24-489: (Redirected from TAT ) [REDACTED] Look up tat or TAT in Wiktionary, the free dictionary. Tat or TAT may refer to: Geography [ edit ] Tát , a Hungarian village Tat Ali , an Ethiopian volcano People [ edit ] Tat, a son and disciple of Hermes Trismegistus Tiffani Amber Thiessen , initials T.A.T. Tat Wood ,
48-484: A British author Arts, entertainment, and media [ edit ] TAT (band) , a punk/rock band from London, England Die Tat , a former magazine Aviation [ edit ] TAT, the IATA Airport code of Poprad-Tatry Airport TAT European Airlines , a former French regional airline Total air temperature , sometimes referred to as Stagnation Temperature Transcontinental Air Transport ,
72-582: A Northwestern Iranian language The Three Affiliated Tribes (TAT), a Northern Plains Native American tribe also known as the Mandan, Hidatsa, and Arikara Nation Science, medicine and psychology [ edit ] Tat (HIV) , Trans-Activator of Transcription, HIV protein Tapas Acupressure Technique , an alternative medicine therapy Targeted alpha-particle therapy , radiation therapy for cancer Thematic apperception test ,
96-569: A branch of Persian language Tat people (Iran) , an Iranian ethnic group from Iran Tati language (Iran) , a Northwestern Iranian language The Three Affiliated Tribes (TAT), a Northern Plains Native American tribe also known as the Mandan, Hidatsa, and Arikara Nation Science, medicine and psychology [ edit ] Tat (HIV) , Trans-Activator of Transcription, HIV protein Tapas Acupressure Technique , an alternative medicine therapy Targeted alpha-particle therapy , radiation therapy for cancer Thematic apperception test ,
120-658: A branch of Persian language Juhuri language , the Jewish Tat language Mountain Tats (Crimea) , a mountain-dwelling subethnos of the Crimean Tatars Tat people (Caucasus) , an Iranian people of Persian origin from the Caucasus Tat language (Caucasus) , a Southwestern Iranian language, a branch of Persian language Tat people (Iran) , an Iranian ethnic group from Iran Tati language (Iran) ,
144-522: A former US airline Enterprises and organizations [ edit ] Takraw Association of Thailand (TAT), a sport governing body of Thailand . Tat Bank , a bank based in Tehran, Iran The Astonishing Tribe (or TAT), the former name of the Swedish company Research In Motion Truckers Against Trafficking (or TAT), a nonprofit organization Ethnology [ edit ] Armeno-Tats ,
168-569: A projective psychological test Thrombin–antithrombin complex , a protein complex Tropine acyltransferase , an enzyme Twin-arginine translocation pathway , cellular protein export pathway Tyrosine aminotransferase , an enzyme encoded by the TAT gene TAT, a codon for the amino acid Tyrosine Transport [ edit ] Talbot railway station , Australia Tattenham Corner railway station (National Rail station code), Surrey, England Other uses [ edit ] Tat, verb for
192-520: A projective psychological test Thrombin–antithrombin complex , a protein complex Tropine acyltransferase , an enzyme Twin-arginine translocation pathway , cellular protein export pathway Tyrosine aminotransferase , an enzyme encoded by the TAT gene TAT, a codon for the amino acid Tyrosine Transport [ edit ] Talbot railway station , Australia Tattenham Corner railway station (National Rail station code), Surrey, England Other uses [ edit ] Tat, verb for
216-451: A punk/rock band from London, England Die Tat , a former magazine Aviation [ edit ] TAT, the IATA Airport code of Poprad-Tatry Airport TAT European Airlines , a former French regional airline Total air temperature , sometimes referred to as Stagnation Temperature Transcontinental Air Transport , a former US airline Enterprises and organizations [ edit ] Takraw Association of Thailand (TAT),
240-518: A sport governing body of Thailand . Tat Bank , a bank based in Tehran, Iran The Astonishing Tribe (or TAT), the former name of the Swedish company Research In Motion Truckers Against Trafficking (or TAT), a nonprofit organization Ethnology [ edit ] Armeno-Tats , a subgroup of Armenians in the South Caucasus that speak the Tat language, a Southwestern Iranian language,
264-409: A subgroup of Armenians in the South Caucasus that speak the Tat language, a Southwestern Iranian language, a branch of Persian language Juhuri language , the Jewish Tat language Mountain Tats (Crimea) , a mountain-dwelling subethnos of the Crimean Tatars Tat people (Caucasus) , an Iranian people of Persian origin from the Caucasus Tat language (Caucasus) , a Southwestern Iranian language,
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#1732772770764288-495: Is an enzyme present in the liver and catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate . In humans, the tyrosine aminotransferase protein is encoded by the TAT gene . A deficiency of the enzyme in humans can result in what is known as type II tyrosinemia , wherein there is an abundance of tyrosine as a result of tyrosine failing to undergo an aminotransferase reaction to form 4-hydroxyphenylpyruvate. Structures of
312-478: Is caused by the deposition of tyrosine crystals in the cornea and results in corneal inflammation. The TAT gene is located on human chromosome 16q22-24 and extends over 10.9 kilobases (kb) containing 12 exons, and its 3.0 kb mRNA codes for a 454-amino acid protein of 50.4 kDa. Twelve different TAT gene mutations have been reported. Molecular graphics images were produced using the UCSF Chimera package from
336-560: Is one active site at three different magnifications: [REDACTED] Tyrosinemia is the most common metabolic disease associated with tyrosine aminotransferase. The disease results from a deficiency in hepatic tyrosine aminotransferase. Tyrosinemia type II (Richner-Hanhart syndrome, RHS) is a disease of autosomal recessive inheritance characterized by keratitis, palmoplantar hyperkeratosis, mental retardation, and elevated blood tyrosine levels. Keratitis in Tyrosinemia type II patients
360-474: The Lys280 residue to reform its imine linkage to the enzyme, forming ENZ-PLP. Tyrosine Aminotransferase as a dimer has two identical active site. Lys280 is attached to PLP, which is held in place via two nonpolar amino acid side chains; phenylalanine and isoleucine (see thumbnail on right). The PLP is also held in place by hydrogen bonding to surrounding molecules mainly by its phosphate group. Shown below
384-482: The PLP-TYR molecule. In a similar mechanism of aspartate transaminase , the lysine that forms the initial imine to PLP later acts as the base that attacks the tyrosine in transimination. The electrons left behind from the loss of the proton move down to form a new double bond to the imine, which in turn pushes the already double bonded electrons through PLP and end up as a lone pair on the positively charged nitrogen in
408-448: The action of making lace, see Tatting Tat, informal for cheap, tasteless, useless goods; trinkets; tatty articles or a tatty condition Tat, short for tattoo Tat Tvam Asi , a Hindu philosophical concept Transatlantic telephone cable Turnaround time See also [ edit ] Tati (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
432-448: The action of making lace, see Tatting Tat, informal for cheap, tasteless, useless goods; trinkets; tatty articles or a tatty condition Tat, short for tattoo Tat Tvam Asi , a Hindu philosophical concept Transatlantic telephone cable Turnaround time See also [ edit ] Tati (disambiguation) Topics referred to by the same term [REDACTED] This disambiguation page lists articles associated with
456-480: The alpha carbon of the imine bonded to Lys280, forming a tetrahedral complex and then kicking off the LYS-ENZ. This process is known as transimination by the act of switching out the imine group bonded to PLP. The newly formed PLP-TYR molecule is then attacked by a base. A possible candidate for the base in the mechanism could be Lys280 that was just pushed off of PLP, which sequesters the newly formed amino group of
480-476: The 💕 [REDACTED] Look up tat or TAT in Wiktionary, the free dictionary. Tat or TAT may refer to: Geography [ edit ] Tát , a Hungarian village Tat Ali , an Ethiopian volcano People [ edit ] Tat, a son and disciple of Hermes Trismegistus Tiffani Amber Thiessen , initials T.A.T. Tat Wood , a British author Arts, entertainment, and media [ edit ] TAT (band) ,
504-432: The six-membered ring of the molecule. Water attacks the alpha carbon of the imine of PLP-TYR and through acyl substitution kicks off the nitrogen of PLP and forming pyridoxamine phosphate (PMP) and 4-hydroxyphenylpyruvate. [REDACTED] PMP is then regenerated into PLP by transferring its amine group to alpha-ketoglutarate, reforming its aldehyde functional group. This is followed by another substitution reaction with
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#1732772770764528-502: The three main molecules involved in chemical reaction catalyzed by the tyrosine aminotransferase enzyme are shown below: the amino acid tyrosine (left), the prosthetic group pyridoxal phosphate (right), and the resulting product 4-hydroxyphenylpyruvate (center). Each side of the dimer protein includes pyridoxal phosphate (PLP) bonded to the Lys280 residue of the tyrosine aminotransferase molecule. The amine group of tyrosine attacks
552-533: The title Tat . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Tat&oldid=1224102644 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Language and nationality disambiguation pages tat From Misplaced Pages,
576-756: The title Tat . If an internal link led you here, you may wish to change the link to point directly to the intended article. Retrieved from " https://en.wikipedia.org/w/index.php?title=Tat&oldid=1224102644 " Categories : Disambiguation pages Place name disambiguation pages Hidden categories: Short description is different from Wikidata All article disambiguation pages All disambiguation pages Language and nationality disambiguation pages Tyrosine aminotransferase 3DYD 6898 234724 ENSG00000198650 ENSMUSG00000001670 P17735 Q8QZR1 NM_000353 NM_146214 NP_000344 NP_666326 Tyrosine aminotransferase (or tyrosine transaminase )
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