The Wolf Foundation is a private not-for-profit organization in Israel established in 1975 by Ricardo Wolf , a German -born Jewish Cuban inventor and former Cuban ambassador to Israel.
100-462: Ricardo Wolf, the founder of the Wolf Foundation, was a Jewish, German-born Cuban inventor , diplomat , philanthropist and former Cuban ambassador to Israel. For many years, he worked to develop a process for recovering iron from smelting process residue. Ultimately successful, his invention was utilized in steel factories all over the world, bringing him considerable wealth. He established
200-569: A disulfiram -like chemical reaction with alcohol by inhibiting its breakdown by acetaldehyde dehydrogenase , which may result in vomiting, nausea, and shortness of breath. In addition, the efficacy of doxycycline and erythromycin succinate may be reduced by alcohol consumption. Other effects of alcohol on antibiotic activity include altered activity of the liver enzymes that break down the antibiotic compound. The successful outcome of antimicrobial therapy with antibacterial compounds depends on several factors. These include host defense mechanisms ,
300-501: A molecular weight of less than 1000 daltons . Since the first pioneering efforts of Howard Florey and Chain in 1939, the importance of antibiotics, including antibacterials, to medicine has led to intense research into producing antibacterials at large scales. Following screening of antibacterials against a wide range of bacteria , production of the active compounds is carried out using fermentation , usually in strongly aerobic conditions. Antimicrobial resistance (AMR or AR)
400-564: A 1959 Australian decision ("NRDC"), they believe that it is not possible to grasp the invention concept in a single rule. A British court once stated that the technical character test implies a "restatement of the problem in more imprecise terminology." In the United States, all patent applications are considered inventions. The statute explicitly says that the American invention concept includes discoveries (35 USC § 100(a)), contrary to
500-497: A Japanese bacteriologist working with Ehrlich in the quest for a drug to treat syphilis , achieved success with the 606th compound in their series of experiments. In 1910, Ehrlich and Hata announced their discovery, which they called drug "606", at the Congress for Internal Medicine at Wiesbaden . The Hoechst company began to market the compound toward the end of 1910 under the name Salvarsan, now known as arsphenamine . The drug
600-643: A biological cost, thereby reducing fitness of resistant strains, which can limit the spread of antibacterial-resistant bacteria, for example, in the absence of antibacterial compounds. Additional mutations, however, may compensate for this fitness cost and can aid the survival of these bacteria. Paleontological data show that both antibiotics and antibiotic resistance are ancient compounds and mechanisms. Useful antibiotic targets are those for which mutations negatively impact bacterial reproduction or viability. Several molecular mechanisms of antibacterial resistance exist. Intrinsic antibacterial resistance may be part of
700-433: A claimed invention is actually an invention. The rules and requirements for patenting an invention vary by country and the process of obtaining a patent is often expensive. Another meaning of invention is cultural invention , which is an innovative set of useful social behaviours adopted by people and passed on to others. The Institute for Social Inventions collected many such ideas in magazines and books. Invention
800-453: A dissertation, " Contribution à l'étude de la concurrence vitale chez les micro-organismes: antagonisme entre les moisissures et les microbes " (Contribution to the study of vital competition in micro-organisms: antagonism between moulds and microbes), the first known scholarly work to consider the therapeutic capabilities of moulds resulting from their anti-microbial activity. In his thesis, Duchesne proposed that bacteria and moulds engage in
900-466: A million new cases of multidrug-resistant tuberculosis (MDR-TB) are estimated to occur worldwide. For example, NDM-1 is a newly identified enzyme conveying bacterial resistance to a broad range of beta-lactam antibacterials. The United Kingdom's Health Protection Agency has stated that "most isolates with NDM-1 enzyme are resistant to all standard intravenous antibiotics for treatment of severe infections." On 26 May 2016, an E. coli " superbug "
1000-480: A new kind of abstraction by dripping, pouring, splashing and splattering paint onto un-stretched canvas lying on the floor. Inventive tools of the artist's trade also produced advances in creativity. Impressionist painting became possible because of newly invented collapsible, resealable metal paint tubes that facilitated spontaneous painting outdoors. Inventions originally created in the form of artwork can also develop other uses, e.g. Alexander Calder's mobile, which
1100-593: A patent applications made to the US Patent Office for inventions are less likely to succeed where the applicant have a "feminine" name, and additionally women could lose their independent legal patent rights to their husbands once married. See also the gender gap in patents . Antibiotics An antibiotic is a type of antimicrobial substance active against bacteria . It is the most important type of antibacterial agent for fighting bacterial infections , and antibiotic medications are widely used in
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#17327719925981200-517: A patient is infected with a β-lactamase -producing strain of bacteria. Antibiotics are commonly classified based on their mechanism of action , chemical structure , or spectrum of activity. Most target bacterial functions or growth processes. Those that target the bacterial cell wall ( penicillins and cephalosporins ) or the cell membrane ( polymyxins ), or interfere with essential bacterial enzymes ( rifamycins , lipiarmycins , quinolones , and sulfonamides ) have bactericidal activities, killing
1300-460: A perpetual battle for survival. Duchesne observed that E. coli was eliminated by Penicillium glaucum when they were both grown in the same culture. He also observed that when he inoculated laboratory animals with lethal doses of typhoid bacilli together with Penicillium glaucum , the animals did not contract typhoid. Duchesne's army service after getting his degree prevented him from doing any further research. Duchesne died of tuberculosis ,
1400-467: A proprietary interest in the patent over a specific period of time, which can be licensed for financial gain. An inventor creates or discovers an invention. The word inventor comes from the Latin verb invenire , invent- , to find. Although inventing is closely associated with science and engineering, inventors are not necessarily engineers or scientists. Due to advances in artificial intelligence ,
1500-465: A resistance mechanism encoded by a single gene conveys resistance to more than one antibacterial compound. Antibacterial-resistant strains and species, sometimes referred to as "superbugs", now contribute to the emergence of diseases that were, for a while, well controlled. For example, emergent bacterial strains causing tuberculosis that are resistant to previously effective antibacterial treatments pose many therapeutic challenges. Every year, nearly half
1600-537: A wide range of bacteria. Following a 40-year break in discovering classes of antibacterial compounds, four new classes of antibiotics were introduced to clinical use in the late 2000s and early 2010s: cyclic lipopeptides (such as daptomycin ), glycylcyclines (such as tigecycline ), oxazolidinones (such as linezolid ), and lipiarmycins (such as fidaxomicin ). With advances in medicinal chemistry , most modern antibacterials are semisynthetic modifications of various natural compounds. These include, for example,
1700-811: Is a naturally occurring process. AMR is driven largely by the misuse and overuse of antimicrobials. Yet, at the same time, many people around the world do not have access to essential antimicrobials. The emergence of antibiotic-resistant bacteria is a common phenomenon mainly caused by the overuse/misuse. It represents a threat to health globally. Each year, nearly 5 million deaths are associated with AMR globally. Emergence of resistance often reflects evolutionary processes that take place during antibiotic therapy. The antibiotic treatment may select for bacterial strains with physiologically or genetically enhanced capacity to survive high doses of antibiotics. Under certain conditions, it may result in preferential growth of resistant bacteria, while growth of susceptible bacteria
1800-406: Is a unique or novel device , method, composition, idea or process. An invention may be an improvement upon a machine, product, or process for increasing efficiency or lowering cost. It may also be an entirely new concept. If an idea is unique enough either as a stand-alone invention or as a significant improvement over the work of others, it can be patented. A patent, if granted, gives the inventor
1900-477: Is almost always used as a partner drug. Methicillin-resistant Staphylococcus aureus infections may be treated with a combination therapy of fusidic acid and rifampicin. Antibiotics used in combination may also be antagonistic and the combined effects of the two antibiotics may be less than if one of the antibiotics was given as a monotherapy . For example, chloramphenicol and tetracyclines are antagonists to penicillins . However, this can vary depending on
2000-449: Is also an important component of artistic and design creativity . Inventions often extend the boundaries of human knowledge, experience or capability. Inventions are of three kinds: scientific-technological (including medicine), sociopolitical (including economics and law), and humanistic, or cultural. Scientific-technological inventions include railroads, aviation , vaccination , hybridization, antibiotics , astronautics, holography ,
2100-427: Is also an important legal concept and central to patent law systems worldwide. As is often the case for legal concepts, its legal meaning is slightly different from common usage of the word. Additionally, the legal concept of invention is quite different in American and European patent law. In Europe, the first test a patent application must pass is, "Is this an invention?" If it is, subsequent questions are whether it
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#17327719925982200-486: Is also one of the treatment options for some skin conditions including acne and cellulitis . Advantages of topical application include achieving high and sustained concentration of antibiotic at the site of infection; reducing the potential for systemic absorption and toxicity, and total volumes of antibiotic required are reduced, thereby also reducing the risk of antibiotic misuse. Topical antibiotics applied over certain types of surgical wounds have been reported to reduce
2300-399: Is an example of misuse. Many antibiotics are frequently prescribed to treat symptoms or diseases that do not respond to antibiotics or that are likely to resolve without treatment. Also, incorrect or suboptimal antibiotics are prescribed for certain bacterial infections. The overuse of antibiotics, like penicillin and erythromycin, has been associated with emerging antibiotic resistance since
2400-490: Is awarded by the Wolf Foundation. The prize has been awarded annually since 1978. It is awarded in six fields: Agriculture , Chemistry , Mathematics , Medicine , Physics , and an Arts prize that rotates annually between architecture , music , painting and sculpture . In some fields such as physics , the prize is often considered the most prestigious award after the Nobel Prize . Inventor An invention
2500-479: Is considered one of the drivers of antibiotic misuse. Several organizations concerned with antimicrobial resistance are lobbying to eliminate the unnecessary use of antibiotics. The issues of misuse and overuse of antibiotics have been addressed by the formation of the US Interagency Task Force on Antimicrobial Resistance. This task force aims to actively address antimicrobial resistance, and
2600-703: Is coordinated by the US Centers for Disease Control and Prevention , the Food and Drug Administration (FDA), and the National Institutes of Health , as well as other US agencies. A non-governmental organization campaign group is Keep Antibiotics Working . In France, an "Antibiotics are not automatic" government campaign started in 2002 and led to a marked reduction of unnecessary antibiotic prescriptions, especially in children. The emergence of antibiotic resistance has prompted restrictions on their use in
2700-626: Is critically important as it can reduce the cost and toxicity of the antibiotic therapy and also reduce the possibility of the emergence of antimicrobial resistance. To avoid surgery, antibiotics may be given for non-complicated acute appendicitis . Antibiotics may be given as a preventive measure and this is usually limited to at-risk populations such as those with a weakened immune system (particularly in HIV cases to prevent pneumonia ), those taking immunosuppressive drugs , cancer patients, and those having surgery . Their use in surgical procedures
2800-607: Is driven largely by the misuse and overuse of antimicrobials. Yet, at the same time, many people around the world do not have access to essential antimicrobials. The World Health Organization has classified AMR as a widespread "serious threat [that] is no longer a prediction for the future, it is happening right now in every region of the world and has the potential to affect anyone, of any age, in any country". Each year, nearly 5 million deaths are associated with AMR globally. Global deaths attributable to AMR numbered 1.27 million in 2019. The term 'antibiosis', meaning "against life",
2900-489: Is inhibited by the drug. For example, antibacterial selection for strains having previously acquired antibacterial-resistance genes was demonstrated in 1943 by the Luria–Delbrück experiment . Antibiotics such as penicillin and erythromycin, which used to have a high efficacy against many bacterial species and strains, have become less effective, due to the increased resistance of many bacterial strains. Resistance may take
3000-623: Is new and sufficiently inventive. The implication—counter-intuitively—is that a legal invention is not inherently novel. Whether a patent application relates to an invention is governed by Article 52 of the European Patent Convention, that excludes, e.g., discoveries as such and software as such . The EPO Boards of Appeal decided that the technical character of an application is decisive for it to represent an invention, following an age-old Italian and German tradition. British courts do not agree with this interpretation. Following
3100-465: Is now commonly used over babies' cribs. Funds generated from patents on inventions in art, design and architecture can support the realization of the invention or other creative work. Frédéric Auguste Bartholdi 's 1879 design patent on the Statue of Liberty helped fund the famous statue because it covered small replicas, including those sold as souvenirs. The timeline for invention in the arts lists
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3200-494: Is to help prevent infection of incisions . They have an important role in dental antibiotic prophylaxis where their use may prevent bacteremia and consequent infective endocarditis . Antibiotics are also used to prevent infection in cases of neutropenia particularly cancer-related. The use of antibiotics for secondary prevention of coronary heart disease is not supported by current scientific evidence, and may actually increase cardiovascular mortality, all-cause mortality and
3300-551: Is to try not to use them, and the second rule is try not to use too many of them." Inappropriate antibiotic treatment and overuse of antibiotics have contributed to the emergence of antibiotic-resistant bacteria. However, potential harm from antibiotics extends beyond selection of antimicrobial resistance and their overuse is associated with adverse effects for patients themselves, seen most clearly in critically ill patients in Intensive care units . Self-prescribing of antibiotics
3400-406: Is unlikely to interfere with many common antibiotics, there are specific types of antibiotics with which alcohol consumption may cause serious side effects. Therefore, potential risks of side effects and effectiveness depend on the type of antibiotic administered. Antibiotics such as metronidazole , tinidazole , cephamandole , latamoxef , cefoperazone , cefmenoxime , and furazolidone , cause
3500-895: The Baháʼí Faith . Some of these disciplines, genres, and trends may seem to have existed eternally or to have emerged spontaneously of their own accord, but most of them have had inventors. Ideas for an invention may be developed on paper or on a computer, by writing or drawing, by trial and error , by making models, by experimenting , by testing and/or by making the invention in its whole form. Brainstorming also can spark new ideas for an invention. Collaborative creative processes are frequently used by engineers, designers, architects and scientists. Co-inventors are frequently named on patents. In addition, many inventors keep records of their working process – notebooks , photos, etc., including Leonardo da Vinci , Galileo Galilei , Evangelista Torricelli , Thomas Jefferson and Albert Einstein . In
3600-742: The United Nations , the European Union , and the Universal Declaration of Human Rights , as well as movements such as socialism , Zionism , suffragism , feminism , and animal-rights veganism. Humanistic inventions encompass culture in its entirety and are as transformative and important as any in the sciences, although people tend to take them for granted. In the domain of linguistics, for example, many alphabets have been inventions, as are all neologisms ( Shakespeare invented about 1,700 words). Literary inventions include
3700-458: The beta-lactam antibiotics , which include the penicillins (produced by fungi in the genus Penicillium ), the cephalosporins , and the carbapenems . Compounds that are still isolated from living organisms are the aminoglycosides , whereas other antibacterials—for example, the sulfonamides , the quinolones , and the oxazolidinones —are produced solely by chemical synthesis . Many antibacterial compounds are relatively small molecules with
3800-441: The bioenergetic failure of immune cells seen in sepsis . They also alter the microbiome of the gut, lungs, and skin, which may be associated with adverse effects such as Clostridioides difficile associated diarrhoea . Whilst antibiotics can clearly be lifesaving in patients with bacterial infections, their overuse, especially in patients where infections are hard to diagnose, can lead to harm via multiple mechanisms. Before
3900-428: The parachute became more useful once powered flight was a reality. Invention is often a creative process . An open and curious mind allows an inventor to see beyond what is known. Seeing a new possibility, connection or relationship can spark an invention. Inventive thinking frequently involves combining concepts or elements from different realms that would not normally be put together. Sometimes inventors disregard
4000-558: The sulfonamides . In current usage, the term "antibiotic" is applied to any medication that kills bacteria or inhibits their growth, regardless of whether that medication is produced by a microorganism or not. The term "antibiotic" derives from anti + βιωτικός ( biōtikos ), "fit for life, lively", which comes from βίωσις ( biōsis ), "way of life", and that from βίος ( bios ), "life". The term "antibacterial" derives from Greek ἀντί ( anti ), "against" + βακτήριον ( baktērion ), diminutive of βακτηρία ( baktēria ), "staff, cane", because
4100-513: The treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the ones which cause the common cold or influenza . Drugs which inhibit growth of viruses are termed antiviral drugs or antivirals. Antibiotics are also not effective against fungi . Drugs which inhibit growth of fungi are called antifungal drugs . Sometimes,
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4200-479: The "abstract idea" test, which suffers from abstractness itself, but none have succeeded. The last attempt so far was the "machine or transformation" test, but the U.S. Supreme Court decided in 2010 that it is merely an indication at best. In India, invention means a new product or process that involves an inventive step, and capable of being made or used in an industry. Whereas, "new invention" means any invention that has not been anticipated in any prior art or used in
4300-402: The 1950s. Widespread usage of antibiotics in hospitals has also been associated with increases in bacterial strains and species that no longer respond to treatment with the most common antibiotics. Common forms of antibiotic misuse include excessive use of prophylactic antibiotics in travelers and failure of medical professionals to prescribe the correct dosage of antibiotics on the basis of
4400-660: The American Holistic Nurses' Association, the American Medical Association , and the American Public Health Association . Despite pledges by food companies and restaurants to reduce or eliminate meat that comes from animals treated with antibiotics, the purchase of antibiotics for use on farm animals has been increasing every year. There has been extensive use of antibiotics in animal husbandry. In
4500-489: The European invention concept. The European invention concept corresponds to the American "patentable subject matter" concept: the first test a patent application is submitted to. While the statute (35 USC § 101) virtually poses no limits to patenting whatsoever, courts have decided in binding precedents that abstract ideas, natural phenomena and laws of nature are not patentable. Various attempts have been made to substantiate
4600-654: The Foundation are grounded in the "Wolf Foundation Law-1975". State Comptroller of Israel oversees all Foundation’s activities. In accordance with the Law mentioned above, the Minister of Education and Culture acts as Chairman of the Council. The Foundation Trustees, Council and Committee Members, Prize Juries, and Internal Auditor perform their duties on a voluntary basis. The aims of the Wolf Foundation are: The Wolf Prize
4700-863: The Nobel Prize in 2000 and has led to innovative lighting, display screens, wallpaper and much more (see conductive polymer , and organic light-emitting diode or OLED ). Invention is often an exploratory process with an uncertain or unknown outcome. There are failures as well as successes. Inspiration can start the process, but no matter how complete the initial idea, inventions typically must be developed. Inventors may, for example, try to improve something by making it more effective, healthier, faster, more efficient, easier to use, serve more purposes, longer lasting, cheaper, more ecologically friendly, or aesthetically different, lighter weight, more ergonomic , structurally different, with new light or color properties, etc. In economic theory , inventions are one of
4800-713: The UK in 1970 (Swann report 1969), and the European Union has banned the use of antibiotics as growth-promotional agents since 2003. Moreover, several organizations (including the World Health Organization, the National Academy of Sciences , and the U.S. Food and Drug Administration ) have advocated restricting the amount of antibiotic use in food animal production. However, commonly there are delays in regulatory and legislative actions to limit
4900-747: The United States, the question of emergence of antibiotic-resistant bacterial strains due to use of antibiotics in livestock was raised by the US Food and Drug Administration (FDA) in 1977. In March 2012, the United States District Court for the Southern District of New York, ruling in an action brought by the Natural Resources Defense Council and others, ordered the FDA to revoke approvals for
5000-572: The Wolf Foundation in 1975. The Foundation began its activities in 1976, with an initial endowment fund of ten million dollar donated by the Wolf family. The major donors were Ricardo Wolf and his wife Francisca. Annual income from investments is used for prizes, scholarships and Foundation operating expenses. It has a status of a private not-for-profit organization in Israel. It is tax-exempt. The objectives and prize administration details and procedures of
5100-565: The activity of antibacterials depends frequently on its concentration, in vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy. In important infectious diseases, including tuberculosis, combination therapy (i.e.,
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#17327719925985200-438: The administration of a broad-spectrum antibiotic based on the signs and symptoms presented and is initiated pending laboratory results that can take several days. When the responsible pathogenic microorganism is already known or has been identified, definitive therapy can be started. This will usually involve the use of a narrow-spectrum antibiotic. The choice of antibiotic given will also be based on its cost. Identification
5300-485: The antagonism observed between some bacteria, it would offer perhaps the greatest hopes for therapeutics". In 1874, physician Sir William Roberts noted that cultures of the mould Penicillium glaucum that is used in the making of some types of blue cheese did not display bacterial contamination. In 1895 Vincenzo Tiberio , Italian physician, published a paper on the antibacterial power of some extracts of mold. In 1897, doctoral student Ernest Duchesne submitted
5400-829: The atomic bomb, computing, the Internet , and the smartphone. Sociopolitical inventions comprise new laws, institutions, and procedures that change modes of social behavior and establish new forms of human interaction and organization. Examples include the British Parliament , the US Constitution , the Manchester (UK) General Union of Trades, the Boy Scouts, the Red Cross , the Olympic Games ,
5500-423: The bacteria. Protein synthesis inhibitors ( macrolides , lincosamides , and tetracyclines ) are usually bacteriostatic , inhibiting further growth (with the exception of bactericidal aminoglycosides ). Further categorization is based on their target specificity. "Narrow-spectrum" antibiotics target specific types of bacteria, such as gram-negative or gram-positive , whereas broad-spectrum antibiotics affect
5600-437: The blood. Women with menstrual irregularities may be at higher risk of failure and should be advised to use backup contraception during antibiotic treatment and for one week after its completion. If patient-specific risk factors for reduced oral contraceptive efficacy are suspected, backup contraception is recommended. In cases where antibiotics have been suggested to affect the efficiency of birth control pills, such as for
5700-487: The boundaries between distinctly separate territories or fields. Several concepts may be considered when thinking about invention. Play may lead to invention. Childhood curiosity, experimentation, and imagination can develop one's play instinct. Inventors feel the need to play with things that interest them, and to explore, and this internal drive brings about novel creations. Sometimes inventions and ideas may seem to arise spontaneously while daydreaming , especially when
5800-568: The broad-spectrum antibiotic rifampicin , these cases may be due to an increase in the activities of hepatic liver enzymes' causing increased breakdown of the pill's active ingredients. Effects on the intestinal flora , which might result in reduced absorption of estrogens in the colon, have also been suggested, but such suggestions have been inconclusive and controversial. Clinicians have recommended that extra contraceptive measures be applied during therapies using antibiotics that are suspected to interact with oral contraceptives . More studies on
5900-554: The case of polytetrafluoroethylene (Teflon). Insight can also be a vital element of invention. Such inventive insights may begin with questions, doubt or a hunch . It may begin by recognizing that something unusual or accidental may be useful or that it could open a new avenue for exploration. For example, the odd metallic color of plastic made by accidentally adding a thousand times too much catalyst led scientists to explore its metal-like properties, inventing electrically conductive plastic and light emitting plastic—an invention that won
6000-517: The chief examples of " positive externalities ", a beneficial side effect that falls on those outside a transaction or activity. One of the central concepts of economics is that externalities should be internalized—unless some of the benefits of this positive externality can be captured by the parties, the parties are under-rewarded for their inventions, and systematic under-rewarding leads to under-investment in activities that lead to inventions. The patent system captures those positive externalities for
6100-438: The concurrent application of two or more antibiotics) has been used to delay or prevent the emergence of resistance. In acute bacterial infections, antibiotics as part of combination therapy are prescribed for their synergistic effects to improve treatment outcome as the combined effect of both antibiotics is better than their individual effect. Fosfomycin has the highest number of synergistic combinations among antibiotics and
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#17327719925986200-482: The conscious mind turns away from the subject or problem when the inventor's focus is on something else, or while relaxing or sleeping. A novel idea may come in a flash—a Eureka ! moment. For example, after years of working to figure out the general theory of relativity, the solution came to Einstein suddenly in a dream "like a giant die making an indelible impress, a huge map of the universe outlined itself in one clear vision". Inventions can also be accidental, such as in
6300-473: The country or anywhere in the world. Invention has a long and important history in the arts . Inventive thinking has always played a vital role in the creative process . While some inventions in the arts are patentable , others are not because they cannot fulfill the strict requirements governments have established for granting them. (see patent ). Some inventions in art include the: Likewise, Jackson Pollock invented an entirely new form of painting and
6400-497: The early 20th century, treatments for infections were based primarily on medicinal folklore . Mixtures with antimicrobial properties that were used in treatments of infections were described over 2,000 years ago. Many ancient cultures, including the ancient Egyptians and ancient Greeks , used specially selected mold and plant materials to treat infections . Nubian mummies studied in the 1990s were found to contain significant levels of tetracycline . The beer brewed at that time
6500-845: The epic, tragedy , comedy, the novel , the sonnet , the Renaissance , neoclassicism, Romanticism , Symbolism , Aestheticism, Socialist Realism , Surrealism , postmodernism , and (according to Freud) psychoanalysis . Among the inventions of artists and musicians are oil painting, printmaking, photography , cinema , musical tonality, atonality, jazz , rock, opera , and the symphony orchestra. Philosophers have invented logic (several times), dialectics , idealism, materialism, utopia , anarchism , semiotics , phenomenology , behaviorism , positivism , pragmatism , and deconstruction . Religious thinkers are responsible for such inventions as monotheism , pantheism , Methodism , Mormonism , iconoclasm, puritanism , deism , secularism, ecumenism, and
6600-605: The first systemically active antibacterial drug, Prontosil , was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany. However, the effectiveness and easy access to antibiotics have also led to their overuse and some bacteria have evolved resistance to them. Antimicrobial resistance (AMR), a naturally occurring process,
6700-399: The first bacteria to be discovered were rod-shaped. Antibiotics are used to treat or prevent bacterial infections, and sometimes protozoan infections . ( Metronidazole is effective against a number of parasitic diseases ). When an infection is suspected of being responsible for an illness but the responsible pathogen has not been identified, an empiric therapy is adopted. This involves
6800-514: The first synthetic antibacterial organoarsenic compound salvarsan , now called arsphenamine. This heralded the era of antibacterial treatment that was begun with the discovery of a series of arsenic-derived synthetic antibiotics by both Alfred Bertheim and Ehrlich in 1907. Ehrlich and Bertheim had experimented with various chemicals derived from dyes to treat trypanosomiasis in mice and spirochaeta infection in rabbits. While their early compounds were too toxic, Ehrlich and Sahachiro Hata ,
6900-444: The form of biodegradation of pharmaceuticals, such as sulfamethazine-degrading soil bacteria introduced to sulfamethazine through medicated pig feces. The survival of bacteria often results from an inheritable resistance, but the growth of resistance to antibacterials also occurs through horizontal gene transfer . Horizontal transfer is more likely to happen in locations of frequent antibiotic use. Antibacterial resistance may impose
7000-923: The genetic makeup of bacterial strains. For example, an antibiotic target may be absent from the bacterial genome . Acquired resistance results from a mutation in the bacterial chromosome or the acquisition of extra-chromosomal DNA. Antibacterial-producing bacteria have evolved resistance mechanisms that have been shown to be similar to, and may have been transferred to, antibacterial-resistant strains. The spread of antibacterial resistance often occurs through vertical transmission of mutations during growth and by genetic recombination of DNA by horizontal genetic exchange . For instance, antibacterial resistance genes can be exchanged between different bacterial strains or species via plasmids that carry these resistance genes. Plasmids that carry several different resistance genes can confer resistance to multiple antibacterials. Cross-resistance to several antibacterials may also occur when
7100-441: The highest consumption with a rate of 64.4. Burundi had the lowest at 4.4. Amoxicillin and amoxicillin/clavulanic acid were the most frequently consumed. Antibiotics are screened for any negative effects before their approval for clinical use, and are usually considered safe and well tolerated. However, some antibiotics have been associated with a wide extent of adverse side effects ranging from mild to very severe depending on
7200-441: The inventor or other patent owner so that the economy as a whole invests an optimum amount of resources in the invention process. In contrast to invention, innovation is the implementation of a creative idea that specifically leads to greater value or usefulness. That is, while an invention may be useless or have no value yet still be an invention, an innovation must have some sort of value, typically economic. The term invention
7300-401: The late 1880s. Ehrlich noted certain dyes would colour human, animal, or bacterial cells, whereas others did not. He then proposed the idea that it might be possible to create chemicals that would act as a selective drug that would bind to and kill bacteria without harming the human host. After screening hundreds of dyes against various organisms, in 1907, he discovered a medicinally useful drug,
7400-409: The location of infection, and the pharmacokinetic and pharmacodynamic properties of the antibacterial. The bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection. Since
7500-415: The mind is free from its usual concerns. For example, both J. K. Rowling (the creator of Harry Potter ) and Frank Hornby (the inventor of Meccano ) first had their ideas while on train journeys. In contrast, the successful aerospace engineer Max Munk advocated "aimful thinking". To invent is to see anew. Inventors often envision a new idea, seeing it in their mind's eye . New ideas can arise when
7600-402: The most notable artistic inventors. Historically, women in many regions have been unrecognised for their inventive contributions (except Russia and France ), despite being the sole inventor or co-inventor in inventions, including highly notable inventions. Notable examples include Margaret Knight who faced significant challenges in receiving credit for her inventions; Elizabeth Magie who
7700-516: The occurrence of stroke. There are many different routes of administration for antibiotic treatment. Antibiotics are usually taken by mouth . In more severe cases, particularly deep-seated systemic infections , antibiotics can be given intravenously or by injection. Where the site of infection is easily accessed, antibiotics may be given topically in the form of eye drops onto the conjunctiva for conjunctivitis or ear drops for ear infections and acute cases of swimmer's ear . Topical use
7800-707: The patient's weight and history of prior use. Other forms of misuse include failure to take the entire prescribed course of the antibiotic, incorrect dosage and administration, or failure to rest for sufficient recovery. Inappropriate antibiotic treatment, for example, is their prescription to treat viral infections such as the common cold . One study on respiratory tract infections found "physicians were more likely to prescribe antibiotics to patients who appeared to expect them". Multifactorial interventions aimed at both physicians and patients can reduce inappropriate prescription of antibiotics. The lack of rapid point of care diagnostic tests, particularly in resource-limited settings
7900-511: The possibility of tendon damage from the administration of a quinolone antibiotic with a systemic corticosteroid . Some antibiotics may also damage the mitochondrion , a bacteria-derived organelle found in eukaryotic, including human, cells. Mitochondrial damage cause oxidative stress in cells and has been suggested as a mechanism for side effects from fluoroquinolones . They are also known to affect chloroplasts . There are few well-controlled studies on whether antibiotic use increases
8000-447: The possible interactions between antibiotics and birth control pills (oral contraceptives) are required as well as careful assessment of patient-specific risk factors for potential oral contractive pill failure prior to dismissing the need for backup contraception. Interactions between alcohol and certain antibiotics may occur and may cause side effects and decreased effectiveness of antibiotic therapy. While moderate alcohol consumption
8100-445: The process of developing an invention, the initial idea may change. The invention may become simpler, more practical, it may expand, or it may even morph into something totally different. Working on one invention can lead to others too. History shows that turning the concept of an invention into a working device is not always swift or direct. Inventions may also become more useful after time passes and other changes occur. For example,
8200-536: The risk of oral contraceptive failure. The majority of studies indicate antibiotics do not interfere with birth control pills , such as clinical studies that suggest the failure rate of contraceptive pills caused by antibiotics is very low (about 1%). Situations that may increase the risk of oral contraceptive failure include non-compliance (missing taking the pill), vomiting, or diarrhea. Gastrointestinal disorders or interpatient variability in oral contraceptive absorption affecting ethinylestradiol serum levels in
8300-790: The risk of surgical site infections. However, there are certain general causes for concern with topical administration of antibiotics. Some systemic absorption of the antibiotic may occur; the quantity of antibiotic applied is difficult to accurately dose, and there is also the possibility of local hypersensitivity reactions or contact dermatitis occurring. It is recommended to administer antibiotics as soon as possible, especially in life-threatening infections. Many emergency departments stock antibiotics for this purpose. Antibiotic consumption varies widely between countries. The WHO report on surveillance of antibiotic consumption published in 2018 analysed 2015 data from 65 countries. As measured in defined daily doses per 1,000 inhabitants per day. Mongolia had
8400-640: The same effect of killing or preventing the growth of microorganisms, and both are included in antimicrobial chemotherapy . "Antibacterials" include bactericides , bacteriostatics , antibacterial soaps , and chemical disinfectants , whereas antibiotics are an important class of antibacterials used more specifically in medicine and sometimes in livestock feed . Antibiotics have been used since ancient times. Many civilizations used topical application of moldy bread, with many references to its beneficial effects arising from ancient Egypt, Nubia , China , Serbia , Greece, and Rome. The first person to directly document
8500-494: The species composition in the intestinal flora , resulting, for example, in overgrowth of pathogenic bacteria, such as Clostridioides difficile . Taking probiotics during the course of antibiotic treatment can help prevent antibiotic-associated diarrhea. Antibacterials can also affect the vaginal flora , and may lead to overgrowth of yeast species of the genus Candida in the vulvo-vaginal area. Additional side effects can result from interaction with other drugs, such as
8600-402: The species of bacteria. In general, combinations of a bacteriostatic antibiotic and bactericidal antibiotic are antagonistic. In addition to combining one antibiotic with another, antibiotics are sometimes co-administered with resistance-modifying agents. For example, β-lactam antibiotics may be used in combination with β-lactamase inhibitors , such as clavulanic acid or sulbactam , when
8700-506: The term antibiotic —literally "opposing life", from the Greek roots ἀντι anti , "against" and βίος bios , "life"—is broadly used to refer to any substance used against microbes , but in the usual medical usage, antibiotics (such as penicillin ) are those produced naturally (by one microorganism fighting another), whereas non-antibiotic antibacterials (such as sulfonamides and antiseptics ) are fully synthetic . However, both classes have
8800-417: The term "inventor" no longer exclusively applies to an occupation (see human computers ). Some inventions can be patented. The system of patents was established to encourage inventors by granting limited-term, limited monopoly on inventions determined to be sufficiently novel, non-obvious, and useful . A patent legally protects the intellectual property rights of the inventor and legally recognizes that
8900-442: The type of antibiotic used, the microbes targeted, and the individual patient. Side effects may reflect the pharmacological or toxicological properties of the antibiotic or may involve hypersensitivity or allergic reactions. Adverse effects range from fever and nausea to major allergic reactions, including photodermatitis and anaphylaxis . Common side effects of oral antibiotics include diarrhea , resulting from disruption of
9000-493: The use of antibiotics in livestock, which violated FDA regulations. Studies have shown that common misconceptions about the effectiveness and necessity of antibiotics to treat common mild illnesses contribute to their overuse. Other forms of antibiotic-associated harm include anaphylaxis , drug toxicity most notably kidney and liver damage, and super-infections with resistant organisms. Antibiotics are also known to affect mitochondrial function, and this may contribute to
9100-508: The use of antibiotics, attributable partly to resistance against such regulation by industries using or selling antibiotics, and to the time required for research to test causal links between their use and resistance to them. Two federal bills (S.742 and H.R. 2562 ) aimed at phasing out nontherapeutic use of antibiotics in US food animals were proposed, but have not passed. These bills were endorsed by public health and medical organizations, including
9200-445: The use of molds to treat infections was John Parkinson (1567–1650). Antibiotics revolutionized medicine in the 20th century. Synthetic antibiotic chemotherapy as a science and development of antibacterials began in Germany with Paul Ehrlich in the late 1880s. Alexander Fleming (1881–1955) discovered modern day penicillin in 1928, the widespread use of which proved significantly beneficial during wartime. The first sulfonamide and
9300-477: Was conjectured to have been the source. The use of antibiotics in modern medicine began with the discovery of synthetic antibiotics derived from dyes. Various Essential oils have been shown to have anti-microbial properties. Along with this, the plants from which these oils have been derived from can be used as niche anti-microbial agents. Synthetic antibiotic chemotherapy as a science and development of antibacterials began in Germany with Paul Ehrlich in
9400-528: Was developed by a research team led by Gerhard Domagk in 1932 or 1933 at the Bayer Laboratories of the IG Farben conglomerate in Germany, for which Domagk received the 1939 Nobel Prize in Physiology or Medicine. Sulfanilamide, the active drug of Prontosil, was not patentable as it had already been in use in the dye industry for some years. Prontosil had a relatively broad effect against Gram-positive cocci , but not against enterobacteria . Research
9500-431: Was first used in 1942 by Selman Waksman and his collaborators in journal articles to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. This definition excluded substances that kill bacteria but that are not produced by microorganisms (such as gastric juices and hydrogen peroxide ). It also excluded synthetic antibacterial compounds such as
9600-423: Was identified in the United States resistant to colistin , "the last line of defence" antibiotic . In recent years, even anaerobic bacteria, historically considered less concerning in terms of resistance, have demonstrated high rates of antibiotic resistance, particularly Bacteroides , for which resistance rates to penicillin have been reported to exceed 90%. Per The ICU Book , "The first rule of antibiotics
9700-511: Was introduced by the French bacteriologist Jean Paul Vuillemin as a descriptive name of the phenomenon exhibited by these early antibacterial drugs. Antibiosis was first described in 1877 in bacteria when Louis Pasteur and Robert Koch observed that an airborne bacillus could inhibit the growth of Bacillus anthracis . These drugs were later renamed antibiotics by Selman Waksman , an American microbiologist, in 1947. The term antibiotic
9800-484: Was not credited for her invention of the game of Monopoly ; and among other such examples, Chien-Shiung Wu whose male colleagues alone were awarded the Nobel Prize for their joint contributions to physics. Societal prejudice, institutional, educational and often legal patent barriers have both played a role in the gender invention gap. For example, although there could be found female patenters in US patent Office who also are likely to be helpful in their experience, still
9900-434: Was stimulated apace by its success. The discovery and development of this sulfonamide drug opened the era of antibacterials. Observations about the growth of some microorganisms inhibiting the growth of other microorganisms have been reported since the late 19th century. These observations of antibiosis between microorganisms led to the discovery of natural antibacterials. Louis Pasteur observed, "if we could intervene in
10000-458: Was used to treat syphilis in the first half of the 20th century. In 1908, Ehrlich received the Nobel Prize in Physiology or Medicine for his contributions to immunology . Hata was nominated for the Nobel Prize in Chemistry in 1911 and for the Nobel Prize in Physiology or Medicine in 1912 and 1913. The first sulfonamide and the first systemically active antibacterial drug, Prontosil ,
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