161-601: Nuuk ( Greenlandic pronunciation: [nuːk] ; Danish : Nuuk , formerly Godthåb [ˈkʌtˌhɔˀp] ) is the capital of and most populous city in Greenland , an autonomous territory in the Kingdom of Denmark . Nuuk is the seat of government and the territory's largest cultural and economic center. Nuuk is also the seat of government for the Sermersooq municipality . In January 2024, it had
322-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether
483-456: A monopoly on the electricity in Greenland. Since 1993, Nuuk has received its electric power mainly from Buksefjord hydroelectric power plant by way of a 132 kV powerline crossing Ameralik fjord over a distance of 5,376 m (17,638 ft), the world's longest free span. Nuuk has several educational institutions of higher learning. The University of Greenland (Ilisimatusarfik),
644-429: A "difficult language to learn, acquire and understand", and some evidence shows that children are slower to acquire the phonological distinctions of Danish compared with other languages. The grammar is moderately inflective with strong (irregular) and weak (regular) conjugations and inflections. Nouns, adjectives, and demonstrative pronouns distinguish common and neutral gender. Like English, Danish only has remnants of
805-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but
966-415: A discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on the distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach
1127-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox
1288-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major
1449-577: A former case system , particularly in the pronouns. Unlike English, it has lost all person marking on verbs. Its word order is V2 , with the finite verb always occupying the second slot in the sentence. Danish is a Germanic language of the North Germanic branch . Other names for this group are the Nordic or Scandinavian languages. Along with Swedish, Danish descends from the Eastern dialects of
1610-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in
1771-526: A literary language. Also in this period, Danish began to take on the linguistic traits that differentiate it from Swedish and Norwegian, such as the stød , the voicing of many stop consonants, and the weakening of many final vowels to /e/. The first printed book in Danish dates from 1495, the Rimkrøniken ( Rhyming Chronicle ), a history book told in rhymed verses. The first complete translation of
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#17327718172141932-571: A long history of habitation. The area around Nuuk was first occupied by the ancient, pre-Inuit, Paleo-Eskimo people of the Saqqaq culture as far back as 2200 BC when they lived in the area around the now abandoned settlement of Qoornoq . For a long time, it was occupied by the Dorset culture around the former settlement of Kangeq , but they disappeared from the Nuuk district before AD 1000. The Nuuk area
2093-718: A native of Greenland and the second woman in Denmark to become a bishop. The Herrnhut House was the center of the Moravian mission of New Herrnhut . Other landmarks include the Hans Egede Church and the Statue of Hans Egede . Greenland National Museum is in Nuuk and was one of the first museums established in Greenland, inaugurated in the mid-1960s. The museum has many artifacts and exhibits related to Greenland's archaeology, history, art, and handicrafts, and contains
2254-707: A number of Danes remained as a minority within German territories . After the occupation of Denmark by Germany in World War II, the 1948 orthography reform dropped the German-influenced rule of capitalizing nouns, and introduced the letter ⟨å⟩ . Three 20th-century Danish authors have become Nobel Prize laureates in Literature : Karl Gjellerup and Henrik Pontoppidan (joint recipients in 1917) and Johannes V. Jensen (awarded 1944). With
2415-480: A population of 19,872, - more than a third of the country’s population - making it one of the smallest capital cities in the world by population . Nuuk is considered a modernized city after the policy began in 1950. The city was founded in 1728 by the Dano-Norwegian missionary Hans Egede when he relocated from the earlier Hope Colony ( Haabets Koloni ) where he arrived in 1721. The governor Claus Paarss
2576-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on
2737-474: A quarter of the country's native population. As the capital of Greenland, Nuuk is the administrative center of the country, containing all of the important government buildings and institutions. The public sector bodies are also the town's largest employer. As of January 2021, the mayor of Nuuk is Charlotte Ludvigsen. She replaced former mayor Asii Chemnitz Narup in 2019 following a social media scandal involving posts criticizing her party. Like Narup, Ludvigsen
2898-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with
3059-400: A result of the high cost of flying goods to Greenland, Nuuk and other towns in Greenland are connected to Denmark by cargo vessels which sail mainly from Aalborg during the warmer months after the winter ice has melted. They bring clothing, flour, medicine, timber and machinery and return with deep-frozen shrimp and fish. For most of the year, Nuuk is served twice-weekly by the coastal ferry of
3220-482: A similarity in pronunciation, combined with the long tradition of having Danish as a written language, which has led to similarities in vocabulary. Among younger Danes, Copenhageners are worse at understanding Swedish than Danes from the provinces. In general, younger Danes are not as good at understanding the neighboring languages as the young in Norway and Sweden. The Danish philologist Johannes Brøndum-Nielsen divided
3381-455: A small fishing settlement with a harbor, but as the economy developed rapidly during the 1970s and 1980s, the fishing industry in the capital declined. The port is nevertheless still home to almost half of Greenland's fishing fleet. The local Royal Greenland processing plant absorbs landed seafood amounting to over DKK 50 million (US$ 7 million) per annum, mainly (80%) shrimp , but also cod , lumpfish and halibut . Seafood, including seal,
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#17327718172143542-586: A so-called multiethnolect in the urban areas, an immigrant Danish variety (also known as Perkerdansk ), combining elements of different immigrant languages such as Arabic, Turkish, and Kurdish, as well as English and Danish. Within the Danish Realm , Danish is the national language of Denmark and one of two official languages of the Faroe Islands (alongside Faroese ). There is a Faroese variant of Danish known as Gøtudanskt . Until 2009, Danish
3703-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into
3864-401: A third since 1990, and risen by almost 21% since 2000. In addition to those born in Greenland, data from 2015 showed 3,826 were born outside the country. Attracted by good employment opportunities with high wages, Danes have continued to settle in the town. Today, Nuuk has the highest proportion of Danes of any town in Greenland. Half of Greenland's immigrants live in Nuuk, which also accounts for
4025-625: A variant of Standard Danish, Southern Schleswig Danish , is spoken in the area. Since 2015, Schleswig-Holstein has officially recognized Danish as a regional language , just as German is north of the border. Furthermore, Danish is one of the official languages of the European Union and one of the working languages of the Nordic Council . Under the Nordic Language Convention , Danish-speaking citizens of
4186-407: A very large vowel inventory consisting of 27 phonemically distinctive vowels , and its prosody is characterized by the distinctive phenomenon stød , a kind of laryngeal phonation type . Due to the many pronunciation differences that set Danish apart from its neighboring languages, particularly the vowels, difficult prosody and "weakly" pronounced consonants, it is sometimes considered to be
4347-602: A year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of the 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated,
4508-460: Is 68 km/h. The average monthly temperature (7.4 °C (45.3 °F) in July) is colder than what is considered the limit for trees (10 °C (50 °F) during the warmest month). There are a few planted trees which do not sustain well. With 19,872 inhabitants as of January 2024, Nuuk is by far the largest town in Greenland. The population of Nuuk has doubled since 1977, increased by over
4669-515: Is a North Germanic language from the Indo-European language family spoken by about six million people, principally in and around Denmark . Communities of Danish speakers are also found in Greenland , the Faroe Islands , and the northern German region of Southern Schleswig , where it has minority language status. Minor Danish-speaking communities are also found in Norway , Sweden ,
4830-700: Is a West Germanic language descended from Old English. Old Norse exerted a strong influence on Old English in the early medieval period. The shared Germanic heritage of Danish and English is demonstrated with many common words that are very similar in the two languages. For example, when written, commonly used Danish verbs, nouns, and prepositions such as have , over , under , for , give , flag , salt , and arm are easily recognizable to English speakers. Similarly, some other words are almost identical to their Scots equivalents, e.g. kirke (Scots kirk , i.e., 'church') or barn (Scots and northern English bairn , i.e. 'child'). In addition,
4991-622: Is a member of the Inuit Ataqatigiit party. Greenland's self-government parliament , the Inatsisartut, is in Nuuk. It has 31 seats and its members are elected by popular vote on the basis of proportional representation to serve four-year terms. All of Greenland's major political parties have their headquarters in Nuuk, including the Inuit Ataqatigiit, Siumut , Democrats , Atassut , Association of Candidates and
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5152-560: Is a multi-purpose stadium, used mostly for football games. The stadium has a capacity of 2,000. The stadium can also be used as an entertainment venue: the Scottish rock band Nazareth performed at the venue. Nuuk also has the Godthåbhallen , a handball stadium. It is the home of the Greenland men's national handball team and has a capacity of 1,000. There is a hill for alpine skiing with an altitude difference around 300 meters on
5313-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox
5474-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond
5635-406: Is also sold in abundance in Nuuk's fish markets, the largest being Kalaaliaraq Market . Minerals including zinc and gold have contributed to the development of Nuuk's economy. The city, like much of Greenland, is heavily dependent upon Danish investment and relies on Denmark for block funding. All of Greenland's electricity is supplied by the government-owned company Nukissiorfiit , which has
5796-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during
5957-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through
6118-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade
6279-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope
6440-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c. 1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in
6601-430: Is its closest relative. East Germanic languages West Germanic languages Icelandic Faroese Norwegian Danish Swedish Approximately 2,000 uncompounded Danish words are derived from Old Norse and ultimately from Proto Indo-European . Of these 2,000, 1,200 are nouns, 500 are verbs and 180 are adjectives. Danish has also absorbed many loanwords , most of which were borrowed from Low German of
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6762-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had
6923-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in
7084-485: Is the central hospital of Greenland. The Nuuk Tourist Office was built in 1992 to house the headquarters of the new National Tourist Board of Greenland. Shops in Nuuk offer local art and craftwork. In July 2012, Greenland's first shopping center, Nuuk Center (NC) , opened. The center has Greenland's first underground parking. Several supermarkets exist, such as Nuuk Center, Pisiffik , Brugseni , and Spar . Nuuk has an international airport 4 km (2.5 mi) to
7245-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this
7406-436: The skarre-R , the uvular R sound ( [ʁ] ), began spreading through Denmark, likely through influence from Parisian French and German. It affected all of the areas where Danish had been influential, including all of Denmark, Southern Sweden, and coastal southern Norway. In the 18th century, Danish philology was advanced by Rasmus Rask , who pioneered the disciplines of comparative and historical linguistics, and wrote
7567-584: The Atuagagdliutt , Greenland's first newspaper, with a native Greenlander as editor. This newspaper based in Nuuk later became an important token of Greenlandic identity. During World War II , there was a reawakening of Greenlandic national identity. The use of written Greenlandic grew, a council was assembled under Eske Brun 's leadership in Nuuk. In 1940, an American and a Canadian Consulate were established in Nuuk. Under new regulations in 1950, two councils amalgamated into one. This Countryside Council
7728-474: The Arctic Umiaq Line , which links the communities of the western coast. The majority of buses and cars owned in Greenland operate in Nuuk. There are no roads connecting Nuuk with other areas of Greenland. The main street in Nuuk is Aqqusinersuaq , with a number of shops and the 140-room Hotel Hans Egede . Since 2009, the city bus service Nuup Bussii provides city transport services in Nuuk for
7889-568: The Bible in Danish, the Bible of Christian II translated by Christiern Pedersen , was published in 1550. Pedersen's orthographic choices set the de facto standard for subsequent writing in Danish. From around 1500, several printing presses were in operation in Denmark publishing in Danish and other languages. In the period after 1550, presses in Copenhagen dominated the publication of material in
8050-698: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where
8211-570: The Late Middle Ages . Out of the 500 most frequently used Danish words, 100 are loans from Middle Low German; this is because Low German was the second official language of Denmark–Norway. In the 17th and 18th centuries, standard German and French superseded Low German influence, and in the 20th century, English became the main supplier of loanwords, especially after World War II . Although many old Nordic words remain, some were replaced with borrowed synonyms, for example æde (to eat)
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#17327718172148372-597: The New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred
8533-523: The Old Norse language ; Danish and Swedish are also classified as East Scandinavian or East Nordic languages. Scandinavian languages are often considered a dialect continuum , where no sharp dividing lines are seen between the different vernacular languages. Like Norwegian and Swedish, Danish was significantly influenced by Low German in the Middle Ages, and has been influenced by English since
8694-773: The Qilakitsoq mummies. Examples of modern architecture include the Katuaq cultural center by Schmidt Hammer Lassen (1997), the campus of the University of Greenland by Tegnestuen Nuuk and KHR Arkitekter (2008), the Nuuk Center by KHR Arkitekter (2012) and the Anstalten Correctional Facility by Friis & Moltke and Schmidt Hammer Lassen (2019). Katuaq is a cultural center used for concerts, films, art exhibitions, and conferences. It
8855-540: The Sermersooq municipality, linking the town center with the airport, the outlying districts and neighborhoods of Nuussuaq , Qinngorput , as well as Qernertunnguit in Quassussuup Tungaa . In 2012, the buses transported more than 2 million passengers around the city of Nuuk. Hans Egede's House , built in 1721 by the Norwegian missionary Hans Egede, is the oldest building in Greenland. Standing close to
9016-1091: The United States , Canada , Brazil , and Argentina . Along with the other North Germanic languages, Danish is a descendant of Old Norse , the common language of the Germanic peoples who lived in Scandinavia during the Viking Era . Danish, together with Swedish, derives from the East Norse dialect group , while the Middle Norwegian language (before the influence of Danish) and Norwegian Bokmål are classified as West Norse along with Faroese and Icelandic . A more recent classification based on mutual intelligibility separates modern spoken Danish, Norwegian , and Swedish as "mainland (or continental ) Scandinavian", while Icelandic and Faroese are classified as "insular Scandinavian". Although
9177-467: The Women's Party . KANUKOKA ( Greenlandic : Kalaallit Nunaanni Kommunit Kattuffiat ) was based in Nuuk. It was an association of Greenland's municipalities, led by Enok Sandgreen. The aim of the organisation was to facilitate cooperation among all five municipalities of Greenland: Avannaata , Kujalleq , Qeqertalik , Qeqqata , and Sermersooq. However, Sermersooq and Qeqertalik both withdrew and KANUKOKA
9338-544: The Zealand dialect Introductio ad lingvam Danicam puta selandicam ; and in 1685 the first Danish grammar written in Danish, Den Danske Sprog-Kunst ("The Art of the Danish Language") by Peder Syv . Major authors from this period are Thomas Kingo , poet and psalmist, and Leonora Christina Ulfeldt , whose novel Jammersminde ( Remembered Woes ) is considered a literary masterpiece by scholars. Orthography
9499-422: The common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15, the first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and
9660-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that
9821-402: The introduction of the printing press , a standard language was developed which was based on the educated dialect of Copenhagen and Malmö . It spread through use in the education system and administration, though German and Latin continued to be the most important written languages well into the 17th century. Following the loss of territory to Germany and Sweden, a nationalist movement adopted
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#17327718172149982-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of
10143-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses
10304-579: The 9th century with the younger futhark . Possibly as far back as the seventh century, the common Norse language began to undergo changes that did not spread to all of Scandinavia, resulting in the appearance of two dialect areas, Old West Norse ( Norway and Iceland ) and Old East Norse ( Denmark and Sweden ). Most of the changes separating East Norse from West Norse started as innovations in Denmark, that spread through Scania into Sweden and by maritime contact to southern Norway. A change that separated Old East Norse (Runic Swedish/Danish) from Old West Norse
10465-779: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,
10626-594: The Danish language, and also started a period of homogenization, whereby the Copenhagen standard language gradually displaced the regional vernacular languages. Throughout the 19th century, Danes emigrated, establishing small expatriate communities in the Americas, particularly in the United States, Canada, and Argentina, where memory and some use of Danish remains today. After the Schleswig referendum in 1920 ,
10787-517: The Danish language. Herrer og Narre have frit Sprog . "Lords and jesters have free speech." Peder Syv , proverbs Following the first Bible translation, the development of Danish as a written language , as a language of religion, administration, and public discourse accelerated. In the second half of the 17th century, grammarians elaborated grammars of Danish, first among them Rasmus Bartholin 's 1657 Latin grammar De studio lingvæ danicæ ; then Laurids Olufsen Kock 's 1660 grammar of
10948-407: The Danish tongue." Heimskringla by Snorri Sturluson By the eighth century, the common Germanic language of Scandinavia, Proto-Norse , had undergone some changes and evolved into Old Norse . This language was generally called the "Danish tongue" ( Dǫnsk tunga ), or "Norse language" ( Norrœnt mál ). Norse was written in the runic alphabet , first with the elder futhark and from
11109-518: The Lutheran Church of Denmark . Around 1850, Greenland, and especially the area around Nuuk, were in crisis. The Europeans had brought diseases and a culture that conflicted with the ways of the native Greenlanders. Many Greenlanders were living in poverty. In 1853, Hinrich Johannes Rink came to Greenland and was surprised at how local Greenlandic culture and identity had been suppressed under Danish influence. In response, in 1861, he started
11270-406: The Nordic countries have the opportunity to use their native language when interacting with official bodies in other Nordic countries without being liable for any interpretation or translation costs. Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus . The last naturally occurring case
11431-710: The Old Norse word for "island". This monophthongization started in Jutland and spread eastward, having spread throughout Denmark and most of Sweden by 1100. Through Danish conquest, Old East Norse was once widely spoken in the northeast counties of England . Many words derived from Norse, such as "gate" ( gade ) for street, still survive in Yorkshire , the East Midlands and East Anglia, and parts of eastern England colonized by Danish Vikings . The city of York
11592-770: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,
11753-565: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor
11914-601: The University of Greenland, is in Nuuk and is the national university of Greenland. Most courses are taught in Danish , although a few are in Kalaallisut as well. As of 2007, the university had approximately 150 students (almost all Greenlanders), around 14 academic staff, and five administrators. Its library holds approximately 30,000 volumes. The National Library of Greenland in Nuuk is the largest reference library in
12075-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add
12236-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing
12397-600: The area, eventually outnumbering the Danish speakers. The political loss of territory sparked a period of intense nationalism in Denmark, coinciding with the so-called " Golden Age " of Danish culture. Authors such as N.F.S. Grundtvig emphasized the role of language in creating national belonging. Some of the most cherished Danish-language authors of this period are existential philosopher Søren Kierkegaard and prolific fairy tale author Hans Christian Andersen . The influence of popular literary role models, together with increased requirements of education did much to strengthen
12558-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When
12719-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate
12880-516: The characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through the smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after
13041-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized
13202-406: The country, devoted to the preservation of Greenland's cultural heritage and history. The library holdings are split between the public library in the town center and Ilimmarfik, the campus of the University of Greenland. As of 1 January 2008, there are 83,324 items in the library database at Ilimmarfik. Nuuk's sports clubs include Nuuk IL (established in 1934), B-67 , and GSS Nuuk . Nuuk Stadium
13363-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as
13524-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly
13685-512: The disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It was one of several diseases introduced by the Columbian exchange to
13846-508: The exclusive use of rigsdansk , the High Copenhagen Standard, in national broadcasting, the traditional dialects came under increased pressure. In the 20th century, they have all but disappeared, and the standard language has extended throughout the country. Minor regional pronunciation variation of the standard language, sometimes called regionssprog ("regional languages") remain, and are in some cases vital. Today,
14007-451: The first English-language grammar of Danish. Literary Danish continued to develop with the works of Ludvig Holberg , whose plays and historical and scientific works laid the foundation for the Danish literary canon. With the Danish colonization of Greenland by Hans Egede , Danish became the administrative and religious language there, while Iceland and the Faroe Islands had the status of Danish colonies with Danish as an official language until
14168-448: The formal establishment of the mission as New Herrnhut ( Danish : Nye-Hernhut ). This became the nucleus for present-day Nuuk as many Greenlanders from the southeastern coast left their territory to live at the mission station. From this base, further missions were established at Lichtenfels (1748), Lichtenau (1774), Friedrichsthal (1824), Umanak (1861), and Idlorpait (1864), before they were discontinued in 1900 and folded into
14329-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to
14490-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox
14651-475: The harbor among other old houses, it is now used for government receptions. The Church of Our Saviour of the Lutheran diocese of Greenland was built in 1849, and the tower was added in 1884. The red building with a clock tower and steeple is a prominent site on the landscape. The church received the status of Nuuk Cathedral in 1994, when the first bishop was Kristian Mørk, followed in 1995 by Sofie Petersen,
14812-417: The highest percentage of aboriginal people of any city: almost 90% of Greenland's population of 58,000 is Inuit, and at least eight in 10 live in urban settlements. Nuuk also celebrates Inuit culture and history to an extent that is unprecedented in many cities with higher total aboriginal populations. By proportion and by cultural authority and impact, it may well be tiny Nuuk that is the most indigenous city in
14973-426: The history of Danish into a period from 800 AD to 1525 to be "Old Danish", which he subdivided into "Runic Danish" (800–1100), Early Middle Danish (1100–1350) and Late Middle Danish (1350–1525). Móðir Dyggva var Drótt, dóttir Danps konungs, sonar Rígs er fyrstr var konungr kallaðr á danska tungu . " Dyggvi 's mother was Drott, the daughter of king Danp, Ríg 's son, who was the first to be called king in
15134-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,
15295-424: The language as a token of Danish identity, and the language experienced a strong surge in use and popularity, with major works of literature produced in the 18th and 19th centuries. Today, traditional Danish dialects have all but disappeared, though regional variants of the standard language exist. The main differences in language are between generations, with youth language being particularly innovative. Danish has
15456-547: The language of the courts. Since 1997, public authorities have been obliged to follow the official spelling system laid out in the Orthography Law. In the 21st century, discussions have been held with a view to create a law that would make Danish the official language of Denmark. In addition, a noticeable community of Danish speakers is in Southern Schleswig , the portion of Germany bordering Denmark, and
15617-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after
15778-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in
15939-460: The main holdings of the Public and National Library of Greenland , are at the northern end of the district, near the road to Nuuk Airport . Nuuk receives its electric power mainly from the renewable energy-powered Buksefjord hydroelectric power plant by way of a 132 kV powerline crossing Ameralik fjord over a distance of 5,376 m (17,638 ft), the world's longest free span. The site has
16100-573: The mainland. At that time, Greenland was formally still a Norwegian colony ( until 1814 ) under the united Dano-Norwegian Crown , but the colony had not had any contact for over three centuries. Paarss's colonists consisted of mutinous soldiers, convicts, and prostitutes and most died within the first year of scurvy and other ailments. In 1733 and 1734, a smallpox epidemic killed most of the native population as well as Egede's wife. Hans Egede went back to Denmark in 1736 after 15 years in Greenland, leaving his son Poul to continue his work. Godthaab became
16261-407: The major varieties of Standard Danish are High Copenhagen Standard, associated with elderly, well to-do, and well educated people of the capital, and low Copenhagen speech traditionally associated with the working class, but today adopted as the prestige variety of the younger generations. Also, in the 21st century, the influence of immigration has had linguistic consequences, such as the emergence of
16422-408: The malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and the first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by
16583-422: The mid-20th century. Moders navn er vort Hjertesprog, kun løs er al fremmed Tale. Det alene i mund og bog, kan vække et folk af dvale. "Mother's name is our hearts' tongue, only idle is all foreign speech It alone, in mouth or in book, can rouse a people from sleep." N.F.S. Grundtvig , "Modersmaalet" Following the loss of Schleswig to Germany, a sharp influx of German speakers moved into
16744-480: The mountain Lille Malene, with the valley station close to the airport terminal. There is also the Nuuk golf course, the only arctic golf course in the world. Nuuk is twinned with: Danish language Nordic Council Danish ( / ˈ d eɪ n ɪ ʃ / , DAY -nish ; endonym : dansk pronounced [ˈtænˀsk] , dansk sprog [ˈtænˀsk ˈspʁɔwˀ] )
16905-481: The northeast of the town center. Built in 1979, it is a hub for Air Greenland , which is also headquartered in Nuuk and operates its technical base at the airport. There are flights inside Greenland and to Iceland. A decision has been made to extend the runway to allow for flights to European destinations, such as Denmark. Starting in summer 2024, Air Greenland and Canadian North airlines has an agreement with weekly flights between Nuuk and Iqaluit, Nunavut, Canada. As
17066-504: The northeast, reaching a height of 1,210 m (3,970 ft), Sermitsiaq can be seen from almost everywhere in Nuuk. The mountain has given its name to the nationwide newspaper Sermitsiaq . Closer to the town are the peaks of Store Malene , 790 m (2,590 ft), and Lille Malene , 420 m (1,380 ft). The magnetic declination at Nuuk is extreme. Nuuk has a maritime-influenced tundra climate ( Köppen ET ) with long, cold, snowy winters and short, cool summers. Although
17227-544: The northwest, to then turn southwest at 64°43′N 50°37′W / 64.717°N 50.617°W / 64.717; -50.617 , splitting into three arms in its lower run, with three big islands in between the arms: Sermitsiaq Island , Qeqertarsuaq Island , and Qoornuup Qeqertarsua . The fjord widens into a bay dotted with skerries near its mouth, opening into Labrador Sea at approximately 64°03′N 51°58′W / 64.050°N 51.967°W / 64.050; -51.967 . Some 20 km (12 mi) to
17388-577: The old colonial part of Nuuk ( Nuutoqaq : Old Nuuk). Other notable educational institutions include the Department of Nursing and Health Science, Nuuk Technical College and the Iron & Metal School. The city is served by Queen Ingrid's Health Center . The health center serves as the regional health center for Region Sermersooq. It has an emergency room, and a central clinic with several general practitioners . Nuuk also has Queen Ingrid's Hospital which
17549-415: The only university in Greenland, is in Nuuk. The university was founded in 1987 and expanded in 2007 with the new building, Ilimmarfik , housing departments of journalism, management and economics, language, literature and media, cultural and social history, theology and religion and social work. Nuuk is also home to the Department of Learning (Ilinniarfissuaq), the oldest educational facility in Greenland, in
17710-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox
17871-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox
18032-464: The other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of
18193-523: The outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series, the case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form,
18354-588: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of
18515-497: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because
18676-491: The prodromal illness still occurred but may have been less severe than in the ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)
18837-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before
18998-541: The seat of government for the Danish colony of South Greenland , while Godhavn (modern Qeqertarsuaq) was the capital of North Greenland until 1940, when the administration was unified in Godthaab. In 1733, Moravian missionaries received permission to begin a mission on the island; in 1747, there were enough converts to prompt the construction of the Moravian Brethren Mission House and
19159-479: The second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By the sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to
19320-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this
19481-472: The shared written standard language remained). With the introduction of absolutism in 1660, the Danish state was further integrated, and the language of the Danish chancellery, a Zealandic variety with German and French influence, became the de facto official standard language , especially in writing—this was the original so-called rigsdansk ("Danish of the Realm"). Also, beginning in the mid-18th century,
19642-427: The smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is a less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash)
19803-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There
19964-425: The temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to
20125-486: The three languages can often understand the others fairly well, though studies have shown that the mutual intelligibility is asymmetric: Norwegian speakers generally understand both Danish and Swedish far better than Swedes or Danes understand each other. Concomitantly, Swedes and Danes understand Norwegian better than they understand each other's languages. Norwegian occupies the middle position in terms of intelligibility because of its shared border with Sweden, resulting in
20286-411: The touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week, the pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced
20447-445: The turn of the 20th century. Danish itself can be divided into three main dialect areas: Jutlandic (West Danish), Insular Danish (including the standard variety), and East Danish (including Bornholmian and Scanian ). According to the view that Scandinavian is a dialect continuum, East Danish can be considered intermediary between Danish and Swedish, while Scanian can be considered a Swedified East Danish dialect, and Bornholmian
20608-411: The vernacular language to be accessible also to those who were not Latinate. The Jutlandic Law and Scanian Law were written in vernacular Danish in the early 13th century. Beginning in 1350, Danish began to be used as a language of administration, and new types of literature began to be written in the language, such as royal letters and testaments. The orthography in this period was not standardized nor
20769-469: The vernacular, such as the plural form of verbs, should be conserved in writing (i.e. han er "he is" vs. de ere "they are"). The East Danish provinces were lost to Sweden after the Second Treaty of Brömsebro (1645) after which they were gradually Swedified; just as Norway was politically severed from Denmark, beginning also a gradual end of Danish influence on Norwegian (influence through
20930-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on
21091-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox
21252-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in
21413-554: The whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on the Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and
21574-516: The whore-bed with another man's wife and he comes away alive..." Jutlandic Law, 1241 In the medieval period, Danish emerged as a separate language from Swedish. The main written language was Latin, and the few Danish-language texts preserved from this period are written in the Latin alphabet, although the runic alphabet seems to have lingered in popular usage in some areas. The main text types written in this period are laws, which were formulated in
21735-516: The winters in Nuuk are relatively cold, they are milder compared to other tundra climates, such as in Alaska in the United States or parts of Eastern Siberia . Instead, peak winter is similar to identical latitudes in the Nordic countries . On 21 December, the shortest day and longest night of the year, the sun rises at 11:22 am and sets at 3:28 pm. By contrast, on the longest day and shortest night of
21896-492: The word by , meaning ‘village’ or ‘town’, occurs in many English place-names, such as Whitby and Selby , as remnants of the Viking occupation . During that period English adopted ‘are’, the third person plural form of the verb ‘to be’, as well as the personal pronouns ‘they’, ‘them’ and ‘their’ from contemporary Old Norse. Danish is largely mutually intelligible with Norwegian and Swedish . A proficient speaker of any of
22057-503: The world's northernmost capital , only a few kilometres farther north than the Icelandic capital Reykjavík . When home rule was established in 1979, the authorization of place names was transferred to Greenlandic authorities, who subsequently preferred Greenlandic names over Danish ones. The name Godthåb mostly went out of use over the next two decades. The campus of the University of Greenland , hosting Statistics Greenland and
22218-527: The world. Nuuk is located at approximately 64°10′N 51°44′W / 64.167°N 51.733°W / 64.167; -51.733 at the mouth of Nuup Kangerlua (formerly Baal's River), some 10 km (6.2 mi) from the shores of the Labrador Sea on the southwestern coast of Greenland, and about 240 km (150 mi) south of the Arctic Circle . Initially, the fjord flows to
22379-489: The written languages are compatible, spoken Danish is distinctly different from Norwegian and Swedish and thus the degree of mutual intelligibility with either is variable between regions and speakers . Until the 16th century, Danish was a continuum of dialects spoken from Southern Jutland and Schleswig to Scania with no standard variety or spelling conventions. With the Protestant Reformation and
22540-633: The year, 21 June, the sun rises at 3:53 am and does not set until 1:03 am, producing constant civil twilight . Nuuk can have mild temperatures on brief occasions year-round, with each month having recorded 13 °C (55 °F) or warmer, although only June, July, August, and September have recorded what could be considered hot weather (defined as 22.5 °C (72.5 °F) or higher). The monthly averages range from −9 °C (16 °F) to 7 °C (45 °F), whereas all-time extremes range from −32.5 °C (−26.5 °F) on 14 January 1984 to 26.3 °C (79.3 °F) on 6 July 2008. The record wind in Nuuk
22701-492: Was a territory ruled by Denmark–Norway , one of whose official languages was Danish. Though Danish ceased to be an official language in Iceland in 1944, it is still widely used and is a mandatory subject in school, taught as a second foreign language after English. No law stipulates an official language for Denmark, making Danish the de facto official language only. The Code of Civil Procedure does, however, lay down Danish as
22862-629: Was abolished on 1 May 1979, when the city of Godthåb was renamed Nuuk by the Greenland Home Rule government. The city boomed during the 1950s when Denmark began to modernize Greenland. As in Greenland as a whole, Nuuk is populated today by both Inuit and Danes . Over a third of Greenland's total population lives in the Nuuk Greater Metropolitan area. An article examining indigenous influences on cities worldwide suggested, One city... stands out. Nuuk... has probably
23023-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of
23184-400: Was also one of two official languages of Greenland (alongside Greenlandic ). Danish now acts as a lingua franca in Greenland, with a large percentage of native Greenlanders able to speak Danish as a second language (it was introduced into the education system as a compulsory language in 1928). About 10% of the population speaks Danish as their first language , due to immigration. Iceland
23345-572: Was designed by Schmidt Hammer Lassen and inaugurated on 15 February 1997. Katuaq contains two auditoria , the larger seating 1,008 people and the smaller, 508. The complex also contains an art school, library, meeting facilities, administrative offices and a café. The Nuuk Art Museum is the only private art and crafts museum in Greenland. The museum contains a notable collection of local paintings, watercolors, drawings, and graphics, some by Andy Warhol; and figures in soapstone, ivory, and wood, with many items collected by archaeologists. Ilisimatusarfik,
23506-478: Was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash . Over a number of days, the skin rash turned into
23667-589: Was dissolved as of Tuesday, 31 July 2018. The organisation ran the municipal elections every four years, with the last election taking place in 2016. All municipal authorities in Greenland were members of the organisation until its 2018 dissolution. The association was overseen by Maliina Abelsen , the Minister for Social Affairs in the Government of Greenland. Although only a small town, Nuuk has developed trade, business, shipping and other industries. It began as
23828-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation
23989-406: Was later inhabited by Norse settlers from around 1000 AD until the disappearance of the settlement for uncertain reasons during the 15th century. ( Western Settlement ). The city proper was founded as the fort of Godt-Haab in 1728 by the royal governor Claus Paarss , when he relocated the missionary and merchant Hans Egede 's earlier Hope Colony ( Haabets Koloni ) from Kangeq Island to
24150-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from
24311-488: Was mostly supplanted by the Low German spise . As well as loanwords, new words can be freely formed by compounding existing words. In standard texts of contemporary Danish, Middle Low German loans account for about 16–17% of the vocabulary, Graeco-Latin loans 4–8%, French 2–4% and English about 1%. Danish and English are both Germanic languages. Danish is a North Germanic language descended from Old Norse, and English
24472-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox
24633-627: Was once the Viking settlement of Jorvik. Several other English words derive from Old East Norse, for example "knife" ( kniv ), "husband" ( husbond ), and "egg" ( æg ). The suffix "-by" for 'town' is common in place names in Yorkshire and the east Midlands, for example Selby, Whitby, Derby, and Grimsby. The word "dale" meaning valley is common in Yorkshire and Derbyshire placenames. Fangær man saar i hor seng mæth annæns mansz kunæ. oc kumær han burt liuænd... . "If one catches someone in
24794-638: Was part of the relocation. The new colony was placed at the Inuit settlement of Nûk and was named Godthaab ("Good Hope"). "Nuuk" is the Greenlandic word for " cape " ( Danish : næs ) and is commonly found in Greenlandic place names. It is so named because of its position at the end of the Nuup Kangerlua fjord on the eastern shore of the Labrador Sea . Its latitude , at 64°11' N, makes it
24955-456: Was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox, the malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and
25116-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout
25277-463: Was still not standardized and the principles for doing so were vigorously discussed among Danish philologists. The grammar of Jens Pedersen Høysgaard was the first to give a detailed analysis of Danish phonology and prosody, including a description of the stød . In this period, scholars were also discussing whether it was best to "write as one speaks" or to "speak as one writes", including whether archaic grammatical forms that had fallen out of use in
25438-469: Was the change of the diphthong æi (Old West Norse ei ) to the monophthong e , as in stæin to sten . This is reflected in runic inscriptions where the older read stain and the later stin . Also, a change of au as in dauðr into ø as in døðr occurred. This change is shown in runic inscriptions as a change from tauþr into tuþr . Moreover, the øy (Old West Norse ey ) diphthong changed into ø , as well, as in
25599-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it
25760-474: Was the spoken language, and the regional laws demonstrate the dialectal differences between the regions in which they were written. Throughout this period, Danish was in contact with Low German , and many Low German loan words were introduced in this period. With the Protestant Reformation in 1536, Danish also became the language of religion, which sparked a new interest in using Danish as
25921-516: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed
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