103-492: The Plachimada Coca-Cola struggle Is a series of protests to close the Coca-Cola factory in the village of Plachimada, Palakkad District , Kerala , India in the early 2000s. Villagers noted that soon after the factory opened, their wells started to run dry and the available water turned contaminated and toxic. Soon, waste from the factory was passed off to farmers in the area as fertiliser. The controversy became "one of
206-668: A Stepan Company plant in Maywood, New Jersey , the only manufacturing plant authorized by the federal government to import and process coca leaves, which it obtains from Peru and Bolivia. Stepan Company extracts cocaine from the coca leaves, which it then sells to Mallinckrodt , the only company in the United States licensed to purify cocaine for medicinal use . Long after the syrup had ceased to contain any significant amount of cocaine, in North Carolina "dope" remained
309-442: A microwave oven for 2–3 minutes before grilling shortens the time on the hot pan, and removes heterocyclic amine (HCA) precursors, which can help minimize the formation of these carcinogens. Frying, grilling or broiling food at high temperatures, especially starchy foods, until a toasted crust is formed generates acrylamides . This discovery in 2002 led to international health concerns. Subsequent research has however found that it
412-519: A book in 1950 published by Emory University . In this definitive biography about his father, Candler specifically states: "on April 14, 1888, the young druggist Asa Griggs Candler purchased a one-third interest in the formula of an almost completely unknown proprietary elixir known as Coca-Cola." The deal was actually between John Pemberton's son Charley and Walker, Candler & Co. – with John Pemberton acting as cosigner for his son. For $ 50 down and $ 500 in 30 days, Walker, Candler & Co. obtained all of
515-485: A cell's normal processes for regulating growth, leading to uncontrolled cellular proliferation. This occurs when the cell's DNA repair processes fail to identify DNA damage allowing the defect to be passed down to daughter cells . The damage accumulates over time. This is typically a multi-step process during which the regulatory mechanisms within the cell are gradually dismantled allowing for unchecked cellular division . The specific mechanisms for carcinogenic activity
618-671: A common colloquialism for Coca-Cola, and "dope-wagons" were trucks that transported it. The kola nut acts as a flavoring and the original source of caffeine in Coca-Cola. It contains about 2.0 to 3.5% caffeine, and has a bitter flavor. In 1911, the US government sued in United States v. Forty Barrels and Twenty Kegs of Coca-Cola , hoping to force the Coca-Cola Company to remove caffeine from its formula. The court found that
721-442: A contract giving them control of the procedure for only one dollar. Candler later realized that he had made a grave mistake. Candler never collected his dollar, but in 1899, Chattanooga became the site of the first Coca-Cola bottling company. Candler remained very content just selling his company's syrup. The loosely termed contract proved to be problematic for the Coca-Cola Company for decades to come. Legal matters were not helped by
824-509: A day for its production after obtaining permission from Perumatty panchayat, which was later confirmed by the Kerala High Court . Villagers living nearby the factory started reporting increased water pollution six months after the factory was opened. Accessing water for agricultural purposes became an issue. The factory had also made a practice of distributing its sludge waste from the manufacturing process as free fertilizer to
927-466: A few. CERCLA identifies all radionuclides as carcinogens, although the nature of the emitted radiation ( alpha , beta , gamma , or neutron and the radioactive strength), its consequent capacity to cause ionization in tissues, and the magnitude of radiation exposure, determine the potential hazard. Carcinogenicity of radiation depends on the type of radiation, type of exposure, and penetration. For example, alpha radiation has low penetration and
1030-792: A franchising model. The Coca-Cola Company only produces a syrup concentrate, which it sells to bottlers throughout the world, who hold Coca-Cola franchises for one or more geographical areas. The bottlers produce the final drink by mixing the syrup with filtered water and sweeteners, putting the mixture into cans and bottles, and carbonating it, which the bottlers then sell and distribute to retail stores, vending machines, restaurants, and foodservice distributors. The Coca-Cola Company owns minority shares in some of its largest franchises, such as Coca-Cola Enterprises , Coca-Cola Amatil , Coca-Cola Hellenic Bottling Company , and Coca-Cola FEMSA , as well as some smaller ones, such as Coca-Cola Bottlers Uzbekistan , but fully independent bottlers produce almost half of
1133-435: A full payment amounting to $ 1,000, which all agreed Candler could pay off with a series of notes over a specified time span. By May 1, 1889, Candler was claiming full ownership of the Coca-Cola beverage, with a total investment outlay by Candler for the drink enterprise over the years amounting to $ 2,300. In 1914, Margaret Dozier, as co-owner of the original Coca-Cola Company in 1888, came forward to claim that her signature on
SECTION 10
#17327971981681236-482: A high incidence of colon cancer. Dietary increases in total fat or saturated fat result in elevated DCA and LCA in feces and elevated exposure of the colon epithelium to these bile acids. When the bile acid DCA was added to the standard diet of wild-type mice invasive colon cancer was induced in 56% of the mice after 8 to 10 months. Overall, the available evidence indicates that DCA and LCA are centrally important DNA-damaging carcinogens in colon cancer. Stomach cancer
1339-488: A major source of carcinogens with an estimated 666,000 annual fatalities worldwide attributable to work related cancers. According to NIOSH , 3-6% of cancers worldwide are due to occupational exposures. Well established occupational carcinogens include vinyl chloride and hemangiosarcoma of the liver, benzene and leukemia , aniline dyes and bladder cancer , asbestos and mesothelioma , polycyclic aromatic hydrocarbons and scrotal cancer among chimney sweeps to name
1442-581: A medical degree and began a quest to find a substitute for the problematic drug. In 1885 at Pemberton's Eagle Drug and Chemical House, his drugstore in Columbus, Georgia , he registered Pemberton's French Wine Coca nerve tonic. Pemberton's tonic may have been inspired by the formidable success of Vin Mariani , a French- Corsican coca wine , but his recipe additionally included the African kola nut ,
1545-598: A plan to combat plastic waste , Coca-Cola said that it would start selling its sodas in bottles made from 100% recycled plastic material in the United States, and by 2030 planned to recycle one bottle or can for each one it sold. Coca-Cola started by selling 2000 paper bottles to see if they held up due to the risk of safety and of changing the taste of the drink. A typical can of Coca-Cola (12 fl ounces/355 ml) contains 39 grams of sugar, 46 mg of caffeine, 50 mg of sodium, no fat, no potassium, and 140 calories. The exact formula for Coca-Cola's natural flavorings
1648-770: A product's label. In 1913 the case was appealed to the Sixth Circuit in Cincinnati, where the ruling was affirmed, but then appealed again in 1916 to the Supreme Court, where the government effectively won as a new trial was ordered. The company then voluntarily reduced the amount of caffeine in its product, and offered to pay the government's legal costs to settle and avoid further litigation. Coca-Cola contains 46 mg of caffeine per 12 US fluid ounces (or 30.7 mg per 8 US fluid ounces (240 ml) serving). The production and distribution of Coca-Cola follows
1751-399: A typical dose or "line" of cocaine is 50–75 mg. ) In 1903, the fresh coca leaves were removed from the formula. After 1904, instead of using fresh leaves, Coca-Cola started using "spent" leaves – the leftovers of the cocaine-extraction process with trace levels of cocaine. Since then (by 1929 ), Coca-Cola has used a cocaine-free coca leaf extract. Today, that extract is prepared at
1854-541: A version that he made either before or after the product hit the market in 1886. The formula basically matched the one found in Pemberton's diary. Coca-Cola archivist Phil Mooney acknowledged that the recipe "could be a precursor" to the formula used in the original 1886 product, but emphasized that Pemberton's original formula is not the same as the one used in the modern product. When launched, Coca-Cola's two key ingredients were cocaine and caffeine . The cocaine
1957-645: A wider assessment of the occupational hazards of chemicals. The European Union classification of carcinogens is contained in the Regulation (EC) No 1272/2008. It consists of three categories: The former European Union classification of carcinogens was contained in the Dangerous Substances Directive and the Dangerous Preparations Directive . It also consisted of three categories: This assessment scheme
2060-502: Is Diet Coke , along with others including Caffeine-Free Coca-Cola , Diet Coke Caffeine-Free , Coca-Cola Zero Sugar , Coca-Cola Cherry , Coca-Cola Vanilla , and special versions with lemon , lime , and coffee . Coca-Cola was called "Coca-Cola Classic" from July 1985 to 2009, to distinguish it from " New Coke ". Confederate Colonel John Pemberton , wounded in the American Civil War and addicted to morphine , also had
2163-605: Is carcinogenic, if received in sufficient doses. For most people, ultraviolet radiations from sunlight is the most common cause of skin cancer. In Australia, where people with pale skin are often exposed to strong sunlight, melanoma is the most common cancer diagnosed in people aged 15–44 years. Substances or foods irradiated with electrons or electromagnetic radiation (such as microwave, X-ray or gamma) are not carcinogenic. In contrast, non-electromagnetic neutron radiation produced inside nuclear reactors can produce secondary radiation through nuclear transmutation . Alcohol
SECTION 20
#17327971981682266-412: Is a United Nations initiative to attempt to harmonize the different systems of assessing chemical risk which currently exist (as of March 2009) around the world. It classifies carcinogens into two categories, of which the first may be divided again into subcategories if so desired by the competent regulatory authority: The National Toxicology Program of the U.S. Department of Health and Human Services
2369-416: Is a cola soft drink manufactured by the Coca-Cola Company . In 2013, Coke products were sold in over 200 countries and territories worldwide, with consumers drinking more than 1.8 billion company beverage servings each day. Coca-Cola ranked No. 94 in the 2024 Fortune 500 list of the largest United States corporations by revenue . Based on Interbrand's "best global brand" study of 2023, Coca-Cola
2472-587: Is a trade secret . (All of its other ingredients are listed on the side of the bottle or can, and are not secret.) The original copy of the formula was held in Truist Financial 's main vault in Atlanta for 86 years. Its predecessor, the Trust Company, was the underwriter for the Coca-Cola Company's initial public offering in 1919. On December 8, 2011, the original secret formula was moved from
2575-683: Is a carcinogen of the head and neck, esophagus, liver, colon and rectum, and breast. It has a synergistic effect with tobacco smoke in the development of head and neck cancers. In the United States approximately 6% of cancers and 4% of cancer deaths are attributable to alcohol use. Chemicals used in processed and cured meat such as some brands of bacon, sausages and ham may produce carcinogens. For example, nitrites used as food preservatives in cured meat such as bacon have also been noted as being carcinogenic with demographic links, but not causation, to colon cancer. Cooking food at high temperatures, for example grilling or barbecuing meats, may also lead to
2678-764: Is a complex mixture of more than 5,300 identified chemicals. The most important carcinogens in tobacco smoke have been determined by a "Margin of Exposure" approach. Using this approach, the most important tumorigenic compounds in tobacco smoke were, in order of importance, acrolein , formaldehyde , acrylonitrile , 1,3-butadiene, cadmium, acetaldehyde, ethylene oxide, and isoprene. Most of these compounds cause DNA damage by forming DNA adducts or by inducing other alterations in DNA. DNA damages are subject to error-prone DNA repair or can cause replication errors. Such errors in repair or replication can result in mutations in tumor suppressor genes or oncogenes leading to cancer. Breast cancer
2781-707: Is an intergovernmental agency established in 1965, which forms part of the World Health Organization of the United Nations . It is based in Lyon , France . Since 1971 it has published a series of Monographs on the Evaluation of Carcinogenic Risks to Humans that have been highly influential in the classification of possible carcinogens. The Globally Harmonized System of Classification and Labelling of Chemicals (GHS)
2884-685: Is being phased out in favor of the GHS scheme (see above), to which it is very close in category definitions. Under a previous name, the NOHSC, in 1999 Safe Work Australia published the Approved Criteria for Classifying Hazardous Substances [NOHSC:1008(1999)]. Section 4.76 of this document outlines the criteria for classifying carcinogens as approved by the Australian government. This classification consists of three categories: In this section,
2987-738: Is known to cause stomach cancer and MALT lymphoma . Hepatitis B and C are associated with the development of hepatocellular cancer. HPV is the primary cause of cervical cancer . Tobacco smoke contains at least 70 known carcinogens and is implicated in the development of numerous types of cancers including cancers of the lung, larynx, esophagus, stomach, kidney, pancreas, liver, bladder, cervix, colon, rectum and blood. Potent carcinogens found in cigarette smoke include polycyclic aromatic hydrocarbons (PAH, such as benzo(a)pyrene), benzene , and nitrosamine . Given that populations of workers are more likely to have consistent, often high level exposures to chemicals rarely encountered in normal life, much of
3090-446: Is mandated to produce a biennial Report on Carcinogens . As of August 2024, the latest edition was the 15th report (2021). It classifies carcinogens into two groups: The American Conference of Governmental Industrial Hygienists (ACGIH) is a private organization best known for its publication of threshold limit values (TLVs) for occupational exposure and monographs on workplace chemical hazards. It assesses carcinogenicity as part of
3193-651: Is not a hazard outside the body, but emitters are carcinogenic when inhaled or ingested. For example, Thorotrast , a (incidentally radioactive) suspension previously used as a contrast medium in x-ray diagnostics, is a potent human carcinogen known because of its retention within various organs and persistent emission of alpha particles. Low-level ionizing radiation may induce irreparable DNA damage (leading to replicational and transcriptional errors needed for neoplasia or may trigger viral interactions) leading to pre-mature aging and cancer . Not all types of electromagnetic radiation are carcinogenic. Low-energy waves on
Plachimada Coca-Cola struggle - Misplaced Pages Continue
3296-429: Is not likely that the acrylamides in burnt or well-cooked food cause cancer in humans; Cancer Research UK categorizes the idea that burnt food causes cancer as a "myth". Several biologic agents are known carcinogens. Aflatoxin B 1 , a toxin produced by the fungus Aspergillus flavus which is a common contaminant of stored grains and nuts is a known cause of hepatocellular cancer . The bacteria H. Pylori
3399-592: Is reported to be available in both countries as a grey import . As of 2022, Coca-Cola has suspended its operations in Russia due to the invasion of Ukraine . Coca-Cola has been a point of legal discussion in the Middle East . In the early 20th century, a fatwa was created in Egypt to discuss the question of "whether Muslims were permitted to drink Coca-Cola and Pepsi cola." The fatwa states: "According to
3502-426: Is the fourth most common cancer [990,000 cases (7.8%), 738,000 deaths (9.7%)]. Helicobacter pylori infection is the main causative factor in stomach cancer. Chronic gastritis (inflammation) caused by H. pylori is often long-standing if not treated. Infection of gastric epithelial cells with H. pylori results in increased production of reactive oxygen species (ROS). ROS cause oxidative DNA damage including
3605-649: Is the most common cancer in the world, both in terms of cases (1.6 million cases; 12.7% of total cancer cases) and deaths (1.4 million deaths; 18.2% of total cancer deaths). Lung cancer is largely caused by tobacco smoke. Risk estimates for lung cancer in the United States indicate that tobacco smoke is responsible for 90% of lung cancers. Other factors are implicated in lung cancer, and these factors can interact synergistically with smoking so that total attributable risk adds up to more than 100%. These factors include occupational exposure to carcinogens (about 9-15%), radon (10%) and outdoor air pollution (1-2%). Tobacco smoke
3708-406: Is the second most common cancer [(1.4 million cases, 10.9%), but ranks 5th as cause of death (458,000, 6.1%)]. Increased risk of breast cancer is associated with persistently elevated blood levels of estrogen . Estrogen appears to contribute to breast carcinogenesis by three processes; (1) the metabolism of estrogen to genotoxic, mutagenic carcinogens, (2) the stimulation of tissue growth, and (3)
3811-788: Is toxic to human development and the nervous system, while cadmium is a documented carcinogen . Mounting pressure on the Kerala Government to shut down the factory, Greenpeace Campaign Head Ameer Shahul shared the University of Exeter analysis report to the Kerala State Pollution Control Board and to the local media, and demanded permanent closure of the factory. Soon, the Kerala State Pollution Control Board confirmed these test results and ordered The Coca-Cola Company to stop distribution of its waste and to recover what had been dispersed in
3914-834: Is unique to each agent and cell type. Carcinogens can be broadly categorized, however, as activation-dependent and activation-independent which relate to the agent's ability to engage directly with DNA. Activation-dependent agents are relatively inert in their original form, but are bioactivated in the body into metabolites or intermediaries capable of damaging human DNA. These are also known as "indirect-acting" carcinogens. Examples of activation-dependent carcinogens include polycyclic aromatic hydrocarbons (PAHs), heterocyclic aromatic amines , and mycotoxins . Activation-independent carcinogens, or "direct-acting" carcinogens, are those that are capable of directly damaging DNA without any modification to their molecular structure. These agents typically include electrophilic groups that react readily with
4017-613: The Delaware General Corporation Law . The company publicly offered 500,000 shares of the company for $ 40 a share. In 1923, his son Robert W. Woodruff was elected President of the company. Woodruff expanded the company and brought Coca-Cola to the rest of the world. Coca-Cola began distributing bottles as "Six-packs", encouraging customers to purchase the beverage for their home. During its first several decades, Coca-Cola officially wanted to be known by its full-name despite being commonly known as "Coke". This
4120-537: The Supreme Court that it does not intend to commence manufacturing operations at its plant located at Plachimada ( Palakkad district ) in Kerala . The Bench comprising Justice Rohinton Fali Nariman and Justice Sanjay Kishan Kaul made a note of the statement and in its order dated July 13, 2017, stated, “We record the aforesaid statement and, therefore, dispose of these appeals as being become infructuous in terms of
4223-522: The electromagnetic spectrum including radio waves , microwaves , infrared radiation and visible light are thought not to be, because they have insufficient energy to break chemical bonds. Evidence for carcinogenic effects of non-ionizing radiation is generally inconclusive , though there are some documented cases of radar technicians with prolonged high exposure experiencing significantly higher cancer incidence. Higher-energy radiation, including ultraviolet radiation (present in sunlight ) generally
Plachimada Coca-Cola struggle - Misplaced Pages Continue
4326-480: The "Coca-Cola Company" destroyed in 1910, the action was claimed to have been made during a move to new corporation offices around this time. On June 23, 1894, Charley Pemberton was found unconscious with a stick of opium by his side. Ten days later, Charley died at Atlanta's Grady Hospital at the age of 40. On September 12, 1919, Coca-Cola Co. was purchased by a group of investors led by Ernest Woodruff 's Trust Company for $ 25 million and reincorporated under
4429-408: The 1888 Coca-Cola Company bill of sale had been forged. Subsequent analysis of other similar transfer documents had also indicated John Pemberton's signature had most likely been forged as well, which some accounts claim was precipitated by his son Charley. In 1892, Candler set out to incorporate a second company, the Coca-Cola Company (the modern corporation). When Candler had the earliest records of
4532-406: The 20th and 21st century. The name refers to two of its original ingredients: coca leaves and kola nuts (a source of caffeine ). The formula of Coca-Cola remains a trade secret ; however, a variety of reported recipes and experimental recreations have been published. The secrecy around the formula has been used by Coca-Cola as a marketing aid because only a handful of anonymous employees know
4635-610: The Anti-Coca Cola Agitation Council at Plachimada in June 2024, who argue that the government’s action benefits Coca Cola by allowing them to avoid compensating local victims first. The council demanded that the government delay taking over the land until compensation is ensured for the damages allegedly caused by the company to the Plachimada community. Coca-Cola Coca-Cola , or Coke ,
4738-516: The Biedenharn Candy Company on March 12, 1894. The proprietor of the bottling works was Joseph A. Biedenharn . The original bottles were Hutchinson bottles, very different from the much later hobble-skirt design of 1915 now so familiar. A few years later two entrepreneurs from Chattanooga, Tennessee , namely Benjamin F. Thomas and Joseph B. Whitehead , proposed the idea of bottling and were so persuasive that Candler signed
4841-587: The Caribbean, the Netherlands , Germany and parts of Asia until the 1940s, when the brand was introduced throughout South America and then Europe after the end of World War II ( Fanta was initially conceived by the German Coca-Cola subsidiary as an emergency replacement as the wartime trade embargo prevented the import of syrup). As a result, Coca-Cola eventually became regarded as one of
4944-621: The Muslim Hanefite, Shafi'ite, etc., the rule in Islamic law of forbidding or allowing foods and beverages is based on the presumption that such things are permitted unless it can be shown that they are forbidden on the basis of the Qur'an ." The Muslim jurists stated that, unless the Qur'an specifically prohibits the consumption of a particular product, it is permissible to consume. Another clause
5047-486: The beverage's source of caffeine. A Spanish drink called "Kola Coca" was presented at a contest in Philadelphia in 1885, a year before the official birth of Coca-Cola. The rights for this Spanish drink were bought by Coca-Cola in 1953. In 1886, when Atlanta and Fulton County passed prohibition legislation, Pemberton responded by developing Coca-Cola, a non-alcoholic version of Pemberton's French Wine Coca . It
5150-729: The bile acids deoxycholic acid (DCA) or lithocholic acid (LCA) induce production of DNA-damaging reactive oxygen species or reactive nitrogen species in human or animal colon cells. Furthermore, 14 studies showed that DCA and LCA induce DNA damage in colon cells. Also 27 studies reported that bile acids cause programmed cell death ( apoptosis ). Increased apoptosis can result in selective survival of cells that are resistant to induction of apoptosis. Colon cells with reduced ability to undergo apoptosis in response to DNA damage would tend to accumulate mutations, and such cells may give rise to colon cancer. Epidemiologic studies have found that fecal bile acid concentrations are increased in populations with
5253-593: The business, as well. John Pemberton died suddenly on August 16, 1888. Asa Candler then decided to move swiftly forward to attain full control of the entire Coca-Cola operation. Charley Pemberton, an alcoholic and opium addict, unnerved Asa Candler more than anyone else. Candler is said to have quickly maneuvered to purchase the exclusive rights to the name "Coca-Cola" from Pemberton's son Charley immediately after he learned of Dr. Pemberton's death. One of several stories states that Candler approached Charley's mother at John Pemberton's funeral and offered her $ 300 in cash for
SECTION 50
#17327971981685356-750: The carcinogenicity of substances include the National Toxicology Program of the US Public Health Service , NIOSH , the American Conference of Governmental Industrial Hygienists and others. There are numerous sources of exposures to carcinogens including ultraviolet radiation from the sun, radon gas emitted in residential basements, environmental contaminants such as chlordecone , cigarette smoke and ingestion of some types of foods such as alcohol and processed meats . Occupational exposures represent
5459-422: The carcinogens implicated as the main causative agents of the four most common cancers worldwide are briefly described. These four cancers are lung, breast, colon, and stomach cancers. Together they account for about 41% of worldwide cancer incidence and 42% of cancer deaths (for more detailed information on the carcinogens implicated in these and other cancers, see references ). Lung cancer (pulmonary carcinoma)
5562-449: The community via trucks and to start rainwater harvesting programs at the factory and in the community. As the villagers maintained the protest outside the factory, support grew for the movement. In January 2004, a three-day International Water Conference at Plachimada was organized to bring together activists from around the world to discuss water issues. Two environmentalists , Canadian Maude Barlow and Indian Vandana Shiva , attended
5665-405: The company made minor changes in the sourcing of some ingredients so it could continue to be consumed by America's Jewish population, including during Passover . A yellow cap on a Coca-Cola drink indicates that it is kosher for Passover . The longest running commercial Coca-Cola soda fountain anywhere was Atlanta's Fleeman's Pharmacy, which first opened its doors in 1914. Jack Fleeman took over
5768-461: The company was granted permission to open the factory. The firm purchased a roughly 34.64-acre (14.02 ha) plot, which had previously been used to cultivate paddy , peanuts and vegetables. The factory employed 130 permanent workers and approximately 250 temporary laborers. Brands produced at the Plachimada factory included Coca-Cola , Limca , Fanta , Thums Up , Sprite , Kinley Soda , and Maaza . The factory used 500,000 litres of groundwater
5871-608: The conference and issued the Plachimada Declaration stating that "water is not a private property, not a commodity" but a common resource and a fundamental right. On 3 April 2003, the Perumatty panchayat revoked the license for the plant. Coca-Cola took the case to the Kerala High Court , which at first sided with the firm, saying the panchayat's claims were unscientific and unfounded. The legal battle lasted years. At times, for example, between 8 and 15 August 2005,
5974-654: The cumulative scientific evidence regarding the potential carcinogenicity of specific substances. Foremost among these is the International Agency for Research on Cancer (IARC). IARC routinely publishes monographs in which specific substances are evaluated for their potential carcinogenicity to humans and subsequently categorized into one of four groupings: Group 1: Carcinogenic to humans, Group 2A: Probably carcinogenic to humans, Group 2B: Possibly carcinogenic to humans and Group 3: Not classifiable as to its carcinogenicity to humans. Other organizations that evaluate
6077-522: The decision of the bottlers to subcontract to other companies, effectively becoming parent bottlers. This contract specified that bottles would be sold at 5¢ each and had no fixed duration, leading to the fixed price of Coca-Cola from 1886 to 1959 . The first outdoor wall advertisement that promoted the Coca-Cola drink was painted in 1894 in Cartersville, Georgia . Cola syrup was sold as an over-the-counter dietary supplement for upset stomach. By
6180-478: The entire formula, and that persons other than the prescribed duo have known the formulation process. On February 11, 2011, Ira Glass said on his PRI radio show, This American Life , that his staffers had found a recipe in "Everett Beal's Recipe Book", reproduced in the February 28, 1979 issue of The Atlanta Journal-Constitution , that they believed was either Pemberton's original formula for Coca-Cola or
6283-737: The evidence for the carcinogenicity of specific agents is derived from studies of workers. Selected carcinogens Not in widespread use, but found in: circadian disruption Carcinogens can be classified as genotoxic or nongenotoxic. Genotoxins cause irreversible genetic damage or mutations by binding to DNA . Genotoxins include chemical agents like N-nitroso-N-methylurea (NMU) or non-chemical agents such as ultraviolet light and ionizing radiation . Certain viruses can also act as carcinogens by interacting with DNA. Nongenotoxins do not directly affect DNA but act in other ways to promote growth. These include hormones and some organic compounds. The International Agency for Research on Cancer (IARC)
SECTION 60
#17327971981686386-543: The form of high-fructose corn syrup in North America). The bottlers then sell, distribute, and merchandise Coca-Cola to retail stores, restaurants, and vending machines throughout the world. The Coca-Cola Company also sells concentrate for soda fountains of major restaurants and foodservice distributors . The Coca-Cola Company has on occasion introduced other cola drinks under the Coke name. The most common of these
6489-438: The formation of minute quantities of many potent carcinogens that are comparable to those found in cigarette smoke (i.e., benzo[ a ]pyrene ). Charring of food looks like coking and tobacco pyrolysis , and produces carcinogens. There are several carcinogenic pyrolysis products, such as polynuclear aromatic hydrocarbons, which are converted by human enzymes into epoxides , which attach permanently to DNA. Pre-cooking meats in
6592-515: The formula. The drink has inspired imitators and created a whole classification of soft drink: colas. The Coca-Cola Company produces concentrate , which is then sold to licensed Coca-Cola bottlers throughout the world. The bottlers, who hold exclusive territory contracts with the company, produce the finished product in cans and bottles from the concentrate, in combination with filtered water and sweeteners. A typical 12-US-fluid-ounce (350 ml) can contains 38 grams (1.3 oz) of sugar (usually in
6695-479: The health, and Pemberton's new drink was marketed and sold as a patent medicine , Pemberton claiming it a cure for many diseases, including morphine addiction, indigestion, nerve disorders, headaches, and impotence . Pemberton ran the first advertisement for the beverage on May 29 of the same year in the Atlanta Journal . By 1888, three versions of Coca-Cola – sold by three separate businesses – were on
6798-558: The incidence of DNA damage and breast cancer risk. Consumption of alcohol has also been linked to an increased risk for breast cancer. Colorectal cancer is the third most common cancer [1.2 million cases (9.4%), 608,000 deaths (8.0%)]. Tobacco smoke may be responsible for up to 20% of colorectal cancers in the United States. In addition, substantial evidence implicates bile acids as an important factor in colon cancer. Twelve studies (summarized in Bernstein et al. ) indicate that
6901-484: The legal role of local government. The wells are still contaminated and water must be piped in from a nearby village. A High Powered Committee has determined that the damage to the community amounts to ₹ 216.26 crores or ( $ 28 million). This figure was broken down into categories of agriculture loss, health damage, cost of providing water, wage loss and opportunity cost and the cost of pollution of water resources. However, as of 2018, no compensation has been paid to
7004-418: The major base alteration 8-hydroxydeoxyguanosine (8-OHdG). 8-OHdG resulting from ROS is increased in chronic gastritis. The altered DNA base can cause errors during DNA replication that have mutagenic and carcinogenic potential. Thus H. pylori -induced ROS appear to be the major carcinogens in stomach cancer because they cause oxidative DNA damage leading to carcinogenic mutations. Diet is also thought to be
7107-481: The major symbols of American soft power as well as of globalization. Since it announced its intention to begin distribution in Myanmar in June 2012, Coca-Cola has been officially available in every country in the world except Cuba (where it stopped being available officially since 1960—ironically, Coca-Cola's first bottling plant outside the United States was established there in 1906) and North Korea . However, it
7210-452: The market. A co-partnership had been formed on January 14, 1888, between Pemberton and four Atlanta businessmen: J.C. Mayfield , A.O. Murphey, C.O. Mullahy, and E.H. Bloodworth. Not codified by any signed document, a verbal statement given by Asa Candler years later asserted under testimony that he had acquired a stake in Pemberton's company as early as 1887. John Pemberton declared that the name "Coca-Cola" belonged to his son, Charley, but
7313-510: The most studied corporate controversies" in recent times. The Hindustan Coca-Cola Beverage (HCCB) is an Indian bottling entity of The Coca-Cola. Its Plachimada plant was launched and became operational in 2000. The 34.64 acres of HCCB factory produced beverages Limca , Fanta , Thums Up , Sprite , Kinley and Maaza etc. Over 400 residents were provided direct employment. The factory was closed from 2004 to May 2021 following local agitations. In July 2017, Hindustan Coca-Cola Beverages informed
7416-409: The name "Coca-Cola Classic" was changed back to "Coca-Cola". The word "Classic" was removed because "New Coke" was no longer in production, eliminating the need to differentiate between the two. The formula remained unchanged. In January 2009, Coca-Cola stopped printing the word "Classic" on the labels of 16-US-fluid-ounce (470 ml) bottles sold in parts of the southeastern United States. The change
7519-601: The name "Coke" in 1941. "Coke" eventually became a registered trademark of the Coca-Cola Company in 1945. In 1986, the Coca-Cola Company merged with two of their bottling operators (owned by JTL Corporation and BCI Holding Corporation) to form Coca-Cola Enterprises Inc. (CCE). In December 1991, Coca-Cola Enterprises merged with the Johnston Coca-Cola Bottling Group, Inc. The first bottling of Coca-Cola occurred in Vicksburg, Mississippi , at
7622-419: The names "Yum Yum" and "Koke". This was while Charley Pemberton was selling the elixir, although a cruder mixture, under the name "Coca-Cola", all with his father's blessing. After both names failed to catch on for Candler, by the middle of 1888, the Atlanta pharmacist was quite anxious to establish a firmer legal claim to Coca-Cola, and hoped he could force his two competitors, Walker and Dozier, completely out of
7725-569: The net negative charge of DNA molecules. Examples of activation-independent carcinogens include ultraviolet light , ionizing radiation and alkylating agents . The time from exposure to a carcinogen to the development of cancer is known as the latency period . For most solid tumors in humans the latency period is between 10 and 40 years depending on cancer type. For blood cancers, the latency period may be as short as two. Due to prolonged latency periods identification of carcinogens can be challenging. A number of organizations review and evaluate
7828-597: The old drink, leading to a backlash . The company gave in to protests and returned to the old formula under the name Coca-Cola Classic, on July 10, 1985. "New Coke" remained available and was renamed Coke II in 1992; it was discontinued in 2002. On July 5, 2005, it was revealed that Coca-Cola would resume operations in Iraq for the first time since the Arab League boycotted the company in 1968. In April 2007, in Canada,
7931-528: The one-third interest in the Coca-Cola Company that Charley held, all while Charley still held on to the name. After the April 14 deal, on April 17, 1888, one-half of the Walker/Dozier interest shares were acquired by Candler for an additional $ 750. After Candler had gained a better foothold on Coca-Cola in April 1888, he nevertheless was forced to sell the beverage he produced with the recipe he had under
8034-523: The ones in Tucson, Arizona ) additionally sell imported Coca-Cola from Mexico with cane sugar instead of corn syrup from separate distributors. Coca-Cola introduced the 7.5-ounce mini-can in 2009, and on September 22, 2011, the company announced price reductions, asking retailers to sell eight-packs for $ 2.99. That same day, Coca-Cola announced the 12.5-ounce bottle, to sell for 89 cents. A 16-ounce bottle has sold well at 99 cents since being re-introduced, but
8137-575: The other two manufacturers could continue to use the formula . Charley Pemberton's record of control over the "Coca-Cola" name was the underlying factor that allowed for him to participate as a major shareholder in the March 1888 Coca-Cola Company incorporation filing made in his father's place. Charley's exclusive control over the "Coca-Cola" name became a continual thorn in Asa Candler's side. Candler's oldest son, Charles Howard Candler , authored
8240-506: The past. After mounting evidence that The Coca-Cola Company was polluting the environment and harming local citizens, the Coca-Cola Virudha Janakeeya Samara Samithy (Anti-Coca-Cola Peoples Struggle Committee) launched their protests on 22 April 2002 by blocking the entrance to the factory. Over 1,300 people participated in this protest, mostly Adivasis and women. Scientific tests were conducted on
8343-424: The people of Plachimada to shut down the factory in March 2004. While a government committee estimated the damages to be around ₹ 216 crore ( $ 30 million), compensation has yet to be paid to the villagers. On 8 October 1999, Hindustan Coca-Cola Beverages Private (HCBLP), a subsidiary of the Coca-Cola Company, applied for a license at Perumatty panchayat to establish a factory in Plachimada. On 27 January 2000
8446-399: The pharmacy from his father and ran it until 1995; closing it after 81 years. On July 12, 1944, the one-billionth gallon of Coca-Cola syrup was manufactured by the Coca-Cola Company. Cans of Coke first appeared in 1955. Sugar prices spiked in the 1970s because of Soviet demand/hoarding and possible futures contracts market manipulation. The Soviet Union was the largest producer of sugar at
8549-418: The plant operated, but eventually, the plant was closed permanently, after Coca-Cola declared it had no plans to restart bottling operations. In 2018, the factory sat empty with a few security guards. In 2019, Coca-Cola submitted a proposal to turn the plant into a training center for local farmers. The case was said to turn upon the legal doctrines of public trust and the polluter pays principle , as well as
8652-588: The price was going up to $ 1.19. In 2012, Coca-Cola resumed business in Myanmar after 60 years of absence due to US-imposed investment sanctions against the country. Coca-Cola's bottling plant is located in Yangon and is part of the company's five-year plan and $ 200 million investment in Myanmar. Coca-Cola with its partners is to invest US$ 5 billion in its operations in India by 2020. In February 2021, as
8755-690: The repression of phase II detoxification enzymes that metabolize ROS leading to increased oxidative DNA damage. The major estrogen in humans, estradiol , can be metabolized to quinone derivatives that form adducts with DNA. These derivatives can cause depurination, the removal of bases from the phosphodiester backbone of DNA, followed by inaccurate repair or replication of the apurinic site leading to mutation and eventually cancer. This genotoxic mechanism may interact in synergy with estrogen receptor-mediated, persistent cell proliferation to ultimately cause breast cancer. Genetic background, dietary practices and environmental factors also likely contribute to
8858-428: The rights to the name. In Charles Howard Candler's 1950 book about his father, he stated: "On August 30 [1888], he [ Asa Candler ] became the sole proprietor of Coca-Cola, a fact which was stated on letterheads, invoice blanks and advertising copy." With this action on August 30, 1888, Candler's sole control became technically all true. Candler had negotiated with Margaret Dozier and her brother Woolfolk Walker
8961-652: The signed order.” The court was hearing seven civil appeals on the issue. The petitioners’ counsels decided not to oppose the issue. In June 2021, as the Govt of Kerala approached the company, the factory was converted into a Covid First Line treatment center (CFLTC). On 22 April 2002, the villagers, mostly Adivasi , began to protest in front of the factory by blocking its entrance. The impromptu protest continued and lasted for years, by gathering support from environmental groups, locals and national political parties and activists. Continued protests and litigation eventually helped
9064-474: The syrup, when diluted as directed, would result in a beverage containing 1.21 grains (or 78.4 mg) of caffeine per 8 US fluid ounces (240 ml) serving. The case was decided in favor of the Coca-Cola Company at the district court, but subsequently in 1912, the US Pure Food and Drug Act was amended, adding caffeine to the list of "habit-forming" and "deleterious" substances which must be listed on
9167-468: The time of its 50th anniversary, the soft drink had reached the status of a national icon in the US. In 1935, it was certified kosher by Atlanta rabbi Tobias Geffen . With the help of Harold Hirsch, Geffen was the first person outside the company to see the top-secret ingredients list after Coke faced scrutiny from the American Jewish population regarding the drink's kosher status. Consequently,
9270-403: The time. In 1974 Coca-Cola switched over to high-fructose corn syrup because of the elevated prices. On April 23, 1985, Coca-Cola, amid much publicity, attempted to change the formula of the drink with "New Coke". Follow-up taste tests revealed most consumers preferred the taste of New Coke to both old Coke and Pepsi but Coca-Cola management was unprepared for the public's nostalgia for
9373-429: The vault at SunTrust Banks into a new vault; this vault will be on display for visitors to its World of Coca-Cola museum in downtown Atlanta. According to Snopes , a popular myth states that only two executives have access to the formula, with each executive having only half the formula. However, several sources state that while Coca-Cola does have a rule restricting access to only two executives, each of them knows
9476-553: The villagers. In 2017, the Supreme Court of India dismissed all appeals concerning the Coca-Cola bottling plant in Plachimada after Hindustan Coca-Cola Beverages stated that it did not plan to resume operations there. Attempts to raise compensation issues in court have been unsuccessful, and Coca-Cola’s decision to halt operations prevented further legal consideration on this matter. The Kerala government took over 35 acres of land from Coca Cola in Perumatty, with permission from Hindustan Coca Cola Beverages. This move sparked protests from
9579-521: The villagers. In 2003, a BBC journalist visited the village to investigate the claims made by the villagers that the sludge was contaminated. As part of his reporting for BBC Radio 4's Face the Facts , he has picked up samples of the sludge and sent to the United Kingdom to be analyzed. A lab at the University of Exeter found unacceptably high levels of cadmium and lead in the sludge. Lead
9682-592: The volume sold in the world. Independent bottlers are allowed to sweeten the drink according to local tastes. Coca-Cola has been sold outside the United States as early as 1900, when the Cuba Libre (a mix between Coca-Cola and rum) was created in Havana shortly after the Spanish-American War of 1898. However, the international reach of the product became mostly limited to North and Central America,
9785-475: The water by Sargram Metals Laboratories in March 2002 which deemed the water unfit for "human consumption, domestic use and for irrigation." The independent report was backed up by the government primary health center which also reported that the water was not potable in May 2003. Coca-Cola eventually admitted that there was an issue with the water, unrelated to their activities, and offered to provide drinking water to
9888-424: The wax tadpole". In the 1930s, the company settled on the name " 可口可樂 （ 可口可乐 ）" (Ke-kou ke-le) taking into account the effects of syllable and meaning translations. The phrase means roughly "to allow the mouth to be able to rejoice". The story introduction from Coca-Cola mentions that Chiang Yee provided the new localized name, but there are also sources that the localized name appeared before 1935, or that it
9991-473: Was derived from the coca leaf and the caffeine from kola nut (also spelled "cola nut" at the time), leading to the name Coca-Cola. Pemberton called for five ounces of coca leaf per gallon of syrup (approximately 37 g/L), a significant dose; in 1891, Candler claimed his formula (altered extensively from Pemberton's original) contained only a tenth of this amount. Coca-Cola once contained an estimated nine milligrams of cocaine per glass. (For comparison,
10094-501: Was discussed, whereby the same rules apply if a person is unaware of the condition or ingredients of the item in question. Coca-Cola first entered the Chinese market in the 1920s with no localized representation of its name. While the company researched a satisfactory translation, local shopkeepers created their own. These produced the desired "ko-ka ko-la" sound, but with odd meanings such as "female horse fastened with wax" or "bite
10197-551: Was due to company fears that the term "coke" would eventually become a generic trademark , which to an extent became true in the Southern United States where "coke" is used even for non Coca-Cola products . The company also didn't want to confuse its drink with the similarly named coal byproduct that clearly wasn't safe to consume. Eventually, out for fears that another company may claim the trademark for "Coke", Coca-Cola finally embraced it and officially endorsed
10300-598: Was given by someone named Jerome T. Lieu who studied at Columbia University in New York . Carcinogen A carcinogen ( / k ɑːr ˈ s ɪ n ə dʒ ən / ) is any agent that promotes the development of cancer . Carcinogens can include synthetic chemicals , naturally occurring substances, physical agents such as ionizing and non-ionizing radiation , and biologic agents such as viruses and bacteria . Most carcinogens act by creating mutations in DNA that disrupt
10403-407: Was marketed as "Coca-Cola: The temperance drink", which appealed to many people as the temperance movement enjoyed wide support during this time. The first sales were at Jacob's Pharmacy in Atlanta, Georgia, on May 8, 1886, where it initially sold for five cents a glass. Drugstore soda fountains were popular in the United States at the time due to the belief that carbonated water was good for
10506-435: Was part of a larger strategy to rejuvenate the product's image. The word "Classic" was removed from all Coca-Cola products by 2011. In November 2009, due to a dispute over wholesale prices of Coca-Cola products, Costco stopped restocking its shelves with Coke and Diet Coke for two months; a separate pouring rights deal in 2013 saw Coke products removed from Costco food courts in favor of Pepsi. Some Costco locations (such as
10609-462: Was the world's sixth most valuable brand . Originally marketed as a temperance drink and intended as a patent medicine , Coca-Cola was invented in the late 19th century by John Stith Pemberton in Atlanta , Georgia. In 1888, Pemberton sold the ownership rights to Asa Griggs Candler , a businessman, whose marketing tactics led Coca-Cola to its dominance of the global soft-drink market throughout
#167832