The Ultra-Trail du Mont-Blanc ( UTMB ) is a mountain ultramarathon race, first held in 2003, that follows the route of the Tour du Mont Blanc . It has been regarded as the most competitive trail ultramarathon in the world.
104-645: Renamed in 2023 as UTMB World Series Finals , it is the final event of the UTMB World Series qualification races held throughout the world. The race takes place once a year on either the last weekend in August or the first weekend of September in the Alps . It follows the route of the Tour du Mont Blanc through France , Italy and Switzerland . It has a distance of approximately 171 kilometres (106 mi), and
208-625: A healthy diet are also recommended. Supportive care in severe cases includes treatment to relieve symptoms , fluid therapy , oxygen support and prone positioning , and medications or devices to support other affected vital organs. More severe cases may need treatment in hospital. In those with low oxygen levels, use of the glucocorticoid dexamethasone is recommended to reduce mortality. Noninvasive ventilation and, ultimately, admission to an intensive care unit for mechanical ventilation may be required to support breathing. Extracorporeal membrane oxygenation (ECMO) has been used to address
312-627: A variant of concern (VoC) or a variant of interest (VoI). Many of these variants have shared the more infectious D614G . As of May 2023, the WHO had downgraded all variants of concern to previously circulating as these were no longer detected in new infections. Sub-lineages of the Omicron variant (BA.1 – BA.5) were considered separate VoCs by the WHO until they were downgraded in March 2023 as no longer widely circulating. As of 24 September 2024 ,
416-493: A comprehensive international study. Such deaths include deaths due to healthcare capacity constraints and priorities, as well as reluctance to seek care (to avoid possible infection). Further research may help distinguish the proportions directly caused by COVID-19 from those caused by indirect consequences of the pandemic. In May 2022, the WHO estimated the number of excess deaths by the end of 2021 to be 14.9 million compared to 5.4 million reported COVID-19 deaths, with
520-611: A crescent shaped geographic feature of central Europe that ranges in an 800 km (500 mi) arc (curved line) from east to west and is 200 km (120 mi) in width. The mean height of the mountain peaks is 2.5 km (1.6 mi). The range stretches from the Mediterranean Sea north above the Po basin, extending through France from Grenoble , and stretching eastward through mid and southern Switzerland. The range continues onward toward Vienna , Austria, and southeast to
624-595: A large number of people". During the COVID-19 pandemic, as with other pandemics, the meaning of this term has been challenged. The end of a pandemic or other epidemic only rarely involves the total disappearance of a disease, and historically, much less attention has been given to defining the ends of epidemics than their beginnings. The ends of particular epidemics have been defined in a variety of ways, differing according to academic field, and differently based on location and social group. An epidemic's end can be considered
728-743: A major commercial and military road between Western Europe and Italy. The pass was crossed by many troops on their way to the Italian peninsula. From Constantine I , Pepin the Short and Charlemagne to Henry IV , Napoléon and more recently the German Gebirgsjägers during World War II . Now the pass has been supplanted by the Fréjus Highway Tunnel (opened 1980) and Rail Tunnel (opened 1871). The Saint Gotthard Pass crosses from Central Switzerland to Ticino ; in 1882
832-708: A man was in 1788; the first ascent by a woman was in 1808. By the mid-1850s Swiss mountaineers had ascended most of the peaks and were eagerly sought as mountain guides. Edward Whymper reached the top of the Matterhorn in 1865 (after seven attempts), and in 1938 the last of the six great north faces of the Alps was climbed with the first ascent of the Eiger Nordwand (north face of the Eiger). Important geological concepts were established as naturalists began studying
936-451: A median range of 0.24% to 1.49%. IFRs rise as a function of age (from 0.002% at age 10 and 0.01% at age 25, to 0.4% at age 55, 1.4% at age 65, 4.6% at age 75, and 15% at age 85). These rates vary by a factor of ≈10,000 across the age groups. For comparison, the IFR for middle-aged adults is two orders of magnitude higher than the annualised risk of a fatal automobile accident and much higher than
1040-681: A permanent laboratory exists inside a glacier under the Jungfraujoch , devoted exclusively to the study of Alpine glaciers. COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic ), caused by severe acute respiratory syndrome coronavirus 2 ( SARS-CoV-2 ), began with an outbreak of COVID-19 in Wuhan , China, in December 2019. It spread to other areas of Asia, and then worldwide in early 2020. The World Health Organization (WHO) declared
1144-730: A profit-centred event. UTMB later issued a response stating that the CMTR race organisers had stated they were leaving Whistler prior to the setup of the new UTMB race. In 2023, U.S. ultrarunner Corrinne Malcolm reported that she had been fired from her role as a UTMB commentator after four years, and claimed she had been told she was "too outspoken." Malcolm, who is also a commentator for the Western States Endurance Run , had previously expressed criticism of UTMB partner Ironman . In January 2024, elite trail runners Kilian Jornet and Zach Miller sparked further controversy in
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#17327936859001248-824: A random sample have consistently found that total infections considerably exceed the reported case counts. Many countries, early on, had official policies to not test those with only mild symptoms. The strongest risk factors for severe illness are obesity, complications of diabetes , anxiety disorders, and the total number of conditions. During the start of the COVID-19 pandemic it was not clear whether young people were less likely to be infected, or less likely to develop symptoms and be tested. A retrospective cohort study in China found that children and adults were just as likely to be infected. Among more thorough studies, preliminary results from 9 April 2020 found that in Gangelt ,
1352-410: A social phenomenon, not just a biological one. Time reported in March 2024 that expert opinions differ on whether or not COVID-19 is considered endemic or pandemic, and that the WHO continued to call the disease a pandemic on its website. During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus", "Wuhan coronavirus", "the coronavirus outbreak" and
1456-451: A test. Conversely, deaths of people who died from underlying conditions following a positive test may be included. Countries such as Belgium include deaths from suspected cases, including those without a test, thereby increasing counts. Official death counts have been claimed to underreport the actual death toll, because excess mortality (the number of deaths in a period compared to a long-term average) data show an increase in deaths that
1560-417: A third race was added in 2009: "Sur les Traces des Ducs de Savoie". A fourth shorter "running" event - Orsières - Champex - Chamonix - was added in 2014. La Petite Trotte à Léon is a non-competitive team event started in 2011. Each team is made of two or three members for safety. The route and direction of the course change every year. In 2015, it was run counterclockwise. Today, the races consist of
1664-597: A total elevation gain of around 10,040 metres (32,940 ft). It is widely regarded as one of the most difficult foot races in the world, and one of the largest with more than 2,500 starters. It is one of several races during a week-long festival based around Chamonix in France, and is a race of the Ultra-Trail World Tour . The races have strict entry and qualification requirements attained by accumulating enough race points through qualifying trail races over
1768-604: A tunnel 1.6 km (1 mi) long was built along the route of the pass in the mid-19th century. With a summit of 2,469 m (8,100 ft), the Great St Bernard Pass is one of the highest in the Alps, crossing the Italian-Swiss border east of the Pennine Alps along the flanks of Mont Blanc. The pass was used by Napoleon Bonaparte to cross 40,000 troops in 1800. The Mont Cenis pass has been
1872-646: Is sedimentary rock formed during mountain building. The Alpine orogeny occurred in ongoing cycles through to the Paleogene causing differences in folded structures, with a late-stage orogeny causing the development of the Jura Mountains . A series of tectonic events in the Triassic, Jurassic and Cretaceous periods caused different paleogeographic regions. The Alps are subdivided by different lithology (rock composition) and nappe structures according to
1976-625: Is a list of 2022 and 2023 UTMB World Series events. The expansion of the World Series through the UTMB Whistler race has caused controversy over allegations that it has forced out a locally organised race from Coast Mountain Trail Running. The announcement by UTMB and Vail Resorts was met with public backlash and fears that UTMB is attempting to create a monopoly by taking over current community based races and turning them into
2080-518: Is associated with COVID-19 and is reported in as many as 88% of cases. The disease is mainly transmitted via the respiratory route when people inhale droplets and small airborne particles (that form an aerosol ) that infected people exhale as they breathe, talk, cough, sneeze, or sing. Infected people are more likely to transmit COVID-19 when they are physically close to other non-infected individuals. However, infection can occur over longer distances, particularly indoors. SARS‑CoV‑2 belongs to
2184-611: Is discouraged altogether by the World Health Organization (WHO), due to limited evidence of its efficacy. The severity of COVID-19 varies. It may take a mild course with few or no symptoms, resembling other common upper respiratory diseases such as the common cold . In 3–4% of cases (7.4% for those over age 65) symptoms are severe enough to cause hospitalisation. Mild cases typically recover within two weeks, while those with severe or critical diseases may take three to six weeks to recover. Among those who have died,
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#17327936859002288-439: Is intended to provide acquired immunity against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), the virus that causes coronavirus disease 2019 ( COVID-19 ). Prior to the COVID-19 pandemic, an established body of knowledge existed about the structure and function of coronaviruses causing diseases like severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). This knowledge accelerated
2392-490: Is not explained by COVID-19 deaths alone. Using such data, estimates of the true number of deaths from COVID-19 worldwide have included a range from 18.2 to 33.5 million (≈27.4 million) by 18 November 2023 by The Economist , as well as over 18.5 million by 1 April 2023 by the Institute for Health Metrics and Evaluation and ≈18.2 million (earlier) deaths between 1 January 2020, and 31 December 2021, by
2496-503: Is of continental European origin, above which are stacked marine sediment nappes, topped off by nappes derived from the African plate. The Matterhorn is an example of the ongoing orogeny and shows evidence of great folding. The tip of the mountain consists of gneisses from the African plate; the base of the peak, below the glaciated area, consists of European basement rock. The sequence of Tethyan marine sediments and their oceanic basement
2600-624: Is sandwiched between rock derived from the African and European plates. The core regions of the Alpine orogenic belt have been folded and fractured in such a manner that erosion produced the characteristic steep vertical peaks of the Swiss Alps that rise seemingly straight out of the foreland areas. Peaks such as Mont Blanc, the Matterhorn, and high peaks in the Pennine Alps, the Briançonnais, and Hohe Tauern consist of layers of rock from
2704-452: Is the ratio of deaths to diagnoses. This metric can be misleading because of the delay between symptom onset and death and because testing focuses on symptomatic individuals. Based on Johns Hopkins University statistics, the global CFR was 1.02 percent (6,881,955 deaths for 676,609,955 cases) as of 10 March 2023. The number varies by region and has generally declined over time. Several variants have been named by WHO and labelled as
2808-406: Is the seventh known coronavirus to infect people, after 229E , NL63 , OC43 , HKU1 , MERS-CoV , and the original SARS-CoV . The standard method of testing for presence of SARS-CoV-2 is a nucleic acid test , which detects the presence of viral RNA fragments. As these tests detect RNA but not infectious virus, its "ability to determine duration of infectivity of patients is limited." The test
2912-614: Is typically done on respiratory samples obtained by a nasopharyngeal swab ; however, a nasal swab or sputum sample may also be used. The WHO has published several testing protocols for the disease. Preventive measures to reduce the chances of infection include getting vaccinated, staying at home or spending more time outdoors, avoiding crowded places, keeping distance from others, wearing a mask in public, ventilating indoor spaces, managing potential exposure durations, washing hands with soap and water often and for at least twenty seconds, practising good respiratory hygiene, and avoiding touching
3016-534: The Adriatic Sea and Slovenia . To the south it dips into northern Italy and to the north extends to the southern border of Bavaria in Germany. In areas like Chiasso , Switzerland, and Allgäu , Bavaria, the demarcation between the mountain range and the flatlands are clear; in other places such as Geneva , the demarcation is less clear. The Alps are found in the following countries: Austria (28.7% of
3120-678: The Col de la Seigne (2,516 m) to enter Italy, and follows the ridge of the Mont-Favre (2,435 m) before going down to Courmayeur (1,190 m), the second life base. It climbs again to the Refuge Bertone (1,989 m) and Arnuva (1,769 m) before reaching its highest point, the Grand Col Ferret (2,537 m), which also marks the border with Switzerland. The path goes down again to Praz de Fort (1,151 m) via La Fouly (1,593 m) before reaching
3224-915: The Colle della Maddalena , to the north. Upon reaching the Swiss border, the line of the main chain heads approximately east-northeast, a heading it follows until its end near Vienna. The northeast end of the Alpine arc, directly on the Danube , which flows into the Black Sea, is the Leopoldsberg near Vienna. In contrast, the southeastern part of the Alps ends on the Adriatic Sea in the area around Trieste towards Duino and Barcola . The Alps have been crossed for war and commerce, and by pilgrims, students and tourists. Crossing routes by road, train, or foot are known as passes , and usually consist of depressions in
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3328-511: The Gotthard Base Tunnel , was opened, which connects Erstfeld in canton of Uri with Bodio in canton of Ticino by two single tubes of 57.1 km (35.5 mi). It is the first tunnel that traverses the Alps on a flat route. From 11 December 2016, it has been part of the regular railway timetable and used hourly as standard ride between Basel / Lucerne / Zürich and Bellinzona / Lugano / Milan . The highest pass in
3432-514: The Huanan Seafood Wholesale Market there, but it is possible that human-to-human transmission began earlier. Molecular clock analysis suggests that the first cases were likely to have been between October and November 2019. The scientific consensus is that the virus is most likely of a zoonotic origin, from bats or another closely related mammal. While other explanations such as speculations that SARS-CoV-2
3536-407: The Institute for Health Metrics and Evaluation estimating the true number of cases as of early 2022 to be in the billions. One measure that public health officials and policymakers have used to monitor the pandemic and guide decision-making is the test positivity rate ("percent positive"). According to Johns Hopkins in 2020, one benchmark for a "too high" per cent positive is 5%, which was used by
3640-607: The Oxford English Dictionary , the Latin Alpes might derive from a pre-Indo-European word * alb "hill"; "Albania" is a related derivation. Albania, a name not native to the region known as the country of Albania , has been used as a name for several mountainous areas across Europe. In Roman times , "Albania" was a name for the eastern Caucasus , while in the English languages "Albania" (or "Albany")
3744-764: The Pangaean supercontinent consisted of a single tectonic plate ; it broke into separate plates during the Mesozoic Era and the Tethys sea developed between Laurasia and Gondwana during the Jurassic Period. The Tethys was later squeezed between colliding plates causing the formation of mountain ranges called the Alpide belt , from Gibraltar through the Himalayas to Indonesia —a process that began at
3848-466: The Romanticists , followed by the golden age of alpinism as mountaineers began to ascend the peaks of the Alps. The Alpine region has a strong cultural identity. Traditional practices such as farming, cheesemaking, and woodworking still thrive in Alpine villages. However, the tourist industry began to grow early in the 20th century and expanded significantly after World War II, eventually becoming
3952-736: The Simplon Pass , and the Stelvio Pass . Crossing the Italian-Austrian border, the Brenner Pass separates the Ötztal Alps and Zillertal Alps and has been in use as a trading route since the 14th century. The lowest of the Alpine passes at 985 m (3,232 ft), the Semmering crosses from Lower Austria to Styria ; since the 12th century when a hospice was built there, it has seen continuous use. A railroad with
4056-602: The basic reproduction number (R 0 ) for COVID-19 in January 2020 were between 1.4 and 2.5, but a subsequent analysis claimed that it may be about 5.7 (with a 95 per cent confidence interval of 3.8 to 8.9). In December 2021, the number of cases continued to climb due to several factors, including new COVID-19 variants. As of that 28 December, 282,790,822 individuals worldwide had been confirmed as infected. As of 14 April 2022 , over 500 million cases were confirmed globally. Most cases are unconfirmed, with
4160-474: The variants of interest as specified by the World Health Organization are BA.2.86 and JN.1, and the variants under monitoring are JN.1.7, KP.2, KP.3, KP.3.1.1, JN.1.18, LB.1, and XEC. Symptoms of COVID-19 are variable, ranging from mild symptoms to severe illness. Common symptoms include headache, loss of smell and taste , nasal congestion and runny nose , cough, muscle pain , sore throat , fever, diarrhoea , and breathing difficulties . People with
4264-429: The "Wuhan coronavirus outbreak", with the disease sometimes called "Wuhan pneumonia ". In January 2020, the WHO recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 international guidelines against using geographical locations (e.g. Wuhan, China), animal species, or groups of people in disease and virus names in part to prevent social stigma . WHO finalised
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4368-615: The 15 km-long (9.3 mi) Saint Gotthard Railway Tunnel was opened connecting Lucerne in Switzerland, with Milan in Italy. 98 years later followed Gotthard Road Tunnel (16.9 km (10.5 mi) long) connecting the A2 motorway in Göschenen on the north side with Airolo on the south side, exactly like the railway tunnel. On 1 June 2016 the world's longest railway tunnel,
4472-664: The 20th century Robert Parker wrote a well-known work about the rock crystals of the Swiss Alps; at the same period a commission was established to control and standardize the naming of Alpine minerals. In the Miocene Epoch the mountains underwent severe erosion because of glaciation, which was noted in the mid-19th century by naturalist Louis Agassiz who presented a paper proclaiming the Alps were covered in ice at various intervals—a theory he formed when studying rocks near his Neuchâtel home which he believed originated to
4576-691: The 29 "four-thousanders" with at least 300 m (984 ft) of prominence. While Mont Blanc was first climbed in 1786 and the Jungfrau in 1811, most of the Alpine four-thousanders were climbed during the second half of the 19th century, notably Piz Bernina (1850), the Dom (1858), the Grand Combin (1859), the Weisshorn (1861) and the Barre des Écrins (1864); the ascent of the Matterhorn in 1865 marked
4680-486: The Alpine region. The cinnabar deposits in Slovenia are a notable source of cinnabar pigments. Alpine crystals have been studied and collected for hundreds of years and began to be classified in the 18th century. Leonhard Euler studied the shapes of crystals, and by the 19th-century crystal hunting was common in Alpine regions. David Friedrich Wiser amassed a collection of 8000 crystals that he studied and documented. In
4784-708: The Alps are difficult to quantify and likely to vary significantly in space and time. The Alps are a source of minerals that have been mined for thousands of years. In the 8th to 6th centuries, BC during the Hallstatt culture , Celtic tribes mined copper; later the Romans mined gold for coins in the Bad Gastein area. Erzberg in Styria furnishes high-quality iron ore for the steel industry. Crystals, such as cinnabar , amethyst , and quartz , are found throughout much of
4888-771: The Alps goes back to the Palaeolithic era. A mummified man ("Ötzi") , determined to be 5,000 years old, was discovered on a glacier at the Austrian–Italian border in 1991. By the 6th century BC, the Celtic La Tène culture was well established. Hannibal notably crossed the Alps with a herd of elephants, and the Romans had settlements in the region. In 1800, Napoleon crossed one of the mountain passes with an army of 40,000. The 18th and 19th centuries saw an influx of naturalists, writers, and artists, in particular,
4992-746: The Austroalpine peaks underwent an event in the Cretaceous Period, the two areas show distinct differences in nappe formations. Flysch deposits in the Southern Alps of Lombardy probably occurred in the Cretaceous or later. Peaks in France, Italy and Switzerland lie in the "Houillière zone", which consists of basement with sediments from the Mesozoic Era. High "massifs" with external sedimentary cover are more common in
5096-456: The CCC to allow more runners to take part. The registrations were sold out in only 2 weeks. In 2007, it was decided that runners must qualify, by running qualifying races beforehand and gaining points. That year the limit of 5,000 runners was reached less than 24 hours after registration opened. For the 2008 event, 6,000 runners registered in only 8 minutes, 5 months before the race. For the 2009 event,
5200-521: The Eastern and South-Western Alps. The underlying mechanisms that jointly drive the present-day uplift pattern are the isostatic rebound due to the melting of the last glacial maximum ice-cap or long-term erosion, detachment of the Western Alpine subducting slab, mantle convection as well as ongoing horizontal convergence between Africa and Europe, but their relative contributions to the uplift of
5304-592: The French–Italian border, and at 4,809 m (15,778 ft) is the highest mountain in the Alps. The Alpine region area contains 128 peaks higher than 4,000 m (13,000 ft) . The altitude and size of the range affect the climate in Europe; in the mountains, precipitation levels vary greatly and climatic conditions consist of distinct zones. Wildlife such as ibex live in the higher peaks to elevations of 3,400 m (11,155 ft), and plants such as edelweiss grow in rocky areas in lower elevations as well as in higher elevations. Evidence of human habitation in
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#17327936859005408-462: The Greek goddess Alphito , whose name is related to alphita , the "white flour"; alphos , a dull white leprosy; and finally the Proto-Indo-European word *albʰós . Similarly, the river god Alpheus is also supposed to derive from the Greek alphos and means whitish. In his commentary on the Aeneid of Virgil , the late fourth-century grammarian Maurus Servius Honoratus says that all high mountains are called Alpes by Celts. According to
5512-419: The UTMB World Series Finals. Running Stones can be collected by finishing a 20K, 50K, 100K or 100M race of the UTMB World Series circuit. Running Stones are recorded on the runner’s account and each Running Stone improves the odds in the lottery. A valid UTMB Index is achieved by completing at least one UTMB World Series Major, Event, or Qualifier race in the relevant category within the previous 24 months. Below
5616-409: The Ultra Trail World Tour (UTWT). As of 2022, the UTMB World Series will integrate four levels of events: From the Year 2023, access for qualification of UTMB World Series Finals will have substantial changes, with obtaining Running Stones as the sole way of lottery entry, replacing ITRA Points. To enter the lottery, they need to: A Running Stone provides one entry in the lottery to participate in
5720-588: The WHO in the past. As of 10 March 2023, more than 6.88 million deaths had been attributed to COVID-19. The first confirmed death was in Wuhan on 9 January 2020. These numbers vary by region and over time, influenced by testing volume, healthcare system quality, treatment options, government response, time since the initial outbreak, and population characteristics, such as age, sex, and overall health. Multiple measures are used to quantify mortality. Official death counts typically include people who died after testing positive. Such counts exclude deaths without
5824-419: The WHO, US, European Union, and Australia. On 12 November 2022, the WHO released its Global Vaccine Market Report. The report indicated that "inequitable distribution is not unique to COVID-19 vaccines"; countries that are not economically strong struggle to obtain vaccines. On 14 November 2022, the first inhalable vaccine was introduced, developed by Chinese biopharmaceutical company CanSino Biologics , in
5928-481: The Western Alps and were affected by Neogene Period thin-skinned thrusting whereas the Eastern Alps have comparatively few high peaked massifs. Similarly the peaks in eastern Switzerland extending to western Austria (Helvetic nappes) consist of thin-skinned sedimentary folding that detached from former basement rock. In simple terms, the structure of the Alps consists of layers of rock of European, African, and oceanic (Tethyan) origin. The bottom nappe structure
6032-525: The alps is the Col de l'Iseran in Savoy (France) at 2,770 m (9,088 ft), followed by the Stelvio Pass in northern Italy at 2,756 m (9,042 ft); the road was built in the 1820s. The Union Internationale des Associations d'Alpinisme (UIAA) has defined a list of 82 "official" Alpine summits that reach at least 4,000 m (13,123 ft). The list includes not only mountains, but also subpeaks with little prominence that are considered important mountaineering objectives. Below are listed
6136-448: The broad family of viruses known as coronaviruses . It is a positive-sense single-stranded RNA (+ssRNA) virus, with a single linear RNA segment. Coronaviruses infect humans, other mammals, including livestock and companion animals, and avian species. Human coronaviruses are capable of causing illnesses ranging from the common cold to more severe diseases such as Middle East respiratory syndrome (MERS, fatality rate ≈34%). SARS-CoV-2
6240-744: The central and western portions. The variances in nomenclature in the region spanned by the Alps make classification of the mountains and subregions difficult, but a general classification is that of the Eastern Alps and Western Alps with the divide between the two occurring in eastern Switzerland according to geologist Stefan Schmid, near the Splügen Pass . The highest peaks of the Western Alps and Eastern Alps, respectively, are Mont Blanc, at 4,810 m (15,780 ft), and Piz Bernina , at 4,049 m (13,284 ft). The second-highest major peaks are Monte Rosa , at 4,634 m (15,203 ft), and Ortler , at 3,905 m (12,810 ft), respectively. A series of lower mountain ranges run parallel to
6344-470: The centre of a major infection cluster in Germany, 15 per cent of a population sample tested positive for antibodies . Screening for COVID-19 in pregnant women in New York City , and blood donors in the Netherlands, found rates of positive antibody tests that indicated more infections than reported. Seroprevalence -based estimates are conservative as some studies show that persons with mild symptoms do not have detectable antibodies. Initial estimates of
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#17327936859006448-632: The city of Shanghai, China. For the first two years of the pandemic, no specific and effective treatment or cure was available. In 2021, the European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) approved the oral antiviral protease inhibitor , Paxlovid (nirmatrelvir plus the HIV antiviral ritonavir ), to treat adult patients. FDA later gave it an EUA. Most cases of COVID-19 are mild. In these, supportive care includes medication such as paracetamol or NSAIDs to relieve symptoms (fever, body aches, cough), adequate intake of oral fluids and rest. Good personal hygiene and
6552-433: The cumulative number of infected individuals (including asymptomatic and undiagnosed infections and excluding vaccinated infected individuals). It is expressed in percentage points. Other studies refer to this metric as the infection fatality risk . In November 2020, a review article in Nature reported estimates of population-weighted IFRs for various countries, excluding deaths in elderly care facilities, and found
6656-441: The development of various vaccine platforms during early 2020. The initial focus of SARS-CoV-2 vaccines was on preventing symptomatic and severe illness. The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. As of March 2023, more than 5.5 billion people had received one or more doses (11.8 billion in total) in over 197 countries. The Oxford-AstraZeneca vaccine
6760-424: The dominant industry by the end of the century. The Winter Olympic Games have been hosted in the Swiss, French, Italian, Austrian and German Alps. As of 2010, the region is home to 14 million people and has 120 million annual visitors. The English word Alps comes from the Latin Alpes . The Latin word Alpes could possibly come from the adjective albus ("white"), or could possibly come from
6864-527: The draw. The 2020 edition of the race was cancelled due to the coronavirus pandemic , with all registrants automatically receiving a 55% refund and given the option of reserving a spot for 2021, 2022, or 2023. On May 6, 2021, UTMB Group made a strategic alliance with famous Triathlon race operator IRONMAN Group, and launched a brand new series of Trail Running races: UTMB World Series , with Ultra-Trail du Mont-Blanc to be renamed as UTMB World Series Finals . The annual final competition of this series replaced
6968-404: The end of the Mesozoic and continues into the present. The formation of the Alps was a segment of this orogenic process, caused by the collision between the African and the Eurasian plates that began in the late Cretaceous Period. Under extreme compressive stresses and pressure, marine sedimentary rocks were uplifted, forming characteristic recumbent folds , and thrust faults . As
7072-495: The end of the golden age of alpinism . Karl Blodig (1859–1956) was among the first to successfully climb all the major 4,000 m peaks. He completed his series of ascents in 1911. Many of the big Alpine three-thousanders were climbed in the early 19th century, notably the Grossglockner (1800) and the Ortler (1804), although some of them were climbed only much later, such at Mont Pelvoux (1848), Monte Viso (1861) and La Meije (1877). The first British Mont Blanc ascent by
7176-513: The eyes, nose, or mouth with unwashed hands. Those diagnosed with COVID-19 or who believe they may be infected are advised by healthcare authorities to stay home except to get medical care, call ahead before visiting a healthcare provider, wear a face mask before entering the healthcare provider's office and when in any room or vehicle with another person, cover coughs and sneezes with a tissue, regularly wash hands with soap and water and avoid sharing personal household items. A COVID-19 vaccine
7280-432: The following; The route follows the Tour du Mont Blanc hiking path that is usually completed in 7 to 9 days by hikers. This is a loop around Mont Blanc . It starts from Chamonix (1,035 m) and goes up to the Col de Voza (1,653 m) to reach Les Contamines (1,150 m), which is the first life base. It then climbs to the Croix du Bonhomme (2,479 m) before going back down to Les Chapieux (1,549 m). The path then runs up to
7384-474: The general public beginning in December 2020, made available through government and international programs such as COVAX , aiming to provide vaccine equity . Treatments include novel antiviral drugs and symptom control. Common mitigation measures during the public health emergency included travel restrictions , lockdowns , business restrictions and closures, workplace hazard controls , mask mandates , quarantines, testing systems, and contact tracing of
7488-665: The infected. The pandemic caused severe social and economic disruption around the world, including the largest global recession since the Great Depression . Widespread supply shortages , including food shortages , were caused by supply chain disruptions and panic buying . Reduced human activity led to an unprecedented temporary decrease in pollution . Educational institutions and public areas were partially or fully closed in many jurisdictions, and many events were cancelled or postponed during 2020 and 2021. Telework became much more common for white-collar workers as
7592-487: The issue of respiratory failure. Existing drugs such as hydroxychloroquine , lopinavir/ritonavir , and ivermectin are not recommended by US or European health authorities, as there is no good evidence they have any useful effect. The antiviral remdesivir is available in the US, Canada, Australia, and several other countries, with varying restrictions; however, it is not recommended for use with mechanical ventilation, and
7696-648: The main chain of the Alps, including the French Prealps in France and the Jura Mountains in Switzerland and France. The secondary chain of the Alps follows the watershed from the Mediterranean Sea to the Wienerwald , passing over many of the highest and most well-known peaks in the Alps. From the Colle di Cadibona to Col de Tende it runs westwards, before turning to the northwest and then, near
7800-576: The majority of the unreported 9.5 million deaths believed to be direct deaths due the virus, rather than indirect deaths. Some deaths were because people with other conditions could not access medical services . A December 2022 WHO study estimated excess deaths from the pandemic during 2020 and 2021, again concluding ≈14.8 million excess early deaths occurred, reaffirming and detailing their prior calculations from May as well as updating them, addressing criticisms. These numbers do not include measures like years of potential life lost and may make
7904-773: The mountains in which a valley leads from the plains and hilly pre-mountainous zones. In the medieval period hospices were established by religious orders at the summits of many of the main passes. The most important passes are the Col de l'Iseran (the highest), the Col Agnel , the Brenner Pass , the Mont-Cenis , the Great St. Bernard Pass , the Col de Tende , the Gotthard Pass , the Semmering Pass ,
8008-495: The official names COVID-19 and SARS-CoV-2 on 11 February 2020. Tedros Adhanom Ghebreyesus explained: CO for corona , VI for virus , D for disease and 19 for when the outbreak was first identified (31 December 2019). WHO additionally uses "the COVID-19 virus" and "the virus responsible for COVID-19" in public communications. WHO named variants of concern and variants of interest using Greek letters . The initial practice of naming them according to where
8112-831: The orogenic events that affected them. The geological subdivision differentiates the Western, Eastern Alps, and Southern Alps: the Helveticum in the north, the Penninicum and Austroalpine system in the centre and, south of the Periadriatic Seam, the Southern Alpine system . According to geologist Stefan Schmid, because the Western Alps underwent a metamorphic event in the Cenozoic Era while
8216-534: The outbreak a public health emergency of international concern (PHEIC) on 30 January 2020, and assessed the outbreak as having become a pandemic on 11 March. COVID-19 symptoms range from asymptomatic to deadly, but most commonly include fever, sore throat , nocturnal cough , and fatigue. Transmission of the virus is often through airborne particles . Mutations have produced many strains (variants) with varying degrees of infectivity and virulence . COVID-19 vaccines were developed rapidly and deployed to
8320-407: The pandemic 2021's leading cause of death . The time between symptom onset and death ranges from 6 to 41 days, typically about 14 days. Mortality rates increase as a function of age. People at the greatest mortality risk are the elderly and those with underlying conditions. The infection fatality ratio (IFR) is the cumulative number of deaths attributed to the disease divided by
8424-495: The pandemic evolved. Misinformation circulated through social media and mass media , and political tensions intensified . The pandemic raised issues of racial and geographic discrimination , health equity , and the balance between public health imperatives and individual rights . The WHO ended the PHEIC for COVID-19 on 5 May 2023. The disease has continued to circulate, but as of 2024, experts were uncertain as to whether it
8528-478: The population's age structure and the age-specific pattern of infections. There have also been reviews that have compared the fatality rate of this pandemic with prior pandemics, such as MERS-CoV. For comparison the infection mortality rate of seasonal flu in the United States is 0.1%, which is 13 times lower than COVID-19. Another metric in assessing death rate is the case fatality ratio (CFR), which
8632-465: The previous two-year period. In 2016 and 2017, 42% and 35% of runners did not finish the UTMB race. While the best runners complete the loop in slightly more than 20 hours, most runners take 32 to 46 hours to reach the finish line. Most runners will have to run through two nights to complete the race. Since 2006, a second race Courmayeur - Champex - Chamonix (half-loop) has also been organised, and
8736-448: The qualifying criteria were tightened to limit the number of qualifying runners, and a draw was introduced to make entry fairer, giving an equal chance to all qualifiers, and making registration more orderly. Despite the stricter criteria, 10% of qualifying entrants were still denied a place, so the organisers raised entry standards still further for the 2010 event so that selection would be based more on capability and experience than luck of
8840-678: The range's area), Italy (27.2%), France (21.4%), Switzerland (13.2%), Germany (5.8%), Slovenia (3.6%), Liechtenstein (0.08%) and Monaco (0.001%). The highest portion of the range is divided by the glacial trough of the Rhône valley, from Mont Blanc to the Matterhorn and Monte Rosa on the southern side, and the Bernese Alps on the northern. The peaks in the easterly portion of the range, in Austria and Slovenia, are smaller than those in
8944-705: The rapid expansion of the UTMB World Series, sporting rules, and community engagement. While the meeting was described as productive, with both parties expressing a desire for continued dialogue, it was notable that Kilian Jornet did not participate in the 2024 UTMB edition. Alps The Alps ( / æ l p s / ) are one of the highest and most extensive mountain ranges in Europe , stretching approximately 1,200 km (750 mi) across eight Alpine countries (from west to east): Monaco , France , Switzerland , Italy , Liechtenstein , Germany , Austria and Slovenia . The Alpine arch extends from Nice on
9048-413: The rising peaks underwent erosion, a layer of marine flysch sediments was deposited in the foreland basin , and the sediments became involved in younger folds as the orogeny progressed. Coarse sediments from the continual uplift and erosion were later deposited in foreland areas north of the Alps. These regions in Switzerland and Bavaria are well-developed, containing classic examples of flysch , which
9152-410: The risk of dying from seasonal influenza . In December 2020, a systematic review and meta-analysis estimated that population-weighted IFR was 0.5% to 1% in some countries (France, Netherlands, New Zealand, and Portugal), 1% to 2% in other countries (Australia, England, Lithuania, and Spain), and about 2.5% in Italy. This study reported that most of the differences reflected corresponding differences in
9256-522: The rock formations of the Alps in the 18th century. In the mid-19th century, the now-defunct idea of geosynclines was used to explain the presence of "folded" mountain chains. This theory was replaced in the mid-20th century by the theory of plate tectonics . The formation of the Alps (the Alpine orogeny ) was an episodic process that began about 300 million years ago. In the Paleozoic Era
9360-427: The route was 166 km long with a total elevation gain of 9500m. A more detailed profile can be found on the official website: UTMB profile . The race's popularity and its entry rate grew significantly since it was first held. The number of entrants doubled from 700 in 2003 to 1,400 in 2004. In 2005, the limit of 5,000 runners was reached 7 months after registration opened. In 2006, the organisers decided to create
9464-496: The same infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: one respiratory symptom cluster with cough, sputum , shortness of breath, and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhoea. In people without prior ear, nose, and throat disorders, loss of taste combined with loss of smell
9568-752: The summer months and where huts and hay barns can be found, sometimes constituting tiny hamlets. Therefore, the term "the Alps", as a reference to the mountains, is a misnomer. The term for the mountain peaks varies by nation and language: words such as Horn , Kogel , Kopf , Gipfel , Spitze , Stock , and Berg are used in German-speaking regions; Mont , Pic , Tête , Pointe , Dent , Roche , and Aiguille in French-speaking regions; and Monte , Picco , Corno , Punta , Pizzo , or Cima in Italian-speaking regions. The Alps are
9672-399: The third life base, Champex d'en Bas (1,391 m). The last part includes two rather low cols: Bovine (1,987 m) and Les Tseppes (1,932 m), separated by Trient (1,300 m). On the descent to Vallorcine (1,260 m), the path re-enters France and crosses Argentière (1,260 m) before finishing at Chamonix , its starting point. The route varies slightly every year, sometimes for safety reasons. In 2010,
9776-411: The time from symptom onset to death has ranged from two to eight weeks. Prolonged prothrombin time and elevated C-reactive protein levels on admission to the hospital are associated with severe course of COVID-19 and with a transfer to intensive care units (ICU). Between 5% and 50% of COVID-19 patients experience long COVID , a condition characterised by long-term consequences persisting after
9880-694: The typical convalescence period of the disease. The most commonly reported clinical presentations are fatigue and memory problems, as well as malaise , headaches, shortness of breath , loss of smell, muscle weakness , low fever and cognitive dysfunction . Many countries attempted to slow or stop the spread of COVID-19 by recommending, mandating or prohibiting behaviour changes, while others relied primarily on providing information. Measures ranged from public advisories to stringent lockdowns. Outbreak control strategies are divided into elimination and mitigation. Experts differentiate between elimination strategies (known as " zero-COVID ") that aim to completely stop
9984-558: The ultra-running community when a private email they sent to fellow professional athletes was leaked. The email suggested finding an alternative race to the Ultra-Trail du Mont-Blanc (UTMB) for 2024, which some interpreted as a call for boycott. Following public backlash, Jornet clarified that their intention was not to organize a boycott but to raise awareness about concerns within the sport. On January 23, 2024, Jornet and Miller met with UTMB Group representatives to discuss issues such as
10088-543: The variants were identified (e.g. Delta began as the " Indian variant") is no longer common. A more systematic naming scheme reflects the variant's PANGO lineage (e.g., Omicron 's lineage is B.1.1.529) and is used for other variants. SARS-CoV-2 is a virus closely related to bat coronaviruses , pangolin coronaviruses, and SARS-CoV . The first known outbreak (the 2019–2020 COVID-19 outbreak in mainland China ) started in Wuhan , Hubei, China, in December 2019. Many early cases were linked to people who had visited
10192-539: The various orogenies including exposures of basement rock. Due to the ever-present geologic instability, earthquakes continue in the Alps to this day. Typically, the largest earthquakes in the alps have been between magnitude 6 and 7 on the Richter scale. Geodetic measurements show ongoing topographic uplift at rates of up to about 2.5 mm per year in the North, Western and Central Alps, and at ~1 mm per year in
10296-548: The west in the Bernese Oberland. Because of his work he came to be known as the "father of the ice-age concept" although other naturalists before him put forth similar ideas. Agassiz studied glacier movement in the 1840s at the Unteraar Glacier where he found the glacier moved 100 m (328 ft) per year, more rapidly in the middle than at the edges. His work was continued by other scientists and now
10400-548: The western Mediterranean to Trieste on the Adriatic and Vienna at the beginning of the Pannonian Basin . The mountains were formed over tens of millions of years as the African and Eurasian tectonic plates collided. Extreme shortening caused by the event resulted in marine sedimentary rocks rising by thrusting and folding into high mountain peaks such as Mont Blanc and the Matterhorn . Mont Blanc spans
10504-443: Was accidentally released from a laboratory have been proposed, as of 2021 these were not supported by evidence. Official "case" counts refer to the number of people who have been tested for COVID-19 and whose test has been confirmed positive according to official protocols whether or not they experienced symptomatic disease. Due to the effect of sampling bias , studies which obtain a more accurate number by extrapolating from
10608-484: Was occasionally used as a name for Scotland , although it is more likely derived from the Latin word albus , the colour white. In modern languages the term alp , alm , albe or alpe refers to a grazing pastures in the alpine regions below the glaciers, not the peaks. An alp refers to a high mountain pasture, typically near or above the tree line , where cows and other livestock are taken to be grazed during
10712-457: Was still a pandemic. Pandemics and their ends are not well-defined, and whether or not one has ended differs according to the definition used. As of 24 November 2024, COVID-19 has caused 7,075,455 confirmed deaths. The COVID-19 pandemic ranks as the fifth- deadliest pandemic or epidemic in history . In epidemiology , a pandemic is defined as "an epidemic occurring over a very wide area, crossing international boundaries, and usually affecting
10816-509: Was the most widely used. According to a June 2022 study, COVID-19 vaccines prevented an additional 14.4 million to 19.8 million deaths in 185 countries and territories from 8 December 2020 to 8 December 2021. On 8 November 2022, the first recombinant protein-based COVID-19 vaccine (Novavax's booster Nuvaxovid ) was authorised for use in adults in the United Kingdom. It has subsequently received endorsement/authorisation from
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