California Institution for Men ( CIM ) is a male-only state prison located in the city of Chino , San Bernardino County, California . It is often colloquially referenced as "Chino". In turn, locals call the prison "Chino Men's" or just "Men's" to avoid confusion with the city itself.
118-481: CIM is a 2,500-acre (1,000 ha) facility located east of Los Angeles on arid farmland. Facilities include: As of Fiscal Year 2006/2007, CIM had 2,327 staff and an annual budget of $ 232.2 million. As of February, 2012 it had a design capacity of 2,976 but a total institution population of 5,266, for an occupancy rate of 177 percent. As of April 30, 2020, CIM was incarcerating people at 112.8% of its design capacity, with 3,357 occupants. CIM opened in 1941 and "was
236-494: A strain of coronavirus known as "severe acute respiratory syndrome coronavirus 2" ( SARS-CoV-2 ). COVID-19 is mainly transmitted when people breathe in air contaminated by droplets / aerosols and small airborne particles containing the virus. Infected people exhale those particles as they breathe, talk, cough, sneeze, or sing. Transmission is more likely the closer people are. However, infection can occur over longer distances, particularly indoors. The transmission of
354-465: A business exodus from Downtown Los Angeles since the COVID-19 pandemic , the city's urban core is evolving as a cultural center with the world's largest showcase of architecture designed by Frank Gehry . On September 4, 1781, a group of 44 settlers known as " Los Pobladores " founded the pueblo (town) they called El Pueblo de Nuestra Señora la Reina de los Ángeles , 'The Town of Our Lady
472-419: A certain critical size, generally thought to be <100μm diameter, evaporate faster than they settle; due to that fact, they form respiratory aerosol particles that remain airborne for a long period of time over extensive distances. Infectivity can begin four to five days before the onset of symptoms. Infected people can spread the disease even if they are pre-symptomatic or asymptomatic . Most commonly,
590-569: A commercial diver training program started at CIM. In following years, the program's graduates had much success in finding jobs after release from prison and a recidivism rate of only 12 percent. The program was "closed in 2003 due to budget constraints," but reopened in 2006. Inmate Kevin Cooper escaped from CIM in 1983. In retrospect, factors that may have contributed to the escape included conviction "under an alias," an undetected "history of escaping from jails and mental hospitals," and "a hole in
708-480: A fence" surrounding CIM. Three days after Cooper's escape, four people were found dead in nearby Chino Hills , and Cooper was later convicted of murdering them. However, there have been doubts raised as to Cooper's guilt over the years. In 1987, officials of the city of Chino opposed a plan to build a ward at CIM for inmates with HIV / AIDS because they "believe[d] it would threaten the community." After "Corrections Department officials announced they wouldn't increase
826-422: A higher risk of developing severe symptoms. Some complications result in death. Some people continue to experience a range of effects ( long COVID ) for months or years after infection, and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease. COVID‑19 transmission occurs when infectious particles are breathed in or come into contact with
944-485: A profit; the other, according to an analysis of contemporary newspaper reports, was the 1932 Summer Olympics , also held in Los Angeles. Racial tensions erupted on April 29, 1992, with the acquittal by a Simi Valley jury of four Los Angeles Police Department (LAPD) officers captured on videotape beating Rodney King , culminating in large-scale riots . In 1994, the magnitude 6.7 Northridge earthquake shook
1062-423: A range of effects, such as fatigue , for prolonged periods after an initial COVID-19 infection. This is the result of a condition called long COVID , which can be described as a range of persistent symptoms that continue for months or years. Long-term damage to organs has been observed after the onset of COVID-19. Multi-year studies are underway to further investigate the protracted effects of long COVID. Reducing
1180-507: A single type, where industrial uses were prohibited. The proscriptions included barns, lumber yards, and any industrial land use employing machine-powered equipment. These laws were enforced against industrial properties after the fact. These prohibitions were in addition to existing activities that were already regulated as nuisances. These included explosives warehousing, gas works, oil drilling, slaughterhouses, and tanneries . Los Angeles City Council also designated seven industrial zones within
1298-438: Is Mount San Antonio , locally known as Mount Baldy, which reaches 10,064 feet (3,068 m). Further afield, the highest point in southern California is San Gorgonio Mountain , 81 miles (130 km) east of downtown Los Angeles, with a height of 11,503 feet (3,506 m). The Los Angeles River , which is largely seasonal, is the primary drainage channel . It was straightened and lined in 51 miles (82 km) of concrete by
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#17327724859281416-744: Is a novel severe acute respiratory syndrome coronavirus. It was first isolated from three people with pneumonia connected to the cluster of acute respiratory illness cases in Wuhan. All structural features of the novel SARS-CoV-2 virus particle occur in related coronaviruses in nature, particularly in Rhinolophus sinicus (Chinese horseshoe bats). Outside the human body, the virus is destroyed by household soap which bursts its protective bubble . Hospital disinfectants, alcohols, heat, povidone-iodine , and ultraviolet -C (UV-C) irradiation are also effective disinfection methods for surfaces. SARS-CoV-2
1534-722: Is a common problem in this population. Although Serieys et al. 2014 find selection of immune genetics at several loci they do not demonstrate that this produces a real difference which helps the bobcats to survive future mange outbreaks . Los Angeles is subject to earthquakes because of its location on the Pacific Ring of Fire . The geologic instability has produced numerous faults , which cause approximately 10,000 earthquakes annually in Southern California, though most of them are too small to be felt. The strike-slip San Andreas Fault system, which sits at
1652-719: Is a sprawling metropolis of over 18.3 million residents. The majority of the city proper lies in a basin in Southern California adjacent to the Pacific Ocean in the west and extending partly through the Santa Monica Mountains and north into the San Fernando Valley , with the city bordering the San Gabriel Valley to its east. It covers about 469 square miles (1,210 km ), and is the county seat of Los Angeles County , which
1770-571: Is associated with COVID-19 and is reported in as many as 88% of symptomatic cases. Published data on the neuropathological changes related with COVID-19 have been limited and contentious, with neuropathological descriptions ranging from moderate to severe hemorrhagic and hypoxia phenotypes , thrombotic consequences, changes in acute disseminated encephalomyelitis (ADEM-type), encephalitis and meningitis . Many COVID-19 patients with co-morbidities have hypoxia and have been in intensive care for varying lengths of time, confounding interpretation of
1888-433: Is available, guidelines and recommendations for hypertensive patients remain. The effect of the virus on ACE2 cell surfaces leads to leukocytic infiltration, increased blood vessel permeability, alveolar wall permeability, as well as decreased secretion of lung surfactants. These effects cause the majority of the respiratory symptoms. However, the aggravation of local inflammation causes a cytokine storm eventually leading to
2006-402: Is because pregnant women with COVID‑19 appear to be more likely to develop respiratory and obstetric complications that can lead to miscarriage , premature delivery and intrauterine growth restriction . Fungal infections such as aspergillosis , candidiasis , cryptococcosis and mucormycosis have been recorded in patients recovering from COVID‑19. COVID‑19 is caused by infection with
2124-522: Is closely related to the original SARS-CoV . It is thought to have an animal ( zoonotic ) origin. Genetic analysis has revealed that the coronavirus genetically clusters with the genus Betacoronavirus , in subgenus Sarbecovirus (lineage B) together with two bat-derived strains. It is 96% identical at the whole genome level to other bat coronavirus samples (BatCov RaTG13 ). The structural proteins of SARS-CoV-2 include membrane glycoprotein (M), envelope protein (E), nucleocapsid protein (N), and
2242-452: Is complicated by rugged terrain, which has necessitated having different grids for each of the valleys that Los Angeles covers. Major streets are designed to move large volumes of traffic through many parts of the city, many of which are extremely long; Sepulveda Boulevard is 43 miles (69 km) long, while Foothill Boulevard is over 60 miles (97 km) long, reaching as far east as San Bernardino. Drivers in Los Angeles suffer from one of
2360-437: Is divided into many different districts and neighborhoods, some of which had been separately incorporated cities that eventually merged with Los Angeles. These neighborhoods were developed piecemeal, and are well-defined enough that the city has signage which marks nearly all of them. The city's street patterns generally follow a grid plan , with uniform block lengths and occasional roads that cut across blocks. However, this
2478-502: Is expected to continue to drop in the coming years because of aggressive steps to reduce it, which include electric and hybrid cars, improvements in mass transit , and other measures. The number of Stage 1 smog alerts in Los Angeles has declined from over 100 per year in the 1970s to almost zero in the new millennium. Despite improvement, the 2006 and 2007 annual reports of the American Lung Association ranked
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#17327724859282596-488: Is rich in native plant species partly because of its diversity of habitats, including beaches, wetlands , and mountains. The most prevalent plant communities are coastal sage scrub , chaparral shrubland, and riparian woodland . Native plants include: the California poppy , matilija poppy , toyon , Ceanothus , Chamise , Coast Live Oak , sycamore , willow and Giant Wildrye . Many of these native species, such as
2714-511: Is the most populous county in the United States with an estimated 9.86 million residents as of 2022 . It is the third-most visited city in the U.S. with over 2.7 million visitors as of 2023. The area that became Los Angeles was originally inhabited by the indigenous Tongva people and later claimed by Juan Rodríguez Cabrillo for Spain in 1542. The city was founded on September 4, 1781, under Spanish governor Felipe de Neve , on
2832-595: Is the cause of the bud release and the formation of the viral envelope. The N and E protein are accessory proteins that interfere with the host's immune response. Human angiotensin converting enzyme 2 (hACE2) is the host factor that SARS-CoV-2 virus targets causing COVID‑19. Theoretically, the usage of angiotensin receptor blockers (ARB) and ACE inhibitors upregulating ACE2 expression might increase morbidity with COVID‑19, though animal data suggest some potential protective effect of ARB; however no clinical studies have proven susceptibility or outcomes. Until further data
2950-469: Is the viral component that attaches to the host receptor via the ACE2 receptors. It includes two subunits: S1 and S2. Studies have shown that S1 domain induced IgG and IgA antibody levels at a much higher capacity. It is the focus spike proteins expression that are involved in many effective COVID‑19 vaccines. The M protein is the viral protein responsible for the transmembrane transport of nutrients. It
3068-413: The 1916 New York City Zoning Ordinance did. Second, the residential zones did not distinguish types of housing; they treated apartments, hotels, and detached-single-family housing equally. In 1910, Hollywood merged into Los Angeles, with 10 movie companies already operating in the city at the time. By 1921, more than 80 percent of the world's film industry was concentrated in L.A. The money generated by
3186-938: The Alpha variant (B.1.1.7, formerly called the UK variant), first found in London and Kent, the Beta variant (B.1.351, formerly called the South Africa variant), the Gamma variant (P.1, formerly called the Brazil variant), the Delta variant (B.1.617.2, formerly called the India variant), and the Omicron variant (B.1.1.529), which had spread to 57 countries as of 7 December. On December 19, 2023,
3304-805: The Army Corps of Engineers to act as a flood control channel. The river begins in the Canoga Park district of the city, flows east from the San Fernando Valley along the north edge of the Santa Monica Mountains, and turns south through the city center, flowing to its mouth in the Port of Long Beach at the Pacific Ocean. The smaller Ballona Creek flows into the Santa Monica Bay at Playa del Rey . Los Angeles
3422-547: The Hillside Stranglers murder cases in 1977–1978. In early 1984, the city surpassed Chicago in population, thus becoming the second largest city in the United States. In 1984, the city hosted the Summer Olympic Games for the second time . Despite being boycotted by 14 Communist countries , the 1984 Olympics became more financially successful than any previous, and the second Olympics to turn
3540-546: The Los Angeles sunflower , have become so rare as to be considered endangered. Mexican Fan Palms , Canary Island Palms , Queen Palms , Date Palms , and California Fan Palms are common in the Los Angeles area, although only the last is native to California, though still not native to the City of Los Angeles. Los Angeles has a number of official flora: The city has an urban population of bobcats ( Lynx rufus ). Mange
3658-593: The Mission San Gabriel Arcángel , the first mission in the area. On September 4, 1781, a group of 44 settlers known as " Los Pobladores " founded the pueblo (town) they called El Pueblo de Nuestra Señora la Reina de los Ángeles , 'The Town of Our Lady the Queen of the Angels';. The present-day city has the largest Roman Catholic archdiocese in the United States. Two-thirds of
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3776-616: The SARS-CoV-1 and MERS-CoV outbreaks, and consistent with other pandemics in human history. Social and environmental factors including climate change , natural ecosystem destruction and wildlife trade increased the likelihood of such zoonotic spillover . The disease quickly spread worldwide, resulting in the COVID-19 pandemic . The symptoms of COVID‑19 are variable but often include fever, fatigue, cough, breathing difficulties , loss of smell , and loss of taste . Symptoms may begin one to fourteen days after exposure to
3894-577: The Spanish Empire in 1542, while on an official military exploring expedition, as he was moving northward along the Pacific coast from earlier colonizing bases of New Spain in Central and South America. Gaspar de Portolà and Franciscan missionary Juan Crespí reached the present site of Los Angeles on August 2, 1769. In 1771, Franciscan friar Junípero Serra directed the building of
4012-588: The Spanish flu , Middle East respiratory syndrome , and Zika virus . In January 2020, the World Health Organization (WHO) recommended 2019-nCoV and 2019-nCoV acute respiratory disease as interim names for the virus and disease per 2015 guidance and international guidelines against using geographical locations or groups of people in disease and virus names to prevent social stigma . The official names COVID‑19 and SARS-CoV-2 were issued by
4130-577: The siege of Los Angeles where 150 Mexican militias fought the occupiers which eventually surrendered. Mexican rule ended during following the American Conquest of California , part of the larger Mexican-American War . Americans took control from the Californios after a series of battles, culminating with the signing of the Treaty of Cahuenga on January 13, 1847. The Mexican Cession
4248-482: The small intestine . The virus can cause acute myocardial injury and chronic damage to the cardiovascular system . An acute cardiac injury was found in 12% of infected people admitted to the hospital in Wuhan, China, and is more frequent in severe disease. Rates of cardiovascular symptoms are high, owing to the systemic inflammatory response and immune system disorders during disease progression, but acute myocardial injuries may also be related to ACE2 receptors in
4366-710: The spike protein (S). The M protein of SARS-CoV-2 is about 98% similar to the M protein of bat SARS-CoV, maintains around 98% homology with pangolin SARS-CoV, and has 90% homology with the M protein of SARS-CoV; whereas, the similarity is only around 38% with the M protein of MERS-CoV . The many thousands of SARS-CoV-2 variants are grouped into either clades or lineages . The WHO, in collaboration with partners, expert networks, national authorities, institutions and researchers, have established nomenclature systems for naming and tracking SARS-CoV-2 genetic lineages by GISAID , Nextstrain and Pango . The expert group convened by
4484-487: The 1890s brought rapid growth to the city. The city was further expanded with the completion of the Los Angeles Aqueduct in 1913, which delivers water from Eastern California . Los Angeles has a diverse economy with a broad range of industries. Despite a steep exodus of film and television production since the COVID-19 pandemic , Los Angeles is still one of the largest hubs of American film production ,
4602-671: The 1930s, / l ɔː s ˈ æ n dʒ əl ə s / has been most common. In 1934, the United States Board on Geographic Names decreed that this pronunciation be used by the federal government. This was also endorsed in 1952 by a "jury" appointed by Mayor Fletcher Bowron to devise an official pronunciation. Common pronunciations in the United Kingdom include / l ɒ s ˈ æ n dʒ ɪ l iː z , - l ɪ z , - l ɪ s / loss AN -jil-eez, -iz, -iss . Phonetician Jack Windsor Lewis described
4720-507: The 20th century, Los Angeles substantially reduced the amount of housing that could be built by drastically downzoning the city. In 1960, the city had a total zoned capacity for approximately 10 million people. By 1990, that capacity had fallen to 4.5 million as a result of policy decisions to ban housing through zoning. Racial tensions led to the Watts riots in 1965, resulting in 34 deaths and over 1,000 injuries. In 1969, California became
4838-817: The AIDS inmate population to more than 200 men," opposition decreased. The ward was constructed and received its first patients in May 1988, making it the second such AIDS ward in California (following one opened in 1984 at the California Medical Facility ). Shayne Allyn Ziska was a correctional officer at CIM "from January 1984 through October 2000." In 2004 he was arrested for helping the Nazi Lowriders (a white supremacist organization) "distribute drugs and assault inmates" inside CIM. In 2006, Ziska
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4956-548: The B.1 lineage. Several notable variants of SARS-CoV-2 emerged throughout 2020. Cluster 5 emerged among minks and mink farmers in Denmark . After strict quarantines and the slaughter of all the country's mink , the cluster was assessed to no longer be circulating among humans in Denmark as of 1 February 2021. As of December 2021 , there are five dominant variants of SARS-CoV-2 spreading among global populations:
5074-542: The CNS, possibly within an infected white blood cell. Research conducted when Alpha was the dominant variant has suggested COVID-19 may cause brain damage. Later research showed that all variants studied (including Omicron) killed brain cells, but the exact cells killed varied by variant. It is unknown if such damage is temporary or permanent. Observed individuals infected with COVID-19 (most with mild cases) experienced an additional 0.2% to 2% of brain tissue lost in regions of
5192-562: The COVID-19 infection may have different symptoms, and their symptoms may change over time. Three common clusters of symptoms have been identified: a respiratory symptom cluster with cough, sputum , shortness of breath , and fever; a musculoskeletal symptom cluster with muscle and joint pain, headache, and fatigue; and a cluster of digestive symptoms with abdominal pain, vomiting, and diarrhea. In people without prior ear, nose, or throat disorders, loss of taste combined with loss of smell
5310-507: The City of Los Angeles from selling or providing water from the aqueduct to any area outside its borders, many adjacent cities and communities felt compelled to join Los Angeles. Los Angeles created the first municipal zoning ordinance in the United States. On September 14, 1908, the Los Angeles City Council promulgated residential and industrial land use zones. The new ordinance established three residential zones of
5428-629: The Los Angeles area include the 1933 Long Beach , 1971 San Fernando , 1987 Whittier Narrows , and the 1994 Northridge events. All but a few are of low intensity and are not felt. The USGS has released the UCERF California earthquake forecast , which models earthquake occurrence in California. Parts of the city are also vulnerable to tsunamis ; harbor areas were damaged by waves from Aleutian Islands earthquake in 1946, Valdivia earthquake in 1960, Alaska earthquake in 1964, Chile earthquake in 2010 and Japan earthquake in 2011. The city
5546-502: The Los Angeles area was the headquarters of six of the country's major aircraft manufacturers ( Douglas Aircraft Company , Hughes Aircraft , Lockheed , North American Aviation , Northrop Corporation , and Vultee ). During the war, more aircraft were produced in one year than in all the pre-war years since the Wright brothers flew the first airplane in 1903, combined. Manufacturing in Los Angeles skyrocketed, and as William S. Knudsen , of
5664-685: The Los Angeles/Long Beach port complex, Los Angeles suffers from air pollution in the form of smog. The Los Angeles Basin and the San Fernando Valley are susceptible to atmospheric inversion , which holds in the exhausts from road vehicles, airplanes, locomotives, shipping, manufacturing, and other sources. The smog season lasts from approximately May to October. While other large cities rely on rain to clear smog, Los Angeles gets only 15 inches (380 mm) of rain each year: pollution accumulates over many consecutive days. Issues of air quality in Los Angeles and other major cities led to
5782-489: The Mexican or ( New Spain ) settlers were mestizo or mulatto , a mixture of African, indigenous and European ancestry. The settlement remained a small ranch town for decades, but by 1820, the population had increased to about 650 residents. Today, the pueblo is commemorated in the historic district of Los Angeles Pueblo Plaza and Olvera Street , the oldest part of Los Angeles. New Spain achieved its independence from
5900-523: The National Defense Advisory Commission put it, "We won because we smothered the enemy in an avalanche of production, the like of which he had never seen, nor dreamed possible." After the end of World War II Los Angeles grew more rapidly than ever, sprawling into the San Fernando Valley . The expansion of the state owned Interstate Highway System during the 1950s and 1960s helped propel suburban growth and signaled
6018-571: The Queen of the Angels'. The original name of the settlement is disputed; the Guinness Book of World Records rendered it as "El Pueblo de Nuestra Señora la Reina de los Ángeles del Río Porciúncula "; other sources have shortened or alternate versions of the longer name. The local English pronunciation of the name of the city has varied over time. A 1953 article in the journal of the American Name Society asserts that
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#17327724859286136-696: The San Fernando Valley. Other hilly parts of Los Angeles include the Mt. Washington area north of Downtown, eastern parts such as Boyle Heights , the Crenshaw district around the Baldwin Hills , and the San Pedro district. Surrounding the city are much higher mountains. Immediately to the north lie the San Gabriel Mountains , which is a popular recreation area for Angelenos. Its high point
6254-527: The Southern Californian coast, is subject to a late spring/early summer weather phenomenon called " June Gloom ". This involves overcast or foggy skies in the morning that yield to sun by early afternoon. More recently, statewide droughts in California have further strained the city's water security . Downtown Los Angeles averages 14.67 in (373 mm) of precipitation annually, mainly occurring between November and March, generally in
6372-475: The Spanish Empire in 1821, and the pueblo now existed within the new Mexican Republic . During Mexican rule, Governor Pío Pico made Los Angeles the regional capital of Alta California . By this time, the new republic introduced more secularization acts within the Los Angeles region. In 1846, during the wider Mexican-American war , marines from the United States occupied the pueblo. This resulted in
6490-475: The WHO declared that another distinctive variant, JN.1, had emerged as a "variant of interest". Though the WHO expected an increase in cases globally, particularly for countries entering winter, the overall global health risk was considered low. The SARS-CoV-2 virus can infect a wide range of cells and systems of the body. COVID‑19 is most known for affecting the upper respiratory tract (sinuses, nose, and throat) and
6608-759: The WHO on 11 February 2020 with COVID-19 being shorthand for "coronavirus disease 2019". The WHO additionally uses "the COVID‑19 virus" and "the virus responsible for COVID‑19" in public communications. The symptoms of COVID-19 are variable depending on the type of variant contracted, ranging from mild symptoms to a potentially fatal illness. Common symptoms include coughing , fever , loss of smell (anosmia) and taste (ageusia), with less common ones including headaches , nasal congestion and runny nose , muscle pain , sore throat , diarrhea , eye irritation , and toes swelling or turning purple, and in moderate to severe cases, breathing difficulties . People with
6726-551: The WHO recommended the labelling of variants using letters of the Greek alphabet , for example, Alpha , Beta , Delta , and Gamma , giving the justification that they "will be easier and more practical to discussed by non-scientific audiences". Nextstrain divides the variants into five clades (19A, 19B, 20A, 20B, and 20C), while GISAID divides them into seven (L, O, V, S, G, GH, and GR). The Pango tool groups variants into lineages , with many circulating lineages being classed under
6844-769: The birthplace of the Internet, as the first ARPANET transmission was sent from the University of California, Los Angeles (UCLA) to the Stanford Research Institute in Menlo Park . In 1973, Tom Bradley was elected as the city's first African American mayor, serving for five terms until retiring in 1993. Other events in the city during the 1970s included the Symbionese Liberation Army 's South Central standoff in 1974 and
6962-632: The boundary between the Pacific Plate and the North American Plate , passes through the Los Angeles metropolitan area. The segment of the fault passing through Southern California experiences a major earthquake roughly every 110 to 140 years, and seismologists have warned about the next "big one", as the last major earthquake was the 1857 Fort Tejon earthquake . The Los Angeles basin and metropolitan area are also at risk from blind thrust earthquakes . Major earthquakes that have hit
7080-485: The boundary of a Mediterranean climate ( Köppen : Csb on the coast, Csa otherwise). Daytime temperatures are generally temperate all year round. In winter, they average around 68 °F (20 °C). Autumn months tend to be hot, with major heat waves a common occurrence in September and October, while the spring months tend to be cooler and experience more precipitation. Los Angeles has plenty of sunshine throughout
7198-515: The brain connected to the sense of smell compared with uninfected individuals, and the overall effect on the brain was equivalent on average to at least one extra year of normal ageing; infected individuals also scored lower on several cognitive tests. All effects were more pronounced among older ages. The virus also affects gastrointestinal organs as ACE2 is abundantly expressed in the glandular cells of gastric , duodenal and rectal epithelium as well as endothelial cells and enterocytes of
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#17327724859287316-591: The brain found as complications leading to death in people infected with COVID‑19. Infection may initiate a chain of vasoconstrictive responses within the body, including pulmonary vasoconstriction – a possible mechanism in which oxygenation decreases during pneumonia. Furthermore, damage of arterioles and capillaries was found in brain tissue samples of people who died from COVID‑19. COVID‑19 may also cause substantial structural changes to blood cells , sometimes persisting for months after hospital discharge. A low level of blood lymphocytess may result from
7434-428: The brains of those who have died from COVID‑19, but these results need to be confirmed. While virus has been detected in cerebrospinal fluid of autopsies, the exact mechanism by which it invades the CNS remains unclear and may first involve invasion of peripheral nerves given the low levels of ACE2 in the brain. The virus may also enter the bloodstream from the lungs and cross the blood–brain barrier to gain access to
7552-404: The city as the most polluted in the country with short-term particle pollution and year-round particle pollution. In 2008, the city was ranked the second most polluted and again had the highest year-round particulate pollution. The city met its goal of providing 20 percent of the city's power from renewable sources in 2010. The American Lung Association's 2013 survey ranks the metro area as having
7670-537: The city is 342 miles (550 km). Los Angeles is both flat and hilly. The highest point in the city proper is Mount Lukens at 5,074 ft (1,547 m), located in the foothills of the San Gabriel Mountains at the north extent of the Crescenta Valley . The eastern end of the Santa Monica Mountains stretches from Downtown to the Pacific Ocean and separates the Los Angeles Basin from
7788-459: The city limits as of 2023 , it is the second-most populous city in the United States, behind only New York City ; it is also the commercial, financial and cultural center of Southern California . Los Angeles has an ethnically and culturally diverse population, and is the principal city of a metropolitan area of 12.8 million people (2023). Greater Los Angeles , which includes the Los Angeles and Riverside–San Bernardino metropolitan areas,
7906-560: The city, causing $ 12.5 billion in damage and 72 deaths. The century ended with the Rampart scandal , one of the most extensive documented cases of police misconduct in American history. In 2002, Mayor James Hahn led the campaign against secession, resulting in voters defeating efforts by the San Fernando Valley and Hollywood to secede from the city. In 2022 , Karen Bass became the city's first female mayor , making Los Angeles
8024-497: The city. However, between 1908 and 1915, the Los Angeles City Council created various exceptions to the broad proscriptions that applied to these three residential zones, and as a consequence, some industrial uses emerged within them. There are two differences between the 1908 Residence District Ordinance and later zoning laws in the United States. First, the 1908 laws did not establish a comprehensive zoning map as
8142-409: The clear jelly liquid found in lung autopsies of people who died of COVID-19. One possibility addressed in medical research is that hyuralonic acid (HA) could be the leading factor for this observation of the clear jelly liquid found in the lungs, in what could be hyuralonic storm, in conjunction with cytokine storm . One common symptom, loss of smell, results from infection of the support cells of
8260-409: The country's largest oil producer, accounting for about one-quarter of the world's petroleum output. By 1900, the population had grown to more than 102,000, putting pressure on the city's water supply . The completion of the Los Angeles Aqueduct in 1913, under the supervision of William Mulholland , ensured the continued growth of the city. Because of clauses in the city's charter that prevented
8378-406: The data. Of people who show symptoms, 81% develop only mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging) that require hospitalization, and 5% of patients develop critical symptoms ( respiratory failure , septic shock , or multiorgan dysfunction ) requiring ICU admission. At least a third of
8496-477: The demise of the city's privately owned electrified rail system , once the world's largest. As a consequence of World War II, suburban growth, and population density, many amusement parks were built and operated in this area. An example is Beverly Park , which was located at the corner of Beverly Boulevard and La Cienega before being closed and substituted by the Beverly Center . In the second half of
8614-617: The difference between the average daily low and the average daily high is over 30 °F (17 °C). The average annual temperature of the sea is 63 °F (17 °C), from 58 °F (14 °C) in January to 68 °F (20 °C) in August. Hours of sunshine total more than 3,000 per year, from an average of 7 hours of sunshine per day in December to an average of 12 in July. Due to
8732-524: The era of Spanish colonization). The historic center of Tongva power in the region was the settlement of Yaanga ( Tongva : Iyáangẚ ), meaning "place of the poison oak ", which would one day be the site where the Spanish founded the Pueblo de Los Ángeles . Iyáangẚ has also been translated as "the valley of smoke". Maritime explorer Juan Rodríguez Cabrillo claimed the area of southern California for
8850-721: The expression of ACE-2, thereby facilitating the SARS-Cov2 virus to enter cells and to replicate. A competition of negative feedback loops (via protective effects of interferon alpha) and positive feedback loops (via upregulation of ACE-2) is assumed to determine the fate of patients suffering from COVID-19. Additionally, people with COVID‑19 and acute respiratory distress syndrome (ARDS) have classical serum biomarkers of CRS, including elevated C-reactive protein (CRP), lactate dehydrogenase (LDH), D-dimer , and ferritin . Systemic inflammation results in vasodilation , allowing inflammatory lymphocytic and monocytic infiltration of
8968-428: The eyes, nose, or mouth. The risk is highest when people are in close proximity, but small airborne particles containing the virus can remain suspended in the air and travel over longer distances, particularly indoors. Transmission can also occur when people touch their eyes, nose or mouth after touching surfaces or objects that have been contaminated by the virus. People remain contagious for up to 20 days and can spread
9086-525: The face. While drugs have been developed to inhibit the virus, the primary treatment is still symptomatic , managing the disease through supportive care , isolation , and experimental measures . During the initial outbreak in Wuhan , the virus and disease were commonly referred to as "coronavirus" and "Wuhan coronavirus", with the disease sometimes called "Wuhan pneumonia". In the past, many diseases have been named after geographical locations, such as
9204-598: The first major minimum security institution built and operated in the United States." It was the fourth state prison built in California (after San Quentin State Prison , Folsom State Prison , and the original California Institution for Women at Tehachapi ). Since the California Correctional Institution replaced the original California Institution for Women at Tehachapi, CIM is now the third-oldest California state prison. In 1970,
9322-407: The form of moderate rain showers, but sometimes as heavy rainfall during winter storms. Rainfall is usually higher in the hills and coastal slopes of the mountains because of orographic uplift. Summer days are usually rainless. Rarely, an incursion of moist air from the south or east can bring brief thunderstorms in late summer, especially to the mountains. The coast gets slightly less rainfall, while
9440-523: The heart. ACE2 receptors are highly expressed in the heart and are involved in heart function. A high incidence of thrombosis and venous thromboembolism occurs in people transferred to intensive care units with COVID‑19 infections, and may be related to poor prognosis. Blood vessel dysfunction and clot formation (as suggested by high D-dimer levels caused by blood clots) may have a significant role in mortality, incidents of clots leading to pulmonary embolisms , and ischaemic events (strokes) within
9558-503: The host cell. Following viral entry, COVID‑19 infects the ciliated epithelium of the nasopharynx and upper airways. Autopsies of people who died of COVID‑19 have found diffuse alveolar damage , and lymphocyte-containing inflammatory infiltrates within the lung. From the CT scans of COVID-19 infected lungs, white patches were observed containing fluid known as ground-glass opacity (GGO) or simply ground glass. This tended to correlate with
9676-565: The industry kept the city insulated from much of the economic loss suffered by the rest of the country during the Great Depression . By 1930, the population surpassed one million. In 1932, the city hosted the Summer Olympics . During World War II Los Angeles was a major center of wartime manufacturing, such as shipbuilding and aircraft. Calship built hundreds of Liberty Ships and Victory Ships on Terminal Island, and
9794-528: The infection, children may develop paediatric multisystem inflammatory syndrome , which has symptoms similar to Kawasaki disease , which can be fatal. In very rare cases, acute encephalopathy can occur, and it can be considered in those who have been diagnosed with COVID‑19 and have an altered mental status. According to the US Centers for Disease Control and Prevention , pregnant women are at increased risk of becoming seriously ill from COVID‑19. This
9912-521: The inland and mountain areas get considerably more. Years of average rainfall are rare. The usual pattern is a year-to-year variability, with a short string of dry years of 5–10 in (130–250 mm) rainfall, followed by one or two wet years with more than 20 in (510 mm). Wet years are usually associated with warm water El Niño conditions in the Pacific, dry years with cooler water La Niña episodes. A series of rainy days can bring floods to
10030-500: The inmate's lengthy stay at CIM, the inmate's access to a weapon, and the officer's lack of a protective vest. In the aftermath of the Gonzalez murder, CIM instituted reforms. The California Department of Corrections and Rehabilitation in July 2007 agreed to pay $ 1.2 million to settle a lawsuit by Gonzalez's family. In 2005 and 2007, the state of California proposed building hundreds of new units for mentally ill inmates at CIM and at
10148-575: The largest U.S. city to have ever had a woman as mayor. Los Angeles will host the 2028 Summer Olympics and Paralympic Games , making Los Angeles the third city to host the Olympics three times. The city of Los Angeles covers a total area of 502.7 square miles (1,302 km ), comprising 468.7 square miles (1,214 km ) of land and 34.0 square miles (88 km ) of water. The city extends for 44 miles (71 km) from north to south and for 29 miles (47 km) from east to west. The perimeter of
10266-454: The lower respiratory tract (windpipe and lungs). The lungs are the organs most affected by COVID‑19 because the virus accesses host cells via the receptor for the enzyme angiotensin-converting enzyme 2 (ACE2), which is most abundant on the surface of type II alveolar cells of the lungs. The virus uses a special surface glycoprotein called a " spike " to connect to the ACE2 receptor and enter
10384-490: The lowest is 28 °F (−2 °C), on January 4, 1949. Within the City of Los Angeles, the highest temperature ever officially recorded is 121 °F (49 °C), on September 6, 2020, at the weather station at Pierce College in the San Fernando Valley neighborhood of Woodland Hills . During autumn and winter, Santa Ana winds sometimes bring much warmer and drier conditions to Los Angeles, and raise wildfire risk. Owing to geography, heavy reliance on automobiles, and
10502-505: The lowlands and mudslides to the hills, especially after wildfires have denuded the slopes. Both freezing temperatures and snowfall are extremely rare in the city basin and along the coast, with the last occurrence of a 32 °F (0 °C) reading at the downtown station being January 29, 1979; freezing temperatures occur nearly every year in valley locations while the mountains within city limits typically receive snowfall every winter. The greatest snowfall recorded in downtown Los Angeles
10620-409: The lung and the heart. In particular, pathogenic GM-CSF-secreting T cells were shown to correlate with the recruitment of inflammatory IL-6-secreting monocytes and severe lung pathology in people with COVID‑19. Lymphocytic infiltrates have also been reported at autopsy. Multiple viral and host factors affect the pathogenesis of the virus. The S-protein , otherwise known as the spike protein,
10738-447: The moment a person first becomes infected and the appearance of the first symptoms. The median delay for COVID-19 is four to five days possibly being infectious on 1–4 of those days. Most symptomatic people experience symptoms within two to seven days after exposure, and almost all will experience at least one symptom within 12 days. Most people recover from the acute phase of the disease. However, some people continue to experience
10856-530: The most common one, / l ɒ s ˈ æ n dʒ ɪ l iː z / , as a spelling pronunciation based on analogy to Greek words ending in -es , "reflecting a time when the classics were familiar if Spanish was not". The settlement of Indigenous Californians in the modern Los Angeles Basin and the San Fernando Valley was dominated by the Tongva (now also known as the Gabrieleño since
10974-546: The mountainous terrain of the surrounding region, the Los Angeles area contains a large number of distinct microclimates , causing extreme variations in temperature in close physical proximity to each other. For example, the average July maximum temperature at the Santa Monica Pier is 70 °F (21 °C) whereas it is 95 °F (35 °C) in Canoga Park, 15 miles (24 km) away. The city, like much of
11092-483: The name's pronunciation with a hard g ( / ɡ / ), reported that there were at least 12 pronunciation variants. In the early 1900s, the Los Angeles Times advocated for pronouncing it Loce AHNG-hayl-ais ( / l oʊ s ˈ ɑː ŋ h eɪ l eɪ s / ), approximating Spanish [los ˈaŋxeles] , by printing the respelling under its masthead for several years. This did not find favor. Since
11210-468: The nation's worst smog, and fourth in both short-term and year-round pollution amounts. COVID-19 Coronavirus disease 2019 ( COVID-19 ) is a contagious disease caused by the coronavirus SARS-CoV-2 . The first known case was identified in Wuhan , China, in December 2019. Most scientists believe the SARS-CoV-2 virus entered into human populations through natural zoonosis , similar to
11328-561: The nearby California Institution for Women ; local officials opposed such plans. A "general acute-care hospital at CIM" had received a license to operate in 1984, but in March 2006 the hospital operating room was closed and in July 2007 the plan was "to relinquish the license" because the facility was not functioning as a hospital. On August 8, 2009, a prison riot broke out at CIM during which over 250 inmates were injured, and which ultimately took more than twelve hours to put down. The cause of
11446-480: The olfactory epithelium , with subsequent damage to the olfactory neurons . The involvement of both the central and peripheral nervous system in COVID‑19 has been reported in many medical publications. It is clear that many people with COVID-19 exhibit neurological or mental health issues . The virus is not detected in the central nervous system (CNS) of the majority of COVID-19 patients with neurological issues . However, SARS-CoV-2 has been detected at low levels in
11564-514: The passage of early national environmental legislation, including the Clean Air Act . When the act was passed, California was unable to create a State Implementation Plan that would enable it to meet the new air quality standards, largely because of the level of pollution in Los Angeles generated by older vehicles. More recently, the state of California has led the nation in working to limit pollution by mandating low-emission vehicles . Smog
11682-488: The peak viral load in upper respiratory tract samples occurs close to the time of symptom onset and declines after the first week after symptoms begin. Current evidence suggests a duration of viral shedding and the period of infectiousness of up to ten days following symptom onset for people with mild to moderate COVID-19, and up to 20 days for persons with severe COVID-19, including immunocompromised people. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
11800-411: The people who are infected with the virus do not develop noticeable symptoms at any point in time. These asymptomatic carriers tend not to get tested and can still spread the disease. Other infected people will develop symptoms later (called "pre-symptomatic") or have very mild symptoms and can also spread the virus. As is common with infections, there is a delay, or incubation period , between
11918-423: The pronunciation / l ɔː s ˈ æ n dʒ əl ə s / lawss AN -jəl-əs was established following the 1850 incorporation of the city and that since the 1880s the pronunciation / l oʊ s ˈ æ ŋ ɡ əl ə s / lohss ANG -gəl-əs emerged from a trend in California to give places Spanish, or Spanish-sounding, names and pronunciations. In 1908, librarian Charles Fletcher Lummis , who argued for
12036-416: The respiratory tract, people with severe COVID‑19 have symptoms of systemic hyperinflammation. Clinical laboratory findings of elevated IL‑2 , IL‑6 , IL‑7 , as well as the following suggest an underlying immunopathology: Interferon alpha plays a complex, Janus-faced role in the pathogenesis of COVID-19. Although it promotes the elimination of virus-infected cells, it also upregulates
12154-563: The rest of the surrounding landscape. Most construction is done in separate units, rather than wall-to-wall . However, Downtown Los Angeles itself has many buildings over 30 stories, with fourteen over 50 stories, and two over 70 stories, the tallest of which is the Wilshire Grand Center . Los Angeles has a two-season semi-arid climate ( Köppen : BSh ) with dry summers and very mild winters, but it receives more annual precipitation than most semi-arid climates, narrowly missing
12272-403: The riot is under investigation. The riot broke out at 8:20 p.m. Although other races were involved the riot was mainly between Hispanic inmates and African American inmates. The prison's damages were severe, bathroom sinks ripped off the walls, fires broke out, and 50 inmates were taken to nearby hospitals. The riot caused a lockdown of the prison and six others in the area. In February 2010,
12390-859: The risk of long COVID includes staying up to date on the most recent COVID-19 vaccine, practicing good hygiene, maintaining clean indoor air, and physical distancing from people infected with a respiratory virus. Complications may include pneumonia , acute respiratory distress syndrome (ARDS), multi-organ failure , septic shock , and death. Cardiovascular complications may include heart failure, arrhythmias (including atrial fibrillation ), heart inflammation , thrombosis , particularly venous thromboembolism , and endothelial cell injury and dysfunction. Approximately 20–30% of people who present with COVID‑19 have elevated liver enzymes , reflecting liver injury. Neurologic manifestations include seizure , stroke, encephalitis , and Guillain–Barré syndrome (which includes loss of motor functions ). Following
12508-650: The village of Yaanga . It became a part of the First Mexican Empire in 1821 following the Mexican War of Independence . In 1848, at the end of the Mexican–American War , Los Angeles and the rest of California were purchased as part of the Treaty of Guadalupe Hidalgo and became part of the United States. Los Angeles was incorporated as a municipality on April 4, 1850, five months before California achieved statehood . The discovery of oil in
12626-516: The virus acting through ACE2-related entry into lymphocytes. Another common cause of death is complications related to the kidneys . Early reports show that up to 30% of hospitalised patients both in China and in New York have experienced some injury to their kidneys, including some persons with no previous kidney problems. Although SARS-CoV-2 has a tropism for ACE2-expressing epithelial cells of
12744-752: The virus even if they do not develop symptoms. Testing methods for COVID-19 to detect the virus's nucleic acid include real-time reverse transcription polymerase chain reaction (RT‑PCR), transcription-mediated amplification , and reverse transcription loop-mediated isothermal amplification (RT‑LAMP) from a nasopharyngeal swab . Several COVID-19 vaccines have been approved and distributed in various countries, many of which have initiated mass vaccination campaigns . Other preventive measures include physical or social distancing , quarantining , ventilation of indoor spaces, use of face masks or coverings in public, covering coughs and sneezes, hand washing , and keeping unwashed hands away from
12862-509: The virus is carried out through virus-laden fluid particles, or droplets, which are created in the respiratory tract, and they are expelled by the mouth and the nose. There are three types of transmission: "droplet" and "contact", which are associated with large droplets, and "airborne", which is associated with small droplets. If the droplets are above a certain critical size, they settle faster than they evaporate , and therefore they contaminate surfaces surrounding them. Droplets that are below
12980-464: The virus. At least a third of people who are infected do not develop noticeable symptoms . Of those who develop symptoms noticeable enough to be classified as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia ), while 14% develop severe symptoms ( dyspnea , hypoxia , or more than 50% lung involvement on imaging), and 5% develop critical symptoms ( respiratory failure , shock , or multiorgan dysfunction ). Older people are at
13098-512: The world's largest by revenue; the city is an important site in the history of film . It also has one of the busiest container ports in the Americas. In 2018, the Los Angeles metropolitan area had a gross metropolitan product of over $ 1.0 trillion, making it the city with the third-largest GDP in the world, after New York and Tokyo . Los Angeles hosted the Summer Olympics in 1932 and 1984 , and will also host in 2028 . Despite
13216-635: The worst rush hour periods in the world, according to an annual traffic index by navigation system maker, TomTom . LA drivers spend an additional 92 hours in traffic each year. During the peak rush hour, there is 80% congestion, according to the index. Los Angeles is often characterized by the presence of low-rise buildings, in contrast to New York City. Outside of a few centers such as Downtown , Warner Center , Century City , Koreatown , Miracle Mile , Hollywood, and Westwood , skyscrapers and high-rise buildings are not common in Los Angeles. The few skyscrapers built outside of those areas often stand out above
13334-582: The year, with an average of only 35 days with measurable precipitation annually. Temperatures in the coastal basin exceed 90 °F (32 °C) on a dozen or so days in the year, from one day a month in April, May, June and November to three days a month in July, August, October and to five days in September. Temperatures in the San Fernando and San Gabriel Valleys are considerably warmer. Temperatures are subject to substantial daily swings; in inland areas
13452-417: The youth facility Heman G. Stark Youth Correctional Facility was closed. California authorities indicated they would incorporate the facility into CIM. As of 2017, it remains empty except for an apartment-style housing unit for CDCR employees. In August 2020, CIM's role as a reception center ended, and it was one of three former reception centers in California that were reclassified. As of December 4, 2020 it
13570-502: Was 2.0 inches (5 cm) on January 15, 1932. While the most recent snowfall occurred in February 2019, the first snowfall since 1962, with snow falling in areas adjacent to Los Angeles as recently as January 2021. Brief, localized instances of hail can occur on rare occasions, but are more common than snowfall. At the official downtown station, the highest recorded temperature is 113 °F (45 °C) on September 27, 2010, while
13688-466: Was convicted "on charges of conspiracy, civil-rights violations and violent crime in aid of racketeering" and sentenced to 17 years and was released in 2021. Correctional Officer Manuel A. Gonzalez Jr. was stabbed to death in CIM in 2005. Factors that may have contributed to the killing were prison overcrowding , understaffing, a failure to segregate the inmate in question due to a history of violent behavior,
13806-502: Was formalized in the Treaty of Guadalupe Hidalgo in 1848, which ceded Los Angeles and the rest of Alta California to the United States. Railroads arrived with the completion of the transcontinental Southern Pacific line from New Orleans to Los Angeles in 1876 and the Santa Fe Railroad in 1885. Petroleum was discovered in the city and surrounding area in 1892, and by 1923, the discoveries had helped California become
13924-401: Was reported that the COVID-19 virus had killed 27 inmates at CIM, and the virus had infected 172 staff with 789 recovered cases 18 active cases and 1036 inmates had been infected and had since recovered. Los Angeles Los Angeles , often referred to by its initials L.A. , is the most populous city in the U.S. state of California . With an estimated 3,820,914 residents within
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