162-573: Francis Harry Compton Crick OM FRS (8 June 1916 – 28 July 2004) was an English molecular biologist , biophysicist , and neuroscientist . He, James Watson , Rosalind Franklin , and Maurice Wilkins played crucial roles in deciphering the helical structure of the DNA molecule . Crick and Watson's paper in Nature in 1953 laid the groundwork for understanding DNA structure and functions. Together with Maurice Wilkins, they were jointly awarded
324-659: A Neutrality Pact in April 1941, and Japan adopted the doctrine of Nanshin-ron , promoted by the Navy, which took its focus southward and eventually led to war with the United States and the Western Allies. In Europe, Germany and Italy were becoming more aggressive. In March 1938, Germany annexed Austria , again provoking little response from other European powers. Encouraged, Hitler began pressing German claims on
486-578: A cautious French probe into the Saarland . The Western Allies also began a naval blockade of Germany , which aimed to damage the country's economy and war effort. Germany responded by ordering U-boat warfare against Allied merchant and warships, which would later escalate into the Battle of the Atlantic . On 8 September, German troops reached the suburbs of Warsaw . The Polish counter-offensive to
648-638: A PhD at UCL, but was interrupted by World War II . He later became a PhD student and Honorary Fellow of Gonville and Caius College, Cambridge , and mainly worked at the Cavendish Laboratory and the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge. He was also an Honorary Fellow of Churchill College, Cambridge , and of University College, London. Crick began a PhD research project on measuring
810-451: A good molecular model of its structure. A key piece of experimentally-derived information came from X-ray diffraction images that had been obtained by Wilkins, Franklin, and Gosling. In November 1951, Wilkins came to Cambridge and shared his data with Watson and Crick. Alexander Stokes (another expert in helical diffraction theory) and Wilkins (both at King's College) had reached the conclusion that X-ray diffraction data for DNA indicated that
972-455: A helical structure was not the only possible shape for DNA—so they had a dilemma. In an effort to clarify this issue, Max Ferdinand Perutz later published what had been in the progress report, and suggested that nothing was in the report that Franklin herself had not said in her talk (attended by Watson) in late 1951. Perutz explained that the report was to a Medical Research Council (MRC) committee that had been created to "establish contact between
1134-557: A longer article on 12 June 1953). The university's undergraduate newspaper Varsity also ran its own short article on the discovery on Saturday 30 May 1953. Bragg's original announcement of the discovery at a Solvay conference on proteins in Belgium on 8 April 1953 went unreported by the British press. In a seven-page, handwritten letter to his son at a British boarding school on 19 March 1953 Crick explained his discovery, beginning
1296-465: A means to acknowledge "exceptionally meritorious service in Our Navy and Our Army, or who may have rendered exceptionally meritorious service towards the advancement of Art, Literature and Science". All modern aspects of the order were established under his direction, including the division for military figures. From the outset, prime ministers attempted to propose candidates or lobbied to influence
1458-740: A neck ribbon (as a necklet ), while women wear theirs on a ribbon bow pinned to the left shoulder, and aides-de-camp may wear the insignia on their aiguillettes . Since 1991, the insignia must be returned upon the recipient's death. number appointment There have been no honorary members of the Order of Merit since the death of the last such member, Nelson Mandela , in December 2013. Secretary and Registrar : Robin Janvrin, Baron Janvrin GCB , GCVO , QSO , PC As
1620-524: A pretext to initiate the invasion. The first German attack of the war came against the Polish defences at Westerplatte . The United Kingdom responded with an ultimatum for Germany to cease military operations, and on 3 September, after the ultimatum was ignored, Britain and France declared war on Germany. During the Phoney War period, the alliance provided no direct military support to Poland, outside of
1782-726: A pretext to worsen relations. On 29 August, Hitler demanded that a Polish plenipotentiary immediately travel to Berlin to negotiate the handover of Danzig , and to allow a plebiscite in the Polish Corridor in which the German minority would vote on secession. The Poles refused to comply with the German demands, and on the night of 30–31 August in a confrontational meeting with the British ambassador Nevile Henderson , Ribbentrop declared that Germany considered its claims rejected. On 1 September 1939, Germany invaded Poland after having staged several false flag border incidents as
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#17327830082471944-553: A scientific search for answers over religious belief. Walter Crick, his uncle, lived in a small house on the south side of Abington Avenue; he had a shed at the bottom of his little garden where he taught Crick to blow glass, do chemical experiments and to make photographic prints. When he was eight or nine he transferred to the most junior form of the Northampton Grammar School , on the Billing Road. This
2106-461: A second attempt to do so. They asked for, and received, permission to do so from both William Lawrence Bragg and Wilkins. To construct their model of DNA, Watson and Crick made use of information from unpublished X-ray diffraction images of Franklin's (shown at meetings and freely shared by Wilkins), including preliminary accounts of Franklin's results/photographs of the X-ray images that were included in
2268-475: A secret protocol that defined German and Soviet "spheres of influence" (western Poland and Lithuania for Germany; eastern Poland , Finland, Estonia , Latvia and Bessarabia for the Soviet Union), and raised the question of continuing Polish independence. The pact neutralised the possibility of Soviet opposition to a campaign against Poland and assured that Germany would not have to face the prospect of
2430-774: A similar pact and rejected ceding part of its territory to the Soviet Union. The Soviet Union invaded Finland in November 1939, and was subsequently expelled from the League of Nations for this crime of aggression. Despite overwhelming numerical superiority, Soviet military success during the Winter War was modest, and the Finno-Soviet war ended in March 1940 with some Finnish concessions of territory . In June 1940,
2592-466: A small audience in Moscow at a 1961 conference. Crick's reaction was to invite Nirenberg to deliver his talk to a larger audience. Watson and Crick's use of DNA X-ray diffraction data collected by Franklin and Wilkins has generated an enduring controversy. It arose from the fact that some of Franklin's unpublished data were used without her knowledge or consent by Watson and Crick in their construction of
2754-542: A synthetic DNA. In addition to synthetic DNA there are also attempts to construct synthetic codons , synthetic endonucleases , synthetic proteins and synthetic zinc fingers . Using synthetic DNA, instead of there being 4 codons, if there are n new bases there could be as many as n codons. Research is currently being done to see if codons can be expanded to more than 3 bases. These new codons can code for new amino acids. These synthetic molecules can be used not only in medicine, but in creation of new materials. The discovery
2916-531: A two-front war, as it had in World War I. Immediately afterwards, Hitler ordered the attack to proceed on 26 August, but upon hearing that the United Kingdom had concluded a formal mutual assistance pact with Poland and that Italy would maintain neutrality, he decided to delay it. In response to British requests for direct negotiations to avoid war, Germany made demands on Poland, which served as
3078-417: A while they were forbidden to make further efforts to find a molecular model of DNA. Of great importance to the model building effort of Watson and Crick was Rosalind Franklin's understanding of basic chemistry, which indicated that the hydrophilic phosphate -containing backbones of the nucleotide chains of DNA should be positioned so as to interact with water molecules on the outside of the molecule while
3240-535: A written progress report for the King's College laboratory of Sir John Randall from late 1952. It is a matter of debate whether Watson and Crick should have had access to Franklin's results without her knowledge or permission, and before she had a chance to formally publish the results of her detailed analysis of her X-ray diffraction data which were included in the progress report. However, Watson and Crick found fault in her steadfast assertion that, according to her data,
3402-526: Is relevant both to peptide bonds in proteins and the structure of nucleotides in DNA. In 1951 and 1952, together with William Cochran and Vladimir Vand, Crick assisted in the development of a mathematical theory of X-ray diffraction by a helical molecule. This theoretical result matched well with X-ray data for proteins that contain sequences of amino acids in the alpha helix conformation. Helical diffraction theory turned out to also be useful for understanding
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#17327830082473564-399: Is what made Crick confident that DNA was a double helix with antiparallel chains, but there were other chains of reasoning and sources of information that also led to these conclusions. As a result of leaving King's College for Birkbeck College , Franklin was asked by John Randall to give up her work on DNA. When it became clear to Wilkins and the supervisors of Watson and Crick that Franklin
3726-604: The Anglo-German Naval Agreement and the German–Polish declaration of non-aggression . The situation became a crisis in late August as German troops continued to mobilise against the Polish border. On 23 August the Soviet Union signed a non-aggression pact with Germany, after tripartite negotiations for a military alliance between France, the United Kingdom, and Soviet Union had stalled. This pact had
3888-573: The Battle of Trafalgar in 1805, First Lord of the Admiralty Charles Middleton, 1st Baron Barham and William Pitt exchanged correspondence concerning the possible creation of an order of merit, though nothing came of the idea. Later, Queen Victoria , her courtiers , and politicians alike, thought that a new order, based on the Prussian order Pour le Mérite , would make up for the insufficient recognition offered by
4050-689: The British Empire , with fighting in the Balkans , Mediterranean, and Middle East , the aerial Battle of Britain and the Blitz , and naval Battle of the Atlantic . Through a series of campaigns and treaties, Germany took control of much of continental Europe and formed the Axis alliance with Italy , Japan , and other countries. In June 1941, Germany led the European Axis in an invasion of
4212-581: The German Revolution of 1918–1919 , and a democratic government, later known as the Weimar Republic , was created. The interwar period saw strife between supporters of the new republic and hardline opponents on both the political right and left. Italy, as an Entente ally, had made some post-war territorial gains; however, Italian nationalists were angered that the promises made by the United Kingdom and France to secure Italian entrance into
4374-853: The German invasion of Poland and the United Kingdom and France 's declaration of war on Germany two days later on 3 September 1939. Dates for the beginning of the Pacific War include the start of the Second Sino-Japanese War on 7 July 1937, or the earlier Japanese invasion of Manchuria , on 19 September 1931. Others follow the British historian A. J. P. Taylor , who stated that the Sino-Japanese War and war in Europe and its colonies occurred simultaneously, and
4536-576: The Italian mainland , and Allied offensives in the Pacific—cost the Axis powers their initiative and forced them into strategic retreat on all fronts. In 1944, the Western Allies invaded German-occupied France at Normandy , while the Soviet Union regained its territorial losses and pushed Germany and its allies westward. At the same time, Japan suffered reversals in mainland Asia, while the Allies crippled
4698-553: The Japanese Navy and captured key islands . The war in Europe concluded with the liberation of German-occupied territories ; the invasion of Germany by the Western Allies and the Soviet Union, culminating in the fall of Berlin to Soviet troops; Hitler's suicide ; and the German unconditional surrender on 8 May 1945 . Following the refusal of Japan to surrender on the terms of the Potsdam Declaration ,
4860-695: The League of Nations as a force to preserve peace. Both Italy and Ethiopia were member nations, but the League did little when the former clearly violated Article X of the League's Covenant . The United Kingdom and France supported imposing sanctions on Italy for the invasion, but the sanctions were not fully enforced and failed to end the Italian invasion. Italy subsequently dropped its objections to Germany's goal of absorbing Austria . When civil war broke out in Spain, Hitler and Mussolini lent military support to
5022-538: The Lieutenant Governor of Nova Scotia , stated that the Order of Merit was the highest civilian award for merit a Canadian could receive. Some orders of precedence are as follows: Order of wear World War II Asia-Pacific Mediterranean and Middle East Other campaigns Coups World War II or the Second World War (1 September 1939 – 2 September 1945)
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5184-731: The Nationalist rebels , led by General Francisco Franco . Italy supported the Nationalists to a greater extent than the Nazis: Mussolini sent more than 70,000 ground troops, 6,000 aviation personnel, and 720 aircraft to Spain. The Soviet Union supported the existing government of the Spanish Republic . More than 30,000 foreign volunteers, known as the International Brigades , also fought against
5346-557: The Nobel Prize in Physiology or Medicine in 1962 with Wilkins. When Watson came to Cambridge, Crick was a 35-year-old graduate student (due to his work during WWII) and Watson was only 23, but had already obtained a PhD. They shared an interest in the fundamental problem of learning how genetic information might be stored in molecular form. Watson and Crick talked endlessly about DNA and the idea that it might be possible to guess
5508-690: The Rome–Berlin Axis . A month later, Germany and Japan signed the Anti-Comintern Pact , which Italy joined the following year. The Kuomintang (KMT) party in China launched a unification campaign against regional warlords and nominally unified China in the mid-1920s, but was soon embroiled in a civil war against its former Chinese Communist Party (CCP) allies and new regional warlords . In 1931, an increasingly militaristic Empire of Japan , which had long sought influence in China as
5670-588: The Royal Air Force and, in 1969, the definition of honorary recipients was expanded to include members of the Commonwealth of Nations that are not realms. The order has always been open to women, Florence Nightingale being the first woman to receive the honour, in 1907. Several individuals have refused admission into the Order of Merit, including Rudyard Kipling , A. E. Housman , and George Bernard Shaw . Prince Philip, Duke of Edinburgh , remains
5832-590: The Soviet–Japanese Neutrality Pact in April 1941. By contrast, the Germans were steadily making preparations for an attack on the Soviet Union, massing forces on the Soviet border. Hitler believed that the United Kingdom's refusal to end the war was based on the hope that the United States and the Soviet Union would enter the war against Germany sooner or later. On 31 July 1940, Hitler decided that
5994-598: The Stresa Front in April 1935 in order to contain Germany, a key step towards military globalisation ; however, that June, the United Kingdom made an independent naval agreement with Germany, easing prior restrictions. The Soviet Union, concerned by Germany's goals of capturing vast areas of Eastern Europe , drafted a treaty of mutual assistance with France. Before taking effect, though, the Franco-Soviet pact
6156-709: The Sudetenland , an area of Czechoslovakia with a predominantly ethnic German population. Soon the United Kingdom and France followed the appeasement policy of British Prime Minister Neville Chamberlain and conceded this territory to Germany in the Munich Agreement , which was made against the wishes of the Czechoslovak government, in exchange for a promise of no further territorial demands. Soon afterwards, Germany and Italy forced Czechoslovakia to cede additional territory to Hungary, and Poland annexed
6318-707: The Tanggu Truce was signed in 1933. Thereafter, Chinese volunteer forces continued the resistance to Japanese aggression in Manchuria , and Chahar and Suiyuan . After the 1936 Xi'an Incident , the Kuomintang and CCP forces agreed on a ceasefire to present a united front to oppose Japan. The Second Italo-Ethiopian War was a brief colonial war that began in October 1935 and ended in May 1936. The war began with
6480-579: The Trans-Olza region of Czechoslovakia. Although all of Germany's stated demands had been satisfied by the agreement, privately Hitler was furious that British interference had prevented him from seizing all of Czechoslovakia in one operation. In subsequent speeches Hitler attacked British and Jewish "war-mongers" and in January 1939 secretly ordered a major build-up of the German navy to challenge British naval supremacy. In March 1939, Germany invaded
6642-558: The Treaty of Craiova . The loss of one-third of Romania's 1939 territory caused a coup against King Carol II, turning Romania into a fascist dictatorship under Marshal Ion Antonescu , with a course set towards the Axis in the hopes of a German guarantee. Meanwhile, German-Soviet political relations and economic co-operation gradually stalled, and both states began preparations for war. In April 1940, Germany invaded Denmark and Norway to protect shipments of iron ore from Sweden , which
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6804-749: The United Kingdom and France to declare war on Germany. Poland was divided between Germany and the Soviet Union under the Molotov–Ribbentrop Pact , in which they had agreed on " spheres of influence " in Eastern Europe. In 1940, the Soviets annexed the Baltic states and parts of Finland and Romania . After the fall of France in June 1940, the war continued mainly between Germany and
6966-426: The Wehrmacht rapidly advanced to the Channel and cut off the Allied forces in Belgium, trapping the bulk of the Allied armies in a cauldron on the Franco-Belgian border near Lille. The United Kingdom was able to evacuate a significant number of Allied troops from the continent by early June, although they had to abandon almost all their equipment. On 10 June, Italy invaded France , declaring war on both France and
7128-451: The aftermath of World War I and the rise of fascism in Europe and militarism in Japan . Key events leading up to the war included Japan's invasion of Manchuria , the Spanish Civil War , the outbreak of the Second Sino-Japanese War , and Germany's annexations of Austria and the Sudetenland . World War II is generally considered to have begun on 1 September 1939, when Nazi Germany , under Adolf Hitler , invaded Poland , prompting
7290-414: The hydrophobic bases should be packed into the core. Franklin shared this chemical knowledge with Watson and Crick when she pointed out to them that their first model (from 1951, with the phosphates inside) was obviously wrong. Crick described what he saw as the failure of Wilkins and Franklin to cooperate and work towards finding a molecular model of DNA as a major reason why he and Watson eventually made
7452-404: The reunification of East and West Germany to take place and resolved most post–World War II issues. No formal peace treaty between Japan and the Soviet Union was ever signed, although the state of war between the two countries was terminated by the Soviet–Japanese Joint Declaration of 1956 , which also restored full diplomatic relations between them. World War I had radically altered
7614-605: The strategic bombing of population centres and delivery of the only two nuclear weapons ever used in war. World War II was the deadliest conflict in history, resulting in 70 to 85 million deaths , more than half being civilians. Millions died in genocides , including the Holocaust of European Jews, as well as from massacres, starvation, and disease. Following the Allied powers' victory, Germany , Austria , Japan , and Korea were occupied, and war crimes tribunals were conducted against German and Japanese leaders . The causes of World War II included unresolved tensions in
7776-403: The viscosity of water at high temperatures (which he later described as "the dullest problem imaginable") in the laboratory of physicist Edward Neville da Costa Andrade at University College London, but with the outbreak of World War II (in particular, an incident during the Battle of Britain when a bomb fell through the roof of the laboratory and destroyed his experimental apparatus), Crick
7938-446: The "Order of Minerva " with membership restricted to 24 distinguished artists and authors. Knights would be entitled to the post-nominal letters KM , and would wear a silver nine-pointed breast star with the image of Minerva at its centre, along with a "straw-coloured" sash worn across the chest from the right shoulder. The motto of the Order would be "Omnia posthabita scientiae" (in Latin , 'Everything comes after science'). Once
8100-574: The "elegance and deep simplicity" of physics to the "elaborate chemical mechanisms that natural selection had evolved over billions of years." He described this transition as, "almost as if one had to be born again". According to Crick, the experience of learning physics had taught him something important—hubris—and the conviction that since physics was already a success, great advances should also be possible in other sciences such as biology. Crick felt that this attitude encouraged him to be more daring than typical biologists who tended to concern themselves with
8262-432: The 1940s, some evidence had been found pointing to another macromolecule, DNA, the other major component of chromosomes , as a candidate genetic molecule. In the 1944 Avery-MacLeod-McCarty experiment , Oswald Avery and his collaborators showed that a heritable phenotypic difference could be caused in bacteria by providing them with a particular DNA molecule. However, other evidence was interpreted as suggesting that DNA
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#17327830082478424-414: The 1962 Nobel Prize in Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material". Crick was an important theoretical molecular biologist and played a crucial role in research related to revealing the helical structure of DNA. He is widely known for the use of the term " central dogma " to summarise
8586-409: The Allies were attempting to cut off . Denmark capitulated after six hours , and despite Allied support , Norway was conquered within two months. British discontent over the Norwegian campaign led to the resignation of Prime Minister Neville Chamberlain , who was replaced by Winston Churchill on 10 May 1940. On the same day, Germany launched an offensive against France . To circumvent
8748-444: The Alpha helix, they feared that Pauling might also be the first to determine the structure of DNA. Many have speculated about what might have happened had Pauling been able to travel to Britain as planned in May 1952. As it was, his political activities caused his travel to be restricted by the United States government and he did not visit the UK until later, at which point he met none of the DNA researchers in England. At any rate he
8910-400: The Axis war against the Soviet Union, in Romania's case partially to recapture territory ceded to the Soviet Union . In early June 1940, the Italian Regia Aeronautica attacked and besieged Malta , a British possession. From late summer to early autumn, Italy conquered British Somaliland and made an incursion into British-held Egypt . In October, Italy attacked Greece , but the attack
9072-421: The Blitz , but largely ended in May 1941 after failing to significantly disrupt the British war effort. Using newly captured French ports, the German Navy enjoyed success against an over-extended Royal Navy , using U-boats against British shipping in the Atlantic . The British Home Fleet scored a significant victory on 27 May 1941 by sinking the German battleship Bismarck . In November 1939,
9234-661: The DNA double helix structure was made possible by their willingness to combine theory, modelling and experimental results (albeit mostly done by others) to achieve their goal. The DNA double helix structure proposed by Watson and Crick was based upon "Watson-Crick" bonds between the four bases most frequently found in DNA (A, C, T, G) and RNA (A, C, U, G). However, later research showed that triple-stranded, quadruple-stranded and other more complex DNA molecular structures required Hoogsteen base pairing . The entire field of synthetic biology began with work by researchers such as Erik T Kool, in which bases other than A, C, T and G are used in
9396-405: The European Axis declaring war on the US. Japan conquered much of coastal China and Southeast Asia , but its advances in the Pacific were halted in mid-1942 after its defeat in the naval Battle of Midway ; Germany and Italy were defeated in North Africa and at Stalingrad in the Soviet Union. Key setbacks in 1943—including German defeats on the Eastern Front, the Allied invasions of Sicily and
9558-410: The French possessions of Syria and Lebanon , assisted by the Free French . With the situation in Europe and Asia relatively stable, Germany, Japan, and the Soviet Union made preparations for war. With the Soviets wary of mounting tensions with Germany, and the Japanese planning to take advantage of the European War by seizing resource-rich European possessions in Southeast Asia , the two powers signed
9720-426: The Germans, and the last large operational unit of the Polish Army surrendered on 6 October . Despite the military defeat, Poland never surrendered; instead, it formed the Polish government-in-exile and a clandestine state apparatus remained in occupied Poland. A significant part of Polish military personnel evacuated to Romania and Latvia; many of them later fought against the Axis in other theatres of
9882-470: The King's proposal was made public, however, arguments within intellectual circles over who would be most deserving of the new order grew so heated that George ultimately dropped the idea, though he briefly reconsidered it in 1789; on 6 February of that year, he revised the design of the order, with the breast star to have sixteen points, the motto to be the Latin for "Learning improves character" and with membership to include distinguished scientists. Following
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#173278300824710044-450: The Nationalists. Both Germany and the Soviet Union used this proxy war as an opportunity to test in combat their most advanced weapons and tactics. The Nationalists won the civil war in April 1939; Franco, now dictator, remained officially neutral during World War II but generally favoured the Axis . His greatest collaboration with Germany was the sending of volunteers to fight on the Eastern Front . In July 1937, Japan captured
10206-426: The Order of Merit is open to the citizens of 15 countries, each with their own system of orders, decorations, and medals, the order's place of precedence varies from country to country. While, in the United Kingdom, the order's postnominal letters follow those of Knights and Dames Grand Cross of the Order of the Bath , membership in the Order of Merit itself gives members no place in any of the orders of precedence in
10368-425: The Order of Merit, members are entitled to use the post-nominal letters OM and are entrusted with the badge of the order. The insignia consists of a badge, which consists of a golden crown from which is suspended a red enamelled cross pattée , itself centred by a disk of blue enamel, surrounded by a laurel wreath . The obverse of the badge's central disk bears the words FOR MERIT in gold lettering, while
10530-452: The Royal Navy putting three Italian battleships out of commission after a carrier attack at Taranto , and neutralising several more warships at the Battle of Cape Matapan . Italian defeats prompted Germany to deploy an expeditionary force to North Africa; at the end of March 1941, Rommel 's Afrika Korps launched an offensive which drove back Commonwealth forces. In less than a month, Axis forces advanced to western Egypt and besieged
10692-423: The Soviet Union occupied the entire territories of Estonia, Latvia and Lithuania, as well as the Romanian regions of Bessarabia, Northern Bukovina, and the Hertsa region . In August 1940, Hitler imposed the Second Vienna Award on Romania which led to the transfer of Northern Transylvania to Hungary. In September 1940, Bulgaria demanded Southern Dobruja from Romania with German and Italian support, leading to
10854-421: The Soviet Union , opening the Eastern Front and initially making large territorial gains. Japan aimed to dominate East Asia and the Asia-Pacific , and by 1937 was at war with the Republic of China . In December 1941, Japan attacked American and British territories in Southeast Asia and the Central Pacific , including Pearl Harbor in Hawaii , which resulted in the US and the UK declaring war against Japan, and
11016-418: The Soviet Union and Mongolia . The Japanese doctrine of Hokushin-ron , which emphasised Japan's expansion northward, was favoured by the Imperial Army during this time. This policy would prove difficult to maintain in light of the Japanese defeat at Khalkin Gol in 1939, the ongoing Second Sino-Japanese War and ally Nazi Germany pursuing neutrality with the Soviets. Japan and the Soviet Union eventually signed
11178-575: The Soviet Union should be eliminated and aimed for the conquest of Ukraine , the Baltic states and Byelorussia . However, other senior German officials like Ribbentrop saw an opportunity to create a Euro-Asian bloc against the British Empire by inviting the Soviet Union into the Tripartite Pact. In November 1940, negotiations took place to determine if the Soviet Union would join the pact. The Soviets showed some interest but asked for concessions from Finland, Bulgaria, Turkey, and Japan that Germany considered unacceptable. On 18 December 1940, Hitler issued
11340-402: The US dropped the first atomic bombs on Hiroshima and Nagasaki on 6 and 9 August. Faced with an imminent invasion of the Japanese archipelago , the possibility of further atomic bombings, and the Soviet declaration of war against Japan and its invasion of Manchuria , Japan announced its unconditional surrender on 15 August and signed a surrender document on 2 September 1945 , marking
11502-406: The United Kingdom . However, Stanley Martin says in his book The Order of Merit 1902–2002: One Hundred Years of Matchless Honour , that the Order of Merit is the pinnacle of the British honours system. Similarly, though it was not listed in the Canadian order of precedence for honours, decorations, and medals until December 2010, Christopher McCreery, an expert on Canadian honours and secretary to
11664-581: The United Kingdom and France guaranteed their support for Polish independence ; when Italy conquered Albania in April 1939, the same guarantee was extended to the Kingdoms of Romania and Greece . Shortly after the Franco - British pledge to Poland, Germany and Italy formalised their own alliance with the Pact of Steel . Hitler accused the United Kingdom and Poland of trying to "encircle" Germany and renounced
11826-542: The United Kingdom attacked on 3 July in an attempt to prevent its seizure by Germany. The air Battle of Britain began in early July with Luftwaffe attacks on shipping and harbours . The German campaign for air superiority started in August but its failure to defeat RAF Fighter Command forced the indefinite postponement of the proposed German invasion of Britain . The German strategic bombing offensive intensified with night attacks on London and other cities in
11988-461: The United Kingdom. The Germans turned south against the weakened French army, and Paris fell to them on 14 June. Eight days later France signed an armistice with Germany ; it was divided into German and Italian occupation zones , and an unoccupied rump state under the Vichy Regime , which, though officially neutral, was generally aligned with Germany. France kept its fleet, which
12150-660: The United States was assisting China and the Western Allies, and had amended the Neutrality Act to allow "cash and carry" purchases by the Allies. In 1940, following the German capture of Paris, the size of the United States Navy was significantly increased . In September the United States further agreed to a trade of American destroyers for British bases . Still, a large majority of the American public continued to oppose any direct military intervention in
12312-593: The Walter Knox Prize for Chemistry on Mill Hill School's Foundation Day, Friday, 7 July 1933. He declared that his success was founded on the quality of teaching he received whilst a pupil at Mill Hill. Crick studied at University College London (UCL), a constituent college of the University of London and earned a Bachelor of Science degree awarded by the University of London in 1937. Crick began
12474-492: The Watson and Crick model was not the first "bases in" model to be proposed. Furberg's results had also provided the correct orientation of the DNA sugars with respect to the bases. During their model building, Crick and Watson learned that an antiparallel orientation of the two nucleotide chain backbones worked best to orient the base pairs in the centre of a double helix. Crick's access to Franklin's progress report of late 1952
12636-606: The Yellow River ; this manoeuvre bought time for the Chinese to prepare their defences at Wuhan , but the city was taken by October. Japanese military victories did not bring about the collapse of Chinese resistance that Japan had hoped to achieve; instead, the Chinese government relocated inland to Chongqing and continued the war. In the mid-to-late 1930s, Japanese forces in Manchukuo had sporadic border clashes with
12798-461: The capital Nanking in December 1937. After the fall of Nanking, tens or hundreds of thousands of Chinese civilians and disarmed combatants were murdered by the Japanese . In March 1938, Nationalist Chinese forces won their first major victory at Taierzhuang , but then the city of Xuzhou was taken by the Japanese in May. In June 1938, Chinese forces stalled the Japanese advance by flooding
12960-403: The conflict well into 1941. In December 1940, Roosevelt accused Hitler of planning world conquest and ruled out any negotiations as useless, calling for the United States to become an " arsenal of democracy " and promoting Lend-Lease programmes of military and humanitarian aid to support the British war effort; Lend-Lease was later extended to the other Allies, including the Soviet Union after it
13122-526: The creation of a " New Roman Empire ". Adolf Hitler , after an unsuccessful attempt to overthrow the German government in 1923, eventually became the Chancellor of Germany in 1933 when Paul von Hindenburg and the Reichstag appointed him. Following Hindenburg's death in 1934, Hitler proclaimed himself Führer of Germany and abolished democracy, espousing a radical, racially motivated revision of
13284-484: The data from King's College, was to guess how the nucleotide bases pack into the core of the DNA double helix. Another key to finding the correct structure of DNA was the so-called Chargaff ratios , experimentally determined ratios of the nucleotide subunits of DNA: the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine . A visit by Erwin Chargaff to England, in 1952, reinforced
13446-408: The daunting problems of biology and not the past successes of physics. For the better part of two years, Crick worked on the physical properties of cytoplasm at Cambridge's Strangeways Research Laboratory , headed by Honor Bridget Fell , with a Medical Research Council studentship, until he joined Max Perutz and John Kendrew at the Cavendish Laboratory . The Cavendish Laboratory at Cambridge
13608-464: The design of magnetic and acoustic mines and was instrumental in designing a new mine that was effective against German minesweepers . In 1947, aged 31, Crick began studying biology and became part of an important migration of physical scientists into biology research. This migration was made possible by the newly won influence of physicists such as Sir John Randall , who had helped win the war with inventions such as radar . Crick had to adjust from
13770-634: The different groups of people working for the Council". Randall's and Perutz's laboratories were both funded by the MRC. It is also not clear how important Franklin's unpublished results from the progress report actually were for the model-building done by Watson and Crick. After the first crude X-ray diffraction images of DNA were collected in the 1930s, William Astbury had talked about stacks of nucleotides spaced at 3.4 angström (0.34 nanometre) intervals in DNA. A citation to Astbury's earlier X-ray diffraction work
13932-873: The discovery of the double helix model of DNA, Crick's interests quickly turned to the biological implications of the structure. In 1953, Watson and Crick published another article in Nature which stated: "it therefore seems likely that the precise sequence of the bases is the code that carries the genetical information". In 1956, Crick and Watson speculated on the structure of small viruses. They suggested that spherical viruses such as Tomato bushy stunt virus had icosahedral symmetry and were made from 60 identical subunits. After his short time in New York, Crick returned to Cambridge where he worked until 1976, at which time he moved to California. Crick engaged in several X-ray diffraction collaborations such as one with Alexander Rich on
14094-757: The dissolution of the Austro-Hungarian, Ottoman, and Russian Empires. To prevent a future world war, the League of Nations was established in 1920 by the Paris Peace Conference . The organisation's primary goals were to prevent armed conflict through collective security, military, and naval disarmament , as well as settling international disputes through peaceful negotiations and arbitration. Despite strong pacifist sentiment after World War I , irredentist and revanchist nationalism had emerged in several European states. These sentiments were especially marked in Germany because of
14256-474: The double helix model of DNA. Of the four DNA researchers, only Franklin had a degree in chemistry; Wilkins and Crick had backgrounds in physics, Watson in biology. Member of the Order of Merit The Order of Merit (French: Ordre du Mérite ) is an order of merit for the Commonwealth realms , recognising distinguished service in the armed forces, science, art, literature, or the promotion of culture. Established in 1902 by Edward VII , admission into
14418-712: The end of May completed the German conquest of the Balkans. Partisan warfare subsequently broke out against the Axis occupation of Yugoslavia , which continued until the end of the war. In the Middle East in May, Commonwealth forces quashed an uprising in Iraq which had been supported by German aircraft from bases within Vichy-controlled Syria . Between June and July, British-led forces invaded and occupied
14580-511: The end of the war. World War II changed the political alignment and social structure of the world, and it set the foundation of international relations for the rest of the 20th century and into the 21st century. The United Nations was established to foster international cooperation and prevent conflicts, with the victorious great powers—China, France, the Soviet Union, the UK, and the US—becoming
14742-461: The established honours system to achievement outside public service, in fields such as art, music, literature, industry and science. Victoria's husband, Albert, Prince Consort , took an interest in the matter; it was recorded in his diary that he met Sir Robert Peel on 16 January 1844 to discuss the "idea of institution of a civil Order of Merit" and, three days later, he conferred with the Queen on
14904-503: The family's boot and shoe factory. His grandfather, Walter Drawbridge Crick , an amateur naturalist , wrote a survey of local foraminifera (single-celled protists with shells), corresponded with Charles Darwin , and had two gastropods (snails or slugs) named after him. At an early age, Francis was attracted to science and what he could learn about it from books. As a child, he was taken to church by his parents. But by about age 12, he said he did not want to go any more as he preferred
15066-614: The first people in April 1953 to see the model of the structure of DNA , constructed by Crick and Watson; at the time they were working at Oxford University 's Chemistry Department. All were impressed by the new DNA model, especially Brenner who subsequently worked with Crick at Cambridge in the Cavendish Laboratory and the new Laboratory of Molecular Biology . According to the late Dr. Beryl Oughton, later Rimmer, they all travelled together in two cars once Dorothy Hodgkin announced to them that they were off to Cambridge to see
15228-575: The first step of what its government saw as the country's right to rule Asia , staged the Mukden incident as a pretext to invade Manchuria and establish the puppet state of Manchukuo . China appealed to the League of Nations to stop the Japanese invasion of Manchuria. Japan withdrew from the League of Nations after being condemned for its incursion into Manchuria. The two nations then fought several battles, in Shanghai , Rehe and Hebei , until
15390-864: The former Chinese imperial capital of Peking after instigating the Marco Polo Bridge incident , which culminated in the Japanese campaign to invade all of China. The Soviets quickly signed a non-aggression pact with China to lend materiel support, effectively ending China's prior cooperation with Germany . From September to November, the Japanese attacked Taiyuan , engaged the Kuomintang Army around Xinkou , and fought Communist forces in Pingxingguan . Generalissimo Chiang Kai-shek deployed his best army to defend Shanghai , but after three months of fighting, Shanghai fell. The Japanese continued to push Chinese forces back, capturing
15552-410: The heavyweight champ." Soon after Crick's death, there have been allegations about him having used LSD when he came to the idea of the helix structure of the DNA. While he almost certainly did use LSD, it is unlikely that he did so as early as 1953. In 1954, at the age of 37, Crick completed his PhD thesis: " X-Ray Diffraction: Polypeptides and Proteins " and received his degree. Crick then worked in
15714-614: The idea that once information is transferred from nucleic acids (DNA or RNA) to proteins, it cannot flow back to nucleic acids. In other words, the final step in the flow of information from nucleic acids to proteins is irreversible. During the remainder of his career, he held the post of J.W. Kieckhefer Distinguished Research Professor at the Salk Institute for Biological Studies in La Jolla, California . His later research centred on theoretical neurobiology and attempts to advance
15876-525: The invasion of the Ethiopian Empire (also known as Abyssinia ) by the armed forces of the Kingdom of Italy ( Regno d'Italia ), which was launched from Italian Somaliland and Eritrea . The war resulted in the military occupation of Ethiopia and its annexation into the newly created colony of Italian East Africa ( Africa Orientale Italiana , or AOI); in addition it exposed the weakness of
16038-462: The key features of the protein synthesis process: The adaptor molecules were eventually shown to be tRNAs and the catalytic "ribonucleic-protein complexes" became known as ribosomes . An important step was the realisation by Crick and Brenner on 15 April 1960 during a conversation with François Jacob that messenger RNA was not the same thing as ribosomal RNA . Later that summer, Brenner, Jacob, and Matthew Meselson conducted an experiment which
16200-745: The laboratory of David Harker at Brooklyn Polytechnic Institute , where he continued to develop his skills in the analysis of X-ray diffraction data for proteins, working primarily on ribonuclease and the mechanisms of protein synthesis . David Harker, the American X-ray crystallographer, was described as "the John Wayne of crystallography" by Vittorio Luzzati, a crystallographer at the Centre for Molecular Genetics in Gif-sur-Yvette near Paris, who had worked with Rosalind Franklin. After
16362-414: The last person so honoured. Honorary members form another group, to which there is no numerical limit, though such appointments are rare; individuals from countries in the Commonwealth of Nations that are not headed by King Charles are therefore considered foreigners, and thus are granted only honorary admissions, such as Nelson Mandela (South Africa) and Mother Teresa (India). Upon admission into
16524-405: The letter "My Dear Michael, Jim Watson and I have probably made a most important discovery". The letter was put up for auction at Christie's New York on 10 April 2013 with an estimate of $ 1 to $ 2 million, eventually selling for $ 6,059,750, the largest amount ever paid for a letter at auction. Sydney Brenner , Jack Dunitz , Dorothy Hodgkin , Leslie Orgel , and Beryl M Oughton, were some of
16686-481: The model of the structure of DNA. Orgel also later worked with Crick at the Salk Institute for Biological Studies . Crick was often described as very talkative, with Watson – in The Double Helix – implying lack of modesty. His personality combined with his scientific accomplishments produced many opportunities for Crick to stimulate reactions from others, both inside and outside the scientific world, which
16848-495: The molecular structure of large molecules like proteins and DNA, but there were serious technical problems then preventing X-ray crystallography from being applicable to such large molecules. Crick taught himself the mathematical theory of X-ray crystallography. During the period of Crick's study of X-ray diffraction , researchers in the Cambridge lab were attempting to determine the most stable helical conformation of amino acid chains in proteins (the alpha helix ). Linus Pauling
17010-468: The molecule had a helical structure—but Franklin vehemently disputed this conclusion. Stimulated by their discussions with Wilkins and what Watson learned by attending a talk given by Franklin about her work on DNA, Crick and Watson produced and showed off an erroneous first model of DNA. Their hurry to produce a model of DNA structure was driven in part by the knowledge that they were competing against Linus Pauling. Given Pauling's recent success in discovering
17172-688: The monarch's decision on appointments. But, the Royal Household adamantly guarded information about potential names. After 1931, when the Statute of Westminster came into effect and the Dominions of the British Empire became independent countries within the empire, equal in status to the UK, the Order of Merit continued as an honour open to all these realms and, in many, became a part of their newly developing national honours systems. The order's statutes were amended in 1935 to include members of
17334-740: The morning of 28 July 2004 at the University of California, San Diego (UCSD) Thornton Hospital in La Jolla; he was cremated and his ashes were scattered into the Pacific Ocean. A public memorial was held on 27 September 2004 at the Salk Institute , La Jolla, near San Diego, California; guest speakers included James Watson , Sydney Brenner , Alex Rich , Seymour Benzer , Aaron Klug , Christof Koch , Pat Churchland , Vilayanur Ramachandran , Tomaso Poggio , Leslie Orgel , Terry Sejnowski , his son Michael Crick, and his younger daughter Jacqueline Nichols. A private memorial for family and colleagues
17496-484: The next day; Victor K. McElheny , in researching his biography, "Watson and DNA: Making a Scientific Revolution", found a clipping of a six-paragraph New York Times article written from London and dated 16 May 1953 with the headline "Form of 'Life Unit' in Cell Is Scanned". The article ran in an early edition and was then pulled to make space for news deemed more important. ( The New York Times subsequently ran
17658-469: The non-living to the living, and how the brain makes a conscious mind. He realised that his background made him more qualified for research on the first topic and the field of biophysics . It was at this time of Crick's transition from physics to biology that he was influenced by both Linus Pauling and Erwin Schrödinger . It was clear in theory that covalent bonds in biological molecules could provide
17820-568: The order remains the personal gift of its Sovereign—currently Edward VII's great-great-grandson Charles III —and is restricted to a maximum of 24 living recipients from the Commonwealth realms, plus honorary members. While all members are awarded the right to use the post-nominal letters OM and wear the badge of the order, the Order of Merit's precedence among other honours differs between countries. In around 1773, George III considered establishing an order of knighthood to be called
17982-514: The organising principle of what became known as molecular biology. Crick had by this time become a highly influential theoretical molecular biologist. Proof that the genetic code is a degenerate triplet code finally came from genetics experiments, some of which were performed by Crick. The details of the code came mostly from work by Marshall Nirenberg and others who synthesized synthetic RNA molecules and used them as templates for in vitro protein synthesis. Nirenberg first announced his results to
18144-502: The permanent members of its security council . The Soviet Union and the United States emerged as rival superpowers , setting the stage for the Cold War . In the wake of European devastation, the influence of its great powers waned, triggering the decolonisation of Africa and Asia . Most countries whose industries had been damaged moved towards economic recovery and expansion . World War II began in Europe on 1 September 1939 with
18306-589: The political European map with the defeat of the Central Powers —including Austria-Hungary , Germany , Bulgaria , and the Ottoman Empire —and the 1917 Bolshevik seizure of power in Russia , which led to the founding of the Soviet Union. Meanwhile, the victorious Allies of World War I , such as France, Belgium, Italy, Romania, and Greece, gained territory, and new nation-states were created out of
18468-599: The port of Tobruk . By late March 1941, Bulgaria and Yugoslavia signed the Tripartite Pact ; however, the Yugoslav government was overthrown two days later by pro-British nationalists. Germany and Italy responded with simultaneous invasions of both Yugoslavia and Greece , commencing on 6 April 1941; both nations were forced to surrender within the month. The airborne invasion of the Greek island of Crete at
18630-555: The post-nominal letters KMS , and the Order of Artistic Merit, for Knights of Merit in Art, with the post-nominal letters KMA . However, Frederic Leighton , President of the Royal Academy of Arts , advised against the new order, primarily because of its selection process. It was Victoria's son Edward VII who eventually founded the Order of Merit on 26 June 1902 (the date for which his coronation had been originally scheduled ) as
18792-399: The predominant tautomers of the pyrimidine (C and T) bases would be the amine and keto configurations of cytosine and thymine, rather than the imino and enol forms that Crick and Watson had assumed. They consulted Jerry Donohue who confirmed the most likely structures of the nucleotide bases. The base pairs are held together by hydrogen bonds , the same non-covalent interaction that stabilise
18954-462: The protein α-helix. The correct structures were essential for the positioning of the hydrogen bonds. These insights led Watson to deduce the true biological relationships of the A:T and C:G pairs. After the discovery of the hydrogen bonded A:T and C:G pairs, Watson and Crick soon had their anti-parallel, double helical model of DNA, with the hydrogen bonds at the core of the helix providing a way to "unzip"
19116-447: The reigning monarch of the realms, currently Charles III , with the assistance of his private secretaries; the order has thus been described as "quite possibly, the most prestigious honour one can receive on planet Earth." Within the limited membership is a designated military division, with its own unique insignia; though it has not been abolished, it is currently unpopulated, Louis Mountbatten, 1st Earl Mountbatten of Burma having been
19278-722: The remainder of Czechoslovakia and subsequently split it into the German Protectorate of Bohemia and Moravia and a pro-German client state , the Slovak Republic . Hitler also delivered an ultimatum to Lithuania on 20 March 1939, forcing the concession of the Klaipėda Region , formerly the German Memelland . Greatly alarmed and with Hitler making further demands on the Free City of Danzig ,
19440-414: The reverse bears the royal cypher of the reigning monarch in gold. The insignia for the military grouping is distinguished by a pair of crossed swords behind the central disk. The ribbon of the Order of Merit is divided into two stripes of red and blue. The neck ribbon is 50mm in width, while the ribbon bar width is the standard British 32mm size for military or civilian wear. Men wear their badges on
19602-400: The salience of this important fact for Watson and Crick. The significance of these ratios for the structure of DNA were not recognised until Watson, persisting in building structural models, realised that A:T and C:G pairs are structurally similar. In particular, the length of each base pair is the same. Chargaff had also pointed out to Watson that, in the aqueous, saline environment of the cell,
19764-553: The scientific study of human consciousness. He remained in this post until his death; "he was editing a manuscript on his death bed, a scientist until the bitter end" according to Christof Koch . Crick was the first son of Harry Crick and Annie Elizabeth Crick (née Wilkins). He was born on 8 June 1916 and raised in Weston Favell , then a small village near the English town of Northampton , in which Crick's father and uncle ran
19926-410: The significant territorial, colonial, and financial losses imposed by the Treaty of Versailles . Under the treaty, Germany lost around 13 percent of its home territory and all its overseas possessions , while German annexation of other states was prohibited, reparations were imposed, and limits were placed on the size and capability of the country's armed forces . The German Empire was dissolved in
20088-498: The start or prelude to World War II. The exact date of the war's end also is not universally agreed upon. It was generally accepted at the time that the war ended with the armistice of 15 August 1945 ( V-J Day ), rather than with the formal surrender of Japan on 2 September 1945, which officially ended the war in Asia . A peace treaty between Japan and the Allies was signed in 1951. A 1990 treaty regarding Germany's future allowed
20250-593: The strong Maginot Line fortifications on the Franco-German border, Germany directed its attack at the neutral nations of Belgium , the Netherlands , and Luxembourg . The Germans carried out a flanking manoeuvre through the Ardennes region, which was mistakenly perceived by the Allies as an impenetrable natural barrier against armoured vehicles. By successfully implementing new Blitzkrieg tactics,
20412-399: The structural stability needed to hold genetic information in cells. It only remained as an exercise of experimental biology to discover exactly which molecule was the genetic molecule. In Crick's view, Charles Darwin's theory of evolution by natural selection , Gregor Mendel 's genetics and knowledge of the molecular basis of genetics, when combined, revealed the secret of life. Crick had
20574-485: The structure of collagen . However, Crick was quickly drifting away from continued work related to his expertise in the interpretation of X-ray diffraction patterns of proteins. George Gamow established a group of scientists interested in the role of RNA as an intermediary between DNA as the genetic storage molecule in the nucleus of cells and the synthesis of proteins in the cytoplasm (the RNA Tie Club ). It
20736-509: The structure of DNA. Late in 1951, Crick started working with James Watson at Cavendish Laboratory at the University of Cambridge , England. Using " Photo 51 " (the X-ray diffraction results of Rosalind Franklin and her graduate student Raymond Gosling of King's College London, given to them by Gosling and Franklin's colleague Wilkins), Watson and Crick together developed a model for a helical structure of DNA, which they published in 1953. For this and subsequent work they were jointly awarded
20898-497: The subject. Though nothing came of the idea at the time, the concept did not wither and, more than 40 years later, on 5 January 1888, Prime Minister Robert Gascoyne-Cecil, 3rd Marquess of Salisbury submitted to the by then long-widowed Queen a draft constitution for an Order of Merit in Science and Art, consisting of one grade split into two branches of knighthood: the Order of Scientific Merit, for Knights of Merit in Science, with
21060-410: The triplets were used, "magically" producing just the 20 needed combinations. Experimental results were needed; theory alone could not decide the nature of the code. Crick also used the term " central dogma " to summarise an idea that implies that genetic information flow between macromolecules would be essentially one-way: Some critics thought that by using the word "dogma", Crick was implying that this
21222-422: The two complementary strands for easy replication : the last key requirement for a likely model of the genetic molecule. As important as Crick's contributions to the discovery of the double helical DNA model were, he stated that without the chance to collaborate with Watson, he would not have found the structure by himself. Crick did tentatively attempt to perform some experiments on nucleotide base pairing, but he
21384-585: The two wars became World War II in 1941. Other proposed starting dates for World War II include the Italian invasion of Abyssinia on 3 October 1935. The British historian Antony Beevor views the beginning of World War II as the Battles of Khalkhin Gol fought between Japan and the forces of Mongolia and the Soviet Union from May to September 1939. Others view the Spanish Civil War as
21546-447: The very optimistic view that life would very soon be created in a test tube. However, some people (such as fellow researcher and colleague Esther Lederberg ) thought that Crick was unduly optimistic. It was clear that some macromolecule such as a protein was likely to be the genetic molecule. However, it was well known that proteins are structural and functional macromolecules, some of which carry out enzymatic reactions of cells. In
21708-513: The war were not fulfilled in the peace settlement. From 1922 to 1925, the Fascist movement led by Benito Mussolini seized power in Italy with a nationalist, totalitarian , and class collaborationist agenda that abolished representative democracy, repressed socialist, left-wing, and liberal forces, and pursued an aggressive expansionist foreign policy aimed at making Italy a world power, promising
21870-475: The war. Germany annexed western Poland and occupied central Poland ; the Soviet Union annexed eastern Poland ; small shares of Polish territory were transferred to Lithuania and Slovakia . On 6 October, Hitler made a public peace overture to the United Kingdom and France but said that the future of Poland was to be determined exclusively by Germany and the Soviet Union. The proposal was rejected and Hitler ordered an immediate offensive against France, which
22032-512: The west halted the German advance for several days, but it was outflanked and encircled by the Wehrmacht . Remnants of the Polish army broke through to besieged Warsaw . On 17 September 1939, two days after signing a cease-fire with Japan , the Soviet Union invaded Poland under the supposed pretext that the Polish state had ceased to exist. On 27 September, the Warsaw garrison surrendered to
22194-413: The wetter B form). Wilkins shared this information about the B form of DNA with Crick and Watson. Crick did not see Franklin's B form X-ray images ( Photo 51 ) until after the DNA double helix model was published. One of the few references cited by Watson and Crick when they published their model of DNA was to a published article that included Sven Furberg's DNA model that had the bases on the inside. Thus,
22356-707: The world order , and soon began a massive rearmament campaign . France, seeking to secure its alliance with Italy, allowed Italy a free hand in Ethiopia , which Italy desired as a colonial possession. The situation was aggravated in early 1935 when the Territory of the Saar Basin was legally reunited with Germany, and Hitler repudiated the Treaty of Versailles, accelerated his rearmament programme, and introduced conscription. The United Kingdom, France and Italy formed
22518-553: The youngest person ever inducted into the Order, having been admitted by Queen Elizabeth II in 1968, when he was 47 years old. Robin Eames , Baron Eames represented the order at the coronation of Charles III and Camilla on 6 May 2023. All citizens of the Commonwealth realms are eligible for appointment to the Order of Merit. There may be, however, only 24 living individuals in the order at any given time, not including honorary appointees, and new members are personally selected by
22680-614: Was invaded by Germany. The United States started strategic planning to prepare for a full-scale offensive against Germany. At the end of September 1940, the Tripartite Pact formally united Japan, Italy, and Germany as the Axis powers . The Tripartite Pact stipulated that any country—with the exception of the Soviet Union—that attacked any Axis Power would be forced to go to war against all three. The Axis expanded in November 1940 when Hungary , Slovakia , and Romania joined. Romania and Hungary later made major contributions to
22842-462: Was a global conflict between two coalitions: the Allies and the Axis powers . Nearly all the world's countries —including all the great powers —participated, with many investing all available economic, industrial, and scientific capabilities in pursuit of total war , blurring the distinction between military and civilian resources. Tanks and aircraft played major roles , with the latter enabling
23004-498: Was a corresponding set of small "adaptor molecules" that would hydrogen bond to short sequences of a nucleic acid, and also link to one of the amino acids. He also explored the many theoretical possibilities by which short nucleic acid sequences might code for the 20 amino acids. During the mid-to-late 1950s Crick was very much intellectually engaged in sorting out the mystery of how proteins are synthesised. By 1958, Crick's thinking had matured and he could list in an orderly way all of
23166-404: Was a rule that could not be questioned, but all he really meant was that it was a compelling idea without much solid evidence to support it. In his thinking about the biological processes linking DNA genes to proteins, Crick made explicit the distinction between the materials involved, the energy required, and the information flow. Crick was focused on this third component (information) and it became
23328-503: Was about 1.25 mi (2 km) from his home so he could walk there and back, by Park Avenue South and Abington Park Crescent, but he more often went by bus or, later, by bicycle. The teaching in the higher forms was satisfactory, but not as stimulating. After the age of 14, he was educated at Mill Hill School in London (on a scholarship), where he studied mathematics, physics , and chemistry with his best friend John Shilston. He shared
23490-513: Was clear to Crick that there had to be a code by which a short sequence of nucleotides would specify a particular amino acid in a newly synthesised protein. In 1956, Crick wrote an informal paper about the genetic coding problem for the small group of scientists in Gamow's RNA group. In this article, Crick reviewed the evidence supporting the idea that there was a common set of about 20 amino acids used to synthesise proteins. Crick proposed that there
23652-888: Was deflected from a possible career in physics. During his second year as a PhD student, however, he was awarded the Carey Foster Research Prize, a great honour. He did postdoctoral work at the Brooklyn Collegiate and Polytechnic Institute , now part of the New York University Tandon School of Engineering . During World War II, he worked for the Admiralty Research Laboratory , from which many notable scientists emerged, including David Bates , Robert Boyd , Thomas Gaskell , George Deacon , John Gunn , Harrie Massey , and Nevill Mott ; he worked on
23814-480: Was going to the new job, and that Linus Pauling was working on the structure of DNA, they were willing to share Franklin's data with Watson and Crick, in the hope that they could find a good model of DNA before Pauling was able. Franklin's X-ray diffraction data for DNA and her systematic analysis of DNA's structural features were useful to Watson and Crick in guiding them towards a correct molecular model. The key problem for Watson and Crick, which could not be resolved by
23976-593: Was held on 3 August 2004. Crick's Nobel Prize medal and diploma from the Nobel committee was sold at auction in June 2013 for $ 2,270,000. It was bought by Jack Wang, the CEO of Chinese medical company Biomobie. 20% of the sale price of the medal was donated to the Francis Crick Institute in London. Crick was interested in two fundamental unsolved problems of biology: how molecules make the transition from
24138-482: Was made on 28 February 1953; the first Watson/Crick paper appeared in Nature on 25 April 1953. Sir Lawrence Bragg, the director of the Cavendish Laboratory , where Watson and Crick worked, gave a talk at Guy's Hospital Medical School in London on Thursday 14 May 1953 which resulted in an article by Ritchie Calder in the News Chronicle of London, on Friday 15 May 1953, entitled "Why You Are You. Nearer Secret of Life." The news reached readers of The New York Times
24300-433: Was more of a theoretical biologist than an experimental biologist. There was another near-discovery of the base pairing rules in early 1952. Crick had started to think about interactions between the bases. He asked John Griffith to try to calculate attractive interactions between the DNA bases from chemical principles and quantum mechanics . Griffith's best guess was that A:T and G:C were attractive pairs. At that time, Crick
24462-428: Was not aware of Chargaff's rules and he made little of Griffith's calculations, although it did start him thinking about complementary replication. Identification of the correct base-pairing rules (A-T, G-C) was achieved by Watson "playing" with cardboard cut-out models of the nucleotide bases, much in the manner that Linus Pauling had discovered the protein alpha helix a few years earlier. The Watson and Crick discovery of
24624-435: Was one of only eight references in Franklin's first paper on DNA. Analysis of Astbury's published DNA results and the better X-ray diffraction images collected by Wilkins and Franklin revealed the helical nature of DNA. It was possible to predict the number of bases stacked within a single turn of the DNA helix (10 per turn; a full turn of the helix is 27 angströms [2.7 nm] in the compact A form, 34 angströms [3.4 nm] in
24786-403: Was postponed until the spring of 1940 due to bad weather. After the outbreak of war in Poland, Stalin threatened Estonia , Latvia , and Lithuania with military invasion, forcing the three Baltic countries to sign pacts allowing the creation of Soviet military bases in these countries; in October 1939, significant Soviet military contingents were moved there. Finland refused to sign
24948-465: Was preoccupied with proteins at the time, not DNA. Watson and Crick were not officially working on DNA. Crick was writing his PhD thesis; Watson also had other work such as trying to obtain crystals of myoglobin for X-ray diffraction experiments. In 1952, Watson performed X-ray diffraction on tobacco mosaic virus and found results indicating that it had helical structure. Having failed once, Watson and Crick were now somewhat reluctant to try again and for
25110-657: Was repulsed with heavy Italian casualties; the campaign ended within months with minor territorial changes. To assist Italy and prevent Britain from gaining a foothold, Germany prepared to invade the Balkans, which would threaten Romanian oil fields and strike against British dominance of the Mediterranean. In December 1940, British Empire forces began counter-offensives against Italian forces in Egypt and Italian East Africa . The offensives were successful; by early February 1941, Italy had lost control of eastern Libya, and large numbers of Italian troops had been taken prisoner. The Italian Navy also suffered significant defeats, with
25272-441: Was required to go through the bureaucracy of the League of Nations, which rendered it essentially toothless. The United States, concerned with events in Europe and Asia, passed the Neutrality Act in August of the same year. Hitler defied the Versailles and Locarno Treaties by remilitarising the Rhineland in March 1936, encountering little opposition due to the policy of appeasement . In October 1936, Germany and Italy formed
25434-406: Was structurally uninteresting and possibly just a molecular scaffold for the apparently more interesting protein molecules. Crick was in the right place, in the right frame of mind, at the right time (1949), to join Max Perutz's project at the University of Cambridge , and he began to work on the X-ray crystallography of proteins. X-ray crystallography theoretically offered the opportunity to reveal
25596-475: Was the centre of his intellectual and professional life. Crick spoke rapidly, and rather loudly, and had an infectious and reverberating laugh, and a lively sense of humour. One colleague from the Salk Institute described him as "a brainstorming intellectual powerhouse with a mischievous smile. ... Francis was never mean-spirited, just incisive. He detected microscopic flaws in logic. In a room full of smart scientists, Francis continually re-earned his position as
25758-471: Was the first to identify the 3.6 amino acids per helix turn ratio of the alpha helix. Crick was witness to the kinds of errors that his co-workers made in their failed attempts to make a correct molecular model of the alpha helix; these turned out to be important lessons that could be applied, in the future, to the helical structure of DNA. For example, he learned the importance of the structural rigidity that double bonds confer on molecular structures which
25920-544: Was the first to prove the existence of messenger RNA. None of this, however, answered the fundamental theoretical question of the exact nature of the genetic code. In his 1958 article, Crick speculated, as had others, that a triplet of nucleotides could code for an amino acid. Such a code might be "degenerate", with 4×4×4=64 possible triplets of the four nucleotide subunits while there were only 20 amino acids. Some amino acids might have multiple triplet codes. Crick also explored other codes in which, for various reasons, only some of
26082-596: Was under the direction of Randall. (Randall had refused Crick's application to work at King's College.) Francis Crick and Maurice Wilkins of King's College were personal friends, which influenced subsequent scientific events as much as the close friendship between Crick and James Watson . Crick and Wilkins first met at King's College and not, as erroneously recorded by two authors, at the Admiralty during World War II. Crick married twice and fathered three children; his brother Anthony (born in 1918) predeceased him in 1966. Spouses: Children: Crick died of colon cancer on
26244-486: Was under the general direction of Sir Lawrence Bragg , who had won the Nobel Prize in 1915 at the age of 25. Bragg was influential in the effort to beat a leading American chemist, Linus Pauling , to the discovery of DNA 's structure (after having been pipped at the post by Pauling's success in determining the alpha helix structure of proteins). At the same time Bragg's Cavendish Laboratory was also effectively competing with King's College London , whose Biophysics department
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