4OMC , 4OMD , 4RYD , 4Z2A
14-583: PC1 may refer to: Furin , an enzyme Proprotein convertase 1 , an enzyme Polycystin 1 , a protein in humans associated with autosomal dominant polycystic kidney disease PC-1 , a submarine telecommunications cable system (Pacific Crossing 1) PC1 cipher , used by the Amazon Kindle and some boot loaders First principal component in principal component analysis , often used in genetic distance visualizations [REDACTED] Topics referred to by
28-473: Is a protease , a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene . Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins. It was named furin because it was in the upstream region of an oncogene known as FES . The gene
42-453: Is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: pro parathyroid hormone , transforming growth factor beta 1 precursor, pro albumin , pro- beta-secretase , membrane type-1 matrix metalloproteinase , beta subunit of pro- nerve growth factor and von Willebrand factor . A furin-like pro-protein convertase has been implicated in
56-534: Is also thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for the FURIN gene. Furin is enriched in the Golgi apparatus , where it functions to cleave other proteins into their mature/active forms. Furin cleaves proteins just downstream of a basic amino acid target sequence (canonically, Arg-X-(Arg/Lys) -Arg'). In addition to processing cellular precursor proteins, furin
70-407: Is also used by a number of pathogens. For example, the envelope proteins of viruses such as HIV , influenza , dengue fever , several filoviruses including ebola and marburg virus , and the spike protein of SARS-CoV-2 , must be cleaved by furin or furin-like proteases to become fully functional. When SARS-CoV-2 virus is being synthesized in an infected cell, furin or furin-like proteases cleave
84-555: Is an enzyme that in humans is encoded by the FES gene . FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals. This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity
98-414: Is different from Wikidata All article disambiguation pages All disambiguation pages Furin 5045 18550 ENSG00000140564 ENSMUSG00000030530 P09958 P23188 NM_002569 NM_001289823 NM_001289824 NM_001081454 NM_011046 NP_001369550 NP_001369551 NP_001276752.1 NP_001276753.1 NP_002560.1 NP_001074923 NP_035176 Furin
112-823: Is high, furin traffics to GM1 lipid rafts . When cholesterol is low, furin traffics to the disordered region. This is speculated to contribute to cholesterol and age dependent priming of SARS-CoV. Expression of furin in T-cells is required for maintenance of peripheral immune tolerance . Furin has been shown to interact with PACS1 . Feline sarcoma oncogene 1WQU , 2DCR , 3BKB , 3CBL , 3CD3 , 4DYL , 4E93 2242 14159 ENSG00000182511 ENSMUSG00000053158 P07332 P16879 NM_001143783 NM_001143784 NM_001143785 NM_002005 NM_010194 NP_001137255 NP_001137256 NP_001137257 NP_001996 NP_034324 Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps
126-552: Is required for maintenance of cellular transformation . Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis . A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified. Feline sarcoma oncogene has been shown to interact with BCAR1 and BCR gene . This article on
140-399: The spike protein into two portions (S1 and S2), which remain associated. Anthrax toxin , Pseudomonas exotoxin, and papillomaviruses must be processed by furin during their initial entry into host cells. Inhibitors of furin are under consideration as therapeutic agents for treating anthrax infection. Furin is regulated by cholesterol and substrate presentation . When cholesterol
154-460: The processing of RGMc (also called hemojuvelin ), a gene involved in a severe iron-overload disorder called juvenile hemochromatosis. Both the Ganz and Rotwein groups demonstrated that furin-like proprotein convertases (PPC) are responsible for conversion of 50 kDa HJV to a 40 kDa protein with a truncated COOH-terminus, at a conserved polybasic RNRR site. This suggests a potential mechanism to generate
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#1732802441839168-447: The same term This disambiguation page lists articles associated with the same title formed as a letter–number combination. If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=PC1&oldid=949166452 " Category : Letter–number combination disambiguation pages Hidden categories: Short description
182-429: The soluble forms of HJV/hemojuvelin (s-hemojuvelin) found in the blood of rodents and humans. The furin substrates and the locations of furin cleavage sites in protein sequences can be predicted by two bioinformatics methods: ProP and PiTou. Furin is one of the proteases responsible for the proteolytic cleavage of HIV envelope polyprotein precursor gp160 to gp120 and gp41 prior to viral assembly. This protease
196-504: Was known as FUR (FES Upstream Region) and therefore the protein was named furin. Furin is also known as PACE ( P aired basic A mino acid C leaving E nzyme). A member of family S8 , furin is a subtilisin -like peptidase. The protein encoded by this gene is an enzyme that belongs to the subtilisin -like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein
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