mucous membrane of the sinus cavity and straight into the bloodstream. This method of administration redirects first-pass metabolism , with a quicker onset and higher bioavailability than oral administration, though the duration of action is shortened. This method is sometimes preferred by users who do not want to prepare and administer heroin for injection or smoking but still want to experience

10340-553: The subject of controversy when it was blamed for birth defects , and it was withdrawn from the market in the mid-1970s. Litigation in the 1980s ended inconclusively. A review of the matter by the Medicines and Healthcare products Regulatory Agency in 2014 assessed the studies performed to date and found the evidence for adverse effects to be inconclusive. In 1978, Bayer purchased Miles Laboratories and its subsidiaries Miles Canada and Cutter Laboratories , acquiring along with them

10450-411: The three service limited companies Bayer Technology Services GmbH , Bayer Business Services GmbH and Bayer Industry Services GmbH & Co. OHG. In 2016, the company began a second restructuring with the aim of allowing it to transition to a life sciences based company. By divesting its Chemicals division in 2004 and with the aim of off-loading its Materials division by mid-2016, Bayer will be left with

10560-399: The trademarked name Aspirin . Aspirin is on the World Health Organization's List of Essential Medicines . In 2021, it was the 34th most commonly prescribed medication in the United States, with more than 17   million prescriptions. In 1904, Bayer received a trademark for the "Bayer Cross" logo, which was subsequently stamped onto each aspirin tablet, creating an iconic product that

10670-687: The treatment costs. A national referendum in November 2008 showed 68% of voters supported the plan, introducing diamorphine prescription into federal law. The previous trials were based on time-limited executive ordinances. The success of the Swiss trials led German, Dutch, and Canadian cities to try out their own diamorphine prescription programs. Some Australian cities (such as Sydney) have instituted legal diamorphine supervised injecting centers , in line with other wider harm minimization programs. Since January 2009, Denmark has prescribed diamorphine to

10780-509: The unpleasant side effects of nausea and gastric pain . He also said he had invented the name aspirin and was the first person to use the new formulation to test its safety and efficacy. Bayer contends that aspirin was discovered by Felix Hoffmann to help his father, who had arthritis . Various sources support the conflicting claims. Most mainstream historians attribute the invention of aspirin to Hoffmann and/or Eichengrün. Heroin (diacetylmorphine), now illegal as an addictive drug,

10890-401: The world as heroin are routinely diluted with cutting agents . Black tar heroin is a variable admixture of morphine derivatives—predominantly 6-MAM (6-monoacetylmorphine), which is the result of crude acetylation during clandestine production of street heroin. Heroin is typically injected , usually into a vein , but it can also be snorted, smoked, or inhaled. In a clinical context,

11000-472: The world's largest chemical and pharmaceutical corporations. In 2016, Bayer merged with the American multinational Monsanto in what was the biggest acquisition by a German company to date. However, owing to the massive financial and reputational blows caused by ongoing litigation concerning Monsanto's herbicide Roundup , the deal is considered one of the worst corporate mergers in history. Bayer owns

11110-467: Was acetylsalicylic acid —first described by French chemist Charles Frederic Gerhardt in 1853 —a modification of salicylic acid or salicin , a folk remedy found in the bark of the willow plant. By 1899, Bayer's trademark Aspirin was registered worldwide for Bayer's brand of acetylsalicylic acid, but it lost its trademark status in the United States, France and the United Kingdom after

11220-679: Was at that point known as Farbenfabriken Bayer AG ; it changed its name to Bayer AG in 1972. After the war, some employees of Bayer appeared in the IG Farben Trial, one of the Nuremberg Subsequent Tribunals under US jurisdiction. Among them was Fritz ter Meer , who helped to plan the Monowitz camp (Auschwitz III) and IG Farben's Buna Werke factory at Auschwitz, where medical experimentation had been conducted and where 25,000 forced laborers were deployed. Ter Meer

11330-570: Was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories. Following World War II , the Allied Control Council seized IG Farben's assets because of its role in the Nazi war effort and involvement in the Holocaust , including using slave labour from concentration camps and humans for dangerous medical testing, and production of Zyklon B , a chemical used in gas chambers . In 1951, IG Farben

11440-431: Was discontinued; its products are now marketed under the Bayer name. On 16 September 2019, under the approval of National Company Law Tribunal, Bayer completed the merger of Monsanto India. Bayer's Monsanto acquisition is the biggest acquisition by a German company to date. However, owing to ongoing litigation concerning the Monsanto's herbicide Roundup and the massive financial and reputational blows it has caused Bayer,

11550-455: Was introduced as a non-addictive substitute for morphine , and trademarked and marketed by Bayer from 1898 to 1910 as a cough suppressant and over-the-counter treatment for other common ailments, including pneumonia and tuberculosis . While Bayer scientists were not the first to make heroin, the company did lead the way in commercializing it. Heroin was a Bayer trademark until after World War I. Bayer's director of pharmacology did not want

11660-502: Was listed on the Frankfurt Stock Exchange with the trading symbol SY1. With 81,030,358 shares issued at an issue price of €17.25 for a total volume of €1.4 billion, it was the largest German public offering of 2006. On 19 March 2007, Symrise was added to the German MDAX stock index. In March 2013, Symrise acquired US-owned fragrance manufacturer Belmay Fragrances for an undisclosed sum. On 12 April 2014, Symrise had announced

11770-412: Was sentenced to seven years, but was released in 1950. Despite being a convicted nazi war criminal , Ter Meer was elected as chairman of Bayer AG's supervisory board in 1956, a position he retained until 1964. Helge Wehmeier, then CEO of Bayer, offered a public apology in 1995 to Elie Wiesel for the company's actions during World War II (1939–1945) and the Holocaust . In 1953, Bayer brought

11880-529: Was split into its constituent companies, and Bayer was reincorporated as Farbenfabriken Bayer AG. After the war, Bayer re-hired several former Nazis to high-level positions, including convicted Nazi war criminals found guilty at the IG Farben Trial like Fritz ter Meer . Bayer played a key role in the Wirtschaftswunder in post-war West Germany , quickly regaining its position as one of

11990-720: Was the largest take-over in Bayer's history, and as of 2015, was one of the ten biggest pharma mergers of all time. In November 2010, Bayer AG signed an agreement to buy Auckland-based animal health company Bomac Group. Bayer partnered on the development of the radiotherapeutic Xofigo with Algeta, and in 2014, moved to acquire the company for about $ 2.9 billion. In 2014, Bayer agreed to buy Merck's consumer health business for $ 14.2 billion which would provide Bayer control with brands such as Claritin, Coppertone and Dr. Scholl's. Bayer would attain second place globally in nonprescription drugs. In June 2015, Bayer agreed to sell its diabetic care business to Panasonic Healthcare Holdings for

12100-731: Was withdrawn from the market worldwide in 2007 when reports of increased mortality emerged; it was later re-introduced in Europe but not in the US. In 2014, pharmaceutical products contributed €12.05 billion of Bayer's €40.15 billion in gross revenue. In 2019, identified "key growth" products were Xarelto ( rivaroxaban ), Eylea ( aflibercept ), Stivarga ( regorafenib ), Xofigo ( radium-223 ), and Adempas (riociguat). Top-selling products as of 2014 included: Bayer produces various fungicides, herbicides, insecticides, and some crop varieties. In 1994, Bayer AG purchased Sterling Winthrop's over-the-counter (OTC) drug business from SmithKline Beecham and merged it with Miles Laboratories, thereby reclaiming

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