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146-465: Leukemia ( also spelled leukaemia ; pronounced / l uː ˈ k iː m iː ə / loo- KEE -mee-ə ) is a group of blood cancers that usually begin in the bone marrow and produce high numbers of abnormal blood cells . These blood cells are not fully developed and are called blasts or leukemia cells . Symptoms may include bleeding and bruising , bone pain , fatigue , fever , and an increased risk of infections. These symptoms occur due to

292-415: A monoclonal antibody that attacks white blood cells, has been used in treatment with greater success than previous options. Some people who successfully respond to treatment also undergo stem cell transplantation to consolidate the response. Treatment for juvenile myelomonocytic leukemia can include splenectomy , chemotherapy , and bone marrow transplantation . The success of treatment depends on

438-488: A child has a serious illness. With respect to the effect of antipyretics on the risk of death in those with infection, studies have found mixed results, as of 2019. Fever is one of the most common medical signs . It is part of about 30% of healthcare visits by children, and occurs in up to 75% of adults who are seriously sick. About 5% of people who go to an emergency room have a fever. A number of types of fever were known as early as 460 BC to 370 BC when Hippocrates

584-691: A consonant followed by an unstressed -re (pronounced /ə(r)/ ). In modern American English, most of these words have the ending -er . The difference is most common for words ending in -bre or -tre : British spellings calibre , centre , fibre , goitre , litre , lustre , manoeuvre , meagre , metre (length) , mitre , nitre , ochre , reconnoitre , sabre , saltpetre , sepulchre , sombre , spectre , theatre (see exceptions ) and titre all have -er in American spelling. In Britain, both -re and -er spellings were common before Johnson's 1755 dictionary

730-475: A distinctive set of Canadian English spellings is viewed by many Canadians as one of the unique aspects of Canadian culture (especially when compared to the United States). In Australia, -or endings enjoyed some use throughout the 19th century and in the early 20th century. Like Canada, though, most major Australian newspapers have switched from " -or " endings to " -our " endings. The " -our " spelling

876-495: A emium , and a enigma . In others, it is kept in all varieties: for example, phoenix , and usually subpoena , but Phenix in Virginia . This is especially true of names: Aegean (the sea), Caesar , Oedipus , Phoebe , etc., although "caesarean section" may be spelled as "cesarean section". There is no reduction of Latin -ae plurals (e.g., larv ae ); nor where the digraph <ae>/<oe> does not result from

1022-466: A eon , an a emia , an a esthesia , c a ecum , c a esium , c o eliac , diarrh o ea , encyclop a edia , f a eces , f o etal , gyn a ecology , h a emoglobin , h a emophilia , leuk a emia , o esophagus , o estrogen , orthop a edic , pal a eontology , p a ediatric , p a edophile . Oenology is acceptable in American English but is deemed

1168-581: A feeling of cold or chills . This results in greater heat production and efforts to conserve heat. When the set point temperature returns to normal, a person feels hot, becomes flushed , and may begin to sweat . Rarely a fever may trigger a febrile seizure , with this being more common in young children. Fevers do not typically go higher than 41 to 42 °C (106 to 108 °F). A fever can be caused by many medical conditions ranging from non-serious to life-threatening . This includes viral , bacterial , and parasitic infections —such as influenza ,

1314-581: A fever recover without specific medical attention. Although it is unpleasant, fever rarely rises to a dangerous level even if untreated. Damage to the brain generally does not occur until temperatures reach 42.0 °C (107.6 °F), and it is rare for an untreated fever to exceed 40.6 °C (105.1 °F). Treating fever in people with sepsis does not affect outcomes. Small trials have shown no benefit of treating fevers of 38.5 °C (101.3 °F) or higher of critically ill patients in ICUs, and one trial

1460-653: A genetic abnormality called the Philadelphia translocation ; 95% of people with CML carry the Philadelphia mutation, although this is not exclusive to CML and can be observed in people with other types of leukemia. Whether or not non-ionizing radiation causes leukemia has been studied for several decades. The International Agency for Research on Cancer expert working group undertook a detailed review of all data on static and extremely low frequency electromagnetic energy, which occurs naturally and in association with

1606-455: A greater risk of leukemia. For example, people with Down syndrome have a significantly increased risk of developing forms of acute leukemia (especially acute myeloid leukemia ), and Fanconi anemia is a risk factor for developing acute myeloid leukemia. Mutation in SPRED1 gene has been associated with a predisposition to childhood leukemia. Inherited bone marrow failure syndromes represent

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1752-402: A kind of premature aging of the bone marrow. In people with these syndromes and in older adults, mutations associated with clonal hematopoiesis may arise as an adaptive response to a progressively deteriorating hematopoietic niche, i.e., a depleting pool of Hematopoietic stem cells . The mutated stem cells then acquire a self-renewal advantage. Chronic myelogenous leukemia is associated with

1898-463: A lack of blood platelets , which are important in the blood clotting process. This means people with leukemia may easily become bruised , bleed excessively, or develop pinprick bleeds ( petechiae ). White blood cells , which are involved in fighting pathogens , may be suppressed or dysfunctional. This could cause the person's immune system to be unable to fight off a simple infection or to start attacking other body cells. Because leukemia prevents

2044-632: A lack of normal blood cells . Diagnosis is typically made by blood tests or bone marrow biopsy . The exact cause of leukemia is unknown. A combination of genetic factors and environmental (non-inherited) factors are believed to play a role. Risk factors include smoking , ionizing radiation , petrochemicals (such as benzene ), prior chemotherapy, and Down syndrome . People with a family history of leukemia are also at higher risk. There are four main types of leukemia— acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML)—and

2190-532: A minor variant of enology , whereas although archeology and ameba exist in American English, the British versions amoeba and archaeology are more common. The chemical haem (named as a shortening of h a emoglobin ) is spelled heme in American English, to avoid confusion with hem . Canadian English mostly follows American English in this respect, although it is split on gynecology (e.g. Society of Obstetricians and Gynaecologists of Canada vs.

2336-569: A mistaken etymology. The etymologically correct original spelling fetus reflects the Latin original and is the standard spelling in medical journals worldwide; the Oxford English Dictionary notes that "In Latin manuscripts both fētus and foetus are used". The Ancient Greek diphthongs <αι> and <οι> were transliterated into Latin as <ae> and <oe>. The ligatures æ and œ were introduced when

2482-504: A more advanced, uncontrolled state, when the person cannot tolerate imatinib, or if the person wishes to attempt a permanent cure, then an allogeneic bone marrow transplantation may be performed. This procedure involves high-dose chemotherapy and radiation followed by infusion of bone marrow from a compatible donor. Approximately 30% of people die from this procedure. Decision to treat People with hairy cell leukemia who are symptom-free typically do not receive immediate treatment. Treatment

2628-512: A multi-drug chemotherapy regimen . Some are also treated with radiation therapy . In some cases, a bone marrow transplant is effective. Management of ALL is directed towards control of bone marrow and systemic (whole-body) disease. Additionally, treatment must prevent leukemic cells from spreading to other sites, particularly the central nervous system (CNS); periodic lumbar punctures are used for diagnostic purposes and to administer intrathecal prophylactic methotrexate. In general, ALL treatment

2774-512: A number of less common types. Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system , known as tumors of the hematopoietic and lymphoid tissues . Treatment may involve some combination of chemotherapy , radiation therapy , targeted therapy , and bone marrow transplant , with supportive and palliative care provided as needed. Certain types of leukemia may be managed with watchful waiting . The success of treatment depends on

2920-511: A phenomenon known as fever phobia, which is based in both caregiver's and parents' misconceptions about fever in children. Among them, many parents incorrectly believe that fever is a disease rather than a medical sign , that even low fevers are harmful, and that any temperature even briefly or slightly above the oversimplified "normal" number marked on a thermometer is a clinically significant fever. They are also afraid of harmless side effects like febrile seizures and dramatically overestimate

3066-531: A positive correlation between exposure to formaldehyde and the development of leukemia, particularly myeloid leukemia . The different leukemias likely have different causes. Leukemia, like other cancers, results from mutations in the DNA . Certain mutations can trigger leukemia by activating oncogenes or deactivating tumor suppressor genes , and thereby disrupting the regulation of cell death, differentiation or division. These mutations may occur spontaneously or as

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3212-547: A previous study showing the EP3 subtype is what mediates the fever response. Hence, the hypothalamus can be seen as working like a thermostat . When the set point is raised, the body increases its temperature through both active generation of heat and retention of heat. Peripheral vasoconstriction both reduces heat loss through the skin and causes the person to feel cold. Norepinephrine increases thermogenesis in brown adipose tissue , and muscle contraction through shivering raises

3358-399: A pyrogen, mediated by interleukin 1 (IL-1) release. These cytokine factors are released into general circulation, where they migrate to the brain's circumventricular organs where they are more easily absorbed than in areas protected by the blood–brain barrier . The cytokines then bind to endothelial receptors on vessel walls to receptors on microglial cells , resulting in activation of

3504-420: A reaction to an incompatible blood product. Fever is thought to contribute to host defense, as the reproduction of pathogens with strict temperature requirements can be hindered, and the rates of some important immunological reactions are increased by temperature. Fever has been described in teaching texts as assisting the healing process in various ways, including: A fever response to an infectious disease

3650-413: A result of brain stem pressure. All symptoms associated with leukemia can be attributed to other diseases. Consequently, leukemia is always diagnosed through medical tests . The word leukemia , which means 'white blood', is derived from the characteristic high white blood cell count that presents in most affected people before treatment. The high number of white blood cells is apparent when a blood sample

3796-460: A result of exposure to radiation or carcinogenic substances. Among adults, the known causes are natural and artificial ionizing radiation and petrochemicals, notably benzene and alkylating chemotherapy agents for previous malignancies. Use of tobacco is associated with a small increase in the risk of developing acute myeloid leukemia in adults. Cohort and case-control studies have linked exposure to some petrochemicals and hair dyes to

3942-412: A simple injection under the skin, or six months of pentostatin , given every four weeks by intravenous infusion. In most cases, one round of treatment will produce a prolonged remission. Other treatments include rituximab infusion or self-injection with Interferon-alpha . In limited cases, the person may benefit from splenectomy (removal of the spleen ). These treatments are not typically given as

4088-667: A suffix for agentive ( reader , user , winner ) and comparative ( louder , nicer ) forms. One outcome is the British distinction of meter for a measuring instrument from metre for the unit of length. However, while " poetic metre " is often spelled as -re , pentameter , hexameter , etc. are always -er . Many other words have -er in British English. These include Germanic words, such as anger , mother , timber and water , and such Romance-derived words as danger , quarter and river . The ending -cre , as in acre , lucre , massacre , and mediocre ,

4234-467: A total of four main categories. Within each of these main categories, there are typically several subcategories. Finally, some rarer types are usually considered to be outside of this classification scheme. The most common symptoms in children are easy bruising , pale skin , fever , and an enlarged spleen or liver . Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells, results in

4380-481: Is viewed under a microscope , with the extra white blood cells frequently being immature or dysfunctional. The excessive number of cells can also interfere with the level of other cells, causing further harmful imbalance in the blood count. Some people diagnosed with leukemia do not have high white blood cell counts visible during a regular blood count. This less-common condition is called aleukemia . The bone marrow still contains cancerous white blood cells that disrupt

4526-432: Is - /s/ for the noun and - /z/ for the verb). For licence / license or practice / practise , British English also keeps the noun–verb distinction graphically (although phonetically the two words in each pair are homophones with - /s/ pronunciation). On the other hand, American English uses license and practice for both nouns and verbs (with - /s/ pronunciation in both cases too). American English has kept

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4672-463: Is 35.5–37.5 °C (95.9–99.5 °F) among men and 35.7–37.5 °C (96.3–99.5 °F) among women. Normal body temperatures vary depending on many factors, including age, sex, time of day, ambient temperature, activity level, and more. Normal daily temperature variation has been described as 0.5 °C (0.9 °F). A raised temperature is not always a fever. For example, the temperature rises in healthy people when they exercise, but this

4818-450: Is a symptom of organism's anti-infection defense mechanism that appears with body temperature exceeding the normal range due to an increase in the body's temperature set point in the hypothalamus . There is no single agreed-upon upper limit for normal temperature: sources use values ranging between 37.2 and 38.3 °C (99.0 and 100.9 °F) in humans. The increase in set point triggers increased muscle contractions and causes

4964-465: Is activation of the arachidonic acid pathway . PGE2 release comes from the arachidonic acid pathway. This pathway (as it relates to fever), is mediated by the enzymes phospholipase A2 (PLA2), cyclooxygenase-2 (COX-2), and prostaglandin E2 synthase . These enzymes ultimately mediate the synthesis and release of PGE2. PGE2 is the ultimate mediator of the febrile response. The setpoint temperature of

5110-534: Is acute or chronic, the specific abnormal white blood cell type, the presence and severity of anemia or thrombocytopenia , the degree of tissue abnormality, the presence of metastasis and lymph node and bone marrow infiltration, the availability of therapies and the skills of the health care team. Treatment outcomes may be better when people are treated at larger centers with greater experience. In 2010, globally, approximately 281,500 people died of leukemia. In 2000, approximately 256,000 children and adults around

5256-512: Is also superior to aspirin in children with fevers. Additionally, aspirin is not recommended in children and young adults (those under the age of 16 or 19 depending on the country) due to the risk of Reye's syndrome . Using both paracetamol and ibuprofen at the same time or alternating between the two is more effective at decreasing fever than using only paracetamol or ibuprofen. It is not clear if it increases child comfort. Response or nonresponse to medications does not predict whether or not

5402-546: Is an intracranial hemorrhage . Other causes in emergency room settings include sepsis , Kawasaki syndrome , neuroleptic malignant syndrome , drug overdose , serotonin syndrome , and thyroid storm . Fever is a common symptom of many medical conditions: Adult and pediatric manifestations for the same disease may differ; for instance, in COVID-19 , one metastudy describes 92.8% of adults versus 43.9% of children presenting with fever. In addition, fever can result from

5548-408: Is associated with reduced mortality. Temperature is regulated in the hypothalamus . The trigger of a fever, called a pyrogen, results in the release of prostaglandin E2 (PGE2). PGE2 in turn acts on the hypothalamus, which creates a systemic response in the body, causing heat-generating effects to match a new higher temperature set point. There are four receptors in which PGE2 can bind (EP1-4), with

5694-433: Is demonstrated by family histories and twin studies . The affected people may have a single gene or multiple genes in common. In some cases, families tend to develop the same kinds of leukemia as other members; in other families, affected people may develop different forms of leukemia or related blood cancers . In addition to these genetic issues, people with chromosomal abnormalities or certain other genetic conditions have

5840-672: Is directed towards suppressing the disease for many years, rather than curing it. The primary chemotherapeutic plan is combination chemotherapy with chlorambucil or cyclophosphamide , plus a corticosteroid such as prednisone or prednisolone . The use of a corticosteroid has the additional benefit of suppressing some related autoimmune diseases, such as immunohemolytic anemia or immune-mediated thrombocytopenia . In resistant cases, single-agent treatments with nucleoside drugs such as fludarabine , pentostatin , or cladribine may be successful. Younger and healthier people may choose allogeneic or autologous bone marrow transplantation in

5986-433: Is divided into several phases: Hematologists base CLL treatment on both the stage and symptoms of the individual person. A large group of people with CLL have low-grade disease, which does not benefit from treatment. Individuals with CLL-related complications or more advanced disease often benefit from treatment. In general, the indications for treatment are: Most CLL cases are incurable by present treatments, so treatment

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6132-399: Is dropped for other derivations, for example, central , fibrous , spectral . However, the existence of related words without e before the r is not proof for the existence of an -re British spelling: for example, entry and entrance come from enter , which has not been spelled entre for centuries. The difference relates only to root words; -er rather than -re is universal as

6278-446: Is generally agreed to be present if the elevated temperature is caused by a raised set point and: In adults, the normal range of oral temperatures in healthy individuals is 35.7–37.7 °C (96.3–99.9 °F) among men and 33.2–38.1 °C (91.8–100.6 °F) among women, while when taken rectally it is 36.7–37.5 °C (98.1–99.5 °F) among men and 36.8–37.1 °C (98.2–98.8 °F) among women, and for ear measurement it

6424-443: Is generally considered necessary when the person shows signs and symptoms such as low blood cell counts (e.g., infection-fighting neutrophil count below 1.0 K/μL), frequent infections, unexplained bruises, anemia, or fatigue that is significant enough to disrupt the person's everyday life. Typical treatment approach People who need treatment usually receive either one week of cladribine , given daily by intravenous infusion or

6570-461: Is generally not required. Treatment of associated pain and inflammation, however, may be useful and help a person rest. Medications such as ibuprofen or paracetamol (acetaminophen) may help with this as well as lower temperature. Children younger than three months require medical attention, as might people with serious medical problems such as a compromised immune system or people with other symptoms. Hyperthermia requires treatment. Fever

6716-502: Is generally preferred over oe and often over ae , but oe and ae are sometimes found in academic and scientific writing as well as government publications (for example, the fee schedule of the Ontario Health Insurance Plan ) and some words such as palaeontology or aeon . In Australia, it can go either way, depending on the word: for instance, medieval is spelled with the e rather than ae , following

6862-453: Is generally regarded as protective, whereas fever in non-infections may be maladaptive. Studies have not been consistent on whether treating fever generally worsens or improves mortality risk. Benefits or harms may depend on the type of infection, health status of the patient and other factors. Studies using warm-blooded vertebrates suggest that they recover more rapidly from infections or critical illness due to fever. In sepsis , fever

7008-601: Is known as the Pacific Parlour car, not Pacific Parlor . Proper names such as Pearl Harbor or Sydney Harbour are usually spelled according to their native-variety spelling vocabulary. The name of the herb savory is spelled thus everywhere, although the related adjective savo(u)ry , like savo(u)r , has a u in the UK. Honor (the name) and arbor (the tool) have -or in Britain, as mentioned above, as does

7154-523: Is more commonly seen in people receiving immune-suppressing chemotherapy than in apparently healthy people. Hyperpyrexia is an extreme elevation of body temperature which, depending upon the source, is classified as a core body temperature greater than or equal to 40 or 41 °C (104 or 106 °F); the range of hyperpyrexia includes cases considered severe (≥ 40 °C) and extreme (≥ 42 °C). It differs from hyperthermia in that one's thermoregulatory system's set point for body temperature

7300-411: Is not considered a fever, as the set point is normal. On the other hand, a "normal" temperature may be a fever, if it is unusually high for that person; for example, medically frail elderly people have a decreased ability to generate body heat, so a "normal" temperature of 37.3 °C (99.1 °F) may represent a clinically significant fever. Hyperthermia is an elevation of body temperature over

7446-598: Is often established by identifying possible causes. Various patterns of measured patient temperatures have been observed, some of which may be indicative of a particular medical diagnosis : Among the types of intermittent fever are ones specific to cases of malaria caused by different pathogens. These are: In addition, there is disagreement regarding whether a specific fever pattern is associated with Hodgkin's lymphoma —the Pel–Ebstein fever , with patients argued to present high temperature for one week, followed by low for

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7592-432: Is one of the most common medical signs . It is part of about 30% of healthcare visits by children and occurs in up to 75% of adults who are seriously sick. While fever evolved as a defense mechanism, treating a fever does not appear to improve or worsen outcomes. Fever is often viewed with greater concern by parents and healthcare professionals than is usually deserved, a phenomenon known as "fever phobia." A fever

7738-404: Is set above normal, then heat is generated to achieve it. In contrast, hyperthermia involves body temperature rising above its set point due to outside factors. The high temperatures of hyperpyrexia are considered medical emergencies , as they may indicate a serious underlying condition or lead to severe morbidity (including permanent brain damage ), or to death. A common cause of hyperpyrexia

7884-613: Is sometimes used. The ratio between -ise and -ize stood at 3:2 in the British National Corpus up to 2002. The spelling -ise is more commonly used in UK mass media and newspapers, including The Times (which switched conventions in 1992), The Daily Telegraph , The Economist and the BBC . The Government of the United Kingdom additionally uses -ise , stating "do not use Americanisms" justifying that

8030-714: Is standard worldwide and complection is rare. However, the adjective complected (as in "dark-complected"), although sometimes proscribed, is on equal ground in the U.S. with complexioned. It is not used in this way in the UK, although there exists a rare alternative meaning of complicated . In some cases, words with "old-fashioned" spellings are retained widely in the U.S. for historical reasons (cf. connexionalism ). Many words, especially medical words, that are written with ae/æ or oe/œ in British English are written with just an e in American English. The sounds in question are /iː/ or /ɛ/ (or, unstressed, /i/ , /ɪ/ or /ə/ ). Examples (with non-American letter in bold ):

8176-439: Is still questionable whether phototherapy is genuinely the cause of cancer or simply a result of the same underlying factors that gave rise to cancer. Large doses of Sr-90 (called a bone seeking radioisotope) from nuclear reactor accidents, increases the risk of bone cancer and leukemia in animals and is presumed to do so in people. Some people have a genetic predisposition towards developing leukemia. This predisposition

8322-607: Is taught in schools nationwide as part of the Australian curriculum. The most notable countrywide use of the -or ending is for one of the country's major political parties, the Australian Labor Party , which was originally called "the Australian Labour Party" (name adopted in 1908), but was frequently referred to as both "Labour" and "Labor". The "Labor" was adopted from 1912 onward due to

8468-549: Is the usual form of the male given name, as a surname both the spellings Peter and Petre (the latter notably borne by a British lord ) are found. For British accoutre , the American practice varies: the Merriam-Webster Dictionary prefers the -re spelling, but The American Heritage Dictionary of the English Language prefers the -er spelling. More recent French loanwords keep

8614-530: Is uncommon. Despite the use of these methods to diagnose whether or not a person has leukemia, many people have not been diagnosed because many of the symptoms are vague, non-specific , and can refer to other diseases. For this reason, the American Cancer Society estimates that at least one-fifth of the people with leukemia have not yet been diagnosed. Most forms of leukemia are treated with pharmaceutical medication , typically combined into

8760-484: Is used in both British and American English to show that the c is pronounced /k/ rather than /s/ . The spellings euchre and ogre are also the same in both British and American English. Fire and its associated adjective fiery are the same in both British and American English, although the noun was spelled fier in Old and Middle English. Theater is the prevailing American spelling used to refer to both

8906-567: Is usually accompanied by sickness behavior , which consists of lethargy , depression , loss of appetite , sleepiness , hyperalgesia , dehydration , and the inability to concentrate. Sleeping with a fever can often cause intense or confusing nightmares , commonly called "fever dreams". Mild to severe delirium (which can also cause hallucinations ) may also present itself during high fevers. A range for normal temperatures has been found. Central temperatures, such as rectal temperatures, are more accurate than peripheral temperatures. Fever

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9052-591: The -meter suffix (from Ancient Greek - μέτρον métron , via French -mètre ) normally had the -re spelling from earliest use in English but were superseded by -er . Examples include thermometer and barometer . The e preceding the r is kept in American-inflected forms of nouns and verbs, for example, fibers , reconnoitered , centering , which are fibres , reconnoitred , and centring respectively in British English. According to

9198-560: The -ise form as an alternative. Publications by Oxford University Press (OUP)—such as Henry Watson Fowler 's A Dictionary of Modern English Usage , Hart's Rules , and The Oxford Guide to English Usage —also recommend -ize . However, Robert Allan's Pocket Fowler's Modern English Usage considers either spelling to be acceptable anywhere but the U.S. American spelling avoids -ise endings in words like organize , realize and recognize . British spelling mostly uses -ise ( organise , realise , recognise ), though -ize

9344-687: The -ise form is preferred in Australian English at a ratio of about 3:1 according to the Macquarie Dictionary . In Canada, the -ize ending is more common, although the Ontario Public School Spelling Book spelled most words in the -ize form, but allowed for duality with a page insert as late as the 1970s, noting that, although the -ize spelling was in fact the convention used in the OED ,

9490-439: The -ise variation, once more common amongst older Canadians, is employed less and less often in favour of the -ize spelling. (The alternate convention offered as a matter of choice may have been due to the fact that although there were an increasing number of American- and British-based dictionaries with Canadian Editions by the late 1970s, these were largely only supplemental in terms of vocabulary with subsequent definitions. It

9636-450: The -re spelling in American English. These are not exceptions when a French-style pronunciation is used ( /rə/ rather than /ə(r)/ ), as with double entendre , genre and oeuvre . However, the unstressed /ə(r)/ pronunciation of an -er ending is used more (or less) often with some words, including cadre , macabre , maître d' , Notre Dame , piastre , and timbre . The -re endings are mostly standard throughout

9782-495: The Canadian Medical Association 's Canadian specialty profile of Obstetrics/gynecology ). Pediatrician is preferred roughly 10 to 1 over paediatrician , while foetal and oestrogen are similarly uncommon. Words that can be spelled either way in American English include a esthetics and arch a eology (which usually prevail over esthetics and archeology ), as well as pal a estra , for which

9928-548: The OED , centring is a "word ... of 3 syllables (in careful pronunciation)" (i.e., /ˈsɛntərɪŋ/ ), yet there is no vowel in the spelling corresponding to the second syllable ( /ə/ ). The OED third edition (revised entry of June 2016) allows either two or three syllables. On the Oxford Dictionaries Online website, the three-syllable version is listed only as the American pronunciation of centering . The e

10074-689: The Organisation for Economic Co-operation and Development ). The European Union 's style guides require the usage of - ise . Proofreaders at the EU's Publications Office ensure consistent spelling in official publications such as the Official Journal of the European Union (where legislation and other official documents are published), but the -ize spelling may be found in other documents. Fever Fever or pyrexia in humans

10220-557: The Simplified Spelling Board in the early 20th century, but most were not adopted. In Britain, the influence of those who preferred the Norman (or Anglo-French ) spellings of words proved to be decisive. Later spelling adjustments in the United Kingdom had little effect on today's American spellings and vice versa. For the most part, the spelling systems of most Commonwealth countries and Ireland closely resemble

10366-538: The arachidonic acid pathway . Of these, IL-1β, TNF, and IL-6 are able to raise the temperature setpoint of an organism and cause fever. These proteins produce a cyclooxygenase which induces the hypothalamic production of PGE2 which then stimulates the release of neurotransmitters such as cyclic adenosine monophosphate and increases body temperature. Exogenous pyrogens are external to the body and are of microbial origin. In general, these pyrogens, including bacterial cell wall products, may act on Toll-like receptors in

10512-431: The cancer is unlikely to return . In 2015, leukemia was present in 2.3 million people worldwide and caused 353,500 deaths. In 2012, it had newly developed in 352,000 people. It is the most common type of cancer in children, with three-quarters of leukemia cases in children being the acute lymphoblastic type. However, over 90% of all leukemias are diagnosed in adults, CLL and AML being most common. It occurs more commonly in

10658-491: The common cold , meningitis , urinary tract infections , appendicitis , Lassa fever , COVID-19 , and malaria . Non-infectious causes include vasculitis , deep vein thrombosis , connective tissue disease , side effects of medication or vaccination, and cancer . It differs from hyperthermia , in that hyperthermia is an increase in body temperature over the temperature set point, due to either too much heat production or not enough heat loss . Treatment to reduce fever

10804-436: The developed world . Clinically and pathologically, leukemia is subdivided into a variety of large groups. The first division is between its acute and chronic forms: Additionally, the diseases are subdivided according to which kind of blood cell is affected. This divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias : Combining these two classifications provides

10950-419: The metabolic rate . If these measures are insufficient to make the blood temperature in the brain match the new set point in the hypothalamus, the brain orchestrates heat effector mechanisms via the autonomic nervous system or primary motor center for shivering. These may be: When the hypothalamic set point moves back to baseline—either spontaneously or via medication—normal functions such as sweating, and

11096-520: The sympathetic output system, which evokes non-shivering thermogenesis to produce body heat and skin vasoconstriction to decrease heat loss from the body surface. It is presumed that the innervation from the POA to the PVN mediates the neuroendocrine effects of fever through the pathway involving pituitary gland and various endocrine organs . Fever does not necessarily need to be treated, and most people with

11242-543: The theatre spelling. (The word "theater" in American English is a place where both stage performances and screenings of films take place, but in British English a "theatre" is where stage performances take place but not film screenings – these take place in a cinema, or "picture theatre" in Australia.) In the United States, the spelling theatre is sometimes used when referring to the art form of theatre, while

11388-519: The u has since been dropped: ambassadour , emperour , errour , governour , horrour , inferiour , mirrour , perturbatour , superiour , tenour , terrour , tremour . Johnson, unlike Webster, was not an advocate of spelling reform, but chose the spelling best derived, as he saw it, from among the variations in his sources. He preferred French over Latin spellings because, as he put it, "the French generally supplied us". English speakers who moved to

11534-435: The u : In American usage, derivatives and inflected forms are built by simply adding the suffix in all cases (for example, favorite , savory etc.) since the u is absent to begin with. American usage, in most cases, keeps the u in the word glamour , which comes from Scots , not Latin or French. Glamor is sometimes used in imitation of the spelling reform of other -our words to -or . Nevertheless,

11680-652: The ‑our/or group do not have a Latin counterpart that ends in ‑or ; for example, armo(u)r , behavio(u)r , harbo(u)r , neighbo(u)r ; also arbo(u)r , meaning "shelter", though senses "tree" and "tool" are always arbor , a false cognate of the other word. The word arbor would be more accurately spelled arber or arbre in the US and the UK, respectively, the latter of which is the French word for "tree". Some 16th- and early 17th-century British scholars indeed insisted that ‑or be used for words from Latin (e.g., color ) and ‑our for French loans; however, in many cases,

11826-408: The 1755 publication of Samuel Johnson 's A Dictionary of the English Language , and an "American standard" started following the work of Noah Webster and, in particular, his An American Dictionary of the English Language , first published in 1828. Webster's efforts at spelling reform were effective in his native country, resulting in certain well-known patterns of spelling differences between

11972-441: The 17th and 18th centuries, whereas there are thousands of examples of their -our counterparts. One notable exception is honor . Honor and honour were equally frequent in Britain until the 17th century; honor only exists in the UK now as the spelling of Honor Oak , a district of London, and of the occasional given name Honor . In derivatives and inflected forms of the -our/or words, British usage depends on

12118-615: The 1970s, but had by then been overtaken by connection in regular usage (for example, in more popular newspapers). Connexion (and its derivatives connexional and connexionalism ) is still in use by the Methodist Church of Great Britain to refer to the whole church as opposed to its constituent districts, circuits and local churches, whereas the US-majority United Methodist Church uses Connection . Complexion (which comes from complex )

12264-743: The American National Theatre was referred to by The New York Times as the "American National Theater ", but the organization uses "re" in the spelling of its name. The John F. Kennedy Center for the Performing Arts in Washington, D.C. has the more common American spelling theater in its references to the Eisenhower Theater, part of the Kennedy Center. Some cinemas outside New York also use

12410-480: The American and British varieties of English. However, English-language spelling reform has rarely been adopted otherwise. As a result, modern English orthography varies only minimally between countries and is far from phonemic in any country. In the early 18th century, English spelling was inconsistent. These differences became noticeable after the publication of influential dictionaries . Today's British English spellings mostly follow Johnson's A Dictionary of

12556-413: The American usage along with numerous other words such as eon or fetus , while other words such as oestrogen or paediatrician are spelled the British way. The Macquarie Dictionary also notes a growing tendency towards replacing ae and oe with e worldwide and with the exception of manoeuvre, all British or American spellings are acceptable variants. Elsewhere, the British usage prevails, but

12702-587: The Anglo-French spelling for defense and offense , which are defence and offence in British English. Likewise, there are the American pretense and British pretence ; but derivatives such as defensive , offensive , and pretension are always thus spelled in both systems. Australian and Canadian usages generally follow British usage. The spelling connexion is now rare in everyday British usage, its use lessening as knowledge of Latin attenuates, and it has almost never been used in

12848-440: The British system. In Canada, the spelling system can be said to follow both British and American forms, and Canadians are somewhat more tolerant of foreign spellings when compared with other English-speaking nationalities. Australian English mostly follows British spelling norms but has strayed slightly, with some American spellings incorporated as standard. New Zealand English is almost identical to British spelling, except in

12994-668: The British usage of -our . This coincided with a renewed interest in Canadian English, and the release of the updated Gage Canadian Dictionary in 1997 and the first Canadian Oxford Dictionary in 1998. Historically, most libraries and educational institutions in Canada have supported the use of the Oxford English Dictionary rather than the American Webster's Dictionary . Today, the use of

13140-471: The Commonwealth. The -er spellings are recognized as minor variants in Canada, partly due to United States influence. They are sometimes used in proper names (such as Toronto's controversially named Centerpoint Mall ). For advice / advise and device / devise , American English and British English both keep the noun–verb distinction both graphically and phonetically (where the pronunciation

13286-521: The English Language (1755), while many American English spellings follow Webster's An American Dictionary of the English Language ("ADEL", "Webster's Dictionary", 1828). Webster was a proponent of English spelling reform for reasons both philological and nationalistic. In A Companion to the American Revolution (2008), John Algeo notes: "it is often assumed that characteristically American spellings were invented by Noah Webster. He

13432-488: The Greek-style ligature as, for example, in maelstrom or toe ; the same is true for the British form aeroplane (compare other aero- words such as aerosol ) . The now chiefly North American airplane is not a respelling but a recoining, modelled after airship and aircraft . The word airplane dates from 1907, at which time the prefix aero- was trisyllabic, often written aëro- . In Canada, e

13578-518: The US: the more common connection has become the standard worldwide. According to the Oxford English Dictionary , the older spelling is more etymologically conservative, since the original Latin word had -xio- . The American usage comes from Webster , who abandoned -xion and preferred -ction . Connexion was still the house style of The Times of London until the 1980s and was still used by Post Office Telecommunications for its telephone services in

13724-497: The United States took these preferences with them. In the early 20th century, H. L. Mencken notes that " honor appears in the 1776 Declaration of Independence , but it seems to have been put there rather by accident than by design". In Jefferson 's original draft it is spelled "honour". In Britain, examples of behavior , color , flavor , harbor , and neighbor rarely appear in Old Bailey court records from

13870-423: The United States use Centre in their names. Examples include the villages of Newton Centre and Rockville Centre , the city of Centreville , Centre County and Centre College . Sometimes, these places were named before spelling changes but more often the spelling serves as an affectation. Proper names are usually spelled according to their native-variety spelling vocabulary; so, for instance, although Peter

14016-617: The adjective glamorous often drops the first "u". Saviour is a somewhat common variant of savior in the US. The British spelling is very common for honour (and favour ) in the formal language of wedding invitations in the US. The name of the Space Shuttle Endeavour has a u in it because the spacecraft was named after British Captain James Cook 's ship, HMS Endeavour . The (former) special car on Amtrak 's Coast Starlight train

14162-511: The age of fifteen. An older term, febricula (a diminutive form of the Latin word for fever), was once used to refer to a low-grade fever lasting only a few days. This term fell out of use in the early 20th century, and the symptoms it referred to are now thought to have been caused mainly by various minor viral respiratory infections . Fever is often viewed with greater concern by parents and healthcare professionals than might be deserved,

14308-617: The body or direct submersion in ice water ). In general, people are advised to keep adequately hydrated. Whether increased fluid intake improves symptoms or shortens respiratory illnesses such as the common cold is not known. Medications that lower fevers are called antipyretics . The antipyretic ibuprofen is effective in reducing fevers in children. It is more effective than acetaminophen (paracetamol) in children. Ibuprofen and acetaminophen may be safely used together in children with fevers. The efficacy of acetaminophen by itself in children with fevers has been questioned. Ibuprofen

14454-486: The body will remain elevated until PGE2 is no longer present. PGE2 acts on neurons in the preoptic area (POA) through the prostaglandin E receptor 3 (EP3). EP3-expressing neurons in the POA innervate the dorsomedial hypothalamus (DMH), the rostral raphe pallidus nucleus in the medulla oblongata (rRPa), and the paraventricular nucleus (PVN) of the hypothalamus. Fever signals sent to the DMH and rRPa lead to stimulation of

14600-940: The body. The "pyrogenicity" of given pyrogens varies: in extreme cases, bacterial pyrogens can act as superantigens and cause rapid and dangerous fevers. Endogenous pyrogens are cytokines released from monocytes (which are part of the immune system ). In general, they stimulate chemical responses, often in the presence of an antigen , leading to a fever. Whilst they can be a product of external factors like exogenous pyrogens, they can also be induced by internal factors like damage associated molecular patterns such as cases like rheumatoid arthritis or lupus. Major endogenous pyrogens are interleukin 1 (α and β) and interleukin 6 (IL-6). Minor endogenous pyrogens include interleukin-8 , tumor necrosis factor-β , macrophage inflammatory protein -α and macrophage inflammatory protein-β as well as interferon-α , interferon-β , and interferon-γ . Tumor necrosis factor-α (TNF) also acts as

14746-518: The building itself, as noted above, generally is spelled theater . For example, the University of Wisconsin–Madison has a "Department of Theatre and Drama", which offers courses that lead to the "Bachelor of Arts in Theatre ", and whose professed aim is "to prepare our graduate students for successful 21st Century careers in the theatre both as practitioners and scholars". Some placenames in

14892-452: The child's sleep to give the child more medicine. Fever is an important metric for the diagnosis of disease in domestic animals . The body temperature of animals, which is taken rectally, is different from one species to another. For example, a horse is said to have a fever above 101 °F ( 38.3 °C ). In species that allow the body to have a wide range of "normal" temperatures, such as camels , whose body temperature varies as

15038-456: The choice to spell such words in the -ise form was a matter of personal preference ; however, a pupil having made the decision, one way or the other, thereafter ought to write uniformly not only for a given word, but to apply that same uniformity consistently for all words where the option is found. Just as with -yze spellings, however, in Canada the ize form remains the preferred or more common spelling, though both can still be found, yet

15184-442: The circumstances surrounding it and its response to anti-pyretic medications. In infants, the autonomic nervous system may also activate brown adipose tissue to produce heat (non-shivering thermogenesis). Increased heart rate and vasoconstriction contribute to increased blood pressure in fever. A pyrogen is a substance that induces fever. In the presence of an infectious agent, such as bacteria, viruses, viroids, etc .,

15330-426: The close historic, economic, and cultural relationship with the United States, -or endings are also sometimes used. Throughout the late 19th and early to mid-20th century, most Canadian newspapers chose to use the American usage of -or endings, originally to save time and money in the era of manual movable type . However, in the 1990s, the majority of Canadian newspapers officially updated their spelling policies to

15476-412: The degree of liver and kidney damage or the effects of chemotherapy on the person. When concerns arise about other damages due to leukemia, doctors may use an X-ray , MRI , or ultrasound . These can potentially show leukemia's effects on such body parts as bones (X-ray), the brain (MRI), or the kidneys, spleen, and liver (ultrasound). CT scans can be used to check lymph nodes in the chest, though this

15622-404: The development of some forms of leukemia. Diet has very limited or no effect, although eating more vegetables may confer a small protective benefit. Viruses have also been linked to some forms of leukemia. For example, human T-lymphotropic virus (HTLV-1) causes adult T-cell leukemia . A few cases of maternal-fetal transmission (a baby acquires leukemia because its mother had leukemia during

15768-403: The dramatic arts and buildings where stage performances and screenings of films take place (i.e., " movie theaters "); for example, a national newspaper such as The New York Times would use theater in its entertainment section. However, the spelling theatre appears in the names of many New York City theatres on Broadway (cf. Broadway theatre) and elsewhere in the United States. In 2003,

15914-715: The ending became ‑our to match the later Old French spelling. The ‑our ending was used not only in new English borrowings, but was also applied to the earlier borrowings that had used ‑or . However, ‑or was still sometimes found. The first three folios of Shakespeare 's plays used both spellings before they were standardised to ‑our in the Fourth Folio of 1685. After the Renaissance , new borrowings from Latin were taken up with their original ‑or ending, and many words once ending in ‑our (for example, chancellour and governour ) reverted to ‑or . A few words of

16060-531: The environmental temperature varies, the body temperature which constitutes a febrile state differs depending on the environmental temperature. Fever can also be behaviorally induced by invertebrates that do not have immune-system based fever. For instance, some species of grasshopper will thermoregulate to achieve body temperatures that are 2–5 °C higher than normal in order to inhibit the growth of fungal pathogens such as Beauveria bassiana and Metarhizium acridum . Honeybee colonies are also able to induce

16206-406: The etymology was not clear, and therefore some scholars advocated ‑or only and others ‑our only. Webster's 1828 dictionary had only -or and is given much of the credit for the adoption of this form in the United States. By contrast, Johnson's 1755 (pre-U.S. independence and establishment) dictionary used -our for all words still so spelled in Britain (like colour ), but also for words where

16352-455: The evidence on both sides of the argument appears to be mostly equivocal. Limited evidence supports sponging or bathing feverish children with tepid water. The use of a fan or air conditioning may somewhat reduce the temperature and increase comfort. If the temperature reaches the extremely high level of hyperpyrexia , aggressive cooling is required (generally produced mechanically via conduction by applying numerous ice packs across most of

16498-857: The first treatment because their success rates are lower than cladribine or pentostatin. Most people with T-cell prolymphocytic leukemia, a rare and aggressive leukemia with a median survival of less than one year, require immediate treatment. T-cell prolymphocytic leukemia is difficult to treat, and it does not respond to most available chemotherapeutic drugs. Many different treatments have been attempted, with limited success in certain people: purine analogues (pentostatin, fludarabine, cladribine), chlorambucil , and various forms of combination chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone CHOP , cyclophosphamide, vincristine, prednisone [COP], vincristine, doxorubicin, prednisone, etoposide, cyclophosphamide, bleomycin VAPEC-B ). Alemtuzumab (Campath),

16644-643: The generation, transmission, and use of electrical power. They concluded that there is limited evidence that high levels of ELF magnetic (but not electric) fields might cause some cases of childhood leukemia . No evidence for a relationship to leukemia or another form of malignancy in adults has been demonstrated. Since exposure to such levels of ELFs is relatively uncommon, the World Health Organization concludes that ELF exposure, if later proven to be causative, would account for just 100 to 2400 cases worldwide each year, representing 0.2 to 4.9% of

16790-443: The hope of a permanent cure. Many different anti-cancer drugs are effective for the treatment of AML. Treatments vary somewhat according to the age of the person and according to the specific subtype of AML. Overall, the strategy is to control bone marrow and systemic (whole-body) disease, while offering specific treatment for the central nervous system (CNS), if involved. In general, most oncologists rely on combinations of drugs for

16936-679: The hypothalamus and elevate the thermoregulatory setpoint. An example of a class of exogenous pyrogens are bacterial lipopolysaccharides (LPS) present in the cell wall of gram-negative bacteria . According to one mechanism of pyrogen action, an immune system protein, lipopolysaccharide-binding protein (LBP), binds to LPS, and the LBP–LPS complex then binds to a CD14 receptor on a macrophage . The LBP-LPS binding to CD14 results in cellular synthesis and release of various endogenous cytokines , e.g., interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNFα). A further downstream event

17082-443: The immune response of the body is to inhibit their growth and eliminate them. The most common pyrogens are endotoxins, which are lipopolysaccharides (LPS) produced by Gram-negative bacteria such as E. coli . But pyrogens include non-endotoxic substances (derived from microorganisms other than gram-negative-bacteria or from chemical substances) as well. The types of pyrogens include internal (endogenous) and external (exogenous) to

17228-408: The immune system from working normally, some people experience frequent infection , ranging from infected tonsils , sores in the mouth , or diarrhea to life-threatening pneumonia or opportunistic infections . Finally, the red blood cell deficiency leads to anemia , which may cause dyspnea and pallor . Some people experience other symptoms, such as fevers, chills, night sweats, weakness in

17374-422: The induction phase. There are many possible treatments for CML, but the standard of care for newly diagnosed people is imatinib (Gleevec) therapy. Compared to most anti-cancer drugs, it has relatively few side effects and can be taken orally at home. With this drug, more than 90% of people will be able to keep the disease in check for at least five years, so that CML becomes a chronic, manageable condition. In

17520-685: The influence of the American labor movement and King O'Malley . On top of that, some place names in South Australia such as Victor Harbor , Franklin Harbor or Outer Harbor are usually spelled with the -or spellings. Aside from that, -our is now almost universal in Australia but the -or endings remain a minority variant. New Zealand English , while sharing some words and syntax with Australian English , follows British usage. In British English, some words from French, Latin or Greek end with

17666-495: The initial, induction phase of chemotherapy. Such combination chemotherapy usually offers the benefits of early remission and a lower risk of disease resistance. Consolidation and maintenance treatments are intended to prevent disease recurrence. Consolidation treatment often entails a repetition of induction chemotherapy or the intensification of chemotherapy with additional drugs. By contrast, maintenance treatment involves drug doses that are lower than those administered during

17812-399: The likelihood of permanent damage from typical fevers. The underlying problem, according to professor of pediatrics Barton D. Schmitt, is that "as parents we tend to suspect that our children's brains may melt." As a result of these misconceptions parents are anxious, give the child fever-reducing medicine when the temperature is technically normal or only slightly elevated, and interfere with

17958-559: The limbs, feeling fatigued and other common flu-like symptoms . Some people experience nausea or a feeling of fullness due to an enlarged liver and spleen ; this can result in unintentional weight loss . Blasts affected by the disease may come together and become swollen in the liver or in the lymph nodes causing pain and leading to nausea. If the leukemic cells invade the central nervous system , then neurological symptoms (notably headaches ) can occur. Uncommon neurological symptoms like migraines , seizures , or coma can occur as

18104-414: The nature of the suffix used. The u is kept before English suffixes that are freely attachable to English words (for example in humourless , neighbourhood , and savoury ) and suffixes of Greek or Latin origin that have been adopted into English (for example in behaviourism , favourite , and honourable ). However, before Latin suffixes that are not freely attachable to English words,

18250-519: The next week, and so on, where the generality of this pattern is debated. Persistent fever that cannot be explained after repeated routine clinical inquiries is called fever of unknown origin . A neutropenic fever , also called febrile neutropenia, is a fever in the absence of normal immune system function. Because of the lack of infection-fighting neutrophils , a bacterial infection can spread rapidly; this fever is, therefore, usually considered to require urgent medical attention. This kind of fever

18396-402: The normal production of blood cells, but they remain in the marrow instead of entering the bloodstream, where they would be visible in a blood test. For a person with aleukemia, the white blood cell counts in the bloodstream can be normal or low. Aleukemia can occur in any of the four major types of leukemia, and is particularly common in hairy cell leukemia . Studies in 2009 and 2010 have shown

18542-462: The pregnancy) have been reported. Children born to mothers who use fertility drugs to induce ovulation are more than twice as likely to develop leukemia during their childhoods than other children. In a recent systematic review and meta-analysis of any type of leukemia in neonates using phototherapy , typically to treat neonatal jaundice , a statistically significant association was detected between using phototherapy and myeloid leukemia. However, it

18688-503: The reverse of the foregoing processes (e.g., vasodilation, end of shivering, and nonshivering heat production) are used to cool the body to the new, lower setting. This contrasts with hyperthermia , in which the normal setting remains, and the body overheats through undesirable retention of excess heat or over-production of heat. Hyperthermia is usually the result of an excessively hot environment ( heat stroke ) or an adverse reaction to drugs. Fever can be differentiated from hyperthermia by

18834-475: The simplified form palestra is described by Merriam-Webster as "chiefly Brit[ish]." This is a reverse of the typical rule, where British spelling uses the ae / oe and American spelling simply uses e . Words that can be spelled either way in British English include cham a eleon , encyclop a edia , hom o eopathy , medi a eval (a minor variant in both AmE and BrE ), f o etid and f o etus . The spellings f o etus and f o etal are Britishisms based on

18980-410: The sounds became monophthongs , and later applied to words not of Greek origin, in both Latin (for example, cœli ) and French (for example, œuvre ). In English, which has adopted words from all three languages, it is now usual to replace Æ/æ with Ae/ae and Œ/œ with Oe/oe . In many words, the digraph has been reduced to a lone e in all varieties of English: for example, o economics , pr

19126-695: The spelling "is often seen as such". The -ize form is known as Oxford spelling and is used in publications of the Oxford University Press, most notably the Oxford English Dictionary , and of other academic publishers such as Nature , the Biochemical Journal and The Times Literary Supplement . It can be identified using the IETF language tag en-GB-oxendict (or, historically, by en-GB-oed ). In Ireland, India, Australia, and New Zealand -ise spellings strongly prevail:

19272-608: The spellings with just e are increasingly used. Manoeuvre is the only spelling in Australia, and the most common one in Canada, where maneuver and manoeuver are also sometimes found. The -ize spelling is often incorrectly seen in Britain as an Americanism. It has been in use since the 15th century, predating the -ise spelling by over a century. The verb-forming suffix -ize comes directly from Ancient Greek -ίζειν ( -ízein ) or Late Latin -izāre , while -ise comes via French -iser . The Oxford English Dictionary ( OED ) recommends -ize and lists

19418-473: The temperature set point, due to either too much heat production or not enough heat loss . Hyperthermia is thus not considered fever. Hyperthermia should not be confused with hyperpyrexia (which is a very high fever). Clinically, it is important to distinguish between fever and hyperthermia as hyperthermia may quickly lead to death and does not respond to antipyretic medications. The distinction may however be difficult to make in an emergency setting, and

19564-534: The total incidence of childhood leukemia for that year (about 0.03 to 0.9% of all leukemias). Diagnosis is usually based on repeated complete blood counts and a bone marrow examination following observations of the symptoms. Sometimes, blood tests may not show that a person has leukemia, especially in the early stages of the disease or during remission. A lymph node biopsy can be performed to diagnose certain types of leukemia in certain situations. Following diagnosis, blood chemistry tests can be used to determine

19710-405: The type of leukemia and the age of the person. Outcomes have improved in the developed world. Five-year survival rate was 67% in the United States in the period from 2014 to 2020. In children under 15 in first-world countries, the five-year survival rate is greater than 60% or even 90%, depending on the type of leukemia. In children who are cancer-free five years after diagnosis of acute leukemia,

19856-406: The type of leukemia and the age of the person. Outcomes have improved in the developed world. The average five-year survival rate is 65% in the United States. In children under 15, the five-year survival rate is greater (60 to 85%), depending on the type of leukemia. In children with acute leukemia who are cancer-free after five years, the cancer is unlikely to return. Outcomes depend on whether it

20002-412: The vowel is unreduced in pronunciation (e.g., devour , contour , flour , hour , paramour , tour , troubadour , and velour ), the spelling is uniform everywhere. Most words of this kind came from Latin, where the ending was spelled ‑or . They were first adopted into English from early Old French , and the ending was spelled ‑our , ‑or or ‑ur . After the Norman conquest of England ,

20148-624: The word fiord (instead of fjord ) . There is an increasing use of macrons in words that originated in Māori and an unambiguous preference for -ise endings (see below). Most words ending in an unstressed ‑our in British English (e.g., behaviour , colour , favour , flavour , harbour , honour , humour , labour , neighbour , rumour , splendour ) end in ‑or in American English ( behavior , color , favor , flavor , harbor , honor , humor , labor , neighbor , rumor , splendor ). Wherever

20294-428: The word pallor . As a general noun, rigour / ˈ r ɪ ɡ ər / has a u in the UK; the medical term rigor (sometimes / ˈ r aɪ ɡ ər / ) does not, such as in rigor mortis , which is Latin. Derivations of rigour / rigor such as rigorous , however, are typically spelled without a u , even in the UK. Words with the ending -irior , -erior or similar are spelled thus everywhere. The word armour

20440-540: The world developed a form of leukemia, and 209,000 died from it. This represents about 3% of the almost seven million deaths due to cancer that year, and about 0.35% of all deaths from any cause. Of the sixteen separate sites the body compared, leukemia was the 12th most common class of neoplastic disease and the 11th most common cause of cancer-related death. Leukemia occurs more commonly in the developed world . American and British English spelling differences#ae and oe A "British standard" began to emerge following

20586-588: Was not until the mid-1990s that Canadian-based dictionaries became increasingly common.) Worldwide, -ize endings prevail in scientific writing and are commonly used by many international organizations, such as United Nations Organizations (such as the World Health Organization and the International Civil Aviation Organization ) and the International Organization for Standardization (but not by

20732-428: Was once somewhat common in American usage but has disappeared except in some brand names such as Under Armour . The agent suffix -or ( separator , elevator , translator , animator , etc.) is spelled thus both in American and British English. Commonwealth countries normally follow British usage. Canadian English most commonly uses the -our ending and -our- in derivatives and inflected forms. However, owing to

20878-425: Was practicing medicine including that due to malaria (tertian or every 2 days and quartan or every 3 days). It also became clear around this time that fever was a symptom of disease rather than a disease in and of itself. Infections presenting with fever were a major source of mortality in humans for about 200,000 years. Until the late nineteenth century, approximately half of all humans died from infections before

21024-929: Was published. Following this, -re became the most common usage in Britain. In the United States, following the publication of Webster's Dictionary in the early 19th century, American English became more standardized, exclusively using the -er spelling. In addition, spelling of some words have been changed from -re to -er in both varieties. These include September , October , November , December , amber, blister , cadaver , chamber , chapter , charter , cider , coffer , coriander , cover , cucumber , cylinder , diaper , disaster , enter , fever , filter , gender , leper , letter , lobster , master , member , meter (measuring instrument) , minister , monster , murder , number , offer , order , oyster , powder , proper , render , semester , sequester , sinister , sober , surrender , tender , and tiger . Words using

21170-643: Was terminated early because patients receiving aggressive fever treatment were dying more often. According to the NIH, the two assumptions which are generally used to argue in favor of treating fevers have not been experimentally validated. These are that (1) a fever is noxious, and (2) suppression of a fever will reduce its noxious effect. Most of the other studies supporting the association of fever with poorer outcomes have been observational in nature. In theory, these critically ill patients and those faced with additional physiologic stress may benefit from fever reduction, but

21316-437: Was very influential in popularizing certain spellings in the United States, but he did not originate them. Rather [...] he chose already existing options such as center, color and check for the simplicity, analogy or etymology". William Shakespeare 's first folios , for example, used spellings such as center and color as much as centre and colour . Webster did attempt to introduce some reformed spellings, as did

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