201-541: British victory [REDACTED] British Empire The Australian frontier wars were the violent conflicts between Indigenous Australians (including both Aboriginal Australians and Torres Strait Islanders ) and mostly British settlers during the colonial period of Australia . The first conflict took place several months after the landing of the First Fleet in January 1788, and the last conflicts occurred in
402-828: A fair trial . The English monarchs, through inheritance of substantial territories in France and claims to the French crown, were also heavily involved in conflicts in France, most notably the Hundred Years' War , while the Kings of Scots were in an alliance with the French during this period. Early modern Britain saw religious conflict resulting from the Reformation and the introduction of Protestant state churches in each country. The English Reformation ushered in political, constitutional, social and cultural change in
603-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether
804-521: A subpolar oceanic climate . Higher elevations in Scotland experience a continental subarctic climate and the mountains experience a tundra climate . The prevailing wind is from the southwest and bears frequent spells of mild and wet weather from the Atlantic Ocean, although the eastern parts are mostly sheltered from this wind. Since the majority of the rain falls over the western regions,
1005-604: A welfare state was established, and a comprehensive, publicly funded healthcare system, the National Health Service , was created. The rise of nationalism in the colonies coincided with Britain's much-diminished economic position, so that a policy of decolonisation was unavoidable. Independence was granted to India and Pakistan in 1947. Over the next three decades, most colonies of the British Empire gained their independence, and many became members of
1206-494: A Magistrate who proceeded in different directions in towards the interior of the Country ... This system of keeping these unfortunate People in a constant state of alarm soon brought them to a sense of their Duty, and ... Saturday their great and most warlike Chieftain has been with me to receive his pardon and that He, with most of His Tribe, attended the annual conference held here on the 28th Novr.... Brisbane also established
1407-473: A bible. There was also great difficulty in translation. The intentions of those establishing and leading the new colony soon came into conflict with the fears of Aboriginal people and the new settlers. "In South Australia, as across Australia's other colonies, the failure to adequately deal with Aboriginal rights to land was fundamental to the violence that followed." Soon after the colony was established, large numbers of sheep and cattle were brought overland from
1608-532: A brief statement that explicitly stated how the native population should be treated. He said in part: It is also, at this time especially, my duty to apprize the Colonists of my resolution, to take every lawful means of extending the same protection to the native population as to the rest of His Majesty's Subjects, and of my firm determination to punish with exemplary severity, all acts of violence or injustice which may in any manner be practiced or attempted against
1809-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but
2010-415: A discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on the distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach
2211-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox
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#17327724526602412-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major
2613-408: A few warriors had been killed or wounded, due to the need to ensure the ongoing survival of the groups. Such battles were usually fought to settle grievances between groups, and could take some time to prepare. Ritual trials involved the application of customary law to one or more members of a group who had committed a crime such as murder or assault. Weapons were used to inflict injury, and the criminal
2814-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in
3015-816: A land border with the Republic of Ireland ; otherwise, the United Kingdom is surrounded by the Atlantic Ocean , the North Sea , the English Channel , the Celtic Sea , and the Irish Sea . The United Kingdom had an estimated population of over 68.2 million people in 2023. The capital and largest city of both England and the United Kingdom is London , whose wider metropolitan area is
3216-399: A leading role in the movement to abolish slavery worldwide through the blockade of Africa and pressing other nations to end their trade with a series of treaties. In 1800 the parliaments of Great Britain and Ireland each passed an Act of Union, uniting the two kingdoms and creating the United Kingdom of Great Britain and Ireland on 1 January 1801. After the defeat of France at the end of
3417-611: A low rate of fire, whilst suffering from a high rate of failure and were only accurate within 50 metres (160 ft). These deficiencies may have given the Aboriginal residents some advantages, allowing them to move in close and engage with spears or clubs . However, by 1850 significant advances in firearms gave the Europeans a distinct advantage, with the six-shot Colt revolver , the Snider single shot breech-loading rifle and later
3618-428: A number of indiscriminate massacres . European activities provoking significant conflict included pastoral squatting and gold rushes . Opinions differ on whether to depict the conflict as one-sided and mainly perpetrated by Europeans on Indigenous Australians or not. Although tens of thousands more Indigenous Australians died than Europeans, some cases of mass killing were not massacres but quasi-military defeats, and
3819-800: A policy of splendid isolation in Europe, and attempted to contain Russian influence in Afghanistan and Persia , in what came to be known as the Great Game . During this time, Canada , Australia and New Zealand were granted self-governing dominion status. At the turn of the century, Britain's industrial dominance became challenged by the German Empire and the United States . The Edwardian era saw social reform and home rule for Ireland become important domestic issues, while
4020-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on
4221-470: A pre-contact Indigenous population density more than double that of New South Wales, at least six times that of Victoria, and at least twenty times that of Tasmania. Equally, there are signs that the population density of Indigenous Australia was comparatively higher in the north-eastern sections of New South Wales, and along the northern coast from the Gulf of Carpentaria and westward including certain sections of
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#17327724526604422-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with
4623-644: A reservation which had been established at Flinders Island . The first British settlement in Western Australia was established by a detachment of soldiers at Albany in 1826. Relations between the garrison and the local Minang people were generally good. Open conflict between people of the Noongar nation and European settlers broke out in Western Australia in the 1830s as the Swan River Colony expanded from Perth . The Pinjarra massacre ,
4824-507: A result of a shortage of workers in the 1950s, the government encouraged immigration from Commonwealth countries . In the following decades, the UK became a more multi-ethnic society. Despite rising living standards in the late 1950s and 1960s, the UK's economic performance was less successful than many of its main competitors such as France, West Germany and Japan. The UK was the first democratic nation to lower its voting age to 18 in 1969. In
5025-811: A series of connected wars (including the English Civil War ) which led to the temporary overthrow of the monarchy, with the execution of King Charles I , and the establishment of the short-lived unitary republic of the Commonwealth of England , Scotland and Ireland. Although the monarchy was restored , the Interregnum along with the Glorious Revolution of 1688 and the subsequent Bill of Rights 1689 in England and Claim of Right Act 1689 in Scotland ensured that, unlike much of
5226-438: A servant of the household, as was the response permitted under Noongar law. In 1832 Yagan and two others were arrested and sentenced to death, but settler Robert Menli Lyon argued that Yagan was defending his land from invasion and therefore should be treated as a prisoner of war. The argument was successful and the three men were exiled to Carnac Island under the supervision of Lyon and two soldiers. The group later escaped from
5427-634: A settlement in Van Diemen's Land (modern Tasmania ) in 1803. Relations with the local Indigenous people were generally peaceful until the mid-1820s when pastoral expansion caused conflict over land. This led to sustained frontier warfare (the " Black War "), and in some districts farmers were forced to fortify their houses. Over 50 British were killed between 1828 and 1830 in what was the "most successful Aboriginal resistance in Australia's history". In 1830 Lieutenant-Governor Arthur attempted to end
5628-424: A significant influence over the tactics used during traditional Aboriginal warfare. The limitations of spears and clubs meant that surprise was paramount during raids for women and revenge attacks, and encouraged ambushing and night attacks. These tactics were offset by counter-measures such as regularly changing campsites, being prepared to extinguish camp-fires at short notice, and posting parties of warriors to cover
5829-525: A single spear was thrown toward the British party, which "happily hurt nobody". This then caused Cook to order "the third musket with small-shots" to be fired, "upon which one of them threw another lance and both immediately ran away". Some historians have argued that under prevailing European legal doctrine such land was deemed terra nullius or land belonging to nobody or land "empty of inhabitants" (as defined by Emerich de Vattel ). However, terra nullius
6030-478: A small landing party fired on a group of the local Dharawal nation who had sought to prevent them from landing at the foot of their camp at Botany Bay , described by Cook as "a small village". Two Dharawal men made threatening gestures and threw a stone at Cook's party. Cook then ordered "a musket to be fired with small-shot" and the elder of the two was hit in a leg. This caused the two Dharawal men to run to their huts and seize their spears and shields. Subsequently,
6231-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into
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6432-399: A specific territory. Consequently, conquering another group's territory may have been seen to be of little benefit. Ultimately, traditional Aboriginal warfare was aimed at continually asserting the superiority of one's own group over its neighbours, rather than conquering, destroying or displacing neighbouring groups. As the explorer Edward John Eyre observed in 1845, whilst Aboriginal culture
6633-408: A unique plan for settlers to purchase land in advance of their arrival, which was intended to ensure a balance of landowners and farm workers in the colony. The Colonial Office was very conscious of the recent history of the earlier occupations in the eastern states, where there was a significant conflict with the Aboriginal population. On the initial Proclamation Day in 1836 Governor Hindmarsh , made
6834-610: A warrior. Women were sometimes participants in warfare as warriors and as encouragers on the sidelines of formal battles, but more often as victims. While the selection and design of weapons varied from group to group, Aboriginal warriors used a combination of melee and missile weapons in traditional warfare. Spears, clubs and shields were commonly used in hand-to-hand fighting, with different types of shields favoured during exchanges of missiles and in close combat, and spears (often used in conjunction with spear throwers ), boomerangs and stones used as missile weapons. Available weapons had
7035-538: A year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of the 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated,
7236-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox
7437-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond
7638-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during
7839-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through
8040-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade
8241-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope
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8442-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c. 1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in
8643-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had
8844-481: Is only the one specific nominal term 'Great Britain' which invariably excludes Northern Ireland". The BBC historically preferred to use "Britain" as shorthand only for Great Britain, though the present style guide does not take a position except that "Great Britain" excludes Northern Ireland. The adjective "British" is commonly used to refer to matters relating to the United Kingdom and is used in law to refer to United Kingdom citizenship and nationality . People of
9045-538: Is ranked 2nd out of 180 countries in the Environmental Performance Index . A law has been passed that UK greenhouse gas emissions will be net zero by 2050. England accounts for 53 per cent of the UK, covering 50,350 square miles (130,395 km ). Most of the country consists of lowland terrain, with upland and mountainous terrain northwest of the Tees–Exe line which roughly divides
9246-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in
9447-599: Is sometimes used as a loose synonym for the United Kingdom as a whole. The word England is occasionally used incorrectly to refer to the United Kingdom as a whole, a mistake principally made by people from outside the UK. The term "Britain" is used as a synonym for Great Britain , but also sometimes for the United Kingdom. Usage is mixed: the UK Government prefers to use the term "UK" rather than "Britain" or "British" on its website (except when referring to embassies), while acknowledging that both terms refer to
9648-579: Is the Isle of Wight . Scotland accounts for 32 per cent of the UK, covering 30,410 square miles (78,772 km ). This includes nearly 800 islands , notably the Hebrides , Orkney Islands and Shetland Islands. Scotland is the most mountainous constituent country of the UK, the Highlands to the north and west are the more rugged region containing the majority of Scotland's mountainous land, including
9849-595: Is the highest peak in Wales. Wales has over 1,680 miles (2,704 kilometres) of coastline including the Pembrokeshire Coast . Several islands lie off the Welsh mainland, the largest of which is Anglesey ( Ynys Môn ). Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus . The last naturally occurring case
10050-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this
10251-588: The 1884 Reform Act championed by William Gladstone granting suffrage to a majority of males for the first time. The British population increased at a dramatic rate, accompanied by rapid urbanisation , causing significant social and economic stresses. By the late 19th century, the Conservatives under Benjamin Disraeli and Lord Salisbury initiated a period of imperial expansion in Africa , maintained
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#173277245266010452-534: The Atlantic slave trade , mainly between 1662 and 1807 when British or British-colonial slave ships transported nearly 3.3 million slaves from Africa. The slaves were taken to work on plantations , principally in the Caribbean but also North America . However, with pressure from the abolitionism movement , Parliament banned the trade in 1807, banned slavery in the British Empire in 1833, and Britain took
10653-650: The Battle of Culloden in 1746, after which the Scottish Highlanders were forcibly assimilated into Scotland by revoking the feudal independence of clan chiefs . The British colonies in North America that broke away in the American War of Independence became the United States . British imperial ambition turned towards Asia, particularly to India . British merchants played a leading part in
10854-663: The Cairngorms , Loch Lomond and The Trossachs and Ben Nevis which at 1,345 metres (4,413 ft) is the highest point in the British Isles. Wales accounts for less than 9 per cent of the UK, covering 8,020 square miles (20,779 km ). Wales is mostly mountainous, though South Wales is less mountainous than North and mid Wales . The highest mountains in Wales are in Snowdonia and include Snowdon ( Welsh : Yr Wyddfa ) which, at 1,085 metres (3,560 ft),
11055-523: The Commonwealth of Nations . The UK was the third country to develop a nuclear weapons arsenal (with its first atomic bomb test, Operation Hurricane , in 1952), but the post-war limits of Britain's international role were illustrated by the Suez Crisis of 1956. The international spread of the English language ensured the continuing international influence of its literature and culture . As
11256-643: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where
11457-767: The European Convention on Human Rights . The UK remained a great power with global diplomatic and military influence and a leading role in the United Nations and NATO . The UK broadly supported the United States' approach to the " war on terror " in the early 21st century. British troops fought in the War in Afghanistan , but controversy surrounded Britain's military deployment in Iraq , which saw
11658-583: The European Union (EU) in 1992, the UK was one of the 12 founding member states. From the late 1960s, Northern Ireland suffered communal and paramilitary violence (sometimes affecting other parts of the UK) conventionally known as the Troubles . It is usually considered to have ended with the 1998 Belfast "Good Friday" Agreement . Following a period of widespread economic slowdown and industrial strife in
11859-494: The Falkland Islands , leading to the 10-week Falklands War in which Argentine forces were defeated. The inhabitants of the islands are predominantly descendants of British settlers, and strongly favour British sovereignty, expressed in a 2013 referendum . From 1984, the UK economy was helped by the inflow of substantial North Sea oil revenues. Another British overseas territory, Gibraltar , ceded to Great Britain in
12060-523: The First Fleet established a penal colony at Sydney Cove in January 1788. Colonisation spread to present-day Tasmania and Victoria from 1803 onward. Since then the population density of non-Indigenous people has remained highest in this region of the Australian continent. However, conflict with Aboriginal people was never as intense and bloody in the south-eastern colonies as in Queensland and
12261-545: The French Revolutionary Wars and Napoleonic Wars (1792–1815), the United Kingdom emerged as the principal naval and imperial power (with London the largest city in the world from about 1830). Unchallenged at sea , British dominance was later described as Pax Britannica ("British Peace"), a period of relative peace among the great powers (1815–1914) during which the British Empire became
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#173277245266012462-725: The Kingdom of England and the Kingdom of Scotland united under the Treaty of Union to create the Kingdom of Great Britain . The Acts of Union 1800 incorporated the Kingdom of Ireland to create the United Kingdom of Great Britain and Ireland in 1801. Most of Ireland seceded from the UK in 1922 as the Irish Free State , and the Royal and Parliamentary Titles Act 1927 created the present United Kingdom. The UK became
12663-650: The Labour Party emerged from an alliance of trade unions and small socialist groups in 1900, and suffragettes campaigned for women's right to vote. Britain was one of the principal Allies that defeated the Central Powers in the First World War (1914–1918). Alongside their French, Russian and (after 1917) American counterparts, British armed forces were engaged across much of the British Empire and in several regions of Europe, particularly on
12864-588: The Liverpool Plains , with 16 British and up to 500 Indigenous Australians being killed between 1832 and 1838. The violence in this region included several massacres of Indigenous people, including the Waterloo Creek massacre and Myall Creek massacres in 1838, and did not end until 1843. Further violence took place in the New England region during the early 1840s. The British established
13065-636: The Martini-Henry rifle as well as rapid-fire rifles such as the Winchester rifle , becoming available. These weapons, when used on open ground and combined with the superior mobility provided by horses to surround and engage groups of Indigenous Australians, often proved successful. The Europeans also had to adapt their tactics to fight their fast-moving, often hidden enemies. Strategies employed included night-time surprise attacks, and positioning forces to drive Aboriginal people off cliffs or force them to retreat into rivers while attacking from both banks. Fighting between Indigenous Australians and European settlers
13266-441: The New South Wales Mounted Police , who began as mounted infantry from the third Regiment , and were first deployed against bushrangers around Bathurst in 1825. Later they were deployed to the upper Hunter Region in 1826 after fighting broke out there between Wonnarua and Kamilaroi people and settlers. From the 1830s settlers spread rapidly through inland eastern Australia, leading to widespread conflict. War took place across
13467-541: The New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred
13668-405: The Representation of the People Act 1918 . After the war, Britain became a permanent member of the Executive Council of the League of Nations and received a mandate over a number of former German and Ottoman colonies. Under the leadership of David Lloyd George , the British Empire reached its greatest extent, covering a fifth of the world's land surface and a quarter of its population. By
13869-463: The Soviet Union formed in 1941, leading the Allies against the Axis powers . There were eventual hard-fought victories in the Battle of the Atlantic , the North Africa campaign and the Italian campaign . British forces played important roles in the Normandy landings of 1944 and the liberation of Europe . The British Army led the Burma campaign against Japan, and the British Pacific Fleet fought Japan at sea. British scientists contributed to
14070-452: The United Kingdom ( UK ) or Britain , is a country in Northwestern Europe , off the coast of the continental mainland . It comprises England , Scotland , Wales , and Northern Ireland . The UK includes the island of Great Britain , the north-eastern part of the island of Ireland , and most of the smaller islands within the British Isles , making up a total area of 94,354 square miles (244,376 km ). Northern Ireland shares
14271-449: The Western Front . The high fatalities of trench warfare caused the loss of much of a generation of men, with lasting social effects in the nation and a great disruption in the social order. Britain had suffered 2.5 million casualties and finished the war with a huge national debt. The consequences of the war persuaded the government to expand the right to vote in national and local elections to all adult men and most adult women with
14472-471: The coastline paradox . It is connected to continental Europe by the Channel Tunnel , which at 31 miles (50 km) (24 miles (38 km) underwater) is the longest underwater tunnel in the world. The UK contains four terrestrial ecoregions: Celtic broadleaf forests , English Lowlands beech forests , North Atlantic moist mixed forests , and Caledonian conifer forests . The area of woodland in
14673-422: The common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15, the first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and
14874-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that
15075-436: The largest protest in British history in opposition to the government led by Tony Blair . The Great Recession severely affected the UK economy. The Cameron–Clegg coalition government of 2010 introduced austerity measures intended to tackle the substantial public deficits. Studies have suggested that policy led to significant social disruption and suffering. A referendum on Scottish independence in 2014 resulted in
15276-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of
15477-517: The "Black War" through a massive offensive. In an operation which became known as the " Black Line " ten percent of the colony's male civilian population were mobilised and marched across the settled districts in company with police and soldiers in an attempt to clear Indigenous Australians from the area. While few Indigenous people were captured, the operation discouraged the Indigenous raiding parties, and they gradually agreed to leave their land for
15678-619: The 16th century and established the Church of England . Moreover, it defined a national identity for England and slowly, but profoundly, changed people's religious beliefs. Wales was fully incorporated into the Kingdom of England , and Ireland was constituted as a kingdom in personal union with the English crown. In what was to become Northern Ireland, the lands of the independent Catholic Gaelic nobility were confiscated and given to Protestant settlers from England and Scotland. In 1603,
15879-401: The 1713 Treaty of Utrecht, is a key military base . A referendum in 2002 on shared sovereignty with Spain was rejected by 98.97% of voters in the territory. Around the end of the 20th century, there were major changes to the governance of the UK with the establishment of devolved administrations for Scotland, Wales and Northern Ireland. The statutory incorporation followed acceptance of
16080-464: The 1890s until Bunuba leader Jandamarra was killed in 1897. Sporadic conflict continued in northern Western Australia until the 1920s, with a Royal Commission held in 1926 finding that at least eleven Indigenous Australians had been murdered in the Forrest River massacre by a police expedition in retaliation for the death of a European. South Australia was settled in 1836 with no convicts and
16281-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses
16482-521: The 1970s, the Conservative government of the 1980s led by Margaret Thatcher initiated a radical policy of monetarism , deregulation, particularly of the financial sector (for example, the Big Bang in 1986) and labour markets, the sale of state-owned companies (privatisation), and the withdrawal of subsidies to others. In 1982, Argentina invaded the British territories of South Georgia and
16683-646: The 5th century) united with the Picts to create the Kingdom of Scotland in the 9th century. In 1066, the Normans invaded England from northern France. After conquering England , they seized large parts of Wales , conquered much of Ireland and were invited to settle in Scotland, bringing to each country feudalism on the Northern French model and Norman-French culture. The Anglo-Norman ruling class greatly influenced, but eventually assimilated with,
16884-550: The British expanded into inland New South Wales . Settlers who crossed the Blue Mountains were harassed by Wiradjuri warriors, who killed or wounded stock-keepers and stock and were subjected to retaliatory killings. In response, Governor Brisbane proclaimed martial law on 14 August 1824 to end "the Slaughter of Black Women and Children, and unoffending White Men". It remained in force until 11 December 1824, when it
17085-700: The Brittonic area mainly to what was to become Wales , Cornwall and, until the latter stages of the Anglo-Saxon settlement, the Hen Ogledd (northern England and parts of southern Scotland). Most of the region settled by the Anglo-Saxons became unified as the Kingdom of England in the 10th century. Meanwhile, Gaelic speakers in north-west Britain (with connections to the north-east of Ireland and traditionally supposed to have migrated from there in
17286-779: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,
17487-612: The Europeans, and although there were some instances of individuals and groups acquiring and using firearms, this was not widespread. In reality, the Indigenous peoples were never a serious military threat, regardless of how much the settlers may have feared them. On occasions large groups attacked Europeans in open terrain and a conventional battle ensued, during which the Aboriginal residents would attempt to use superior numbers to their advantage. This could sometimes be effective, with reports of them advancing in crescent formation in an attempt to outflank and surround their opponents, waiting out
17688-595: The Eyre Peninsula but were often ineffective due to the size of the area and the number of isolated settlements. By the mid-1840s, after conflicts sometimes involving large numbers of Aboriginal people, the greater lethality of the white people's weapons had an effect. Several alleged leaders of attacks by Aboriginal people were tried and executed in Adelaide. The experience of the Port Lincoln settlement on
17889-465: The Eyre Peninsula was repeated in the South East of the state and in the north as settlers encroached on the Aboriginal population. The government attempted to apply the sentiments of the state's proclamation, but the contradictions between these sentiments and the dispossession that the settlement involved made conflict inevitable. Fighting also took place in early pre-separation Victoria after it
18090-583: The Hawkesbury Valley and ended the conflict by killing 14 Indigenous Australians in an ambush on their campsite. Indigenous Australians led by Pemulwuy also conducted raids around Parramatta during the period between 1795 and 1802. These attacks led Governor Philip Gidley King to issue an order in 1801 which authorised settlers to shoot Indigenous Australians on sight in Parramatta, Georges River and Prospect areas. Conflict began again when
18291-520: The Indigenous population—such as the common cold, flu, measles , venereal diseases and tuberculosis —also had an impact, significantly reducing their numbers and tribal cohesion, and so limiting their ability to adapt to or resist invasion and dispossession. According to the historian John Connor, traditional Aboriginal warfare should be examined on its own terms and not by definitions of war derived from other societies. Aboriginal people did not have distinct ideas of war and peace, and traditional warfare
18492-830: The Manhattan Project whose task was to build an atomic weapon. Once built, it was decided, with British consent, to use the weapon against Japan. The UK was one of the Big Three powers (along with the US and the Soviet Union) who met to plan the post-war world ; it drafted the Declaration by United Nations with the United States and became one of the five permanent members of the United Nations Security Council . It worked closely with
18693-476: The Name of Great Britain". The term "United Kingdom" has occasionally been used as a description for the former Kingdom of Great Britain , although its official name from 1707 to 1800 was simply "Great Britain". The Acts of Union 1800 formed the United Kingdom of Great Britain and Ireland . Following the partition of Ireland and the independence of the Irish Free State in 1922, which left Northern Ireland as
18894-568: The Normans conquered England . With the end of the Wars of the Roses the English state stabilised and began to grow in power, resulting by the 16th century in the annexation of Wales , the domination of Scotland , and the establishment of the British Empire . Over the course of the 17th century, the role of the British monarchy was reduced, particularly as a result of the English Civil War . In 1707,
19095-564: The Northern Territory and Western Australia. The effects of disease, loss of hunting grounds and starvation of the Aboriginal population were significant. There are indications that smallpox epidemics may have impacted heavily on some Aboriginal communities , with depopulation in large sections of what is now Victoria , New South Wales and Queensland up to 50% or more, even before the move inland from Sydney of squatters and their livestock. Other diseases hitherto unknown in
19296-716: The Scottish electorate voting by 55.3 to 44.7% to remain part of the United Kingdom. In 2016, 51.9 per cent of voters in the United Kingdom voted to leave the European Union . The UK left the EU in 2020. On 1 May 2021, the EU–UK Trade and Cooperation Agreement came into force. The COVID-19 pandemic had a severe impact on the UK's economy , caused major disruptions to education and had far-reaching impacts on society and politics in 2020 and 2021. The United Kingdom
19497-556: The Second World War damaged Britain's economic power and a global wave of decolonisation led to the independence of most British colonies. The United Kingdom is a constitutional monarchy and parliamentary democracy . The UK has three distinct jurisdictions: England and Wales , Scotland , and Northern Ireland . Since 1999, Scotland, Wales and Northern Ireland have their own governments and parliaments which control various devolved matters. A developed country ,
19698-501: The UK has the world's sixth-largest economy by nominal gross domestic product (GDP). It is a nuclear state , and is ranked fifth globally in military expenditure . The UK has been a permanent member of the UN Security Council since its first session in 1946. It is a member of the Commonwealth of Nations , Council of Europe , G7 , OECD , NATO , Five Eyes , AUKUS and CPTPP . British influence can be observed in
19899-484: The UK in 2023 is estimated to be 3.25 million hectares, which represents 13% of the total land area in the UK. Most of the United Kingdom has a temperate climate, with generally cool temperatures and plentiful rainfall all year round. The temperature varies with the seasons seldom dropping below 0 °C (32 °F ) or rising above 30 °C (86 °F). Some parts, away from the coast, of upland England, Wales, Northern Ireland and most of Scotland, experience
20100-961: The UK into lowland and upland areas. Lowland areas include Cornwall , the New Forest , the South Downs and the Norfolk Broads . Upland areas include the Lake District , the Pennines , the Yorkshire Dales , Exmoor , and Dartmoor . The main rivers and estuaries are the Thames , Severn , and the Humber . England's highest mountain is Scafell Pike , at 978 metres (3,209 ft) in the Lake District; its largest island
20301-402: The United Kingdom and that elsewhere "British government" is used at least as frequently as "United Kingdom government". The UK Permanent Committee on Geographical Names recognises "United Kingdom", "UK" and "U.K." as shortened and abbreviated geopolitical terms for the United Kingdom of Great Britain and Northern Ireland in its toponymic guidelines; it does not list "Britain" but notes that "it
20502-411: The United Kingdom is 1339.7 hours, which is just under 30% of the maximum possible. The hours of sunshine vary from 1200 to about 1580 hours per year, and since 1996 the UK has been and still is receiving above the 1981 to 2010 average hours of sunshine. Climate change has a serious impact on the country. A third of food price rise in 2023 is attributed to climate change. As of 2022, the United Kingdom
20703-436: The United Kingdom use several different terms to describe their national identity and may identify themselves as being British , English , Scottish , Welsh , Northern Irish , or Irish ; or as having a combination of different national identities. Settlement by Cro-Magnons of what was to become the United Kingdom occurred in waves beginning by about 30,000 years ago. The island has been continuously inhabited only since
20904-685: The United Kingdom. The 1928 Equal Franchise Act gave women electoral equality with men in national elections. Strikes in the mid-1920s culminated in the General Strike of 1926 . Britain had still not recovered from the effects of the First World War when the Great Depression (1929–1932) led to considerable unemployment and hardship in the old industrial areas, as well as political and social unrest with rising membership in communist and socialist parties. A coalition government
21105-770: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,
21306-640: The United States to establish the IMF , World Bank and NATO . The war left the UK severely weakened and financially dependent on the Marshall Plan , but it was spared the total war that devastated eastern Europe. In the immediate post-war years, the Labour government under Clement Attlee initiated a radical programme of reforms, which significantly impacted British society in the following decades . Major industries and public utilities were nationalised ,
21507-565: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor
21708-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add
21909-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing
22110-521: The acquisition and settlement of overseas colonies , particularly in North America and the Caribbean. Though previous attempts at uniting the two kingdoms within Great Britain in 1606, 1667, and 1689 had proved unsuccessful, the attempt initiated in 1705 led to the Treaty of Union of 1706 being agreed and ratified by both parliaments. On 1 May 1707, the Kingdom of Great Britain was formed,
22311-518: The age of frontier conflict closed. Frontier encounters in Australia were not universally negative. Positive accounts of Aboriginal customs and encounters are also recorded in the journals of early European explorers, who often relied on Aboriginal guides and assistance: Charles Sturt employed Aboriginal envoys to explore the Murray-Darling ; the lone survivor of the Burke and Wills expedition
22512-557: The best known single event, occurred on 28 October 1833 when a party of British colonisers led by Governor Stirling attacked an Indigenous campsite on the banks of the Murray River . The Noongar nation, forced from traditional hunting grounds and denied access to sacred sites, turned to stealing settlers' crops and killing livestock to survive. In 1831 a Noongar person was murdered for taking potatoes; this resulted in Yagan killing
22713-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When
22914-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate
23115-516: The characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through the smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after
23316-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized
23517-469: The continent's northeast. More settlers, as well as Indigenous Australians, were killed on the Queensland frontier than in any other Australian colony. The reason is simple, and is reflected in all evidence and sources dealing with this subject: there were more Aboriginal people in Queensland. The territory of Queensland was the single most populated section of pre-contact Indigenous Australia, reflected not only in all pre-contact population estimates but also in
23718-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as
23919-736: The decades-long process of European integration , the UK was a founding member of the Western European Union , established with the London and Paris Conferences in 1954. In 1960 the UK was one of the seven founding members of the European Free Trade Association (EFTA), but in 1973 it left to join the European Communities (EC). In a 1975 referendum 67% voted to stay in it. When the EC became
24120-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly
24321-512: The disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It was one of several diseases introduced by the Columbian exchange to
24522-447: The early 20th century following the federation of the Australian colonies in 1901, with some occurring as late as 1934. Conflicts occurred in a number of locations across Australia. Estimates of the number of people killed in the fighting vary considerably. In 1770 an expedition from Great Britain under the command of then-Lieutenant James Cook made the first voyage by the British along the Australian east coast. On 29 April, Cook and
24723-461: The eastern colonies. There were many instances of conflict between Aboriginal people and the drovers, with the former desiring the protection of the Country and the latter quick to shoot to protect themselves and their flocks. One expedition leader (Buchanan) recorded at least six conflicts and the deaths of eight Aboriginal people. In 1840 the ship Maria was wrecked at Cape Jaffa, on the southeast coast. A search party found that all 26 survivors of
24924-483: The eastern parts are the driest. Atlantic currents, warmed by the Gulf Stream , bring mild winters, especially in the west where winters are wet and even more so over high ground. Summers are warmest in the southeast of England and coolest in the north. Heavy snowfall can occur in winter and early spring on high ground, and occasionally settles to great depth away from the hills. The average total annual sunshine in
25125-480: The escape of raiders. Initial peaceful relations between Indigenous Australians and Europeans began to be strained several months after the First Fleet established Sydney on 26 January 1788. The local Indigenous people became suspicious when the British began to clear land and catch fish, and in May 1788 five convicts were killed and an Indigenous man was wounded. The British grew increasingly concerned when groups of up to three hundred Indigenous people were sighted at
25326-606: The first appeal on behalf of an Indigenous Australian , Dhakiyarr Wirrpanda, was launched to the High Court of Australia in Tuckiar v The King . Following the crisis, the anthropologist Donald Thomson was dispatched by the government to live among the Yolngu. Elsewhere around this time, activists like Sir Douglas Nicholls were commencing their campaigns for Aboriginal rights within the established Australian political system and
25527-404: The first industrialised country and was the world's foremost power for the majority of the 19th and early 20th centuries, particularly during the " Pax Britannica " between 1815 and 1914. At its height in the 1920s, the British Empire encompassed almost a quarter of the world's landmass and population, and was the largest empire in history . However, its involvement in the First World War and
25728-547: The first volley of shots and then hurling their spears whilst settlers reloaded. Usually, however, such open warfare proved more costly for the Indigenous Australians than the Europeans. Central to the success of the Europeans was the use of firearms, but the advantages this afforded have often been overstated. Prior to the 19th century, firearms were often cumbersome muzzle-loading, smooth-bore, single shot weapons with flint-lock mechanisms. Such weapons produced
25929-594: The first year, Britain and its Empire continued the war against Germany. Churchill engaged industry, scientists and engineers to support the government and the military in the prosecution of the war effort. In 1940, the Royal Air Force defeated the German Luftwaffe in the Battle of Britain . Urban areas suffered heavy bombing during the Blitz . The Grand Alliance of Britain, the United States and
26130-587: The formal control it exerted over its own colonies, British dominance of much of world trade meant that it effectively controlled the economies of regions such as East Asia and Latin America . Throughout the Victorian era , political attitudes favoured free trade and laissez-faire policies. Beginning with the Great Reform Act in 1832, Parliament gradually widened the voting franchise , with
26331-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to
26532-699: The global hegemon and adopted the role of global policeman. From 1853 to 1856, Britain took part in the Crimean War , allied with the Ottoman Empire against Tsarist Russia , participating in the naval battles of the Baltic Sea known as the Åland War in the Gulf of Bothnia and the Gulf of Finland , among others. Following the Indian Rebellion in 1857 , the British government led by Lord Palmerston assumed direct rule over India . Alongside
26733-506: The group for the actions of one of its members, such as a murder. In some cases these involved sneaking into the opposition camp at night and silently killing one or more members of the group. Connor describes traditional Aboriginal warfare as both limited and universal. It was limited in terms of: Traditional Aboriginal warfare was also universal, as the entire community participated in warfare, boys learnt to fight by playing with toy melee and missile weapons , and every initiated male became
26934-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox
27135-471: The higher death toll was also caused by the technological and logistic advantages enjoyed by Europeans. Indigenous tactics varied, but were mainly based on pre-existing hunting and fighting practices—utilizing spears, clubs and other simple weapons. Unlike the cases with the American Indian Wars and New Zealand Wars , in the main, the indigenous peoples failed to adapt to meet the challenge of
27336-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,
27537-420: The immediate punishment for the massacre and those condemning this form of justice outside the normal law. The town of Port Lincoln , which was readily accessible by sea from Adelaide, became an early new settlement. A small number of shepherds began to steal land that was home to a large Aboriginal population. Deaths on both sides occurred and settlers demanded better protection. Police and soldiers were sent to
27738-672: The island. Fighting continued into the 1840s along the Avon River near York . In the Busselton region, relations between white settlers and the Wardandi people were strained to the point of violence, resulting in several Aboriginal deaths. In June 1841, George Layman was speared to death by Wardandi Elder Gaywal. According to one source, Layman had got involved in an argument between Gaywal and another Wardandi person over their allocation of damper, and had pulled Gaywal's beard, which
27939-403: The kingdoms of England, Scotland and Ireland were united in a personal union when James VI, King of Scots , inherited the crowns of England and Ireland and moved his court from Edinburgh to London; each country nevertheless remained a separate political entity and retained its separate political, legal, and religious institutions. In the mid-17th century, all three kingdoms were involved in
28140-411: The largest in Western Europe , with a population of 14.9 million. The cities of Edinburgh , Cardiff , and Belfast are the national capitals of Scotland, Wales, and Northern Ireland, respectively. The lands of the UK have been inhabited continuously since the Neolithic . In AD 43 the Roman conquest of Britain began; the Roman departure was followed by Anglo-Saxon settlement . In 1066,
28341-408: The last retreat of the ice around 11,500 years ago. By the end of the region's prehistoric period , the population is thought to have belonged largely to a culture termed Insular Celtic , comprising Brittonic Britain and Gaelic Ireland . The Roman conquest , beginning in 43 AD, and the 400-year rule of southern Britain , was followed by an invasion by Germanic Anglo-Saxon settlers, reducing
28542-409: The legal and political systems of many of its former colonies , and British culture remains globally influential, particularly in language , literature , music and sport . English is the world's most widely spoken language and the third-most spoken native language . The Acts of Union 1707 declared that the Kingdom of England and Kingdom of Scotland were "United into One Kingdom by
28743-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after
28944-471: The local cultures. Subsequent medieval English kings completed the conquest of Wales and tried unsuccessfully to annex Scotland . Asserting its independence in the 1320 Declaration of Arbroath , Scotland maintained its independence thereafter, albeit in near-constant conflict with England . In 1215 the Magna Carta was the first document to state that no government was above the law, that citizens have rights protecting them and that they were entitled to
29145-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in
29346-436: The major part of the British Isles archipelago and includes the island of Great Britain, the north-eastern one-sixth of the island of Ireland and some smaller surrounding islands. It lies between the North Atlantic Ocean and the North Sea with the southeast coast coming within 22 miles (35 km) of the coast of northern France, from which it is separated by the English Channel . The Royal Greenwich Observatory in London
29547-408: The malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and the first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by
29748-411: The mapping of pre-contact Australia (see Horton's Map of Aboriginal Australia ). The Indigenous population distribution illustrated below is based on two independent sources, firstly on two population estimates made by anthropologists and a social historian in 1930 and in 1988, and secondly on the basis of the distribution of known tribal land. All evidence suggests that the territory of Queensland had
29949-619: The mid-1920s, most of the British population could listen to BBC radio programmes. Experimental television broadcasts began in 1929 and the first scheduled BBC Television Service commenced in 1936. The rise of Irish nationalism , and disputes within Ireland over the terms of Irish Home Rule , led eventually to the partition of the island in 1921. A period of conflict in what is now Northern Ireland occurred from June 1920 until June 1922. The Irish Free State became independent, initially with Dominion status in 1922, and unambiguously independent in 1931 . Northern Ireland remained part of
30150-429: The natives, who are to be considered as much under the Safeguard of the law as the Colonists themselves, and equally entitled to the privileges of British Subjects. Governor Gawler declared in 1840 that Aboriginal people "have exercised distinct, defined, and absolute right or proprietary and hereditary possession ... from time immemorial". The Governor ordered land to be set aside for the Aboriginal population, but there
30351-731: The occupation of their lands. European diseases decimated Indigenous populations, and the occupation or destruction of lands and food resources sometimes led to starvation. By and large neither the Europeans nor the Indigenous peoples approached the conflict in an organised sense, with the conflict more one between groups of colonisers and individual Indigenous groups rather than systematic warfare, even if at times it did involve British soldiers and later formed mounted police units. Not all Indigenous Australians resisted European encroachment on their lands either, whilst many also served in mounted police units and were involved in attacks on other tribes. Colonisers in turn often reacted with violence, resulting in
30552-463: The only part of the island of Ireland within the United Kingdom, the name was changed in 1927 to the "United Kingdom of Great Britain and Northern Ireland". Although the United Kingdom is a sovereign country, England, Scotland, Wales and Northern Ireland are also widely referred to as countries . The UK Prime Minister's website has used the phrase "countries within a country" to describe the United Kingdom. Some statistical summaries, such as those for
30753-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox
30954-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox
31155-464: The other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of
31356-523: The outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series, the case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form,
31557-479: The outskirts of the colony in June. Despite this, Phillip attempted to avoid conflict, and forbade reprisals after being speared in 1790. He did, however, authorise two punitive expeditions in December 1790 after his huntsman was killed by an Indigenous warrior named Pemulwuy , but neither was successful. During the 1790s and early 19th century the British occupied areas along the Australian coastline. These settlements initially occupied small amounts of land, and there
31758-420: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of
31959-447: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because
32160-491: The prodromal illness still occurred but may have been less severe than in the ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)
32361-442: The rest of Europe, royal absolutism would not prevail, and a professed Catholic could never accede to the throne. The British constitution would develop on the basis of constitutional monarchy and the parliamentary system . With the founding of the Royal Society in 1660, science was greatly encouraged. During this period, particularly in England, the development of naval power and the interest in voyages of discovery led to
32562-406: The result of the Acts of Union 1707 between the Kingdom of England and Kingdom of Scotland . In the 18th century, cabinet government developed under Robert Walpole , in practice the first prime minister (1721–1742). A series of Jacobite uprisings sought to remove the Protestant House of Hanover from the throne and restore the Catholic House of Stuart . The Jacobites were finally defeated at
32763-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before
32964-479: The second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By the sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to
33165-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this
33366-447: The skills of Aboriginal stockmen became highly regarded. The first frontier war began in 1795 when encroaching British settlers established farms along the Hawkesbury River west of Sydney. Some of these settlements were established by soldiers as a means of providing security to the region. Local Darug people raided farms until Governor Macquarie dispatched a detachment of the 46th Regiment of Foot in 1816. This detachment patrolled
33567-427: The smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is a less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash)
33768-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There
33969-425: The temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to
34170-411: The touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week, the pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced
34371-436: The twelve NUTS 1 regions , refer to Scotland, Wales and Northern Ireland as "regions". Northern Ireland is also referred to as a "province". With regard to Northern Ireland, the descriptive name used "can be controversial, with the choice often revealing one's political preferences". The term "Great Britain" conventionally refers to the island of Great Britain, or politically to England, Scotland and Wales in combination. It
34572-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on
34773-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox
34974-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in
35175-505: The whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on the Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and
35376-428: The wreck had been massacred. The Governor summoned the Executive Council under martial law and a police party was sent to the district to deliver summary justice against the local Indigenous people. The police party apprehended a number of Aboriginal people; two men were implicated, tried by a tribunal from members of the expedition, found guilty, and hanged. There was a vigorous debate in the colony between those approving
35577-532: Was "so varied in detail", it was "similar in general outline and character", and Connor observes that there were sufficient similarities in weapons and warfare of these groups to allow generalisations about traditional Aboriginal warfare to be made. In 1840, the American-Canadian ethnologist Horatio Hale identified four types of Australian Aboriginal traditional warfare; formal battles, ritual trials, raids for women, and revenge attacks. Formal battles involved fighting between two groups of warriors, which ended after
35778-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of
35979-509: Was bitter opposition from settlers who insisted on a right to choose the best land. Eventually, the land was available to Aboriginal people only if it promoted their "Christianisation" and they became farmers. The designation of the Aboriginal population as British citizens gave them rights and responsibilities of which they had no knowledge and ignored existing Aboriginal customary law. However, Aboriginal people could not testify in court, since, not being Christians, they could not swear an oath on
36180-416: Was chosen as the defining point of the Prime Meridian at the International Meridian Conference in 1884. The United Kingdom lies between latitudes 49° and 61° N , and longitudes 9° W and 2° E . Northern Ireland shares a 224-mile (360 km) land boundary with the Republic of Ireland. The coastline of Great Britain is 11,073 miles (17,820 km) long, though measurements can vary greatly due to
36381-429: Was common, taking place between groups on an ongoing basis, with great rivalries being maintained over extended periods of time. The aims and methods of traditional Aboriginal warfare arose from their small autonomous social groupings. The fighting of a war to conquer enemy territory was not only beyond the resources of any of these Aboriginal groupings, it was contrary to a culture that was based on spiritual connections to
36582-822: Was considered a grave insult. According to another source, Layman had hired two of Gaywal's wives to work on his farm and would not let them go back to their husbands. A manhunt for Layman's killer went on for several weeks, involving much bloodshed as Captain John Molloy , the Bussell brothers, and troops murdered unknown numbers of Aboriginal residents in what has become known as the Wonnerup massacre . The posse eventually murdered Gaywal and abducted his three sons, two of whom were imprisoned on Rottnest Island . The discovery of gold near Coolgardie in 1892 brought thousands of prospectors onto Wangkathaa land, causing sporadic fighting. Continued European settlement and expansion in Western Australia led to further frontier conflict, Bunuba warriors also attacked European settlements during
36783-400: Was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash . Over a number of days, the skin rash turned into
36984-443: Was expected to stand their ground and accept the punishment. Some Aboriginal men had effective property rights over women and raids for women were essentially about transferring property from one group to another to ensure the survival of a group through women's food-gathering and childbearing roles. The final type of Aboriginal traditional warfare described by Hale was the revenge attack, undertaken by one group against another to punish
37185-404: Was formed in 1931. Nonetheless, "Britain was a very wealthy country, formidable in arms, ruthless in pursuit of its interests and sitting at the heart of a global production system." After Nazi Germany invaded Poland in 1939, Britain entered the Second World War . Winston Churchill became prime minister and head of a coalition government in 1940. Despite the defeat of its European allies in
37386-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation
37587-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from
37788-466: Was little conflict between the colonisers and Indigenous peoples. Fighting broke out when the settlements expanded, however, disrupting traditional Indigenous food-gathering activities, and subsequently followed the pattern of European invasion in Australia for the next 150 years. Whilst the reactions of the Aboriginal inhabitants to the sudden invasion by the British were varied, they became hostile when their presence led to competition over resources, and to
37989-494: Was localised, as Indigenous groups did not form confederations capable of sustained resistance. Conflict emerged as a series of violent engagements, and massacres across the continent. According to the historian Geoffrey Blainey , in Australia during the colonial period: "In a thousand isolated places there were occasional shootings and spearings. Even worse, smallpox, measles, influenza and other new diseases swept from one Aboriginal camp to another ... The main conqueror of Aborigines
38190-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox
38391-417: Was not necessarily understood or recognised in any official respect by settlers (language barriers made communication extremely difficult), and the English-speaking colony abided by its own legal doctrine. The colony's Governor , Captain Arthur Phillip , was instructed to "live in amity and kindness" with Indigenous Australians and sought to avoid conflict. The British colonisation of Australia commenced when
38592-429: Was not part of British law at the time and Cook was instructed only to take possession of land if he found it uninhabited. Nevertheless, Cook took possession of the east coast of New Holland for Britain on 22 August 1770 when on Possession Island off the west coast of Cape York Peninsula . The British Government decided to establish a prison colony in Australia in 1786. The law system practised by Indigenous Australians
38793-423: Was nursed by local Aboriginal residents, and the famous Aboriginal explorer Jackey Jackey loyally accompanied his ill-fated friend Edmund Kennedy to Cape York . Respectful studies were conducted by such as Walter Baldwin Spencer and Frank Gillen in their renowned anthropological study The Native Tribes of Central Australia (1899); and by Donald Thomson of Arnhem Land (c.1935–1943). In inland Australia,
38994-492: Was proclaimed that "the judicious and humane Measures pursued by the Magistrates assembled at Bathurst have restored Tranquillity without Bloodshed". There is a display of the weaponry and history of this conflict at the National Museum of Australia . This includes a commendation by Governor Brisbane of the deployment of the troops under Major Morisset : I felt it necessary to augment the Detachment at Bathurst to 75 men who were divided into various small parties, each headed by
39195-456: Was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox, the malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and
39396-501: Was settled in 1834. In 1833–34, the battle for rights to a beached whale between whalers and people of the Gunditjmara nation resulted in the Convincing Ground massacre near Portland, Victoria . The 1836 Mount Cottrell massacre was a reprisal for the killing of a prominent Van Diemen's Land squatter Charles Franks who squatted on land west of the Melbourne's fledgling settlement. United Kingdom The United Kingdom of Great Britain and Northern Ireland , commonly known as
39597-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout
39798-432: Was the first country in the world to use an approved COVID-19 vaccine , developing its own vaccine through a collaboration between Oxford University and AstraZeneca , which allowed the UK's vaccine rollout to be among the fastest in the world. The total area of the United Kingdom is approximately 94,354 square miles (244,376 km ), with a land area of 93,723 square miles (242,741 km ). The country occupies
39999-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it
40200-460: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed
40401-424: Was to be disease and its ally, demoralization". The Caledon Bay crisis of 1932–34 saw one of the last incidents of violent interaction on the "frontier" of indigenous and non-indigenous Australia, which began when the spearing of Japanese poachers who had been molesting Yolngu women was followed by the killing of a policeman. As the crisis unfolded, national opinion swung behind the Aboriginal people involved, and
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