Kodak Hall at Eastman Theatre is the largest performance venue at the Eastman School of Music of the University of Rochester , located in downtown Rochester, New York , United States.
106-479: The theatre was established by industrialist George Eastman and opened on September 4, 1922, as a center for music, dance, and silent film, with orchestral and organ accompaniment. The theatre is the primary hall for the Eastman School's larger ensembles, including its orchestras, wind ensembles, jazz ensembles, and chorale. It originally contained 3,352 seats, but was substantially revised in 2009 to become
212-673: A 2,260-seat concert hall with state-of-the-art acoustics optimized for symphonic, popular and chamber music performances. The theatre is the principal performance venue for the Rochester Philharmonic Orchestra , and the Eastman Opera Theatre presents fully staged operatic productions each spring. A $ 5 million renovation of the theater building was completed in October 2004. Eastman Kodak Company, founded by George Eastman, donated $ 10 million for
318-541: A dental care clinic for children opened in 1937 in Stockholm , Sweden. Marion Gleason, a close confidante of Eastman, later described his views on African Americans as "typical of his time – paternalistic, but strictly against social fraternization." Although he made generous donations to the Hampton Institute and Tuskegee Institute , becoming their largest donor in his era, he also upheld and reinforced
424-528: A direct appeal from president Walter White in 1929. From 1925 until his death, Eastman donated $ 10,000 per year to the American Eugenics Society (increasing the donation to $ 15,000 in 1932), a popular cause among many of the upper class when there were concerns about immigration and "race mixing". In his final two years, Eastman was in intense pain due to a disorder affecting his spine . He had trouble standing, and his walk became
530-537: A few significantly enlarged motor neurons doing work previously performed by as many as four or five units: a single motor neuron that once controlled 200 muscle cells might control 800 to 1000 cells. Other mechanisms that occur during the rehabilitation phase, and contribute to muscle strength restoration, include myofiber hypertrophy – enlargement of muscle fibers through exercise and activity – and transformation of type II muscle fibers to type I muscle fibers . In addition to these physiological processes,
636-742: A live, attenuated virus. It was produced by the repeated passage of the virus through nonhuman cells at sub physiological temperatures. The attenuated poliovirus in the Sabin vaccine replicates very efficiently in the gut, the primary site of wild poliovirus infection and replication, but the vaccine strain is unable to replicate efficiently within nervous system tissue. A single dose of Sabin's trivalent OPV produces immunity to all three poliovirus serotypes in about 50 percent of recipients. Three doses of OPV produce protective antibody to all three poliovirus types in more than 95 percent of recipients. Human trials of Sabin's vaccine began in 1957, and in 1958, it
742-450: A local inflammatory response . In most cases, this causes a self-limiting inflammation of the meninges , the layers of tissue surrounding the brain , which is known as nonparalytic aseptic meningitis. Penetration of the CNS provides no known benefit to the virus, and is quite possibly an incidental deviation of a normal gastrointestinal infection. The mechanisms by which poliovirus spreads to
848-478: A major illness involving the CNS, which may be paralytic or nonparalytic. Adults are more likely to develop symptoms, including severe symptoms, than children. In most people with a normal immune system , a poliovirus infection is asymptomatic . In about 25% of cases, the infection produces minor symptoms which may include sore throat and low fever. These symptoms are temporary and full recovery occurs within one or two weeks. In about 1 percent of infections
954-719: A major role in planning and financing the campaign for a new global calendar, and also headed the National Committee on Calendar Simplification, in the United States, which was created at the behest of the League of Nations . Eastman supported Cotsworth's campaign until his death. Eastman wrote several articles to promote the 13-month system, including "Problems of Calendar Improvement" in Scientific American and "The Importance of Calendar Reform to
1060-589: A member of the genus Enterovirus known as poliovirus (PV). This group of RNA viruses colonize the gastrointestinal tract – specifically the oropharynx and the intestine . Its structure is quite simple, composed of a single (+) sense RNA genome enclosed in a protein shell called a capsid . In addition to protecting the virus' genetic material, the capsid proteins enable poliovirus to infect certain types of cells. Three serotypes of poliovirus have been identified – wild poliovirus type 1 (WPV1), type 2 (WPV2), and type 3 (WPV3) – each with
1166-667: A note which read, "To my friends: my work is done. Why wait?" Eastman is regarded as one of the most influential and well-known residents of Rochester, New York . He has been commemorated on several college campuses and the Hollywood Walk of Fame , and the George Eastman Museum has been designated a National Historic Landmark . Eastman was born in Waterville, New York , as the youngest child of George Washington Eastman and Maria Eastman (née Kilbourn), at
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#17327765205011272-444: A nutritious diet. Treatment of polio often requires long-term rehabilitation, including occupational therapy , physical therapy , braces, corrective shoes and, in some cases, orthopedic surgery . Portable ventilators may be required to support breathing. Historically, a noninvasive, negative-pressure ventilator, more commonly called an iron lung , was used to artificially maintain respiration during an acute polio infection until
1378-541: A passion for playing the piano. The loss of his mother, Maria, was particularly crushing to George. Almost pathologically concerned with decorum, he found himself, for the first time, unable to control his emotions in the presence of his friends. "When my mother died I cried all day", he said later. "I could not have stopped to save my life." Due to his mother's reluctance to accept his gifts, Eastman could never do enough for his mother during her lifetime. He continued to honor her after her death. On September 4, 1922, he opened
1484-456: A permanent residual impairment after recovery from the acute illness, and both overuse and disuse of neurons. PPS is a slow, progressive disease, and there is no specific treatment for it. Post-polio syndrome is not an infectious process, and persons experiencing the syndrome do not shed poliovirus. Paralysis, length differences and deformations of the lower extremities can lead to a hindrance when walking with compensation mechanisms that lead to
1590-553: A person could breathe independently (generally about one to two weeks). The use of iron lungs is largely obsolete in modern medicine as more modern breathing therapies have been developed and due to the eradication of polio in most of the world. Other historical treatments for polio include hydrotherapy , electrotherapy , massage and passive motion exercises, and surgical treatments, such as tendon lengthening and nerve grafting. Patients with abortive polio infections recover completely. In those who develop only aseptic meningitis,
1696-450: A profit-sharing program for all employees in 1912. Eastman never married. He was close to his mother and to his sister Ellen Maria and her family. He had a long platonic relationship with Josephine Dickman, a trained singer and the wife of business associate George Dickman. He became especially close to Dickman after the death of his mother, Maria Eastman, in 1907. He was also an avid traveler, enjoyed music and social gatherings, and had
1802-457: A severe impairment of the gait pattern. In order to be able to stand and walk safely and to improve the gait pattern, orthotics can be included in the therapy concept. Today, modern materials and functional elements enable the orthosis to be specifically adapted to the requirements resulting from the patient's gait. Mechanical stance phase control knee joints may secure the knee joint in the early stance phases and release again for knee flexion when
1908-424: A slightly different capsid protein. All three are extremely virulent and produce the same disease symptoms. WPV1 is the most commonly encountered form, and the one most closely associated with paralysis. WPV2 was certified as eradicated in 2015 and WPV3 certified as eradicated in 2019. The incubation period (from exposure to the first signs and symptoms) ranges from three to six days for nonparalytic polio. If
2014-401: A slow shuffle. Today, it might be diagnosed as a form of degenerative disease such as disc herniations from trauma or age causing either painful nerve root compressions, or perhaps a type of lumbar spinal stenosis , a narrowing of the spinal canal caused by calcification in the vertebrae . Since his mother suffered the final two years of her life in a wheelchair, she also may have had
2120-460: A spine condition but that is uncertain. Only her uterine cancer and successful surgery are documented in her health history. As a result of his pain, Eastman suffered from depression . On March 14, 1932, Eastman died by suicide with a single gunshot through the heart. His suicide note read, "To my friends, my work is done – Why wait? GE." Raymond Granger, an insurance salesman in Rochester,
2226-636: A subsequent renovation that was completed in October 2009; the building's concert hall was named "Kodak Hall at Eastman Theatre", in recognition of the donation. Maxfield Parrish 's painting "Interlude" originally hung in the Eastman Theatre. The original was moved to the Memorial Art Gallery in 1997 to stabilize its temperature and humidity, and a full-size color reproduction hung in its place. George Eastman George Eastman (July 12, 1854 – March 14, 1932)
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#17327765205012332-462: A type of monkey kidney tissue culture ( vero cell line ), which is chemically inactivated with formalin . After two doses of IPV (given by injection ), 90 percent or more of individuals develop protective antibody to all three serotypes of poliovirus, and at least 99 percent are immune to poliovirus following three doses. Subsequently, Albert Sabin developed a polio vaccine that can be administered orally (oral polio vaccine - OPV), comprising
2438-455: Is called respiratory or bulbospinal polio. Here, the virus affects the upper part of the cervical spinal cord ( cervical vertebrae C3 through C5), and paralysis of the diaphragm occurs. The critical nerves affected are the phrenic nerve (which drives the diaphragm to inflate the lungs ) and those that drive the muscles needed for swallowing. By destroying these nerves, this form of polio affects breathing, making it difficult or impossible for
2544-648: Is displayed at the Genesee Country Village and Museum . Polio Poliomyelitis ( / ˌ p oʊ l i oʊ ˌ m aɪ ə ˈ l aɪ t ɪ s / POH -lee-oh- MY -ə- LY -tiss ), commonly shortened to polio , is an infectious disease caused by the poliovirus . Approximately 75% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache , neck stiffness, and paresthesia . These symptoms usually pass within one or two weeks. A less common symptom
2650-416: Is known as acute flaccid paralysis . The weakness most often involves the legs, but may less commonly involve the muscles of the head, neck, and diaphragm . Depending on the site of paralysis, paralytic poliomyelitis is classified as spinal, bulbar , or bulbospinal. In those who develop paralysis, between 2 and 10 percent die as the paralysis affects the breathing muscles. Encephalitis , an infection of
2756-413: Is less effective at preventing spread of wild poliovirus by the fecal–oral route. Because the oral polio vaccine is inexpensive, easy to administer, and produces excellent immunity in the intestine (which helps prevent infection with wild virus in areas where it is endemic ), it has been the vaccine of choice for controlling poliomyelitis in many countries. On very rare occasions, the attenuated virus in
2862-416: Is most infectious between 7 and 10 days before and after the appearance of symptoms, but transmission is possible as long as the virus remains in the saliva or feces. Virus particles can be excreted in the feces for up to six weeks. Factors that increase the risk of polio infection include pregnancy , the very old and the very young, immune deficiency , and malnutrition . Although the virus can cross
2968-526: Is no specific treatment. The disease can be prevented by the polio vaccine , with multiple doses required for lifelong protection. There are two broad types of polio vaccine; an injected polio vaccine (IPV) using inactivated poliovirus and an oral polio vaccine (OPV) containing attenuated (weakened) live virus. Through the use of both types of vaccine, incidence of wild polio has decreased from an estimated 350,000 cases in 1988 to 30 confirmed cases in 2022, confined to just three countries. In rare cases,
3074-459: Is permanent paralysis , and possible death in extreme cases. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to what the person had during the initial infection. Polio occurs naturally only in humans. It is highly infectious, and is spread from person to person either through fecal–oral transmission (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via
3180-420: Is possible up to 18 months after infection. One mechanism involved in recovery is nerve terminal sprouting, in which remaining brainstem and spinal cord motor neurons develop new branches, or axonal sprouts. These sprouts can reinnervate orphaned muscle fibers that have been denervated by acute polio infection, restoring the fibers' capacity to contract and improving strength. Terminal sprouting may generate
3286-430: Is that one leg is shorter than the other and the person limps and leans to one side, in turn leading to deformities of the spine (such as scoliosis ). Osteoporosis and increased likelihood of bone fractures may occur. An intervention to prevent or lessen length disparity can be to perform an epiphysiodesis on the distal femoral and proximal tibial/fibular condyles, so that limb's growth is artificially stunted, and by
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3392-443: Is usually complete by the time the fever breaks. The likelihood of developing paralytic polio increases with age, as does the extent of paralysis. In children, nonparalytic meningitis is the most likely consequence of CNS involvement, and paralysis occurs in only one in 1000 cases. In adults, paralysis occurs in one in 75 cases. In children under five years of age, paralysis of one leg is most common; in adults, extensive paralysis of
3498-463: Is usually made based on the recovery of poliovirus from a stool sample or a swab of the pharynx . Rarely, it may be possible to identify poliovirus in the blood or in the cerebrospinal fluid . Poliovirus samples are further analysed using reverse transcription polymerase chain reaction (RT-PCR) or genomic sequencing to determine the serotype (i.e., 1, 2, or 3), and whether the virus is a wild or vaccine-derived strain. In 1950, William Hammon at
3604-580: The Charles River , and Tuskegee University and Hampton University , two historically black universities in the South . With interests in improving health, he provided funds for clinics in London and other European cities to serve low-income residents. In his final two years, Eastman was in intense pain caused by a disorder affecting his spine. On March 14, 1932, he shot himself in the heart, leaving
3710-605: The Eastman Theatre in Rochester, which included a chamber-music hall, Kilbourn Theater, dedicated to his mother's memory. At the Eastman House he maintained a rose bush, using a cutting from her childhood home. Eastman was a presidential elector in 1900 and 1916 . In 1915, Eastman founded the Bureau of Municipal Research in Rochester to gather information and make government policy recommendations. The agency
3816-580: The Motion Picture Patents Company in 1908, Eastman negotiated for Kodak to be sole supplier of film to the industry. His monopolistic actions attracted the attention of the federal government, which began an anti-trust investigation into Kodak in 1911 for exclusive contracts, acquisitions of competitors, and price-fixing. This resulted in a lawsuit against Kodak in 1913 and a final judgement in 1921, ordering Kodak to stop fixing prices and sell many of its interests. Kodak's growth
3922-464: The University of Pittsburgh purified the gamma globulin component of the blood plasma of polio survivors. Hammon proposed the gamma globulin, which contained antibodies to poliovirus, could be used to halt poliovirus infection, prevent disease, and reduce the severity of disease in other patients who had contracted polio. The results of a large clinical trial were promising; the gamma globulin
4028-422: The chest and abdomen also affecting all four limbs – quadriplegia – is more likely. Paralysis rates also vary depending on the serotype of the infecting poliovirus; the highest rates of paralysis (one in 200) are associated with poliovirus type 1, the lowest rates (one in 2,000) are associated with type 2. Spinal polio, the most common form of paralytic poliomyelitis, results from viral invasion of
4134-421: The cranial nerves , producing symptoms of encephalitis , and causes difficulty breathing , speaking and swallowing. Critical nerves affected are the glossopharyngeal nerve (which partially controls swallowing and functions in the throat, tongue movement, and taste), the vagus nerve (which sends signals to the heart, intestines, and lungs), and the accessory nerve (which controls upper neck movement). Due to
4240-411: The maternal-fetal barrier during pregnancy, the fetus does not appear to be affected by either maternal infection or polio vaccination. Maternal antibodies also cross the placenta , providing passive immunity that protects the infant from polio infection during the first few months of life. Poliovirus enters the body through the mouth, infecting the first cells with which it comes in contact –
4346-422: The pharynx and intestinal mucosa . It gains entry by binding to an immunoglobulin-like receptor, known as the poliovirus receptor or CD155 , on the cell membrane. The virus then hijacks the host cell's own machinery, and begins to replicate . Poliovirus divides within gastrointestinal cells for about a week, from where it spreads to the tonsils (specifically the follicular dendritic cells residing within
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4452-632: The 10-acre (4.0 ha) farm which his parents had bought in 1849. He had two older sisters, Ellen Maria and Katie. He was largely self-educated, although he attended a private school in Rochester after the age of eight. In the early 1840s his father had started a business school, the Eastman Commercial College in Rochester, New York . The city became one of the first "boomtowns" in the United States, based on its rapid industrialization. As his father's health started deteriorating,
4558-421: The 1920s, Eastman was involved in calendar reform and supported the 13-month per year International Fixed Calendar developed by Moses B. Cotsworth . On January 17, 1925, Eastman invited Cotsworth to his home; he had been introduced to Cotsworth's calendar by a mutual friend and was interested in the system. He secretly funded Cotsworth for a year and then openly supported him and the 13-month plan. Eastman took
4664-714: The American Ambassador to the UK. The clinic was incorporated into the Royal Free Hospital and was committed to providing dental care for disadvantaged children from central London. It is now a part of University College London . In 1929 he founded the George Eastman Visiting Professorship at Oxford , to be held each year by a different American scholar of the highest distinction. Eastman also funded Eastmaninstitutet ,
4770-757: The Business World" in Nation's Business . By 1928, the Kodak Company implemented the calendar in its business bookkeeping, and continued to use it until 1989. He was chairman of the National Committee on Calendar Simplification. Although a conference was held at the League of Nations in 1931, with his death and the looming tensions of World War II , this calendar was dropped from consideration. In 1925 Eastman gave up his daily management of Kodak and officially retired as president. He remained associated with
4876-399: The CNS are poorly understood, but it appears to be primarily a chance event – largely independent of the age, gender, or socioeconomic position of the individual. In around one percent of infections, poliovirus spreads along certain nerve fiber pathways, preferentially replicating in and destroying motor neurons within the spinal cord , brain stem , or motor cortex . This leads to
4982-631: The River Campus of the University of Rochester is named for Eastman. The Rochester Institute of Technology has a building dedicated to him, in recognition of his support and substantial donations. MIT installed a plaque of Eastman on one of the buildings he funded. (Students rub the nose of Eastman's image on the plaque for good luck.) Eastman had built a mansion at 900 East Avenue in Rochester. Here he entertained friends to dinner and held private music concerts. The University of Rochester used
5088-562: The Sabin OPV can revert into a form that can paralyze. In 2017, cases caused by vaccine-derived poliovirus (cVDPV) outnumbered wild poliovirus cases for the first time, due to wild polio cases hitting record lows. Most industrialized countries have switched to inactivated polio vaccine, which cannot revert, either as the sole vaccine against poliomyelitis or in combination with oral polio vaccine. An improved oral vaccine (Novel oral polio vaccine type 2 - nOPV2) began development in 2011 and
5194-404: The acute infection, notably new muscle weakness and extreme fatigue. This condition is known as post-polio syndrome (PPS) or post-polio sequelae. The symptoms of PPS are thought to involve a failure of the oversized motor units created during the recovery phase of the paralytic disease. Contributing factors that increase the risk of PPS include aging with loss of neuron units, the presence of
5300-511: The alias "Mr. Smith". In 1918, he endowed the establishment of the Eastman School of Music at the University of Rochester, and in 1921 a school of medicine and dentistry there. In 1922, he founded the Rochester Philharmonic Orchestra , hiring its first music director Albert Coates . Figured for its value in 1932, the year of Eastman's death, $ 100 million is equivalent to more than $ 2 billion in 2022. In 1915, Eastman provided funds for
5406-430: The blood and lymphatics for long periods of time, sometimes as long as 17 weeks. In a small percentage of cases, it can spread and replicate in other sites, such as brown fat , the reticuloendothelial tissues, and muscle. This sustained replication causes a major viremia, and leads to the development of minor influenza-like symptoms. Rarely, this may progress and the virus may invade the central nervous system, provoking
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#17327765205015512-446: The body can compensate for residual paralysis in other ways. Weaker muscles can be used at a higher than usual intensity relative to the muscle's maximal capacity , little-used muscles can be developed, and ligaments can enable stability and mobility. Residual complications of paralytic polio often occur following the initial recovery process. Muscle paresis and paralysis can sometimes result in skeletal deformities, tightening of
5618-474: The brain tissue itself, can occur in rare cases, and is usually restricted to infants. It is characterized by confusion, changes in mental status, headaches, fever, and, less commonly, seizures and spastic paralysis . The term poliomyelitis derives from the Ancient Greek poliós ( πολιός ), meaning "grey", myelós ( µυελός "marrow"), referring to the grey matter of the spinal cord , and
5724-709: The camera was immediately popular with the public. By August 1888, Eastman was struggling to meet orders, and he and his employees soon had several other cameras in development. The rapidly-growing Eastman Dry Plate Company was reorganized as the Eastman Company In 1889, and then incorporated as Eastman Kodak in 1892. Eastman recognized that most of his revenue would come from the sale of additional film rolls, rather than camera sales, and focused on film production. By providing quality and affordable film to every camera manufacturer, Kodak managed to turn competitors into de facto business partners. In 1889 he patented
5830-693: The color and appearance of the gray matter in the spinal column , causing it to appear reddish and swollen. Other destructive changes associated with paralytic disease occur in the forebrain region, specifically the hypothalamus and thalamus . Early symptoms of paralytic polio include high fever, headache, stiffness in the back and neck, asymmetrical weakness of various muscles, sensitivity to touch, difficulty swallowing , muscle pain , loss of superficial and deep reflexes , paresthesia (pins and needles), irritability, constipation, or difficulty urinating. Paralysis generally develops one to ten days after early symptoms begin, progresses for two to three days, and
5936-437: The company experienced rapid growth. By 1896, Kodak was the leading supplier of film stock internationally, and by 1915, the company was the largest employer in Rochester, with over 8,000 employees and annual earnings of $ 15.7 Million. In 1934, shortly after Eastman's death, Kodak employed 23,000. One of the largest markets for film became the emerging motion picture industry . When Thomas Edison and other film producers formed
6042-544: The company in a business executive capacity, as the chairman of the board, until his death. During his lifetime, Eastman donated $ 100 million to various organizations, becoming one of the major philanthropists in the United States during his lifetime. His largest donations went to the University of Rochester and to the Massachusetts Institute of Technology to build their programs and facilities. Preferring to remain anonymous, he made donations under
6148-627: The de facto segregation which existed in Rochester. Kodak hired virtually no black employees during Eastman's lifetime, and a 1939 commission of the New York State Legislature on living conditions of African Americans found that Kodak had only a single black employee. The Eastman Dental Dispensary also rejected black applicants, and the Eastman Theater restricted black patrons to its balcony. Eastman rejected several requests to meet with NAACP representatives, including
6254-491: The development of paralytic poliomyelitis, the various forms of which (spinal, bulbar, and bulbospinal) vary only with the amount of neuronal damage and inflammation that occurs, and the region of the CNS affected. The destruction of neuronal cells produces lesions within the spinal ganglia ; these may also occur in the reticular formation , vestibular nuclei , cerebellar vermis , and deep cerebellar nuclei . Inflammation associated with nerve cell destruction often alters
6360-415: The disease progresses to cause paralysis, this occurs within 7 to 21 days. Individuals who are exposed to the virus, either through infection or by immunization via polio vaccine , develop immunity . In immune individuals, IgA antibodies against poliovirus are present in the tonsils and gastrointestinal tract and able to block virus replication ; IgG and IgM antibodies against PV can prevent
6466-622: The effect on swallowing, secretions of mucus may build up in the airway, causing suffocation. Other signs and symptoms include facial weakness (caused by destruction of the trigeminal nerve and facial nerve , which innervate the cheeks, tear ducts , gums, and muscles of the face, among other structures), double vision , difficulty in chewing, and abnormal respiratory rate , depth, and rhythm (which may lead to respiratory arrest ). Pulmonary edema and shock are also possible and may be fatal. Approximately 19 percent of all paralytic polio cases have both bulbar and spinal symptoms; this subtype
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#17327765205016572-814: The establishment of the Eastman Dental Dispensary in Rochester. He donated £200,000 in 1926 to fund a dental clinic in London after being approached by the chairman of the Royal Free Hospital , George Riddell, 1st Baron Riddell . Donations of £50,000 each had been made by Lord Riddell and the Royal Free honorary treasurer. On November 20, 1931, the UCL Eastman Dental Institute opened in a ceremony attended by Neville Chamberlain , then Minister of Health, and
6678-483: The family gave up the farm and moved to Rochester in 1860. His father died of a brain disorder on April 27, 1862. To survive and afford George's schooling, his mother took in boarders. The second daughter, Katie, had contracted polio when young and died in late 1870 when George was 15 years old. The young George left school early and started working to help support the family. As Eastman began to have success with his photography business, he vowed to repay his mother for
6784-531: The film industry. Eastman was a major philanthropist, establishing the Eastman School of Music , Rochester Philharmonic Orchestra , and schools of dentistry and medicine at the University of Rochester and Eastman Dental Hospital at University College London , and making large contributions to the Rochester Institute of Technology (RIT), the construction of several buildings at the second campus of Massachusetts Institute of Technology (MIT) on
6890-425: The first marketed integral tripack film. During World War I , Eastman established a photographic school in Rochester to train pilots for aerial reconnaissance . In an era of growing trade union activities, Eastman sought to counter the union movement by anticipating worker demands. To this end, he implemented a number of worker benefit programs, including a welfare fund to provide workmen's compensation in 1910 and
6996-531: The hardships she had endured in raising him. While working as a bank clerk in the 1870s, Eastman became interested in photography. After receiving lessons from George Monroe and George Selden , he developed a machine for coating dry plates in 1879. In 1881, he founded the Eastman Dry Plate Company with Henry Strong to sell plates, with Strong as company president and Eastman as treasurer, where he handled most executive functions. Around
7102-400: The joints, and movement disability. Once the muscles in the limb become flaccid, they may interfere with the function of other muscles. A typical manifestation of this problem is equinus foot (similar to club foot ). This deformity develops when the muscles that pull the toes downward are working, but those that pull it upward are not, and the foot naturally tends to drop toward the ground. If
7208-464: The legs, due to pooling of blood in paralyzed lower limbs. Complications from prolonged immobility involving the lungs , kidneys and heart include pulmonary edema , aspiration pneumonia , urinary tract infections , kidney stones , paralytic ileus , myocarditis and cor pulmonale . Between 25 percent and 50 percent of individuals who have recovered from paralytic polio in childhood can develop additional symptoms decades after recovering from
7314-409: The limb joins the body) than distally (the fingertips and toes ). Making up about two percent of cases of paralytic polio, bulbar polio occurs when poliovirus invades and destroys nerves within the bulbar region of the brain stem . The bulbar region is a white matter pathway that connects the cerebral cortex to the brain stem. The destruction of these nerves weakens the muscles supplied by
7420-503: The mansion for various purposes for decades after his death. In 1949, it re-opened after having been adapted for use as the George Eastman House International Museum of Photography and Film. It has been designated a National Historic Landmark , and is now known as the George Eastman Museum . Eastman's boyhood home was saved from destruction. It was restored to its state during his childhood and
7526-482: The motor neurons of the anterior horn cells , or the ventral (front) grey matter section in the spinal column , which are responsible for movement of the muscles, including those of the trunk , limbs , and the intercostal muscles . Virus invasion causes inflammation of the nerve cells, leading to damage or destruction of motor neuron ganglia . When spinal neurons die, Wallerian degeneration takes place, leading to weakness of those muscles formerly innervated by
7632-417: The natural or "wild" poliovirus (WPV). Poliomyelitis is highly contagious. The disease is transmitted primarily via the fecal–oral route , by ingesting contaminated food or water. It is occasionally transmitted via the oral–oral route. It is seasonal in temperate climates , with peak transmission occurring in summer and autumn. These seasonal differences are far less pronounced in tropical areas. Polio
7738-478: The now-dead neurons. With the destruction of nerve cells, the muscles no longer receive signals from the brain or spinal cord; without nerve stimulation, the muscles atrophy , becoming weak, floppy and poorly controlled, and finally completely paralyzed. Maximum paralysis progresses rapidly (two to four days), and usually involves fever and muscle pain. Deep tendon reflexes are also affected, and are typically absent or diminished; sensation (the ability to feel) in
7844-510: The oral–oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood. Poliomyelitis has existed for thousands of years, with depictions of the disease in ancient art. The disease was first recognized as a distinct condition by the English physician Michael Underwood in 1789, and
7950-550: The paralysis of muscles used for breathing. The case fatality rate (CFR) varies by age: 2 to 5 percent of children and up to 15 to 30 percent of adults die. Bulbar polio often causes death if respiratory support is not provided; with support, its CFR ranges from 25 to 75 percent, depending on the age of the patient. When intermittent positive pressure ventilation is available, the fatalities can be reduced to 15 percent. Many cases of poliomyelitis result in only temporary paralysis. Generally in these cases, nerve impulses return to
8056-436: The paralyzed limbs, however, is not affected. The extent of spinal paralysis depends on the region of the cord affected, which may be cervical , thoracic , or lumbar . The virus may affect muscles on both sides of the body, but more often the paralysis is asymmetrical . Any limb or combination of limbs may be affected – one leg, one arm, or both legs and both arms. Paralysis is often more severe proximally (where
8162-407: The paralyzed muscle within a month, and recovery is complete in six to eight months. The neurophysiological processes involved in recovery following acute paralytic poliomyelitis are quite effective; muscles are able to retain normal strength even if half the original motor neurons have been lost. Paralysis remaining after one year is likely to be permanent, although some recovery of muscle strength
8268-479: The patient to breathe without the support of a ventilator . It can lead to paralysis of the arms and legs and may also affect swallowing and heart functions. Paralytic poliomyelitis may be clinically suspected in individuals experiencing acute onset of flaccid paralysis in one or more limbs with decreased or absent tendon reflexes in the affected limbs that cannot be attributed to another apparent cause, and without sensory or cognitive loss. A laboratory diagnosis
8374-476: The photographer mailed the camera back to the Eastman company in Rochester, along with $ 10. The company would process the film, make a print of each exposure, load another roll of film into the camera, and send the camera and the prints to the photographer. The separation of photo-taking from the difficult process of film development was novel and made photography more accessible to amateurs than ever before, and
8480-491: The problem is left untreated, the Achilles tendons at the back of the foot retract and the foot cannot take on a normal position. People with polio that develop equinus foot cannot walk properly because they cannot put their heels on the ground. A similar situation can develop if the arms become paralyzed. In some cases the growth of an affected leg is slowed by polio, while the other leg continues to grow normally. The result
8586-440: The processes for the first nitrocellulose film along with chemist Henry Reichenbach. A number of patent infringement lawsuits would preoccupy Eastman and his lawyers in subsequent years, including one from Reichenbach after he was fired in 1892. The largest lawsuit would come from rival film producer Ansco . Inventor Hannibal Goodwin had filed a patent for nitrocellulose film in 1887, prior to Eastman and Reichenbach's, but it
8692-490: The remaining quarter are left with severe disability. The degree of both acute paralysis and residual paralysis is likely to be proportional to the degree of viremia , and inversely proportional to the degree of immunity . Spinal polio is rarely fatal. Without respiratory support, consequences of poliomyelitis with respiratory involvement include suffocation or pneumonia from aspiration of secretions . Overall, 5 to 10 percent of patients with paralytic polio die due to
8798-451: The same time, he began experiments to create a flexible film roll that could replace plates altogether. In 1885, he received a patent for a film roll, and then focused on creating a camera to use the rolls. In 1888, he patented and released the Kodak camera ("Kodak" being a word Eastman created). It was sold loaded with enough roll film for 100 exposures. When all the exposures had been made,
8904-548: The spread of the virus to motor neurons of the central nervous system . Infection or vaccination with one serotype of poliovirus does not provide immunity against the other serotypes, and full immunity requires exposure to each serotype. A rare condition with a similar presentation, nonpoliovirus poliomyelitis, may result from infections with enteroviruses other than poliovirus. The oral polio vaccine, which has been in use since 1961, contains weakened viruses that can replicate. On rare occasions, these may be transmitted from
9010-522: The suffix -itis , which denotes inflammation , i.e., inflammation of the spinal cord's grey matter. The word was first used in 1874 and is attributed to the German physician Adolf Kussmaul . The first recorded use of the abbreviated version polio was in the Indianapolis Star in 1911. Poliomyelitis does not affect any species other than humans. The disease is caused by infection with
9116-426: The swing phase is initiated. With the help of an orthotic treatment with a stance phase control knee joint, a natural gait pattern can be achieved despite mechanical protection against unwanted knee flexion. In these cases, locked knee joints are often used, which have a good safety function, but do not allow knee flexion when walking during swing phase. With such joints, the knee joint remains mechanically blocked during
9222-430: The swing phase. Patients with locked knee joints must swing the leg forward with the knee extended even during the swing phase. This only works if the patient develops compensatory mechanisms, e.g. by raising the body's center of gravity in the swing phase (Duchenne limping) or by swinging the orthotic leg to the side (circumduction). Major polio epidemics were unknown before the 20th century; up until that time, polio
9328-410: The symptoms can be expected to persist for two to ten days, followed by complete recovery. In cases of spinal polio, if the affected nerve cells are completely destroyed, paralysis will be permanent; cells that are not destroyed, but lose function temporarily, may recover within four to six weeks after onset. Half the patients with spinal polio recover fully; one-quarter recover with mild disability, and
9434-411: The time of epiphyseal (growth) plate closure, the legs are more equal in length. Alternatively, a person can be fitted with custom-made footwear which corrects the difference in leg lengths. Other surgery to re-balance muscular agonist/antagonist imbalances may also be helpful. Extended use of braces or wheelchairs may cause compression neuropathy , as well as a loss of proper function of the veins in
9540-421: The tonsilar germinal centers ), the intestinal lymphoid tissue including the M cells of Peyer's patches , and the deep cervical and mesenteric lymph nodes , where it multiplies abundantly. The virus is subsequently absorbed into the bloodstream. Known as viremia , the presence of a virus in the bloodstream enables it to be widely distributed throughout the body. Poliovirus can survive and multiply within
9646-524: The traditional OPV was able to revert to a virulent form. An improved oral vaccine with greater genetic stability (nOPV2) was developed and granted full licensure in December 2023. The term "poliomyelitis" is used to identify the disease caused by any of the three serotypes of poliovirus. Two basic patterns of polio infection are described: a minor illness that does not involve the central nervous system (CNS), sometimes called abortive poliomyelitis, and
9752-431: The vaccinated person to other people; in communities with good vaccine coverage , transmission is limited, and the virus dies out. In communities with low vaccine coverage, this weakened virus may continue to circulate and, over time may mutate and revert to a virulent form. Polio arising from this cause is referred to as circulating vaccine-derived poliovirus (cVDPV) or variant poliovirus in order to distinguish it from
9858-485: The virus can migrate from the gastrointestinal tract into the central nervous system (CNS). Most patients with CNS involvement develop nonparalytic aseptic meningitis , with symptoms of headache, neck, back, abdominal and extremity pain, fever, vomiting, stomach pain, lethargy , and irritability. About one to five in 1,000 cases progress to paralytic disease, in which the muscles become weak, floppy and poorly controlled, and, finally, completely paralyzed; this condition
9964-674: The virus that causes it was first identified in 1909 by the Austrian immunologist Karl Landsteiner . Major outbreaks started to occur in the late 19th century in Europe and the United States , and in the 20th century, it became one of the most worrying childhood diseases . Following the introduction of polio vaccines in the 1950s, polio incidence declined rapidly. As of October 2023 , only Pakistan and Afghanistan remain endemic for wild poliovirus (WPV). Once infected, there
10070-417: The world to combat polio: an inactivated poliovirus given by injection, and a weakened poliovirus given by mouth. Both types induce immunity to polio and are effective in protecting individuals from disease. The inactivated polio vaccine (IPV) was developed in 1952 by Jonas Salk at the University of Pittsburgh, and announced to the world on 12 April 1955. The Salk vaccine is based on poliovirus grown in
10176-484: Was an American entrepreneur who founded the Eastman Kodak Company and helped to bring the photographic use of roll film into the mainstream. After a decade of experiments in photography, he patented and sold a roll film camera, making amateur photography accessible to the general public for the first time. Working as the treasurer and later president of Kodak, he oversaw the expansion of the company and
10282-413: Was an endemic disease worldwide. Mothers who had survived polio infection passed on temporary immunity to their babies in the womb and through breast milk. As a result, an infant who encountered a polio infection generally suffered only mild symptoms and acquired a long-term immunity to the disease. With improvements in sanitation and hygiene during the 19th century, the general level of herd immunity in
10388-509: Was buried in the grounds of the company he founded, at what is now known as Eastman Business Park . The Security Trust Company of Rochester was the executor of Eastman's estate. His entire estate was bequeathed to the University of Rochester. Eastman disdained public notoriety and sought to tightly control his image. He was reluctant to share information in interviews, and on multiple occasions both Eastman and Kodak blocked biographers from full access to his records. A definitive biography
10494-475: Was finally published in 1996. Eastman is the only person represented by two stars in the Film category in the Hollywood Walk of Fame , one on the north side of the 6800 block of Hollywood Boulevard and the other one on the west side of the 1700 block of Vine Street . Both recognize the same achievement, that he developed bromide paper , which became a standard of the film industry. The Eastman Quadrangle of
10600-518: Was granted emergency licencing in 2021, and subsequently full licensure in December 2023. This has greater genetic stability than the traditional oral vaccine and is less likely to revert to a virulent form. There is no cure for polio, but there are treatments. The focus of modern treatment has been on providing relief of symptoms, speeding recovery and preventing complications. Supportive measures include antibiotics to prevent infections in weakened muscles, analgesics for pain, moderate exercise and
10706-529: Was later renamed the Center for Governmental Research and continues to carry out that mission. In 1924, Eastman and the Bureau supported a referendum to change Rochester's government to a city manager system, which passed. In 1920, Eastman established the Eastman Savings and Loan to provide financial services to Kodak employees. The institution was later rechartered as ESL Federal Credit Union . In
10812-434: Was not granted until 1898. Ansco purchased the patent in 1900 and sued Kodak for infringement. Kodak ultimately lost the suit, which lasted over a decade and cost the company $ 5 Million. Eastman paid close attention to Kodak's advertisements. He coined the slogan, “ You press the button, we do the rest ”, which became ubiquitous in the general public. As Kodak pursued a monopoly on film through patents and acquisitions,
10918-650: Was selected, in competition with the live attenuated vaccines of Koprowski and other researchers, by the US National Institutes of Health. Licensed in 1962, it rapidly became the only oral polio vaccine used worldwide. OPV efficiently blocks person-to-person transmission of wild poliovirus by oral–oral and fecal–oral routes, thereby protecting both individual vaccine recipients and the wider community. The live attenuated virus may be transmitted from vaccinees to their unvaccinated contacts, resulting in wider community immunity. IPV confers good immunity but
11024-413: Was shown to be about 80 percent effective in preventing the development of paralytic poliomyelitis. It was also shown to reduce the severity of the disease in patients who developed polio. Due to the limited supply of blood plasma gamma globulin was later deemed impractical for widespread use and the medical community focused on the development of a polio vaccine. Two types of vaccine are used throughout
11130-485: Was sustained during the 20th century by new innovations in film and cameras, including the Brownie camera, which was marketed to children. Eastman took interest in color photography in 1904, and funded experiments in color film production for the next decade. The resulting product, created by John Capstaff, was a two-color process named Kodachrome. Later, in 1935, Kodak would release the more famous second Kodachrome ,
11236-433: Was visiting to collect insurance payments from several members of the staff. He arrived at the scene to find the workforce shocked and upset. At least one chronicler said that Eastman's fear of senility or other debilitating diseases of old age was a contributing factor to his action. Eastman's funeral was held at St. Paul's Episcopal Church in Rochester; his coffin was carried out to Charles Gounod 's "Marche Romaine". It
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