208-444: Biology is the scientific study of life . It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of at least one cell that processes hereditary information encoded in genes , which can be transmitted to future generations. Another major theme is evolution , which explains the unity and diversity of life. Energy processing
416-420: A double helix . The two DNA strands are known as polynucleotides since they are composed of simpler units called nucleotides . Each nucleotide is composed of a nitrogen-containing nucleobase —either cytosine (C), guanine (G), adenine (A), or thymine (T)—as well as a sugar called deoxyribose and a phosphate group . The nucleotides are joined to one another in a chain by covalent bonds between
624-532: A last universal common ancestor that lived about 3.5 billion years ago . Geologists have developed a geologic time scale that divides the history of the Earth into major divisions, starting with four eons ( Hadean , Archean , Proterozoic , and Phanerozoic ), the first three of which are collectively known as the Precambrian , which lasted approximately 4 billion years. Each eon can be divided into eras, with
832-439: A lipid bilayer , including cholesterols that sit between phospholipids to maintain their fluidity at various temperatures. Cell membranes are semipermeable , allowing small molecules such as oxygen, carbon dioxide, and water to pass through while restricting the movement of larger molecules and charged particles such as ions . Cell membranes also contain membrane proteins , including integral membrane proteins that go across
1040-420: A living systems theory viewpoint that does not necessarily depend on molecular chemistry. One systemic definition of life is that living things are self-organizing and autopoietic (self-producing). Variations of this include Stuart Kauffman 's definition as an autonomous agent or a multi-agent system capable of reproducing itself, and of completing at least one thermodynamic work cycle . This definition
1248-428: A nucleus and other membrane-bound organelles , although they have circular DNA and ribosomes . Bacteria and Archaea are two domains of prokaryotes. The other primary type is the eukaryote cell, which has a distinct nucleus bound by a nuclear membrane and membrane-bound organelles, including mitochondria , chloroplasts , lysosomes , rough and smooth endoplasmic reticulum , and vacuoles . In addition, their DNA
1456-442: A nucleus , and prokaryotic cells, which do not. Prokaryotes are single-celled organisms such as bacteria , whereas eukaryotes can be single-celled or multicellular. In multicellular organisms , every cell in the organism's body is derived ultimately from a single cell in a fertilized egg . Every cell is enclosed within a cell membrane that separates its cytoplasm from the extracellular space . A cell membrane consists of
1664-507: A number of shapes , ranging from spheres to rods and spirals . Bacteria were among the first life forms to appear on Earth, and are present in most of its habitats . Bacteria inhabit soil, water, acidic hot springs , radioactive waste , and the deep biosphere of the Earth's crust . Bacteria also live in symbiotic and parasitic relationships with plants and animals. Most bacteria have not been characterised, and only about 27 percent of
1872-403: A universal common ancestor . This evolved into all the species that exist now, by way of many extinct species, some of which have left traces as fossils . Attempts to classify living things, too, began with Aristotle . Modern classification began with Carl Linnaeus 's system of binomial nomenclature in the 1740s. Living things are composed of biochemical molecules , formed mainly from
2080-473: A cell's size, shape, membrane potential , metabolic activity , and responsiveness to signals, which are largely due to highly controlled modifications in gene expression and epigenetics . With a few exceptions, cellular differentiation almost never involves a change in the DNA sequence itself. Thus, different cells can have very different physical characteristics despite having the same genome . Morphogenesis, or
2288-405: A chemical (e.g., nitrous acid , benzopyrene ) or radiation (e.g., x-ray , gamma ray , ultraviolet radiation , particles emitted by unstable isotopes). Mutations can lead to phenotypic effects such as loss-of-function, gain-of-function , and conditional mutations. Some mutations are beneficial, as they are a source of genetic variation for evolution. Others are harmful if they were to result in
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#17327730288632496-407: A common origin. All life forms require certain core chemical elements for their biochemical functioning. These include carbon , hydrogen , nitrogen , oxygen , phosphorus , and sulfur —the elemental macronutrients for all organisms. Together these make up nucleic acids , proteins and lipids , the bulk of living matter. Five of these six elements comprise the chemical components of DNA,
2704-476: A consequence of these microbial activities, the physical-chemical environment on Earth has been changing on a geologic time scale , thereby affecting the path of evolution of subsequent life. For example, the release of molecular oxygen by cyanobacteria as a by-product of photosynthesis induced global changes in the Earth's environment. Because oxygen was toxic to most life on Earth at the time, this posed novel evolutionary challenges, and ultimately resulted in
2912-1231: A few archaea have very different shapes, such as the flat and square cells of Haloquadratum walsbyi . Despite this morphological similarity to bacteria, archaea possess genes and several metabolic pathways that are more closely related to those of eukaryotes, notably for the enzymes involved in transcription and translation . Other aspects of archaeal biochemistry are unique, such as their reliance on ether lipids in their cell membranes , including archaeols . Archaea use more energy sources than eukaryotes: these range from organic compounds , such as sugars, to ammonia , metal ions or even hydrogen gas . Salt-tolerant archaea (the Haloarchaea ) use sunlight as an energy source, and other species of archaea fix carbon , but unlike plants and cyanobacteria , no known species of archaea does both. Archaea reproduce asexually by binary fission , fragmentation , or budding ; unlike bacteria, no known species of Archaea form endospores . The first observed archaea were extremophiles , living in extreme environments, such as hot springs and salt lakes with no other organisms. Improved molecular detection tools led to
3120-656: A few core chemical elements . All living things contain two types of large molecule, proteins and nucleic acids , the latter usually both DNA and RNA : these carry the information needed by each species, including the instructions to make each type of protein. The proteins, in turn, serve as the machinery which carries out the many chemical processes of life. The cell is the structural and functional unit of life. Smaller organisms, including prokaryotes (bacteria and archaea ), consist of small single cells. Larger organisms , mainly eukaryotes , can consist of single cells or may be multicellular with more complex structure. Life
3328-400: A hollow sphere of cells , the blastula , during embryonic development . Over 1.5 million living animal species have been described —of which around 1 million are insects —but it has been estimated there are over 7 million animal species in total. They have complex interactions with each other and their environments, forming intricate food webs . Life Life on Earth: Life
3536-442: A host cell to make new products. Virus self-assembly within host cells has implications for the study of the origin of life , as it may support the hypothesis that life could have started as self-assembling organic molecules . Some of the earliest theories of life were materialist, holding that all that exists is matter, and that life is merely a complex form or arrangement of matter. Empedocles (430 BC) argued that everything in
3744-456: A kind of foam itself (composed, as it was, from a mixture of water and pneuma ). For Aristotle, the generative materials of male and female animals (semen and menstrual fluid) were essentially refinements, made by male and female bodies according to their respective proportions of heat, of ingested food, which was, in turn, a byproduct of the elements earth and water. Thus any creature, whether generated sexually from parents or spontaneously through
3952-764: A loss of function of genes needed for survival. Gene expression is the molecular process by which a genotype encoded in DNA gives rise to an observable phenotype in the proteins of an organism's body. This process is summarized by the central dogma of molecular biology , which was formulated by Francis Crick in 1958. According to the Central Dogma, genetic information flows from DNA to RNA to protein. There are two gene expression processes: transcription (DNA to RNA) and translation (RNA to protein). The regulation of gene expression by environmental factors and during different stages of development can occur at each step of
4160-472: A matter of debate; viruses lack characteristics of life such as cell membranes, metabolism and the ability to grow or respond to their environments. Viruses have been classed into "species" based on their genetics , but many aspects of such a classification remain controversial. The original Linnaean system has been modified many times, for example as follows: The attempt to organise the Eukaryotes into
4368-415: A meat broth in a swan neck flask ; the bend in the neck of the flask prevented falling particles from reaching the broth, while still allowing the free flow of air. The flask remained free of growth for an extended period. When the flask was turned so that particles could fall down the bends, the broth quickly became clouded. However, minority objections were persistent and not always unreasonable, given that
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#17327730288634576-535: A month in a simulated Martian environment . Beyond the Solar System, the region around another main-sequence star that could support Earth-like life on an Earth-like planet is known as the habitable zone . The inner and outer radii of this zone vary with the luminosity of the star, as does the time interval during which the zone survives. Stars more massive than the Sun have a larger habitable zone, but remain on
4784-413: A more successful evolutionary theory based on natural selection ; similar reasoning and evidence led Alfred Russel Wallace to independently reach the same conclusions. The basis for modern genetics began with the work of Gregor Mendel in 1865. This outlined the principles of biological inheritance. However, the significance of his work was not realized until the early 20th century when evolution became
4992-456: A new cycle. In contrast to mitosis, meiosis results in four haploid daughter cells by undergoing one round of DNA replication followed by two divisions. Homologous chromosomes are separated in the first division ( meiosis I ), and sister chromatids are separated in the second division ( meiosis II ). Both of these cell division cycles are used in the process of sexual reproduction at some point in their life cycle. Both are believed to be present in
5200-466: A parent, is needed. Supposed examples included the seasonal generation of mice and other animals from the mud of the Nile , the emergence of fleas from inanimate matter such as dust, or the appearance of maggots in dead flesh. Such ideas have something in common with the modern hypothesis of the origin of life , which asserts that life emerged some four billion years ago from non-living materials, over
5408-407: A process known as allopatric speciation . A phylogeny is an evolutionary history of a specific group of organisms or their genes. It can be represented using a phylogenetic tree , a diagram showing lines of descent among organisms or their genes. Each line drawn on the time axis of a tree represents a lineage of descendants of a particular species or population. When a lineage divides into two, it
5616-463: A range of creatures from different sorts of inanimate matter. The testaceans (a genus which for Aristotle included bivalves and snails), for instance, were characterized by spontaneous generation from mud, but differed based upon the precise material they grew in—for example, clams and scallops in sand, oysters in slime, and the barnacle and the limpet in the hollows of rocks. Athenaeus dissented towards spontaneous generation, claiming that
5824-461: A recipe for mice (a piece of dirty cloth plus wheat for 21 days) and scorpions ( basil , placed between two bricks and left in sunlight). His notes suggest he may have attempted to do these things. Where Aristotle held that the embryo was formed by a coagulation in the uterus , the English physician William Harvey showed by way of dissection of deer that there was no visible embryo during
6032-407: A region of deoxyribonucleic acid (DNA) that carries genetic information that controls form or function of an organism. DNA is composed of two polynucleotide chains that coil around each other to form a double helix . It is found as linear chromosomes in eukaryotes , and circular chromosomes in prokaryotes . The set of chromosomes in a cell is collectively known as its genome . In eukaryotes, DNA
6240-452: A resurgence of interest in the work of Russell, Barge and colleagues. Hylomorphism is a theory first expressed by the Greek philosopher Aristotle (322 BC). The application of hylomorphism to biology was important to Aristotle, and biology is extensively covered in his extant writings . In this view, everything in the material universe has both matter and form, and the form of a living thing
6448-540: A role in the synthesis and packaging of proteins, respectively. Biomolecules such as proteins can be engulfed by lysosomes , another specialized organelle. Plant cells have additional organelles that distinguish them from animal cells such as a cell wall that provides support for the plant cell, chloroplasts that harvest sunlight energy to produce sugar, and vacuoles that provide storage and structural support as well as being involved in reproduction and breakdown of plant seeds. Eukaryotic cells also have cytoskeleton that
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6656-433: A separate clade as some protists may be more closely related to plants, fungi, or animals than they are to other protists. Like groupings such as algae , invertebrates , or protozoans , the protist grouping is not a formal taxonomic group but is used for convenience. Most protists are unicellular; these are called microbial eukaryotes. Plants are mainly multicellular organisms , predominantly photosynthetic eukaryotes of
6864-809: A set of 355 genes from the last universal common ancestor was tentatively identified. The biosphere is postulated to have developed, from the origin of life onwards, at least some 3.5 billion years ago. The earliest evidence for life on Earth includes biogenic graphite found in 3.7 billion-year-old metasedimentary rocks from Western Greenland and microbial mat fossils found in 3.48 billion-year-old sandstone from Western Australia . More recently, in 2015, "remains of biotic life " were found in 4.1 billion-year-old rocks in Western Australia. In 2017, putative fossilised microorganisms (or microfossils ) were announced to have been discovered in hydrothermal vent precipitates in
7072-619: A short period Linnaeus had classified them in the taxon Vermes in Animalia, but later placed them back in Plantae. Herbert Copeland classified the Fungi in his Protoctista , including them with single-celled organisms and thus partially avoiding the problem but acknowledging their special status. The problem was eventually solved by Whittaker , when he gave them their own kingdom in his five-kingdom system . Evolutionary history shows that
7280-423: A single carbon atom can form four single covalent bonds such as in methane , two double covalent bonds such as in carbon dioxide (CO 2 ), or a triple covalent bond such as in carbon monoxide (CO). Moreover, carbon can form very long chains of interconnecting carbon–carbon bonds such as octane or ring-like structures such as glucose . The simplest form of an organic molecule is the hydrocarbon , which
7488-462: A single form approximately four billion years ago, attention has instead turned to the origin of life . "Spontaneous generation" means both the supposed processes by which different types of life might repeatedly emerge from specific sources other than seeds, eggs, or parents, and the theoretical principles presented in support of any such phenomena. Crucial to this doctrine are the ideas that life comes from non-life and that no causal agent, such as
7696-467: A small number of kingdoms has been challenged. The Protozoa do not form a clade or natural grouping, and nor do the Chromista (Chromalveolata). The ability to sequence large numbers of complete genomes has allowed biologists to take a metagenomic view of the phylogeny of the whole tree of life . This has led to the realisation that the majority of living things are bacteria, and that all have
7904-446: A specific enzyme. Enzymes are crucial to metabolism because they allow organisms to drive desirable reactions that require energy that will not occur by themselves, by coupling them to spontaneous reactions that release energy. Enzymes act as catalysts —they allow a reaction to proceed more rapidly without being consumed by it—by reducing the amount of activation energy needed to convert reactants into products . Enzymes also allow
8112-408: A thousand years. In the late 1740s, Carl Linnaeus introduced his system of binomial nomenclature for the classification of species. Linnaeus attempted to improve the composition and reduce the length of the previously used many-worded names by abolishing unnecessary rhetoric, introducing new descriptive terms and precisely defining their meaning. The fungi were originally treated as plants. For
8320-602: A time span of millions of years, and subsequently diversified into all the forms that now exist. The term equivocal generation , sometimes known as heterogenesis or xenogenesis , describes the supposed process by which one form of life arises from a different, unrelated form, such as tapeworms from the bodies of their hosts. Active in the 6th and 5th centuries BCE, early Greek philosophers, called physiologoi in antiquity (Greek: φυσιολόγοι; in English, physical or natural philosophers ), attempted to give natural explanations of phenomena that had previously been ascribed to
8528-415: A unified theory as the modern synthesis reconciled Darwinian evolution with classical genetics . In the 1940s and early 1950s, a series of experiments by Alfred Hershey and Martha Chase pointed to DNA as the component of chromosomes that held the trait-carrying units that had become known as genes . A focus on new kinds of model organisms such as viruses and bacteria, along with the discovery of
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8736-419: A varied mix of traits, and reproduction is able to increase any population, Darwin argued that in the natural world, it was nature that played the role of humans in selecting for specific traits. Darwin inferred that individuals who possessed heritable traits better adapted to their environments are more likely to survive and produce more offspring than other individuals. He further inferred that this would lead to
8944-500: A variety of anchovy did not generate from roe , as Aristotle stated, but rather, from sea foam . As the dominant view of philosophers and thinkers continued to be in favour of spontaneous generation, some Christian theologians accepted the view. The Berber theologian and philosopher Augustine of Hippo discussed spontaneous generation in The City of God and The Literal Meaning of Genesis , citing Biblical passages such as "Let
9152-486: A water molecule again. In pure water , the number of hydrogen ions balances (or equals) the number of hydroxyl ions, resulting in a pH that is neutral. Organic compounds are molecules that contain carbon bonded to another element such as hydrogen. With the exception of water, nearly all the molecules that make up each organism contain carbon. Carbon can form covalent bonds with up to four other atoms, enabling it to form diverse, large, and complex molecules. For example,
9360-442: Is a central feature of sexual reproduction in eukaryotes, and the most fundamental function of meiosis appears to be conservation of the integrity of the genome that is passed on to progeny by parents. Two aspects of sexual reproduction , meiotic recombination and outcrossing , are likely maintained respectively by the adaptive advantages of recombinational repair of genomic DNA damage and genetic complementation which masks
9568-638: Is a large family of organic compounds that are composed of hydrogen atoms bonded to a chain of carbon atoms. A hydrocarbon backbone can be substituted by other elements such as oxygen (O), hydrogen (H), phosphorus (P), and sulfur (S), which can change the chemical behavior of that compound. Groups of atoms that contain these elements (O-, H-, P-, and S-) and are bonded to a central carbon atom or skeleton are called functional groups . There are six prominent functional groups that can be found in organisms: amino group , carboxyl group , carbonyl group , hydroxyl group , phosphate group , and sulfhydryl group . In 1953,
9776-473: Is a mechanistic explanation for the origin of species by means of natural selection . At the beginning of the 20th century Stéphane Leduc (1853–1939) promoted the idea that biological processes could be understood in terms of physics and chemistry, and that their growth resembled that of inorganic crystals immersed in solutions of sodium silicate. His ideas, set out in his book La biologie synthétique , were widely dismissed during his lifetime, but has incurred
9984-610: Is a quality that distinguishes matter that has biological processes , such as signaling and self-sustaining processes, from matter that does not. It is defined descriptively by the capacity for homeostasis , organisation , metabolism , growth , adaptation , response to stimuli , and reproduction . All life over time eventually reaches a state of death , and none is immortal . Many philosophical definitions of living systems have been proposed, such as self-organizing systems. Viruses in particular make definition difficult as they replicate only in host cells. Life exists all over
10192-477: Is a small polar molecule with a bent shape formed by the polar covalent bonds of two hydrogen (H) atoms to one oxygen (O) atom (H 2 O). Because the O–H bonds are polar, the oxygen atom has a slight negative charge and the two hydrogen atoms have a slight positive charge. This polar property of water allows it to attract other water molecules via hydrogen bonds, which makes water cohesive . Surface tension results from
10400-913: Is a term of convenience as not all algae are closely related. Algae comprise several distinct clades such as glaucophytes , which are microscopic freshwater algae that may have resembled in form to the early unicellular ancestor of Plantae. Unlike glaucophytes, the other algal clades such as red and green algae are multicellular. Green algae comprise three major clades: chlorophytes , coleochaetophytes , and stoneworts . Fungi are eukaryotes that digest foods outside their bodies, secreting digestive enzymes that break down large food molecules before absorbing them through their cell membranes. Many fungi are also saprobes , feeding on dead organic matter, making them important decomposers in ecological systems. Animals are multicellular eukaryotes. With few exceptions, animals consume organic material , breathe oxygen , are able to move , can reproduce sexually , and grow from
10608-561: Is about 4.54 billion years . Life on Earth has existed for at least 3.5 billion years, with the oldest physical traces of life dating back 3.7 billion years. Estimates from molecular clocks, as summarised in the TimeTree public database, place the origin of life around 4.0 billion years ago. Hypotheses on the origin of life attempt to explain the formation of a universal common ancestor from simple organic molecules via pre-cellular life to protocells and metabolism. In 2016,
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#173277302886310816-402: Is absorbed by chlorophyll pigments attached to proteins in the thylakoid membranes . The absorbed light energy is used to remove electrons from a donor (water) to a primary electron acceptor, a quinone designated as Q. In the second stage, electrons move from the quinone primary electron acceptor through a series of electron carriers until they reach a final electron acceptor, which is usually
11024-438: Is also important to life as it allows organisms to move , grow, and reproduce . Finally, all organisms are able to regulate their own internal environments . Biologists are able to study life at multiple levels of organization , from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations. Hence, there are multiple subdisciplines within biology , each defined by
11232-558: Is capable of forming the various specialised cells that form the adult organism. This specialisation allows multicellular organisms to exploit resources more efficiently than single cells. About 800 million years ago, a minor genetic change in a single molecule, the enzyme GK-PID , may have allowed organisms to go from a single cell organism to one of many cells. Cells have evolved methods to perceive and respond to their microenvironment, thereby enhancing their adaptability. Cell signalling coordinates cellular activities, and hence governs
11440-402: Is catalyzed by lactate dehydrogenase in a reversible reaction. Lactate can also be used as an indirect precursor for liver glycogen. During recovery, when oxygen becomes available, NAD attaches to hydrogen from lactate to form ATP. In yeast, the waste products are ethanol and carbon dioxide. This type of fermentation is known as alcoholic or ethanol fermentation . The ATP generated in this process
11648-422: Is considered the starting point of modern organic chemistry . It is of historical significance because for the first time an organic compound was produced in inorganic reactions. During the 1850s Hermann von Helmholtz , anticipated by Julius Robert von Mayer , demonstrated that no energy is lost in muscle movement, suggesting that there were no "vital forces" necessary to move a muscle. These results led to
11856-421: Is extended by the evolution of novel functions over time. Death is the termination of all vital functions or life processes in an organism or cell. One of the challenges in defining death is in distinguishing it from life. Death would seem to refer to either the moment life ends, or when the state that follows life begins. However, determining when death has occurred is difficult, as cessation of life functions
12064-425: Is its soul (Greek psyche , Latin anima ). There are three kinds of souls: the vegetative soul of plants, which causes them to grow and decay and nourish themselves, but does not cause motion and sensation; the animal soul , which causes animals to move and feel; and the rational soul , which is the source of consciousness and reasoning, which (Aristotle believed) is found only in man. Each higher soul has all of
12272-438: Is made by substrate-level phosphorylation , which does not require oxygen. Photosynthesis is a process used by plants and other organisms to convert light energy into chemical energy that can later be released to fuel the organism's metabolic activities via cellular respiration. This chemical energy is stored in carbohydrate molecules, such as sugars, which are synthesized from carbon dioxide and water. In most cases, oxygen
12480-532: Is made up of microtubules , intermediate filaments , and microfilaments , all of which provide support for the cell and are involved in the movement of the cell and its organelles. In terms of their structural composition, the microtubules are made up of tubulin (e.g., α-tubulin and β-tubulin ) whereas intermediate filaments are made up of fibrous proteins. Microfilaments are made up of actin molecules that interact with other strands of proteins. All cells require energy to sustain cellular processes. Metabolism
12688-521: Is mainly in the cell nucleus . In prokaryotes, the DNA is held within the nucleoid . The genetic information is held within genes, and the complete assemblage in an organism is called its genotype . DNA replication is a semiconservative process whereby each strand serves as a template for a new strand of DNA. Mutations are heritable changes in DNA. They can arise spontaneously as a result of replication errors that were not corrected by proofreading or can be induced by an environmental mutagen such as
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#173277302886312896-407: Is most likely to exist, within wide bounds of uncertainty. A "Confidence of Life Detection" scale (CoLD) for reporting evidence of life beyond Earth has been proposed. Artificial life is the simulation of any aspect of life, as through computers, robotics , or biochemistry . Synthetic biology is a new area of biotechnology that combines science and biological engineering . The common goal
13104-476: Is not only plausible, but probable or inevitable, possibly resulting in a biophysical cosmology instead of a mere physical cosmology . Other planets and moons in the Solar System and other planetary systems are being examined for evidence of having once supported simple life, and projects such as SETI are trying to detect radio transmissions from possible alien civilisations. Other locations within
13312-428: Is often not simultaneous across organ systems. Such determination, therefore, requires drawing conceptual lines between life and death. This is problematic because there is little consensus over how to define life. The nature of death has for millennia been a central concern of the world's religious traditions and of philosophical inquiry. Many religions maintain faith in either a kind of afterlife or reincarnation for
13520-399: Is one of the key ways a cell releases chemical energy to fuel cellular activity. The overall reaction occurs in a series of biochemical steps, some of which are redox reactions. Although cellular respiration is technically a combustion reaction , it clearly does not resemble one when it occurs in a cell because of the slow, controlled release of energy from the series of reactions. Sugar in
13728-580: Is only known to exist on Earth but extraterrestrial life is thought probable . Artificial life is being simulated and explored by scientists and engineers. The definition of life has long been a challenge for scientists and philosophers. This is partially because life is a process, not a substance. This is complicated by a lack of knowledge of the characteristics of living entities, if any, that may have developed outside Earth. Philosophical definitions of life have also been put forward, with similar difficulties on how to distinguish living things from
13936-485: Is organised into chromosomes . All species of large complex organisms are eukaryotes, including animals, plants and fungi, though with a wide diversity of protist microorganisms . The conventional model is that eukaryotes evolved from prokaryotes, with the main organelles of the eukaryotes forming through endosymbiosis between bacteria and the progenitor eukaryotic cell. The molecular mechanisms of cell biology are based on proteins . Most of these are synthesised by
14144-406: Is pulled to the separate poles of the bacterium as it increases the size to prepare for splitting. Growth of a new cell wall begins to separate the bacterium (triggered by FtsZ polymerization and "Z-ring" formation). The new cell wall ( septum ) fully develops, resulting in the complete split of the bacterium. The new daughter cells have tightly coiled DNA rods, ribosomes , and plasmids . Meiosis
14352-453: Is released as a waste product. Most plants, algae , and cyanobacteria perform photosynthesis, which is largely responsible for producing and maintaining the oxygen content of the Earth's atmosphere, and supplies most of the energy necessary for life on Earth. Photosynthesis has four stages: Light absorption , electron transport, ATP synthesis, and carbon fixation . Light absorption is the initial step of photosynthesis whereby light energy
14560-406: Is represented as a fork or split on the phylogenetic tree. Phylogenetic trees are the basis for comparing and grouping different species. Different species that share a feature inherited from a common ancestor are described as having homologous features (or synapomorphy ). Phylogeny provides the basis of biological classification. This classification system is rank-based, with the highest rank being
14768-417: Is the design and construction of new biological functions and systems not found in nature. Synthetic biology includes the broad redefinition and expansion of biotechnology, with the ultimate goals of being able to design and build engineered biological systems that process information, manipulate chemicals, fabricate materials and structures, produce energy, provide food, and maintain and enhance human health and
14976-467: Is the process by which genes and traits are passed on from parents to offspring. It has several principles. The first is that genetic characteristics, alleles , are discrete and have alternate forms (e.g., purple vs. white or tall vs. dwarf), each inherited from one of two parents. Based on the law of dominance and uniformity , which states that some alleles are dominant while others are recessive ; an organism with at least one dominant allele will display
15184-485: Is the set of chemical reactions in an organism. The three main purposes of metabolism are: the conversion of food to energy to run cellular processes; the conversion of food/fuel to monomer building blocks; and the elimination of metabolic wastes . These enzyme-catalyzed reactions allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolic reactions may be categorized as catabolic —the breaking down of compounds (for example,
15392-409: Is the study of chemical processes within and relating to living organisms . Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including molecular synthesis, modification, mechanisms, and interactions. Life arose from the Earth's first ocean, which formed some 3.8 billion years ago. Since then, water continues to be
15600-434: Is to define life as "a self-sustained chemical system capable of undergoing Darwinian evolution ", a definition adopted by a NASA committee attempting to define life for the purposes of exobiology , based on a suggestion by Carl Sagan . This definition, however, has been widely criticised because according to it, a single sexually reproducing individual is not alive as it is incapable of evolving on its own. Others take
15808-490: Is to store, transmit, and express hereditary information. Cell theory states that cells are the fundamental units of life, that all living things are composed of one or more cells, and that all cells arise from preexisting cells through cell division . Most cells are very small, with diameters ranging from 1 to 100 micrometers and are therefore only visible under a light or electron microscope . There are generally two types of cells: eukaryotic cells, which contain
16016-509: Is unlikely or impossible. Organisms that have a wide range of tolerance are more widely distributed than organisms with a narrow range of tolerance. To survive, some microorganisms have evolved to withstand freezing , complete desiccation , starvation , high levels of radiation exposure , and other physical or chemical challenges. These extremophile microorganisms may survive exposure to such conditions for long periods. They excel at exploiting uncommon sources of energy. Characterization of
16224-414: Is water in earth, and air in water, and in all air is vital heat so that in a sense all things are full of soul. Therefore living things form quickly whenever this air and vital heat are enclosed in anything. When they are so enclosed, the corporeal liquids being heated, there arises as it were a frothy bubble. With varying degrees of observational confidence, Aristotle theorized the spontaneous generation of
16432-465: The History of Animals , many creatures form not through sexual processes but by spontaneous generation: Now there is one property that animals are found to have in common with plants. For some plants are generated from the seed of plants, whilst other plants are self-generated through the formation of some elemental principle similar to a seed; and of these latter plants some derive their nutriment from
16640-639: The Cambrian explosion . During the Permian period, synapsids , including the ancestors of mammals , dominated the land, but most of this group became extinct in the Permian–Triassic extinction event 252 million years ago. During the recovery from this catastrophe, archosaurs became the most abundant land vertebrates; one archosaur group, the dinosaurs, dominated the Jurassic and Cretaceous periods. After
16848-492: The Cretaceous–Paleogene extinction event 66 million years ago killed off the non-avian dinosaurs, mammals increased rapidly in size and diversity . Such mass extinctions may have accelerated evolution by providing opportunities for new groups of organisms to diversify. Bacteria are a type of cell that constitute a large domain of prokaryotic microorganisms . Typically a few micrometers in length, bacteria have
17056-714: The International Ocean Discovery Program found unicellular life in 120 °C sediment 1.2 km below seafloor in the Nankai Trough subduction zone. According to one researcher, "You can find microbes everywhere—they're extremely adaptable to conditions, and survive wherever they are." The inert components of an ecosystem are the physical and chemical factors necessary for life—energy (sunlight or chemical energy ), water, heat, atmosphere , gravity , nutrients , and ultraviolet solar radiation protection . In most ecosystems,
17264-530: The Miller–Urey experiment showed that organic compounds could be synthesized abiotically within a closed system mimicking the conditions of early Earth , thus suggesting that complex organic molecules could have arisen spontaneously in early Earth (see abiogenesis ). Macromolecules are large molecules made up of smaller subunits or monomers . Monomers include sugars, amino acids, and nucleotides. Carbohydrates include monomers and polymers of sugars. Lipids are
17472-504: The Nuvvuagittuq Belt of Quebec, Canada that were as old as 4.28 billion years, the oldest record of life on Earth, suggesting "an almost instantaneous emergence of life" after ocean formation 4.4 billion years ago , and not long after the formation of the Earth 4.54 billion years ago. Evolution is the change in heritable characteristics of biological populations over successive generations. It results in
17680-489: The Precambrian about 1.5 billion years ago and can be classified into eight major clades : alveolates , excavates , stramenopiles , plants, rhizarians , amoebozoans , fungi , and animals. Five of these clades are collectively known as protists , which are mostly microscopic eukaryotic organisms that are not plants, fungi, or animals. While it is likely that protists share a common ancestor (the last eukaryotic common ancestor ), protists by themselves do not constitute
17888-458: The Solar System that may host microbial life include the subsurface of Mars , the upper atmosphere of Venus , and subsurface oceans on some of the moons of the giant planets . Investigation of the tenacity and versatility of life on Earth, as well as an understanding of the molecular systems that some organisms utilise to survive such extremes, is important for the search for extraterrestrial life. For example, lichen could survive for
18096-724: The activator is the transcription factor that stimulates transcription when it binds to the sequence near or at the promoter. Negative regulation occurs when another transcription factor called a repressor binds to a DNA sequence called an operator , which is part of an operon, to prevent transcription. Repressors can be inhibited by compounds called inducers (e.g., allolactose ), thereby allowing transcription to occur. Specific genes that can be activated by inducers are called inducible genes , in contrast to constitutive genes that are almost constantly active. In contrast to both, structural genes encode proteins that are not involved in gene regulation. In addition to regulatory events involving
18304-469: The apeiron, eternally in motion, served as a platform on which elemental opposites (e.g., wet and dry , hot and cold ) generated and shaped the many and varied things in the world. According to Hippolytus of Rome in the third century CE, Anaximander claimed that fish or fish-like creatures were first formed in the "wet" when acted on by the heat of the sun and that these aquatic creatures gave rise to human beings. The Roman author Censorinus , writing in
18512-590: The bacterial phyla have species that can be grown in the laboratory. Archaea constitute the other domain of prokaryotic cells and were initially classified as bacteria, receiving the name archaebacteria (in the Archaebacteria kingdom ), a term that has fallen out of use. Archaeal cells have unique properties separating them from the other two domains , Bacteria and Eukaryota . Archaea are further divided into multiple recognized phyla . Archaea and bacteria are generally similar in size and shape, although
18720-433: The barnacle goose myth was evidence for the virgin birth of Jesus . Where the practice of fasting during Lent allowed fish, but prohibited fowl, the idea that the goose was in fact a fish suggested that its consumption be permitted during Lent. The practice was eventually prohibited by decree of Pope Innocent III in 1215. After Aristotle’s works were reintroduced to Western Europe, they were translated into Latin from
18928-450: The biodiversity of an ecosystem , where they play specialized roles in the cycling of nutrients and energy through their biophysical environment . The earliest of roots of science, which included medicine, can be traced to ancient Egypt and Mesopotamia in around 3000 to 1200 BCE . Their contributions shaped ancient Greek natural philosophy . Ancient Greek philosophers such as Aristotle (384–322 BCE) contributed extensively to
19136-404: The cell . In 1838, Schleiden and Schwann began promoting the now universal ideas that (1) the basic unit of organisms is the cell and (2) that individual cells have all the characteristics of life, although they opposed the idea that (3) all cells come from the division of other cells, continuing to support spontaneous generation . However, Robert Remak and Rudolf Virchow were able to reify
19344-400: The cell membrane of another cell or located deep inside a cell. There are generally four types of chemical signals: autocrine , paracrine , juxtacrine , and hormones . In autocrine signaling, the ligand affects the same cell that releases it. Tumor cells, for example, can reproduce uncontrollably because they release signals that initiate their own self-division. In paracrine signaling,
19552-416: The circulatory systems of animals or vascular systems of plants to reach their target cells. Once a ligand binds with a receptor, it can influence the behavior of another cell, depending on the type of receptor. For instance, neurotransmitters that bind with an inotropic receptor can alter the excitability of a target cell. Other types of receptors include protein kinase receptors (e.g., receptor for
19760-526: The domain followed by kingdom , phylum , class , order , family , genus , and species . All organisms can be classified as belonging to one of three domains : Archaea (originally Archaebacteria), bacteria (originally eubacteria), or eukarya (includes the fungi, plant, and animal kingdoms). The history of life on Earth traces how organisms have evolved from the earliest emergence of life to present day. Earth formed about 4.5 billion years ago and all life on Earth, both living and extinct, descended from
19968-479: The duplication of its DNA and some of its organelles , and the subsequent partitioning of its cytoplasm into two daughter cells in a process called cell division . In eukaryotes (i.e., animal, plant, fungal , and protist cells), there are two distinct types of cell division: mitosis and meiosis . Mitosis is part of the cell cycle, in which replicated chromosomes are separated into two new nuclei. Cell division gives rise to genetically identical cells in which
20176-402: The kingdom Plantae, which would exclude fungi and some algae . Plant cells were derived by endosymbiosis of a cyanobacterium into an early eukaryote about one billion years ago, which gave rise to chloroplasts. The first several clades that emerged following primary endosymbiosis were aquatic and most of the aquatic photosynthetic eukaryotic organisms are collectively described as algae, which
20384-403: The male's seed imposed form, the set of characteristics passed down to offspring on the "matter" ( menstrual blood ) supplied by the female. Thus female matter is the material cause of generation—it supplies the matter that will constitute the offspring—while the male semen is the efficient cause , the factor that instigates and delineates the thing's existence. Yet, Aristotle proposed in
20592-422: The microscope . It was then that scholars discovered spermatozoa , bacteria, infusoria and the diversity of microscopic life. Investigations by Jan Swammerdam led to new interest in entomology and helped to develop techniques of microscopic dissection and staining . Advances in microscopy had a profound impact on biological thinking. In the early 19th century, biologists pointed to the central importance of
20800-411: The mitochondrial cristae . Oxidative phosphorylation comprises the electron transport chain, which is a series of four protein complexes that transfer electrons from one complex to another, thereby releasing energy from NADH and FADH 2 that is coupled to the pumping of protons (hydrogen ions) across the inner mitochondrial membrane ( chemiosmosis ), which generates a proton motive force . Energy from
21008-546: The phenotype of that dominant allele. During gamete formation, the alleles for each gene segregate, so that each gamete carries only one allele for each gene. Heterozygotic individuals produce gametes with an equal frequency of two alleles. Finally, the law of independent assortment , states that genes of different traits can segregate independently during the formation of gametes, i.e., genes are unlinked. An exception to this rule would include traits that are sex-linked . Test crosses can be performed to experimentally determine
21216-496: The regulation of the rate of a metabolic reaction, for example in response to changes in the cell's environment or to signals from other cells. Cellular respiration is a set of metabolic reactions and processes that take place in cells to convert chemical energy from nutrients into adenosine triphosphate (ATP), and then release waste products. The reactions involved in respiration are catabolic reactions , which break large molecules into smaller ones, releasing energy. Respiration
21424-480: The soul , or resurrection of the body at a later date. Whether or not viruses should be considered as alive is controversial. They are most often considered as just gene coding replicators rather than forms of life. They have been described as "organisms at the edge of life" because they possess genes , evolve by natural selection, and replicate by making multiple copies of themselves through self-assembly. However, viruses do not metabolise and they require
21632-467: The structure and metabolic diversity of microbial communities in such extreme environments is ongoing. The first classification of organisms was made by the Greek philosopher Aristotle (384–322 BC), who grouped living things as either plants or animals, based mainly on their ability to move. He distinguished animals with blood from animals without blood, which can be compared with the concepts of vertebrates and invertebrates respectively, and divided
21840-412: The 3rd century, reported: Anaximander of Miletus considered that from warmed up water and earth emerged either fish or entirely fishlike animals. Inside these animals, men took form and embryos were held prisoners until puberty; only then, after these animals burst open, could men and women come out, now able to feed themselves. The Greek philosopher Anaximenes , a pupil of Anaximander, thought that air
22048-488: The Earth in air, water, and soil , with many ecosystems forming the biosphere . Some of these are harsh environments occupied only by extremophiles . Life has been studied since ancient times, with theories such as Empedocles 's materialism asserting that it was composed of four eternal elements , and Aristotle 's hylomorphism asserting that living things have souls and embody both form and matter. Life originated at least 3.5 billion years ago, resulting in
22256-490: The Needham experiment in 1768, where he attempted to exclude the possibility of introducing a contaminating factor between boiling and sealing. His technique involved boiling the broth in a sealed container with the air partially evacuated to prevent explosions. Although he did not see growth, the exclusion of air left the question of whether air was an essential factor in spontaneous generation. But attitudes were changing; by
22464-478: The Phanerozoic eon that began 539 million years ago being subdivided into Paleozoic , Mesozoic , and Cenozoic eras. These three eras together comprise eleven periods ( Cambrian , Ordovician , Silurian , Devonian , Carboniferous , Permian , Triassic , Jurassic , Cretaceous , Tertiary , and Quaternary ). The similarities among all known present-day species indicate that they have diverged through
22672-459: The Sun-like "main sequence" of stellar evolution for a shorter time interval. Small red dwarfs have the opposite problem, with a smaller habitable zone that is subject to higher levels of magnetic activity and the effects of tidal locking from close orbits. Hence, stars in the intermediate mass range such as the Sun may have a greater likelihood for Earth-like life to develop. The location of
22880-403: The abandonment of scientific interest in vitalistic theories, especially after Eduard Buchner 's demonstration that alcoholic fermentation could occur in cell-free extracts of yeast. Nonetheless, belief still exists in pseudoscientific theories such as homoeopathy , which interprets diseases and sickness as caused by disturbances in a hypothetical vital force or life force. The age of Earth
23088-689: The accumulation of favorable traits over successive generations, thereby increasing the match between the organisms and their environment. A species is a group of organisms that mate with one another and speciation is the process by which one lineage splits into two lineages as a result of having evolved independently from each other. For speciation to occur, there has to be reproductive isolation . Reproductive isolation can result from incompatibilities between genes as described by Bateson–Dobzhansky–Muller model . Reproductive isolation also tends to increase with genetic divergence . Speciation can occur when there are physical barriers that divide an ancestral species,
23296-502: The agency of the gods. The physiologoi sought the material principle or arche (Greek: ἀρχή) of things, emphasizing the rational unity of the external world and rejecting theological or mythological explanations. Anaximander , who believed that all things arose from the elemental nature of the universe, the apeiron (ἄπειρον) or the "unbounded" or "infinite", was likely the first western thinker to propose that life developed spontaneously from nonliving matter. The primal chaos of
23504-466: The appearance of new species and often the disappearance of old ones. Evolution occurs when evolutionary processes such as natural selection (including sexual selection ) and genetic drift act on genetic variation, resulting in certain characteristics increasing or decreasing in frequency within a population over successive generations. The process of evolution has given rise to biodiversity at every level of biological organisation . Fossils are
23712-450: The attributes of the lower ones. Aristotle believed that while matter can exist without form, form cannot exist without matter, and that therefore the soul cannot exist without the body. This account is consistent with teleological explanations of life , which account for phenomena in terms of purpose or goal-directedness. Thus, the whiteness of the polar bear's coat is explained by its purpose of camouflage. The direction of causality (from
23920-399: The basic functions of multicellular organisms. Signaling between cells can occur through direct cell contact using juxtacrine signalling , or indirectly through the exchange of agents as in the endocrine system . In more complex organisms, coordination of activities can occur through a dedicated nervous system . Though life is confirmed only on Earth, many think that extraterrestrial life
24128-548: The beginning, and those of animals in the aether . Another philosopher, Xenophanes , traced the origin of man back to the transitional period between the fluid stage of the Earth and the formation of land, under the influence of the Sun. In what has occasionally been seen as a prefiguration of a concept of natural selection , Empedocles accepted the spontaneous generation of life, but held that different forms, made up of differing combinations of parts, spontaneously arose as though by trial and error: successful combinations formed
24336-436: The biosphere, including soil , hot springs , inside rocks at least 19 km (12 mi) deep underground, the deepest parts of the ocean, and at least 64 km (40 mi) high in the atmosphere. For example, spores of Aspergillus niger have been detected in the mesosphere at an altitude of 48 to 77 km. Under test conditions, life forms have been observed to survive in the vacuum of space. Life forms thrive in
24544-457: The blooded animals into five groups: viviparous quadrupeds ( mammals ), oviparous quadrupeds (reptiles and amphibians ), birds, fishes and whales . The bloodless animals were divided into five groups: cephalopods , crustaceans , insects (which included the spiders, scorpions , and centipedes ), shelled animals (such as most molluscs and echinoderms ), and " zoophytes " (animals that resemble plants). This theory remained dominant for more than
24752-586: The body plan and the number, identity, and pattern of body parts. Among the most important toolkit genes are the Hox genes . Hox genes determine where repeating parts, such as the many vertebrae of snakes, will grow in a developing embryo or larva. Evolution is a central organizing concept in biology. It is the change in heritable characteristics of populations over successive generations . In artificial selection , animals were selectively bred for specific traits. Given that traits are inherited, populations contain
24960-450: The breaking down of glucose to pyruvate by cellular respiration ); or anabolic —the building up ( synthesis ) of compounds (such as proteins, carbohydrates, lipids, and nucleic acids). Usually, catabolism releases energy, and anabolism consumes energy. The chemical reactions of metabolism are organized into metabolic pathways , in which one chemical is transformed through a series of steps into another chemical, each step being facilitated by
25168-407: The cohesive force due to the attraction between molecules at the surface of the liquid. Water is also adhesive as it is able to adhere to the surface of any polar or charged non-water molecules. Water is denser as a liquid than it is as a solid (or ice). This unique property of water allows ice to float above liquid water such as ponds, lakes, and oceans, thereby insulating the liquid below from
25376-430: The cold air above. Water has the capacity to absorb energy, giving it a higher specific heat capacity than other solvents such as ethanol . Thus, a large amount of energy is needed to break the hydrogen bonds between water molecules to convert liquid water into water vapor . As a molecule, water is not completely stable as each water molecule continuously dissociates into hydrogen and hydroxyl ions before reforming into
25584-412: The conditions vary during the day and from one season to the next. To live in most ecosystems, then, organisms must be able to survive a range of conditions, called the "range of tolerance". Outside that are the "zones of physiological stress", where the survival and reproduction are possible but not optimal. Beyond these zones are the "zones of intolerance", where survival and reproduction of that organism
25792-499: The cytoplasm of a cell, there are many biomolecules such as proteins and nucleic acids . In addition to biomolecules, eukaryotic cells have specialized structures called organelles that have their own lipid bilayers or are spatially units. These organelles include the cell nucleus , which contains most of the cell's DNA, or mitochondria , which generate adenosine triphosphate (ATP) to power cellular processes. Other organelles such as endoplasmic reticulum and Golgi apparatus play
26000-453: The cytoplasm, where it is converted to waste products that may be removed from the cell. This serves the purpose of oxidizing the electron carriers so that they can perform glycolysis again and removing the excess pyruvate. Fermentation oxidizes NADH to NAD so it can be re-used in glycolysis. In the absence of oxygen, fermentation prevents the buildup of NADH in the cytoplasm and provides NAD for glycolysis. This waste product varies depending on
26208-422: The deep Mariana Trench , and inside rocks up to 580 m (1,900 ft; 0.36 mi) below the sea floor under 2,590 m (8,500 ft; 1.61 mi) of ocean off the coast of the northwestern United States, and 2,400 m (7,900 ft; 1.5 mi) beneath the seabed off Japan. In 2014, life forms were found living 800 m (2,600 ft; 0.50 mi) below the ice of Antarctica. Expeditions of
26416-622: The development of biological knowledge. He explored biological causation and the diversity of life. His successor, Theophrastus , began the scientific study of plants. Scholars of the medieval Islamic world who wrote on biology included al-Jahiz (781–869), Al-Dīnawarī (828–896), who wrote on botany, and Rhazes (865–925) who wrote on anatomy and physiology . Medicine was especially well studied by Islamic scholars working in Greek philosopher traditions, while natural history drew heavily on Aristotelian thought. Biology began to quickly develop with Anton van Leeuwenhoek 's dramatic improvement of
26624-417: The development of body form, is the result of spatial differences in gene expression. A small fraction of the genes in an organism's genome called the developmental-genetic toolkit control the development of that organism. These toolkit genes are highly conserved among phyla , meaning that they are ancient and very similar in widely separated groups of animals. Differences in deployment of toolkit genes affect
26832-437: The developmental fate of a cell, which becomes more restrictive during development. Differentiation is the process by which specialized cells arise from less specialized cells such as stem cells . Stem cells are undifferentiated or partially differentiated cells that can differentiate into various types of cells and proliferate indefinitely to produce more of the same stem cell. Cellular differentiation dramatically changes
27040-411: The discovery of archaea in almost every habitat , including soil, oceans, and marshlands . Archaea are particularly numerous in the oceans, and the archaea in plankton may be one of the most abundant groups of organisms on the planet. Archaea are a major part of Earth's life . They are part of the microbiota of all organisms. In the human microbiome , they are important in the gut , mouth, and on
27248-403: The double-helical structure of DNA by James Watson and Francis Crick in 1953, marked the transition to the era of molecular genetics . From the 1950s onwards, biology has been vastly extended in the molecular domain. The genetic code was cracked by Har Gobind Khorana , Robert W. Holley and Marshall Warren Nirenberg after DNA was understood to contain codons . The Human Genome Project
27456-631: The earliest terrestrial ecosystems , at least 2.7 billion years ago. Microorganisms are thought to have paved the way for the inception of land plants in the Ordovician period. Land plants were so successful that they are thought to have contributed to the Late Devonian extinction event . Ediacara biota appear during the Ediacaran period, while vertebrates , along with most other modern phyla originated about 525 million years ago during
27664-436: The element of the stars. This is why fire does not generate any animal ... but the heat of the sun and the heat of animals does, not only the heat that fills the seed, but also any other residue of [the animal's] nature that may exist similarly possesses this vital principle. Aristotle drew an analogy between the "foamy matter" (τὸ ἀφρῶδες, to aphrodes ) found in nature and the "seed" of an animal, which he viewed as being
27872-626: The energy and electrons to drive the synthesis of glucose by fixing atmospheric carbon dioxide into existing organic carbon compounds, such as ribulose bisphosphate (RuBP) in a sequence of light-independent (or dark) reactions called the Calvin cycle . Cell signaling (or communication) is the ability of cells to receive, process, and transmit signals with its environment and with itself. Signals can be non-chemical such as light, electrical impulses , and heat, or chemical signals (or ligands ) that interact with receptors , which can be found embedded in
28080-432: The environment. Spontaneous generation Spontaneous generation is a superseded scientific theory that held that living creatures could arise from nonliving matter and that such processes were commonplace and regular. It was hypothesized that certain forms, such as fleas , could arise from inanimate matter such as dust, or that maggots could arise from dead flesh. The doctrine of spontaneous generation
28288-523: The exception being sulfur. The latter is a component of the amino acids cysteine and methionine . The most abundant of these elements in organisms is carbon, which has the desirable attribute of forming multiple, stable covalent bonds . This allows carbon-based (organic) molecules to form the immense variety of chemical arrangements described in organic chemistry . Alternative hypothetical types of biochemistry have been proposed that eliminate one or more of these elements, swap out an element for one not on
28496-674: The experimental difficulties were far more challenging than the popular accounts suggest. The investigations of the Irish physician John Tyndall , a correspondent of Pasteur and an admirer of his work, were decisive in disproving spontaneous generation. All the same, Tyndall encountered difficulties in dealing with microbial spores , which were not well understood in his day. Like Pasteur, he boiled his cultures to sterilize them, and some types of bacterial spores can survive boiling. The autoclave , which eventually came into universal application in medical practice and microbiology to sterilise equipment,
28704-479: The expression of deleterious recessive mutations . The beneficial effect of genetic complementation, derived from outcrossing (cross-fertilization) is also referred to as hybrid vigor or heterosis. Charles Darwin in his 1878 book The Effects of Cross and Self-Fertilization in the Vegetable Kingdom at the start of chapter XII noted “The first and most important of the conclusions which may be drawn from
28912-575: The first month. Although his work predated the microscope , this led him to suggest that life came from invisible eggs. In the frontispiece of his 1651 book Exercitationes de Generatione Animalium ( Essays on the Generation of Animals ), he denied spontaneous generation with the motto omnia ex ovo ("everything from eggs"). The ancient beliefs were subjected to testing. In 1668, the Italian physician and parasitologist Francesco Redi challenged
29120-454: The form of glucose is the main nutrient used by animal and plant cells in respiration. Cellular respiration involving oxygen is called aerobic respiration, which has four stages: glycolysis , citric acid cycle (or Krebs cycle), electron transport chain , and oxidative phosphorylation . Glycolysis is a metabolic process that occurs in the cytoplasm whereby glucose is converted into two pyruvates , with two net molecules of ATP being produced at
29328-409: The formation of colonies of identical cells. These cells can form group organisms through cell adhesion . The individual members of a colony are capable of surviving on their own, whereas the members of a true multi-cellular organism have developed specialisations, making them dependent on the remainder of the organism for survival. Such organisms are formed clonally or from a single germ cell that
29536-474: The formation of Earth's major animal and plant species. This interplay between organisms and their environment is an inherent feature of living systems. The biosphere is the global sum of all ecosystems. It can also be termed as the zone of life on Earth, a closed system (apart from solar and cosmic radiation and heat from the interior of the Earth), and largely self-regulating. Organisms exist in every part of
29744-406: The fungi are more closely related to animals than to plants. As advances in microscopy enabled detailed study of cells and microorganisms, new groups of life were revealed, and the fields of cell biology and microbiology were created. These new organisms were originally described separately in protozoa as animals and protophyta/thallophyta as plants, but were united by Ernst Haeckel in
29952-480: The future to the past) is in contradiction with the scientific evidence for natural selection, which explains the consequence in terms of a prior cause. Biological features are explained not by looking at future optimal results, but by looking at the past evolutionary history of a species, which led to the natural selection of the features in question. Spontaneous generation was the belief that living organisms can form without descent from similar organisms. Typically,
30160-426: The given environment. This implies all or most of the following traits: From a physics perspective, an organism is a thermodynamic system with an organised molecular structure that can reproduce itself and evolve as survival dictates. Thermodynamically, life has been described as an open system which makes use of gradients in its surroundings to create imperfect copies of itself. Another way of putting this
30368-405: The ground, whilst others grow inside other plants ... So with animals, some spring from parent animals according to their kind, whilst others grow spontaneously and not from kindred stock; and of these instances of spontaneous generation some come from putrefying earth or vegetable matter, as is the case with a number of insects, while others are spontaneously generated in the inside of animals out of
30576-426: The hormone insulin ) and G protein-coupled receptors . Activation of G protein-coupled receptors can initiate second messenger cascades. The process by which a chemical or physical signal is transmitted through a cell as a series of molecular events is called signal transduction . The cell cycle is a series of events that take place in a cell that cause it to divide into two daughter cells. These events include
30784-442: The idea of spontaneous generation had been in decline for nearly a century, its supporters did not abandon it all at once. As James Rennie wrote in 1838, despite Redi's experiments, "distinguished naturalists, such as Blumenbach , Cuvier , Bory de St. Vincent , R. Brown , &c." continued to support the theory. Louis Pasteur 's 1859 experiment is widely seen as having settled the question of spontaneous generation. He boiled
30992-401: The idea that maggots arose spontaneously from rotting meat. In the first major experiment to challenge spontaneous generation, he placed meat in a variety of sealed, open, and partially covered containers. Realizing that the sealed containers were deprived of air, he used "fine Naples veil", and observed no worms on the meat, but they appeared on the cloth. Redi used his experiments to support
31200-434: The idea was that certain forms such as fleas could arise from inanimate matter such as dust or the supposed seasonal generation of mice and insects from mud or garbage. The theory of spontaneous generation was proposed by Aristotle , who compiled and expanded the work of prior natural philosophers and the various ancient explanations of the appearance of organisms; it was considered the best explanation for two millennia. It
31408-488: The individuals present in the observer's lifetime, whereas unsuccessful forms failed to reproduce. In his biological works , the natural philosopher Aristotle theorized extensively the reproduction of various animals, whether by sexual , parthenogenetic , or spontaneous generation. In accordance with his fundamental theory of hylomorphism , which held that every physical entity was a compound of matter and form, Aristotle's basic theory of sexual reproduction contended that
31616-496: The information to be preserved during reproduction and cell division. Within cells, DNA is organised into long structures called chromosomes . During cell division these chromosomes are duplicated in the process of DNA replication , providing each cell its own complete set of chromosomes. Eukaryotes store most of their DNA inside the cell nucleus . Cells are the basic unit of structure in every living thing, and all cells arise from pre-existing cells by division . Cell theory
31824-454: The inner mitochondrial membrane in aerobic respiration. During the third stage of photosynthesis, the movement of protons down their concentration gradients from the thylakoid lumen to the stroma through the ATP synthase is coupled to the synthesis of ATP by that same ATP synthase. The NADPH and ATPs generated by the light-dependent reactions in the second and third stages, respectively, provide
32032-459: The interaction of vital heat and elemental matter, was dependent on the proportions of pneuma and the various elements which Aristotle believed comprised all things. While Aristotle recognized that many living things emerged from putrefying matter, he pointed out that the putrefaction was not the source of life, but the byproduct of the action of the "sweet" element of water. Animals and plants come into being in earth and in liquid because there
32240-642: The kingdom Protista ; later, the prokaryotes were split off in the kingdom Monera , which would eventually be divided into two separate groups, the Bacteria and the Archaea . This led to the six-kingdom system and eventually to the current three-domain system , which is based on evolutionary relationships. However, the classification of eukaryotes, especially of protists, is still controversial. As microbiology developed, viruses, which are non-cellular, were discovered. Whether these are considered alive has been
32448-406: The last eukaryotic common ancestor. Prokaryotes (i.e., archaea and bacteria) can also undergo cell division (or binary fission ). Unlike the processes of mitosis and meiosis in eukaryotes, binary fission in prokaryotes takes place without the formation of a spindle apparatus on the cell. Before binary fission, DNA in the bacterium is tightly coiled. After it has uncoiled and duplicated, it
32656-405: The ligand diffuses to nearby cells and affects them. For example, brain cells called neurons release ligands called neurotransmitters that diffuse across a synaptic cleft to bind with a receptor on an adjacent cell such as another neuron or muscle cell . In juxtacrine signaling, there is direct contact between the signaling and responding cells. Finally, hormones are ligands that travel through
32864-563: The list, or change required chiralities or other chemical properties. Deoxyribonucleic acid or DNA is a molecule that carries most of the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses. DNA and RNA are nucleic acids ; alongside proteins and complex carbohydrates , they are one of the three major types of macromolecule that are essential for all known forms of life. Most DNA molecules consist of two biopolymer strands coiled around each other to form
33072-443: The membrane serving as membrane transporters , and peripheral proteins that loosely attach to the outer side of the cell membrane, acting as enzymes shaping the cell. Cell membranes are involved in various cellular processes such as cell adhesion , storing electrical energy , and cell signalling and serve as the attachment surface for several extracellular structures such as a cell wall , glycocalyx , and cytoskeleton . Within
33280-487: The microscope to examine foam left over from the process of brewing beer. Where the Dutch microscopist Antonie van Leeuwenhoek described "small spheroid globules", they observed yeast cells undergo cell division . Fermentation would not occur when sterile air or pure oxygen was introduced if yeast were not present. This suggested that airborne microorganisms , not spontaneous generation, was responsible. However, although
33488-508: The middle of the 19th century. It appealed to philosophers such as Henri Bergson , Friedrich Nietzsche , and Wilhelm Dilthey , anatomists like Xavier Bichat , and chemists like Justus von Liebig . Vitalism included the idea that there was a fundamental difference between organic and inorganic material, and the belief that organic material can only be derived from living things. This was disproved in 1828, when Friedrich Wöhler prepared urea from inorganic materials. This Wöhler synthesis
33696-402: The mitotic phase of an animal cell cycle—the division of the mother cell into two genetically identical daughter cells. The cell cycle is a vital process by which a single-celled fertilized egg develops into a mature organism, as well as the process by which hair, skin, blood cells , and some internal organs are renewed. After cell division, each of the daughter cells begin the interphase of
33904-436: The most abundant molecule in every organism. Water is important to life because it is an effective solvent , capable of dissolving solutes such as sodium and chloride ions or other small molecules to form an aqueous solution . Once dissolved in water, these solutes are more likely to come in contact with one another and therefore take part in chemical reactions that sustain life. In terms of its molecular structure , water
34112-597: The nature of their research questions and the tools that they use. Like other scientists, biologists use the scientific method to make observations , pose questions, generate hypotheses , perform experiments, and form conclusions about the world around them. Life on Earth, which emerged more than 3.7 billion years ago, is immensely diverse. Biologists have sought to study and classify the various forms of life, from prokaryotic organisms such as archaea and bacteria to eukaryotic organisms such as protists , fungi, plants, and animals. These various organisms contribute to
34320-448: The non-living. Legal definitions of life have been debated, though these generally focus on the decision to declare a human dead, and the legal ramifications of this decision. At least 123 definitions of life have been compiled. Since there is no consensus for a definition of life, most current definitions in biology are descriptive. Life is considered a characteristic of something that preserves, furthers or reinforces its existence in
34528-437: The observations given in this volume, is that generally cross-fertilisation is beneficial and self-fertilisation often injurious, at least with the plants on which I experimented.” Genetic variation , often produced as a byproduct of sexual reproduction, may provide long-term advantages to those sexual lineages that engage in outcrossing . Genetics is the scientific study of inheritance. Mendelian inheritance , specifically,
34736-566: The oldest from the Archaean Eon, up to 3.4 billion years old. Extinction is the process by which a species dies out. The moment of extinction is the death of the last individual of that species. Because a species' potential range may be very large, determining this moment is difficult, and is usually done retrospectively after a period of apparent absence. Species become extinct when they are no longer able to survive in changing habitat or against superior competition. Over 99% of all
34944-512: The only class of macromolecules that are not made up of polymers. They include steroids , phospholipids , and fats, largely nonpolar and hydrophobic (water-repelling) substances. Proteins are the most diverse of the macromolecules. They include enzymes , transport proteins , large signaling molecules, antibodies , and structural proteins . The basic unit (or monomer) of a protein is an amino acid . Twenty amino acids are used in proteins. Nucleic acids are polymers of nucleotides . Their function
35152-451: The operation of your sun; so is your crocodile. Antony: They are so. Shakespeare: Antony and Cleopatra : Act 2, scene 7 The author of The Compleat Angler , Izaak Walton repeats the question of the origin of eels "as rats and mice, and many other living creatures, are bred in Egypt, by the sun's heat when it shines upon the overflowing of the river...". While the ancient question of
35360-403: The organism. In skeletal muscles, the waste product is lactic acid . This type of fermentation is called lactic acid fermentation . In strenuous exercise, when energy demands exceed energy supply, the respiratory chain cannot process all of the hydrogen atoms joined by NADH. During anaerobic glycolysis, NAD regenerates when pairs of hydrogen combine with pyruvate to form lactate. Lactate formation
35568-523: The origin of eels remained unanswered and the additional idea that eels reproduced from corruption of age was mentioned, the spontaneous generation of rats and mice stirred up no debate. The Dutch biologist and microscopist Jan Swammerdam rejected the concept that one animal could arise from another or from putrification by chance because it was impious ; he found the concept of spontaneous generation irreligious, and he associated it with atheism . The Brussels physician Jan Baptist van Helmont described
35776-532: The original Greek or Arabic. They reached their greatest level of acceptance during the 13th century. With the availability of Latin translations, the German philosopher Albertus Magnus and his student Thomas Aquinas raised Aristotelianism to its greatest prominence. Albert wrote a paraphrase of Aristotle, De causis et processu universitatis , in which he removed some commentaries by Arabic scholars and incorporated others. The influential writings of Aquinas, on both
35984-432: The oxidized form of NADP, which is reduced to NADPH, a process that takes place in a protein complex called photosystem I (PSI). The transport of electrons is coupled to the movement of protons (or hydrogen) from the stroma to the thylakoid membrane, which forms a pH gradient across the membrane as hydrogen becomes more concentrated in the lumen than in the stroma. This is analogous to the proton-motive force generated across
36192-560: The parent cell divides into two or more daughter cells. For prokaryotes, cell division occurs through a process of fission in which the DNA is replicated, then the two copies are attached to parts of the cell membrane. In eukaryotes , a more complex process of mitosis is followed. However, the result is the same; the resulting cell copies are identical to each other and to the original cell (except for mutations ), and both are capable of further division following an interphase period. Multicellular organisms may have first evolved through
36400-472: The physical and metaphysical, are predominantly Aristotelian, but show numerous other influences. Spontaneous generation is described in literature as if it were a fact well into the Renaissance . Shakespeare wrote of snakes and crocodiles forming from the mud of the Nile : Lepidus : You’ve strange serpents there? Antony : Ay, Lepidus. Lepidus: Your serpent of Egypt is bred now of your mud by
36608-426: The possibility of common descent . Serious evolutionary thinking originated with the works of Jean-Baptiste Lamarck , who presented a coherent theory of evolution. The British naturalist Charles Darwin , combining the biogeographical approach of Humboldt , the uniformitarian geology of Lyell , Malthus's writings on population growth, and his own morphological expertise and extensive natural observations, forged
36816-634: The preexistence theory put forth by the Catholic Church at that time, which maintained that living things originated from parents. In scientific circles Redi's work very soon had great influence, as evidenced in a letter from the English natural theologian John Ray in 1671 to members of the Royal Society of London, in which he calls the spontaneous generation of insects "unlikely". Pier Antonio Micheli , c. 1729 , observed that when fungal spores were placed on slices of melon,
37024-473: The preserved remains or traces of organisms from the remote past. The totality of fossils, both discovered and undiscovered, and their placement in layers ( strata ) of sedimentary rock is known as the fossil record . A preserved specimen is called a fossil if it is older than the arbitrary date of 10,000 years ago. Hence, fossils range in age from the youngest at the start of the Holocene Epoch to
37232-897: The process of evolution from their common ancestor. Biologists regard the ubiquity of the genetic code as evidence of universal common descent for all bacteria , archaea , and eukaryotes . Microbial mats of coexisting bacteria and archaea were the dominant form of life in the early Archean eon and many of the major steps in early evolution are thought to have taken place in this environment. The earliest evidence of eukaryotes dates from 1.85 billion years ago, and while they may have been present earlier, their diversification accelerated when they started using oxygen in their metabolism . Later, around 1.7 billion years ago, multicellular organisms began to appear, with differentiated cells performing specialised functions. Algae-like multicellular land plants are dated back to about 1 billion years ago, although evidence suggests that microorganisms formed
37440-535: The process such as transcription , RNA splicing , translation , and post-translational modification of a protein. Gene expression can be influenced by positive or negative regulation, depending on which of the two types of regulatory proteins called transcription factors bind to the DNA sequence close to or at a promoter. A cluster of genes that share the same promoter is called an operon , found mainly in prokaryotes and some lower eukaryotes (e.g., Caenorhabditis elegans ). In positive regulation of gene expression,
37648-515: The promoter, gene expression can also be regulated by epigenetic changes to chromatin , which is a complex of DNA and protein found in eukaryotic cells. Development is the process by which a multicellular organism (plant or animal) goes through a series of changes, starting from a single cell, and taking on various forms that are characteristic of its life cycle. There are four key processes that underlie development: Determination , differentiation , morphogenesis , and growth. Determination sets
37856-406: The proton motive force drives the enzyme ATP synthase to synthesize more ATPs by phosphorylating ADPs . The transfer of electrons terminates with molecular oxygen being the final electron acceptor . If oxygen were not present, pyruvate would not be metabolized by cellular respiration but undergoes a process of fermentation . The pyruvate is not transported into the mitochondrion but remains in
38064-460: The ribosomes through an enzyme-catalyzed process called protein biosynthesis . A sequence of amino acids is assembled and joined based upon gene expression of the cell's nucleic acid. In eukaryotic cells, these proteins may then be transported and processed through the Golgi apparatus in preparation for dispatch to their destination. Cells reproduce through a process of cell division in which
38272-448: The same time. Each pyruvate is then oxidized into acetyl-CoA by the pyruvate dehydrogenase complex , which also generates NADH and carbon dioxide. Acetyl-CoA enters the citric acid cycle, which takes places inside the mitochondrial matrix. At the end of the cycle, the total yield from 1 glucose (or 2 pyruvates) is 6 NADH, 2 FADH 2 , and 2 ATP molecules. Finally, the next stage is oxidative phosphorylation, which in eukaryotes, occurs in
38480-529: The same type of fungi were produced that the spores came from, and from this observation he noted that fungi did not arise from spontaneous generation. In 1745, John Needham performed a series of experiments on boiled broths . Believing that boiling would kill all living things, he showed that when sealed right after boiling, the broths would cloud, allowing the belief in spontaneous generation to persist. His studies were rigorously scrutinized by his peers, and many of them agreed. Lazzaro Spallanzani modified
38688-476: The secretions of their several organs. According to this theory, living things may come forth from nonliving things in a manner roughly analogous to the "enformation of the female matter by the agency of the male seed" seen in sexual reproduction. Nonliving materials, like the seminal fluid present in sexual generation, contain pneuma (πνεῦμα, "breath"), or " vital heat ". According to Aristotle, pneuma had more "heat" than regular air did, and this heat endowed
38896-550: The skin. Their morphological, metabolic, and geographical diversity permits them to play multiple ecological roles: carbon fixation; nitrogen cycling; organic compound turnover; and maintaining microbial symbiotic and syntrophic communities, for example. Eukaryotes are hypothesized to have split from archaea, which was followed by their endosymbioses with bacteria (or symbiogenesis ) that gave rise to mitochondria and chloroplasts, both of which are now part of modern-day eukaryotic cells. The major lineages of eukaryotes diversified in
39104-435: The soul, like everything else, was composed of fiery atoms. He elaborated on fire because of the apparent connection between life and heat, and because fire moves. Plato , in contrast, held that the world was organised by permanent forms , reflected imperfectly in matter; forms provided direction or intelligence, explaining the regularities observed in the world. The mechanistic materialism that originated in ancient Greece
39312-493: The species that have ever lived are now extinct. Mass extinctions may have accelerated evolution by providing opportunities for new groups of organisms to diversify. The diversity of life on Earth is a result of the dynamic interplay between genetic opportunity , metabolic capability, environmental challenges, and symbiosis . For most of its existence, Earth's habitable environment has been dominated by microorganisms and subjected to their metabolism and evolution. As
39520-488: The star within a galaxy may also affect the likelihood of life forming. Stars in regions with a greater abundance of heavier elements that can form planets, in combination with a low rate of potentially habitat -damaging supernova events, are predicted to have a higher probability of hosting planets with complex life. The variables of the Drake equation are used to discuss the conditions in planetary systems where civilisation
39728-515: The start of the 19th century, a scientist such as Joseph Priestley could write that "There is nothing in modern philosophy that appears to me so extraordinary, as the revival of what has long been considered as the exploded doctrine of equivocal, or, as Dr. [Erasmus] Darwin calls it, spontaneous generation." In 1837, Charles Cagniard de la Tour , a physicist, and Theodor Schwann , one of the founders of cell theory, published their independent discovery of yeast in alcoholic fermentation . They used
39936-403: The substance with certain vital properties: The power of every soul seems to have shared in a different and more divine body than the so called [four] elements ... For every [animal], what makes the seed generative inheres in the seed and is called its "heat". But this is not fire or some such power, but instead the pneuma that is enclosed in the seed and in foamy matter, this being analogous to
40144-408: The sugar of one nucleotide and the phosphate of the next, resulting in an alternating sugar-phosphate backbone . According to base pairing rules (A with T, and C with G), hydrogen bonds bind the nitrogenous bases of the two separate polynucleotide strands to make double-stranded DNA. This has the key property that each strand contains all the information needed to recreate the other strand, enabling
40352-468: The third tenet, and by the 1860s most biologists accepted all three tenets which consolidated into cell theory . Meanwhile, taxonomy and classification became the focus of natural historians. Carl Linnaeus published a basic taxonomy for the natural world in 1735, and in the 1750s introduced scientific names for all his species. Georges-Louis Leclerc, Comte de Buffon , treated species as artificial categories and living forms as malleable—even suggesting
40560-439: The total number of chromosomes is maintained. In general, mitosis (division of the nucleus) is preceded by the S stage of interphase (during which the DNA is replicated) and is often followed by telophase and cytokinesis ; which divides the cytoplasm , organelles and cell membrane of one cell into two new cells containing roughly equal shares of these cellular components. The different stages of mitosis all together define
40768-429: The underlying genotype of an organism with a dominant phenotype. A Punnett square can be used to predict the results of a test cross. The chromosome theory of inheritance , which states that genes are found on chromosomes, was supported by Thomas Morgans 's experiments with fruit flies , which established the sex linkage between eye color and sex in these insects. A gene is a unit of heredity that corresponds to
40976-413: The universe is made up of a combination of four eternal "elements" or "roots of all": earth, water, air, and fire. All change is explained by the arrangement and rearrangement of these four elements. The various forms of life are caused by an appropriate mixture of elements. Democritus (460 BC) was an atomist ; he thought that the essential characteristic of life was having a soul ( psyche ), and that
41184-651: The waters bring forth abundantly the moving creature that hath life" ( Genesis 1:20 ) as decrees that would enable ongoing creation. From the fall of the Roman Empire in 5th century to the East–West Schism in 1054, the influence of Greek science declined, although spontaneous generation generally went unchallenged. New descriptions were made. Of the beliefs, some had doctrinal implications. In 1188, Gerald of Wales , after having traveled in Ireland, argued that
41392-449: Was applied to the generation of living things from once-living organic matter (such as boiled broths), and the English physiologist Henry Charlton Bastian proposed the term archebiosis for life originating from non-living materials. Disliking the randomness and unpredictability implied by the term spontaneous generation , in 1870 Bastian coined the term biogenesis for the formation of life from nonliving matter. Soon thereafter, however,
41600-432: Was coherently synthesized by the Greek philosopher and naturalist Aristotle , who compiled and expanded the work of earlier natural philosophers and the various ancient explanations for the appearance of organisms . Spontaneous generation was taken as scientific fact for two millennia. Though challenged in the 17th and 18th centuries by the experiments of the Italian biologists Francesco Redi and Lazzaro Spallanzani , it
41808-414: Was decisively dispelled by the experiments of Louis Pasteur in 1859, who expanded upon the investigations of predecessors such as Francesco Redi . Disproof of the traditional ideas of spontaneous generation is no longer controversial among biologists. Vitalism is the belief that there is a non-material life-principle. This originated with Georg Ernst Stahl (17th century), and remained popular until
42016-495: Was formulated by Henri Dutrochet , Theodor Schwann , Rudolf Virchow and others during the early nineteenth century, and subsequently became widely accepted. The activity of an organism depends on the total activity of its cells, with energy flow occurring within and between them. Cells contain hereditary information that is carried forward as a genetic code during cell division. There are two primary types of cells, reflecting their evolutionary origins. Prokaryote cells lack
42224-416: Was generated only from other life. Pasteur's claim followed the German physician Rudolf Virchow 's doctrine Omnis cellula e cellula ("all cells from cells"), itself derived from the work of Robert Remak . After Pasteur's 1859 experiment, the term "spontaneous generation" fell out of favor. Experimentalists used a variety of terms for the study of the origin of life from nonliving materials. Heterogenesis
42432-477: Was introduced after these experiments. In 1862, the French Academy of Sciences paid special attention to the issue, establishing a prize "to him who by well-conducted experiments throws new light on the question of the so-called spontaneous generation" and appointed a commission to judge the winner. Pasteur and others used the term biogenesis as the opposite of spontaneous generation, to mean that life
42640-431: Was launched in 1990 to map the human genome . All organisms are made up of chemical elements ; oxygen , carbon , hydrogen , and nitrogen account for most (96%) of the mass of all organisms, with calcium , phosphorus , sulfur , sodium , chlorine , and magnesium constituting essentially all the remainder. Different elements can combine to form compounds such as water, which is fundamental to life. Biochemistry
42848-453: Was not discredited until the work of the French chemist Louis Pasteur and the Irish physicist John Tyndall in the mid-19th century. Among biologists, rejecting spontaneous genesis is no longer controversial. Experiments conducted by Pasteur and others were thought to have refuted the conventional notion of spontaneous generation by the mid-1800s. Since all life appears to have evolved from
43056-433: Was revived and revised by the French philosopher René Descartes (1596–1650), who held that animals and humans were assemblages of parts that together functioned as a machine. This idea was developed further by Julien Offray de La Mettrie (1709–1750) in his book L'Homme Machine . In the 19th century the advances in cell theory in biological science encouraged this view. The evolutionary theory of Charles Darwin (1859)
43264-407: Was the element that imparted life and endowed creatures with motion and thought. He proposed that plants and animals, including human beings, arose from a primordial terrestrial slime, a mixture of earth and water, combined with the sun's heat. The philosopher Anaxagoras , too, believed that life emerged from a terrestrial slime. However, Anaximenes held that the seeds of plants existed in the air from
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