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United States Military HIV Research Program

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The United States Military HIV Research Program ( USMHRP or MHRP ) was initiated by the United States Congress in 1986, in reaction to the threat of lost effectiveness of U.S./Allied troops due to HIV infection. The mission of MHRP is to develop an HIV-1 vaccine, provide prevention, care, and treatment, and conduct meaningful HIV/AIDS research for the global community through the President's Emergency Plan for AIDS Relief (PEPFAR). It is centered at the Walter Reed Army Institute of Research (WRAIR), and has established five international research sites in Africa and Asia ( Tanzania , Kenya , Nigeria , Uganda , and Thailand ). MHRP also partners with the Armed Forces Research Institute of Medical Sciences (AFRIMS) in Thailand. MHRP works closely with The Henry M. Jackson Foundation for the Advancement of Military Medicine (HJF) , most notably in the development of the RV144 HIV vaccine in Thailand. MHRP is the largest research program supported by the HJF.

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54-645: The MHRP is a $ 175 million program which receives funding for research and treatment endeavors from the Department of Defense ($ 28 million), PEPFAR, and other organizations such as the Bill and Melinda Gates Foundation and the National Institute of Allergy and Infectious Diseases. Some of MHRP's collaborative vaccine-as-treatment research is funded by Janssen, a division of Johnson & Johnson. MHRP studies in combination approaches to HIV are made possible by

108-457: A Master of Science in Nursing (MSN), and a Doctor of Nursing Practice (DNP) degree in five different APRN specialty options: Family Nurse Practitioner, Certified Registered Nurse Anesthesia, Adult Gerontology Clinical Nurse Specialist, Psychiatric Mental Health Nurse Practitioner , Women's Health Nurse Practitioner, as well as a Ph.D. in nursing science. The Graduate School of Nursing offers

162-487: A Master of Science in Nursing degree programs in nurse anesthesia , family nurse practitioner , perioperative clinical nursing , Psychiatric Mental Health Nurse Practitioner , and full- and part-time programs for a Ph.D. in nursing sciences. The Masters of Nursing Science and Doctor of Nursing Practice degrees at USU are accredited by the Commission on Collegiate Nursing Education, and The Nurse Anesthesia Program

216-514: A health science university and professional school of the U.S. federal government . The primary mission of the school is to prepare graduates for service to the U.S. at home and abroad as uniformed health professionals, scientists and leaders; by conducting cutting-edge, military-relevant research; by leading the Military Health System in key functional and intellectual areas; and by providing operational support to units around

270-570: A Cooperative Research and Development Agreement (CRADA) with OYE Therapeutics, a Purdue University affiliated company “working to reduce the mortality and morbidity resulting from injuries on the battlefield through the development of new life-saving strategies.” Uniformed Services University of the Health Sciences Uniformed Services University of the Health Sciences ( USU ) is

324-525: A Zika vaccine called ZIKV in only ten months, beginning clinical trial in 2016. This vaccine is not only important to maintain troop health when deploying to foreign regions where Zika is prevalent, but also for those servicemen stationed domestically because there are clusters of military bases in the southern United States where people are at risk for Zika. Preliminary data from a phase 1 clinical trial indicate that 92% of participants would be protected from Zika infection. Henry M. Jackson Foundation for

378-589: A competitive grant that they competed for from a NIH-funded Martin Delaney Collaboratorive. In 2012, a MHRP scientist named Dr. Gary R. Matyas proposed a vaccine to treat heroin addiction and prevent those who received this vaccine from contracting HIV. Matyas was awarded the NIDA Avant-Garde Award for Medications Development for this proposition, which gave him $ 1 million per year for five years to continue his research at MHRP on

432-506: A majority of Army Special Forces physicians. USU is featured in the documentary Fighting for Life . Affiliated military and civilian teaching hospitals are: Students can indicate their intent to apply for the MD/PhD program on the USU secondary application and complete the graduate school application. Applicants not selected for the graduate school are still eligible for acceptance into

486-845: A minimum of a seven-year active duty service commitment and a six-year inactive ready reserve commitment following their internship and residency after graduation. Students in the School of Medicine graduate programs are a mix of both civilians and uniformed officers of various ranks. They also pay no tuition or fees. Civilian students may receive stipends and uniformed graduate students continue to receive their active-duty pay and benefits while attending school at USU. The Graduate School of Nursing students are all active duty uniformed military nurses or nurses in federal civilian service. Neither pay tuition or fees at USU and both uniformed graduate students and nursing students maintain their rank and continue to receive their regular salaries while students at

540-470: A scientific milestone into an eventual public health tool. RV144 remains the only instance of successful preventative HIV vaccination. MHRP scientists are also pursuing other strategies to target multiple sub-types of HIV, including modified vaccinia virus Ankara (MVA) vaccines, which were initially developed by collaborating scientists from WRAIR, NIAID, the National Institutes of Health, and

594-711: A specific MOS/NEC/AFSC and attend the respective Service school. Service Affiliated Locations an programs include: Program Degree Level Participating Service(s) Program Degree Level Participating Service(s) Program Degree Level Participating Service(s) Program Degree Level Participating Service(s) Program Degree Level Participating Service(s) Program Degree Level Participating Service(s) USU

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648-540: A tremendous untold story about military medicine: its commitment to sharing advances with service members and civilians alike. The JOTT has won 6 Federal Laboratory Consortium awards (2012, 2013, 2014, 2016, 2017, 2018). HJF supports hundreds of additional research projects at USUHS and throughout military medicine, including the Center for Prostate Disease Research, [4] the Center for the Study of Traumatic Stress, [6] and

702-737: A variety of programs, from large multi-site clinical trials to small, bench top projects, both nationally and abroad. Long-time chief executive officer and president John W. Lowe retired after 25 years of serving HJF in May 2017. Retired Army Major General (Dr.) Joseph Caravalho , Jr. was named HJF CEO and president on September 1, 2017. In 2000, HJF established the John W. Lowe Joint Office of Technology Transfer (JOTT) in partnership with USU. This department helps scientists expedite their novel inventions, devices and technologies to possible patenting and commercialization. The office's achievements vividly illustrate

756-462: A wide range of education and training requirements. Current enrolment across the programs exceeds 7,000 students per year. Only students enrolled in specific Military Occupational Specialty (MOS) / Navy Enlisted Code (NEC) / Air Force Specialty Code (AFSC) / Additional Skill Identifier (ASI) training programs of the Services are eligible for enrollment. Depending on specifics of the respective program,

810-596: Is accredited by the Commission of Education, Middle States Association of Colleges and Schools . Uniformed Services University falls under the office of the Assistant Secretary of Defense for Health Affairs . The university is similar to a federal service academy, such as the United States Military Academy , Naval Academy , Air Force Academy , United States Merchant Marine Academy , and United States Coast Guard Academy , and

864-486: Is designed to expand the student's understanding of medical and biological concepts.  Coursework covers anatomy, microbiology, neurology, genetics, etc., to ensure EMDP2 students are well-prepared to matriculate into medical school. Upon completing EMDP2 year two, students are awarded a Graduate Certificate in Cell and Molecular Biology from GMU. EMDP2 students may seek approval to take six additional courses to fulfill

918-549: Is designed to prepare students from any academic and career background to take the MCAT exam. The curriculum starts with fundamental coursework and expands into a full pre-medical curriculum. Students typically take the MCAT and begin medical school applications near the end of EMDP2 year one. Upon completing EMDP2 year one, students are awarded a Post-Baccalaureate Certificate in Pre-Medicine from GMU. The EMDP2's second year

972-543: Is fully accredited by the Council on Accreditation of Nurse Anesthesia Educational Programs (COA). Over 800 APRNs and Nurse Scientists have graduated from the GSN since 1995, and the overall certification pass rate exceeds 99% with an impressive first time pass rate of over 95%. The Post Graduate Dental College (PDC) is a degree-granting institution for active-duty personnel enrolled in branch-specific dental programs. Students of

1026-604: Is intended for motivated service members who show academic promise and whose experiences and goals align with the mission of their military services and the F. Edward Hebert School of Medicine . Selectees are assigned to USU (requires a permanent change of station to Bethesda, MD ) and placed in a supportive academic setting for a two-year period. EMDP2 includes premedical coursework , Medical College Admissions Test (MCAT) preparation, clinical experience, mentoring, and pre-health career advising. EMDP2's current civilian partner institution, George Mason University (GMU) , provides

1080-540: Is part of The Surgical Critical Care Initiative (SC@i). Created in 2013 and funded by the Department of Defense's Defense Health Program , the program "brings together clinicians and scientists to gather and analyze information ranging from simple observation to bio-banked tissue samples, and makes the resulting data available for use in computerized statistical models that, critically, produce decision guidance tools that can quickly be used to improve clinical practice and outcomes." In February 2021, USUHS and HJF entered into

1134-612: Is possible to develop an HIV vaccine. The breakthrough led to increased interest in research on RV144 and the foundation of partnerships such as the Pox-Protein Public-Private Partnership (P5), a mosaic of public and private entities that focus on building on the success of RV144. MHRP also provides study leadership, and is working with researchers around the globe to dissect the results from the RV144 trial and to design future clinical trials to translate

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1188-586: Is the newest college, established in 2017. It currently offers an Associate of Science and Bachelor of Science degrees to students at six different locations who opt to enroll in CAHS after enrolling in their Service required training program. With an average enrollment of approximately 170 students per class, the F. Edward Hébert School of Medicine is located in Bethesda, Maryland on the military installation of Naval Support Activity Bethesda (NSAB), sharing NSAB with

1242-897: The Henry M. Jackson Foundation for the Advancement of Military Medicine 's 2016 annual report, MHRP works with local programs around the world to support more than 240,000 patients on antiretroviral therapy and to make HIV testing/advising accessible to more than 1.1 million people.  Using existing in-country technical expertise and administrative infrastructure, MHRP expands partnerships with local researchers, health care services and NGOs in Africa to implement PEPFAR activities. Goals include providing counseling, testing, prevention of mother to child transmission, full access to antiretroviral therapy, home-based care, and care for orphans and vulnerable children. MHRP also conducts therapeutic research, tracks

1296-600: The Ph.D. in emerging infectious diseases , medical and clinical psychology , molecular and cellular biology , neuroscience , pathology , Environmental Health Sciences and Medical Zoology. USU also offers the Doctor of Public Health (DrPH). Master's degree programs are offered in comparative medicine , military medical history, healthcare administration and policy, health professions education, public health and tropical medicine and hygiene. There are military students in

1350-642: The U.S. Army or U.S. Air Force , or ensign in the U.S. Navy or the U.S. Public Health Service . No prior military service is required for admission to USU's medical school. Students who already hold military commissions at higher rank in the Army, Air Force and Navy are required to accept temporary administrative demotion to O-1 for medical school; officers of the U.S. Marine Corps , U.S. Space Force , U.S. Coast Guard , or National Oceanic and Atmospheric Administration Commissioned Corps must resign their existing commissions and accept commissions in as O-1s in one of

1404-443: The Advancement of Military Medicine The Henry M. Jackson Foundation for the Advancement of Military Medicine ( HJF ) is a global non-profit organization created by Congress in 1983. HJF serves as a link between the military medical community, federal and private partners, and American service members, veterans, and civilians who benefit from the foundation's research. HJF was created to support Uniformed Services University of

1458-496: The Center for Disaster and Humanitarian Assistance Medicine. [7] HJF's largest program is the U.S. Military HIV Research Program (MHRP) , whose mission is to protect U.S. military personnel and aid the international fight against HIV. Established in 1988, the program focuses on HIV vaccine development, prevention, disease surveillance, care and treatment for HIV. Contracting through the Defense Department, HJF supports

1512-567: The GMU requirements for a Master of Science in Biology . After completing the second year, gaining acceptance into a medical school, and fulfilling requirements for commissioning, students will have successfully completed the EMDP2. They will then matriculate into medical school at USU or a civilian school and earn an commission . The Graduate School of Nursing offers two Advanced Practice Degrees:

1566-481: The Graduate School of Nursing and other programs, School of Medicine students are barred from promotion. Additionally, prior-service commissioned officers must accept a demotion to O-1 in order to matriculate. Upon graduation, when these officers are promoted to O-3, half of the time spent in prior active duty service is then added to their time-in-service (TIS)/time-in-grade (TIG) and used toward promotion to

1620-575: The HIV epidemic in active-duty forces, assesses the risk of HIV exposure to deployed U.S. and allied forces overseas, and conducts all HIV-1 testing for the Army. In 2008, MHRP helped evaluate the efficacy of new Rapid Diagnostic Tests (RDT) for HIV types 1 and 2. They were developed to be able to quickly test the blood of soldiers who transfuse blood to wounded soldiers in battle situations. This technology prevents transmission of HIV, HCV, and HBV from soldier to soldier and helps keep these diseases from weakening

1674-460: The Health Sciences (USUHS) [1] and throughout the military medical community. HJF was named in honor of Washington State Senator Henry "Scoop" Jackson , who sponsored the original legislation. Senator Jackson had a long-standing commitment to military medicine and health. HJF provides scientific and management services, from infrastructure development, financial administration, clinical trials management to staffing and event planning. HJF works with

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1728-611: The Laboratory of Viral Diseases (LVD). MHRP has ongoing studies and clinical trials using different types of MVA vaccines in Uganda and Thailand, with progress milestones including partial protection and viral load reduction in monkeys being infected with Simian Immunodeficiency Virus (SIV). In addition to vaccine research, the MHRP provides prevention, care, and treatment services to the communities where they conduct research. According to

1782-478: The Public Health Service student number to six. Students attending this institution receive free tuition, as well as reimbursement for all fees. They also receive salaries and benefits as junior officers. Textbooks are issued to the students at the beginning of each semester. USU School of Medicine students are all active-duty uniformed officers during their schooling and receive pay and benefits at

1836-486: The School of Medicine are open to civilian and military applicants. Civilian students may apply to most of these programs. The faculty is composed of a mix of military and civilian professors. There is no tuition, stipends are guaranteed for three years, and no military service is required after graduation for civilian students. There also is no undergraduate teaching. The graduate program at USU currently has approximately 170 full-time graduate students. USU currently offers

1890-582: The Senior Military Colleges, such as National War College or Dwight D. Eisenhower School for National Security and Resource Strategy . Students are members of the uniformed services of the United States and receive an education in exchange for a service commitment after graduation. All medical students enter the university as commissioned officers via direct commissions in the pay grade of O-1 or rank of second lieutenant in

1944-477: The Servicemember is enrolled into either an Associate of Science Health Science (ASHS) or Bachelor of Science Health Science (BSHS) program. The technical training received by the Servicemember constitutes the discipline with the majority of General Education required for the respective degree coming via transfer credit. The CAHS does not teach courses beyond those offered to a Servicemember who enlisted for

1998-574: The Walter Reed National Military Medical Center and is located along Maryland Route 355 , across from the National Institutes of Health . The school is named in honor of former U.S. Representative Felix Edward Hébert . Typically, the first-year class is composed of 63 Army students, 51 Air Force students, 51 Navy students, and two Public Health Service students. The Class of 2010 increased

2052-591: The branch-specific dental programs are required to complete a research project on top of their studies in order to earn a degree from PDC. Only students enrolled in branch-specific dental programs are eligible to apply. The College of Allied Health Sciences was established in 2017, responding to the National Defense Authorization Act which modified USU's authorities to include undergraduate and other medical education and training programs. These programs ensure military medicine remains on

2106-448: The coursework, MCAT preparation courses, and pre-health advising on a contract basis. These services are currently provided at GMU's Science and Technology Campus (Manassas, VA) in an exclusive cohort structure. USU coordinates the clinical component, which is completed at Walter Reed National Military Medical Center , Fort Belvoir Community Hospital , and Malcolm Grow Medical Center at Andrews Air Force Base . The EMDP2's first year

2160-498: The cutting edge of providing a “Ready Medical Force” to support the American Warfighter and the Department of Defense (DoD) community around the world. These programs also provide a recruiting and retention advantage for the Services by providing valuable skill sets that can be used when servicemembers to transition into civilian life. Currently, the CAHS supports Army, Navy and Air Force Medical Enlisted Services across

2214-600: The dual vaccine. The program's most notable contribution to HIV/AIDS medical research was the RV 144 vaccine study of over 16,000 volunteers in Thailand. In September 2009, the MHRP and the Thai Ministry of Health conducted the first successful HIV/AIDS vaccine trial to show effective prevention in humans, with a final prevention rate of 31%. Although the efficacy is modest, this trial is significant because it proved that it

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2268-526: The fighting force further. Additionally, MHRP conducted the first study to characterize that current clinical testing methods can have difficulty detecting HIV viral presence in persons with acute infections. Zika, Ebola, and Middle East Respiratory Syndrome (MERS) outbreaks were responded to by MHRP, as they used their infrastructure and research experience to help develop vaccines for both local people and military personnel living in regions where those diseases were endemic. In 2014, MHRP's Uganda site conducted

2322-546: The first vaccine trial for Ebola and Marburg virus ever done in Africa. Using combination DNA vaccines, it was shown that it is safe for people to receive both vaccines in combination. The antigens conduced by these vaccines were critical in the future development of stronger Ebola vaccines in Africa. In 2015, the Uganda site conducted a uniquely extensive study of Ebola survivors, finding that many were suffering from chronic malaise including hearing and vision loss up to 21 months post-infection. MHRP scientists under WRAIR developed

2376-611: The grade of O-1 ( second lieutenant for the Army and Air Force and ensign for the Navy and Public Health Service) – unless the student was prior service at a higher rank then that student will wear the O-1 rank but be paid at their previous pay grade. Upon graduation, medical students are promoted to the grade of O-3, ( captain for the Army and Air Force, lieutenant for the Navy and Public Health Service), and are expected to serve at least seven years after residency on active duty and six years in

2430-458: The graduate programs, most notably the public health and tropical medicine programs and clinical psychology program. Generally, military students were in the military before beginning their graduate training, but some commission as they enter their programs. The Enlisted to Medical Degree Preparatory Program (EMDP2) program is a two-year, full-time education program for enlisted members of the military to prepare for medical school applications. It

2484-484: The inactive ready reserve. Students graduating from the School of Medicine receive four years' credit toward military retirement once 20 years has been reached through military graduate medical education (residency/fellowship), practicing, and prior-service (if applicable). When the school was first formed, the United States Congress weighed whether to make each student a cadet or midshipman (like

2538-477: The medical school. The combined MD/PhD program requires the same military commitment as the school of medicine. Three MD/PhD degrees are currently offered; neuroscience (NES), molecular and cell biology (MCB), and emerging infectious diseases (EID). Students remain civilian until graduate school requirements are completed. Degrees are not granted until completion of both graduate and medical requirements. The graduate programs in biomedical sciences and public health in

2592-409: The military service academies) or to give students full active-duty officer status and promotion benefits. A compromise was reached whereby medical students were commissioned as O-1 grade officers, were not promoted while enrolled in the School of Medicine, and do not receive time in grade or time in service while enrolled in USU. However, this status puts USU Medical Students in a unique position; unlike

2646-494: The other three authorized services. Prior military service students in the Graduate School of Nursing or School of Medicine PhD programs may keep their officer rank, or will be commissioned as O-1 if previously enlisted. Students pay no tuition or fees and receive the full salary and benefits of a uniformed military officer throughout their time at the university. In return, all military students incur an active duty commitment proportionate to their time at USU. Medical students have

2700-627: The rank of major or lieutenant commander (O-4). However, as of 2008 , prior service officers will be paid their former base pay while attending School of Medicine. The curriculum at the School of Medicine begins with 1.5 years of basic sciences organized into organ-system based modules called "Molecules to Military Medicine". Additional courses include Parasitology , Combat Medical Skills, Military Medical History, Officer Professional Development, Military Applied Physiology, Epidemiology, and several other courses. The clerkship year begins in January of

2754-579: The second year, and is followed by the USMLE Step 1. After Step 1, students participate in an integrated advanced didactic module, "Bench to Bedside and Beyond", and then begin fourth year clerkships/subinternships. These clerkships are done at various military hospitals across the country. Approximately 80 percent of military physicians reaching 20 or more years of military service are graduates of USU. A majority of medical corps leadership positions are occupied by graduates of USU. Graduates also make up

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2808-557: The university. The postgraduate dental college offers a Master of Science in Oral Biology degree to students enrolled in selected graduate dental education programs of the Army, Air Force, and Navy. USU is one of many federal service graduate-level professional schools such as the Naval Postgraduate School , which has several Master of Science and Ph.D. programs. The College of Allied Health Sciences (CAHS)

2862-561: The work of the U.S. Army Medical Research Directorate-Africa in Nairobi, Kenya; Dar es Salaam, Tanzania; and Kampala, Uganda. HJF employs more than 2,600 scientific, medical, management and administrative personnel around the world. HJF also manages endowments for USUHS and promotes government-civilian partnerships [8] through its Public-Private Partnerships division, part of HJF's Strategic Initiatives. [9] Duke University Medical Center has received support services through HJF. The HJF

2916-711: The world. The university consists of the F. Edward Hébert School of Medicine , a medical school , which includes a full health sciences graduate education program, the Daniel K. Inouye Graduate School of Nursing , the Postgraduate Dental College, and the College of Allied Health Sciences. The university's main campus is located in Bethesda, Maryland . USU was established in 1972 under legislation sponsored by U.S. Representative Felix Edward Hébert of Louisiana . It graduated its first class in 1980. USU

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