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Louis Pasteur

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119-428: Louis Pasteur ForMemRS ( / ˈ l uː i p æ ˈ s t ɜːr / , French: [lwi pastœʁ] ; 27 December 1822 – 28 September 1895) was a French chemist , pharmacist , and microbiologist renowned for his discoveries of the principles of vaccination , microbial fermentation , and pasteurization , the last of which was named after him. His research in chemistry led to remarkable breakthroughs in

238-496: A Catholic family of a poor tanner . He was the third child of Jean-Joseph Pasteur and Jeanne-Etiennette Roqui. The family moved to Marnoz in 1826 and then to Arbois in 1827. Pasteur entered primary school in 1831. He was dyslexic and dysgraphic . He was an average student in his early years, and not particularly academic, as his interests were fishing and sketching . He drew many pastels and portraits of his parents, friends and neighbors. Pasteur attended secondary school at

357-477: A Place d'Armes and dating from the 18th and 19th centuries. It currently houses the headquarters of the 1st Armored Division and the 7th Armoured Brigade . After the city acquired an episcopal see in the 3rd century, churches and abbeys multiplied during the period of the High Middle Ages . Important constructions or reconstructions of religious buildings then took place in the 11th century during

476-417: A chemist , beginning at the École Normale Supérieure , and continuing at Strasbourg and Lille, he examined the chemical, optical and crystallographic properties of a group of compounds known as tartrates . He resolved a problem concerning the nature of tartaric acid in 1848. A solution of this compound derived from living things rotated the plane of polarization of light passing through it. The problem

595-763: A Chair (all of whom are Fellows of the Royal Society ). Members of the 10 Sectional Committees change every three years to mitigate in-group bias . Each Sectional Committee covers different specialist areas including: New Fellows are admitted to the Society at a formal admissions day ceremony held annually in July, when they sign the Charter Book and the Obligation which reads: "We who have hereunto subscribed, do hereby promise, that we will endeavour to promote

714-452: A little-known specialty, automatic ticketing machines for car parking, airports, date stamping etc. The watch industry, for which Besançon remains the French capital, endured a major crisis in the 1970s when the advent of quartz watches from Asia knocked out the traditional watch industry in the space of just a few years. The "Lip" affair epitomizes the industrial crisis. LIP is to this day

833-404: A long time to recover from the collapse of the watch industry and its other major industry of the industrial age, artificial textiles. Since the 1980s, Besançon's watch industry has clawed its way back on the basis of its historic reputation and quartz watches, establishing itself in a number of niche markets including customized watches, high quality watches, and fashion articles. Since the 1990s,

952-497: A microscope, and if corpuscles were observed, the eggs were destroyed. Pasteur concluded that bacteria caused flacherie. The primary cause is currently thought to be viruses. The spread of flacherie could be accidental or hereditary. Hygiene could be used to prevent accidental flacherie. Moths whose digestive cavities did not contain the microorganisms causing flacherie were used to lay eggs, preventing hereditary flacherie. Following his fermentation experiments, Pasteur demonstrated that

1071-406: A mutton stew, which students had refused to eat, would be served and eaten every Monday. On another occasion he threatened to expel any student caught smoking, and 73 of the 80 students in the school resigned. In 1863, he was appointed professor of geology, physics, and chemistry at the École nationale supérieure des Beaux-Arts , a position he held until his resignation in 1867. In 1867, he became

1190-536: A new chicken cholera culture using bacteria from a culture that had sat since July. The two chickens inoculated with this new culture showed some symptoms of infection, but instead of the infections being fatal, as they usually were, the chickens recovered completely. After further incubation of the culture for an additional 8 days, Roux again inoculated the same two chickens. As was also noted by Pasteur in his notebook in March of 1880, and contrary to some accounts, this time

1309-620: A new disease that was decimating silkworm farms from the south of France and Europe, the pébrine , characterized on a macroscopic scale by black spots and on a microscopic scale by the " Cornalia corpuscles". Pasteur accepted and made five long stays in Alès , between 7 June 1865 and 1869. Arriving in Alès, Pasteur familiarized himself with pébrine and also with another disease of the silkworm, known earlier than pebrine: flacherie or dead-flat disease. Contrary, for example, to Quatrefages , who coined

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1428-402: A note published on 27 August 1866 by Balbiani , which Pasteur at first seemed to welcome favourably had no effect, at least immediately. "Pasteur is mistaken. He would only change his mind in the course of 1867". At a time where Pasteur had not yet understood the cause of the pébrine, he propagated an effective process to stop infections: a sample of chrysalises was chosen, they were crushed and

1547-877: A private company built a funicular to the Brégille Heights. The funicular passed from private ownership to the SNCF , who finally closed it in 1987. The funicular's tracks, stations and even road signs remain in place to this day. Besançon is located in the north-east quarter of France on the river Doubs. It is about 325 kilometres (202 miles) east of the national capital of Paris, 100 kilometres (62 miles) east of Dijon in Burgundy, 125 km (78 mi) northwest of Lausanne in Switzerland, and 100 km (62 mi) southwest of Belfort in Franche-Comté. It

1666-563: A rocky outcrop, is the work of the Romans. It marks the entrance to the city on the road to Switzerland. It is surmounted by a guardhouse and a watchtower built in 1546. The “square tower”, located in the promenade des Glacis, is also called the Montmart tower. It was built in the 13th century to defend the old entrance to the Battant district. The fortifications of the 19th century consist of

1785-544: A set of forts covering all the heights of the city: the fort of Chaudanne built from 1837 to 1842, the fort of Bregille built from 1820 to 1832, the fort of Planoise built from 1877 to 1880, Fort Benoit was built from 1877 to 1880, Fort Beauregard in 1830. Another example are the Trois-Châtels and Tousey lunettes , both built at the end of the 18th and early 19th centuries, as well as the Rosemont battery built during

1904-538: A speech to the French Academy of Sciences on 28 February. On 21 March, despite inconsistent results, he announced successful vaccination of sheep. To this news, veterinarian Hippolyte Rossignol proposed that the Société d'agriculture de Melun organize an experiment to test Pasteur's vaccine. Pasteur signed an agreement accepting the challenge on 28 April. Pasteur's assistants, Roux and Chamberland, who were assigned

2023-412: A vaccine for anthrax was greatly stimulated when on 12 July 1880, Henri Bouley read before the French Academy of Sciences a report from Henry Toussaint , a veterinary surgeon , who was not a member of the academy. Toussaint had developed anthrax vaccine by killing the bacilli by heating at 55 °C for 10  minutes. He tested his vaccine on eight dogs and 11 sheep, half of which died after inoculation. It

2142-559: Is a barge canal that cuts through rock under Mont Saint-Étienne, short-cutting the meander.) Besançon has an oceanic climate ( Köppen : Cfb , Trewartha : Do ), with cool to cold winters, warm summers, and frequent precipitation year-round. The year-round average is 11.5 °C (53 °F). The warmest month is July with an average temperature of 20 °C (68 °F), and the coldest is January, with an average temperature of 2 °C (36 °F). Besançon receives about 1,059 mm (42 in) of precipitation per year. As of 2021,

2261-1326: Is a significant honour. It has been awarded to many eminent scientists throughout history, including Isaac Newton (1672), Benjamin Franklin (1756), Charles Babbage (1816), Michael Faraday (1824), Charles Darwin (1839), Ernest Rutherford (1903), Srinivasa Ramanujan (1918), Jagadish Chandra Bose (1920), Albert Einstein (1921), Paul Dirac (1930), Winston Churchill (1941), Subrahmanyan Chandrasekhar (1944), Prasanta Chandra Mahalanobis (1945), Dorothy Hodgkin (1947), Alan Turing (1951), Lise Meitner (1955), Satyendra Nath Bose (1958), and Francis Crick (1959). More recently, fellowship has been awarded to Stephen Hawking (1974), David Attenborough (1983), Tim Hunt (1991), Elizabeth Blackburn (1992), Raghunath Mashelkar (1998), Tim Berners-Lee (2001), Venki Ramakrishnan (2003), Atta-ur-Rahman (2006), Andre Geim (2007), Bai Chunli (2014), James Dyson (2015), Ajay Kumar Sood (2015), Subhash Khot (2017), Elon Musk (2018), Elaine Fuchs (2019) and around 8,000 others in total, including over 280 Nobel Laureates since 1900. As of October 2018 , there are approximately 1,689 living Fellows, Foreign and Honorary Members, of whom 85 are Nobel Laureates. Fellowship of

2380-526: Is also the seat of one of the fifteen French ecclesiastical provinces and one of the two divisions of the French Army . In 2021 the city had a population of 119,198, in a metropolitan area of 283,127, the second in the region in terms of population. Established in a meander of the river Doubs , the city was already important during the Gallo-Roman era under the name of Vesontio , capital of

2499-412: Is an alcoholic ferment, the yeast of beer, which is found everywhere that sugar is decomposed into alcohol and carbonic acid, so also there is a particular ferment, a lactic yeast , always present when sugar becomes lactic acid ." Pasteur also wrote about alcoholic fermentation. It was published in full form in 1858. Jöns Jacob Berzelius and Justus von Liebig had proposed the theory that fermentation

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2618-737: Is confirmed by the Council in April, and a secret ballot of Fellows is held at a meeting in May. A candidate is elected if they secure two-thirds of votes of those Fellows voting. An indicative allocation of 18 Fellowships can be allocated to candidates from Physical Sciences and Biological Sciences; and up to 10 from Applied Sciences, Human Sciences and Joint Physical and Biological Sciences. A further maximum of six can be 'Honorary', 'General' or 'Royal' Fellows. Nominations for Fellowship are peer reviewed by Sectional Committees, each with at least 12 members and

2737-529: Is first recorded in 58 BC as Vesontio in Book I of Julius Caesar 's Commentarii de Bello Gallico . The etymology of Vesontio is uncertain. The most common explanation is that the name is of Celtic origin, derived from wes , meaning 'mountain'. During the 4th century, the letter B took the place of the V, and the city name changed to Besontio or Bisontion and then underwent several transformations to become Besançon in 1243. The city sits within an oxbow of

2856-633: Is located at the edge of the Jura Mountains . The city initially developed in a natural meander (or oxbow loop) of the river Doubs with a diameter of almost 1,000 metres (3,281 feet). The flat inner loop has an elevation of about 250 metres (820 feet), and is bounded to the south by a hill called Mont Saint-Étienne , which has a maximum height of 371 metres (1,217 feet). The city is surrounded by six other hills which range in elevation from 400 to 500 metres (1,312 to 1,640 feet): Brégille, Griffon, Planoise , Chaudanne, Montfaucon, and Montboucon. (There

2975-421: Is nominated by two Fellows of the Royal Society (a proposer and a seconder), who sign a certificate of proposal. Previously, nominations required at least five fellows to support each nomination by the proposer, which was criticised for supposedly establishing an old boy network and elitist gentlemen's club . The certificate of election (see for example ) includes a statement of the principal grounds on which

3094-590: Is the Porte Noire , a Gallo-Roman triumphal arch built under Marcus Aurelius in the 2nd century in the Saint-Jean district. Heavily deteriorated by the vagaries of time and pollution, it was the subject of a long and difficult restoration operation at the beginning of the 21st century. Immediately below is the Square Castan, a garden with a collection of archaeological remains from the 2nd century or

3213-541: Is the prefecture of the department of Doubs in the region of Bourgogne-Franche-Comté . The city is located in Eastern France, close to the Jura Mountains and the border with Switzerland . Capital of the historic and cultural region of Franche-Comté , Besançon is home to the Bourgogne-Franche-Comté regional council headquarters, and is an important administrative centre in the region. It

3332-527: Is the work of the military engineer Sébastien Le Prestre de Vauban . This group of buildings allows Besançon to appear on the UNESCO World Heritage List with eleven other sites under the title Fortifications of Vauban . The forts on the other hills were all built in the 19th century. The only remaining pre-Vauban fortifications are Porte Rivotte, Porte Taillée, Tour Carrée, Tour Notre-Dame and Tour de la Pelote. The citadel of Besançon

3451-472: The baccalauréat scientifique (general science) degree from Dijon , where he earned his Bachelor of Science in Mathematics degree (Bachelier ès Sciences Mathématiques) in 1842, but with a mediocre grade in chemistry. Later in 1842, Pasteur took the entrance test for the École Normale Supérieure . During the test, he had to fight fatigue and only felt comfortable with physics and mathematics. He passed

3570-557: The licencié ès sciences degree. In 1846, he was appointed professor of physics at the Collège de Tournon (now called Lycée Gabriel-Faure ) in Ardèche . But the chemist Antoine Jérôme Balard wanted him back at the École Normale Supérieure as a graduate laboratory assistant ( agrégé préparateur ). He joined Balard and simultaneously started his research in crystallography and in 1847, he submitted his two theses, one in chemistry and

3689-701: The Arverni tribe and the Germanic Suebi tribe under the Germanic king Ariovistus . Julius Caesar , in his commentaries detailing his conquest of Gaul , describes Vesontio (possibly Latinized ), as the largest town of the Sequani , a smaller Gaulic tribe, and mentions that a wooden palisade surrounded it. It appears as Vesontine in the Tabula Peutingeriana . Over the centuries,

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3808-515: The Congrès international séricicole , Pasteur admitted that "if pébrine is overcome, flacherie still exerts its ravages". He attributed the persistence of flacherie to the fact that the farmers had not followed his advice. In 1884, Balbiani , who disregarded the theoretical value of Pasteur's work on silkworm diseases, acknowledged that his practical process had remedied the ravages of pébrine, but added that this result tended to be counterbalanced by

3927-669: The Haedui and their hereditary rivals, the Sequani . According to Strabo , the cause of the conflict was commercial. Each tribe claimed the Arar and the tolls on trade along it. The Sequani controlled access to the Rhine and had built an oppidum (a fortified town) at Vesontio to protect their interests. The Sequani defeated and massacred the Haedui at the Battle of Magetobriga , with the help of

4046-509: The Pasteur effect . Pasteur's research also showed that the growth of micro-organisms was responsible for spoiling beverages, such as beer, wine and milk. With this established, he invented a process in which liquids such as milk were heated to a temperature between 60 and 100 °C. This killed most bacteria and moulds already present within them. Pasteur and Claude Bernard completed tests on blood and urine on 20 April 1862. Pasteur patented

4165-552: The Sequani . Its geography and specific history turned it into a military stronghold, a garrison city, a political centre, and a religious capital. Besançon is the historical capital of watchmaking in France. This has led it to become a centre for innovative companies in the fields of microtechnology , micromechanics , and biomedical engineering . The University of Franche-Comté , founded in 1423, enrolls nearly 30,000 students each year, including around 4,000 trainees from all over

4284-518: The War of Devolution . Louis conquered the city for the first time in 1668, but the Treaty of Aix-la-Chapelle returned it to Spain within a matter of months. While it was in French hands, the famed military engineer Vauban visited the city and drew up plans for its fortification. The Spaniards built the main centre point of the city's defences, "la Citadelle", siting it on Mont Saint-Étienne, which closes

4403-426: The post-nominal letters FRS . Every year, fellows elect up to ten new foreign members. Like fellows, foreign members are elected for life through peer review on the basis of excellence in science. As of 2016 , there are around 165 foreign members, who are entitled to use the post-nominal ForMemRS . Honorary Fellowship is an honorary academic title awarded to candidates who have given distinguished service to

4522-412: The 17th and 18th centuries, respectively. Spallanzani's experiments in 1765 suggested that air contaminated broths with bacteria. In the 1860s, Pasteur repeated Spallanzani's experiments, but Pouchet reported a different result using a different broth. Pasteur performed several experiments to disprove spontaneous generation. He placed boiled liquid in a flask and let hot air enter the flask. Then he closed

4641-524: The 3rd century including in particular eight Corinthian columns . On the other bank of the river Doubs, in the Battant district, the remains of the Vesontio arena are visible: only a few steps and foundations have been unearthed, its stones having been widely used in the Middle Ages for the construction of other buildings. There are several domus in the residential district of Vesontio. Among them,

4760-464: The Academy two main consequences to the facts presented: the hope to culture all microbes and to find a vaccine for all infectious diseases that have repeatedly afflicted humanity, and are a major burden on agriculture and breeding of domestic animals. In fact, Pasteur's vaccine against chicken cholera did not consistently produce immunity, and has subsequently been proven to be ineffective. Following

4879-480: The Alhumbert Prize carrying 2,500 francs in 1862. Pasteur is also regarded as one of the fathers of germ theory of diseases , which was a minor medical concept at the time. His many experiments showed that diseases could be prevented by killing or stopping germs, thereby directly supporting the germ theory and its application in clinical medicine. He is best known to the general public for his invention of

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4998-615: The Collège d'Arbois. In October 1838, he left for Paris to enroll in a boarding school , but became homesick and returned in November. In 1839, he entered the Collège Royal at Besançon to study philosophy and earned his Bachelor of Letters degree in 1840. He was appointed a tutor at the Besançon college while continuing a degree science course with special mathematics. He failed his first examination in 1841. He managed to pass

5117-600: The Dijon Lycée in 1848, he became professor of chemistry at the University of Strasbourg , where he met and courted Marie Laurent , daughter of the university's rector in 1849. They were married on 29 May 1849, and together had five children, only two of whom survived to adulthood; the other three died of typhoid . Pasteur was appointed professor of chemistry at the University of Strasbourg in 1848, and became

5236-545: The Doctrine of Spontaneous Generation ). Pasteur won the Alhumbert Prize in 1862. He concluded that: Never will the doctrine of spontaneous generation recover from the mortal blow of this simple experiment. There is no known circumstance in which it can be confirmed that microscopic beings came into the world without germs, without parents similar to themselves. In 1865, Jean-Baptiste Dumas , chemist, senator and former Minister of Agriculture and Commerce, asked Pasteur to study

5355-730: The Duke of Burgundy . As part of the Holy Roman Empire since 1034, the city became an archbishopric , and was designated the Free Imperial City of Besançon (an autonomous city-state under the Holy Roman Emperor ) in 1184. In 1157, Emperor Frederick Barbarossa held the Diet of Besançon . There, Cardinal Orlando Bandinelli (the future Pope Alexander III, then adviser of Pope Adrian IV ) openly asserted before

5474-593: The Emperor that the imperial dignity was a papal beneficium (in the more general sense of favour, not the strict feudal sense of fief ), which incurred the wrath of the German princes. He would have fallen on the spot under the battle-axe of his lifelong foe, Otto of Wittelsbach , had Frederick not intervened. The Archbishops were elevated to Princes of the Holy Roman Empire in 1288. The close connection to

5593-498: The Empire is reflected in the city's coat of arms. In 1290, after a century of fighting against the power of the archbishops, the Emperor granted Besançon its independence. In the 15th century, Besançon came under the influence of the dukes of Burgundy . After the marriage of Mary of Burgundy to Maximilian I, Holy Roman Emperor , the city was in effect a Habsburg fief. In 1519 Charles V, Holy Roman Emperor , King of Spain , became

5712-461: The Germans executed some one hundred French resistance fighters there. However, Besançon saw little action during the war. The allies bombed the railway complex in 1943, and the next year the Germans resisted the U.S. advance for four days. Besançon was also the location, between 1940 and 1941, of an Internment Camp ( Konzentrationslager ), Frontstalag 142 , also known as Caserne Vauban , which

5831-513: The Germans set up for 3–4,000 holders of British passports, all women and children. The conditions were harsh; many hundreds of internees died of pneumonia, diarrhea, food poisoning, dysentery, and frostbite. In 1959, the French Army turned the citadel over to the city of Besançon, which turned it into a museum. The forts of Brégille and Beauregard sit across the Doubs from the city. In 1913,

5950-468: The Holy Roman Emperor. This made him master of the Franche-Comté and Besançon, a francophone imperial city. In 1526 the city obtained the right to mint coins, which it continued to strike until 1673. Nevertheless, all coins bore the name of Charles V. When Charles V abdicated in 1555, he gave the Franche-Comté to his son, Philip II , King of Spain. Besançon remained a free imperial city under

6069-492: The Quai de Strasbourg, is a defensive tower built in 1546 by the municipal government on the orders of Charles V . Its name would come from the former owner of the land where it was built, Pierre Pillot, lord of Chenecey. The Porte Rivotte is a city gate dating from the 16th century, consisting of two round towers and a pediment carved with a sun which was King Louis XIV 's personal emblem. The Porte Taillée ("Carved Gate"), opened in

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6188-613: The Royal Society Fellowship of the Royal Society ( FRS , ForMemRS and HonFRS ) is an award granted by the Fellows of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge , including mathematics , engineering science , and medical science ". Fellowship of the Society, the oldest known scientific academy in continuous existence,

6307-439: The Royal Society has been described by The Guardian as "the equivalent of a lifetime achievement Oscar " with several institutions celebrating their announcement each year. Up to 60 new Fellows (FRS), honorary (HonFRS) and foreign members (ForMemRS) are elected annually in late April or early May, from a pool of around 700 proposed candidates each year. New Fellows can only be nominated by existing Fellows for one of

6426-663: The Society, we shall be free from this Obligation for the future". Since 2014, portraits of Fellows at the admissions ceremony have been published without copyright restrictions in Wikimedia Commons under a more permissive Creative Commons license which allows wider re-use. In addition to the main fellowships of the Royal Society (FRS, ForMemRS & HonFRS), other fellowships are available which are applied for by individuals, rather than through election. These fellowships are research grant awards and holders are known as Royal Society Research Fellows . In addition to

6545-792: The Université de Franche-Comté, is the first school created in the country specifically for the Biomedical engineering field. The city is also home of the École Nationale Supérieure de Mécanique et des Microtechniques (ENSMM), a technological school with a strong reputation in the fields of microtechnology and mechanics and the Centre for Applied Linguistics which teaches ten languages to non-native speakers (French, Arabic, Chinese, English, German, Italian, Japanese, Portuguese, Russian, Spanish) and any other known language on request. The Centre welcomes more than 4,000 students every year from all over

6664-526: The award of Fellowship (FRS, HonFRS & ForMemRS) and the Research Fellowships described above, several other awards, lectures and medals of the Royal Society are also given. Besan%C3%A7on Besançon ( UK : / ˈ b ɛ z ən s ɒ n / , US : / b ə ˈ z æ n s ən / , French: [bəzɑ̃sɔ̃] , Franco-Provençal: [bəzɑ̃ˈsɔ̃] ; archaic German : Bisanz ; Latin : Vesontio )

6783-453: The bacteria needed to grow. He thought oxidizing bacteria when sitting in culture broth for prolonged periods made them less virulent. However, Pasteur's laboratory found that anthrax bacillus was not easily weakened by culturing in air as it formed spores – unlike chicken cholera bacillus. In early 1881, his laboratory discovered that growing anthrax bacilli at about 42 °C made them unable to produce spores, and he described this method in

6902-428: The bacteria was the cause of the disease. Many cattle were dying of anthrax in "cursed fields". Pasteur was told that sheep that died from anthrax were buried in the field. Pasteur thought that earthworms might have brought the bacteria to the surface. He found anthrax bacteria in earthworms' excrement, showing that he was correct. He told the farmers not to bury dead animals in the fields. Pasteur's interest in creating

7021-612: The cause of science, but do not have the kind of scientific achievements required of Fellows or Foreign Members. Honorary Fellows include the World Health Organization's Director-General Tedros Adhanom Ghebreyesus (2022), Bill Bryson (2013), Melvyn Bragg (2010), Robin Saxby (2015), David Sainsbury, Baron Sainsbury of Turville (2008), Onora O'Neill (2007), John Maddox (2000), Patrick Moore (2001) and Lisa Jardine (2015). Honorary Fellows are entitled to use

7140-517: The chair of chemistry in 1852. In February 1854, so that he would have time to carry out work that could earn him the title of correspondent of the Institute, he got three months' paid leave with the help of a medical certificate of convenience. He extended the leave until 1 August, the date of the start of the exams. "I tell the Minister that I will go and do the examinations so as not to increase

7259-526: The chair of organic chemistry at the Sorbonne, but he later gave up the position because of poor health. In 1867, the École Normale's laboratory of physiological chemistry was created at Pasteur's request, and he was the laboratory's director from 1867 to 1888. In Paris, he established the Pasteur Institute in 1887, in which he was its director for the rest of his life. In Pasteur's early work as

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7378-573: The chickens died. Thus, although the attenuated bacteria did not provide immunity, these experiments provided important clues as to how bacteria could be artificially attenuated in the laboratory. As a result, upon Pasteur’s return to the laboratory, the focus of the research was directed at creating a vaccine through attenuation. In February of 1880, Pasteur presented his results to the French Academy of Sciences as " Sur les maladies virulentes et en particulier sur la maladie appelée vulgairement choléra des poules (On virulent diseases, and in particular on

7497-610: The citadel's fortifications, and those of the city. This process lasted until 1711, some 30 years, and the walls built then surround the city. Between the train station and the central city there is a complex moat system that now serves road traffic. Numerous forts, some of which date back to that time and that incorporate Vauban's designs elements sit on the six hills that surround the city: Fort de Trois Châtels, Fort Chaudanne, Fort du Petit Chaudanne, Fort Griffon, Fort des Justices, Fort de Beauregard and Fort de Brégille . The citadel itself has two dry moats, with an outer and inner court. In

7616-482: The corpuscles were searched for in the crushed material; if the proportion of corpuscular pupae in the sample was very low, the chamber was considered good for reproduction. This method of sorting "seeds" (eggs) is close to a method that Osimo had proposed a few years earlier, but whose trials had not been conclusive. By this process, Pasteur curbs pébrine and saves many of the silk industry in the Cévennes. In 1878, at

7735-502: The development of flacherie, which was less well known and more difficult to prevent. Despite Pasteur's success against pébrine, French sericulture had not been saved from damage. (See fr:Sériciculture in the French Misplaced Pages.) Pasteur's first work on vaccine development was on chicken cholera . He received the bacteria samples (later called Pasteurella multocida after him) from Henry Toussaint . Being unnable to conduct

7854-405: The disease commonly called chicken cholera)" and published it in the academy's journal ( Comptes-Rendus hebdomadaires des séances de l'Académie des Sciences ). He attributed that the bacteria were weakened by contact with oxygen. He explained that bacteria kept in sealed containers never lost their virulence, and only those exposed to air in culture media could be used as vaccine. Pasteur introduced

7973-534: The diseases of wine, and he published Études sur la Bière in 1876, concerning the diseases of beer. In the early 19th century, Agostino Bassi had shown that muscardine was caused by a fungus that infected silkworms. Since 1853, two diseases called pébrine and flacherie had been infecting great numbers of silkworms in southern France, and by 1865 they were causing huge losses to farmers. In 1865, Pasteur went to Alès and worked for five years until 1870. Silkworms with pébrine were covered in corpuscles. In

8092-692: The domus of the Palace of Justice and the domus of the Lumière college with Roman mosaic exhibited in situ at the Besançon Museum of Fine Arts and Archeology. Other remains can be seen in more anonymous places, such as the ancient foundations in the underground car park of the Bourgogne-Franche-Comté regional council. Most of the current fortification system ( citadel , defensive wall made up of ramparts and bastions , Fort Griffon)

8211-404: The embarrassment of the service. It is also so as not to leave to another a sum of 6 or 700 francs". In this same year 1854, he was named dean of the new faculty of sciences at University of Lille , where he began his studies on fermentation. It was on this occasion that Pasteur uttered his oft-quoted remark: " dans les champs de l'observation, le hasard ne favorise que les esprits préparés " ("In

8330-538: The evenings, the illuminated Citadelle stands above the city as a landmark and a testament to Vauban's genius as a military engineer . In 1814, the Austrians invaded and bombarded the city. It also occupied an important position during the Franco-Prussian War of 1870–71. In 1871, a project of Besançon Commune is engaged. The Nazis occupied the citadel during World War II . Between 1940 and 1944,

8449-463: The experiments himself due to a stroke in 1868, Pasteur relied heavily on his assistants Emile Roux and Charles Chamberland. The work with chicken cholera was initiated in 1877, and by the next year, Roux was able to maintain a stable culture using broths. As documented later by Pasteur in his notebook in March of 1880, in October of 1879, being delayed in returning to the laboratory due to his daughter’s wedding and ill health, he instructed Roux to start

8568-528: The fellowships described below: Every year, up to 52 new fellows are elected from the United Kingdom, the rest of the Commonwealth of Nations , and Ireland, which make up around 90% of the society. Each candidate is considered on their merits and can be proposed from any sector of the scientific community. Fellows are elected for life on the basis of excellence in science and are entitled to use

8687-538: The field of observation, chance favors only the prepared mind"). In 1857, he moved to Paris as the director of scientific studies at the École Normale Supérieure where he took control from 1858 to 1867 and introduced a series of reforms to improve the standard of scientific work. The examinations became more rigid, which led to better results, greater competition, and increased prestige. Many of his decrees, however, were rigid and authoritarian, leading to two serious student revolts. During "the bean revolt" he decreed that

8806-473: The first explanation of isomerism . Some historians consider Pasteur's work in this area to be his "most profound and most original contributions to science", and his "greatest scientific discovery." Pasteur was motivated to investigate fermentation while working at Lille. In 1856 a local wine manufacturer, M. Bigot, whose son was one of Pasteur's students, sought for his advice on the problems of making beetroot alcohol and souring. Pasteur began his research in

8925-582: The first set of tests, but because his ranking was low, Pasteur decided not to continue and try again next year. He went back to the Parisian boarding school to prepare for the test. He also attended classes at the Lycée Saint-Louis and lectures of Jean-Baptiste Dumas at the Sorbonne . In 1843, he passed the test with a high ranking and entered the École Normale Supérieure . In 1845 he received

9044-415: The first three years, Pasteur thought that the corpuscles were a symptom of the disease. In 1870, he concluded that the corpuscles were the cause of pébrine (it is now known that the cause is a microsporidian ). Pasteur also showed that the disease was hereditary. Pasteur developed a system to prevent pébrine: after the female moths laid their eggs, the moths were turned into a pulp. The pulp was examined with

9163-423: The first vaccine developed by Jenner, since the latter had never been obtained experimentally. Pasteur did not directly disclose how he prepared the vaccines used at Pouilly-le-Fort. Although his report indicated it as a "live vaccine", his laboratory notebooks show that he actually used potassium dichromate -killed vaccine, as developed by Chamberland, quite similar to Toussaint's method. Foreign Member of

9282-404: The flask, and no organisms grew in it. In another experiment, when he opened flasks containing boiled liquid, dust entered the flasks, causing organisms to grow in some of them. The number of flasks in which organisms grew was lower at higher altitudes, showing that air at high altitudes contained less dust and fewer organisms. Pasteur also used swan neck flasks containing a fermentable liquid. Air

9401-408: The four unvaccinated cows would perish or at least become very ill." However, all vaccinated sheep and goats survived, while unvaccinated ones had died or were dying before the viewers. His report to the French Academy of Sciences on 13 June concludes: [By] looking at everything from the scientific point of view, the development of a vaccination against anthrax constitutes significant progress beyond

9520-540: The good of the Royal Society of London for Improving Natural Knowledge, and to pursue the ends for which the same was founded; that we will carry out, as far as we are able, those actions requested of us in the name of the Council; and that we will observe the Statutes and Standing Orders of the said Society. Provided that, whensoever any of us shall signify to the President under our hands, that we desire to withdraw from

9639-472: The latter epithet also attributed to Antonie van Leeuwenhoek ). Pasteur was responsible for disproving the doctrine of spontaneous generation . Under the auspices of the French Academy of Sciences , his experiment demonstrated that in sterilized and sealed flasks, nothing ever developed; conversely, in sterilized but open flasks, microorganisms could grow. For this experiment, the academy awarded him

9758-419: The left-handed one was levorotatory. Pasteur determined that optical activity related to the shape of the crystals, and that an asymmetric internal arrangement of the molecules of the compound was responsible for twisting the light. The (2 R ,3 R )- and (2 S ,3 S )- tartrates were isometric, non-superposable mirror images of each other. This was the first time anyone had demonstrated molecular chirality , and also

9877-634: The medieval defenses restored and completed by Charles V in the sixteenth century with a belt provided with six bastioned battery towers  : the Notre-Dame tower, the bastioned tower of Chamars, the bastioned tower of the Marais, the bastioned tower of the Cordeliers (completed in 1691), the bastioned tower of Bregille and the bastioned tower of Rivotte. Fortifications prior to the French conquest are also numerous. The Tour de la Pelote, located on

9996-486: The most important experiments disproving the theory of spontaneous generation. Pasteur gave a series of five presentations of his findings before the French Academy of Sciences in 1881, which were published in 1882 as Mémoire Sur les corpuscules organisés qui existent dans l'atmosphère: Examen de la doctrine des générations spontanées ( Account of Organized Corpuscles Existing in the Atmosphere: Examining

10115-414: The name of one of Besançon's most prestigious brands of watches. Refusing to let their factory close, the workers set up a cooperative to run it. The action produced a lot of notoriety and sympathy for the workers but also resulted in branding Besançon as a city of the radical left. It also did nothing to help revive the watch industry; the cooperative went out of business a short while later. The city took

10234-491: The name permutated to become Besantio , Besontion , Bisanz in Middle High German , and gradually arrived at the modern French Besançon . The locals retain their ancient heritage referring to themselves as Bisontins (feminine: Bisontine ). It has been an archbishopric since the 4th century. In 843, the Treaty of Verdun divided up Charlemagne 's empire. Besançon became part of Lotharingia , under

10353-504: The neck of the oxbow that is the site of the original town. In their construction, the Spaniards followed Vauban's designs. In 1674, French troops recaptured the city, which the Treaty of Nijmegen (1678) then awarded to France. At this time the city became the administrative centre for the Franche-Comté, with its own Parlement of Besançon , which replaced Dole . As a result of control passing to France, Vauban returned to working on

10472-516: The new word pébrine , Pasteur made the mistake of believing that the two diseases were the same and even that most of the diseases of silkworms known up to that time were identical with each other and with pébrine. It was in letters of 30 April and 21 May 1867 to Dumas that he first made the distinction between pébrine and flacherie. He made another mistake: he began by denying the "parasitic" (microbial) nature of pébrine, which several scholars (notably Antoine Béchamp ) considered well established. Even

10591-615: The old town. Vauban 's imposing Citadelle blocks off the neck. The historic center presents an ensemble of classic stone buildings, some dating back to the Middle Ages and others to the Spanish Renaissance. During Antiquity, Vesontio was an important metropolis of Roman Gaul . It is adorned with monuments, some of which have survived, archaeological excavations carried out during construction sites often revealing new discoveries dating from this period. The most emblematic and best-preserved monument dating from this period

10710-421: The other in physics: (a) Chemistry Thesis: "Recherches sur la capacité de saturation de l'acide arsénieux. Etudes des arsénites de potasse, de soude et d'ammoniaque."; (b) Physics Thesis: "1. Études des phénomènes relatifs à la polarisation rotatoire des liquides. 2. Application de la polarisation rotatoire des liquides à la solution de diverses questions de chimie." After serving briefly as professor of physics at

10829-475: The population of the City of Besançon was 119,198. It is the 33rd most populous city of France. Grand Besançon Métropole covers 528.6 km (204.1 sq mi), 68 municipalities and has a population of 197,494. The metropolitan area covers 2,514.5 km (970.9 sq mi), 310 municipalities and has 283,127 inhabitants. Its population increased by 4.9% between 2008 and 2020. Until 2016, Besançon

10948-514: The post nominal letters HonFRS . Statute 12 is a legacy mechanism for electing members before official honorary membership existed in 1997. Fellows elected under statute 12 include David Attenborough (1983) and John Palmer, 4th Earl of Selborne (1991). The Council of the Royal Society can recommend members of the British royal family for election as Royal Fellow of the Royal Society . As of 2023 there are four royal fellows: Elizabeth II

11067-449: The process, to fight the "diseases" of wine, in 1865. The method became known as pasteurization , and was soon applied to beer and milk. Beverage contamination led Pasteur to the idea that micro-organisms infecting animals and humans cause disease. He proposed preventing the entry of micro-organisms into the human body, leading Joseph Lister to develop antiseptic methods in surgery. In 1866, Pasteur published Études sur le Vin , about

11186-552: The proposal is being made. There is no limit on the number of nominations made each year. In 2015, there were 654 candidates for election as Fellows and 106 candidates for Foreign Membership. The Council of the Royal Society oversees the selection process and appoints 10 subject area committees, known as Sectional Committees, to recommend the strongest candidates for election to the Fellowship. The final list of up to 52 Fellowship candidates and up to 10 Foreign Membership candidates

11305-476: The protection of the King of Spain. In 1598, Philip II gave the province to his daughter on her marriage to an Austrian archduke. It remained formally a portion of the Empire until its cession at the peace of Westphalia in 1648. Spain regained control of Franche-Comté and the city lost its status as a free city. Then in 1667, Louis XIV claimed the province as a consequence of his marriage to Marie-Thérèse of Spain in

11424-538: The regional archeology service and a zoo. It is the symbol of the city. Fort Griffon, whose name is that of the Italian architect Jean Griffoni who was commissioned to build a first fortification at this location in 1595, is a second citadel. It was Vauban who, at the end of the 17th century, had the current fort built. The city walls designed by Vauban includes all the fortifications of La Boucle historic district which were rebuilt from 1675 to 1695. Vauban in fact replaced

11543-511: The regional offices of the French National Institute for Statistics and Economic Studies (Insee) or the Centre régional des œuvres universitaires et scolaires (Crous). Mayor of the City of Besançon is Anne Vignot ( The Greens ). The city is known for its microtechnology and watch industries. It is host of the biannual Micronora trade fair, one of Europe's major events in the field of microtechnologies. The city has

11662-424: The results with chicken cholera, Pasteur eventually utilized the immunization method developed for chicken cholera to create a vaccine for anthrax , which affected cattle . In 1877, Pasteur had earlier directed his laboratory to culture the bacteria from the blood of infected animals, following thediscovery of the bacterium by Robert Koch. When animals were infected with the bacteria, anthrax occurred, proving that

11781-569: The river Doubs (a tributary of the Saône ); a mountain closes the fourth side. During the Bronze Age , c. 1500 BC, tribes of Gauls settled the oxbow. From the 1st century BC through the modern era, the town had a significant military importance because the Alps rise abruptly to its immediate south, presenting a significant natural barrier. The Arar ( Saône ) River formed part of the border between

11900-458: The skin of grapes was the natural source of yeasts, and that sterilized grapes and grape juice never fermented. He drew grape juice from under the skin with sterilized needles, and also covered grapes with sterilized cloth. Both experiments could not produce wine in sterilized containers. His findings and ideas were against the prevailing notion of spontaneous generation . He received a particularly stern criticism from Félix Archimède Pouchet , who

12019-423: The task of conducting the trial, were concerned about the unreliability of the attenuated vaccine, and therefore Chamberland secretly prepared an alternative vaccine using chemical inactivation. Without divulging their method of preparing the vaccine to anyone but Pasteur, Roux and Chamberland performed the public experiment on May at Pouilly-le-Fort. 58 sheep, 2 goats and 10 cattle were used, half of which were given

12138-519: The technique of treating milk and wine to stop bacterial contamination, a process now called pasteurization. Pasteur also made significant discoveries in chemistry, most notably on the molecular basis for the asymmetry of certain crystals and racemization . Early in his career, his investigation of sodium ammonium tartrate initiated the field of optical isomerism . This work had a profound effect on structural chemistry, with eventual implications for many areas including medicinal chemistry . He

12257-494: The term "attenuation" for this weakening of virulence as he presented before the academy, saying: We can diminish the microbe's virulence by changing the mode of culturing. This is the crucial point of my subject. I ask the Academy not to criticize, for the time being, the confidence of my proceedings that permit me to determine the microbe's attenuation, in order to save the independence of my studies and to better assure their progress... [In conclusion] I would like to point out to

12376-527: The topic by repeating and confirming works of Theodor Schwann , who demonstrated a decade earlier that yeast were alive. According to his son-in-law, René Vallery-Radot, in August 1857 Pasteur sent a paper about lactic acid fermentation to the Société des Sciences de Lille, but the paper was read three months later. A memoire was subsequently published on 30 November 1857. In the memoir, he developed his ideas stating that: "I intend to establish that, just as there

12495-402: The town has developed a reputation as one of France's leading centres of technology in all fields, including telecommunications and biotechnology. Besançon is the seat of the University of Franche-Comté . As of 2018 , there were approximately 24,000 students enrolled at the university, including around 3,000 foreign students. The Institut Supérieur d'Ingénieurs de Franche-Comté (ISIFC), part of

12614-454: The understanding of the causes and preventions of diseases , which laid down the foundations of hygiene, public health and much of modern medicine. Pasteur's works are credited with saving millions of lives through the developments of vaccines for rabies and anthrax . He is regarded as one of the founders of modern bacteriology and has been honored as the "father of bacteriology" and the "father of microbiology " (together with Robert Koch ;

12733-436: The vaccine on 5 and 17 May; while the other half was untreated. On 31 May, Roux and Chamberland next injected the animals with the fresh virulent culture of anthrax bacillus. The official result was observed and analyzed on 2 June in the presence of over 200 spectators, with Pasteur himself in attendance. The results were as Pasteur had bravely predicted: "I hypothesized that the six vaccinated cows would not become very ill, while

12852-451: The war of 1870–1871, the Fort des Montboucons built from 1877 to 1880 and the Fort des Justices built from 1870. A third Lunette d'Arçon was located on the site of Fort Chaudanne; only its tower was preserved during the construction of the fort in the first half of the 19th century. The Ruty barracks, formerly Saint-Paul barracks, are made up of four pavilions surrounding a courtyard serving as

12971-465: The world within its Centre for Applied Linguistics (CLA). The greenest city in France, it enjoys a quality of life recognized in Europe. Thanks to its rich historical and cultural heritage and its unique architecture, Besançon has been labeled a " Town of Art and History " since 1986. Its fortifications , designed by Vauban , have been listed as a UNESCO World Heritage Site since 2008. The city

13090-459: The world. As well as being famed as one of France's finest "villes d'art" (art cities), Besançon is the seat of one of France's older universities, of France's National School of Mechanics and Micromechanics , and one of the best known French language schools in France, the CLA. The most historic center of the town is characterised by the broad horse-shoe of the river Doubs, "la Boucle", which encircles

13209-410: Was allowed to enter the flask via a long curving tube that made dust particles stick to it. Nothing grew in the broths unless the flasks were tilted, making the liquid touch the contaminated walls of the neck. This showed that the living organisms that grew in such broths came from outside, on dust, rather than spontaneously generating within the liquid or from the action of pure air. These were some of

13328-491: Was built by Vauban from 1678 to 1771 and is the most visited site in Franche-Comté with more than 250,000 visitors each year. It extends over eleven hectares at the top of Mont Saint-Étienne at an altitude between 330 and 370 meters, thus overhanging the meander of the river Doubs which has an altitude between 240 and 250 meters. It brings together a museum of Resistance and Deportation, a museum of Franche-Comté traditions,

13447-453: Was caused by decomposition. Pasteur demonstrated that this theory was incorrect, and that yeast was responsible for fermentation to produce alcohol from sugar. He also demonstrated that, when a different microorganism contaminated the wine, lactic acid was produced, making the wine sour. In 1861, Pasteur observed that less sugar fermented per part of yeast when the yeast was exposed to air. The lower rate of fermentation aerobically became known as

13566-638: Was director of the Rouen Museum of Natural History . To settle the debate between the eminent scientists, the French Academy of Sciences offered the Alhumbert Prize carrying 2,500 francs to whoever could experimentally demonstrate for or against the doctrine. Pouchet stated that air everywhere could cause spontaneous generation of living organisms in liquids. In the late 1850s, he performed experiments and claimed that they were evidence of spontaneous generation. Francesco Redi and Lazzaro Spallanzani had provided some evidence against spontaneous generation in

13685-421: Was not a Royal Fellow, but provided her patronage to the society, as all reigning British monarchs have done since Charles II of England . Prince Philip, Duke of Edinburgh (1951) was elected under statute 12, not as a Royal Fellow. The election of new fellows is announced annually in May, after their nomination and a period of peer-reviewed selection. Each candidate for Fellowship or Foreign Membership

13804-512: Was not a great success. Upon hearing the news, Pasteur immediately wrote to the academy that he could not believe that dead vaccine would work and that Toussaint's claim "overturns all the ideas I had on viruses, vaccines, etc." Following Pasteur's criticism, Toussaint switched to carbolic acid (phenol) to kill anthrax bacilli and tested the vaccine on sheep in August 1880. Pasteur thought that this type of killed vaccine should not work because he believed that attenuated bacteria used up nutrients that

13923-420: Was that tartaric acid derived by chemical synthesis had no such effect, even though its chemical reactions were identical and its elemental composition was the same. Pasteur noticed that crystals of tartrates had small faces. Then he observed that, in racemic mixtures of tartrates, half of the crystals were right-handed and half were left-handed. In solution, the right-handed compound was dextrorotatory , and

14042-455: Was the capital of the Franche-Comté administrative région of France, a région including the four départements of Doubs, Haute-Saône , Jura and Territoire de Belfort . Franche-Comté was since merged with the neighbouring region of Burgundy , and the "préfecture" was transferred to the city of Dijon . However, Besançon remains the seat of the Bourgogne-Franche-Comté regional council and of various decentralised administrations such as

14161-545: Was the director of the Pasteur Institute , established in 1887, until his death, and his body was interred in a vault beneath the institute. Although Pasteur made groundbreaking experiments, his reputation became associated with various controversies. Historical reassessment of his notebook revealed that he practiced deception to overcome his rivals. Louis Pasteur was born on 27 December 1822, in Dole, Jura , France, to

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