101-510: Rice-A-Roni is a boxed food mix that consists of rice , vermicelli pasta, and seasonings . To prepare, the rice and pasta are browned in butter, then water and seasonings are added and simmered until absorbed. It is a product of Quaker Oats Company , a subsidiary of PepsiCo . In 1890, Italian-born immigrant Domenico DeDomenico moved to California , where he established a fresh produce store. A successful businessman, he married Maria Ferrigno from Salerno , Italy . Back home, her family owned
202-491: A herbicide ), reduction of spoilage, or improving the nutrient profile of the crop. Examples in non-food crops include production of pharmaceutical agents , biofuels , and other industrially useful goods, as well as for bioremediation . Farmers have widely adopted GM technology. Between 1996 and 2011, the total surface area of land cultivated with GM crops had increased by a factor of 94, from 17,000 to 1,600,000 square kilometers (4,200,000 to 395,400,000 acres). 10% of
303-474: A plasmid vector inserted into the bacterium Escherichia coli . Insulin, widely used for the treatment of diabetes, was previously extracted from the pancreas of abattoir animals (cattle or pigs). The genetically engineered bacteria are able to produce large quantities of synthetic human insulin at relatively low cost. Biotechnology has also enabled emerging therapeutics like gene therapy . The application of biotechnology to basic science (for example through
404-416: A sustainable way. Many varieties of rice have been bred to improve crop quality and productivity. Biotechnology has created Green Revolution rice able to produce high yields when supplied with nitrogen fertiliser and managed intensively. Other products are rice able to express human proteins for medicinal use; flood-tolerant or deepwater rice ; and drought-tolerant and salt-tolerant varieties. Rice
505-698: A Unified Database System) database is intended to help companies, interested private users and competent authorities to find precise information on the presence, detection and identification of GMOs used in the European Union . The information is provided in English. In 1988, after prompting from the United States Congress , the National Institute of General Medical Sciences ( National Institutes of Health ) (NIGMS) instituted
606-461: A bacterium (of the genus Pseudomonas ) capable of breaking down crude oil, which he proposed to use in treating oil spills. (Chakrabarty's work did not involve gene manipulation but rather the transfer of entire organelles between strains of the Pseudomonas bacterium). The MOSFET invented at Bell Labs between 1955 and 1960, Two years later, Leland C. Clark and Champ Lyons invented
707-403: A branched inflorescence which arises from the last internode on the stem. There can be up to 350 spikelets in a panicle, each containing male and female flower parts ( anthers and ovule ). A fertilised ovule develops into the edible grain or caryopsis . Rice is a cereal belonging to the family Poaceae . As a tropical crop, it can be grown during the two distinct seasons (dry and wet) of
808-438: A child's parentage (genetic mother and father) or in general a person's ancestry . In addition to studying chromosomes to the level of individual genes, genetic testing in a broader sense includes biochemical tests for the possible presence of genetic diseases, or mutant forms of genes associated with increased risk of developing genetic disorders. Genetic testing identifies changes in chromosomes , genes, or proteins. Most of
909-413: A consortium could be used as industrial microbes to produce precursors of the chemotherapeutic agent paclitaxel by applying the metabolic engineering in a co-culture approach to exploit the benefits from the two microbes. Another example of synthetic biology applications in industrial biotechnology is the re-engineering of the metabolic pathways of E. coli by CRISPR and CRISPRi systems toward
1010-422: A drug's efficacy or toxicity . The purpose of pharmacogenomics is to develop rational means to optimize drug therapy, with respect to the patients' genotype , to ensure maximum efficacy with minimal adverse effects . Such approaches promise the advent of " personalized medicine "; in which drugs and drug combinations are optimized for each individual's unique genetic makeup. Biotechnology has contributed to
1111-410: A food source into another form. Before the time of Charles Darwin 's work and life, animal and plant scientists had already used selective breeding. Darwin added to that body of work with his scientific observations about the ability of science to change species. These accounts contributed to Darwin's theory of natural selection. For thousands of years, humans have used selective breeding to improve
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#17327913478451212-417: A funding mechanism for biotechnology training. Universities nationwide compete for these funds to establish Biotechnology Training Programs (BTPs). Each successful application is generally funded for five years then must be competitively renewed. Graduate students in turn compete for acceptance into a BTP; if accepted, then stipend, tuition and health insurance support are provided for two or three years during
1313-536: A harmful microbe are examples of environmental implications of biotechnology. Many cities have installed CityTrees , which use biotechnology to filter pollutants from urban atmospheres. The regulation of genetic engineering concerns approaches taken by governments to assess and manage the risks associated with the use of genetic engineering technology, and the development and release of genetically modified organisms (GMO), including genetically modified crops and genetically modified fish . There are differences in
1414-415: A notable advance in comparison with the lack of studies published in recent years in scientific journals by those companies. Krimsky, Sheldon (2015). "An Illusory Consensus behind GMO Health Assessment". Science, Technology, & Human Values . 40 (6): 883–914. doi : 10.1177/0162243915598381 . S2CID 40855100 . I began this article with the testimonials from respected scientists that there
1515-513: A number of articles some of which have strongly and negatively influenced the public opinion on GM crops and even provoked political actions, such as GMO embargo, share common flaws in the statistical evaluation of the data. Having accounted for these flaws, we conclude that the data presented in these articles does not provide any substantial evidence of GMO harm. The presented articles suggesting possible harm of GMOs received high public attention. However, despite their claims, they actually weaken
1616-434: A number of ecological benefits, if not used in excess. Insect-resistant crops have proven to lower pesticide usage, therefore reducing the environmental impact of pesticides as a whole. However, opponents have objected to GM crops per se on several grounds, including environmental concerns, whether food produced from GM crops is safe, whether GM crops are needed to address the world's food needs, and economic concerns raised by
1717-543: A pasta factory, so in 1912 she persuaded him to establish a similar business in the Mission District of San Francisco . The enterprise was " Gragnano Products, Inc." It delivered pasta to Italian stores and restaurants in the area. DeDomenico's sons, Paskey, Vince (1915–2007), Tom, and Anthony, worked with him. In 1934, Paskey changed the name to "Golden Grain Macaroni Company". Tom's wife, Lois,
1818-602: A promising method to combat malnutrition in India and other countries. Industrial biotechnology (known mainly in Europe as white biotechnology) is the application of biotechnology for industrial purposes, including industrial fermentation . It includes the practice of using cells such as microorganisms , or components of cells like enzymes , to generate industrially useful products in sectors such as chemicals, food and feed, detergents, paper and pulp, textiles and biofuels . In
1919-478: A pure microbiological culture in an industrial process, that of manufacturing corn starch using Clostridium acetobutylicum , to produce acetone , which the United Kingdom desperately needed to manufacture explosives during World War I . Biotechnology has also led to the development of antibiotics. In 1928, Alexander Fleming discovered the mold Penicillium . His work led to the purification of
2020-411: A role in various religions and traditions, such as in weddings . The rice plant can grow to over 1 m (3 ft) tall; if in deep water, it can reach a length of 5 m (16 ft). A single plant may have several leafy stems or tillers . The upright stem is jointed with nodes along its length; a long slender leaf arises from each node. The self-fertile flowers are produced in a panicle ,
2121-462: A single domestication event for O. sativa . Both indica and japonica forms of Asian rice sprang from a single domestication event in China from the wild rice Oryza rufipogon . Despite this evidence, it appears that indica rice arose when japonica arrived in India about 4,500 years ago and hybridised with another rice, whether an undomesticated proto- indica or wild O. nivara . Rice
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#17327913478452222-414: A wide range of procedures for modifying living organisms for human purposes, going back to domestication of animals, cultivation of plants, and "improvements" to these through breeding programs that employ artificial selection and hybridization . Modern usage also includes genetic engineering, as well as cell and tissue culture technologies. The American Chemical Society defines biotechnology as
2323-440: A wide variety of pests including insects, nematodes, rodents such as rats, snails, and birds. Major rice insect pests include armyworms, rice bugs , black bugs , cutworms, field crickets, grasshoppers, leafhoppers, mealybugs, and planthoppers. High rates of nitrogen fertiliser application may worsen aphid outbreaks. Weather conditions can contribute to pest outbreaks: rice gall midge outbreaks are worsened by high rainfall in
2424-436: Is rainfed like wheat or maize. Across Asia, unmilled rice or "paddy" (Indonesian and Malay padi ), was traditionally the product of smallholder agriculture, with manual harvesting . Larger farms make use of machines such as combine harvesters to reduce the input of labour. The grain is ready to harvest when the moisture content is 20–25%. Harvesting involves reaping , stacking the cut stalks, threshing to separate
2525-678: Is 69% water, 29% carbohydrates , 2% protein , and contains negligible fat (table). In a reference serving of 100 grams (3.5 oz), cooked white rice provides 130 calories of food energy , and contains moderate levels of manganese (18% DV), with no other micronutrients in significant content (all less than 10% of the Daily Value ). In 2018, the World Health Organization strongly recommended fortifying rice with iron , and conditionally recommended fortifying it with vitamin A and with folic acid . Golden rice
2626-627: Is a major food staple in Asia, Latin America, and some parts of Africa, feeding over half the world's population. However, a substantial part of the crop can be lost post-harvest through inefficient transportation, storage, and milling. A quarter of the crop in Nigeria is lost after harvest. Storage losses include damage by mould fungi if the rice is not dried sufficiently. In China, losses in modern metal silos were just 0.2%, compared to 7–13% when rice
2727-507: Is a rapidly evolving field with significant potential to address pressing global challenges and improve the quality of life for people around the world; however, despite its numerous benefits, it also poses ethical and societal challenges, such as questions around genetic modification and intellectual property rights . As a result, there is ongoing debate and regulation surrounding the use and application of biotechnology in various industries and fields. The concept of biotechnology encompasses
2828-504: Is a variety produced through genetic engineering to synthesize beta-carotene , a precursor of vitamin A, in the endosperm of the rice grain. It is intended to be grown and eaten in parts of the world where Vitamin A deficiency is prevalent. Golden rice has been opposed by activists, such as in the Philippines . In 2016 more than 100 Nobel laureates encouraged the use of genetically modified organisms , such as golden rice, for
2929-581: Is based on four principles: biodiversity, host plant resistance, landscape ecology, and hierarchies in a landscape—from biological to social. Farmers' pesticide applications are often unnecessary. Pesticides may actually induce resurgence of populations of rice pests such as the brown planthopper , both by destroying beneficial insects and by enhancing the pest's reproduction. The International Rice Research Institute (IRRI) demonstrated in 1993 that an 87.5% reduction in pesticide use can lead to an overall drop in pest numbers. Farmers in China, Indonesia and
3030-635: Is based on the basic biological sciences (e.g., molecular biology , biochemistry , cell biology , embryology , genetics , microbiology ) and conversely provides methods to support and perform basic research in biology. Biotechnology is the research and development in the laboratory using bioinformatics for exploration, extraction, exploitation, and production from any living organisms and any source of biomass by means of biochemical engineering where high value-added products could be planned (reproduced by biosynthesis , for example), forecasted, formulated, developed, manufactured, and marketed for
3131-638: Is considered one of the essential cornerstones in industrial biotechnology due to its financial and sustainable contribution to the manufacturing sector. Jointly biotechnology and synthetic biology play a crucial role in generating cost-effective products with nature-friendly features by using bio-based production instead of fossil-based. Synthetic biology can be used to engineer model microorganisms , such as Escherichia coli , by genome editing tools to enhance their ability to produce bio-based products, such as bioproduction of medicines and biofuels . For instance, E. coli and Saccharomyces cerevisiae in
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3232-865: Is expected to be good news for the biotechnology sector, with the Department of Energy estimating ethanol usage could reduce U.S. petroleum-derived fuel consumption by up to 30% by 2030. The biotechnology sector has allowed the U.S. farming industry to rapidly increase its supply of corn and soybeans—the main inputs into biofuels—by developing genetically modified seeds that resist pests and drought. By increasing farm productivity, biotechnology boosts biofuel production. Biotechnology has applications in four major industrial areas, including health care (medical), crop production and agriculture, non-food (industrial) uses of crops and other products (e.g., biodegradable plastics , vegetable oil , biofuels ), and environmental uses. For example, one application of biotechnology
3333-508: Is from Asia. The average world yield for rice was 4.7 metric tons per hectare (2.1 short tons per acre), in 2022. Yuan Longping of China's National Hybrid Rice Research and Development Center set a world record for rice yield in 1999 at 17.1 metric tons per hectare (7.6 short tons per acre) on a demonstration plot. This employed specially developed hybrid rice and the System of Rice Intensification (SRI), an innovation in rice farming. Rice
3434-572: Is literally no scientific controversy over the health effects of GMOs. My investigation into the scientific literature tells another story. And contrast: Panchin, Alexander Y.; Tuzhikov, Alexander I. (January 14, 2016). "Published GMO studies find no evidence of harm when corrected for multiple comparisons". Critical Reviews in Biotechnology . 37 (2): 213–217. doi : 10.3109/07388551.2015.1130684 . ISSN 0738-8551 . PMID 26767435 . S2CID 11786594 . Here, we show that
3535-604: Is loosely based on the Levantine pilaf dish rizz bi-sha'riyya . After a trip to Italy in 1964, Vince returned with the idea for "Noodle Roni Parmesano", based on the classic Noodles Alfredo . As the product line extended with other shapes and sauces it was renamed from Noodle Roni to Pasta Roni in 1995. In 1986, Quaker Oats Company purchased the Golden Grain Company from the DeDomenico family. In 2001,
3636-812: Is sister to the bamboos, Bambusoideae , and the cereal subfamily Pooideae . The rice genus Oryza is one of eleven in the Oryzeae; it is sister to the Phyllorachideae . The edible rice species O. sativa and O. glaberrima are among some 300 species or subspecies in the genus. other grasses (inc. the C4 grasses , maize , sorghum ) Streptogyneae Ehrharteae Phyllorachideae Wild rices inc. Zizania other rice species and subspecies O. sativa (Asian rice) O. glaberrima (African rice) Bambusoideae (bamboos) Pooideae (grasses and cereals inc. wheat , barley ) Oryza sativa rice
3737-694: Is stickier, and is used for sweet dishes, and in Italy for risotto ; and sticky short-grain rice is used in Japanese sushi as it keeps its shape when cooked. White rice when cooked contains 29% carbohydrate and 2% protein, with some manganese . Golden rice is a variety produced by genetic engineering to contain vitamin A . Production of rice is estimated to have caused over 1% of global greenhouse gas emissions in 2022. Predictions of how rice yields will be affected by climate change vary across geographies and socioeconomic contexts. In human culture, rice plays
3838-438: Is subjected to a steaming process before it is milled. This makes the grain harder, and moves some of the grain's vitamins and minerals into the white part of the rice so these are retained after milling. Rice does not contain gluten , so is suitable for people on a gluten-free diet . Rice is a good source of protein and a staple food in many parts of the world, but it is not a complete protein as it does not contain all of
3939-673: Is the application of the principles of engineering and natural sciences to tissues, cells, and molecules. This can be considered as the use of knowledge from working with and manipulating biology to achieve a result that can improve functions in plants and animals. Relatedly, biomedical engineering is an overlapping field that often draws upon and applies biotechnology (by various definitions), especially in certain sub-fields of biomedical or chemical engineering such as tissue engineering , biopharmaceutical engineering , and genetic engineering . Although not normally what first comes to mind, many forms of human-derived agriculture clearly fit
4040-708: Is the directed use of microorganisms for the manufacture of organic products (examples include beer and milk products). Another example is using naturally present bacteria by the mining industry in bioleaching . Biotechnology is also used to recycle, treat waste, clean up sites contaminated by industrial activities ( bioremediation ), and also to produce biological weapons . A series of derived terms have been coined to identify several branches of biotechnology, for example: In medicine, modern biotechnology has many applications in areas such as pharmaceutical drug discoveries and production, pharmacogenomics , and genetic testing (or genetic screening ). In 2021, nearly 40% of
4141-406: Is to flood the field to a depth of 5 cm (2 in), then to let the water level drop to 15 cm (6 in) below surface level, as measured by looking into a perforated field water tube sunk into the soil, and then repeating the cycle. Deepwater rice varieties tolerate flooding to a depth of over 50 centimetres for at least a month. Upland rice is grown without flooding, in hilly or mountainous regions; it
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4242-471: Is used as a model organism in biology. Dry rice grain is milled to remove the outer layers; depending on how much is removed, products range from brown rice to rice with germ and white rice. Some is parboiled to make it easy to cook. Rice contains no gluten ; it provides protein but not all the essential amino acids needed for good health. Rice of different types is eaten around the world. Long-grain rice tends to stay intact on cooking; medium-grain rice
4343-488: Is widely used in biomedical applications, such as the detection of DNA hybridization , biomarker detection from blood , antibody detection, glucose measurement, pH sensing, and genetic technology . By the mid-1980s, other BioFETs had been developed, including the gas sensor FET (GASFET), pressure sensor FET (PRESSFET), chemical field-effect transistor (ChemFET), reference ISFET (REFET), enzyme-modified FET (ENFET) and immunologically modified FET (IMFET). By
4444-634: The DNA of which has been modified with genetic engineering techniques. In most cases, the main aim is to introduce a new trait that does not occur naturally in the species. Biotechnology firms can contribute to future food security by improving the nutrition and viability of urban agriculture. Furthermore, the protection of intellectual property rights encourages private sector investment in agrobiotechnology. Examples in food crops include resistance to certain pests, diseases, stressful environmental conditions, resistance to chemical treatments (e.g. resistance to
4545-470: The Human Genome Project ) has also dramatically improved our understanding of biology and as our scientific knowledge of normal and disease biology has increased, our ability to develop new medicines to treat previously untreatable diseases has increased as well. Genetic testing allows the genetic diagnosis of vulnerabilities to inherited diseases , and can also be used to determine
4646-440: The essential amino acids in sufficient amounts for good health. World trade figures are much smaller than those for production, as less than 8% of rice produced is traded internationally. China, an exporter of rice in the early 2000s, had become the world's largest importer of rice by 2013. Developing countries are the main players in the world rice trade; by 2012, India was the largest exporter of rice, with Thailand and Vietnam
4747-478: The 21st century as people in Asia and elsewhere ate less grain and more meat. An exception is Sub-Saharan Africa, where both per capita consumption of rice and population are increasing. Rice is a commonly-eaten food around the world. The varieties of rice are typically classified as short-, medium-, and long-grained. Oryza sativa indica varieties are usually long-grained; Oryza sativa japonica varieties are usually short- or medium-grained. Short-grain rice, with
4848-704: The Americas by the Spanish. In British North America by the time of the start of the American War of Independence , rice had become the fourth most valuable export commodity behind only tobacco, wheat, and fish. In 2021, world production of rice was 787 million tonnes , led by China and India with a combined 52% of the total. This placed rice fourth in the list of crops by production, after sugarcane , maize , and wheat . Other major producers were Bangladesh , Indonesia and Vietnam . 90% of world production
4949-458: The EU and approval for import and processing. While only a few GMOs have been approved for cultivation in the EU a number of GMOs have been approved for import and processing. The cultivation of GMOs has triggered a debate about the coexistence of GM and non-GM crops. Depending on the coexistence regulations, incentives for the cultivation of GM crops differ. The EUginius (European GMO Initiative for
5050-466: The Philippines have traditionally managed weeds and pests by the polycultural practice of raising ducks and sometimes fish in their rice paddies. These produce valuable additional crops, eat small pest animals, manure the rice, and in the case of ducks also control weeds. Rice plants produce their own chemical defences to protect themselves from pest attacks. Some synthetic chemicals, such as
5151-604: The Quaker Oats Company was purchased by PepsiCo . American Italian Pasta Company bought the Golden Grain brand in 2003, but the sale did not include Rice-a-Roni, which remained with the Quaker Oats division of PepsiCo. Rice-a-Roni is marketing low-sodium versions of its primary products. The company has marketed a line of products with brown rice. In 2024, a third line of products called Mac-A-Roni
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#17327913478455252-518: The antibiotic compound formed by the mold by Howard Florey , Ernst Boris Chain and Norman Heatley – to form what we today know as penicillin . In 1940, penicillin became available for medicinal use to treat bacterial infections in humans. The field of modern biotechnology is generally thought of as having been born in 1971 when Paul Berg's (Stanford) experiments in gene splicing had early success. Herbert W. Boyer (Univ. Calif. at San Francisco) and Stanley N. Cohen (Stanford) significantly advanced
5353-511: The application of biological organisms, systems, or processes by various industries to learning about the science of life and the improvement of the value of materials and organisms, such as pharmaceuticals, crops, and livestock . As per the European Federation of Biotechnology , biotechnology is the integration of natural science and organisms, cells, parts thereof, and molecular analogues for products and services. Biotechnology
5454-465: The benefits these could bring. In 2022, greenhouse gas emissions from rice cultivation were estimated at 5.7 billion tonnes CO2eq, representing 1.2% of total emissions. Within the agriculture sector, rice produces almost half the greenhouse gas emissions from croplands , some 30% of agricultural methane emissions , and 11% of agricultural nitrous oxide emissions. Methane is released from rice fields subject to long-term flooding, as this inhibits
5555-471: The broad definition of "utilizing a biotechnological system to make products". Indeed, the cultivation of plants may be viewed as the earliest biotechnological enterprise. Agriculture has been theorized to have become the dominant way of producing food since the Neolithic Revolution . Through early biotechnology, the earliest farmers selected and bred the best-suited crops (e.g., those with
5656-509: The course of their PhD thesis work. Nineteen institutions offer NIGMS supported BTPs. Biotechnology training is also offered at the undergraduate level and in community colleges. But see also: Domingo, José L.; Bordonaba, Jordi Giné (2011). "A literature review on the safety assessment of genetically modified plants" (PDF) . Environment International . 37 (4): 734–742. Bibcode : 2011EnInt..37..734D . doi : 10.1016/j.envint.2011.01.003 . PMID 21296423 . Archived (PDF) from
5757-511: The crop would be lost under these conditions. In the Po Valley in Italy, the arborio and carnaroli risotto rice varieties have suffered poor harvests through drought in the 21st century. The Ente Nazionale Risi [ it ] is developing drought-resistant varieties; its nuovo prometeo variety has deep roots that enable it to tolerate drought, but is not suitable for risotto. Rice yield can be reduced by weed growth, and
5858-445: The current decades, significant progress has been done in creating genetically modified organisms (GMOs) that enhance the diversity of applications and economical viability of industrial biotechnology. By using renewable raw materials to produce a variety of chemicals and fuels, industrial biotechnology is actively advancing towards lowering greenhouse gas emissions and moving away from a petrochemical-based economy. Synthetic biology
5959-488: The difference between beneficial biotechnology (e.g., bioremediation is to clean up an oil spill or hazard chemical leak) versus the adverse effects stemming from biotechnological enterprises (e.g., flow of genetic material from transgenic organisms into wild strains) can be seen as applications and implications, respectively. Cleaning up environmental wastes is an example of an application of environmental biotechnology ; whereas loss of biodiversity or loss of containment of
6060-458: The discovery and manufacturing of traditional small molecule pharmaceutical drugs as well as drugs that are the product of biotechnology – biopharmaceutics . Modern biotechnology can be used to manufacture existing medicines relatively easily and cheaply. The first genetically engineered products were medicines designed to treat human diseases. To cite one example, in 1978 Genentech developed synthetic humanized insulin by joining its gene with
6161-402: The early 2000s, BioFETs such as the DNA field-effect transistor (DNAFET), gene-modified FET (GenFET) and cell-potential BioFET (CPFET) had been developed. A factor influencing the biotechnology sector's success is improved intellectual property rights legislation—and enforcement—worldwide, as well as strengthened demand for medical and pharmaceutical products. Rising demand for biofuels
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#17327913478456262-425: The exception of Spanish Bomba, is usually sticky when cooked, and is suitable for puddings. Thai Jasmine rice is aromatic, and unusually for a long-grain rice has some stickiness, with a soft texture. Indian Basmati rice is very long-grained and aromatic. Italian Arborio rice , used for risotto , is of medium length, oval, and quite sticky. Japanese sushi rice is a sticky short-grain variety. Cooked white rice
6363-607: The fact these organisms are subject to intellectual property law. Biotechnology has several applications in the realm of food security. Crops like Golden rice are engineered to have higher nutritional content, and there is potential for food products with longer shelf lives. Though not a form of agricultural biotechnology, vaccines can help prevent diseases found in animal agriculture. Additionally, agricultural biotechnology can expedite breeding processes in order to yield faster results and provide greater quantities of food. Transgenic biofortification in cereals has been considered as
6464-425: The field where they will grow, or seedlings can be grown in a seedbed and transplanted into the field. Direct seeding needs some 60 to 80 kg of grain per hectare, while transplanting needs less, around 40 kg per hectare, but requires far more labour. Most rice in Asia is transplanted by hand. Mechanical transplanting takes less time but requires a carefully-prepared field and seedlings raised on mats or in trays to fit
6565-468: The first biosensor in 1962. Biosensor MOSFETs were later developed, and they have since been widely used to measure physical , chemical , biological and environmental parameters. The first BioFET was the ion-sensitive field-effect transistor (ISFET), invented by Piet Bergveld in 1970. It is a special type of MOSFET, where the metal gate is replaced by an ion -sensitive membrane , electrolyte solution and reference electrode . The ISFET
6666-416: The first forms of biotechnology. These processes also were included in early fermentation of beer . These processes were introduced in early Mesopotamia , Egypt , China and India , and still use the same basic biological methods. In brewing , malted grains (containing enzymes ) convert starch from grains into sugar and then adding specific yeasts to produce beer. In this process, carbohydrates in
6767-511: The grain, and cleaning by winnowing or screening . The rice grain is dried as soon as possible to bring the moisture content down to a level that is safe from mould fungi. Traditional drying relies on the heat of the sun, with the grain spread out on mats or on pavements. The edible rice species are members of the BOP clade within the grass family, the Poaceae . The rice subfamily, Oryzoideae ,
6868-416: The grains broke down into alcohols, such as ethanol. Later, other cultures produced the process of lactic acid fermentation , which produced other preserved foods, such as soy sauce . Fermentation was also used in this time period to produce leavened bread . Although the process of fermentation was not fully understood until Louis Pasteur 's work in 1857, it is still the first use of biotechnology to convert
6969-443: The great diversity and continuous evolution of pests. Resistance genes are being sought from wild species of rice, and genetic engineering techniques are being applied. Biotechnology Biotechnology is a multidisciplinary field that involves the integration of natural sciences and engineering sciences in order to achieve the application of organisms and parts thereof for products and services. The term biotechnology
7070-575: The herbicide 2,4-D , cause the plant to increase the production of certain defensive chemicals and thereby increase the plant's resistance to some types of pests. Conversely, other chemicals, such as the insecticide imidacloprid , appear to induce changes in the gene expression of the rice that make the plant more susceptible to certain pests. Plant breeders have created rice cultivars incorporating resistance to various insect pests . Conventional plant breeding of resistant varieties has been limited by challenges such as rearing insect pests for testing, and
7171-478: The highest yields) to produce enough food to support a growing population. As crops and fields became increasingly large and difficult to maintain, it was discovered that specific organisms and their by-products could effectively fertilize , restore nitrogen , and control pests . Throughout the history of agriculture, farmers have inadvertently altered the genetics of their crops through introducing them to new environments and breeding them with other plants — one of
7272-420: The key techniques used in biotechnology is genetic engineering , which allows scientists to modify the genetic makeup of organisms to achieve desired outcomes. This can involve inserting genes from one organism into another, and consequently, create new traits or modifying existing ones. Other important techniques used in biotechnology include tissue culture, which allows researchers to grow cells and tissues in
7373-511: The lab for research and medical purposes, and fermentation , which is used to produce a wide range of products such as beer, wine, and cheese. The applications of biotechnology are diverse and have led to the development of essential products like life-saving drugs, biofuels , genetically modified crops, and innovative materials. It has also been used to address environmental challenges, such as developing biodegradable plastics and using microorganisms to clean up contaminated sites. Biotechnology
7474-410: The later years of the 20th century decreased rice yield by between 10% and 20% across 200 farms in seven Asian countries. This may have been caused by increased night-time respiration. IRRI has predicted that Asian rice yields will fall by some 20% per 1°C rise in global mean temperature. Further, rice is unable to yield grain if the flowers experience a temperature of 35 °C or more for over one hour, so
7575-417: The machine. Rice does not thrive if continuously submerged. Rice can be grown in different environments, depending upon water availability. The usual arrangement is for lowland fields to be surrounded by bunds and flooded to a depth of a few centimetres until around a week before harvest time; this requires a large amount of water. The "alternate wetting and drying" technique uses less water. One form of this
7676-718: The market, but in 2015 the FDA approved the first GM salmon for commercial production and consumption. There is a scientific consensus that currently available food derived from GM crops poses no greater risk to human health than conventional food, but that each GM food needs to be tested on a case-by-case basis before introduction. Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe. The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation. GM crops also provide
7777-815: The methods of genetic engineering . These techniques have allowed for the introduction of new crop traits as well as a far greater control over a food's genetic structure than previously afforded by methods such as selective breeding and mutation breeding . Commercial sale of genetically modified foods began in 1994, when Calgene first marketed its Flavr Savr delayed ripening tomato. To date most genetic modification of foods have primarily focused on cash crops in high demand by farmers such as soybean , corn , canola , and cotton seed oil . These have been engineered for resistance to pathogens and herbicides and better nutrient profiles. GM livestock have also been experimentally developed; in November 2013 none were available on
7878-542: The new technology in 1972 by transferring genetic material into a bacterium, such that the imported material would be reproduced. The commercial viability of a biotechnology industry was significantly expanded on June 16, 1980, when the United States Supreme Court ruled that a genetically modified microorganism could be patented in the case of Diamond v. Chakrabarty . Indian-born Ananda Chakrabarty , working for General Electric , had modified
7979-404: The original on October 9, 2022. In spite of this, the number of studies specifically focused on safety assessment of GM plants is still limited. However, it is important to remark that for the first time, a certain equilibrium in the number of research groups suggesting, on the basis of their studies, that a number of varieties of GM products (mainly maize and soybeans) are as safe and nutritious as
8080-428: The other largest exporters. As of 2016, the countries that consumed the most rice were China (29% of total), India, and Indonesia. By 2020, Bangladesh had taken third place from Indonesia. On an annual average from 2020-23, China consumed 154 million tonnes of rice, India consumed 109 million tonnes, and Bangladesh and Indonesia consumed about 36 million tonnes each. Across the world, rice consumption per capita fell in
8181-463: The production of a chemical known as 1,4-butanediol , which is used in fiber manufacturing. In order to produce 1,4-butanediol, the authors alter the metabolic regulation of the Escherichia coli by CRISPR to induce point mutation in the glt A gene, knockout of the sad gene, and knock-in six genes ( cat 1, suc D, 4hbd , cat 2, bld , and bdh ). Whereas CRISPRi system used to knockdown
8282-460: The production of crops and livestock to use them for food. In selective breeding, organisms with desirable characteristics are mated to produce offspring with the same characteristics. For example, this technique was used with corn to produce the largest and sweetest crops. In the early twentieth century scientists gained a greater understanding of microbiology and explored ways of manufacturing specific products. In 1917, Chaim Weizmann first used
8383-441: The products). The utilization of biological processes, organisms or systems to produce products that are anticipated to improve human lives is termed biotechnology. By contrast, bioengineering is generally thought of as a related field that more heavily emphasizes higher systems approaches (not necessarily the altering or using of biological materials directly ) for interfacing with and utilizing living things. Bioengineering
8484-422: The purpose of sustainable operations (for the return from bottomless initial investment on R & D) and gaining durable patents rights (for exclusives rights for sales, and prior to this to receive national and international approval from the results on animal experiment and human experiment, especially on the pharmaceutical branch of biotechnology to prevent any undetected side-effects or safety concerns by using
8585-470: The regulation of GMOs between countries, with some of the most marked differences occurring between the US and Europe. Regulation varies in a given country depending on the intended use of the products of the genetic engineering. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety. The European Union differentiates between approval for cultivation within
8686-404: The respective conventional non-GM plant, and those raising still serious concerns, was observed. Moreover, it is worth mentioning that most of the studies demonstrating that GM foods are as nutritional and safe as those obtained by conventional breeding, have been performed by biotechnology companies or associates, which are also responsible of commercializing these GM plants. Anyhow, this represents
8787-1011: The soil from absorbing atmospheric oxygen, resulting in anaerobic fermentation of organic matter in the soil. Emissions can be limited by planting new varieties, not flooding continuously, and removing straw. It is possible to cut methane emissions in rice cultivation by improved water management, combining dry seeding and one drawdown, or executing a sequence of wetting and drying . This results in emission reductions of up to 90% compared to full flooding and even increased yields. Predictions of climate change's effects on rice cultivation vary. Global rice yield has been projected to decrease by around 3.2% with each 1°C increase in global average temperature while another study predicts global rice cultivation will increase initially, plateauing at about 3°C warming (2091–2100 relative to 1850–1900). The impacts of climate change on rice cultivation vary across geographic location and socioeconomic context. For example, rising temperatures and decreasing solar radiation during
8888-534: The three competing genes ( gab D, ybg C, and tes B) that affect the biosynthesis pathway of 1,4-butanediol. Consequently, the yield of 1,4-butanediol significantly increased from 0.9 to 1.8 g/L. Environmental biotechnology includes various disciplines that play an essential role in reducing environmental waste and providing environmentally safe processes, such as biofiltration and biodegradation . The environment can be affected by biotechnologies, both positively and adversely. Vallero and others have argued that
8989-542: The time, testing is used to find changes that are associated with inherited disorders. The results of a genetic test can confirm or rule out a suspected genetic condition or help determine a person's chance of developing or passing on a genetic disorder . As of 2011 several hundred genetic tests were in use. Since genetic testing may open up ethical or psychological problems, genetic testing is often accompanied by genetic counseling . Genetically modified crops ("GM crops", or "biotech crops") are plants used in agriculture ,
9090-570: The total company value of pharmaceutical biotech companies worldwide were active in Oncology with Neurology and Rare Diseases being the other two big applications. Pharmacogenomics (a combination of pharmacology and genomics ) is the technology that analyses how genetic makeup affects an individual's response to drugs. Researchers in the field investigate the influence of genetic variation on drug responses in patients by correlating gene expression or single-nucleotide polymorphisms with
9191-701: The voyage to the rest of the Pacific. It reached Austroasiatic and Kra-Dai -speakers in Mainland Southeast Asia and southern China by 5000 years ago. Rice spread around the rest of the world through cultivation, migration and trade, eventually to the Americas as part of the Columbian exchange after 1492. The now less common Oryza glaberrima (African rice) was independently domesticated in Africa around 3,000 years ago, and introduced to
9292-785: The wet season, while thrips outbreaks are associated with drought. Rice blast , caused by the fungus Magnaporthe grisea , is the most serious disease of growing rice. It and bacterial leaf streak (caused by Xanthomonas oryzae pv. oryzae ) are perennially the two worst rice diseases worldwide; they are both among the ten most important diseases of all crop plants. Other major rice diseases include sheath blight (caused by Rhizoctonia solani ), false smut ( Ustilaginoidea virens ), and bacterial panicle blight ( Burkholderia glumae ). Viral diseases include rice bunchy stunt, rice dwarf, rice tungro , and rice yellow mottle. Crop protection scientists are developing sustainable techniques for managing rice pests. Sustainable pest management
9393-507: The world's crop lands were planted with GM crops in 2010. As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the US, Brazil , Argentina , India , Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain. Genetically modified foods are foods produced from organisms that have had specific changes introduced into their DNA with
9494-539: The year provided that sufficient water is made available. It is normally an annual, but in the tropics it can survive as a perennial , producing a ratoon crop. Like all crops, rice depends for its growth on both biotic and abiotic environmental factors. The principal biotic factors are crop variety, pests , and plant diseases . Abiotic factors include the soil type, whether lowland or upland, amount of rain or irrigation water, temperature, day length , and intensity of sunlight. Rice grains can be planted directly into
9595-736: Was domesticated in Africa about 3,000 years ago. Rice has become commonplace in many cultures worldwide; in 2021, 787 million tons were produced, placing it fourth after sugarcane , maize , and wheat . Only some 8% of rice is traded internationally. China, India, and Indonesia are the largest consumers of rice. A substantial amount of the rice produced in developing nations is lost after harvest through factors such as poor transport and storage. Rice yields can be reduced by pests including insects , rodents , and birds , as well as by weeds , and by diseases such as rice blast . Traditional rice polycultures such as rice-duck farming , and modern integrated pest management seek to control damage from pests in
9696-520: Was first domesticated in China 9,000 years ago, by people of Neolithic cultures in the Upper and Lower Yangtze , associated with Hmong-Mien -speakers and pre-Austronesians , respectively. The functional allele for nonshattering , the critical indicator of domestication in grains, as well as five other single-nucleotide polymorphisms , is identical in both indica and japonica . This implies
9797-451: Was first used by Károly Ereky in 1919 to refer to the production of products from raw materials with the aid of living organisms. The core principle of biotechnology involves harnessing biological systems and organisms, such as bacteria, yeast , and plants, to perform specific tasks or produce valuable substances. Biotechnology had a significant impact on many areas of society, from medicine to agriculture to environmental science . One of
9898-508: Was inspired by the pilaf recipe she received from Armenian immigrant Pailadzo Captanian , to create a dish of rice and macaroni, which she served at a family dinner. In 1958, Vince invented Rice-A-Roni by adding a dry chicken soup mix to rice and macaroni. It was introduced in 1958 in the Northwestern United States and went nationwide three years later. Because of its origins, it was called "The San Francisco Treat!" It
9999-574: Was introduced early into Sino-Tibetan cultures in northern China by around 6000 to 5600 years ago, and to the Korean peninsula and Japan by around 5500 to 3200 years ago. It was also carried into Taiwan by the Dapenkeng culture by 5500 to 4000 years ago, before spreading southwards via the Austronesian migrations to Island Southeast Asia , Madagascar , and Guam , but did not survive
10100-495: Was released in cheddar and white cheddar flavors. Rice Rice is a cereal grain and in its domesticated form is the staple food of over half of the world's population , particularly in Asia and Africa . Rice is the seed of the grass species Oryza sativa (Asian rice)—or, much less commonly, Oryza glaberrima (African rice). Asian rice was domesticated in China some 13,500 to 8,200 years ago; African rice
10201-439: Was stored by rural households. The dry grain is milled to remove the outer layers, namely the husk and bran . These can be removed in a single step, in two steps, or as in commercial milling in a multi-step process of cleaning, dehusking, separation, polishing, grading, and weighing. Brown rice only has the inedible husk removed. Further milling removes bran and the germ to create successively whiter products. Parboiled rice
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