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146-613: Prince Grigory Grigoryevich Orlov ( Russian : Григорий Григорьевич Орлов ; 17 October 1734 – 24 April 1783) was a favourite of the Empress Catherine the Great of Russia , Prince of the Holy Roman Empire (1772), state and military figure, collector, patron of arts , and General-in-Chief . He patronised M. V. Lomonosov , D. I. Fonvisin , V. I. Bazhenov and gave them financial support. Honorary member of

292-674: A constitutional referendum on whether to adopt Russian as a second official language. According to the Central Election Commission, 74.8% voted against, 24.9% voted for and the voter turnout was 71.1%. Starting in 2019, instruction in Russian will be gradually discontinued in private colleges and universities in Latvia, and in general instruction in Latvian public high schools. On 29 September 2022, Saeima passed in

438-410: A marker gene . This gene, called GFP , or green fluorescent protein, would cause live samples of the virus to glow green under fluorescent light. The insertion of this gene, which would not influence the virulence of the virus, would be the only allowed modification of the genome. The committee stated the proposed modification would aid in research of treatments by making it easier to assess whether

584-519: A new education law which requires all schools to teach at least partially in Ukrainian, with provisions while allow indigenous languages and languages of national minorities to be used alongside the national language. The law faced criticism from officials in Russia and Hungary. The 2019 Law of Ukraine "On protecting the functioning of the Ukrainian language as the state language" gives priority to

730-443: A clinical case was observed, smallpox was confirmed using laboratory tests. Microscopically , poxviruses produce characteristic cytoplasmic inclusion bodies , the most important of which are known as Guarnieri bodies , and are the sites of viral replication . Guarnieri bodies are readily identified in skin biopsies stained with hematoxylin and eosin, and appear as pink blobs. They are found in virtually all poxvirus infections but

876-553: A coup against Peter in the first two seasons, before Catherine and Peter reconcile and Catherine unknowingly kills Orlo in the third-season premiere, shooting him while hunting in the forest with Peter. [REDACTED] Media related to Grigoriy Orlov at Wikimedia Commons Russian language Russian is an East Slavic language belonging to the Balto-Slavic branch of the Indo-European language family . It

1022-415: A discrete rash, in which the pustules stood out on the skin separately. The distribution of the rash was most dense on the face, denser on the extremities than on the trunk, and denser on the distal parts of the extremities than on the proximal. The palms of the hands and soles of the feet were involved in most cases. Sometimes, the blisters merged into sheets, forming a confluent rash, which began to detach

1168-518: A doctor in Berkeley, Gloucestershire , rural England, discovered that immunity to smallpox could be produced by inoculating a person with material from a cowpox lesion. Cowpox is a poxvirus in the same family as variola. Jenner called the material used for inoculation vaccine from the root word vacca , which is Latin for cow. The procedure was much safer than variolation and did not involve a risk of smallpox transmission. Vaccination to prevent smallpox

1314-448: A fairly accurate appreciation of current events, and was a useful and sympathetic counselor during the earlier portion of Catherine's reign. He entered with enthusiasm, from both patriotic and economic motives, into the question of the improvement of the condition of the serfs and their partial emancipation. He also led the investigation of Lieutenant Vasily Mirovich , who tried to free the former Russian Emperor Ivan VI Antonovich from

1460-455: A fatality rate of around 30%, while variola minor’s mortality rate was about 1%. Throughout the 18th century, variola major was responsible for around 400,000 deaths annually in Europe alone. Survivors of the disease often faced lifelong consequences, such as blindness and severe scarring, which were nearly universal among those who recovered. In the first half of the 20th century, variola major

1606-709: A few months prior to his death in Moscow in 1783. In 1777, at the age of 43, he married his 18-year-old relative, Catherine Zinovyeva , variously described by sources as either a niece or a cousin, but left no children by that marriage. Catherine died of tuberculosis in 1781, at the age of 22, in Lausanne, Switzerland . Her tomb, from which her body was removed in 1910, still remains in Cathedrale Notre-Dame in Lausanne. For some time before his death, he had

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1752-576: A formula with V standing for the nucleus (vowel) and C for each consonant, the maximal structure can be described as follows: (C)(C)(C)(C)V(C)(C)(C)(C) Smallpox Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus . The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified

1898-558: A hard or soft counterpart, and the distinction is a prominent feature of the language, which is usually shown in writing not by a change of the consonant but rather by changing the following vowel. Another important aspect is the reduction of unstressed vowels . Stress , which is often unpredictable, is not normally indicated orthographically , though an optional acute accent may be used to mark stress – such as to distinguish between homographic words (e.g. замо́к [ zamók , 'lock'] and за́мок [ zámok , 'castle']), or to indicate

2044-614: A host cell varies across the poxviridae . Recombination of the genome occurs within actively infected cells. Following the onset of viral DNA replication, an intermediate set of genes codes for transcription factors of late gene expression. The products of the later genes include transcription factors necessary for transcribing the early genes for new virions, as well as viral RNA polymerase and other essential enzymes for new viral particles. These proteins are then packaged into new infectious virions capable of infecting other cells. Two live samples of variola major virus remain, one in

2190-484: A language that "belongs to the European cultural space". The financing of Russian-language content by the state will cease, which the concept says create a "unified information space". However, one inevitable consequence would be the closure of public media broadcasts in Russian on LTV and Latvian Radio, as well as the closure of LSM's Russian-language service. In Lithuania , Russian has no official or legal status, but

2336-486: A lesser extent in the Baltic states and Israel . Russian has over 258 million total speakers worldwide. It is the most spoken native language in Europe , the most spoken Slavic language , as well as the most geographically widespread language of Eurasia . It is the world's seventh-most spoken language by number of native speakers , and the world's ninth-most spoken language by total number of speakers . Russian

2482-588: A lesser extent the languages to the south and the east: Uralic , Turkic , Persian , Arabic , and Hebrew . According to the Defense Language Institute in Monterey, California , Russian is classified as a level III language in terms of learning difficulty for native English speakers, requiring approximately 1,100 hours of immersion instruction to achieve intermediate fluency. Feudal divisions and conflicts created obstacles between

2628-622: A minority language under the Framework Convention for the Protection of National Minorities . 30% of the population was fluent in Russian in 2006, and 2% used it as the main language with family, friends, or at work. In Azerbaijan , Russian has no official status, but is a lingua franca of the country. 26% of the population was fluent in Russian in 2006, and 5% used it as the main language with family, friends, or at work. In Georgia , Russian has no official status, but it

2774-601: A potential treatment was effective in killing viral samples. The recommendation could only take effect if approved by the WHA . When the WHA discussed the proposal in 2005, it refrained from taking a formal vote on the proposal, stating that it would review individual research proposals one at a time. Addition of the GFP gene to the Vaccinia genome is routinely performed during research on

2920-526: A qualitatively new entity can be said to emerge—the general language of the working class... capitalism has the tendency of creating the general urban language of a given society. In 2010, there were 259.8 million speakers of Russian in the world: in Russia – 137.5 million, in the CIS and Baltic countries – 93.7 million, in Eastern Europe – 12.9 million, Western Europe – 7.3 million, Asia – 2.7 million, in

3066-423: A region of roughly 100 base pairs necessary for resolving concatomeric DNA (a stretch of DNA containing multiple copies of the same sequence), a few open reading frames , and short tandemly repeating sequences of varying number and length. The ITRs of poxviridae vary in length across strains and species. The coding sequence for most of the viral proteins in variola major virus have at least 90% similarity with

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3212-629: A serious mental illness , probably a form of dementia , which progressed towards complete mental collapse. After his death, the Empress Catherine wrote, "Although I have long been prepared for this sad event, it has nevertheless shaken me to the depths of my being. People may console me, I may even repeat to myself all those things which it is customary to say on such occasions—my only answer is strangled tears. I suffer intolerably." From 2020 to 2023, Gwilym Lee and Sacha Dhawan starred as two separate fictionalised versions of Grigory Orlov in

3358-421: A source of infection”; noted that “Current recommendations for control of secondary smallpox infections emphasize transmission ‘by expelled droplets to close contacts (those within 6–7 feet)’”; but warned that the “emphasis on spread via large droplets may reduce the vigilance with which more difficult airborne precautions [i.e. against finer droplets capable of traveling longer distances and penetrating deeply into

3504-602: A year. The final known fatal case occurred in the United Kingdom in 1978 . Inoculation for smallpox appears to have started in China around the 1500s. Europe adopted this practice from Asia in the first half of the 18th century. In 1796, Edward Jenner introduced the modern smallpox vaccine. In 1967, the WHO intensified efforts to eliminate the disease. Smallpox is one of two infectious diseases to have been eradicated,

3650-535: A younger brother Alexei Grigoryevich Orlov who would equally gain military and political prominence in Russia. Grigory Orlov was educated in the corps of cadets at Saint Petersburg , began his military career in the Seven Years' War , and was wounded at Zorndorf . In the late 1750s, according to Andrey Bolotov , he was initiated into the Freemasons . While serving in the capital as an artillery officer in

3796-539: Is Belarusian, among ethnic Belarusians this share is 28.5%; the highest share of those who speak Belarusian at home is among ethnic Poles — 46.0%. In Estonia , Russian is spoken by 29.6% of the population, according to a 2011 estimate from the World Factbook, and is officially considered a foreign language. School education in the Russian language is a very contentious point in Estonian politics, and in 2022,

3942-481: Is a co-official language per article 5 of the Constitution of Kyrgyzstan . The 2009 census states that 482,200 people speak Russian as a native language, or 8.99% of the population. Additionally, 1,854,700 residents of Kyrgyzstan aged 15 and above fluently speak Russian as a second language, or 49.6% of the population in the age group. In Tajikistan , Russian is the language of inter-ethnic communication under

4088-401: Is a high degree of mutual intelligibility between Russian, Belarusian and Ukrainian , and a moderate degree of it in all modern Slavic languages, at least at the conversational level. Russian is written using a Cyrillic alphabet. The Russian alphabet consists of 33 letters. The following table gives their forms, along with IPA values for each letter's typical sound: Older letters of

4234-610: Is a post-posed definite article -to , -ta , -te similar to that existing in Bulgarian and Macedonian. In the Southern Russian dialects , instances of unstressed /e/ and /a/ following palatalized consonants and preceding a stressed syllable are not reduced to [ɪ] (as occurs in the Moscow dialect), being instead pronounced [a] in such positions (e.g. несл и is pronounced [nʲaˈslʲi] , not [nʲɪsˈlʲi] ) – this

4380-582: Is a severe form accompanied by extensive bleeding into the skin, mucous membranes, gastrointestinal tract, and viscera . This form develops in approximately 2% of infections and occurs mostly in adults. Pustules do not typically form in hemorrhagic smallpox. Instead, bleeding occurs under the skin, making it look charred and black, hence this form of the disease is also referred to as variola nigra or "black pox". Hemorrhagic smallpox has very rarely been caused by variola minor virus. While bleeding may occur in mild cases and not affect outcomes, hemorrhagic smallpox

4526-420: Is also a later form of hemorrhagic smallpox (referred to late hemorrhagic smallpox, or variolosa pustula hemorrhagica ). The prodrome is severe and similar to that observed in early hemorrhagic smallpox, and the fever persists throughout the course of the disease. Bleeding appears in the early eruptive period (but later than that seen in purpura variolosa ), and the rash is often flat and does not progress beyond

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4672-490: Is also under research as a viral vector for vaccines for unrelated diseases. The genome of variola major virus was first sequenced in its entirety in the 1990s. The complete coding sequence is publicly available online. The current reference sequence for variola major virus was sequenced from a strain that circulated in India in 1967. In addition, there are sequences for samples of other strains that were collected during

4818-488: Is being used less frequently by Russian-speaking typists in favor of the extension of Unicode character encoding , which fully incorporates the Russian alphabet. Free programs are available offering this Unicode extension, which allow users to type Russian characters, even on Western 'QWERTY' keyboards. The Russian language was first introduced to computing after the M-1 , and MESM models were produced in 1951. According to

4964-541: Is believed to have had a mortality rate of less than 1%, as compared to variola major's 30%. Like variola major, variola minor was spread through inhalation of the virus in the air, which could occur through face-to-face contact or through fomites. Infection with variola minor virus conferred immunity against the more dangerous variola major virus. Because variola minor was a less debilitating disease than smallpox, people were more frequently ambulant and thus able to infect others more rapidly. As such, variola minor swept through

5110-624: Is called yakanye ( яканье ). Consonants include a fricative /ɣ/ , a semivowel /w⁓u̯/ and /x⁓xv⁓xw/ , whereas the Standard and Northern dialects have the consonants /ɡ/ , /v/ , and final /l/ and /f/ , respectively. The morphology features a palatalized final /tʲ/ in 3rd person forms of verbs (this is unpalatalized in the Standard and Northern dialects). During the Proto-Slavic (Common Slavic) times all Slavs spoke one mutually intelligible language or group of dialects. There

5256-411: Is caused by infection with variola virus, which belongs to the family Poxviridae , subfamily Chordopoxvirinae , genus Orthopoxvirus . The date of the appearance of smallpox is not settled. It most probably evolved from a terrestrial African rodent virus between 68,000 and 16,000 years ago. The wide range of dates is due to the different records used to calibrate the molecular clock . One clade

5402-488: Is complicated by having multiple infectious forms, with differing mechanisms of cell entry. Poxviruses are unique among human DNA viruses in that they replicate in the cytoplasm of the cell rather than in the nucleus . To replicate, poxviruses produce a variety of specialized proteins not produced by other DNA viruses , the most important of which is a viral-associated DNA-dependent RNA polymerase . Both enveloped and unenveloped virions are infectious. The viral envelope

5548-447: Is consistent with the other published estimates, it suggests that the archaeological and historical evidence is very incomplete. Better estimates of mutation rates in these viruses are needed. Examination of a strain that dates from c.  1650 found that this strain was basal to the other presently sequenced strains. The mutation rate of this virus is well modeled by a molecular clock. Diversification of strains only occurred in

5694-441: Is estimated that 400,000 people died from the disease per year, and that one-third of all cases of blindness were due to smallpox. Smallpox is estimated to have killed up to 300 million people in the 20th century and around 500 million people in the last 100 years of its existence. Earlier deaths included six European monarchs , including Louis XV of France in 1774. As recently as 1967, 15 million cases occurred

5840-415: Is made of modified Golgi membranes containing viral-specific polypeptides, including hemagglutinin . Infection with either variola major virus or variola minor virus confers immunity against the other. The more common, infectious form of the disease was caused by the variola major virus strain, known for its significantly higher mortality rate compared to its counterpart, variola minor. Variola major had

5986-573: Is more spoken than English. Sizable Russian-speaking communities also exist in North America, especially in large urban centers of the US and Canada, such as New York City , Philadelphia , Boston , Los Angeles , Nashville , San Francisco , Seattle , Spokane , Toronto , Calgary , Baltimore , Miami , Portland , Chicago , Denver , and Cleveland . In a number of locations they issue their own newspapers, and live in ethnic enclaves (especially

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6132-564: Is odd") – чу́дно ( chúdno – "this is marvellous"), молоде́ц ( molodéts – "well done!") – мо́лодец ( mólodets – "fine young man"), узна́ю ( uznáyu – "I shall learn it") – узнаю́ ( uznayú – "I recognize it"), отреза́ть ( otrezát – "to be cutting") – отре́зать ( otrézat – "to have cut"); to indicate the proper pronunciation of uncommon words, especially personal and family names, like афе́ра ( aféra , "scandal, affair"), гу́ру ( gúru , "guru"), Гарси́я ( García ), Оле́ша ( Olésha ), Фе́рми ( Fermi ), and to show which

6278-657: Is one of the four extant East Slavic languages, and is the native language of the Russians . It was the de facto and de jure official language of the former Soviet Union . Russian has remained an official language of the Russian Federation , Belarus , Kazakhstan , Kyrgyzstan , and Tajikistan , and is still commonly used as a lingua franca in Ukraine , Moldova , the Caucasus , Central Asia , and to

6424-762: Is one of two official languages aboard the International Space Station , one of the six official languages of the United Nations , as well as the fourth most widely used language on the Internet . Russian is written using the Russian alphabet of the Cyrillic script ; it distinguishes between consonant phonemes with palatal secondary articulation and those without—the so-called "soft" and "hard" sounds. Almost every consonant has

6570-493: Is rapidly followed by the development of petechiae and bleeding in the skin, conjunctiva and mucous membranes. Death often occurs suddenly between the fifth and seventh days of illness, when only a few insignificant skin lesions are present. Some people survive a few days longer, during which time the skin detaches and fluid accumulates under it, rupturing at the slightest injury. People are usually conscious until death or shortly before. Autopsy reveals petechiae and bleeding in

6716-402: Is recognized as a minority language under the Framework Convention for the Protection of National Minorities . Russian is the language of 9% of the population according to the World Factbook. Ethnologue cites Russian as the country's de facto working language. In China , Russian has no official status, but it is spoken by the small Russian communities in the northeastern Heilongjiang and

6862-569: Is sometimes considered to have played a significant role in the formation of modern Russian. Also, Russian has notable lexical similarities with Bulgarian due to a common Church Slavonic influence on both languages, but because of later interaction in the 19th and 20th centuries, Bulgarian grammar differs markedly from Russian. Over the course of centuries, the vocabulary and literary style of Russian have also been influenced by Western and Central European languages such as Greek, Latin , Polish , Dutch , German, French, Italian, and English, and to

7008-585: Is spoken by 14.2% of the population according to an undated estimate from the World Factbook. In 2005, Russian was the most widely taught foreign language in Mongolia, and was compulsory in Year 7 onward as a second foreign language in 2006. Around 1.5 million Israelis spoke Russian as of 2017. The Israeli press and websites regularly publish material in Russian and there are Russian newspapers, television stations, schools, and social media outlets based in

7154-518: Is the stressed word in a sentence, for example Ты́ съел печенье? ( Tý syel pechenye? – "Was it you who ate the cookie?") – Ты съе́л печенье? ( Ty syél pechenye? – "Did you eat the cookie?) – Ты съел пече́нье? ( Ty syel pechénye? "Was it the cookie you ate?"). Stress marks are mandatory in lexical dictionaries and books for children or Russian learners. The Russian syllable structure can be quite complex, with both initial and final consonant clusters of up to four consecutive sounds. Using

7300-453: Is typically fatal. Vaccination does not appear to provide any immunity to either form of hemorrhagic smallpox and some cases even occurred among people that were revaccinated shortly before. It has two forms. The early or fulminant form of hemorrhagic smallpox (referred to as purpura variolosa ) begins with a prodromal phase characterized by a high fever, severe headache, and abdominal pain. The skin becomes dusky and erythematous, and this

7446-470: The 2011 Lithuanian census , Russian was the native language for 7.2% of the population. In Moldova , Russian was considered to be the language of interethnic communication under a Soviet-era law. On 21 January 2021, the Constitutional Court of Moldova declared the law unconstitutional and deprived Russian of the status of the language of interethnic communication. 50% of the population

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7592-1000: The Apollo–Soyuz mission, which first flew in 1975. In March 2013, Russian was found to be the second-most used language on websites after English. Russian was the language of 5.9% of all websites, slightly ahead of German and far behind English (54.7%). Russian was used not only on 89.8% of .ru sites, but also on 88.7% of sites with the former Soviet Union domain .su . Websites in former Soviet Union member states also used high levels of Russian: 79.0% in Ukraine, 86.9% in Belarus, 84.0% in Kazakhstan, 79.6% in Uzbekistan, 75.9% in Kyrgyzstan and 81.8% in Tajikistan. However, Russian

7738-413: The Constitution of Tajikistan and is permitted in official documentation. 28% of the population was fluent in Russian in 2006, and 7% used it as the main language with family, friends or at work. The World Factbook notes that Russian is widely used in government and business. In Turkmenistan , Russian lost its status as the official lingua franca in 1996. Among 12% of the population who grew up in

7884-698: The East India Company stationed in China and another by Clopton Havers . Lady Mary Wortley Montagu observed smallpox inoculation during her stay in the Ottoman Empire , writing detailed accounts of the practice in her letters, and enthusiastically promoted the procedure in England upon her return in 1718. According to Voltaire (1742), the Turks derived their use of inoculation from neighbouring Circassia . Voltaire does not speculate on where

8030-599: The Imperial Academy of Arts (since 1765). He collected paintings (including Rembrandt , P. P. Rubens , Titian ), sculpture, Chinese, Japanese and Russian porcelain, hunting weapons, etc. (Orlov's collection has been preserved almost completely; it is now in the State Museum-Reserve "Gatchina" of the eponymous city ). A large landowner, particularly of the Gatchina manor, where Orlov commissioned

8176-557: The Shlisselburg Fortress (1764). As the president of the Free Economic Society , he was also their most prominent advocate in the great commission of 1767 , though he aimed primarily at pleasing the empress, who affected great liberality in her earlier years. He promoted smallpox inoculation and was one of the first in Russia to inoculate against smallpox together with Empress Catherine II in 1768. He

8322-584: The Ukrainian language in more than 30 spheres of public life: in particular in public administration , media, education, science, culture, advertising, services . The law does not regulate private communication. A poll conducted in March 2022 by RATING in the territory controlled by Ukraine found that 83% of the respondents believe that Ukrainian should be the only state language of Ukraine. This opinion dominates in all macro-regions, age and language groups. On

8468-641: The United States Census , in 2007 Russian was the primary language spoken in the homes of over 850,000 individuals living in the United States. Russian is one of the official languages (or has similar status and interpretation must be provided into Russian) of the following: The Russian language is also one of two official languages aboard the International Space Station – NASA astronauts who serve alongside Russian cosmonauts usually take Russian language courses. This practice goes back to

8614-631: The alternate historical and satirical comedy - drama Hulu / Disney+ television series The Great: An Occasionally True Story / An Almost Entirely Untrue Story , with Lee portraying Grigory " Grigor " Dymov (a composite character with Grigory Potemkin ), the childhood best friend of Peter who grows close with his widow Catherine after both witness him accidentally drown in the third season, growing estranged from his wife Georgina and lover Marial in favor of caring for Catherine and her and Peter's son Paul , and Dhawan portraying Count Orlo , an advisor of Catherine's with whom she initially plans

8760-422: The common cold : fever of at least 38.3 °C (101 °F), muscle pain , malaise , headache and fatigue. As the digestive tract was commonly involved, nausea, vomiting, and backache often occurred. The early prodromal stage usually lasted 2–4 days. By days 12–15, the first visible lesions – small reddish spots called enanthem – appeared on mucous membranes of the mouth, tongue, palate , and throat, and

8906-460: The global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date. The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash . Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease

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9052-470: The horsepox virus using publicly available sequence data for horsepox. The researchers argued that their work would be beneficial to creating a safer and more effective vaccine for smallpox, although an effective vaccine is already available. The horsepox virus had previously seemed to have gone extinct, raising concern about potential revival of variola major and causing other scientists to question their motives. Critics found it especially concerning that

9198-468: The replication of viral DNA. The first set of expressed genes are transcribed by pre-existing viral machinery packaged within the infecting virion. These genes encode the factors necessary for viral DNA synthesis and for transcription of the next set of expressed genes. Unlike most DNA viruses, DNA replication in variola virus and other poxviruses takes place within the cytoplasm of the infected cell. The exact timing of DNA replication after infection of

9344-624: The 18th and 19th centuries. Variola virus is large and brick-shaped and is approximately 302 to 350 nanometers by 244 to 270 nm, with a single linear double stranded DNA genome 186 kilobase pairs (kbp) in size and containing a hairpin loop at each end. Four orthopoxviruses cause infection in humans: variola, vaccinia , cowpox , and monkeypox . Variola virus infects only humans in nature, although primates and other animals have been infected in an experimental setting. Vaccinia, cowpox, and monkeypox viruses can infect both humans and other animals in nature. The life cycle of poxviruses

9490-519: The 20th century, Russian was a mandatory language taught in the schools of the members of the old Warsaw Pact and in other countries that used to be satellites of the USSR. According to the Eurobarometer 2005 survey, fluency in Russian remains fairly high (20–40%) in some countries, in particular former Warsaw Pact countries. In Armenia , Russian has no official status, but it is recognized as

9636-471: The Belarusian society the Russian language prevails, so according to the 2019 census 6,718,557 people (71.4% of the total population) stated that they speak Russian at home, for ethnic Belarusians this share is 61.4%, for Russians — 97.2%, for Ukrainians — 89.0%, for Poles — 52.4%, and for Jews — 96.6%; 2,447,764 people (26.0% of the total population) stated that the language they usually speak at home

9782-727: The Circassians derived their technique from, though he reports that the Chinese have practiced it "these hundred years". In 1721, Cotton Mather and colleagues provoked controversy in Boston by inoculating hundreds. After publishing The present method of inoculating for the small-pox in 1767, Dr Thomas Dimsdale was invited to Russia to variolate the Empress Catherine the Great of Russia and her son, Grand Duke Paul , which he successfully did in 1768. In 1796, Edward Jenner ,

9928-480: The Great and developed from the Moscow ( Middle or Central Russian ) dialect substratum under the influence of some of the previous century's Russian chancery language. Prior to the Bolshevik Revolution , the spoken form of the Russian language was that of the nobility and the urban bourgeoisie. Russian peasants, the great majority of the population, continued to speak in their own dialects. However,

10074-590: The Institute of Russian Language of the Russian Academy of Sciences, an optional acute accent ( знак ударения ) may, and sometimes should, be used to mark stress . For example, it is used to distinguish between otherwise identical words, especially when context does not make it obvious: замо́к ( zamók – "lock") – за́мок ( zámok – "castle"), сто́ящий ( stóyashchy – "worthwhile") – стоя́щий ( stoyáshchy – "standing"), чудно́ ( chudnó – "this

10220-526: The Middle East and North Africa – 1.3 million, Sub-Saharan Africa – 0.1 million, Latin America – 0.2 million, U.S., Canada , Australia, and New Zealand – 4.1 million speakers. Therefore, the Russian language is the seventh-largest in the world by the number of speakers , after English, Mandarin, Hindi -Urdu, Spanish, French, Arabic, and Portuguese. Russian is one of the six official languages of

10366-807: The Russian alphabet include ⟨ ѣ ⟩ , which merged to ⟨ е ⟩ ( /je/ or /ʲe/ ); ⟨ і ⟩ and ⟨ ѵ ⟩ , which both merged to ⟨ и ⟩ ( /i/ ); ⟨ ѳ ⟩ , which merged to ⟨ ф ⟩ ( /f/ ); ⟨ ѫ ⟩ , which merged to ⟨ у ⟩ ( /u/ ); ⟨ ѭ ⟩ , which merged to ⟨ ю ⟩ ( /ju/ or /ʲu/ ); and ⟨ ѧ ⟩ and ⟨ ѩ ⟩ , which later were graphically reshaped into ⟨ я ⟩ and merged phonetically to /ja/ or /ʲa/ . While these older letters have been abandoned at one time or another, they may be used in this and related articles. The yers ⟨ ъ ⟩ and ⟨ ь ⟩ originally indicated

10512-458: The Russian principalities before and especially during Mongol rule. This strengthened dialectal differences, and for a while, prevented the emergence of a standardized national language. The formation of the unified and centralized Russian state in the 15th and 16th centuries, and the gradual re-emergence of a common political, economic, and cultural space created the need for a common standard language. The initial impulse for standardization came from

10658-458: The Soviet era can speak Russian, other generations of citizens that do not have any knowledge of Russian. Primary and secondary education by Russian is almost non-existent. In Uzbekistan , Russian is the language of inter-ethnic communication. It has some official roles, being permitted in official documentation and is the lingua franca of the country and the language of the elite. Russian

10804-403: The United Nations. Education in Russian is still a popular choice for both Russian as a second language (RSL) and native speakers in Russia, and in many former Soviet republics. Russian is still seen as an important language for children to learn in most of the former Soviet republics. In Belarus , Russian is a second state language alongside Belarusian per the Constitution of Belarus . 77% of

10950-770: The United States at the CDC in Atlanta, and one at the Vector Institute in Koltsovo, Russia. Research with the remaining virus samples is tightly controlled, and each research proposal must be approved by the WHO and the World Health Assembly (WHA). Most research on poxviruses is performed using the closely related Vaccinia virus as a model organism. Vaccinia virus, which is used to vaccinate for smallpox,

11096-510: The United States, Great Britain, and South Africa in the early 20th century, becoming the dominant form of the disease in those areas and thus rapidly decreasing mortality rates. Along with variola major, the minor form has now been totally eradicated from the globe. The last case of indigenous variola minor was reported in a Somali cook, Ali Maow Maalin, in October 1977, and smallpox was officially declared eradicated worldwide in May 1980. Variola minor

11242-531: The WHO eradication campaign. A genome browser for a complete database of annotated sequences of variola virus and other poxviruses is publicly available through the Viral Bioinformatics Resource Center . The WHO currently bans genetic engineering of the variola virus. However, in 2004, a committee advisory to the WHO voted in favor of allowing editing of the genome of the two remaining samples of variola major virus to add

11388-507: The absence of Guarnieri bodies could not be used to rule out smallpox. The diagnosis of an orthopoxvirus infection can also be made rapidly by electron microscopic examination of pustular fluid or scabs. All orthopoxviruses exhibit identical brick-shaped virions by electron microscopy. If particles with the characteristic morphology of herpesviruses are seen this will eliminate smallpox and other orthopoxvirus infections. Definitive laboratory identification of variola virus involved growing

11534-448: The bloodstream in large numbers, a condition known as viremia . This resulted in the second wave of multiplication in the spleen , bone marrow , and lymph nodes. The clinical definition of ordinary smallpox is an illness with acute onset of fever equal to or greater than 38.3 °C (101 °F) followed by a rash characterized by firm, deep-seated vesicles or pustules in the same stage of development without other apparent cause. When

11680-403: The broader sense of expanding the use of Russian alongside or in favour of other languages. The current standard form of Russian is generally regarded as the modern Russian literary language ( современный русский литературный язык – "sovremenny russky literaturny yazyk"). It arose at the beginning of the 18th century with the modernization reforms of the Russian state under the rule of Peter

11826-477: The central region of the genome is highly consistent across orthopoxviruses , and the arrangement of genes is consistent across chordopoxviruses. The center of the variola virus genome contains the majority of the essential viral genes, including the genes for structural proteins , DNA replication , transcription , and mRNA synthesis. The ends of the genome vary more across strains and species of orthopoxviruses . These regions contain proteins that modulate

11972-503: The closely related Vaccinia virus . The public availability of the variola virus complete sequence has raised concerns about the possibility of illicit synthesis of infectious virus. Vaccinia , a cousin of the variola virus, was artificially synthesized in 2002 by NIH scientists. They used a previously established method that involved using a recombinant viral genome to create a self-replicating bacterial plasmid that produced viral particles. In 2016, another group synthesized

12118-421: The construction of a palace and a landscape garden . He became a leader of the 1762 coup which overthrew Catherine's husband Peter III of Russia and installed Catherine as empress. For some years he was virtually co-ruler with her, but his repeated infidelities and the enmity of Catherine's other advisers led to his fall from power. Orlov was the son of Gregory Orlov , governor of Great Novgorod . He had

12264-572: The country. There is an Israeli TV channel mainly broadcasting in Russian with Israel Plus . See also Russian language in Israel . Russian is also spoken as a second language by a small number of people in Afghanistan . In Vietnam , Russian has been added in the elementary curriculum along with Chinese and Japanese and were named as "first foreign languages" for Vietnamese students to learn, on equal footing with English. The Russian language

12410-621: The course of the illness, but this happened most frequently during the first week of the rash when most of the skin lesions were intact. Infectivity waned in 7 to 10 days when scabs formed over the lesions, but the infected person was contagious until the last smallpox scab fell off. Concern about possible use of smallpox for biological warfare led in 2002 to Donald K. Milton's detailed review of existing research on its transmission and of then-current recommendations for controlling its spread. He agreed, citing Rao, Fenner and others, that “careful epidemiologic investigation rarely implicated fomites as

12556-403: The diagnosis of infection. Chickenpox was commonly confused with smallpox in the immediate post-eradication era. Chickenpox and smallpox could be distinguished by several methods. Unlike smallpox, chickenpox does not usually affect the palms and soles. Additionally, chickenpox pustules are of varying size due to variations in the timing of pustule eruption: smallpox pustules are all very nearly

12702-413: The factory and the industrial plant their local peasant dialects with their phonetics, grammar, and vocabulary, and the very process of recruiting workers from peasants and the mobility of the worker population generate another process: the liquidation of peasant inheritance by way of leveling the particulars of local dialects. On the ruins of peasant multilingual, in the context of developing heavy industry,

12848-456: The final reading amendments that state that all schools and kindergartens in the country are to transition to education in Latvian . From 2025, all children will be taught in Latvian only. On 28 September 2023, Latvian deputies approved The National Security Concept, according to which from 1 January 2026, all content created by Latvian public media (including LSM ) should be only in Latvian or

12994-692: The generation of immigrants who started arriving in the early 1960s). Only about 25% of them are ethnic Russians, however. Before the dissolution of the Soviet Union , the overwhelming majority of Russophones in Brighton Beach, Brooklyn in New York City were Russian-speaking Jews. Afterward, the influx from the countries of the former Soviet Union changed the statistics somewhat, with ethnic Russians and Ukrainians immigrating along with some more Russian Jews and Central Asians. According to

13140-408: The genome of vaccinia , a related virus used for vaccination against smallpox. Gene expression of variola virus occurs entirely within the cytoplasm of the host cell , and follows a distinct progression during infection. After entry of an infectious virion into a host cell, synthesis of viral mRNA can be detected within 20 minutes. About half of the viral genome is transcribed prior to

13286-480: The government bureaucracy for the lack of a reliable tool of communication in administrative, legal, and judicial affairs became an obvious practical problem. The earliest attempts at standardizing Russian were made based on the so-called Moscow official or chancery language, during the 15th to 17th centuries. Since then, the trend of language policy in Russia has been standardization in both the restricted sense of reducing dialectical barriers between ethnic Russians, and

13432-477: The greatest diamonds of the world, known ever since as the Orlov Diamond . By the time he returned — without permission — to his Marble Palace at Saint Petersburg, Orlov found himself superseded in the empress's favor by the younger Grigory Potemkin . When Potemkin, in 1774, superseded Vasilchikov as the queen's lover, Orlov became of no account at court and went abroad for some years. He returned to Russia

13578-429: The group was able to recreate viable virus in a short time frame with relatively little cost or effort. Although the WHO bans individual laboratories from synthesizing more than 20% of the genome at a time, and purchases of smallpox genome fragments are monitored and regulated, a group with malicious intentions could compile, from multiple sources, the full synthetic genome necessary to produce viable virus. Smallpox

13724-498: The hosts' immune systems, and are primarily responsible for the variability in virulence across the orthopoxvirus family. These terminal regions in poxviruses are inverted terminal repetitions (ITR) sequences. These sequences are identical but oppositely oriented on either end of the genome, leading to the genome being a continuous loop of DNA. Components of the ITR sequences include an incompletely base paired A/T rich hairpin loop ,

13870-436: The lesions remained almost flush with the skin at the time when raised vesicles would have formed in the ordinary type. It is unknown why some people developed this type. Historically, it accounted for 5–10% of cases, and most (72%) were children. Malignant smallpox was accompanied by a severe prodromal phase that lasted 3–4 days, prolonged high fever, and severe symptoms of viremia . The prodromal symptoms continued even after

14016-406: The lower respiratory tract] are maintained”. Once inhaled, the variola virus invaded the mucous membranes of the mouth, throat, and respiratory tract. From there, it migrated to regional lymph nodes and began to multiply. In the initial growth phase, the virus seemed to move from cell to cell, but by around the 12th day, widespread lysis of infected cells occurred and the virus could be found in

14162-408: The malignant and hemorrhagic forms were usually fatal. The modified form was almost never fatal. In early hemorrhagic cases, hemorrhages occurred before any skin lesions developed. The incubation period between contraction and the first obvious symptoms of the disease was 7–14 days. At least 90% of smallpox cases among unvaccinated persons were of the ordinary type. In this form of the disease, by

14308-472: The northwestern Xinjiang Uyghur Autonomous Region . Russian was also the main foreign language taught in school in China between 1949 and 1964. In Kazakhstan , Russian is not a state language, but according to article 7 of the Constitution of Kazakhstan its usage enjoys equal status to that of the Kazakh language in state and local administration. The 2009 census reported that 10,309,500 people, or 84.8% of

14454-404: The onset of the rash. The rash on the mucous membranes ( enanthem ) was extensive. Skin lesions matured slowly, were typically confluent or semi-confluent, and by the seventh or eighth day, they were flat and appeared to be buried in the skin. Unlike ordinary-type smallpox, the vesicles contained little fluid, were soft and velvety to the touch, and may have contained hemorrhages. Malignant smallpox

14600-429: The oral, nasal, or pharyngeal mucosa of an infected person. It was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person. Some infections of laundry workers with smallpox after handling contaminated bedding suggested that smallpox could be spread through direct contact with contaminated objects ( fomites ), but this was found to be rare. Also rarely, smallpox

14746-464: The other being rinderpest (a disease of even-toed ungulates ) in 2011. The term "smallpox" was first used in England in the 16th century to distinguish the disease from syphilis , which was then known as the "great pox". Other historical names for the disease include pox, speckled monster, and red plague. The United States and Russia retain samples of variola virus in laboratories, which has sparked debates over safety . There are two forms of

14892-515: The other hand, before the war, almost a quarter of Ukrainians were in favour of granting Russian the status of the state language, while after the beginning of Russia's invasion the support for the idea dropped to just 7%. In peacetime, the idea of raising the status of Russian was traditionally supported by residents of the south and east . But even in these regions, only a third of the respondents were in favour, and after Russia's full-scale invasion , their number dropped by almost half. According to

15038-461: The other three languages in the East Slavic branch. In many places in eastern and southern Ukraine and throughout Belarus, these languages are spoken interchangeably, and in certain areas traditional bilingualism resulted in language mixtures such as Surzhyk in eastern Ukraine and Trasianka in Belarus. An East Slavic Old Novgorod dialect , although it vanished during the 15th or 16th century,

15184-523: The outer layers of skin from the underlying flesh. Patients with confluent smallpox often remained ill even after scabs had formed over all the lesions. In one case series, the case-fatality rate in confluent smallpox was 62%. Referring to the character of the eruption and the rapidity of its development, modified smallpox occurred mostly in previously vaccinated people. It was rare in unvaccinated people, with one case study showing 1–2% of modified cases compared to around 25% in vaccinated people. In this form,

15330-446: The parliament approved a bill to close up all Russian language schools and kindergartens by the school year. The transition to only Estonian language schools and kindergartens will start in the 2024-2025 school year. In Latvia , Russian is officially considered a foreign language. 55% of the population was fluent in Russian in 2006, and 26% used it as the main language with family, friends, or at work. On 18 February 2012, Latvia held

15476-453: The peasants' speech was never systematically studied, as it was generally regarded by philologists as simply a source of folklore and an object of curiosity. This was acknowledged by the noted Russian dialectologist Nikolai Karinsky , who toward the end of his life wrote: "Scholars of Russian dialects mostly studied phonetics and morphology. Some scholars and collectors compiled local dictionaries. We have almost no studies of lexical material or

15622-588: The person was infected with variola virus, a severe infection could result, and the person could transmit smallpox to others. Variolation had a 0.5–2 percent mortality rate, considerably less than the 20–30 percent mortality rate of smallpox. Two reports on the Chinese practice of inoculation were received by the Royal Society in London in 1700; one by Dr. Martin Lister who received a report by an employee of

15768-459: The plague epidemic, which caused a " Plague Riot " in the city, stopped looting, opened hospitals and orphanages. Meanwhile, Orlov's enemies, led by Panin, were attempting to break up the relationship between Orlov and Catherine. They informed the empress that Orlov had seduced his 13-year-old relative. A handsome young officer, Alexander Vasilchikov , was installed as her new lover. To rekindle Catherine's affection, Grigory presented to her one of

15914-459: The population aged 15 and above, could read and write well in Russian, and understand the spoken language. In October 2023, Kazakhstan drafted a media law aimed at increasing the use of the Kazakh language over Russian, the law stipulates that the share of the state language on television and radio should increase from 50% to 70%, at a rate of 5% per year, starting in 2025. In Kyrgyzstan , Russian

16060-418: The population was fluent in Russian in 2006, and 67% used it as the main language with family, friends, or at work. According to the 2019 Belarusian census , out of 9,413,446 inhabitants of the country, 5,094,928 (54.1% of the total population) named Belarusian as their native language, with 61.2% of ethnic Belarusians and 54.5% of ethnic Poles declaring Belarusian as their native language. In everyday life in

16206-497: The practice arrived in Europe. The idea that inoculation originated in India has been challenged, as few of the ancient Sanskrit medical texts described the process of inoculation. Accounts of inoculation against smallpox in China can be found as early as the late 10th century, and the procedure was widely practiced by the 16th century, during the Ming dynasty . If successful, inoculation produced lasting immunity to smallpox. Because

16352-491: The prodromal illness still occurred but may have been less severe than in the ordinary type. There was usually no fever during the evolution of the rash. The skin lesions tended to be fewer and evolved more quickly, were more superficial, and may not have shown the uniform characteristic of more typical smallpox. Modified smallpox was rarely, if ever, fatal. This form of variola major was more easily confused with chickenpox . In malignant-type smallpox (also called flat smallpox)

16498-479: The pronunciation of ultra-short or reduced /ŭ/ , /ĭ/ . Because of many technical restrictions in computing and also because of the unavailability of Cyrillic keyboards abroad, Russian is often transliterated using the Latin alphabet. For example, мороз ('frost') is transliterated moroz , and мышь ('mouse'), mysh or myš' . Once commonly used by the majority of those living outside Russia, transliteration

16644-472: The proper pronunciation of uncommon words or names. Russian is an East Slavic language of the wider Indo-European family . It is a descendant of Old East Slavic , a language used in Kievan Rus' , which was a loose conglomerate of East Slavic tribes from the late 9th to the mid-13th centuries. From the point of view of spoken language , its closest relatives are Ukrainian , Belarusian , and Rusyn ,

16790-491: The respondents), while according to the 2002 census – 142.6 million people (99.2% of the respondents). In Ukraine , Russian is a significant minority language. According to estimates from Demoskop Weekly, in 2004 there were 14,400,000 native speakers of Russian in the country, and 29 million active speakers. 65% of the population was fluent in Russian in 2006, and 38% used it as the main language with family, friends, or at work. On 5 September 2017, Ukraine's Parliament passed

16936-454: The same size since the viral effect progresses more uniformly. A variety of laboratory methods were available for detecting chickenpox in the evaluation of suspected smallpox cases. The earliest procedure used to prevent smallpox was inoculation with variola minor virus (a method later known as variolation after the introduction of smallpox vaccine to avoid possible confusion), which likely occurred in India, Africa, and China well before

17082-479: The second day of the rash the macules had become raised papules . By the third or fourth day, the papules had filled with an opalescent fluid to become vesicles . This fluid became opaque and turbid within 24–48 hours, resulting in pustules . By the sixth or seventh day, all the skin lesions had become pustules. Between seven and ten days the pustules had matured and reached their maximum size. The pustules were sharply raised, typically round, tense, and firm to

17228-491: The separation of variola virus from Taterapox (an Orthopoxvirus of some African rodents including gerbils ) at 3,000 to 4,000 years ago. This is consistent with archaeological and historical evidence regarding the appearance of smallpox as a human disease which suggests a relatively recent origin. If the mutation rate is assumed to be similar to that of the herpesviruses , the divergence date of variola virus from Taterapox has been estimated to be 50,000 years ago. While this

17374-427: The smallpox. Variola major is the severe and most common form, with a more extensive rash and higher fever. Variola minor is a less common presentation, causing less severe disease, typically discrete smallpox, with historical death rates of 1% or less. Subclinical ( asymptomatic ) infections with variola virus were noted but were not common. In addition, a form called variola sine eruptione (smallpox without rash)

17520-520: The spleen, kidney, serous membranes , skeletal muscles, pericardium , liver, gonads and bladder. Historically, this condition was frequently misdiagnosed, with the correct diagnosis made only at autopsy. This form is more likely to occur in pregnant women than in the general population (approximately 16% of cases in unvaccinated pregnant women were early hemorrhagic smallpox, versus roughly 1% in nonpregnant women and adult males). The case fatality rate of early hemorrhagic smallpox approaches 100%. There

17666-456: The summer of 1761, he caught the fancy of the then Grand Duchess Catherine Alekseyevna , became her favourite (until 1772), and was the leader of the conspiracy which resulted in the dethronement and death of her husband, Emperor Peter III (1762). After the event, Empress Catherine raised him to the rank of count and made him adjutant-general , director-general of engineers, and general-in-chief. They had an illegitimate son, Aleksey who

17812-679: The survey carried out by RATING in August 2023 in the territory controlled by Ukraine and among the refugees, almost 60% of the polled usually speak Ukrainian at home, about 30% – Ukrainian and Russian, only 9% – Russian. Since March 2022, the use of Russian in everyday life has been noticeably decreasing. For 82% of respondents, Ukrainian is their mother tongue, and for 16%, Russian is their mother tongue. IDPs and refugees living abroad are more likely to use both languages for communication or speak Russian. Nevertheless, more than 70% of IDPs and refugees consider Ukrainian to be their native language. In

17958-459: The syntax of Russian dialects." After 1917, Marxist linguists had no interest in the multiplicity of peasant dialects and regarded their language as a relic of the rapidly disappearing past that was not worthy of scholarly attention. Nakhimovsky quotes the Soviet academicians A.M Ivanov and L.P Yakubinsky, writing in 1930: The language of peasants has a motley diversity inherited from feudalism. On its way to becoming proletariat peasantry brings to

18104-425: The temperature fell to near-normal. These lesions rapidly enlarged and ruptured, releasing large amounts of virus into the saliva. Variola virus tended to attack skin cells, causing the characteristic pimples, or macules , associated with the disease. A rash developed on the skin 24 to 48 hours after lesions on the mucous membranes appeared. Typically the macules first appeared on the forehead, then rapidly spread to

18250-411: The touch. The pustules were deeply embedded in the dermis, giving them the feel of a small bead in the skin. Fluid slowly leaked from the pustules, and by the end of the second week, the pustules had deflated and began to dry up, forming crusts or scabs. By day 16–20 scabs had formed over all of the lesions, which had started to flake off, leaving depigmented scars. Ordinary smallpox generally produced

18396-786: The two. Others divide the language into three groupings, Northern , Central (or Middle), and Southern , with Moscow lying in the Central region. The Northern Russian dialects and those spoken along the Volga River typically pronounce unstressed /o/ clearly, a phenomenon called okanye ( оканье ). Besides the absence of vowel reduction, some dialects have high or diphthongal /e⁓i̯ɛ/ in place of Proto-Slavic  * ě and /o⁓u̯ɔ/ in stressed closed syllables (as in Ukrainian) instead of Standard Russian /e/ and /o/ , respectively. Another Northern dialectal morphological feature

18542-511: The use of the language has some presence in certain areas. A large part of the population, especially the older generations, can speak Russian as a foreign language. However, English has replaced Russian as lingua franca in Lithuania and around 80% of young people speak English as their first foreign language. In contrast to the other two Baltic states, Lithuania has a relatively small Russian-speaking minority (5.0% as of 2008). According to

18688-475: The vesicular stage. Hemorrhages in the mucous membranes appear to occur less often than in the early hemorrhagic form. Sometimes the rash forms pustules which bleed at the base and then undergo the same process as in ordinary smallpox. This form of the disease is characterized by a decrease in all of the elements of the coagulation cascade and an increase in circulating antithrombin . This form of smallpox occurs anywhere from 3% to 25% of fatal cases, depending on

18834-439: The virulence of the smallpox strain. Most people with the late-stage form die within eight to 10 days of illness. Among the few who recover, the hemorrhagic lesions gradually disappear after a long period of convalescence. The case fatality rate for late hemorrhagic smallpox is around 90–95%. Pregnant women are slightly more likely to experience this form of the disease, though not as much as early hemorrhagic smallpox. Smallpox

18980-442: The virus on chorioallantoic membrane (part of a chicken embryo ) and examining the resulting pock lesions under defined temperature conditions. Strains were characterized by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. Serologic tests and enzyme linked immunosorbent assays (ELISA), which measured variola virus-specific immunoglobulin and antigen were also developed to assist in

19126-554: The whole face, proximal portions of extremities, the trunk, and lastly to distal portions of extremities. The process took no more than 24 to 36 hours, after which no new lesions appeared. At this point, variola major disease could take several very different courses, which resulted in four types of smallpox disease based on the Rao classification: ordinary, modified, malignant (or flat), and hemorrhagic smallpox. Historically, ordinary smallpox had an overall fatality rate of about 30%, and

19272-621: Was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind. The earliest evidence of the disease dates to around 1500 BC in Egyptian mummies . The disease historically occurred in outbreaks . It was one of several diseases introduced by the Columbian exchange to the New World , resulting in large swathes of Native Americans dying . In 18th-century Europe, it

19418-431: Was also called white pox, kaffir pox, Cuban itch, West Indian pox, milk pox, and pseudovariola. The genome of variola major virus is about 186,000 base pairs in length. It is made from linear double stranded DNA and contains the coding sequence for about 200 genes . The genes are usually not overlapping and typically occur in blocks that point towards the closer terminal region of the genome. The coding sequence of

19564-405: Was first introduced in North America when Russian explorers voyaged into Alaska and claimed it for Russia during the 18th century. Although most Russian colonists left after the United States bought the land in 1867, a handful stayed and preserved the Russian language in this region to this day, although only a few elderly speakers of this unique dialect are left. In Nikolaevsk, Alaska , Russian

19710-421: Was fluent in Russian in 2006, and 19% used it as the main language with family, friends, or at work. According to the 2014 Moldovan census , Russians accounted for 4.1% of Moldova's population, 9.4% of the population declared Russian as their native language, and 14.5% said they usually spoke Russian. According to the 2010 census in Russia , Russian language skills were indicated by 138 million people (99.4% of

19856-428: Was highly contagious, but generally spread more slowly and less widely than some other viral diseases, perhaps because transmission required close contact and occurred after the onset of the rash. The overall rate of infection was also affected by the short duration of the infectious stage. In temperate areas, the number of smallpox infections was highest during the winter and spring. In tropical areas, seasonal variation

20002-442: Was less evident and the disease was present throughout the year. Age distribution of smallpox infections depended on acquired immunity . Vaccination immunity declined over time and was probably lost within thirty years. Smallpox was not known to be transmitted by insects or animals and there was no asymptomatic carrier state. Transmission occurred through inhalation of airborne variola virus, usually droplets expressed from

20148-576: Was named after the village of Bobriki , and from whom descends the line of the Count Bobrinsky . Orlov's influence became paramount after the discovery of the Khitrovo plot (led by Fyodor Alekseevich Khitrovo) to murder the whole Orlov family. At one time, the Empress thought of marrying her favorite, but the plan was frustrated by her influential advisor Nikita Panin . Orlov had a quick wit,

20294-421: Was nearly always fatal and death usually occurred between the 8th and 12th day of illness. Often, a day or two before death, the lesions turned ashen gray, which, along with abdominal distension, was a bad prognostic sign. This form is thought to be caused by deficient cell-mediated immunity to smallpox. If the person recovered, the lesions gradually faded and did not form scars or scabs. Hemorrhagic smallpox

20440-573: Was one of the earliest propagandists of the Slavophile idea of the emancipation of the Christians from Ottoman rule. In 1771, he was sent as first Russian plenipotentiary to the peace congress of Focşani , but he failed in his mission, owing partly to the obstinacy of the Ottomans, and partly (according to Panin) to his own outrageous insolence. In 1771 in Moscow he stopped the spread of

20586-456: Was seen generally in vaccinated persons. This form was marked by a fever that occurred after the usual incubation period and could be confirmed only by antibody studies or, rarely, by viral culture . In addition, there were two very rare and fulminating types of smallpox, the malignant (flat) and hemorrhagic forms, which were usually fatal. The initial symptoms were similar to other viral diseases that are still extant, such as influenza and

20732-440: Was spread by virus carried in the air in enclosed settings such as buildings, buses, and trains. The virus can cross the placenta , but the incidence of congenital smallpox was relatively low. Smallpox was not notably infectious in the prodromal period and viral shedding was usually delayed until the appearance of the rash, which was often accompanied by lesions in the mouth and pharynx. The virus can be transmitted throughout

20878-404: Was the primary cause of smallpox outbreaks across Asia and most of Africa. Meanwhile, variola minor was more commonly found in regions of Europe, North America, South America, and certain parts of Africa. Variola minor virus, also called alastrim, was a less common form of the virus, and much less deadly. Although variola minor had the same incubation period and pathogenetic stages as smallpox, it

21024-402: Was the sixth-most used language on the top 1,000 sites, behind English, Chinese, French, German, and Japanese. Despite leveling after 1900, especially in matters of vocabulary and phonetics, a number of dialects still exist in Russia. Some linguists divide the dialects of Russian into two primary regional groupings, "Northern" and "Southern", with Moscow lying on the zone of transition between

21170-516: Was the variola major strains (the more clinically severe form of smallpox) which spread from Asia between 400 and 1,600 years ago. A second clade included both alastrim (a phenotypically mild smallpox) described from the American continents and isolates from West Africa which diverged from an ancestral strain between 1,400 and 6,300 years before present. This clade further diverged into two subclades at least 800 years ago. A second estimate has placed

21316-420: Was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects . Prevention was achieved mainly through the smallpox vaccine . Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after the disease was eradicated. The risk of death

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