183-661: The Heartbreakers , sometimes referred to as Johnny Thunders and the Heartbreakers, were an American punk rock band formed in New York City in 1975. The band spearheaded the first wave of punk rock. Johnny Thunders (vocals/guitar) and Jerry Nolan (drums) gained fame in the pioneering proto-punk band the New York Dolls . By early 1975, the Dolls were disintegrating amid poor record sales and tensions within
366-458: A do it yourself (DIY) spirit are prized in punk rock. UK pub rock from 1972 to 1975 contributed to the emergence of punk rock by developing a network of small venues, such as pubs, where non-mainstream bands could play. Pub rock also introduced the idea of independent record labels , such as Stiff Records , which put out basic, low-cost records. Pub rock bands organized their own small venue tours and put out small pressings of their records. In
549-587: A dopamine dysregulation syndrome which occurs in some patients taking dopaminergic drugs , such as amphetamine or methamphetamine. Methamphetamine addiction is persistent for many individuals, with 61% of individuals treated for addiction relapsing within one year. About half of those with methamphetamine addiction continue with use over a ten-year period, while the other half reduce use starting at about one to four years after initial use. The frequent persistence of addiction suggests that long-lasting changes in gene expression may occur in particular regions of
732-406: A drug test for sports, employment, poisoning diagnostics, and forensics. Chiral techniques may be employed to help distinguish the source of the drug to determine whether it was obtained illicitly or legally via prescription or prodrug. Chiral separation is needed to assess the possible contribution of levomethamphetamine , which is an active ingredients in some OTC nasal decongestants, toward
915-486: A stroke he suffered in hospital, while being treated for meningitis and pneumonia. He had been diagnosed with HIV several years prior to his death. Walter Lure had an unconventional post-Heartbreakers career, working as a stock broker on Wall Street. He remained active in the music world with his Heartbreakers-style band the Waldos, who played regularly in New York City; Lure would also do an international tour once or twice
1098-640: A "dirty bastard", a "dirty fucker", and a "fucking rotter", triggering a media controversy. The episode had a major impact on the history of the scene and the punk term became a household name in 24 hours thanks to the press coverage, and several front covers of newspapers. Two days later, the Sex Pistols, the Clash, the Damned, and the Heartbreakers set out on the Anarchy Tour, a series of gigs throughout
1281-473: A "national scandal". Jamie Reid 's "anarchy flag" poster and his other design work for the Sex Pistols helped establish a distinctive punk visual aesthetic . On December 1, 1976, an incident took place that sealed punk rock's notorious reputation, when the Sex Pistols and several members of the Bromley Contingent , including Siouxsie Sioux and Steven Severin , filled a vacancy for Queen on
1464-610: A "punk mass" for the next couple of years. In the March 1971 issue of Creem, critic Greg Shaw wrote about the Shadows of Knight 's "hard-edge punk sound". In an April 1971 issue of Rolling Stone , he referred to a track by the Guess Who as "good, not too imaginative, punk rock and roll". The same month John Medelsohn described Alice Cooper 's album Love It to Death as "nicely wrought mainstream punk raunch". Dave Marsh used
1647-409: A "style of adornment calculated to disturb and outrage". Among the other facets of the punk rock scene, a punk's hair is an important way of showing their freedom of expression. The typical male punk haircut was originally short and choppy; the mohawk later emerged as a characteristic style. Along with the mohawk, long spikes have been associated with the punk rock genre. Between the late 16th and
1830-546: A 1974 interview for his fanzine Heavy Metal Digest , Danny Sugerman told Iggy Pop "You went on record as saying you never were a punk" and Iggy replied "...well I ain't. I never was a punk." By 1975, punk was being used to describe acts as diverse as the Patti Smith Group , the Bay City Rollers , and Bruce Springsteen . As the scene at New York's CBGB club attracted notice, a name was sought for
2013-445: A 4-CD "Definitive Edition" was released in 2012, which included two remixes of the original LP along with demos and rare tracks. Multiple live recordings have been released as well, from both the early lineup with Hell and the L.A.M.F. lineup. Punk rock Punk rock (also known as simply punk ) is a music genre that emerged in the mid-1970s. Rooted in 1950s rock and roll and 1960s garage rock , punk bands rejected
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#17328016729922196-545: A band who can lay claim to influencing the movement, "the seeds of punk remain blatant in the howling ultimatum Erickson transferred from his previous teen combo to the Elevators" as well as describing other bands in the Houston , Texas psychedelic rock scene as "a prime example of the opaque proto-punk undertow at the heart of the best psychedelia ". Hippie proto-punk David Peel of New York City 's Lower East Side
2379-532: A characteristic sound described by Christgau as a "buzzsaw drone". Some punk rock bands take a surf rock approach with a lighter, twangier guitar tone. Others, such as Robert Quine , lead guitarist of the Voidoids , have employed a wild, " gonzo " attack, a style that stretches back through the Velvet Underground to the 1950s recordings of Ike Turner . Bass guitar lines are often uncomplicated;
2562-507: A common needle . The level of needle sharing among methamphetamine users is similar to that among other drug injection users. The psychological effects of methamphetamine can include euphoria , dysphoria , changes in libido , alertness , apprehension and concentration , decreased sense of fatigue, insomnia or wakefulness , self-confidence , sociability, irritability, restlessness, grandiosity and repetitive and obsessive behaviors. Peculiar to methamphetamine and related stimulants
2745-628: A degree in psychology and a postgraduate qualification in theology, working as a substance use disorder counselor. After being persuaded to attend the Max's Kansas City reunion gig in September 2010, Rath reentered the music world and briefly fronted a new band, the Street Pirates. He died on August 16, 2014, aged 66. L.A.M.F. is now considered one of the most influential albums of the first wave of punk . The album has been remixed multiple times;
2928-618: A distinct musical style. Even where they diverged most clearly, in lyrical approach – the Ramones' apparent guilelessness at one extreme, Hell's conscious craft at the other – there was an abrasive attitude in common. Their shared attributes of minimalism and speed, however, had not yet come to define punk rock. After a brief period unofficially managing the New York Dolls, Briton Malcolm McLaren returned to London in May 1975, inspired by
3111-846: A diverse term. It frequently refers to the exaggeration of the unusual effects with features such as irritability, agitation, hallucinations and paranoia. The cardiovascular effects are typically not noticed in young healthy people. Hypertension and tachycardia are not apparent unless measured. A moderate overdose of methamphetamine may induce symptoms such as: abnormal heart rhythm , confusion, difficult and/or painful urination , high or low blood pressure, high body temperature , over-active and/or over-responsive reflexes , muscle aches , severe agitation , rapid breathing , tremor , urinary hesitancy , and an inability to pass urine . An extremely large overdose may produce symptoms such as adrenergic storm , methamphetamine psychosis , substantially reduced or no urine output , cardiogenic shock , bleeding in
3294-455: A few tracks.) That summer, the three found themselves in New York and decided to play some "farewell" shows – as Lure acknowledged, "we were all strung out, we were all in town, and we all needed money." Minus Nolan, the band booked a series of shows at Max's Kansas City with drummer Ty Styx sitting in. Realizing that the band would not last much longer, Max's booker Peter Crowley arranged for
3477-619: A former member of New York's experimental rock group the Velvet Underground , who inspired many of those involved in the creation of punk rock. The New York Dolls updated 1950s' rock 'n' roll in a fashion that later became known as glam punk . The New York duo Suicide played spare, experimental music with a confrontational stage act inspired by that of the Stooges. In Boston, the Modern Lovers , led by Jonathan Richman , gained attention for their minimalistic style. In 1974, as well,
3660-699: A greater affinity for σ 1 than σ 2 , and inhibits monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Sigma receptor activation by methamphetamine may facilitate its central nervous system stimulant effects and promote neurotoxicity within the brain. Dextromethamphetamine is a stronger psychostimulant , but levomethamphetamine has stronger peripheral effects, a longer half-life, and longer perceived effects among heavy substance users. At high doses, both enantiomers of methamphetamine can induce similar stereotypy and methamphetamine psychosis , but levomethamphetamine has shorter psychodynamic effects. The bioavailability of methamphetamine
3843-525: A movement and cultural fad confined to western world in the 1970’s and 1980’s. The early punk bands emulated the minimal musical arrangements of 1960s garage rock . Typical punk rock instrumentation is stripped down to one or two guitars, bass, drums and vocals. Songs tend to be shorter than those of other rock genres and played at fast tempos. Most early punk rock songs retained a traditional rock 'n' roll verse-chorus form and 4/4 time signature . However, later bands often broke from this format. Punk music
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#17328016729924026-529: A musical and a cultural "Year Zero". As nostalgia was discarded, many in the scene adopted a nihilistic attitude summed up by the Sex Pistols ' slogan "No Future"; in the later words of one observer, amid the unemployment and social unrest in 1977, "punk's nihilistic swagger was the most thrilling thing in England." While "self-imposed alienation " was common among "drunk punks" and "gutter punks", there
4209-618: A permanent replacement on drums. The band again found themselves without a recording contract when Track Records went bankrupt – fortunately, due to a provision Childers had inserted in their contract, they were able to recover the master tapes for L.A.M.F. as well as other live recordings. But without a new recording contract, Thunders decided to attempt a solo career, and the band ultimately broke up in early 1978. Thunders remained in London, playing shows with various musicians, and recording his solo debut So Alone (which featured Lure and Rath on
4392-478: A positive test result. Dietary zinc supplements can mask the presence of methamphetamine and other drugs in urine. Methamphetamine is a chiral compound with two enantiomers, dextromethamphetamine and levomethamphetamine . At room temperature, the free base of methamphetamine is a clear and colorless liquid with an odor characteristic of geranium leaves. It is soluble in diethyl ether and ethanol as well as miscible with chloroform . In contrast,
4575-433: A potential treatment for traumatic brain injury . Methamphetamine was discovered in 1893 and exists as two enantiomers : levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical substance, the racemic free base , which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms, but the hydrochloride salt, commonly called crystal meth,
4758-444: A reputation as a must-see live act, no recording contract was forthcoming, a situation that became increasingly frustrating. Lure wrote that "the kind of deals being offered were laughable, sleazy 50-50 splits that the bands could never, ever hope to profit from." Although the band regularly drew packed crowds at Max's and other venues, by this point Thunders, Nolan, and Lure were heroin addicts (Rath preferred methamphetamine ), so money
4941-584: A requisite item for punk fans. The BBC banned "Oh Bondage Up Yours!" due to its controversial lyrics. In October, the Sex Pistols hit number eight with " Holidays in the Sun ", followed by the release of their first and only "official" album, Never Mind the Bollocks, Here's the Sex Pistols . Inspiring yet another round of controversy, it topped the British charts. In December, one of the first books about punk rock
5124-401: A single, "Little Johnny Jewel". In the words of John Walker, the record was "a turning point for the whole New York scene" if not quite for the punk rock sound itself – Hell's departure had left the band "significantly reduced in fringe aggression". Early in 1976, Hell left the Heartbreakers to form the Voidoids , described as "one of the most harshly uncompromising [punk] bands". That April,
5307-562: A time-limited withdrawal syndrome that occurs within 24 hours of their last dose". Withdrawal symptoms in chronic, high-dose users are frequent, occurring in up to 87.6% of cases, and persist for three to four weeks with a marked "crash" phase occurring during the first week. Methamphetamine withdrawal symptoms can include anxiety, drug craving , dysphoric mood , fatigue , increased appetite , increased movement or decreased movement , lack of motivation , sleeplessness or sleepiness , and vivid or lucid dreams . Methamphetamine that
5490-641: A transcription factor, and G9a , a histone methyltransferase enzyme, both directly oppose the induction of ΔFosB in the nucleus accumbens (i.e., they oppose increases in its expression). Sufficiently overexpressing ΔJunD in the nucleus accumbens with viral vectors can completely block many of the neural and behavioral alterations seen in chronic drug use (i.e., the alterations mediated by ΔFosB). ΔFosB also plays an important role in regulating behavioral responses to natural rewards , such as palatable food, sex, and exercise. Since both natural rewards and addictive drugs induce expression of ΔFosB (i.e., they cause
5673-405: A two-month-long weekend residency at CBGB that significantly raised the club's profile. The Television sets included Richard Hell's "Blank Generation", which became the scene's emblematic anthem. Soon after, Hell left Television and founded a band featuring a more stripped-down sound, the Heartbreakers , with former New York Dolls Johnny Thunders and Jerry Nolan . In August, Television recorded
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5856-527: A vehement, straight-ahead punk rock style with a committed anarchist mission, and played a major role in the emerging anarcho-punk movement. Sham 69, London's Menace, and the Angelic Upstarts from South Shields in the Northeast combined a similarly stripped-down sound with populist lyrics, a style that became known as street punk . These expressly working-class bands contrasted with others in
6039-471: A year. Lure was diagnosed in July 2020 with liver and lung cancer, which spread rapidly, and he died from complications related to the cancer on August 21, 2020, at the age of 71. Billy Rath disappeared from the music scene after leaving the Heartbreakers in the mid-1980s, and he undertook a period of rehabilitation to recover from the effects of sustained abuse of drugs and alcohol. Rath then went on to study for
6222-574: Is " punding ", persistent non-goal-directed repetitive activity. Methamphetamine use also has a high association with anxiety , depression , amphetamine psychosis , suicide , and violent behaviors. Methamphetamine is directly neurotoxic to dopaminergic neurons in both lab animals and humans. Excitotoxicity , oxidative stress , metabolic compromise, UPS dysfunction, protein nitration, endoplasmic reticulum stress , p53 expression and other processes contributed to this neurotoxicity. In line with its dopaminergic neurotoxicity, methamphetamine use
6405-414: Is 67% orally , 79% intranasally , 67 to 90% via inhalation ( smoking ), and 100% intravenously . Following oral administration, methamphetamine is well-absorbed into the bloodstream, with peak plasma methamphetamine concentrations achieved in approximately 3.13–6.3 hours post ingestion. Methamphetamine is also well absorbed following inhalation and following intranasal administration. Because of
6588-399: Is applied to those who adopt its stylistic attributes but do not actually share or understand its underlying values and philosophy. Scholar Daniel S. Traber argues that "attaining authenticity in the punk identity can be difficult"; as the punk scene matured, he observes, eventually "everyone got called a poseur". Cultural scholars and music journalists have often attributed ‘true’ punk rock as
6771-400: Is associated with DAT phosphorylation through a Ca2+/calmodulin-dependent protein kinase (CAMK)-dependent signaling pathway, in turn producing dopamine efflux. TAAR1 has been shown to reduce the firing rate of neurons through direct activation of G protein-coupled inwardly-rectifying potassium channels . TAAR1 activation by methamphetamine in astrocytes appears to negatively modulate
6954-481: Is associated with a higher risk of Parkinson's disease . In addition to its dopaminergic neurotoxicity, a review of evidence in humans indicated that high-dose methamphetamine use can also be neurotoxic to serotonergic neurons. It has been demonstrated that a high core temperature is correlated with an increase in the neurotoxic effects of methamphetamine. Withdrawal of methamphetamine in dependent persons may lead to post-acute withdrawal which persists months beyond
7137-482: Is dangerous. Methamphetamine may decrease the effects of sedatives and depressants and increase the effects of antidepressants and other stimulants as well. Methamphetamine may counteract the effects of antihypertensives and antipsychotics owing to its effects on the cardiovascular system and cognition respectively. The pH of gastrointestinal content and urine affects the absorption and excretion of methamphetamine. Specifically, acidic substances will reduce
7320-579: Is especially useful for treatment of concomitant tachycardia and hypertension induced by methamphetamine. The phenomenon of "unopposed alpha stimulation" has not been reported with the use of beta-blockers for treatment of methamphetamine toxicity. Methamphetamine is metabolized by the liver enzyme CYP2D6 , so CYP2D6 inhibitors will prolong the elimination half-life of methamphetamine. Methamphetamine also interacts with monoamine oxidase inhibitors (MAOIs), since both MAOIs and methamphetamine increase plasma catecholamines; therefore, concurrent use of both
7503-540: Is expected to develop with regular methamphetamine use and, when used recreationally, this tolerance develops rapidly. In dependent users, withdrawal symptoms are positively correlated with the level of drug tolerance. Depression from methamphetamine withdrawal lasts longer and is more severe than that of cocaine withdrawal. According to the current Cochrane review on drug dependence and withdrawal in recreational users of methamphetamine, "when chronic heavy users abruptly discontinue [methamphetamine] use, many report
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7686-464: Is found; the usual effective dose is around 20–25 mg/day. Methamphetamine is sometimes prescribed off label for narcolepsy and idiopathic hypersomnia . In the United States, methamphetamine's levorotary form is available in some over-the-counter (OTC) nasal decongestant products. As methamphetamine is associated with a high potential for misuse, the drug is regulated under
7869-611: Is more due to users' other choices. They suggest the side effect has been exaggerated and stylized to create a stereotype of current users as a deterrence for new ones. Methamphetamine use was found to be related to higher frequencies of unprotected sexual intercourse in both HIV-positive and unknown casual partners, an association more pronounced in HIV-positive participants. These findings suggest that methamphetamine use and engagement in unprotected anal intercourse are co-occurring risk behaviors, behaviors that potentially heighten
8052-481: Is much less the rule. Hardcore drumming tends to be especially fast. Production tends to be minimalistic, with tracks sometimes laid down on home tape recorders or four-track portastudios. Punk rock lyrics are typically blunt and confrontational; compared to the lyrics of other popular music genres, they often focus on social and political issues. Trend-setting songs such as the Clash's " Career Opportunities " and Chelsea 's "Right to Work" deal with unemployment and
8235-418: Is not enough evidence on hemodialysis or peritoneal dialysis in cases of methamphetamine intoxication to determine their usefulness. Forced acid diuresis (e.g., with vitamin C ) will increase methamphetamine excretion but is not recommended as it may increase the risk of aggravating acidosis, or cause seizures or rhabdomyolysis. Hypertension presents a risk for intracranial hemorrhage (i.e., bleeding in
8418-510: Is not reported in these statistics and is difficult to know. Unlike fentanyl which causes respiratory depression, methamphetamine is not a respiratory depressant. Some deaths are as a result of intracranial hemorrhage and some deaths are cardiovascular in nature including flash pulmonary edema and ventricular fibrillation. Acute methamphetamine intoxication is largely managed by treating the symptoms and treatments may initially include administration of activated charcoal and sedation . There
8601-609: Is present in a mother's bloodstream can pass through the placenta to a fetus and be secreted into breast milk . Infants born to methamphetamine-abusing mothers may experience a neonatal withdrawal syndrome, with symptoms involving of abnormal sleep patterns, poor feeding, tremors, and hypertonia . This withdrawal syndrome is relatively mild and only requires medical intervention in approximately 4% of cases. Unlike other drugs, babies with prenatal exposure to methamphetamine do not show immediate signs of withdrawal. Instead, cognitive and behavioral problems start emerging when
8784-493: Is some controversy surrounding the facts of his death as the level of methadone in Thunders' body may not have constituted a fatal dose. Thunders also suffered from various health problems, with his autopsy showing evidence of advanced leukemia . In June 1991, a memorial concert was held for Thunders' family, at which Lure, Jerry Nolan, Coiro, and Joey Pinter played a set of Heartbreakers songs. Jerry Nolan died in 1992 following
8967-527: Is subject to substantial interindividual variability . CYP2D6 , dopamine β-hydroxylase , flavin-containing monooxygenase 3 , butyrate-CoA ligase , and glycine N-acyltransferase are the enzymes known to metabolize methamphetamine or its metabolites in humans. The primary metabolites are amphetamine and 4-hydroxymethamphetamine ; other minor metabolites include: 4-hydroxyamphetamine , 4-hydroxynorephedrine , 4-hydroxyphenylacetone , benzoic acid , hippuric acid , norephedrine , and phenylacetone ,
9150-526: Is typically preceded by convulsions and coma . Use of methamphetamine can result in a stimulant psychosis which may present with a variety of symptoms (e.g., paranoia , hallucinations , delirium , and delusions ). A Cochrane Collaboration review on treatment for amphetamine, dextroamphetamine, and methamphetamine use-induced psychosis states that about 5–15% of users fail to recover completely. The same review asserts that, based upon at least one trial, antipsychotic medications effectively resolve
9333-610: Is widely used. Methamphetamine is rarely prescribed over concerns involving its potential for recreational use as an aphrodisiac and euphoriant , among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy such as Adderall and Vyvanse . Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine. Both racemic methamphetamine and dextromethamphetamine are illicitly trafficked and sold owing to their potential for recreational use. The highest prevalence of illegal methamphetamine use occurs in parts of Asia and Oceania, and in
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#17328016729929516-598: The Los Angeles Times , reviewing the debut album by a hard rock band, Aerosmith , declared that it "achieves all that punk-rock bands strive for but most miss." A March 1973 review of an Iggy and the Stooges show in the Detroit Free Press dismissively referred to Pop as "the apotheosis of Detroit punk music". In May 1973, Billy Altman launched the short-lived punk magazine in Buffalo, NY which
9699-592: The American Dental Association , meth mouth "is probably caused by a combination of drug-induced psychological and physiological changes resulting in xerostomia (dry mouth), extended periods of poor oral hygiene , frequent consumption of high-calorie, carbonated beverages and bruxism (teeth grinding and clenching)". As dry mouth is also a common side effect of other stimulants, which are not known to contribute severe tooth decay, many researchers suggest that methamphetamine-associated tooth decay
9882-528: The CBGB club, also in Lower Manhattan . At its core was Television , described by critic John Walker as "the ultimate garage band with pretensions". Their influences ranged from The Velvet Underground to the staccato guitar work of Dr. Feelgood 's Wilko Johnson . The band's bassist/singer, Richard Hell , created a look with cropped, ragged hair, ripped T-shirts, and black leather jackets credited as
10065-493: The Controlled Substances Act and is listed under Schedule II in the United States. Methamphetamine hydrochloride dispensed in the United States is required to include a boxed warning regarding its potential for recreational misuse and addiction liability. Desoxyn and Desoxyn Gradumet are both pharmaceutical forms of the drug. The latter is no longer produced and is a extended-release form of
10248-538: The Krautrock tradition of groups such as Can . In Japan, the anti-establishment Zunō Keisatsu (Brain Police) mixed garage-psych and folk . The combo regularly faced censorship challenges, their live act at least once including onstage masturbation. A new generation of Australian garage rock bands, inspired mainly by the Stooges and MC5 , was coming closer to the sound that would soon be called "punk": In Brisbane ,
10431-639: The United Nations Convention on Psychotropic Substances treaty. While dextromethamphetamine is a more potent drug, racemic methamphetamine is illicitly produced more often, owing to the relative ease of synthesis and regulatory limits of chemical precursor availability. In low to moderate doses, methamphetamine can elevate mood , increase alertness, concentration and energy in fatigued individuals, reduce appetite, and promote weight loss. At very high doses, it can induce psychosis , breakdown of skeletal muscle , seizures , and bleeding in
10614-520: The chromatin that contribute to the persistent epigenetic changes found in methamphetamine addiction. A 2018 systematic review and network meta-analysis of 50 trials involving 12 different psychosocial interventions for amphetamine, methamphetamine, or cocaine addiction found that combination therapy with both contingency management and community reinforcement approach had the highest efficacy (i.e., abstinence rate) and acceptability (i.e., lowest dropout rate). Other treatment modalities examined in
10797-425: The hippocampus , and the prefrontal cortex . Chronic methamphetamine use caused gene-specific histone acetylations, deacetylations and methylations . Gene-specific DNA methylations in particular regions of the brain were also observed. The various epigenetic alterations caused downregulations or upregulations of specific genes important in addiction. For instance, chronic methamphetamine use caused methylation of
10980-450: The presynaptic neuron , and their subsequent release into the synaptic cleft by the phosphorylated transporters. Other transporters that methamphetamine is known to inhibit are SLC22A3 and SLC22A5 . SLC22A3 is an extraneuronal monoamine transporter that is present in astrocytes, and SLC22A5 is a high-affinity carnitine transporter. Methamphetamine is also an agonist of the alpha-2 adrenergic receptors and sigma receptors with
11163-428: The safety-pin aesthetic —was a major influence on Sex Pistols impresario Malcolm McLaren and, in turn, British punk style. ( John D Morton of Cleveland's Electric Eels may have been the first rock musician to wear a safety-pin-covered jacket.) McLaren's partner, fashion designer Vivienne Westwood , credits Johnny Rotten as the first British punk musician to rip his shirt, and Sex Pistols bassist Sid Vicious as
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#173280167299211346-486: The substituted phenethylamine and substituted amphetamine chemical classes . It is related to the other dimethylphenethylamines as a positional isomer of these compounds, which share the common chemical formula C 10 H 15 N . In the United States, methamphetamine hydrochloride, sold under the brand name Desoxyn , is approved by the FDA for treating ADHD and obesity in both adults and children; however,
11529-592: The 18th centuries, punk was a common, coarse synonym for prostitute; William Shakespeare used it with that meaning in The Merry Wives of Windsor (1602) and Measure for Measure (1603–4). The term eventually came to describe "a young male hustler, a gangster, a hoodlum, or a ruffian". The first known use of the phrase "punk rock" appeared in the Chicago Tribune on March 22, 1970, when Ed Sanders , co-founder of New York's anarcho-prankster band
11712-583: The 1990s with Nirvana , punk rock saw renewed major-label interest and mainstream appeal exemplified by the rise of the California bands Green Day , Social Distortion , Rancid , the Offspring , Bad Religion , and NOFX . The anti-government stance and nihilistic impression of the future provided by capitalism united the punk scene in the 1970’s in the United Kingdom as other bands emerged in
11895-456: The 70’s and 80’s like X-Ray Spex and Steel Pulse. The first wave of punk rock was "aggressively modern" and differed from what came before. According to Ramones drummer Tommy Ramone , "In its initial form, a lot of 1960s stuff was innovative and exciting. Unfortunately, what happens is that people who could not hold a candle to the likes of Hendrix started noodling away. Soon you had endless solos that went nowhere. By 1973, I knew that what
12078-484: The Alex Harvey Band — their influence was enormous. And they try to write that all off and wrap it around Patti Smith. It's so wrong!". In October 1976, the Damned released the first UK punk rock band single, " New Rose ". The Vibrators followed the next month with "We Vibrate". On November 26, 1976, the Sex Pistols' released their debut single " Anarchy in the U.K. ", which succeeded in its goal of becoming
12261-644: The British methadone program. Nolan later acknowledged that "everything we did revolved around drugs." Recording sessions for the new album were derailed by drug use – on the part of band members as well as producer Speedy Keen – leading to innumerable attempts at recording and mixing at different studios. The first release from the sessions was the single "Chinese Rocks" b/w "Born To Lose", released in May 1977, which sold well despite being criticized for its poor sound. Nolan admitted "I think it's okay, but not great," and Lure added "The record wasn't really up to par production wise." Band members continued to attempt to remix
12444-459: The Clash , which was joined by Joe Strummer . On June 4, 1976, the Sex Pistols played Manchester's Lesser Free Trade Hall in what became one of the most influential rock shows ever. Among the approximately forty audience members were the two locals who organised the gig—they had formed Buzzcocks after seeing the Sex Pistols in February. Others in the small crowd went on to form Joy Division ,
12627-581: The Clash's debut had included a cover of the recent Jamaican reggae hit " Police and Thieves ". Other first wave bands such as the Slits and new entrants to the scene like the Ruts and the Police interacted with the reggae and ska subcultures, incorporating their rhythms and production styles. The punk rock phenomenon helped spark a full-fledged ska revival movement known as 2 Tone , centered on bands such as
12810-458: The Dead Boys. They were soon playing regularly at Max's Kansas City and CBGB. At this early stage, the term punk applied to the scene in general, not necessarily a particular stylistic approach as it would later—the early New York punk bands represented a broad variety of influences. Among them, the Ramones, the Heartbreakers, Richard Hell and the Voidoids, and the Dead Boys were establishing
12993-658: The Detroit band Death —made up of three African-American brothers—recorded "scorching blasts of feral ur-punk", but could not arrange a release deal. In Ohio, a small but influential underground rock scene emerged, led by Devo in Akron and Kent and by Cleveland's Electric Eels , Mirrors and Rocket from the Tombs . Bands anticipating the forthcoming movement were appearing as far afield as Düsseldorf , West Germany, where "punk before punk" band Neu! formed in 1971, building on
13176-478: The Electric Lady in New York City. Underground and pub rock scenes became filled with cacophonous sounds, haziness brought by drugs and alcohol, and unassuming fashion. American punk represented a new generation that combined bohemian atmosphere with an aggressive guitar distortion. The Dead Boys' debut LP, Young, Loud and Snotty , was released at the end of August. October saw two more debut albums from
13359-611: The English fanzine Sideburns published a now-famous illustration of three chords, captioned "This is a chord, this is another, this is a third. Now form a band". British punk rejected contemporary mainstream rock, the broader culture it represented, and their musical predecessors: "No Elvis , Beatles or the Rolling Stones in 1977", declared the Clash song "1977". 1976, when the punk revolution began in Britain, became
13542-568: The Exploited ), and anarcho-punk (e.g., Crass ), became some of the predominant modes of punk rock, while bands more similar in form to the first wave (e.g., X , the Adicts ) also flourished. Many musicians who identified with punk or were inspired by it went on to pursue other musical directions, giving rise to movements such as post-punk , new wave , thrash metal , and alternative rock . Following alternative rock's mainstream breakthrough in
13725-878: The FDA advises monitoring the height and weight of growing children and adolescents during treatment. Methamphetamine is a sympathomimetic drug that causes vasoconstriction and tachycardia . Methamphetamine also promotes abnormal extra heart beats and irregular heart rhythms some of which may be life threatening. The effects can also include loss of appetite , hyperactivity, dilated pupils , flushed skin , excessive sweating , increased movement , dry mouth and teeth grinding (potentially leading to condition informally known as meth mouth ), headache, rapid breathing , high body temperature , diarrhea, constipation, blurred vision , dizziness , twitching , numbness , tremors , dry skin, acne , and pale appearance . Long-term meth users may have sores on their skin; these may be caused by scratching due to itchiness or
13908-446: The FDA also indicates that the limited therapeutic usefulness of methamphetamine should be weighed against the inherent risks associated with its use. To avoid toxicity and risk of side effects, FDA guidelines recommend an initial dose of methamphetamine at doses 5–10 mg/day for ADHD in adults and children over six years of age, and may be increased at weekly intervals of 5 mg, up to 25 mg/day, until optimum clinical response
14091-559: The Fall , and – in the 1980s — the Smiths . In July, the Ramones played two London shows that helped spark the nascent UK punk scene. Over the next several months, many new punk rock bands formed, often directly inspired by the Sex Pistols. In London, women were near the center of the scene—among the initial wave of bands were the female-fronted Siouxsie and the Banshees , X-Ray Spex , and
14274-546: The Fugs described his first solo album as "punk rock – redneck sentimentality". In 1969 Sanders recorded a song for an album called "Street Punk" but it was only released in 2008. In the December 1970 issue of Creem , Lester Bangs , mocking more mainstream rock musicians, ironically referred to Iggy Pop as "that Stooge punk". Suicide 's Alan Vega credits this usage with inspiring his duo to bill its gigs as "punk music" or
14457-597: The Heartbreakers on July 4, 1975, at CBGB . The band quickly became one of the most popular and well-known underground bands in New York City, headlining shows at CBGB, Mother's (located across from the Chelsea Hotel ), and Max's Kansas City . In the band's early days, each member took turns on vocals, with Hell bringing in songs (such as " Blank Generation ") originally written for Television, and Thunders contributing new material as well. Lure began singing lead on some songs and co-writing with Nolan. The combination of
14640-532: The Heartbreakers' 1976 and 1977 tours of Britain, Thunders played a central role in popularizing heroin among the punk crowd there, as well.) The Ramones' third album, Rocket to Russia , appeared in November 1977. The Sex Pistols ' live TV skirmish with Bill Grundy on December 1, 1976, was the signal moment in British punk 's transformation into a major media phenomenon, even as some stores refused to stock
14823-569: The Heartbreakers. Their first gig was on May 30 of that year, at the Coventry, a rock club in Queens. ( Tom Petty 's band was also named the Heartbreakers, but they did not begin gigging until 1976.) The trio auditioned several candidates for a second guitarist, and soon added Walter Lure to the lineup. Lure, who had previously played with a glam-punk band called the Demons, played his first show with
15006-523: The Jerks led what became known as no wave . The Misfits formed in nearby New Jersey. Still developing what would become their signature B movie –inspired style, later dubbed horror punk , they made their first appearance at CBGB in April 1977. The American youth were searching for authenticity and newcomers like The Ramone, The Clash and The Stooges. They brought their unique sound to venues like CBGB and
15189-754: The Ramones", when nothing could have been further from the truth. In Perth , the Cheap Nasties formed in August. In September 1976, the Saints became the first punk rock band outside the U.S. to release a recording, the single " (I'm) Stranded ". The band self-financed, packaged, and distributed the single. "(I'm) Stranded" had limited impact at home, but the British music press recognized it as groundbreaking. A second wave of punk rock emerged in 1977. These bands often sounded very different from each other. While punk remained largely an underground phenomenon in
15372-460: The Ramones' debut album was released by Sire Records ; the first single was " Blitzkrieg Bop ", opening with the rallying cry "Hey! Ho! Let's go!" According to a later description, "Like all cultural watersheds, Ramones was embraced by a discerning few and slagged off as a bad joke by the uncomprehending majority." The Cramps , whose core members were from Sacramento, California and Akron, Ohio , had debuted at CBGB in November 1976, opening for
15555-635: The Saints evoked the live sound of the British Pretty Things , who had toured Australia and New Zealand in 1975. The origins of New York's punk rock scene can be traced back to such sources as the late 1960s trash culture and an early 1970s underground rock movement centered on the Mercer Arts Center in Greenwich Village , where the New York Dolls performed. In early 1974, a new scene began to develop around
15738-405: The Sex Pistols as central players in a new youth movement, "hard and tough". As described by critic Jon Savage , the band members "embodied an attitude into which McLaren fed a new set of references: late-sixties radical politics, sexual fetish material, pop history, [...] youth sociology". Bernard Rhodes , an associate of McLaren, similarly aimed to make stars of the band London SS , who became
15921-570: The Specials , the Beat , Madness , and the Selecter . In July, the Sex Pistols' third single, " Pretty Vacant ", reached number six and Australia's the Saints had a top-forty hit with " This Perfect Day ". In September, Generation X and the Clash reached the top forty with, respectively, "Your Generation" and " Complete Control ". X-Ray Spex's " Oh Bondage Up Yours! " did not chart, but it became
16104-454: The T-shirt, motorcycle jacket, and jeans ensemble favored by American greasers of the 1950s associated with the rockabilly scene and by British rockers of the 1960s. In addition to the T-shirt, and leather jackets they wore ripped jeans and boots, typically Doc Martens . The punk look was inspired to shock people. Richard Hell 's more androgynous, ragamuffin look—and reputed invention of
16287-640: The Teenage Wasteland" in his review of the Stooges July 1972 performance at King's Cross Cinema in London for a British magazine called Cream (no relation to the more famous US publication). In the January 1973 Rolling Stone review of Nuggets , Greg Shaw commented "Punk rock is a fascinating genre... Punk rock at its best is the closest we came in the '60s to the original rockabilly spirit of Rock 'n Roll." In February 1973, Terry Atkinson of
16470-793: The UK. Many of the shows were cancelled by venue owners in response to the media outrage following the Grundy interview. A punk subculture began in Australia around the same time, centered around Radio Birdman and the Oxford Tavern in Sydney's Darlinghurst suburb. By 1976, the Saints were hiring Brisbane local halls to use as venues, or playing in "Club 76", their shared house in the inner suburb of Petrie Terrace . The band soon discovered that musicians were exploring similar paths in other parts of
16653-783: The US, in the UK it had become a major sensation. During this period punk music also spread beyond the English speaking world, inspiring local scenes in other countries. The California punk scene was fully developed by early 1977. In Los Angeles, there were: the Weirdos , The Dils , the Zeros , the Bags , Black Randy and the Metrosquad , the Germs , Fear , The Go-Go's , X , the Dickies , and
16836-437: The United States, where racemic methamphetamine and dextromethamphetamine are classified as Schedule II controlled substances. Levomethamphetamine is available as an over-the-counter (OTC) drug for use as an inhaled nasal decongestant in the United States. Internationally, the production, distribution, sale, and possession of methamphetamine is restricted or banned in many countries, owing to its placement in schedule II of
17019-462: The Village Gate shows, the band returned to England to attempt to finalize the album, entitled L.A.M.F. (New York gang slang for "like a motherfucker".) Nolan was most vocal about his dissatisfaction with the recordings, and attempted to remix the album himself – but with no better results. Track Records pressured the band to release the album by October 1977 in order to get it in stores for
17202-404: The Voidoids . Replacing Hell with Rath solidified the Heartbreakers sound, firmly rooted in 1950s rock and rhythm 'n' blues, but with the energy, volume, and attitude of punk. Rath was a better bassist than Hell, meshing with Nolan to form a formidable rhythm section, and was also content with playing a supporting role in the band without seeking the spotlight. Now managed by Leee Black Childers ,
17385-543: The Waldos, as well as occasionally playing with Thunders at New York gigs. The Heartbreakers' final show was on November 30, 1990, at the Marquee in New York City, with Coiro on bass. Although both Thunders and Nolan were in deteriorating health by this point, the show went well. Johnny Thunders died in April 1991. His body was found in a hotel room in New Orleans. While Thunders' death may have been drug-related, there
17568-574: The absorption of methamphetamine and increase urinary excretion, while alkaline substances do the opposite. Owing to the effect pH has on absorption, proton pump inhibitors , which reduce gastric acid , are known to interact with methamphetamine. Methamphetamine has been identified as a potent full agonist of trace amine-associated receptor 1 (TAAR1), a G protein-coupled receptor (GPCR) that regulates brain catecholamine systems. Activation of TAAR1 increases cyclic adenosine monophosphate (cAMP) production and either completely inhibits or reverses
17751-576: The album Radios Appear on its own Trafalgar label. By 1979, the hardcore punk movement was emerging in Southern California . A rivalry developed between adherents of the new sound and the older punk rock crowd. Hardcore, appealing to a younger, more suburban audience, was perceived by some as anti-intellectual, overly violent, and musically limited. In Los Angeles, the opposing factions were often described as "Hollywood punks" and "beach punks", referring to Hollywood's central position in
17934-484: The album at various studios in London throughout the summer of 1977, but the problems persisted. In the studio, the band could not seem to capture the power of their live shows – the recordings sounded muddy and lifeless, especially Nolan's drums. As a live act, at this point the Heartbreakers were second to none – a summer tour of the UK was very successful, with a New Musical Express review describing one gig as "the nearest thing I ever saw to Beatlemania ." In August,
18117-647: The all-female the Slits . There were female bassists Gaye Advert in the Adverts and Shanne Bradley in the Nipple Erectors , while Sex store frontwoman Jordan not only managed Adam and the Ants but also performed screaming vocals on their song "Lou". Other groups included Subway Sect , Alternative TV , Wire , the Stranglers , Eater and Generation X . Farther afield, Sham 69 began practicing in
18300-421: The analysis included monotherapy with contingency management or community reinforcement approach, cognitive behavioral therapy , 12-step programs , non-contingent reward-based therapies, psychodynamic therapy , and other combination therapies involving these. As of December 2019 , there is no effective pharmacotherapy for methamphetamine addiction. A systematic review and meta-analysis from 2019 assessed
18483-535: The band also consciously emphasized their New York street-tough image, abandoning the glam rock look Thunders and Nolan had flaunted in the New York Dolls in favor of short hair and '50s style suits. The first gigs with the new lineup took place on July 23 and 24, 1976 at Max's Kansas City and earned rave reviews. The band continued to gig regularly in New York City throughout the summer and fall, and played several shows in Boston in September. Despite Childers' efforts and
18666-474: The band returned to New York City to play three nights at the Village Gate , their first shows in their hometown in nearly a year. Recalled Lure, "It was probably the best shows we ever played in New York, only because we were so tight from touring for six months." These now-legendary shows – which one observer called some of the best rock shows ever – were eventually released as a live album in 2015. After
18849-460: The band, Thunders, Lure, and Rath recruited the Sex Pistols' Paul Cook to play drums on a fall tour of the UK, but soon asked Nolan to rejoin as a hired musician. Nolan finished the tour, but then left again to start a new band, the Idols. The Heartbreakers did a short European tour in November and December with Terry Chimes on drums, after which Lure and Rath returned to New York to attempt to recruit
19032-495: The band, and Thunders and Nolan quit during a tour of Florida in March 1975. Coincidentally, that same week Richard Hell (vocals/bass) left Television . After returning to New York, Thunders and Nolan invited Hell to join their new band, and Hell agreed. As Hell said, "I was fed up with Television because it was getting so pretentious...so I thought, this is perfect – we'll make a really good rock & roll band that's dealing with interesting subjects." The three dubbed their new band
19215-415: The basis for punk rock visual style. In April 1974, Patti Smith came to CBGB for the first time to see the band perform. A veteran of independent theater and performance poetry, Smith was developing an intellectual, feminist take on rock 'n' roll. On June 5, she recorded the single " Hey Joe "/" Piss Factory ", featuring Television guitarist Tom Verlaine ; released on her own Mer Records label, it heralded
19398-413: The belief that insects are crawling under their skin, and the damage is compounded by poor diet and hygiene. Numerous deaths related to methamphetamine overdoses have been reported. Additionally, "[p]ostmortem examinations of human tissues have linked use of the drug to diseases associated with aging, such as coronary atherosclerosis and pulmonary fibrosis", which may be caused "by a considerable rise in
19581-399: The brain , circulatory collapse , hyperpy rexia (i.e., dangerously high body temperature), pulmonary hypertension , kidney failure , rapid muscle breakdown , serotonin syndrome , and a form of stereotypy ("tweaking"). A methamphetamine overdose will likely also result in mild brain damage owing to dopaminergic and serotonergic neurotoxicity. Death from methamphetamine poisoning
19764-437: The brain . Chronic high-dose use can precipitate unpredictable and rapid mood swings , stimulant psychosis (e.g., paranoia , hallucinations , delirium , and delusions ), and violent behavior . Recreationally, methamphetamine's ability to increase energy has been reported to lift mood and increase sexual desire to such an extent that users are able to engage in sexual activity continuously for several days while binging
19947-442: The brain to produce more of it), chronic acquisition of these rewards can result in a similar pathological state of addiction. ΔFosB is the most significant factor involved in both amphetamine addiction and amphetamine-induced sex addictions , which are compulsive sexual behaviors that result from excessive sexual activity and amphetamine use. These sex addictions (i.e., drug-induced compulsive sexual behaviors) are associated with
20130-558: The brain) and, if severe, is typically treated with intravenous phentolamine or nitroprusside . Blood pressure often drops gradually following sufficient sedation with a benzodiazepine and providing a calming environment. Antipsychotics such as haloperidol are useful in treating agitation and psychosis from methamphetamine overdose. Beta blockers with lipophilic properties and CNS penetration such as metoprolol and labetalol may be useful for treating CNS and cardiovascular toxicity. The mixed alpha- and beta-blocker labetalol
20313-453: The brain, and may contribute importantly to the addiction phenotype. In 2014, a crucial role was found for epigenetic mechanisms in driving lasting changes in gene expression in the brain. A review in 2015 summarized a number of studies involving chronic methamphetamine use in rodents. Epigenetic alterations were observed in the brain reward pathways , including areas like ventral tegmental area , nucleus accumbens , and dorsal striatum ,
20496-399: The children reach school age. A prospective cohort study of 330 children showed that at the age of 3, children with methamphetamine exposure showed increased emotional reactivity, as well as more signs of anxiety and depression; and at the age of 5, children showed higher rates of externalizing disorders and attention deficit hyperactivity disorder (ADHD). Methamphetamine overdose is
20679-511: The conclusion of the tour in order to play more gigs and earn a recording contract. Sold-out gigs at London clubs Dingwalls and the Roxy established the band as one of the top groups in the nascent punk scene, and eventually they signed a contract with Track Records in the spring of 1977, earning a substantial advance and beginning work on their debut album. By this point, the band members' addictions were out of control, despite being enrolled in
20862-414: The corporate nature of mainstream 1970s rock music. They typically produced short, fast-paced songs with hard-edged melodies and singing styles with stripped-down instrumentation. Lyricism in punk typically revolves around anti-establishment and anti-authoritarian themes. Punk embraces a DIY ethic ; many bands self-produce recordings and distribute them through independent labels . The term "punk rock"
21045-435: The developing sound. Club owner Hilly Kristal called the movement "Street rock" ; John Holmstrom credits Aquarian magazine with using punk "to describe what was going on at CBGBs". Holmstrom, Legs McNeil , and Ged Dunn's magazine Punk , which debuted at the end of 1975, was crucial in codifying the term. "It was pretty obvious that the word was getting very popular", Holmstrom later remarked. "We figured we'd take
21228-653: The development of drug addictions, since its overexpression in D1-type medium spiny neurons in the nucleus accumbens is necessary and sufficient for most of the behavioral and neural adaptations that arise from addiction. Once ΔFosB is sufficiently overexpressed, it induces an addictive state that becomes increasingly more severe with further increases in ΔFosB expression. It has been implicated in addictions to alcohol , cannabinoids , cocaine , methylphenidate , nicotine , opioids , phencyclidine , propofol , and substituted amphetamines , among others. ΔJunD ,
21411-409: The dose is excreted in urine as methamphetamine and 10–23% as amphetamine. Following IV doses, about 45% is excreted as methamphetamine and 7% as amphetamine. The elimination half-life of methamphetamine varies with a range of 5–30 hours, but it is on average 9 to 12 hours in most studies. The elimination half-life of methamphetamine does not vary by route of administration , but
21594-790: The drug, flattening the curve of the effect of the drug while extending it. Methamphetamine is often used recreationally for its effects as a potent euphoriant and stimulant as well as aphrodisiac qualities. According to a National Geographic TV documentary on methamphetamine, an entire subculture known as party and play is based around sexual activity and methamphetamine use. Participants in this subculture, which consists almost entirely of homosexual male methamphetamine users, will typically meet up through internet dating sites and have sex. Because of its strong stimulant and aphrodisiac effects and inhibitory effect on ejaculation , with repeated use, these sexual encounters will sometimes occur continuously for several days on end. The crash following
21777-425: The drug. Methamphetamine is known to possess a high addiction liability (i.e., a high likelihood that long-term or high dose use will lead to compulsive drug use) and high dependence liability (i.e., a high likelihood that withdrawal symptoms will occur when methamphetamine use ceases). Discontinuing methamphetamine after heavy use may lead to a post-acute-withdrawal syndrome , which can persist for months beyond
21960-486: The early Who , the British punks also reflected the influence of glam rock and related artists and bands such as David Bowie , Slade , T.Rex , and Roxy Music . However, Sex Pistols frontman Johnny Rotten (real name John Lydon) insisted that the influences of the UK punk scene were not from the US and NY. "I've heard an awful lot of American journalists pretending that the whole punk influence came out of New York." He argued: "T. Rex, David Bowie, Slade, Mott The Hoople ,
22143-527: The early 1970s to refer to mid-1960s garage acts. In the liner notes of the 1972 anthology LP, Nuggets , musician and rock journalist Lenny Kaye , later a member of the Patti Smith Group, used the term "punk rock" to describe the genre of 1960s garage bands and "garage-punk", to describe a song recorded in 1966 by the Shadows of Knight. Nick Kent referred to Iggy Pop as the "Punk Messiah of
22326-443: The early days of punk rock, this DIY ethic stood in marked contrast to what those in the scene regarded as the ostentatious musical effects and technological demands of many mainstream rock bands. Musical virtuosity was often looked on with suspicion. According to Holmstrom, punk rock was "rock and roll by people who didn't have very many skills as musicians but still felt the need to express themselves through music". In December 1976,
22509-483: The early evening Thames Television London television show Today to be interviewed by host Bill Grundy . When Grundy asked Siouxsie how she was doing, she made fun of him saying, "I've always wanted to meet you, Bill". Grundy who was drunk, told her on the air; "we shall meet afterwards then". This instantly generated a reaction from Sex Pistols guitarist Steve Jones who pronounced a series of terms inappropriate for prime-time television. Jones proceeded to call Grundy
22692-732: The efficacy of 17 different pharmacotherapies used in randomized controlled trials (RCTs) for amphetamine and methamphetamine addiction; it found only low-strength evidence that methylphenidate might reduce amphetamine or methamphetamine self-administration. There was low- to moderate-strength evidence of no benefit for most of the other medications used in RCTs, which included antidepressants (bupropion, mirtazapine , sertraline ), antipsychotics ( aripiprazole ), anticonvulsants ( topiramate , baclofen , gabapentin ), naltrexone , varenicline , citicoline , ondansetron , prometa , riluzole , atomoxetine , dextroamphetamine, and modafinil . Tolerance
22875-817: The first to use safety pins, although few of those following punk could afford to buy McLaren and Westwood's designs so famously worn by the Pistols, so they made their own, diversifying the 'look' with various different styles based on these designs. Young women in punk demolished the typical female types in rock of either "coy sex kittens or wronged blues belters" in their fashion. Early female punk musicians displayed styles ranging from Siouxsie Sioux 's bondage gear to Patti Smith 's "straight-from-the-gutter androgyny". The former proved much more influential on female fan styles. Over time, tattoos, piercings , and metal-studded and -spiked accessories became increasingly common elements of punk fashion among both musicians and fans,
23058-408: The formation of ceramides , pro-inflammatory molecules that can foster cell aging and death." Methamphetamine users, particularly heavy users, may lose their teeth abnormally quickly, regardless of the route of administration, from a condition informally known as meth mouth . The condition is generally most severe in users who inject the drug, rather than swallow, smoke, or inhale it. According to
23241-416: The formation of reactive oxygen species. Current models of addiction from chronic drug use involve alterations in gene expression in certain parts of the brain, particularly the nucleus accumbens . The most important transcription factors that produce these alterations are ΔFosB , cAMP response element binding protein ( CREB ), and nuclear factor kappa B ( NFκB ). ΔFosB plays a crucial role in
23424-606: The garage phenomenon gathered momentum around the US. By 1965, the harder-edged sound of British acts, such as the Rolling Stones , the Kinks , and the Who , became increasingly influential with American garage bands. The raw sound of U.S. groups such as the Sonics and the Seeds predicted the style of later acts. In the early 1970s some rock critics used the term "punk rock" to refer to
23607-834: The genre that became known as punk was developing, prominent acts included Television , Patti Smith , and the Ramones in New York City; the Saints in Brisbane ; the Sex Pistols , the Clash , and the Damned in London, and the Buzzcocks in Manchester. By late 1976, punk had become a major cultural phenomenon in the UK. It gave rise to a punk subculture that expressed youthful rebellion through distinctive styles of clothing , such as T-shirts with deliberately offensive graphics, leather jackets, studded or spiked bands and jewelry, safety pins, and bondage and S&M clothes. In 1977,
23790-628: The gigs were purely "rent parties" to help the members stay afloat financially (and pay for their addictions.) In 1984, the band was able to rerelease a remixed version of L.A.M.F., and did a reunion tour of Europe in 1984 that led to a live video and album recorded at The Lyceum Ballroom London on March 25, 1984. Billy Rath left the band and the music business after the reunion tour, and was replaced by Tony Coiro. Thunders and Nolan continued their careers solo and (in Nolan's case) with other bands; they toured together in 1986 and 1987. Lure formed his own band,
23973-574: The grim realities of urban life. Especially in early British punk, a central goal was to outrage and shock the mainstream. The Sex Pistols' " Anarchy in the U.K. " and " God Save the Queen " openly disparaged the British political system and social mores. Anti-sentimental depictions of relationships and sex are common, as in "Love Comes in Spurts", recorded by the Voidoids . Anomie , variously expressed in
24156-427: The high lipophilicity of methamphetamine due to its methyl group, it can readily move through the blood–brain barrier faster than other stimulants, where it is more resistant to degradation by monoamine oxidase . The amphetamine metabolite peaks at 10–24 hours. Methamphetamine is excreted by the kidneys, with the rate of excretion into the urine heavily influenced by urinary pH. When taken orally, 30–54% of
24339-405: The holiday season; Nolan threatened to quit if the album was released as is, and when the other three members agreed to Track's demands, Nolan followed through and left the band. Upon its release, the album received excellent reviews, but still drew criticism for its poor sound – especially compared to the Clash and the Sex Pistols albums released the same year. Much of the blame went to Keen, who
24522-445: The influence of the music and subculture spread worldwide. It took root in a wide range of local scenes that often rejected affiliation with the mainstream. In the late 1970s, punk experienced a second wave, when new acts that had not been active during its formative years adopted the style. By the early 1980s, faster and more aggressive subgenres, such as hardcore punk (e.g., Minor Threat ), Oi! (e.g., Sham 69 ), street punk (e.g.,
24705-523: The job. Adopting a new name, the group played its first gig as the Sex Pistols on November 6, 1975, at Saint Martin's School of Art , and soon attracted a small but dedicated following. In February 1976, the band received its first significant press coverage; guitarist Steve Jones declared that the Sex Pistols were not so much into music as they were "chaos". The band often provoked its crowds into near-riots. Rotten announced to one audience, "Bet you don't hate us as much as we hate you!" McLaren envisioned
24888-467: The kind of "cerebral mix of musical ferocity and rebellious posture" that would characterize much of the later British punk rock of the 1970s. The garage/beat phenomenon extended beyond North America and Britain. In America, the psychedelic rock movement birthed an array of garage bands that would later become influences on punk, the Austin Chronicle described the 13th Floor Elevators as
25071-860: The level of biomarkers of metabolic integrity and synthesis occur in recreational users, such as a reduction in N -acetylaspartate and creatine levels and elevated levels of choline and myoinositol . Methamphetamine has been shown to activate TAAR1 in human astrocytes and generate cAMP as a result. Activation of astrocyte-localized TAAR1 appears to function as a mechanism by which methamphetamine attenuates membrane-bound EAAT2 (SLC1A2) levels and function in these cells. Methamphetamine binds to and activates both sigma receptor subtypes, σ 1 and σ 2 , with micromolar affinity. Sigma receptor activation may promote methamphetamine-induced neurotoxicity by facilitating hyperthermia , increasing dopamine synthesis and release, influencing microglial activation, and modulating apoptotic signaling cascades and
25254-641: The lysine in position 4 of histone 3 located at the promoters of the c-fos and the C-C chemokine receptor 2 (ccr2) genes, activating those genes in the nucleus accumbens (NAc). c-fos is well known to be important in addiction . The ccr2 gene is also important in addiction, since mutational inactivation of this gene impairs addiction. In methamphetamine addicted rats, epigenetic regulation through reduced acetylation of histones, in brain striatal neurons, caused reduced transcription of glutamate receptors . Glutamate receptors play an important role in regulating
25437-423: The membrane expression and function of EAAT2 , a type of glutamate transporter . In addition to its effect on the plasma membrane monoamine transporters, methamphetamine inhibits synaptic vesicle function by inhibiting VMAT2 , which prevents monoamine uptake into the vesicles and promotes their release. This results in the outflow of monoamines from synaptic vesicles into the cytosol (intracellular fluid) of
25620-522: The metabolites of amphetamine. Among these metabolites, the active sympathomimetics are amphetamine, 4‑hydroxyamphetamine , 4‑hydroxynorephedrine , 4-hydroxymethamphetamine , and norephedrine. Methamphetamine is a CYP2D6 inhibitor. The main metabolic pathways involve aromatic para-hydroxylation, aliphatic alpha- and beta-hydroxylation, N-oxidation, N-dealkylation, and deamination. The known metabolic pathways include: Methamphetamine and amphetamine are often measured in urine or blood as part of
25803-460: The methamphetamine hydrochloride salt is odorless with a bitter taste. It has a melting point between 170 and 175 °C (338 and 347 °F) and, at room temperature, occurs as white crystals or a white crystalline powder. The hydrochloride salt is also freely soluble in ethanol and water. The crystal structure of either enantiomer is monoclinic with P2 1 space group ; at 90 K (−183.2 °C; −297.7 °F), it has lattice parameters
25986-493: The mid-1960s garage genre, as well as for subsequent acts perceived to be in that stylistic tradition, such as the Stooges. In Britain, largely under the influence of the mod movement and beat groups, the Kinks' 1964 hit singles " You Really Got Me " and " All Day and All of the Night ", were both influenced by "Louie, Louie". In 1965, the Who released the mod anthem " My Generation ", which according to John Reed, anticipated
26169-584: The movement: the Vibrators , formed as a pub rock–style act in February 1976, soon adopted a punk look and sound. A few even longer-active bands including Surrey neo-mods the Jam and pub rockers Eddie and the Hot Rods , the Stranglers , and Cock Sparrer also became associated with the punk rock scene. Alongside the musical roots shared with their American counterparts and the calculated confrontationalism of
26352-532: The name before anyone else claimed it. We wanted to get rid of the bullshit, strip it down to rock 'n' roll. We wanted the fun and liveliness back." The early to mid-1960s garage rock bands in the United States and elsewhere are often recognized as punk rock's progenitors. the Kingsmen 's " Louie, Louie " is often cited as punk rock's defining " ur-text ". After the success of the British Invasion ,
26535-454: The new scene he had witnessed at CBGB. The King's Road clothing store he co-owned, recently renamed Sex , was building a reputation with its outrageous "anti-fashion". Among those who frequented the shop were members of a band called the Strand, which McLaren had also been managing. In August, the group was seeking a new lead singer. Another Sex habitué, Johnny Rotten , auditioned for and won
26718-493: The original L.A. punk rock scene and to hardcore's popularity in the shoreline communities of South Bay and Orange County . Methamphetamine Methamphetamine (contracted from N -methylamphetamine ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational or performance-enhancing drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder (ADHD) and obesity . It has also been researched as
26901-431: The past or are currently taking monoamine oxidase inhibitors should not take methamphetamine. The FDA also advises individuals with bipolar disorder , depression , elevated blood pressure , liver or kidney problems, mania , psychosis , Raynaud's phenomenon , seizures , thyroid problems, tics , or Tourette syndrome to monitor their symptoms while taking methamphetamine. Owing to the potential for stunted growth,
27084-490: The poetic terms of Richard Hell's " Blank Generation " and the bluntness of the Ramones' " Now I Wanna Sniff Some Glue ", is a common theme. The controversial content of punk lyrics has frequently led to certain punk records being banned by radio stations and refused shelf space in major chain stores. Christgau said that "Punk is so tied up with the disillusions of growing up that punks do often age poorly." The classic punk rock look among male American musicians harkens back to
27267-513: The political idealism and Californian flower-power silliness of hippie myth." Hippies were rainbow extremists; punks are romantics of black-and-white. Hippies forced warmth; punks cultivate cool . Hippies kidded themselves about free love ; punks pretend that s&m is our condition. As symbols of protest, swastikas are no less fatuous than flowers. — Robert Christgau in Christgau's Record Guide (1981) Technical accessibility and
27450-476: The quintessential approach is a relentless, repetitive "forced rhythm", although some punk rock bass players—such as Mike Watt of the Minutemen and Firehose —emphasize more technical bass lines. Bassists often use a pick due to the rapid succession of notes, making fingerpicking impractical. Drums typically sound heavy and dry, and often have a minimal set-up. Compared to other forms of rock, syncopation
27633-525: The records and radio airplay was hard to come by. Press coverage of punk misbehavior grew intense: On January 4, 1977, The Evening News of London ran a front-page story on how the Sex Pistols "vomited and spat their way to an Amsterdam flight". In February 1977, the first album by a British punk band appeared: Damned Damned Damned (by the Damned) reached number thirty-six on the UK chart. The EP Spiral Scratch , self-released by Manchester's Buzzcocks ,
27816-411: The reinforcing effects of addictive drugs. Administration of methamphetamine to rodents causes DNA damage in their brain, particularly in the nucleus accumbens region. During repair of such DNA damages, persistent chromatin alterations may occur such as in the methylation of DNA or the acetylation or methylation of histones at the sites of repair. These alterations can be epigenetic scars in
27999-787: The relocated Tupperwares, now dubbed the Screamers . Black Flag formed in Hermosa Beach in 1976 under the name Panic. They developed a hardcore punk sound and played their debut public performance in a garage in Redondo Beach in December 1977. San Francisco's second wave included the Avengers , The Nuns , Negative Trend , the Mutants , and the Sleepers. By mid-1977 in downtown New York, bands such as Teenage Jesus and
28182-450: The risk of HIV transmission among gay and bisexual men. Methamphetamine use allows users of both sexes to engage in prolonged sexual activity, which may cause genital sores and abrasions as well as priapism in men. Methamphetamine may also cause sores and abrasions in the mouth via bruxism , increasing the risk of sexually transmitted infection. Besides the sexual transmission of HIV, it may also be transmitted between users who share
28365-541: The scene's DIY ethic and has often been cited as the first punk rock record. By August, Smith and Television were gigging together at Max's Kansas City . In Forest Hills, Queens , the Ramones drew on sources ranging from the Stooges to the Beatles and the Beach Boys to Herman's Hermits and 1960s girl groups, and condensed rock 'n' roll to its primal level: " '1–2–3–4!' bass-player Dee Dee Ramone shouted at
28548-409: The scene: Richard Hell and the Voidoids' first full-length, Blank Generation , and the Heartbreakers' L.A.M.F. One track on the latter exemplified both the scene's close-knit character and the popularity of heroin within it: " Chinese Rocks " — the title refers to a strong form of the drug – was written by Dee Dee Ramone and Hell, both users, as were the Heartbreakers' Thunders and Nolan. (During
28731-471: The second wave that presaged the post-punk phenomenon. Liverpool's first punk group, Big in Japan , moved in a glam, theatrical direction. The band did not survive long, but it spun off several well-known post-punk acts. The songs of London's Wire were characterized by sophisticated lyrics, minimalist arrangements, and extreme brevity. Alongside thirteen original songs that would define classic punk rock,
28914-449: The shows on September 16, 1978, to be recorded for a live album, The eventual release, Live at Max's Kansas City '79 , would become an immediate classic, capturing the band's live energy as L.A.M.F. had conspicuously failed to do. Nolan eventually rejoined the band in March 1979, and the reunited quartet continued to play regularly in New York throughout 1979 and 1980. But there was no attempt to write new songs or record new material –
29097-426: The shows on the tour being canceled. As Childers said, "The Heartbreakers blew everyone away, for no more reason than they were just more experienced – they had their roots in rhythm and blues and rock 'n' roll...no matter how anarchic an audience thinks it is, if the bass player can actually play, and the drummer is Jerry Nolan, suddenly they're going 'this is GREAT'!" At Childers' behest, the band stayed in London after
29280-461: The songs in the set, with Thunders relegated to one or two songs per set. Thunders walked out, and Nolan and Lure followed; with all three united against him, Hell wound up leaving the band. His final show was on May 14, 1976, at the Rathskeller in Boston. After auditioning several bass players, the band settled on Boston transplant Billy Rath. Hell went on to form his own band, Richard Hell and
29463-411: The southeastern town of Hersham . In Durham , there was Penetration , with lead singer Pauline Murray . On September 20–21, the 100 Club Punk Festival in London featured the Sex Pistols, Clash, Damned, and Buzzcocks, as well as Paris's female-lead Stinky Toys . Siouxsie and the Banshees and Subway Sect debuted on the festival's first night. On the festival's second night, audience member Sid Vicious
29646-429: The start of every song as if the group could barely master the rudiments of rhythm." The band played its first show at CBGB in August 1974. By the end of the year, the Ramones had performed seventy-four shows, each about seventeen minutes long. "When I first saw the Ramones", critic Mary Harron later remembered, "I couldn't believe people were doing this. The dumb brattiness." That spring, Smith and Television shared
29829-447: The style-conscious Nolan and Thunders with the beatnik Hell and gangly Lure made for a visually arresting and musically powerful group. As Blondie's Clem Burke said, "You could call them the punk rock Beatles. Each person really stood out." Although popular, the early lineup could not get a recording contract, in no small part due to the band's well-known heroin use – as vividly described in their best-known song, " Chinese Rocks " (which
30012-471: The symptoms of acute amphetamine psychosis. Amphetamine psychosis may also develop occasionally as a treatment-emergent side effect. The CDC reported that the number of deaths in the United States involving psychostimulants with abuse potential to be 23,837 in 2020 and 32,537 in 2021. This category code (ICD–10 of T43.6) includes primarily methamphetamine but also other stimulants such as amphetamine, and methylphenidate. The mechanism of death in these cases
30195-527: The term in the May 1971 issue of Creem , where he described ? and the Mysterians as giving a "landmark exposition of punk rock". Later in 1971, in his fanzine Who Put the Bomp , Greg Shaw wrote about "what I have chosen to call "punkrock" bands—white teenage hard rock of '64–66 ( Standells , Kingsmen, Shadows of Knight , etc.)". Lester Bangs used the term "punk rock" in several articles written in
30378-460: The transport direction of the dopamine transporter (DAT), norepinephrine transporter (NET), and serotonin transporter (SERT). When methamphetamine binds to TAAR1, it triggers transporter phosphorylation via protein kinase A (PKA) and protein kinase C (PKC) signaling, ultimately resulting in the internalization or reverse function of monoamine transporters . Methamphetamine is also known to increase intracellular calcium, an effect which
30561-423: The typical withdrawal period. At high doses, methamphetamine is neurotoxic to human midbrain dopaminergic neurons and, to a lesser extent, serotonergic neurons. Methamphetamine neurotoxicity causes adverse changes in brain structure and function, such as reductions in grey matter volume in several brain regions, as well as adverse changes in markers of metabolic integrity. Methamphetamine belongs to
30744-538: The typical withdrawal period. Magnetic resonance imaging studies on human methamphetamine users have also found evidence of neurodegeneration, or adverse neuroplastic changes in brain structure and function. In particular, methamphetamine appears to cause hyperintensity and hypertrophy of white matter , marked shrinkage of hippocampi , and reduced gray matter in the cingulate cortex , limbic cortex , and paralimbic cortex in recreational methamphetamine users. Moreover, evidence suggests that adverse changes in
30927-600: The use of methamphetamine in this manner is very often severe, with marked hypersomnia (excessive daytime sleepiness). The party and play subculture is prevalent in major US cities such as San Francisco and New York City. Methamphetamine is contraindicated in individuals with a history of substance use disorder , heart disease , or severe agitation or anxiety, or in individuals currently experiencing arteriosclerosis , glaucoma , hyperthyroidism , or severe hypertension . The FDA states that individuals who have experienced hypersensitivity reactions to other stimulants in
31110-435: The world. Ed Kuepper , co-founder of the Saints, later recalled: One thing I remember having had a really depressing effect on me was the first Ramones album. When I heard it [in 1976], I mean it was a great record [...] but I hated it because I knew we'd been doing this sort of stuff for years. There was even a chord progression on that album that we used [...] and I thought, "Fuck. We're going to be labeled as influenced by
31293-470: Was a benchmark for both the DIY ethic and regionalism in the country's punk movement. The Clash 's self-titled debut album came out two months later and rose to number twelve; the single " White Riot " entered the top forty. In May, the Sex Pistols achieved new heights of controversy (and number two on the singles chart) with " God Save the Queen ". The band had recently acquired a new bassist, Sid Vicious , who
31476-565: Was actually written by Dee Dee Ramone with contributions from Hell). Live recordings of the Thunders/Hell/Nolan/Lure lineup were eventually released on the LP Live at Mother's , and studio demos were released in 2019. Although initially the band members shared songwriting and singing, Hell increasingly attempted to impose his will on the band. At a rehearsal in early 1976, Hell laid down an ultimatum – he would sing most of
31659-424: Was always a tension between their nihilistic outlook and the "radical leftist utopianism" of bands such as Crass , who found positive, liberating meaning in the movement. As a Clash associate describes singer Joe Strummer 's outlook, "Punk rock is meant to be our freedom. We're meant to be able to do what we want to do." Authenticity has always been important in the punk subculture—the pejorative term " poseur "
31842-455: Was arrested for having thrown a glass at the Damned that shattered and destroyed a girl's eye. Press coverage of the incident reinforced punk's reputation as a social menace. Some new bands, such as London's Ultravox !, Edinburgh's Rezillos , Manchester's the Fall, and Leamington 's the Shapes , identified with the scene even as they pursued more experimental music. Others of a comparatively traditional rock 'n' roll bent were also swept up by
32025-414: Was largely devoted to discussion of 1960s garage and psychedelic acts. In May 1974, Los Angeles Times critic Robert Hilburn reviewed the second New York Dolls album, Too Much Too Soon . "I told ya the New York Dolls were the real thing," he wrote, describing the album as "perhaps the best example of raw, thumb-your-nose-at-the-world, punk rock since the Rolling Stones ' Exile on Main Street ." In
32208-441: Was needed was some pure, stripped down, no bullshit rock 'n' roll." John Holmstrom , founding editor of Punk magazine, recalls feeling "punk rock had to come along because the rock scene had become so tame that [acts] like Billy Joel and Simon and Garfunkel were being called rock and roll, when to me and other fans, rock and roll meant this wild and rebellious music." According to Robert Christgau , punk "scornfully rejected
32391-483: Was not a standalone movement in the 70’s and 80’s. Major punk communities gather across the globe as punk perseveres among contemporary musicians and listeners today. The vocals are sometimes nasal, and the lyrics often shouted in an "arrogant snarl", rather than conventionally sung. Complicated guitar solos were considered self-indulgent, although basic guitar breaks were common. Guitar parts tend to include highly distorted power chords or barre chords , creating
32574-408: Was not a trained recording engineer, but problems with the mastering process likely affected the record as well. L.A.M.F. would ultimately be remixed and rereleased multiple times to try to extract the band's raw power from the master tapes. As Childers said, the album's failure to capture the Heartbreakers' live sound was "the biggest, hugest fuck-up in the history of rock 'n' roll." With Nolan out of
32757-444: Was previously used by American rock critics in the early 1970s to describe the mid-1960s garage bands. Certain late 1960s and early 1970s Detroit acts, such as MC5 and Iggy and the Stooges , and other bands from elsewhere created out-of-the-mainstream music that became highly influential on what was to come. Glam rock in the UK and the New York Dolls from New York have also been cited as key influences. Between 1974 and 1976, when
32940-464: Was published: The Boy Looked at Johnny , by Julie Burchill and Tony Parsons . In February 1977, EMI released the Saints ' debut album, (I'm) Stranded , which the band recorded in two days. The Saints had relocated to Sydney; in April, they and Radio Birdman united for a major gig at Paddington Town Hall . Last Words had also formed in the city. The following month, the Saints relocated again, to Great Britain. In June, Radio Birdman released
33123-457: Was seen as exemplifying the punk persona. The swearing during the Grundy interview and the controversy over "God Save the Queen" led to a moral panic . Scores of new punk groups formed around the United Kingdom, as far from London as Belfast 's Stiff Little Fingers and Dunfermline , Scotland's the Skids . Though most survived only briefly, perhaps recording a small-label single or two, others set off new trends. Crass , from Essex , merged
33306-401: Was the first person to use the word " motherfucker " in a song title and also directly influenced the Clash . In August 1969, the Stooges , from Ann Arbor , premiered with a self-titled album . According to critic Greil Marcus , the band, led by singer Iggy Pop , created "the sound of Chuck Berry 's Airmobile —after thieves stripped it for parts". The album was produced by John Cale ,
33489-410: Was tight. The band got what seemed like a break when the Sex Pistols invited the band to open for them on the ill-fated Anarchy Tour (the Sex Pistols at this time were managed by Malcolm McLaren , who had previously managed The New York Dolls). Arriving for the tour just as the UK punk scene was building momentum, the Heartbreakers quickly developed a following in and around London despite most of
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