PAC-1 ( first procaspase activating compound) is a synthesized chemical compound that selectively induces apoptosis , in cancerous cells. It was granted orphan drug status by the FDA in 2016.
130-548: PAC-1 was discovered in Professor Paul Hergenrother's laboratory at the University of Illinois at Urbana–Champaign during a process that screened many chemicals for anti-tumor potential. This molecule, when delivered to cancer cells, signals the cells to self-destruct by activating an "executioner" protein, procaspase-3 . Then, the activated executioner protein begins a cascade of events that destroys
260-768: A public land-grant research university in the Champaign–Urbana metropolitan area , Illinois, United States. It is the flagship institution of the University of Illinois system and was established in 1867. With over 59,000 students, the University of Illinois is one of the largest public universities by enrollment in the United States. The university contains 16 schools and colleges and offers more than 150 undergraduate and over 100 graduate programs of study. The university holds 651 buildings on 6,370 acres (2,578 ha) and its annual operating budget in 2016
390-416: A Digital World, which focuses on how digital tools like internet, smartphone and 3D printers are changing the marketing landscape. In the 2021 U.S. News & World Report "America's Best Colleges" report, UIUC's undergraduate program was ranked tied for 47th among national universities and tied for 15th among public universities, with its undergraduate engineering program ranked tied for 6th in
520-707: A Phase I human clinical trial in cancer patients to begin in early 2015, and indeed the Phase 1 trial of PAC-1 opened for enrollment in February 2015 (NCT02355535). This trial is being conducted at the University of Illinois Cancer Center in Chicago, at the Sidney Kimmel Cancer Center at Johns Hopkins , and at Regions Hospital in St. Paul, MN. A Phase 1b trial of PAC-1 plus temozolomide opened in late 2017 at
650-713: A blog entitled, "On the NSA", in which he contributed to the ongoing debate regarding the role of NIST and NSA in formulating U.S. cryptography standards. On September 9, 2013, Green received a take-down request for the "On the NSA" blog from interim Dean Andrew Douglas from the Johns Hopkins University Whiting School of Engineering . The request cited concerns that the blog had links to sensitive material. The blog linked to already published news articles from The Guardian , The New York Times , and ProPublica.org . Douglas subsequently issued
780-410: A conference center in nearby Monticello at Allerton Park . The campus is known for its landscape and architecture, as well as distinctive landmarks. It was identified as one of 50 college or university "works of art" by T.A. Gaines in his book The Campus as a Work of Art . The campus also has a number of buildings and sites on the U.S. National Register of Historic Places including Harker Hall ,
910-505: A more sustainable future." In 2022, new solar and geothermal energy projects, a reduction in water use, and wide-ranging sustainability research helped the University of Illinois Urbana-Champaign earn its fifth consecutive gold certification in the Sustainability Tracking, Assessment & Rating System (STARS) . Illinois has consistently achieved gold certification since it began reporting data through STARS in 2013, and
1040-534: A new biomedical engineering building in the Johns Hopkins University Department of Biomedical Engineering , a new library, a new biology wing, an extensive renovation of the flagship Gilman Hall, and the reconstruction of the main university entrance. These years also brought about the rapid development of the university's professional schools of education and business. From 1999 until 2007, these disciplines had been joined within
1170-474: A personal on-line apology to Green. The event raised concern over the future of academic freedom of speech within the cryptologic research community. The first campus was located on Howard Street. Eventually, they relocated to Homewood, in northern Baltimore, the estate of Charles Carroll, son of the oldest surviving signer of the Declaration of Independence . Carroll's Homewood House is considered one of
1300-528: A petition calling on president Daniels to reconsider the planned police department. The office of public safety issued a statement on June 10 saying "the JHPD does not yet exist. We committed to establishing this department through a slow, careful and fully open process. No other steps are planned at this time, and we will be in close communication with the city and our university community before any further steps are taken". Two days later, president Daniels announced
1430-533: A rare books collection. The Johns Hopkins University Press is the publishing division of the Johns Hopkins University. It was founded in 1878 and holds the distinction of being the oldest continuously running university press in the United States. To date the Press has published more than 6,000 titles and currently publishes 65 scholarly periodicals and over 200 new books each year. Since 1993,
SECTION 10
#17327759721521560-552: A separate identity for the main campus within the University of Illinois System , which today includes separate institutions at the University of Illinois Chicago (formed by the merger of UICC and UIMC) and University of Illinois Springfield . In 1998, the Hallene Gateway Plaza was dedicated. The Plaza features the original sandstone portal of University Hall, which was originally the fourth building on campus. In recent years, state support has declined from 4.5% of
1690-443: A two-term limit. The alumni select 12 trustees. Four recent alumni serve 4-year terms, one per year, typically from the graduating class. The bylaws prohibit students, faculty or administrative staff from serving on the board, except the president as an ex-officio trustee. The Johns Hopkins Health System has a separate board of trustees, many of whom are doctors or health care executives. The full-time, four-year undergraduate program
1820-418: Is "most selective" with low transfer-in and a high graduate co-existence. The Princeton Review rates the selectivity of Johns Hopkins as 99/99. The cost of attendance per year is approximately $ 77,400. However, 51% of full-time undergraduates receive financial aid covering 100% of their need. The admit rate of Hopkins undergraduates to medical school is 80% and to law school is 97%, some of the highest rates in
1950-704: Is a private research university in Baltimore , Maryland, United States. Founded in 1876, Johns Hopkins was the first American university based on the European research institution model. The university also has graduate campuses in Italy, China, and Washington, D.C. The university was named for its first benefactor, the American entrepreneur and Quaker philanthropist Johns Hopkins . Hopkins's $ 7 million bequest (equivalent to $ 162 million in 2023) to establish
2080-633: Is a collaboration between the Technology Entrepreneur Center and EnterpriseWorks, with participation from the Office of Technology Management and IllinoisVentures. The program consists of three workshops over six weeks, where teams work to validate the market size, value propositions, and customer segments of their innovations. SocialFuse is a recurring pitching and networking event where students can pitch ideas, find teammates, and network. The Center for Plasma-Material Interactions
2210-821: Is a week-long workshop, occurring annually in January. Students visit startups and technology companies in the Silicon Valley and network entrepreneurial alumni from the University of Illinois Urbana-Champaign. Students are exposed to technology entrepreneurship, innovation, and leadership. The trip features corporate leaders, venture capitalists, and entrepreneurs in various stages of a startup lifecycle. Illinois I-Corps teaches National Science Foundation grantees how to learn to identify valuable product opportunities that can emerge from academic research, and gain skills in entrepreneurship through training in customer discovery and guidance from established entrepreneurs. The program
2340-792: Is in Baltimore , Johns Hopkins also maintains ten divisions on campuses in other Maryland locations, including Laurel , Rockville , Columbia , Aberdeen , California , Elkridge , and Owings Mills . The two undergraduate divisions, the Zanvyl Krieger School of Arts and Sciences and the Whiting School of Engineering are located on the Homewood campus in Baltimore's Charles Village neighborhood. The medical school , nursing school , Bloomberg School of Public Health , and Johns Hopkins Children's Center are located on
2470-447: Is known to be inhibited by low levels of zinc. PAC-1 activates procaspase-3 by chelating zinc, thus relieving the zinc-mediated inhibition. This allows procaspase-3 to be an active enzyme, and it can then cleave another molecule of procaspase-3 to active caspase-3. Caspase-3 can further activate other molecules of procaspase-3 in the cell, causing an exponential increase in caspase-3 concentration. PAC-1 facilitates this process and causes
2600-580: Is led through live sessions, headed by UIUC faculty. Similar to the university's on-campus admission policies, the online master's degrees offered by The University of Illinois through Coursera also has admission requirements. All applicants must hold a bachelor's degree, and have earned a 3.0 GPA or higher in the last two years of study. Additionally, all applicants must prove their proficiency in English. The University of Illinois also offers online courses in partnership with Coursera, such as Marketing in
2730-1065: Is located on campus and is the home of the Illinois Natural History Survey , Illinois State Geological Survey, Illinois State Water Survey, Illinois Sustainable Technology Center, and the Illinois State Archeological Survey. Researchers at the Prairie Research Institute are engaged in research in agriculture and forestry, biodiversity and ecosystem health, atmospheric resources, climate and associated natural hazards, cultural resources and history of human settlements, disease and public health, emerging pests, fisheries and wildlife, energy and industrial technology, mineral resources, pollution prevention and mitigation, and water resources. The Illinois Natural History Survey collections include crustaceans, reptiles and amphibians, birds, mammals, algae, fungi, and vascular plants, with
SECTION 20
#17327759721522860-538: Is one of the distinguishing characteristics of Hopkins's undergraduate education. About 80 percent of undergraduates perform independent research, often alongside top researchers. In fiscal year 2020, Johns Hopkins spent nearly $ 3.1 billion on research, more than any other U.S. university for over 40 consecutive years. Johns Hopkins has had seventy-seven members of the Institute of Medicine , forty-three Howard Hughes Medical Institute Investigators, seventeen members of
2990-432: Is the primary campus for master's degrees in a variety of STEM fields. The Johns Hopkins entity is structured as two corporations, the university and The Johns Hopkins Health System, formed in 1986. The president is JHU's chief executive officer and the university is organized into nine academic divisions. JHU's bylaws specify a board of trustees of between 18 and 65 voting members. Trustees serve six-year terms subject to
3120-429: Is uncertain. A potential selectivity problem arises because procaspase-3 is present in most cells of the body. However, it has been shown that in many cancers, including certain neuroblastomas , lymphomas , leukemias , melanomas , and liver cancers , procaspase-3 is present in higher concentrations. For instance, lung cancer cells can have over 1000 times more procaspase-3 than normal cells. Therefore, by controlling
3250-513: The American Physical Society , the classical scholars Basil Gildersleeve , and Charles D. Morris; the economist Richard T. Ely ; and the chemist Ira Remsen , who became the second president of the university in 1901. Gilman focused on the expansion of graduate education and support of faculty research. The new university fused advanced scholarship with such professional schools as medicine and engineering. Hopkins became
3380-766: The Astronomical Observatory , Louise Freer Hall , the Main Library , the Experimental Dairy Farm Historic District , and the Morrow Plots . University of Illinois Willard Airport is one of the few airports owned by an educational institution. In 2008, the University of Illinois Urbana-Champaign became a signatory of the American College and University Presidents' Climate Commitment, binding
3510-690: The COVID-19 pandemic by compiling data from hundreds of sources around the world. This led to the university becoming one of the most cited sources for data about the pandemic. In February 2019, Johns Hopkins University requested permission from the Maryland General Assembly to create a private police force to patrol in and around the three Baltimore campuses, a move that was immediately opposed by several neighboring communities, 75% of Johns Hopkins undergraduate students, and at least 90 professors who signed on to an open letter opposing
3640-676: The Grainger College of Engineering has an admit rate of 22.3%. Certain in-demand majors like Computer Science, including Computer Science + X, of which the program being ranked consistently 5th nationwide can be extremely competitive, with an acceptance rate of less than 6.8% in 2022, and average freshman ACT composite score of 33.7. Computer Science + X admit rate: 18.1% In 2009, an investigation by The Chicago Tribune reported that some applicants "received special consideration " for acceptance between 2005 and 2009, despite having sub-par qualifications. This incident became known as
3770-525: The Humboldtian model of higher education , the German education model of Wilhelm von Humboldt , it became dedicated to research. It was especially Heidelberg University and its long academic research history on which the new institution tried to model itself. Johns Hopkins thereby became the model of the modern research university in the United States. Its success eventually shifted higher education in
3900-717: The John Bardeen Quadrangle occupy the center of the Engineering Campus . Boneyard Creek flows through the John Bardeen Quadrangle, parallel to Green Street. The Beckman Quadrangle, named after Arnold Orville Beckman , is primarily composed of research units and laboratories, and features a large solar calendar consisting of an obelisk and several copper fountains. The Main Quadrangle and South Quadrangle follow immediately after
4030-669: The Max Planck Society in the number of total citations published in Thomson Reuters-indexed journals over 22 fields in America. In 2020, Johns Hopkins University ranked 5 in number of utility patents granted out of all institutions in the world. In 2000, Johns Hopkins received $ 95.4 million in research grants from the National Aeronautics and Space Administration (NASA), making it
PAC-1 - Misplaced Pages Continue
4160-597: The National Academy of Engineering , and sixty-two members of the National Academy of Sciences . As of October 2019, 39 Nobel Prize winners have been affiliated with the university as alumni, faculty members or researchers, with the most recent winners being Gregg Semenza and William G. Kaelin . Between 1999 and 2009, Johns Hopkins was among the most cited institutions in the world. It attracted nearly 1,222,166 citations and produced 54,022 papers under its name, ranking third globally after Harvard University and
4290-518: The Rose Bowl Game in 1947, 1952, 1964 and a total of five national championships. Illinois athletes have won 29 medals in Olympic events . The alumni, faculty members, or researchers of the university include 30 Nobel laureates, 27 Pulitzer Prize winners, two Fields medalists , and two Turing Award winners. The University of Illinois, originally named "Illinois Industrial University",
4420-594: The School of Advanced International Studies in Washington, D.C. , and the Peabody Institute in Baltimore were incorporated into the university. The early decades of the 21st century saw expansion across the university's institutions in both physical and population sizes. Notably, a planned 88-acre expansion to the medical campus began in 2013. Completed construction on the Homewood campus has included
4550-674: The Siebel Center for Design , and $ 50 million to support the renamed Department of Computer Science to become Siebel School of Computing and Data Science. Furthermore, the Grainger Foundation (founded by alumnus W. W. Grainger ) has contributed more than $ 300 million to the university over the last half-century, including donations for the construction of the Grainger Engineering Library . Larry Gies and his wife Beth donated $ 150 million in 2017 to
4680-576: The U.S. Department of Defense , NASA , and other government and civilian research agencies. Among other projects, it has designed, built, and flown spacecraft for NASA to the asteroid Eros, and the planets Mercury and Pluto. It has developed more than 100 biomedical devices, many in collaboration with the Johns Hopkins Medical Institutions. Akin to the Washington, D.C. campus for the School of Arts and Sciences, APL also
4810-585: The Universal Parallel Computing Research Center . The university contracted with Cray to build the National Science Foundation -funded supercomputer Blue Waters . The system also has the largest public online storage system in the world with more than 25 petabytes of usable space. The university celebrated January 12, 1997, as the "birthday" of HAL 9000 , the fictional supercomputer from
4940-574: The University of Illinois clout scandal . The university offers more than 150 undergraduate and 100 graduate and professional programs in over 15 academic units, among several online specializations such as Digital Marketing and an online MBA program launched in January 2016. In 2015, the university announced its expansion to include an engineering-based medical program, which would be the first new college created in Urbana-Champaign in 60 years. The university also offers undergraduate students
5070-709: The fourth-largest university library in the United States by holdings. The university also hosts the National Center for Supercomputing Applications . Illinois athletic teams compete in Division I of the NCAA and are collectively known as the Fighting Illini . They are members of the Big Ten Conference and have won the second-most conference titles . Illinois Fighting Illini football won
5200-405: The liberal arts tradition was at odds with many state residents and lawmakers who wanted the university to offer classes based solely around "industrial education". The university opened for classes on March 2, 1868, and had two faculty members and 77 students. The Library, which opened with the school in 1868, started with 1,039 volumes. Subsequently, President Edmund J. James , in a speech to
5330-518: The 1801 Homewood House , still stands and serves as an on-campus museum. The brick and marble Federal style of Homewood House became the architectural inspiration for much of the university campus versus the Collegiate Gothic style of other historic American universities. In 1909, the university was among the first to start adult continuing education programs and in 1916 it founded the nation's first school of public health . Since
PAC-1 - Misplaced Pages Continue
5460-592: The 1910s, Johns Hopkins University has famously been a "fertile cradle" to Arthur Lovejoy 's history of ideas . Since 1942, the Johns Hopkins Applied Physics Laboratory (APL) has served as a major governmental defense contractor. In tandem with on-campus research, Johns Hopkins has every year since 1979 had the highest federal research funding of any American university. Professional schools of international affairs and music were established in 1950 and 1977, respectively, when
5590-463: The 2011 fiscal year, Research Park produced an economic output of $ 169.5M for the state of Illinois. The Technology Entrepreneur Center at the University of Illinois Urbana-Champaign is a permanent center established to provide students with resources for their entrepreneurial ideas. The center offers classes, venture and product competitions, and workshops to introduce students to technology innovation and market adoption. Events and programs hosted by
5720-635: The 2019 Garland Hall sit-in. The group proceeded to shut down the first town hall. According to reporting by the Baltimore Sun, the event "was moved to an online-only format after a crowd of chanting protesters took over the meeting stage." The MOU finalized on December 2, 2022, grants the JHPD primary jurisdiction over areas "owned, leased, or operated by, or under the control of" JHU as well as adjacent public property. Despite continued protest from university faculty calling for more oversight and clearly defined jurisdictional boundaries in accordance with
5850-408: The 2022 score was one of its highest to date. Currently, the campus features 27 LEED-certified buildings. As of 2024, 87% of students graduate within 8 years of entering, compared to the national median of 58% for all 4-year universities nationwide. The overall first-year admit rate for 2023 is 43.7%, which differ greatly among UIUC colleges — whereas the overall first-choice admit rate is 34.7%,
5980-588: The 30th year in a row, according to a National Science Foundation (NSF) ranking. These totals include grants and expenditures of JHU's Applied Physics Laboratory in Laurel, Maryland. In 2013, the Bloomberg Distinguished Professorships program was established by a $ 250 million gift from Michael Bloomberg . This program enables the university to recruit fifty researchers from around the world to joint appointments throughout
6110-559: The Baltimore Police Department. A draft MOU was made public on September 19, 2022 in advance of three scheduled town halls and a 30-day period to solicit feedback from the community. A message posted the same day as the draft MOU said that the document "will be modified to reflect what we hear and learn from our community." However, community members remained skeptical that the university is operating in good faith. A September 2022 article from Inside Higher Ed portrays
6240-654: The College of Fine and Applied Arts was ranked 3rd nationally by Planetizen in 2015. The university was also listed as a "Public Ivy" in The Public Ivies: America's Flagship Public Universities (2001) by Howard and Matthew Greene. The Princeton Review ranked Illinois 1st in its 2016 list of top party schools. Internationally, UIUC engineering was ranked 13th in the world in 2016 by the Academic Ranking of World Universities (ARWU) and
6370-721: The East Baltimore facility occupies several city blocks spreading from the Johns Hopkins Hospital trademark dome. In 2019, Hopkins announced its purchase of the Newseum building on Pennsylvania Avenue , three blocks from the United States Capitol , to house its Washington, D.C. programs and centers. The Applied Physics Laboratory (APL), in Laurel, Maryland , specializes in research for
6500-668: The Eisenhower library's six stories are above ground, though the building was designed so that every level receives natural light. The design accords with campus lore that no structure can be taller than Gilman Hall, the flagship academic building. A four-story expansion to the library, known as the Brody Learning Commons, opened in August 2012. The expansion features an energy-efficient, state-of-the-art technology infrastructure and includes study spaces, seminar rooms, and
6630-452: The FDA, and in late 2017 a Phase 1b trial began of PAC-1 plus temozolomide for treatment of patients with recurrent glioblastoma or anaplastic astrocytoma. In cells, the executioner protein, caspase-3, is stored in its inactive form, procaspase-3. This way, the cell can quickly undergo apoptosis by activating the protein that is already there. This inactive form is called a zymogen . Procaspase-3
SECTION 50
#17327759721526760-571: The Homewood Faculty Assembly unanimously passed a resolution requesting that the administration refrain from taking any further steps "toward the establishment of a private police force" until it could provide responses to several questions concerning accountability and oversight of the proposed police department, fears of Black faculty that the police department would target people of color, and alleged corruption involving Mayor Pugh. The Community Safety and Strengthening Act passed
6890-509: The Illinois Industrial University officially changed its name to the "University of Illinois", reflecting its agricultural, mechanical, and liberal arts curriculum. According to educational historian Roger L. Geiger , Illinois and a few other public and private universities set the standard for what the research university in the United States would become. During his presidency, Edmund J. James (1904–1920) set
7020-637: The John Bardeen Quad. The former makes up a large part of the Liberal Arts and Sciences portion of the campus, while the latter comprises many of the buildings of the College of Agriculture, Consumer, and Environmental Sciences (ACES) spread across the campus map. Additionally, the research fields of the College of ACES stretch south from Urbana and Champaign into Savoy and Champaign County . The university also maintains formal gardens and
7150-620: The John Work Garrett Library at Evergreen House , and the George Peabody Library at the Peabody Institute campus. The main library, constructed in the 1960s, was named for Milton S. Eisenhower , former president of the university and brother of former U.S. president Dwight D. Eisenhower . The university's stacks had previously been housed in Gilman Hall and departmental libraries. Only two of
7280-408: The Johns Hopkins University Press has run Project MUSE , an online collection of over 250 full-text, peer-reviewed journals in the humanities and social sciences. The Press also houses the Hopkins Fulfilment Services (HFS), which handles distribution for a number of university presses and publishers. Taken together, the three divisions of the Press—Books, Journals (including MUSE) and HFS—make it one of
7410-439: The Maryland General Assembly and was signed into law in April 2019, granting Johns Hopkins University permission to establish a private police department. In response to perceived corruption, a group of protestors staged a sit-in of Garland Hall, the building housing the office of university president Ronald J. Daniels . After a month-long sit-in, the protestors "took over the building – locking its doors with chains." They held
7540-479: The Medical Institutions campus in East Baltimore. The university also consists of the Peabody Institute , Applied Physics Laboratory , School of Advanced International Studies , School of Education , Carey Business School , and various other facilities . Founded in 1883, the Blue Jays men's lacrosse team has captured 44 national titles and plays in the Big Ten Conference as an affiliate member. The university's other sports teams compete in Division III of
7670-405: The NCAA as members of the Centennial Conference . On his death in 1873, Johns Hopkins , a Quaker entrepreneur and childless bachelor, bequeathed $ 7 million (equivalent to $ 162 million in 2023) to fund a hospital and university in Baltimore . At the time, this donation, generated primarily from the Baltimore and Ohio Railroad , was the largest philanthropic gift in the history of
7800-478: The Office of Admissions accepted about 4.9% of its 33,236 Regular Decision applicants and about 6.4% of its total 38,725 applicants. In 2022, 99% of admitted students graduated in the top 10% of their high school class. Over time, applications to Johns Hopkins University have risen steadily; as a result, the selectivity of Johns Hopkins University has also increased. Early Decision I is an option at Johns Hopkins University for students who wish to demonstrate that
7930-439: The School of Professional Studies in Business and Education (SPSBE), itself a reshuffling of several earlier ventures. The 2007 split, combined with new funding and leadership initiatives, has led to the simultaneous emergence of the Johns Hopkins School of Education and the Carey Business School . On November 18, 2018, it was announced that Michael Bloomberg would make a donation to his alma mater of $ 1.8 billion, marking
SECTION 60
#17327759721528060-425: The TEC include the Cozad New Venture Challenge, Silicon Valley Entrepreneurship Workshop, Illinois I-Corps, and SocialFuse. The campus-wide Cozad New Venture Challenge has been held annually since 2000. Participants are mentored in the phases of venture creation and attend workshops on idea validation, pitching skills, and customer development. In 2019, teams competed for $ 250,000 in funding. The Silicon Valley Workshop
8190-418: The Top 25 American Research Universities by The Center for Measuring University Performance . Beside annual influx of grants and sponsored projects, the university manages an extensive modern research infrastructure. The university has been a leader in computer based education and hosted the PLATO project, which was a precursor to the internet and resulted in the development of the plasma display . Illinois
8320-413: The Toughest Problems in Computer Science," he mentioned Microsoft hires more graduates from the University of Illinois Urbana-Champaign than from any other university in the world. Alumnus William M. Holt, a senior vice-president of Intel , also mentioned in a campus talk on September 27, 2007, entitled "R&D to Deliver Practical Results: Extending Moore's Law" that Intel hires more PhD graduates from
8450-486: The U.S. among schools whose highest degree is a doctorate. Washington Monthly ranked UIUC 18th among 389 national universities in the U.S. for 2020, based on its contribution to the public good as measured by social mobility, research, and promoting public service. Kiplinger's Personal Finance rated Illinois 12th in its 2019 list of 174 Best Values in Public Colleges, which "measures academic quality, cost and financial aid." The Graduate Program in Urban Planning at
8580-473: The US. The university is one of fourteen founding members of the Association of American Universities (AAU); it is also a member of the Consortium on Financing Higher Education (COFHE) and the Universities Research Association (URA). As of 2024–25, Johns Hopkins University is ranked the 6th best university in the nation (tied) and 13th best globally by U.S. News & World Report . The university's undergraduate programs are highly selective: in 2021,
8710-413: The United States from a focus on teaching revealed and/or applied knowledge to the scientific discovery of new knowledge. The trustees worked alongside four notable university presidents, Charles W. Eliot of Harvard University , Andrew D. White of Cornell University , Noah Porter of Yale College , and James B. Angell of University of Michigan . They each supported Daniel Coit Gilman to lead
8840-588: The United States, and endowment was then the largest in America. Until 2020, Hopkins was assumed to be a fervent abolitionist , until research done by the school into his United States Census records revealed he claimed to own at least five household slaves in the 1840 and 1850 decennial censuses. The first name of philanthropist Johns Hopkins comes from the surname of his great-grandmother, Margaret Johns, who married Gerard Hopkins. They named their son Johns Hopkins, who named his own son Samuel Hopkins. Samuel named one of his sons for his father, and that son became
8970-664: The University of Illinois Urbana-Champaign than from any other university in the country. In 2007, the university-hosted research Institute for Condensed Matter Theory (ICMT) was launched, with the director Paul Goldbart and the chief scientist Anthony Leggett . ICMT is currently located at the Engineering Science Building on campus. The University Professional and Continuing Education Association (UPCEA), which recognizes excellence in both individual and institutional achievements, has awarded two awards to U of I. Johns Hopkins University The Johns Hopkins University (often abbreviated as Johns Hopkins , Hopkins , or JHU )
9100-422: The board of trustees in 1912, proposed to create a research library. It is now one of the world's largest public academic collections. In 1870, the Mumford House was constructed as a model farmhouse for the school's experimental farm. The Mumford House remains the oldest structure on campus. The original University Hall (1871) was the fourth building built; it stood where the Illini Union stands today. In 1885,
9230-452: The building for a week until May 8, 2019, when "[a]t 5:50 a.m., at the request of Johns Hopkins University," Baltimore police surrounded the building and arrested "three community members, one undergraduate and one graduate student" who were occupying the building. In the wake of the May 2020 killing of George Floyd and the subsequent protests , a group of Hopkins faculty along with 2,500 Hopkins staff, students, and community members signed
9360-411: The campus to the goal of carbon neutrality as soon as possible. In 2010, the first Illinois Climate Action Plan (iCAP) was written to chart a path to this goal. The iCAP is a strategic framework for meeting the university's Climate Leadership Commitments to be carbon-neutral by 2050 or sooner and build resilience with its local community. Since then, the iCAP has been rewritten every five years to track
9490-626: The ceding of lands by the university for the public Wyman Park and Wyman Park Dell and the Baltimore Museum of Art , coalescing in the contemporary area of 140 acres (57 ha). Prior to becoming the main Johns Hopkins campus, the Homewood estate had initially been the gift of Charles Carroll of Carrollton, Maryland , a planter and signer of the Declaration of Independence , to his son Charles Carroll Jr. The original structure,
9620-566: The cell to undergo apoptosis quickly. This direct procaspase-3 activation mode-of-action for PAC-1 has been confirmed by other laboratories: In 2013 by the Megeney lab during the course of studies on the role of caspase-3 in cardiomyocytes, in 2014 by the Wu lab in an extensive study on the anticancer activity and mode-of-action of PAC-1 and derivatives, and in 2015 by the Gandhi lab in an exploration of
9750-574: The city as public park. A solution was achieved by a team of prominent locals who acquired the estate in north Baltimore known as the Homewood Campus of Johns Hopkins University . On February 22, 1902, this land was formally transferred to the university. The flagship building, Gilman Hall, was completed in 1915. The School of Engineering relocated in Fall of 1914 and the Zanvyl Krieger School of Arts and Sciences followed in 1916. These decades saw
9880-432: The decision to "pause for at least the next two years the implementation of the JHPD." Despite this announcement, the next summer Johns Hopkins announced the appointment of Dr. Branville Bard Jr. to the newly created position of vice president for public safety. The Community Safety and Strengthening Act requires the university to establish a civilian accountability board as well as a Memorandum Of Understanding (MOU) with
10010-561: The dosage, one can achieve selectivity between normal and cancerous cells. In addition to its stand-alone activity, PAC-1 has also been shown to markedly synergize with a variety of approved cancer drugs, for example with BRAF and MEK inhibitors in mouse models of melanoma, and with conventional chemotherapeutic agents such as doxorubicin in pet dogs with spontaneous cancers including lymphoma and metastatic osteosarcoma , and with temozolomide in pet dogs with naturally occurring glioma . Vanquish Oncology reported their intention to begin
10140-412: The emerging field of academic medicine, including William Osler , William Halsted , Howard Kelly , and William Welch . During this period the university further made history by becoming the first medical school to admit women on an equal basis with men and to require a Bachelor's degree , based on the efforts of Mary E. Garrett , who had endowed the school at Gilman's request. The school of medicine
10270-596: The finest examples of Federal residential architecture. The estate then came to the Wyman family, which participated in making it the park-like main campus of the schools of arts and sciences and engineering at the start of the 20th century. Most of its architecture was modeled after the Federal style of Homewood House . Homewood House is preserved as a museum. Most undergraduate programs are on this campus. Collectively known as Johns Hopkins Medical Institutions (JHMI) campus,
10400-422: The first successful blue baby operation in 1944. Despite such cases, racial diversity did not become commonplace at Johns Hopkins institutions until the 1960s and 1970s. Hopkins's most well-known battle for women's rights was the one led by daughters of trustees of the university; Mary E. Garrett , M. Carey Thomas , Mamie Gwinn, Elizabeth King, and Julia Rogers. They donated and raised the funds needed to open
10530-629: The full financial need of all admitted students. The Johns Hopkins University Library system houses more than 3.6 million volumes and includes ten main divisions across the university's campuses. The largest segment of this system is the Sheridan Libraries, encompassing the Milton S. Eisenhower Library (the main library of the Homewood campus ), the Brody Learning Commons, the Hutzler Reading Room ("The Hut") in Gilman Hall,
10660-449: The heart of Washington, D.C. , with plans to locate all of its Washington, D.C.-based graduate programs there. In an interview with The Atlantic , the president of Johns Hopkins stated that, "the purchase is an opportunity to position the university, literally, to better contribute its expertise to national- and international-policy discussions." In late 2019, the university's Coronavirus Research Center began tracking worldwide cases of
10790-408: The human clinical trial. In 2010, a study showed PAC-1 to be safe for dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small phase I clinical trial of dogs with lymphoma. More recently, in addition to this single-agent activity PAC-1 has shown to potently synergize with approved cancer drugs, for example with doxorubicin in
10920-406: The iCAP process — especially in the areas of zero waste and conservation of energy, food, water, land, and natural resources — as well as sustainability outreach and immersive educational programs. In her remarks on being named Director of iSEE in 2022, Professor of Agricultural and Consumer Economics Madhu Khanna explained: "We aim to position campus to play a transformative role in moving us all to
11050-414: The idea that the two were mutually exclusive: "The best teachers are usually those who are free, competent and willing to make original researches in the library and the laboratory," he stated. To implement his plan, Gilman recruited internationally known researchers including the mathematician James Joseph Sylvester ; the biologist H. Newell Martin ; the physicist Henry A. Rowland , the first president of
11180-601: The insect collection is among the largest in North America. The Illinois State Geological Survey houses the legislatively mandated Illinois Geological Samples Library, a repository for drill-hole samples in Illinois, as well as paleontological collections. ISAS serves as a repository for a large collection of Illinois archaeological artifacts. One of the major collections is from the Cahokia Mounds. Located in
11310-530: The interest, became virtually worthless soon after Hopkins's death. The university's first home was thus in Downtown Baltimore, delaying plans to site the university in Clifton. In the early 20th century, the university outgrew its buildings and the trustees began to search for a new home. Developing Clifton for the university was too costly, and 30 acres (12 ha) of the estate had to be sold to
11440-495: The largest of America's university presses. The Johns Hopkins University also offers the Center for Talented Youth program, a nonprofit organization dedicated to identifying and developing the talents of the most promising K-12 grade students worldwide. As part of the Johns Hopkins University, the "Center for Talented Youth" or CTY helps fulfill the university's mission of preparing students to make significant future contributions to
11570-452: The largest private donation in modern history to an institution of higher education and bringing Bloomberg's total contribution to the school in excess of $ 3.3 billion. Bloomberg's $ 1.8 billion gift allows the school to practice need-blind admission and meet the full financial need of admitted students. In January 2019, the university announced an agreement to purchase the Newseum , located at 555 Pennsylvania Ave. NW, in
11700-486: The last twenty years state funding for the university has fallen. Private philanthropy increasingly supplements revenue from tuition and state funding, providing about 19% of the annual budget in 2012. Notable among significant donors, alumnus entrepreneur Thomas M. Siebel has committed nearly $ 150 million to the university, including $ 36 million to build the Thomas M. Siebel Center for Computer Science , $ 25 million to build
11830-682: The launch of the Master of Computer Science in Data Science from the University of Illinois Urbana-Champaign. At the time, the university's computer-science graduate program was ranked fifth in the United States by U.S. News & World Report . On March 29, 2017, the University of Illinois Urbana-Champaign launched their Master's in Accounting (iMSA) program, now called the Master of Science in Accountancy (iMSA) program. The iMSA program
11960-516: The law, officer recruitment and training began in spring of 2024, with officers starting active duty in the summer of 2024. Hopkins was a prominent abolitionist who supported Abraham Lincoln during the American Civil War . After his death, reports said his conviction was a decisive factor in enrolling Hopkins's first African-American student, Kelly Miller , a graduate student in physics, astronomy and mathematics. As time passed,
12090-465: The leading recipient of NASA research and development funding. In FY 2002, Hopkins became the first university to cross the $ 1 billion threshold on either list, recording $ 1.14 billion in total research and $ 1.023 billion in federally sponsored research. In FY 2008, Johns Hopkins University performed $ 1.68 billion in science, medical and engineering research, making it the leading U.S. academic institution in total R&D spending for
12220-406: The machinery of the cell. In 2011, Vanquish Oncology Inc. was founded to move PAC-1 forward to a human clinical trial. In 2013, Vanquish announced a multimillion-dollar angel investment into the company. In 2015, a phase I clinical trial of PAC-1 opened for enrollment of cancer patients, and in 2016, it was announced that PAC-1 had been granted Orphan Drug Designation for treatment of glioblastoma by
12350-440: The medical school, and required Hopkins's officials to agree to their stipulation that women would be admitted. The nursing school opened in 1889 and accepted women and men as students. Other graduate schools were later opened to women by president Ira Remsen in 1907. Christine Ladd-Franklin was the first woman to earn a PhD at Hopkins, in mathematics in 1882. The trustees denied her the degree for decades and refused to change
12480-467: The national trendsetter in doctoral programs and the host for numerous scholarly journals and associations. The Johns Hopkins University Press , founded in 1878, is the oldest American university press in continuous operation. With the completion of Johns Hopkins Hospital in 1889 and the medical school in 1893, the university's research-focused mode of instruction soon began attracting world-renowned faculty members who would become major figures in
12610-470: The new university and he became the university's first president. Gilman, a Yale -educated scholar, had been serving as president of the University of California, Berkeley prior to this appointment. In preparation for the university's founding, Gilman visited University of Freiburg and other German universities. Gilman launched what many at the time considered an audacious and unprecedented academic experiment to merge teaching and research. He dismissed
12740-545: The nine divisions and research centers. Each professor must be a leader in interdisciplinary research and be active in undergraduate education . Directed by Vice Provost for Research Denis Wirtz , there are currently thirty two Bloomberg Distinguished Professors at the university, including three Nobel Laureates , eight fellows of the American Association for the Advancement of Science , ten members of
12870-500: The novel and film 2001: A Space Odyssey ; in both works, HAL credits "Urbana, Illinois" as his place of operational origin. The Beckman Institute for Advanced Science and Technology supports interdisciplinary collaborative research in the broad areas of intelligent systems, neuroscience, molecular science and engineering, and biomedical imaging. The Carl R. Woese Institute for Genomic Biology supports research in genomics and related areas of biology. The Prairie Research Institute
13000-471: The opportunity for graduation honors. University Honors is an academic distinction awarded to the highest achieving students. To earn the distinction, students must have a cumulative grade point average of a 3.5/4.0 within the academic year of their graduation and rank within the top 3% of their graduating class. Their names are inscribed on a Bronze Tablet that hangs in the Main Library. In addition to
13130-419: The plan. In early March, it was revealed that "on January 9, 2019, nine senior administrators and one retired hospital CEO...contributed a total of $ 16,000" to then Baltimore Mayor Catherine Pugh 's re-election campaign, shortly after which a bill to institute a Johns Hopkins private police force was introduced into the Maryland General Assembly at "request [of] Baltimore City Administration." On April 8, 2019,
13260-535: The policy about admitting women. In 1893, Florence Bascomb became the university's first female PhD. The decision to admit women at undergraduate level was not considered until the late 1960s and was eventually adopted in October 1969. As of 2009–2010, the undergraduate population was 47% female and 53% male. In 2020, the undergraduate population of Hopkins was 53% female. On September 5, 2013, cryptographer and Johns Hopkins university professor Matthew Green posted
13390-566: The policy of building a massive research library. He also laid the foundation for the large Chinese international student population on campus. James established ties with China through the Chinese Minister to the United States Wu Ting-Fang . Class rivalries and Bob Zuppke's winning football teams contributed to campus morale. Alma Mater , a prominent statue on campus created by alumnus Lorado Taft ,
13520-489: The potential of PAC-1 and derivative B-PAC-1 for treatment of chronic lymphocytic leukemia (CLL). Studies with knockout cells have suggested the importance of procaspase-7 as a secondary or alternate target for PAC-1, especially in the absence of procaspase-3. For example, experiments using mouse embryonic fibroblasts (MEFs) demonstrate that the double knockout of the CASP3 and CASP7 genes leads to cells that are insensitive to
13650-501: The presidency, he decided that it would be best to use the university's endowment for recruiting faculty and students, deciding to, as it has been paraphrased, "build men, not buildings." In his will Hopkins stipulated that none of his endowment should be used for construction; only interest on the principal could be used for this purpose. Unfortunately, stocks in The Baltimore and Ohio Railroad , which would have generated most of
13780-492: The proapoptotic effects of the PAC-1 class of compounds, and knocking in either CASP3 or CASP7 once again sensitizes these cells to PAC-1-type compounds. Recent experiments using cancer cell lines with CRISPR deletion of CASP3 are also consistent with this result. The activation of procaspase-7 by PAC-1 is consistent with biochemical data, although the relative importance of the procaspase-7 target in cells with functional procaspase-3
13910-490: The reverse to refer to the main campus specifically. The university name officially changed to the University of Illinois at Urbana-Champaign by 1977 (although the word "at" was later dropped for marketing purposes by all U of I System campuses by 2021). While this was a reversal of the commonly used designation for the metropolitan area ( Champaign-Urbana ), a majority of the campus is located in Urbana. The name change established
14040-401: The same three sites (NCT03332355); patients with high grade glioma (glioblastoma multiforme (GBM) or anaplastic astrocytoma) after progression following standard first line therapy are eligible for this trial. PAC-1 is notable for the unique path it has taken to the clinic, as it is possibly the only cancer drug to first be rigorously evaluated in pet dogs with spontaneous cancer as a prelude to
14170-501: The sentiment from the community, quoting a Johns Hopkins physician and professor who said "Hopkins engineers very closed and stage-managed town halls and does not execute any changes based on these town halls." The Baltimore Sun reported that the Coalition Against Policing by Hopkins planned to continue to obstruct the formation of JHPD, but that it must resort to "shutting down more university events," referring to
14300-465: The shortly thereafter renamed Gies College of Business . The main research and academic facilities are divided almost evenly between the twin cities of Urbana and Champaign , which form part of the Champaign–Urbana metropolitan area . Some parts are in Urbana Township . Four main quads compose the center of the university and are arranged from north to south. The Beckman Quadrangle and
14430-499: The southwest part of campus, Research Park opened its first building in 2001 and has grown to encompass 13 buildings. Ninety companies have established roots in research park, employing over 1,400 people. Tenants of the Research Park facilities include prominent Fortune 500 companies Capital One, John Deere, State Farm, Caterpillar, and Yahoo, Inc. Companies also employ about 400 total student interns at any given time throughout
14560-502: The state's tax appropriations in 1980 to 2.28% in 2011, a nearly 50% decline. As a result, the university's budget has shifted away from relying on state support with nearly 84% of the budget coming from other sources in 2012. On March 12, 2015, the Board of Trustees approved the creation of a medical school, the first college created at Urbana-Champaign in 60 years. The Carle Illinois College of Medicine began classes in 2018. Over
14690-399: The treatment of pet dogs with lymphoma and metastatic osteosarcoma, and with temozolomide in treating pet dogs with spontaneous glioma. PAC-1 has been or is currently being tested in the following human clinical trials: University of Illinois at Urbana%E2%80%93Champaign The University of Illinois Urbana-Champaign ( UIUC , U of I , Illinois , or University of Illinois ) is
14820-588: The university 38th in 2019; the university was also ranked 48th globally by the Times Higher Education World University Rankings in 2020 and 75th in the world by the QS World University Rankings for 2020. The Center for World University Rankings (CWUR) has ranked University of Illinois Urbana-Champaign as the 20th best university in the world for 2019–20. UIUC is also ranked 32nd in
14950-404: The university adopted a "separate but equal" stance more like other Baltimore institutions. The first black undergraduate entered the school in 1945 and graduate students followed in 1967. James Nabwangu, a British-trained Kenyan, was the first black graduate of the medical school. African-American instructor and laboratory supervisor Vivien Thomas was instrumental in developing and conducting
15080-559: The university is their first choice. These students, if admitted, are required to enroll. This application is due November 1. There is also another binding Early Decision II application due January 3. Many students, however, apply Regular Decision, which is a traditional non-binding round. These applications are due January 3 and students are notified in mid-March. The cost to apply to Hopkins is $ 70, though fee waivers are available. In 2014, Johns Hopkins ended legacy preference in admissions. Johns Hopkins practices need-blind admission and meets
15210-586: The university was the largest philanthropic gift in U.S. history up to that time. Daniel Coit Gilman , who was inaugurated as Johns Hopkins's first president on February 22, 1876, led the university to revolutionize higher education in the U.S. by integrating teaching and research. In 1900, Johns Hopkins became a founding member of the American Association of Universities . The university has led all U.S. universities in annual research and development expenditures for over four consecutive decades ($ 3.18 billion as of fiscal year 2021). While its primary campus
15340-434: The university's Illinois Online platform, in 2015 the university entered into a partnership with the Silicon Valley educational technology company Coursera to offer a series of master's degrees, certifications, and specialization courses, currently including more than 70 joint learning classes. In August 2015, the Master of Business Administration program was launched through the platform. On March 31, 2016, Coursera announced
15470-562: The university's benefactor. Milton Eisenhower , a former university president, once spoke at a convention in Pittsburgh where the master of ceremonies introduced him as "President of John Hopkins". Eisenhower retorted that he was "glad to be here in Pitt burgh". The original board opted for an entirely novel university model dedicated to the discovery of knowledge at an advanced level, extending that of contemporary Germany. Building on
15600-537: The university's progress. In December 2013, the University of Illinois launched the Institute for Sustainability, Energy, and Environment (iSEE) on the Urbana-Champaign campus. The institute, under the Vice Chancellor for Research and Innovation, leads an interdisciplinary approach to researching solutions for the world's most pressing sustainability, energy, and environmental needs. In addition, iSEE has engaged students, faculty, staff, and campus leadership in
15730-511: The world in Times Higher Education World Reputation Rankings for 2018. The University of Illinois Urbana-Champaign is often regarded as a world-leading magnet for engineering and sciences (both applied and basic). According to the National Science Foundation , the university spent $ 625 million on research and development in 2018, ranking it 37th in the nation. It is also listed as one of
15860-803: The world. The Johns Hopkins Digital Media Center (DMC) is a multimedia lab space as well as an equipment, technology and knowledge resource for students interested in exploring creative uses of emerging media and use of technology. Johns Hopkins offers a number of degrees in various undergraduate majors leading to the BA and BS and various majors leading to the MA, MS and PhD for graduate students. Because Hopkins offers both undergraduate and graduate areas of study, many disciplines have multiple degrees available. Biomedical engineering , perhaps one of Hopkins's best-known programs, offers bachelor's, master's, and doctoral degrees. The opportunity to participate in important research
15990-434: The year. The complex is also a center for entrepreneurs, and has over 50 startup companies stationed at its EnterpriseWorks Incubator facility. In 2011, Urbana, Illinois was named number 11 on Popular Mechanics' "14 Best Startup Cities in America" list, in a large part due to the contributions of Research Park's programs. The park has gained recognition from other notable publications, such as inc.com and Forbes magazine. For
16120-404: Was America's first coeducational, graduate-level medical school, and became a prototype for academic medicine that emphasized bedside learning, research projects, and laboratory training. In his will and in his instructions to the trustees of the university and the hospital, Hopkins requested that both institutions be built upon the vast grounds of his Baltimore estate, Clifton. When Gilman assumed
16250-514: Was a 2nd-generation ARPAnet site in 1971 and was the first institution to license the UNIX operating system from Bell Labs. The university hosts the National Center for Supercomputing Applications (NCSA), which created Mosaic , the first graphical web browser , the Apache HTTP server , and NCSA Telnet . The Parallel@Illinois program hosts several programs in parallel computing , including
16380-634: Was also marked by large growth in the Graduate College and increased federal support of scientific and technological research. During the 1950s and 1960s the university experienced the turmoil common on many American campuses. Among these were the water fights of the 1950s and 1960s. By 1967, the University of Illinois system consisted of a main campus in Champaign-Urbana and two Chicago campuses, Chicago Circle (UICC) and Medical Center (UIMC), and people began using "Urbana-Champaign" or
16510-413: Was established in 2004 by Professor David N. Ruzic to research the complex behavior between ions , electrons , and energetic atoms generated in plasmas and the surfaces of materials. CPMI encompasses fusion plasmas in its research. In Bill Gates ' February 24, 2004, talk as part of his Five Campus Tour (Harvard, MIT, Cornell, Carnegie-Mellon and Illinois) titled "Software Breakthroughs: Solving
16640-401: Was one of the 37 universities created under the first Morrill Land-Grant Act , which provided public land for the creation of agricultural and industrial colleges and universities across the United States. Among several cities, Urbana was selected in 1867 as the site for the new school. From the beginning, President John Milton Gregory 's desire to establish an institution firmly grounded in
16770-554: Was over $ 2 billion. The University of Illinois Urbana-Champaign also operates a Research Park home to innovation centers for over 90 start-up companies and multinational corporations . The University of Illinois Urbana-Champaign is a member of the Association of American Universities and is classified among "R1: Doctoral Universities – Very high research activity". In fiscal year 2019, research expenditures at Illinois totaled $ 652 million. The campus library system possesses
16900-553: Was unveiled on June 11, 1929. It was funded from donations by the Alumni Fund and the classes of 1923–1929. The Great Depression in the United States slowed construction and expansion on the campus. The university replaced the original university hall with Gregory Hall and the Illini Union . After World War II, the university experienced rapid growth. The enrollment doubled and the academic standing improved. This period
#151848