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106-752: The Northern Paiute people are a Numic people that has traditionally lived in the Great Basin region of the United States in what is now eastern California , western Nevada , and southeast Oregon . The Northern Paiute pre-contact lifestyle was well adapted to the harsh desert environment in which they lived. Each tribe or band occupied a specific territory, generally centered on a lake or wetland that supplied fish and waterfowl. Communal hunt drives, which often involved neighboring bands, would take rabbits and pronghorn from surrounding areas. Individuals and families appear to have moved freely among

212-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether

318-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but

424-415: A discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on the distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach

530-570: A distinct linguistic variety, there are no unique linguistic changes that mark Mono as a distinct linguistic variety. The sound system of Numic is set forth in the following tables. Proto-Numic had an inventory of five vowels. Proto-Numic had the following consonant inventory: In addition to the above simple consonants, Proto-Numic also had nasal-stop/affricate clusters and all consonants except *s , *h , *j , and *w could be geminated. Between vowels short consonants were lenited. The major difference between Proto-Central Numic and Proto-Numic

636-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox

742-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major

848-475: A figure in the eyes of the public by making claims of being a princess and using this attention to advocate for her people. Shamanism is popular among most Native American tribes, including the Northern Paiute people. A shaman is a medicine man called a puhagim by Northern Paiute people. The Northern Paiute believe in a force called puha that gives life to the physical world. It is the power that moves

954-479: A fire and cared for it until the fire grew bigger and bigger. The water from the flood dried, and a man "happened." This man was called Nűműzóho, who was a cannibal. The Cannibals (as he and his kind were called) killed all the Native people, except for a woman who was able to escape. This woman kept herself alive by traveling from place to place in the region, meeting and staying with different characters. She then found

1060-593: A fire. The season for story-telling in the American West was during the winter months. The elderly members of the tribe would animatedly and humorously tell the tale from their memory as told to them by previous elders and family members. They were told “as a way to pass on tribal visions of the animal people and the human people, their origins and values, their spiritual and natural environment, and their culture and daily lives.” The stories were often poems that were performed musically, called "song-poems." Members of

1166-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in

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1272-454: A man living in the mountains whom she married. They bore four children: two Paiute (one brother, one sister) and two Pit Rivers (one brother, one sister). The two sets of children fought frequently because they were from different tribes. Their father (some think he was a Wolf) threw them in different waters. This caused them to go their separate ways while continuing to fight and quarrel whenever they came in contact with each other again. And thus

1378-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on

1484-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with

1590-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into

1696-602: A year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of the 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated,

1802-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox

1908-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond

2014-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during

2120-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through

2226-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade

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2332-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope

2438-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c.  1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in

2544-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had

2650-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in

2756-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this

2862-698: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where

2968-661: The Indian Reorganization Act of 1934, several individual colonies gained federal recognition as independent tribes . Humans have inhabited the area between the West and Northwest of the United States for over 11,000 years. One version of how the Northern Paiute people came to be is that a bird, the Sagehen (also known as the Centrocercus ), was the only bird that survived a massive flood. The Sagehen made

3074-597: The New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred

3180-577: The Pyramid Lake War of 1860, Owens Valley Indian War 1861–1864, Snake War 1864–1868; and the Bannock War of 1878. These incidents generally began with a disagreement between settlers and the Paiute (singly or in a group) regarding property, retaliation by one group against the other, and finally counter-retaliation by the opposite party, frequently culminating in the armed involvement of

3286-454: The Reno area, Washoe people. Later, the government created larger reservations at Pyramid Lake and Duck Valley , Nevada . By that time the pattern of small de facto reservations near cities or farm districts, often with mixed Northern Paiute and Shoshone populations, had been established. Starting in the early 20th century, the federal government began granting land to these colonies. Under

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3392-631: The U.S. Army . Fatalities were much higher among the Paiute due to newly introduced Eurasian infectious diseases , such as smallpox , which were endemic among the Europeans. The Natives had no acquired immunity . Sarah Winnemucca 's book Life Among the Piutes (1883) gives a first-hand account of this period. The US government first established the Malheur Reservation for the Northern Paiute in eastern Oregon. It intended to concentrate

3498-422: The common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15, the first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and

3604-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that

3710-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of

3816-460: The 1770 population of the Northern Paiute within California was 500. He estimated their population in 1910 as 300. Others put the total Northern Paiute population in 1859 at about 6,000. Numic languages These languages are classified in three groups: Apart from Comanche , each of these groups contains one language spoken in a small area in the southern Sierra Nevada and valleys to

3922-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses

4028-435: The 20th century, gender roles began to shift. Men worked in seasonal jobs and the women mainly worked in laundry and medicine. The shift happened because the men that worked seasonal jobs would not have work at the end of a given season, while women had consistent work. This made women a major provider in the family. Another shift came in the shape of politics. While some women disrupted tribe meetings, Sarah Winnemucca became

4134-585: The Cannibal who kills almost all of the Indians but not the woman; Coyote is "the one who fixed things," mentioned briefly in many of the origin stories; a man and a woman who meet and bear four children; the four children who are paired off into different tribes and quarrel with the other pair. The creativity in which the stories were told is part of the reason for such an array of versions. These epic stories were first told long ago to large groups gathered around

4240-972: The Central and Western Numic languages expanded into the Great Basin. Bands of eastern Shoshoni split off from the main Shoshoni body in the very late 17th or very early 18th century and moved southeastward onto the Great Plains. Changes in their Shoshoni dialect eventually produced Comanche. The Comanche language and the Shoshoni language are quite similar although certain low-level consonant changes in Comanche have inhibited mutual intelligibility. Recent lexical and grammatical diffusion studies in Western Numic have shown that while there are clear linguistic changes that separate Northern Paiute as

4346-779: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,

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4452-705: The Nevada/California area in which they currently reside. They also may have overthrown and destroyed other Indian tribes in order to inhabit their current lands. For example, the Paiute were almost "continually at war" with the Klamath south and west of them. "The Achomawi, south of the Klamath, also were enemies of the Northern Paiute, (so much so that) the earliest wars related in Achomawi oral tradition were (with) Northern Paiute". Sustained contact between

4558-443: The Northern Paiute and European Americans began in the early 1840s, although the first contact may have occurred as early as the 1820s. Although the Paiute had adopted the use of horses from other Great Plains tribes, their culture was otherwise then largely unaffected by European influences. As Euro-American settlement of the area progressed, competition for scarce resources increased. Several violent confrontations took place, including

4664-440: The Northern Paiute community. The Northern Paiute believe that doctors/shaman retrieve the souls of those who have committed wrongdoings and re-establish them in to Native American society. They are the intermediaries between the evil acts of the sick and the goodness of the healthy tribe. For this reason, Northern Paiute do not perceive white doctors as capable of fully healing those in need because although they may be able to cure

4770-546: The Northern Paiute there, but its strategy did not work. Because of the distance of the reservation from the traditional areas of most of the bands, and because of its poor environmental conditions, many Northern Paiute refused to go there. Those that did, soon left. They clung to their traditional lifestyle as long as possible. When environmental degradation of their lands made that impossible, they sought jobs on white farms, ranches or in cities. They established small Indian colonies , where they were joined by many Shoshone and, in

4876-454: The Paiute were created and their homes established in Nevada, California, and Oregon. Another version of the creation story tells of a man and a woman who heard a voice from within a bottle. They dumped the contents of the bottle out, and four beings dropped out: two boys and two girls. The 4 people were divided by good and evil. The two good people (Paiute) were to be protected and cared for by

4982-770: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,

5088-565: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor

5194-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add

5300-443: The above changes. Forms in the daughter languages are written in a broad phonetic transcription rather than a phonemic transcription that sometimes masks the differences between the forms. Italicized vowels and sonorants are voiceless. Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus . The last naturally occurring case

5406-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing

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5512-401: The bands. Northern Paiute originally lived a seminomadic lifestyle, moving from place to place following animal migration patterns and seasonal foods. They lived in small, independent groups that consisted of a handful or so of different family units. Upon arrival of foreigners into western Nevada, the Northern Paiute became sedentary in order to protect themselves and handle negotiations with

5618-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When

5724-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate

5830-516: The characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through the smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after

5936-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized

6042-654: The clusters. Geminated stops and affricates are voiceless and non-geminated stops and affricates are voiced fricatives. The velar nasals have fallen together with the alveolar nasals. The dialects of Colorado River east of Chemehuevi have lost *h . The dialects east of Kaibab have collapsed the nasal-stop clusters with the geminated stops and affricate. Proto-Western Numic changed the nasal-stop clusters of Proto-Numic into voiced geminate stops. In Mono and all dialects of Northern Paiute except Southern Nevada, these voiced geminate stops have become voiceless. The following table shows some sample Numic cognate sets that illustrate

6148-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as

6254-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly

6360-512: The disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It was one of several diseases introduced by the Columbian exchange to

6466-465: The earliest record of Comanche from 1786, but precedes the 20th century. Geminated stops in Comanche have also become phonetically preaspirated. Proto-Southern Numic preserved the Proto-Numic consonant system fairly intact, but the individual languages have undergone several changes. Modern Kawaiisu has reanalyzed the nasal-stop clusters as voiced stops, although older recordings preserve some of

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6572-539: The east (Mono, Timbisha, and Kawaiisu), and one language spoken in a much larger area extending to the north and east (Northern Paiute, Shoshoni, and Colorado River). Some linguists have taken this pattern as an indication that Numic speaking peoples expanded quite recently from a small core, perhaps near the Owens Valley , into their current range. This view is supported by lexicostatistical studies. Fowler's reconstruction of Proto-Numic ethnobiology also points to

6678-420: The elements, plants, and animals that are a part of that physical realm. Humans are seen to be very much a part of that world, not superior or inferior, simply another component. The Northern Paiute people believe that "matter and places are pregnant in form, meaning, and relations to natural and human phenomena." This belief gave credibility and placed necessity in shamans, as it does today. In order to draw upon

6784-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to

6890-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox

6996-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,

7102-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after

7208-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in

7314-408: The malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and the first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by

7420-610: The mountains in the fall as a critical winter food source. Women also gathered grass seeds and roots as important parts of their diet. The name of each band was derived from a characteristic food source. For example, the people at Pyramid Lake were known as the Cui Ui Ticutta (meaning " Cui-ui eaters", or trout eaters). The people of the Lovelock area were known as the Koop Ticutta , meaning "ground-squirrel eaters" and

7526-451: The new settlers. Because of their change from a nomadic to a sedentary lifestyle , women were relied upon more heavily for both their full-time employment and at-home work. In some modern Northern Paiute tribes, men work in "seasonal jobs on the ranches, in the mines, and as caretakers in the nearby motels" and women work "in the laundry, the bakery, in homes and motels as domestics, and in the country hospital". They gathered Pinyon nuts in

7632-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox

7738-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox

7844-464: The other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of

7950-523: The outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series, the case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form,

8056-484: The outer shell, the inner shell will decay and be lost, leaving the person dead in reality. A shaman, however, would take an ill person (physically or spiritually ill) and use the power from the universe to heal him. In many cases, a shaman will utilize various mediums, such as a rattle, smoke, and songs, to incite the power of the universe. Estimates for the pre-contact populations of most native groups in California have varied substantially. Alfred L. Kroeber thought that

8162-769: The people of the Carson Sink were known as the Toi Ticutta meaning " tule eaters". The Kucadikadi of Mono County, California are the " brine fly eaters". Relations among the Northern Paiute and their Shoshone neighbors were generally peaceful. There is no sharp distinction between the Northern Paiute and Western Shoshone or Sosone . Relations with the Waasseoo or Washoe people, who were culturally and linguistically very different, were not so peaceful. These differences in lifestyle and language could be because Northern Paiute may have moved from southern regions to

8268-588: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of

8374-554: The powers of nature and the universe, shamans would frequently visit sacred sites. These sites can be found throughout the Great Basin and the American West. They include "mountains, caves, waterways, and unique geological formations." One such site is called the Parowan Gap and is sacred to the Paiute (see image). These sacred sites are where shamans performed many of their duties, including curing, rainmaking , warfare, fighting, or sorcery ." Shamans were and are an integral part of

8480-497: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because

8586-491: The prodromal illness still occurred but may have been less severe than in the ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)

8692-547: The region of the southern Sierra Nevada as the homeland of Proto-Numic approximately two millennia ago. A mitochondrial DNA study from 2001 supports this linguistic hypothesis. The anthropologist Peter N. Jones thinks this evidence to be of a circumstantial nature, but this is a distinctly minority opinion among specialists in Numic. David Shaul has proposed that the Southern Numic languages spread eastward long before

8798-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before

8904-479: The second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By the sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to

9010-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this

9116-427: The smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is a less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash)

9222-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There

9328-425: The temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to

9434-411: The touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week, the pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced

9540-465: The tribe chanted and acted out the stories to the beat of a drum with people dancing. The Northern Paiute origin story, among many other important and formative legends, was passed on orally from tribal elders to younger tribe members and from grandmothers and grandfathers to grandchildren. Many of their stories and much of their history is passed on orally even today. Gender roles among the Northern Paiute did not stand out in society. Men and women divided

9646-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on

9752-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox

9858-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in

9964-554: The whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on the Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and

10070-501: The woman while the two bad people were subject to the man. The two sets of pairs (good and bad) left the man and woman. Each pair created fire: the two good people made a fire with minimal smoke, the two bad people made a fire with thick smoke. This made them enemies, even before foreigners plotted them against each other later on. War and strife have existed ever since. While several other variations of these stories are told, they all share some similar events and characters. Namely Nűműzóho

10176-423: The work between each other the most traditional way: women made household tools, gathered fruit and seeds, cooked, cleaned, cared for the children, and made the clothing, while men hunted and protected their families. Men also taught their sons how to hunt and fish as a means to pass on a survival skill. Both sexes took part in storytelling, artwork and medicine, and traditional medicine. As the Northern Paiute entered

10282-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of

10388-478: Was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash . Over a number of days, the skin rash turned into

10494-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation

10600-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from

10706-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox

10812-456: Was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox, the malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and

10918-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout

11024-555: Was the phonemic split of Proto-Numic geminate consonants into geminate consonants and preaspirated consonants. The conditioning factors involve stress shifts and are complex. The preaspirated consonants surfaced as voiceless fricatives, often preceded by a voiceless vowel. Shoshoni and Comanche have both lost the velar nasals, merging them with *n or turning them into velar nasal-stop clusters. In Comanche, nasal-stop clusters have become simple stops, but p and t from these clusters do not lenite intervocalically. This change postdates

11130-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it

11236-516: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed

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